Home - Nc Folklife Institute, Nifostin

North Carolina Folklife Institute

Scenes from the 1976 Statewide Folklife Festival

Fall 2015 marks a season of exciting new beginnings for NC Folk. We’ve been around for the past 41 years, from putting on North Carolina’s first statewide folk festival in 1974, to working behind the scenes to support folklife programs of the NC Arts Council, to working statewide from our Durham offices.

But much of our work has always been “in the field”: working in cooperation with members of communities all across the state to document their traditions, helping equip them with the tools and skills to carry out projects of their own, and partnering with people, organizations, and localities in North Carolina to tap into folklife’s great potential as a tool for community development.

To maximize our resources and energies, NC Folk has moved out of our Durham office.

For many years we managed the folklife archives for the North Carolina Arts Council, to ensure that the public (especially communities documented in the archives) could have easy access to these materials. We are delighted that, through a three-way collaboration, these archives now have a great new home at the State Archives in Raleigh. Over the last two years NC Folk staff and interns have worked hard to digitize much of our contributions to the archive, so we’ll continue to have ready access to the rich products of our four decades of documentation. And of course, now our documentation is native digital, and continues to be archived and catalogued, with the goal of making as much as possible available online.

Meanwhile, our work has kept us out of the office more and more of the time. In just the past month members of our staff have been to Clinton, Cullowhee, Lexington, and Pembroke! We find that most people connect with us online — through our enormously popular monthly newsletter, on Facebook or other social media, or via our website.

For these reasons, we’ve decided to convert to a largely virtual office. We’re excited about shifting money from rent and other overhead into more robust service options, more online access to archival materials, and more online publications that share our research.

To make this ambitious plan a reality, we have also reconfigured our staff team. Evan Hatch joins our team as Director of Programs and Development. A very accomplished folklorist, Evan served for more than a decade as Director of Folk and Traditional Arts Programming for the Arts Center of Cannon County in Woodbury, Tennessee. There he designed and implemented a progressive, award-winning folk arts program that provided a national model for similar organizations. But he is a North Carolina native, and we are delighted to have helped woo him home.

Joy Salyers continues as Executive Director. You’ll find that, while NC Folk’s physical footprint has become smaller, our staff and overall organizational capacity have grown, further increasing our ability to carry out great work across the state. We’ll now primarily be working remotely and from the field, offering even more community trainings, site visits and consultations, and documentary fieldwork, as well as boosting our web and social media presence. Keep an eye out for us online and on the road! We’re thrilled about the future.

The North Carolina Folklife Institute is a 501(c)3 nonprofit organization. Donations can be made online or by check: PO Box 61222, Durham, NC 27715.

Akne-Mycin Topical Uses, Side Effects, Interactions, Pictures, Warnings - Dosing, Aknemycin

Akne-Mycin topical

Uses

This medication is used to treat acne. It helps to reduce the number of pimples. Erythromycin is an antibiotic (macrolide-type). It works by stopping the growth of bacteria. Some brands of this product contain a large amount of alcohol, which dries extra oils from the skin .

How to use Akne-Mycin topical

This medication is for use on the skin only. Clean and dry the affected area as directed. Then apply a thin layer of the medication on the skin using the applicator or cotton balls/pads, usually twice a day or as directed by your doctor. Wash your hands after use.

Do not use large amounts or apply this more often or for a longer period than directed. Your condition will not clear faster, but the risk of side effects may be increased.

Use this medication regularly in order to get the most benefit from it. Remember to use it at the same times each day.

Avoid getting this medication in your eyes or inside the nose or mouth. If this occurs, rinse thoroughly with water.

Inform your doctor if your condition does not improve or if it worsens. It may take up to 3 months of regular use before the full benefits of this medication take effect.

Side Effects

This medication may cause burning, redness, itching. or dry/peeling/oily skin, especially in the first few days as your body adjusts to the medication. Eye irritation may also occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Rarely, use of this medication may result in other types of skin infections (fungal or other bacterial infections ). Contact your doctor if you notice any unusual skin irritation or other symptoms.

A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash. itching /swelling (especially of the face/tongue /throat), severe dizziness. trouble breathing .

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before using erythromycin, tell your doctor or pharmacist if you are allergic to it; or to other antibiotics (e. g. azithromycin. clarithromycin ); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history.

This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.

It is not known if this medication passes into breast milk. Consult your doctor before breast - feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: disulfiram. metronidazole. tinidazole. other skin products (especially those that contain clindamycin or causes peeling/irritated skin).

Overdose

This medicine may be harmful if swallowed. If swallowing or overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Notes

Do not share this medication with others.

For the best results, this medication is often used as part of a total skin care program. Follow your doctor's recommendations.

Missed Dose

If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store the tightly-closed container at room temperature between 59-86 degrees F (15-30 degrees C). This medication is flammable, so keep it away from heat and open flame. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Information last revised February 2016. Copyright(c) 2016 First Databank, Inc.

Images

Enalapril (Vasotec) - Side Effects, Dosage, Interactions, Narapril

Enalapril (Vasotec)

Enalapril, sold under the brand name Vasotec, is a prescription drug used to treat high blood pressure (hypertension) and congestive heart failure .

It also treats disorders of the ventricles, the lower heart chambers that pump blood out of the heart.

Enalapril blocks a chemical that tightens blood vessels, relaxing them, resulting in a decrease in blood pressure and improvement in heart function.

It's also used to treat kidney disease related to diabetes, heart disease, and high blood pressure.

Enalapril is an ACE inhibitor (angiotensin-converting enzyme inhibitor), which prevents the constriction of blood vessels.

It also lowers the death rate in systolic heart failure, often in combination with digitalis and diuretics. The drug was developed by Merck & Co.

Enalapril Warnings

One of the side effects of enalapril is dizziness, so don’t drive if it makes you dizzy.

Enalapril can also worsen kidney problems in people who already have kidney disease.

Discuss your medical history with your doctor to determine if you are allergic to enalapril, or other ACE inhibitors. Inactive ingredients can cause allergic reactions.

Enalapril and Pregnancy

Enalapril may cause injury or death to a developing fetus, so don't use enalapril if you are pregnant.

Tell your physician immediately if you are taking enalapril and become pregnant.

Enalapril may cause several serious problems in pregnancy, some of which may result in the death of your baby.

It's also not recommended for use during breastfeeding.

Enalapril, under the brand name Vasotec, comes in tablet form in 2.5, 5, and 10 milligrams (mg).

For hypertension: the initial dose is usually 5 mg once a day. The dosage range is 10 to 40 mg per day, taken in a single dose or divided into two doses. A diuretic may be added to this as well.

For congestive heart failure: Enalapril is often taken with digitalis and diuretics, at an initial dose of 2.5 mg. Doses increase up to a maximum of 40 mg.

For left ventricular dysfunction: the initial dose is 2.5 mg twice a day, up to a maintenance dose of 20 mg.

For pediatric hypertensive patients: the initial dose is .08 mg per kg of body weight, up to not more than 0.58 mg per kg.

Enalapril can also be taken as a liquid, with or without food.

Enalapril Overdose

Call 911 or contact a poison help line at 1-800-222-1222.

Missed Dose of Enalapril

Take the dose as soon as possible, but skip it if it is nearly time for your next dose. Do not "double up" on doses.

Q: What are the long-term effects of Enalapril?

A: Enalapril is in a group of drugs called ACE inhibitors (angiotensin-converting enzyme inhibitors). Enalapril is used to treat high blood pressure (hypertension), congestive heart failure, kidney problems caused by diabetes, and to improve survival rate after heart attack. Long-term use of ACE inhibitors can improve heart and kidney function, though there can be side effects. Common side effects include dry cough, mild skin rashes, nausea, vomiting, and diarrhea. More-serious side effects can occur, including angioedema, which has symptoms including rapid swelling of the lips, eyes, face or throat, raised welts, and difficulty breathing. You may also find helpful information at http://www. everydayhealth. com/drugs/enalapril Sarah Lewis, PharmD

Q: If I am taking enalapril for more than 3 years and it is not helping me, could the doctor change it?

A: Enalapril is one of the first line medications that is used for primary hypertension or high blood pressure. I am assuming that you have used it for 3 years and it is no longer helping reduce your blood pressure. If that is the case, your physician may use several other types of medication in order to help reduce your blood pressure, or he or she may increase the dosage of the enalapril. Typically, most physicians will add on a diuretic such as Lasix (furosemide), HCTZ (hydrochlorothiazide) or Dyazide (HCTZ+Triamterine). The combination is very effective together in helping to lower the blood pressure. However, depending on your other conditions and medical history he or she may decide on a different medication entirely. Please contact your provider and have this discussion with him or her to find out what would be best for your specific needs. Matt Curley, PharmD

Q: About two weeks ago, while undergoing tests for allergies, I had an allergic reaction - swelling in my lips. I usually take enalapril and I took 20 mg doing that time. It didn't seem to work to help lower my blood pressure, which rose to 183/121. Anyhow, since then I've been careful to avoid anything with any type of nuts since the reaction was caused by almonds. However, I noticed yesterday under my lower lip a funny feeling and I eventually looked in the mirror. I saw redness and one small spot of swelling on the skin. I was baffled as to what could have caused it. I later remember it hadn't been long since I'd taken a dose of enalapril. Could this now be causing the angioedema? I never had problems like this with the enalapril and I've been taking it at least five years. I do feel I have "plateaued" on it. I've been taking the maximum dose for more than a year and it doesn't seem to have the same effects as before. Second question - I can only take ACE Inhibitors and ARBs to lower my BP because of other medical conditions, including CHF. Should I get another ACE Inhibitor? My BP is around 140/90 when I take enalapril only, and I was supposed to have a second med, but which one? I've had trouble with some of the others including clonidine, Nifedipine, Norvasc, metoprolol and propanolol, and they all had to be stopped.

A: Angioedema is an uncommon side effect with enalapril and usually occurs in the first month of treatment. Although it is possible to have this condition occur later in treatment, it is more common in African-American patients, women and people who have a history of drug or seasonal allergies. The exact prevalence and incidence of ARB-induced angioedema are not known, but are thought to be significantly lower than the ACE inhibitors. For patients who cannot take any other alternatives, ARBs seem the way to go for people who have had this issue with ACE inhibitors, although careful monitoring is recommended for the physician. There are no clear cut ways to distinguish which medication would be best in this case for your condition, but it has been shown that losartan (Cozaar) seems to show the most cases with angioedema, if it happens at all, with the ARBs. Lori Mendoza, PharmD Poulin, PharmD

Q: Would medications such as enalapril, Zetia, and Nexium cause side effects with prolonged use? I have esophageal ulcers.

A: Nexium (esomeprazole) is indicated for the treatment of GERD or gastroesophageal reflux disease. Nexium relieves heartburn that is caused by the backflow of stomach acid from the stomach to the esophagus. Nexium is also used for the treatment of ulcers. (http://www. everydayhealth. com/drugs/nexium ) Common side effects associated with Nexium include dizziness, headache, diarrhea, constipation and dry mouth. Other less common side effects associated with Nexium include muscle pain, rash, back pain and chest pain. (http://www. everydayhealth. com/gerd/understanding. aspx ). Zetia (ezetimibe) (http://www. everydayhealth. com/drugs/zetia ) is used to reduce cholesterol that the body absorbs from the diet. Zetia is indicated for high cholesterol levels along with a low fat, cholesterol diet. (http://www. everydayhealth. com/heart-disease/cholesterol/index. aspx ). Common side effects with Zetia include headache, stomach pain and diarrhea, cough, and feeling tired. A search of prescribing information showed liver abnormalities with Zetia but no concern with ulcers. Vasotec (enalapril) (http://www. everydayhealth. com/drugs/enalapril ) is an angiotensin converting enzyme drug (ACE inhibitor) that works by relaxing blood vessels. Enalapril is used for high blood pressure. http://www. everydayhealth. com/hypertension/understanding. aspx. Common side effects associated with enalapril include diarrhea, dizziness, lightheadedness when standing or sitting up, nausea, and cough. A search of prescribing information did not report enalapril causing ulcers. When your doctor prescribes a new medication, be sure to discuss all your medications and over-the-counter drugs, including dietary supplements, vitamins, botanicals, minerals and herbals, as well as the foods you eat. Also keep a current list of the drugs and supplements you take and review it with your healthcare provider and your pharmacist. If possible, use one pharmacy for all your prescription medications and over-the-counter products. This allows your pharmacist to keep a complete record of all your prescription drugs and to advise you about drug interactions and side effects. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Kimberly Hotz, PharmD

Q: About two weeks ago, while undergoing tests for allergies, I had an allergic reaction; swelling in my lips. I usually take enalapril 20 mg. It didn't seem to work to help lower my blood pressure, which rose to 183/121. Since then I've been careful to avoid anything with any type of nuts since the reaction was caused by almonds. However, yesterday, under my lower lip, I noticed a funny feeling and I eventually looked in the mirror. I saw redness and one small spot of swelling on the skin. I was baffled as to what could have caused it. I later remember it hadn't been long since I'd taken a dose of enalapril. Could this be angioedema? I have never had problems like this with enalapril and I've been taking it for at least five years. I do feel I have plateaued on it. I've been taking the maximum dose for more than a year and it doesn't seem to have the same effects as before. I can only take ACE inhibitors and ARBs to lower my blood pressure because of other medical conditions, including CHF. Should I switch to another ACE inhibitor? My blood pressure is around 140/90 when I take enalapril only, and I was supposed to have a second medication, but which one should I take? I've had trouble with some of the others including clonidine, nifedipine, Norvasc, metoprolol and propanolol, and they all had to be stopped.

A: Angioedema is an uncommon side effect associated with enalapril and usually occurs in the first month of treatment. Although it is possible to experience this condition later during treatment, it is more common in African American patients, women, and people who have a history of drug or seasonal allergies. The exact prevalence and incidence of ARB-induced angioedema are not known, but it is thought to be significantly lower than the ACE inhibitors. For patients who cannot take any other alternatives, ARBs seem to be the way to go for people who have had this issue with ACE inhibitors, although careful monitoring is recommended for the physician. There are no clear cut ways to distinguish which medication would be best in this case for your condition, but it has been shown that losartan (Cozaar) seems to show the most cases with angioedema, if it happens at all, with the ARBs. Lori Poulin, PharmD

Q: I started taking Enalapril 10 mg for my blood pressure. But I am feeling kind of dizzy and I have blurry eyes. Is this normal? What can I do?

A: Enalapril (Vasotec) is an ACE inhibitor used to treat high blood pressure and other heart conditions. Whenever starting a new blood pressure medication you may notice some dizziness especially upon standing. Be sure to stand slowly. If lying down first sit and then slowly stand when getting up. This should improve as your body gets used to having a lower blood pressure. If the dizziness is severe or does not get better, be sure to talk to your healthcare provider. Blood pressure could drop too low and a lower dose of Enalapril (Vasotec) may be necessary. Blurry eyes may be related to the dizziness, if not be sure to tell your healthcare provider. Please see the following Everyday Health link for more information on Enalapril (Vasotec). http://www. everydayhealth. com/drugs/enalapril Laura Cable, PharmD

Q: Is it better to take enalapril at night before going to bed or in the morning after breakfast?

A: Enalapril (Vasotec) can be taken at any time of day morning or night. It is important to take enalapril at the same time every day consistently. Enalapril is in a group of drugs called angiotensin converting enzyme (ACE) inhibitors. Enalapril is used to treat high blood pressure (hypertension), congestive heart failure, kidney problems caused by diabetes, and to improve survival after a heart attack. The most common side effects of enalapril are diarrhea, dizziness or lightheadedness when sitting up or standing, headache, nausea, persistent dry cough, tiredness, and vomiting. Burton Dunaway, PharmD

Q: What high blood pressure medication can I take that will not cause weight gain? I take enalapril and have gained 30 pounds. I have pre-diabetes and also take hydrochlorothiazide when needed.

A: Typically, medications used to treat high blood pressure do not cause gradual weight gain as a side effect. If weight gain is an issue, it may be due to fluid retention and should be discussed with your physician. Your physician can evaluate your health conditions and medications and make any necessary changes to your treatment regimen. Enalapril (Vasotec) is a medication in the group of drugs called angiotensin converting enzyme (ACE) inhibitors that work by causing blood vessels to relax which lowers blood pressure. According to the prescribing information for enalapril, weight gain was not a reported side effect associated with the medication. If you notice a rapid weight gain with this medication, this may be due to fluid retention and should be brought to your physician's attention. If you are noticing gradual weight gain with enalapril there are some things you can do to help. Eat a heart healthy diet containing a lot of fruits, vegetables, grains, low fat milk products. Avoid or limit the amount of saturated fats, cholesterol, salt and sugars in your diet. Regular physical activity, lasting at least 30 minutes, on most days of the week is also beneficial. Consult with your physician about any restrictions to exercise you may have. Limit your intake of alcohol. If you are experiencing weight gain as a side effect of enalapril, you should consult with your physician. For more specific information, consult with your doctor for guidance based on your health status and current medications, particularly before taking any action. Lori Poulin, PharmD

By Don Wall | Medically Reviewed by Sherry Brooks, MD

Latest Update: 2014-10-27 Copyright © 2014 Everyday Health Media, LLC

Celecoxib Medlineplus Drug Information, Cloxib

Celecoxib

People who take nonsteroidal anti-inflammatory drugs (NSAIDs) (other than aspirin) such as celecoxib may have a higher risk of having a heart attack or a stroke than people who do not take these medications. These events may happen without warning and may cause death. This risk may be higher for people who take NSAIDs for a long time. Do not take an NSAID such as celecoxib if you have recently had a heart attack, unless directed to do so by your doctor. Tell your doctor if you or anyone in your family has or has ever had heart disease, a heart attack, or a stroke, if you smoke, and if you have or have ever had high cholesterol, high blood pressure, or diabetes. Get emergency medical help right away if you experience any of the following symptoms: chest pain, shortness of breath, weakness in one part or side of the body, or slurred speech.

If you will be undergoing a coronary artery bypass graft (CABG; a type of heart surgery), you should not take celecoxib right before or right after the surgery.

NSAIDs such as celecoxib may cause ulcers, bleeding, or holes in the stomach or intestine. These problems may develop at any time during treatment, may happen without warning symptoms, and may cause death. The risk may be higher for people who take NSAIDs for a long time, are older in age, have poor health, or drink large amounts of alcohol while taking celecoxib. Tell your doctor if you drink large amounts of alcohol or if you take any of the following medications: anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); aspirin; other NSAIDs such as ibuprofen (Advil, Motrin) or naproxen (Aleve, Naprosyn); oral steroids such as dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos); selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), fluoxetine (Prozac, Sarafem, Selfemra, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft); or serotonin norepinephrine reuptake inhibitors (SNRIs) such as desvenlafaxine (Khedezla, Pristiq), duloxetine (Cymbalta), and venlafaxine (Effexor XR). Also tell your doctor if you have or have ever had ulcers or bleeding in your stomach or intestines or other bleeding disorders. If you experience any of the following symptoms, stop taking celecoxib and call your doctor: stomach pain, heartburn, vomiting a substance that is bloody or looks like coffee grounds, blood in the stool, or black and tarry stools.

Keep all appointments with your doctor and the laboratory. Your doctor will monitor your symptoms carefully and will probably order certain tests to check your body's response to celecoxib. Be sure to tell your doctor how you are feeling so that your doctor can prescribe the right amount of medication to treat your condition with the lowest risk of serious side effects.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with celecoxib and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www. fda. gov/Drugs/DrugSafety/ucm085729.htm ) or the manufacturer's website to obtain the Medication Guide.

Why is this medication prescribed?

Celecoxib is used to relieve pain, tenderness, swelling and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints), rheumatoid arthritis (arthritis caused by swelling of the lining of the joints), and ankylosing spondylitis (arthritis that mainly affects the spine). It is also used to treat juvenile rheumatoid arthritis (a type of arthritis that affects children) in children 2 years of age and older. Celecoxib is also used to treat painful menstrual periods and to relieve other types of short-term pain including pain caused by injuries, surgery and other medical or dental procedures, or medical conditions that last for a limited time. Celecoxib is in a class of NSAIDs called COX-2 inhibitors. It works by stopping the body's production of a substance that causes pain and inflammation.

How should this medicine be used?

Celecoxib comes as a capsule to take by mouth. It is usually taken once or twice a day. If you are taking up to 200 mg of celecoxib at a time, you may take the medication with or without food. If you are taking more than 200 mg of celecoxib at a time, you should take the medication with food. Ask your doctor or pharmacist if you are not sure if you need to take your medication with food. To help you remember to take celecoxib, take it around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take celecoxib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

If you cannot swallow the capsules or if you are giving this medication to a child, you may open the capsules and sprinkle the contents over a teaspoon of cold or room temperature applesauce. You may prepare the mixture in advance and store it for up to 6 hours in a refrigerator. When you are ready to take your medication, swallow all of the mixture. Then drink water to wash down the mixture and be sure that you have swallowed all of it.

Other uses for this medicine

Celecoxib is also sometimes used with surgery and other treatments to reduce the number of polyps (abnormal growths) in the colon (large intestine) and rectum in patients with familial adenomatous polyposis (a condition in which hundreds or thousands of polyps form in the colon and cancer may develop). Talk to your doctor about the risks of using this medication for your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking celecoxib,

tell your doctor and pharmacist if you are allergic to celecoxib, aspirin or other NSAIDs such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn), sulfa medications, any other medications, or any of the inactive ingredients in celecoxib capsules. Ask your pharmacist for a list of the inactive ingredients.

tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin, in Lotrel), captopril, enalapril (Vasotec, in Vaseretic), fosinopril, lisinopril (in Zestoretic), moexipril (Univasc), perindopril (Aceon, in Prestalia), quinapril (Accupril, in Quinaretic), ramipril (Altace), and trandolapril (Mavik, in Tarka); angiotensin receptor blockers such as candesartan (Atacand, in Atacand HCT), eprosartan (Teveten), irbesartan (Avapro, in Avalide), losartan (Cozaar, in Hyzaar), olmesartan (Benicar, in Azor, in Benicar HCT, in Tribenzor), telmisartan (Micardis, in Micardis HCT, in Twynsta), and valsartan (in Exforge HCT); beta blockers such as atenolol (Tenormin, in Tenoretic), labetalol (Trandate), metoprolol (Lopressor, Toprol XL, in Dutoprol), nadolol (Corgard, in Corzide), and propranolol (Hemangeol, Inderal, Innopran); diuretics ('water pills'); fluconazole (Diflucan); and lithium (Lithobid). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

tell your doctor if you have or have ever had any of the conditions mentioned in the IMPORTANT WARNING section or asthma, especially if you also have frequent stuffed or runny nose or nasal polyps (swelling of the lining of the nose); swelling of the hands, arms, feet, ankles, or lower legs; heart failure; or liver or kidney disease.

tell your doctor if you are pregnant, especially if you are in the last few months of your pregnancy, you plan to become pregnant, or you are breast-feeding. If you become pregnant while taking celecoxib, call your doctor.

if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking celecoxib.

What special dietary instructions should I follow?

Celecoxib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

diarrhea

gas or bloating

sore throat

cold symptoms

Some side effects can be serious. If you experience any of the following symptoms or those mentioned in the IMPORTANT WARNING section, call your doctor immediately. Do not take any more celecoxib until you speak to your doctor.

unexplained weight gain

shortness of breath or difficulty breathing

swelling of the abdomen, feet, ankles, or lower legs

nausea

excessive tiredness

unusual bleeding or bruising

itching

lack of energy

loss of appetite

pain in the upper right part of the stomach

yellowing of the skin or eyes

flu-like symptoms

blisters

fever

rash

hives

swelling of the face, throat, tongue, lips, eyes, or hands

hoarseness

difficulty swallowing or breathing

pale skin

fast heartbeat

cloudy, discolored, or bloody urine

back pain

difficult or painful urination

frequent urination, especially at night

Celecoxib may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www. fda. gov/Safety/MedWatch ) or by phone (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo. gl/c4Rm4p ) for more information if you do not have access to a take-back program.

In case of emergency/overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Symptoms of overdose may include:

lack of energy

drowsiness

nausea

vomiting

stomach pain

vomiting material that is bloody or looks like coffee grounds

bloody or black, tarry stools

loss of consciousness

hives

rash

swelling of the eyes, face, tongue, lips, throat, arms, hands, feet, ankles, or lower legs

difficulty breathing or swallowing

What other information should I know?

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

Your blood pressure should be checked regularly during your treatment.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand names

Fasigyn (Tinidazole) Drug, Fasigyn

Fasigyn

NOTICE: This Consumer Medicine Information (CMI) is intended for persons living in Australia. This page contains answers to some common questions about Fasigyn. It does not contain all the information that is known about Fasigyn. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risk of you using this medicine against the benefits he/she expects it will have for you. If you have any concerns about using this medicine, ask your doctor or pharmacist. Bookmark or print this page, you may need to read it again.

What Fasigyn is used for

Fasigyn is used to

treat certain infections of the male and female genital systems, liver and bowel

prevent certain infections that may occur during surgery.

Fasigyn is an antibiotic, which belongs to a group of medicines called nitroimidazoles.

Fasigyn works by killing or stopping the growth of bacteria causing your infection.

Fasigyn will not work against viral infections such as colds or flu.

Your doctor, however, may prescribe Fasigyn for another purpose.

Ask your doctor if you have any questions about why Fasigyn has been prescribed for you.

This medicine is available only with a doctor's prescription.

Before you take Fasigyn

When you must not take it

Do not take Fasigyn if you are allergic to:

any ingredients listed at the end of the leaflet

or related medicines such as Simplotan, Flagyl, Metrogyl and Metozine (not all brands given)

If you are not sure if you are allergic to any of the above, ask your doctor.

Symptoms of an allergic reaction include:

asthma, wheezing or shortness of breath

swelling of the face, lips or tongue which may lead to difficulty swallowing or breathing

hives, itching, skin rash or redness of skin

Do not take Fasigyn if you have a history of any blood disorder.

Do not take Fasigyn if you have any disease of the brain, spinal cord or nerves.

Do not take Fasigyn if you are pregnant or intend to become pregnant.

Your doctor will discuss the risks and benefits of taking Fasigyn during pregnancy (pregnancy up to four months).

If you are a woman of child-bearing age, make sure you do not become pregnant while taking Fasigyn.

Do not take Fasigyn if you are breastfeeding.

Like many other medicines, Fasigyn passes into breast milk and may harm your baby.

Do not breastfeed your baby while taking, and until at least three days after stopping Fasigyn.

If you are not sure whether you should be taking Fasigyn, talk to your doctor.

Do not take Fasigyn if the expiry date (EXP) or use by date printed on the pack has passed.

If you take this medicine after this date, it may not work.

Do not take Fasigyn if the packaging is torn or shows signs of tampering. If this is the case, return it to your pharmacist.

If you are not sure whether you should start taking Fasigyn, talk to your doctor.

Before you start to take it

You must tell your doctor if:

1. you have any allergies to:

any other medicines

any other substances, such as foods, preservatives or dyes

2. you are pregnant or intend to become pregnant

Like most other medicines, Fasigyn is not recommended in pregnancy. However, your doctor will discuss the possible risks and benefits of taking Fasigyn during pregnancy.

3. you are breastfeeding or plan to breast-feed

Like most other medicines, Fasigyn is not recommended in breast-feeding. However, your doctor will discuss the possible risks and benefits of taking Fasigyn during breast-feeding.

4. you have or have had any other medical conditions, including any kidney problems

5. you drink alcohol, even occasionally. Do not drink during and for 3 days after stopping treatment with Fasigyn.

If you drink alcohol with Fasigyn it may make you feel sick, vomit, have stomach cramps, headache or flushing.

If you have not told your doctor about any of the above, tell them before you are given Fasigyn.

Taking other medicines

Tell your doctor if you are taking any other medicines, including medicines you buy without a prescription from a pharmacy, supermarket or health food shop.

Some medicines may interfere with Fasigyn. These include:

warfarin or other medicines used to prevent blood clots

These medicines may be affected by Fasigyn or may affect how well it works.

Your doctor or pharmacist has more information on medicines to be careful with or avoid while taking Fasigyn.

Do not take medicines that contain alcohol (eg cough syrups) while using, or for three (3) days after stopping Fasigyn.

Talk to your doctor about the need for an additional method of contraception while taking Fasigyn.

Some antibiotics may decrease the effectiveness of some birth control pills, although this has not been shown with Fasigyn.

How to take Fasigyn

Follow all directions given to you by your doctor or pharmacist carefully.

They may differ from the information contained in this leaflet.

If you do not understand the instructions on the pack, ask your doctor or pharmacist for advice.

How much to take

Fasigyn is usually given as a single dose of four tablets, to be taken at the same time.

However, depending on your condition and how you react to the medicine, your doctor may ask you to take some other dose or take it for a longer time.

For children, the dose depends on body weight.

How long to take

Your doctor will tell you how long you need to keep taking Fasigyn.

In some cases, you may need to take Fasigyn for up to ten days.

How to take it

Swallow the tablets with liquid

When to take it

Take Fasigyn during or immediately after a meal.

If taken on an empty stomach, it may cause stomach upset, nausea or vomiting.

If you forget to take it

If you are taking more than a single dose of Fasigyn and if it is almost time for your next dose, skip the dose you missed and take your next dose when you are meant to.

Otherwise, take it as soon as you remember, then go back to taking it as you would normally.

Do not try to make up for missed doses by taking more than one dose at a time.

This may increase the chance of you getting an unwanted side effect.

If you are not sure what to do, check with your doctor or pharmacist.

If you have trouble remembering to take your Fasigyn, ask your pharmacist for some hints.

If you take too much (overdose)

Immediately telephone your doctor or Poisons Information Centre (telephone in Australia - 13 11 26) for advice, or go to Accident and Emergency (Casualty) at your nearest hospital if you think you or anyone else may have taken too much Fasigyn. Do this even if there are no signs of discomfort or poisoning.

You may need urgent medical attention.

Keep telephone numbers of these places handy.

If you take too many tablets, you may get an upset stomach, diarrhoea or skin rashes.

While you are taking Fasigyn

Things you must do

If you become pregnant while taking Fasigyn, tell your doctor immediately.

If you get a sore, white mouth or tongue while taking, or soon after stopping Fasigyn, tell your doctor or pharmacist.

If you get vaginal itching, burning or a white discharge while taking, or soon after stopping Fasigyn, tell your doctor or pharmacist.

This may mean you have a yeast infection called thrush. Sometimes use of Fasigyn allows yeast to grow and the above symptoms to occur. Fasigyn does not work against yeast.

If you are about to be started on any new medicines, tell your doctor or pharmacist that you are taking Fasigyn.

Tell all doctors, dentists and pharmacists who are treating you that you are taking Fasigyn.

Things you must not do

Do not give Fasigyn to anyone else, even if they have the same condition as you.

Do not use Fasigyn to treat any other medical complaints unless your doctor tells you to.

Side effects

Check with your doctor as soon as possible if you have any problems while taking Fasigyn, even if you do not think the problems are connected with the medicine or are not listed in this leaflet.

Like other medicines, Fasigyn can cause some side effects. If they occur, most are likely to be minor and temporary. However, some may be serious and need medical attention.

Ask your doctor or pharmacist to answer any questions you may have.

Tell your doctor if you notice any of the following and they worry you:

generally feeling unwell

a metallic taste in the mouth

loss of appetite, feeling sick, stomach pain, diarrhoea or constipation

Buy Fumarufen - Ketotifen - Online Without Prescriptions, Fumarufen

Zaditor (Fumarufen)

Zaditor (Ketotifen) is an antihistamine that inhibits the body's release of a chemical called histamine. Histamine can produce allergy symptoms such as sneezing, runny nose, and watery eyes. Ketotifen ophthalmic is used to treat itching of the eyes caused by allergy to dust, pollen, animals, or other allergens.

Ketotifen ophthalmic may also be used for other purposes not listed in this medication guide.

Zaditor (Ketotifen) is an antihistamine that inhibits the body's release of a chemical called histamine. Histamine can produce allergy symptoms such as sneezing, runny nose, and watery eyes. Ketotifen ophthalmic is used to treat itching of the eyes caused by allergy to dust, pollen, animals, or other allergens.

Ketotifen ophthalmic may also be used for other purposes not listed in this medication guide.

Use this medication exactly as directed on the label, or as it has been prescribed by your doctor. Do not use the medication in larger amounts, or use it for longer than recommended.

Wash your hands before using the eye drops.

If you wear contact lenses, remove them before applying ketotifen ophthalmic. This medication may contain a preservative (benzalkonium chloride) that may cause discoloration of contact lenses.

To apply the eye drops:

Tilt your head back slightly and pull down your lower eyelid. Hold the dropper above the eye with the dropper tip down. Look up and away from the dropper as you squeeze out a drop, then close your eye. Gently press your finger to the inside corner of the eye (near your nose) for about 1 minute to keep the liquid from draining into your tear duct. If you use more than one drop in the same eye, wait about 5 minutes before putting in the next drop. Do not allow the dropper tip to touch any surface, including the eyes or hands. If the dropper becomes contaminated it could cause an infection in your eye, which can lead to vision loss or serious damage to the eye.

After using the eyedrops, wait at least 10 minutes before putting contact lenses into your eyes. Do not use the eye drops if the liquid has changed colors or has particles in it. Call your doctor for a new prescription. Store the drops at room temperature away from heat and moisture. Keep the bottle tightly closed when not in use.

Use this medication exactly as directed on the label, or as it has been prescribed by your doctor.

If you miss a dose of Zaditor, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Store Zaditor at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep in a tight, light-resistant container. Keep Zaditor out of the reach of children and away from pets.

Active Ingredient: Ketotifen (0.025%) (Antihistamine)

Do not use this medication if you are allergic to ketotifen, or if you have an untreated eye infection.

Do not use it if you you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement.

Ketotifen ophthalmic should not be used to treat eye irritation caused by wearing contact lenses.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether ketotifen passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Do not use this medication in a child younger than 3 years old without the advice of a doctor.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using ketotifen ophthalmic and call your doctor at once if you have any of these serious side effects:

redness, drainage, eyelid swelling, or other signs of infection;

vision changes; or

severe itching of the eyes worse than before using the medication.

Less serious side effects may include:

mild burning, stinging, or eye irritation;

dryness of the eyes; or

increased sensitivity to light.

This is not a complete list of side effects and others may occur. Tell your doctor or health care provider about any unusual or bothersome side effect.

Zaditor is to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

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Merbentyl - Anticholinergic Agents, Antispasmodics, Antimuscarinics, Antispasmodics, Atc A03ba, Merb

Merbentyl

Merbentyl Indication

For the treatment of functional bowel/irritable bowel syndrome

Merbentyl Pharmacology

Dicyclomine is an anticholinergic drug, a medication that reduces the effect of acetylcholine, a chemical released from nerves that stimulates muscles, by blocking the receptors for acetylcholine on smooth muscle (a type of muscle). It also has a direct relaxing effect on smooth muscle. Dicyclomine is used to treat or prevent spasm in the muscles of the gastrointestinal tract in the irritable bowel syndrome. In addition, Dicyclomine inhibits gastrointestinal propulsive motility and decreases gastric acid secretion and controls excessive pharyngeal, tracheal and bronchial secretions.

Merbentyl Absorption

No information avaliable

Merbentyl side effects and Toxicity

No information avaliable

Merbentyl Patient Information

Dicyclomine may produce drowsiness or blurred vision. The patient should be warned not to engage in activities requiring mental alertness, such as operating a motor vehicle or other machinery or to perform hazardous work while taking this drug.

Dicyclomine is contraindicated in infants less than 6 months of age and in nursing mothers.

In the presence of a high environmental temperature, heat prostration can occur with drug use (fever and heat stroke due to decreased sweating).

If symptoms occur the drug should be discontinued and a physician contacted.

Merbentyl Organisms Affected

Humans and other mammals

Remote Monitoring, Avertex

Access live video from your security system when you're not there using the internet browser-based remote software or free mobile apps.

AvertX GO! mobile apps lets you stream live video from your AvertX recorder to your iPhone™, iPad™, or Android™ mobile device. Select either single camera or quad view and easily switch cameras with the swipe of your finger. Monitor your cameras remotely over 3G or anywhere you have Wi-Fi coverage. The mobile app works for a variety of security installations—you can check in on your home security system, or monitor the cameras at your business or office.

Convenient Access

The AvertX Go! app gives you anytime, anyplace access to your video surveillence system. The app features a secure login, required for each recorder, for your protection. Use the quick connect list with thumbnail images to easily connect to your recorders for live streaming video over the 3G network or Wi-Fi. To view recorded video, choose the desired time and date, or the event / alarm list gives you quick access to event video.

Internet Access

Use Internet Explorer to access your AvertX recorder remotely. View and search video from any personal computing device including Macintosh computers. You can access live video from your security system using the internet browser-based remote software or free mobile apps. Gain peace of mind knowing that your property and loved ones are safe wherever you are.

Pharmacy Express, Filginase

Description

Generic Sustiva is used to treat HIV infection in combination with other anti-HIV medications. If Generic Sustiva is the only drug you take to treat HIV infection. it may stop working.

Generic Sustiva is an oral medication that is used for the treatment of infections with the human immunodeficiency virus (HIV ). It is similar to nevirapine (Viramune) and delavirdine (Rescriptor).

Generic Sustiva is in a class of drugs called reverse transcriptase inhibitors which also includes zalcitabine (Hivid), zidovudine (Retrovir), didanosine (Videx), and lamivudine (Epivir). During infection with HIV. the HIV virus multiplies within the body's cells. The newly-formed viruses then are released from the cells and spread throughout the body where they infect other cells. In this manner, the infection continually spreads to new, uninfected cells that the body is continually producing, and HIV infection is perpetuated. When producing new viruses, the HIV virus must manufacture new DNA for each virus. Reverse transcriptase is the enzyme that the virus uses to form this new DNA. Generic Sustiva directly inhibits the activity of reverse transcriptase and blocks the production of DNA and new viruses. Unlike zidovudine, efavirenz does not need to be converted to an active form. Generic Sustiva does not kill existing HIV virus and it is not a cure for HIV .

Generic name of Generic Sustiva is Efavirenz .

Brand name of Generic Sustiva is Sustiva.

Dosage

Generic Sustiva is available in:

200mg Min Dosage

600mg Low Dosage

Take this drug by mouth, generally once daily as directed. Take on an empty stomach with a glass of water. Taking Generic Sustiva with food, especially a high-fat meal can lead to increased blood levels of the drug and increase your risk of having side effects.

Best taken at bedtime during the first month of use. Using this drug regularly at bedtime may decrease certain side effects. Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same time each day. Do not take more or less of this drug than prescribed, or stop taking it unless directed to do so by your doctor. Read the patient information leaflet provided by your pharmacist.

If you want to achieve most effective results do not stop taking Generic Sustiva suddenly.

Missing a dose

Do not take double dose. If you miss a dose you should take it as soon as you remember about your missing. If it is the time for the next dose you should continue your regular dosing schedule.

Overdose

If you overdose Generic Sustiva and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

Generic Sustiva has its side effects. The most common are:

dizziness

drowsiness or trouble sleeping may occur

mood or mental changes (depression. and in rare cases, thoughts of suicide)

dark urine

stomach pain

yellowing eyes or skin

fever

seizures

Less common but more serious side effects during taking Generic Sustiva: allergy reactions (urticaria, breathing difficulties, rash, and eruption).

Side effects manifestations are not only depend on medicine you are taking but also depend on your health state and on the other factors.

Contra-indications

Do not take Generic Sustiva if you are allergic to Generic Sustiva components.

Do not take Generic Sustiva if you are pregnant, planning to become pregnant, or are breast-feeding. It is unknown if Generic Sustiva is excreted in breast milk. Avoid breast-feeding because breast milk can transmit HIV .

Be careful with Generic Sustiva if you have mental disorders, liver disease (such as hepatitis).

Avoid machine driving.

Limit alcohol intake, as it may intensify drug side effects.

It can be dangerous to stop Generic Sustiva taking suddenly.

Frequently asked questions

Q: What is Generic Sustiva?

A: Generic Sustiva is used to treat HIV infection in combination with other anti-HIV medications. If Generic Sustiva is the only drug you take to treat HIV infection. it may stop working.

Q: How does Generic Sustiva work?

A: Generic Sustiva is an oral medication that is used for the treatment of infections with the human immunodeficiency virus (HIV ). It is similar to nevirapine (Viramune) and delavirdine (Rescriptor). Generic Sustiva is in a class of drugs called reverse transcriptase inhibitors which also includes zalcitabine (Hivid), zidovudine (Retrovir), didanosine (Videx), and lamivudine (Epivir). During infection with HIV. the HIV virus multiplies within the body's cells. The newly-formed viruses then are released from the cells and spread throughout the body where they infect other cells. In this manner, the infection continually spreads to new, uninfected cells that the body is continually producing, and HIV infection is perpetuated. When producing new viruses, the HIV virus must manufacture new DNA for each virus. Reverse transcriptase is the enzyme that the virus uses to form this new DNA. Generic Sustiva directly inhibits the activity of reverse transcriptase and blocks the production of DNA and new viruses. Unlike zidovudine, efavirenz does not need to be converted to an active form. Generic Sustiva does not kill existing HIV virus and it is not a cure for HIV .

Q: What is the generic name?

A: Generic name of Generic Sustiva is Efavirenz .

Q: What should I do in case of dose missing?

A: In case of dose missing you should take your tablet as soon as possible. Do not take double dosage. And if it is right time for the next dosage you should continue your regular schedule of Generic Sustiva taking.

Doxycin - Uses, Side Effects, Interactions, Doxyson

Doxycin

How does this medication work? What will it do for me?

Doxycycline belongs to the class of medications known as tetracyclines . It is an antibiotic that is used to treat certain infections that are caused by bacteria. It is most commonly used to treat lung infections such as pneumonia and bronchitis, urinary tract infections such as cystitis, throat infections such as tonsillitis, skin infections, and sexually transmitted infections.

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

What form(s) does this medication come in?

Each aqua capsule imprinted "H539" contains doxycycline hyclate USP equivalent to doxycycline 100 mg. Nonmedicinal ingredients: cellulose, colloidal silicon, lactose, magnesium stearate, and stearic acid. This medication does not contain alcohol, gluten, paraben, sucrose, or sulfite.

Each orange, film-coated tablet, scored on one side and embossed "DOXYCIN 100" on the other side, contains doxycycline hyclate USP equivalent to doxycycline 100 mg. Nonmedicinal ingredients: carnauba wax, cellulose, colloidal silicon, D&C Yellow, FD&C Blue, FD&C Red, FD&C Yellow, hydroxypropyl methylcellulose, magnesium stearate, polyethylene glycol, polysorbate 80, sodium starch glycolate, starch, stearic acid, and titanium dioxide. This medication does not contain alcohol, gluten, paraben, sucrose, or sulfite.

How should I use this medication?

The dose and length of treatment with doxycycline varies with the condition being treated. The usual recommended adult dose of doxycycline is 200 mg for the first dose followed by 100 mg once daily at the same time each day, with or after a meal. For some types of infections, doxycycline may be give twice daily.

The medication should be taken with plenty of water while standing or sitting upright to reduce the risk of injury to the esophagus. Do not lie down for at least 1 to 2 hours after taking the medication. This medication should not be taken with antacids or iron preparations, as these may interfere with its effectiveness.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take this medication exactly as prescribed by your doctor. Finish all of this medication, even if you start to feel better. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e. g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Who should NOT take this medication?

Do not take doxycycline if you:

are allergic to doxycycline or any ingredients of the medication

are allergic to other tetracycline antibiotics

are a woman in the second or third trimester of pregnancy

are breastfeeding

have myasthenia gravis

Do not give this medication to children under 8 years of age.

What side effects are possible with this medication?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

abdominal pain

diarrhea (mild)

flushing

loss of appetite

nausea

pain or difficulty swallowing

stomach upset

tooth discolouration

vomiting

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

headache

increased sensitivity of the skin to sunlight

ringing or buzzing noise in the ears

signs of bowel inflammation (e. g. fever that appears after starting the medication and watery and severe diarrhea, which may also be bloody)

skin rash

sore mouth or tongue

vision changes

yellowing skin or eyes

Stop taking the medication and seek immediate medical attention if any of the following occur:

signs of a severe allergic reaction (rash, itching, swelling, severe dizziness, trouble breathing)

signs of an auto-immune reaction (swelling of the hands and feet, muscle and joint pain, and rash)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Are there any other precautions or warnings for this medication?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Birth control: Some antibiotics may decrease the effectiveness of birth control pills. Ask your doctor if you should be using more than one method of birth control while you are taking this medication.

High blood pressure in the brain: Doxycycline may increase the risk of high blood pressure in the brain. Contact your doctor right away if you experience blurred vision, double vision, and headache.

Esophagus problems: People taking doxycycline have experienced ulcers and injury to their esophagus. To help prevent this, take doxycycline with a full glass of water while standing or sitting upright. Do not lie down for at least 1 to 2 hours after taking the medication.

Liver disease: People with liver disease may have a higher risk of side effects from this medication. If you have liver disease or reduced liver function, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Other infections: The use of antibiotics may occasionally result in organisms not killed by the antibiotic to overgrow, resulting in conditions such as yeast infections which may cause vaginal itching and irritation. Women may prevent yeast infections by eating yogurt daily while taking this antibiotic. Talk to your doctor if you have any concerns.

Stomach problems: People taking this medication may develop diarrhea caused by an infection with the bacteria C. difficile . Get medical attention as soon as possible if you have loose, watery, and bloody bowel movements, with or without fever or stomach cramps, after taking doxcycyline. Diarrhea caused by C. difficile infection can lead to serious health problems if it is not properly treated.

Sunburn: An exaggerated sunburn reaction may occur for some people taking tetracyclines, including doxycycline. Avoid exposure to excessive sunlight, including sunlamps and tanning beds, and use sunblock with minimum SPF 15. Stop taking doxycycline at the first sign of skin redness.

Pregnancy: Like other tetracycline antibiotics, doxycycline may cause harm to the developing baby if this medication is taken during pregnancy. This medication should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: This medication passes into breast milk and causes discoloration of the teeth and reduced bone growth in a breast-feeding infant if it is taken by the mother while still breast-feeding. Due to the adverse effects on the developing infant, this medication should not be used by women who are breast-feeding.

Children: The use of doxycycline during tooth development (from the last trimester of pregnancy to the age of 8 years) may cause permanent discoloration of the teeth (yellow-grey-brown). Though more commonly associated with long-term use of tetracyclines, this effect has also been known to occur after taking the medication for a short time.

The safety and effectiveness of using this medication have not been established for children under 8 years of age.

What other drugs could interact with this medication?

There may be an interaction between doxycycline and any of the following:

alcohol

antacids containing aluminum, calcium, or magnesium

aripiprazole

ASA (e. g. Aspirin®)

barbiturates (e. g. phenobarbital, butalbital, pentobarbital)

BCG

birth control pills

bismuth subsalicylate

calcium supplements

carbamazepine

cholestyramine

colestipol

iron and iron-containing products

magnesium supplements

methotrexate

multivitamins/minerals with vitamins A, D, and E

pancuronium

penicillins (e. g. penicillin V, amoxicillin, ampicillin)

phenytoin

pimozide

porfimer

quinapril

retinoic acid derivatives (e. g. alitretinoin, isotretinoin, tretinoin)

rifampin

rocuronium

sodium picosulfate

sucralfate

typhoid vaccine

warfarin

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

stop taking one of the medications,

change one of the medications to another,

change how you are taking one or both of the medications, or

leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Ranoxil, Ranoxil

amoxicillin

amoxicillin

an antibiotic that is a penicillin analogue similar in action to ampicillin but more efficiently absorbed from the gastrointestinal tract and therefore requiring less frequent dosage and not as likely to cause diarrhea.

a·mox·i·cil·lin

A semisynthetic penicillin antibiotic with an antimicrobial spectrum similar to that of ampicillin.

amoxicillin

/amox·i·cil·lin/ ( ah-mok″sĭ-sil?in ) a semisynthetic derivative of ampicillin effective against a broad spectrum of gram-positive and gram-negative bacteria.

amoxicillin

A semisynthetic penicillin, C 16 H 19 N 3 O 5 S, having an antibacterial spectrum of action similar to that of ampicillin.

amoxicillin

a beta-lactam semisynthetic oral penicillin antibiotic.

indication It is prescribed in the treatment of infections caused by a susceptible gram-negative or gram-positive bacteria.

contraindication Known hypersensitivity to any penicillin prohibits its use.

adverse effects Among the most serious adverse reactions are anaphylaxis, nausea, and diarrhea. Allergic reactions and rashes are common.

amoxicillin

Infectious disease A broad-spectrum semisynthetic penicillin with activity similar to that of ampicillin

amoxicillin

Amoxycillin, an AMPICILLIN - like penicillin antibiotic, effective in TYPHOID and many other infections. Brand names are Amoxil and Galenamox. Compounded with lansoprazol and clarithromycin it is marketed as Heliclear.

amoxicillin

penicillin antibiotic of similar action to ampicillin; usually administered as 250 mg by mouth every 8 hours (125 mg every 8 hours for a child) for soft-tissue infections

a·mox·i·cil·lin

A semisynthetic penicillin antibiotic with an antimicrobial spectrum similar to that of ampicillin.

amoxicillin, amoxycillin

an aminopenicillin, similar in action to ampicillin and susceptible to β-lactamase, but more efficiently absorbed from the gastrointestinal tract and with a longer duration of action.

addition of clavulanic acid widens the spectrum of activity and renders amoxicillin resistant to β-lactamase. A widely used antibiotic in dogs and cats.

Link to this page:

Ranoxil

Important Notice: The Drugs. com international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

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Artesol

It Cannoli Be Artuso's

On Monday November 3 rd. our manufacturing facility succumbed to a devastating fire. We are grateful that no one was seriously injured and all of our employees were able to get out safely. We are working fervently to ensure that we may continue to serve our customers during this time. We will continue to give regular updates as we take the necessary steps to lessen the impact on the upcoming holiday season. We ask for your patience and understanding during this transitional time as we rebuild a stronger Artuso’s. We look forward to continuing to serve our customers and we will be in communication again shortly. Please note that our retail locations in the Bronx, NY and Mamaroneck, NY were not affected by this tragedy.

The Artuso Family

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Tetracycline Dosage Guide With Precautions, Tetracyclin

Tetracycline Dosage

Usual Adult Dose for Acne

500 mg orally twice a day for 2 weeks or more, depending on the nature and severity of the infection

Usual Adult Dose for Bronchitis

500 mg orally every 6 hours for 7 to 10 days, depending on the nature and severity of the infection; may be given for 4 to 5 days a week during winter months as prophylaxis against chronic infectious bronchitis

Usual Adult Dose for Brucellosis

500 mg orally 4 times a day for 3 weeks given with streptomycin 1 g IM twice a day the first week and once a day the second week

Usual Adult Dose for Chlamydia Infection

Uncomplicated urethral, endocervical, or rectal infection: 500 mg orally 4 times a day for at least 7 days

The patient's sexual partner(s) should also be evaluated/treated.

Oral doxycycline therapy is preferred by the Centers for Disease Control and Prevention (CDC) for the treatment of chlamydial infections in nonpregnant patients.

Usual Adult Dose for Helicobacter pylori Infection

500 mg orally every 6 hours for 14 days given in conjunction with bismuth, metronidazole, and an H2 blocker

Usual Adult Dose for Lyme Disease - Arthritis

500 mg orally every 6 hours for 14 to 30 days, depending on the nature and severity of the infection

Usual Adult Dose for Lyme Disease - Carditis

500 mg orally every 6 hours for 14 to 30 days, depending on the nature and severity of the infection

Usual Adult Dose for Lyme Disease - Erythema Chronicum Migrans

500 mg orally every 6 hours for 10 to 30 days, depending on the nature and severity of the infection

Usual Adult Dose for Lyme Disease - Neurologic

500 mg orally every 6 hours for 21 to 30 days, depending on the nature and severity of the infection

Usual Adult Dose for Pneumonia

500 mg orally every 6 hours for 10 to 21 days, depending on the nature and severity of the infection

Usual Adult Dose for Rickettsial Infection

500 mg orally every 6 hours for 7 days

Usual Adult Dose for Upper Respiratory Tract Infection

500 mg orally every 6 hours for 7 to 10 days, depending on the nature and severity of the infection

Usual Adult Dose for Psittacosis

500 mg orally 4 times a day; initial treatment with IV doxycycline may be necessary for seriously ill patients Duration: Treatment should continue at least 10 to 14 days after fever subsides to prevent relapse

Usual Adult Dose for Ornithosis

500 mg orally 4 times a day; initial treatment with IV doxycycline may be necessary for seriously ill patients Duration: Treatment should continue at least 10 to 14 days after fever subsides to prevent relapse

Usual Adult Dose for Syphilis - Early

500 mg orally every 6 hours for 14 days; alternatively, 30 to 40 g in divided doses over a period of 10 to 15 days has been recommended

Tetracycline should be used only if penicillins are contraindicated.

Usual Adult Dose for Syphilis - Latent

500 mg orally every 6 hours for 28 days; alternatively, 30 to 40 g in divided doses over a period of 10 to 15 days has been recommended

Tetracycline should be used only if penicillins are contraindicated.

Usual Adult Dose for Tertiary Syphilis

500 mg orally every 6 hours for 28 days

Tetracycline should be used only if penicillins are contraindicated.

Usual Adult Dose for Nongonococcal Urethritis

500 mg orally every 6 hours for 7 days

The patient's sexual partner(s) should also be evaluated/treated.

Usual Adult Dose for Gonococcal Infection - Uncomplicated

500 mg orally 4 times a day for 7 days

The patient's sexual partner(s) should also be evaluated/treated.

Neisseria gonorrhoeae is insufficiently susceptible to tetracycline; therefore, tetracycline is not recommended by the CDC for the treatment of gonorrhea. Oral doxycycline therapy is the preferred treatment for possible concurrent chlamydial infection in nonpregnant patients.

Usual Adult Dose for Cystitis

500 mg orally every 6 hours for 3 to 7 days, depending on the nature and severity of the infection; recommended if no alternatives exist

Usual Adult Dose for Epididymitis - Sexually Transmitted

500 mg orally every 6 hours for 10 days

The patient's sexual partner(s) should also be evaluated/treated.

Doxycycline for 10 days, in conjunction with a single dose of a parenteral third-generation cephalosporin like ceftriaxone, has been specifically recommended by the CDC as primary treatment for sexually transmitted epididymitis. Tetracycline may be a reasonable substitute for doxycycline in this regimen.

Usual Adult Dose for Lymphogranuloma Venereum

Although tetracyclines in general may be useful for the treatment of lymphogranuloma venereum, doxycycline is much more commonly used and is specifically recommended by the CDC as primary therapy for this disease. Therefore, the use of tetracycline for the treatment of this patient with lymphogranuloma venereum is not recommended. Doxycycline may be an effective alternative.

Usual Adult Dose for Pelvic Inflammatory Disease

Although tetracyclines in general may be useful in combination with other agents for the treatment of pelvic inflammatory disease, doxycycline is much more commonly used and is specifically recommended by the CDC as a therapy for this disease. Therefore, the use of tetracycline for the treatment of this patient with pelvic inflammatory disease is not recommended. Doxycycline may be an effective alternative.

Usual Pediatric Dose for Bacterial Infection

Above 8 years of age: 25 to 50 mg/kg orally per day divided in 4 equal doses

Renal Dose Adjustments

Total dosage should be decreased by reduction of recommended individual doses and/or by extending time intervals between doses.

Some experts recommend : CrCl 50 to 80 mL/min: Usual dose every 8 to 12 hours CrCl 10 to 50 mL/min: Usual dose 12 to 24 hours CrCl less than 10 mL/min: Usual dose every 24 hours

Liver Dose Adjustments

Data not available

Precautions

Tetracycline may induce photosensitivity in some individuals. Patients on tetracycline therapy should minimize exposure to direct sunlight and other sources of ultraviolet radiation, and to use sunscreens and other protection whenever prolonged exposure is unavoidable. Therapy should be discontinued at the first sign of skin erythema.

If renal impairment exists, even usual oral or parenteral doses may lead to excessive systemic accumulation of the drug and possible liver toxicity. Under such conditions, lower than usual total doses are indicated and, if therapy is prolonged, serum level determinations of the drug may be advisable.

Renal, hepatic, and hematopoietic function should be monitored periodically during prolonged therapy.

Decomposed tetracyclines may cause potentially fatal nephrotoxicity (Fanconi's syndrome); therefore, outdated or decomposed medications should be discarded.

Clostridium difficile associated diarrhea (CDAD) has been reported with almost all antibiotics and may potentially be life-threatening. Therefore, it is important to consider this diagnosis in patients who present with diarrhea following tetracycline therapy. Mild cases generally improve with discontinuation of the drug, while severe cases may require supportive therapy and treatment with an antimicrobial agent effective against C difficile. Hypertoxin producing strains of C difficile cause increased morbidity and mortality; these infections can be resistant to antimicrobial treatment and may necessitate colectomy.

Dialysis

Data not available

Other Comments

Therapy should be continued for at least 1 to 2 days after symptoms and fever have subsided.

In the treatment of streptococcal infections, a therapeutic dose of tetracycline should be given for at least 10 days.

Administration of tetracycline with food, particularly dairy products, significantly reduces absorption. Tetracycline should be administered 1 hour before or 2 hours after meals. Taking the medication with a full glass of water in an upright position will help prevent esophageal ulceration and gastrointestinal irritation.

Contraindications For Cardoxin Oral, Cardoxin

contraindications

Who should not take Cardoxin?

Check with your physician if you have any of the following:

Conditions:

Restrictive Cardiomyopathy, Amyloid Heart Muscle Disease, Heart Attack, Cor Pulmonale, Constrictive Inflammation of Sac Surrounding the Heart, Idiopathic Hypertrophic Subaortic Stenosis, Atrioventricular Heart Block, Wolff-Parkinson-White Syndrome, Ventricular Fibrillation, Sick Sinus Syndrome, Sinus Bradycardia, Inflammation of the Middle Tissue Heart Muscle, Kidney Disease, Poisoning by the Heart Medication Digitalis, Serious Decrease in Thyroid Function, Low Amount of Magnesium in the Blood, High Amount of Calcium in the Blood, Low Amount of Potassium in the Blood

Allergies:

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Treatment by Condition Related to Cardoxin

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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Ergenyl Generic Name Valproic Acid Online, Ergenyl

Ergenyl General Information

Ergenyl - Pharmacology:

Ergenyl binds to and inhibits GABA transaminase. The drug's anticonvulsant activity may be related to increased brain concentrations of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the CNS, by inhibiting enzymes that catabolize GABA or block the reuptake of GABA into glia and nerve endings. Ergenyl may also work by suppressing repetitive neuronal firing through inhibition of voltage-sensitive sodium channels.

Ergenyl for patients

Since valproate products may produce CNS depression, especially when combined with another CNS depressant (eg, alcohol), patients should be advised not to engage in hazardous activities, such as driving an automobile or operating dangerous machinery, until it is known that they do not become drowsy from the drug.

This description is suitable for active ingredient Valproic Acid

Ergenyl Interactions

Effects of Co-Administered Drugs on Valproate Clearance : Drugs that affect the level of expression of hepatic enzymes, particularly those that elevate levels of glucuronosyltrans-ferases, may increase the clearance of valproate. For example, phenytoin, carbamazepine, and phenobarbital (or primidone) can double the clearance of valproate. Thus, patients on monotherapy will generally have longer half-lives and higher concentrations than patients receiving polytherapy with antiepilepsy drugs.

In contrast, drugs that are inhibitors of cytochrome P450 isozymes, e. g. antidepressants, may be expected to have little effect on valproate clearance because cytochrome P450 microsomal mediated oxidation is a relatively minor secondary metabolic pathway compared to glucuronidation and beta-oxidation.

Because of these changes in valproate clearance, monitoring of valproate and concomitant drug concentrations should be increased whenever enzyme inducing drugs are introduced or withdrawn.

The following list provides information about the potential for an influence of several commonly prescribed medications on valproate pharmacokinetics. The list is not exhaustive nor could it be, since new interactions are continuously being reported.

Drugs for which a potentially important interaction has been observed: Aspirin - A study involving the co-administration of aspirin at antipyretic doses (11 to 16 mg/kg) with valproate to pediatric patients (n=6) revealed a decrease in protein binding and an inhibition of metabolism of valproate. Valproate free fraction was increased 4-fold in the presence of aspirin compared to valproate alone. The ?-oxidation pathway consisting of 2-E-valproic acid, 3-OH-valproic acid, and 3-keto valproic acid was decreased from 25% of total metabolites excreted on valproate alone to 8. 3% in the presence of aspirin. Caution should be observed if valproate and aspirin are to be co-administered.

Felbamate - A study involving the co-administration of 1200 mg/day of felbamate with valproate to patients with epilepsy (n=10) revealed an increase in mean valproate peak concentration by 35% (from 86 to 115 µg/mL) compared to valproate alone. Increasing the felbamate dose to 2400 mg/day increased the mean valproate peak concentration to 133 µg/mL (another 16% increase). A decrease in valproate dosage may be necessary when felbamate therapy is initiated.

Rifampin - A study involving the administration of a single dose of valproate (7 mg/kg) 36 hours after 5 nights of daily dosing with rifampin (600 mg) revealed a 40% increase in the oral clearance of valproate. Valproate dosage adjustment may be necessary when it is co-administered with rifampin.

Drugs for which either no interaction or a likely clinically unimportant interaction has been observed: Antacids - A study involving the co-administration of valproate 500 mg with commonly administered antacids (Maalox, Trisogel, and Titralac - 160 mEq doses) did not reveal any effect on the extent of absorption of valproate.

Chlorpromazine - A study involving the administration of 100 to 300 mg/day of chlorpromazine to schizophrenic patients already receiving valproate (200 mg BID) revealed a 15% increase in trough plasma levels of valproate.

Haloperidol - A study involving the administration of 6 to 10 mg/day of haloperidol to schizophrenic patients already receiving valproate (200 mg BID) revealed no significant changes in valproate trough plasma levels.

Cimetidine and Ranitidine - Cimetidine and ranitidine do not affect the clearance of valproate.

Effects of Valproate on Other Drugs : Valproate has been found to be a weak inhibitor of some P450 isozymes, epoxide hydrase, and glucuronosyltransferases.

The following list provides information about the potential for an influence of valproate co-administration on the pharma-cokinetics or pharmacodynamics of several commonly prescribed medications. The list is not exhaustive, since new interactions are continuously being reported.

Drugs for which a potentially important valproate interaction has been observed: Carbamazepine/carbamazepine-10, 11-Epoxide - Serum levels of carbamazepine (CBZ) decreased 17% while that of carba-mazepine-10, 11-epoxide (CBZ-E) increased by 45% upon co-administration of valproate and CBZ to epileptic patients.

Clonazepam - The concomitant use of valproic acid and clonazepam may induce absence status in patients with a history of absence type seizures.

Diazepam - Valproate displaces diazepam from its plasma albumin binding sites and inhibits its metabolism. Co-administration of valproate (1500 mg daily) increased the free fraction of diazepam (10 mg) by 90% in healthy volunteers (n=6). Plasma clearance and volume of distribution for free diazepam were reduced by 25% and 20%, respectively, in the presence of valproate. The elimination half-life of diazepam remained unchanged upon addition of valproate.

Ethosuximide - Valproate inhibits the metabolism of ethosuximide. Administration of a single ethosuximide dose of 500 mg with valproate (800 to 1600 mg/day) to healthy volunteers (n=6) was accompanied by a 25% increase in elimination half-life of ethosuximide and a 15% decrease in its total clearance as compared to ethosuximide alone. Patients receiving valproate and ethosuximide, especially along with other anticonvulsants, should be monitored for alterations in serum concentrations of both drugs.

Lamotrigine - In a steady-state study involving 10 healthy volunteers, the elimination half-life of lamotrigine increased from 26 to 70 hours with valproate co-administration (a 165% increase). The dose of lamotrigine should be reduced when co-administered with valproate.

Phenobarbital - Valproate was found to inhibit the metabolism of phenobarbital. Co-administration of valproate (250 mg BID for 14 days) with phenobarbital to normal subjects (n=6) resulted in a 50% increase in half-life and a 30% decrease in plasma clearance of phenobarbital (60 mg single-dose). The fraction of phenobarbital dose excreted unchanged increased by 50% in presence of valproate.

There is evidence for severe CNS depression, with or without significant elevations of barbiturate or valproate serum con-centrations. All patients receiving concomitant barbiturate therapy should be closely monitored for neurological toxicity. Serum barbiturate concentrations should be obtained, if possible, and the barbiturate dosage decreased, if appropriate.

Primidone, which is metabolized to a barbiturate, may be involved in a similar interaction with valproate.

Phenytoin - Valproate displaces phenytoin from its plasma albumin binding sites and inhibits its hepatic metabolism. Co-administration of valproate (400 mg TID) with phenytoin (250 mg) in normal volunteers (n=7) was associated with a 60% increase in the free fraction of phenytoin. Total plasma clearance and apparent volume of distribution of phenytoin increased 30% in the presence of valproate. Both the clearance and apparent volume of distribution of free phenytoin were reduced by 25%.

In patients with epilepsy, there have been reports of breakthrough seizures occurring with the combination of valproate and phenytoin. The dosage of phenytoin should be adjusted as required by the clinical situation.

Tolbutamide - From in vitro experiments, the unbound fraction of tolbutamide was increased from 20% to 50% when added to plasma samples taken from patients treated with valproate. The clinical relevance of this displacement is unknown.

Warfarin - In an in vitro study, valproate increased the unbound fraction of warfarin by up to 32. 6%. The therapeutic relevance of this is unknown; however, coagulation tests should be monitored if DEPAKOTE therapy is instituted in patients taking anticoagulants.

Zidovudine - In six patients who were seropositive for HIV, the clearance of zidovudine (100 mg q8h) was decreased by 38% after administration of valproate (250 or 500 mg q8h); the half-life of zidovudine was unaffected.

Drugs for which either no interaction or a likely clinically unimportant interaction has been observed: Acetaminophen - Valproate had no effect on any of the pharmacokinetic parameters of acetaminophen when it was concurrently administered to three epileptic patients.

Amitriptyline/Nortriptyline - Administration of a single oral 50 mg dose of amitriptyline to 15 normal volunteers (10 males and 5 females) who received valproate (500 mg BID) resulted in a 21% decrease in plasma clearance of amitriptyline and a 34% decrease in the net clearance of nortriptyline.

Clozapine - In psychotic patients (n=11), no interaction was observed when valproate was co-administered with clozapine.

Lithium - Co-administration of valproate (500 mg BID) and lithium carbonate (300 mg TID) to normal male volunteers (n=16) had no effect on the steady-state kinetics of lithium.

Lorazepam - Concomitant administration of valproate (500 mg BID) and lorazepam (1 mg BID) in normal male volunteers (n=9) was accompanied by a 17% decrease in the plasma clearance of lorazepam.

Oral Contraceptive Steroids - Administration of a single-dose of ethinyloestradiol (50 µg)/levonorgestrel (250 µg) to 6 women on valproate (200 mg BID) therapy for 2 months did not reveal any pharmacokinetic interaction.

Ergenyl Contraindications

Lasix - Blood Pressure, Furosol

Furosemide is a loop diuretic causing fast and short diuresis. It possesses natriuretic effect and also decreases levels of Cl - in blood, increases excretion of K+, Ca2+, Mg2+. Penetrating into a renal tubule in ascending thick limb of Henle's loop it blocks re-absorption of Na+ and Cl-. Due to increased excretion of Na+ secondary intensified excretion of water occurs and as well as increased secretion of K+ in distal part of the renal tubule. Simultaneously excretion of Ca2+ and Mg2+ increases. Furosemide is used to treat edema syndrome in patients with chronic heart failure (degree II and III), cirrhosis, diseases of kidneys, acute heart failure (pulmonary edema), brain edema, hypertensive crisis, arterial hypertension and others.

Dosage and direction Take exactly as it was prescribed by your doctor.

Precautions Before using Furosemide, consult your doctor if you suffer from kidney disease, liver disease, gout, lupus, diabetes, or an allergy to sulfa drugs. Avoid becoming dehydrated as Furosemide makes you urinate more often. Do not stop taking the drug even if you feel fine as high blood pressure often has no symptoms. Avoid taking the drug if you are pregnant or breastfeeding.

Contraindications Hypersensitivity, acute kidney failure with anuria, severe liver failure, liver coma and precoma, stenois of urethra, acute glomerulonephritis, urinary tract obstruction, precoma, hyperglycemic coma, gout, arterial hypotension, heart attack, pancreatitis and others.

Possible side effect Contact your physician for medical attention if you have signs of allergy or any of the following conditions: dry mouth, thirst, nausea, vomiting; weakness, drowsiness, restless, or light-headed, fast or uneven heartbeat, muscle pain, less than usual urination or absence of urination, easy bruising or bleeding, red blistering skin rash, hair loss.

Drug interaction Hearing damage may occur if Furosemide is administered with aminoglycoside antibiotics (gentamicin and others) or Edecrin - another diuretic. Concomitant use of Furosemide and aspirin may cause high blood levels of aspirin and aspirin toxicity. Furosemide is able to reduce excretion of lithium by the kidneys. Sucralfate (Carafate) reduces the action of Furosemide. Intake of Ingestion of Furosemide and Sucralfate should be separated by two hours.

Missed dose The medication is sometimes administered for single use so you will not need a dosing schedule. If you take Furosemide regularly and forgot to take a dose, take it as soon as you remember. Skip the missed dose if it is almost time for the next intake. Resume your regular schedule. Do not compensate the missed dose by taking an extra one.

Overdose In case of loss of appetite, ringing in ears, severe weakness, dizziness, confusion, lightheadedness, or fainting, seek for immediate doctor's attention.

Storage Keep away from children at room temperature in a dry and dark place.

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Hipovastin Indication, Action Of Hipovastin, Interactions, Hipovastin

Hipovastin [in more detail]

Hipovastin Indication:

For management as an adjunct to diet to reduce elevated total-C, LDL-C, apo B, and TG levels in patients with primary hypercholesterolemia and mixed dyslipidemia; For primary prevention of coronary heart disease

Hipovastin Mechanism Of Action:

Hipovastin is a lactone that is readily hydrolyzed in vivo to the corresponding b-hydroxyacid, a potent inhibitor of HMG-CoA reductase, the enzyme that catalyzes the conversion of HMG-CoA to mevalonate. The conversion of HMG-CoA to mevalonate is an early step in the biosynthetic pathway for cholesterol.

Hipovastin Drug Interactions:

Amprenavir Amprenavir can possibly increase the statin toxicity Anisindione The statin increases the anticoagulant effect Acenocoumarol The statin increases the anticoagulant effect Dicumarol The statin increases the anticoagulant effect Warfarin The statin increases the anticoagulant effect Atazanavir Increased risk of myopathy/rhabdomyolysis Azithromycin Azithromycin can possibly increase the statin toxicity Bezafibrate Increased risk of myopathy/rhabdomyolysis Bosentan Bosentan could decrease the statin effect Carbamazepine Carbamazepine decreases the effect of the statin Colchicine Increased risk of rhabdomyolysis with this combination Cyclosporine Possible myopathy and rhabdomyolysis Danazol Risk of severe myopathy/rhabdomyolysis with this combination Diltiazem Diltiazem increases the effect and toxicity of the statin Fenofibrate Increased risk of myopathy/rhabdomyolysis Fluconazole Increased risk of myopathy/rhabdomyolysis Fosamprenavir Amprenavir can possibly increase the statin toxicity Gemfibrozil Increased risk of myopathy/rhabdomyolysis Imatinib Imatinib increases the effect and toxicity of statin Itraconazole Increased risk of myopathy/rhabdomyolysis Ketoconazole Increased risk of myopathy/rhabdomyolysis Nefazodone Nefazodone increases the effect and toxicity of the statin Nelfinavir Nelfinavir increases the effect and toxicity of the statin Niacin Risk of severe myopathy/rhabdomyolysis with this combination Quinupristin This combination presents an increased risk of toxicity Ritonavir Ritonavir increases the effect and toxicity of the statin Verapamil Verapamil increases the effect and toxicity of statin Telithromycin Telithromycin may possibly increase statin toxicity Tacrolimus Tacrolimus increases the effect and toxicity of the statin Clarithromycin The macrolide possibly increases the statin toxicity Erythromycin The macrolide possibly increases the statin toxicity Josamycin The macrolide possibly increases the statin toxicity Delavirdine The NNRT inhibitor increases the effect and toxicity of the statin Efavirenz The NNRT inhibitor increases the effect and toxicity of the statin Nevirapine The NNRT inhibitor increases the effect and toxicity of the statin Rifabutin The rifamycin decreases the effect of statin drug Rifampin The rifamycin decreases the effect of statin drug

Food Interactions:

Avoid drastic changes in dietary habit. Avoid alcohol. Take with food, 50% increase in bioavailability when taken with food. Avoid taking with grapefruit juice.

Hipovastin Chemical Formula:

Norvasc (Amlodipine Besylate) Side Effects, Interactions, Warning, Dosage & Uses, Amlo

NORVASC is the besylate salt of amlodipine, a long-acting calcium channel blocker .

Amlodipine besylate is chemically described as 3-Ethyl-5-methyl (±)-2-[(2-aminoethoxy)methyl]- 4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate, monobenzenesulphonate. Its empirical formula is C 20 H 25 CIN 2 O 5 •C 6 H 6 O 3 S, and its structural formula is:

Amlodipine besylate is a white crystalline powder with a molecular weight of 567.1. It is slightly soluble in water and sparingly soluble in ethanol. NORVASC (amlodipine besylate) Tablets are formulated as white tablets equivalent to 2.5, 5, and 10 mg of amlodipine for oral administration. In addition to the active ingredient, amlodipine besylate, each tablet contains the following inactive ingredients: microcrystalline cellulose, dibasic calcium phosphate anhydrous, sodium starch glycolate, and magnesium stearate.

What are the possible side effects of amlodipine (Norvasc)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

feeling like you might pass out;

swelling in your hands, ankles, or feet;

pounding heartbeats or fluttering in your chest; or

chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling.

Less serious side effects may.

What are the precautions when taking amlodipine besylate (Norvasc)?

Before taking amlodipine, tell your doctor or pharmacist if you are allergic to it; or to other dihydropyridine calcium channel blockers (such as nisoldipine, nifedipine) or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: a certain structural heart problem (aortic stenosis), very low blood pressure, liver disease.

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

Before having surgery, tell your doctor or.

Last reviewed on RxList: 1/2/2016 This monograph has been modified to include the generic and brand name in many instances.

Nox - S Realm, Eanox

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I’m aware you probably don’t care, but I posted my old customs earlier because I’m working on new ones.

I threw tattoos on the left arm because why not.

Previews (click to enlarge):

I’m pretty devoted to finishing these…so; I really won’t be posting things for a while.

And, I’m not sharing these when I’m finished, since they’re personals…so…yeah.

After doing these, however, I’m thinking about either:

1) Finishing some of the bodies on my “Currently Working On…” page

2) Starting on Halloween customs for you guys; or

3) Completing Part Two of the Hipsters 101 collection.

Summer’s almost over, though. *frustrated face*

But, hey, the teachers in my school board are planning to strike, so maybe I’ll have more time.

They were just some edits. The original body was from Lucy’s site. and the head was from; damn, I forget. But, credits to the original owner .

I’m putting these up for grabs, since I never wear them.

It’s still hard having to part with ’em.

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Inhalacion Oral De Budesonida Medlineplus Medicinas, Aerovial

Inhalacion oral de budesonida

La budesonida se utiliza para evitar la dificultad para respirar, opresion en el pecho, sibilancia y tos ocasionada por asma. El polvo de budesonida para inhalacion oral (Pulmicort Flexhaler) se usa en adultos y ninos mayores de 6 anos. La suspension de budesonida (liquido) para inhalacion oral (Pulmicort Respules) se usa en ninos de 12 meses a 8 anos de edad. La budesonida se encuentra en una clase de medicamentos llamados corticosteroides. Trabaja disminuyendo la hinchazon e irritacion en las vias respiratorias para permitir una respiracion mas facil.

?Como se debe usar este medicamento?

La budesonida viene como polvo para inhalar por la boca usando un inhalador y como una suspension para inhalar por la boca usando un nebulizador a chorro especial (maquina que convierte el medicamento en una bruma que se puede inhalar). El polvo de budesonida para inhalacion oral generalmente se inhala dos veces al dia. La suspension de budesonida para inhalacion oral generalmente se inhala una o dos veces al dia. Intente usar la budesonida aproximadamente a la misma hora todos los dias. Siga atentamente las instrucciones que se encuentran en la etiqueta de su receta medica y pida a su medico o farmaceutico que le explique cualquier parte que no comprenda. Use la budesonida exactamente como se indica. No use una cantidad mayor ni menor del medicamento, ni lo use con mas frecuencia de lo que su medico le indique.

Hable con su medico acerca de como debe usar sus otros medicamentos orales o inhalados para el asma durante su tratamiento con la inhalacion de budesonida. Si esta tomando un esteroide oral como dexametasona, metilprednisolona (Medrol) o prednisona (Rayos), es posible que su medico disminuya gradualmente su dosis de esteroide empezando despues de que haya comenzado a usar la budesonida.

La budesonida controla los sintomas del asma pero no la cura. La mejora en su asma puede ocurrir tan pronto como despues de usar el medicamento, pero los efectos totales solo se ven hasta 1 a 2 semanas despues de usar el polvo, y de 4 a 6 semanas despues de usar la suspension regularmente. Continue utilizando budesonida incluso si se siente bien. No deje de usar budesonida sin consultar a su medico. Llame a su medico si sus sintomas o los sintomas de su hijo no mejoran durante las primeras 2 semanas (polvo) o durante las primeras 6 semanas (suspension) o si empeoran.

La budesonida ayuda a evitar los ataques de asma (episodios repentinos de falta de aliento, sibilancia y tos) pero no detendra un ataque de asma que ya inicio. Su medico le recetara un inhalador de accion breve (de rescate) para que lo use durante los ataques de asma. Hable con su medico si su asma empeora durante su tratamiento.

Cada inhalador de budesonida esta disenado para proporcionar 60 o 120 inahalaciones, dependiendo de su tamano. Despues de haber usado la cantidad etiquetada de inhalaciones, es posible que las inhalaciones posteriores no contengan la cantidad correcta de medicamento. Debe dar seguimiento al numero de inhalaciones que haya usado. Puede dividir la cantidad de inhalaciones en su inhalador por el numero de inhalaciones que usa cada dia para averiguar cuantos dias durara el inhalador. Tire el inhalador despues de que haya utilizado la cantidad etiquetada de inhalaciones, incluso si todavia contiene algo de liquido y continua liberando un aerosol cuando se presiona.

No trague la suspension del nebulizador de budesonida.

Antes que use el inhalador de budesonida o nebulizador a chorro por primera vez, lea las instrucciones escritas que vienen en el empaque. Observe los diagramas atentamente y asegurese de reconocer todas las partes del inhalador o nebulizador. Pida a su medico, farmaceutico o terapeuta respiratorio que le muestre la manera correcta de usar el inhalador o nebulizador. Practique usando el inhalador o nebulizador frente a el o ella, para que este seguro de que lo hace de la manera correcta.

Para inhalar el polvo usando el inhalador, siga estos pasos:

Gire la cubierta protectora y quitela.

La primera vez que use un nuevo inhalador de budesonida debe prepararlo. Para hacer esto, sostenga el inhalador de forma vertical (con la boquilla hacia arriba), luego gire el agarrador cafe completamente a la derecha y luego regreselo a la izquierda. Escuchara un clic. Repita. La unidad esta preparada ahora y lista para cargar la primera dosis. No debe preparar el inhalador de nuevo, luego de realizar esto, incluso si no lo usa durante un periodo largo de tiempo.

Sostenga el inhalador de forma vertical, cargue la primera dosis al girar el agarrador completamente a la derecha y completamente a la izquierda hasta que haga clic.

Gire su cabeza lejos del inhalador y exhale. No sople ni exhale en el inhalador. No agite el inhalador despues de cargarlo.

Sostenga el inhalador de forma vertical (con la boquilla hacia arriba) u horizontal. Coloque la boquilla entre sus labios dentro de su boca. Incline levemente su cabeza hacia atras. Cierre sus labios apretados alrededor de la boquilla, pero no muerda ni masque la boquilla. Inhale profundamente y con fuerza. Asegurese de que la niebla entre a su garganta y no la bloqueen sus dientes o su lengua.

Retire el inhalador de su boca y contenga la respiracion aproximadamente 10 segundos. No sople ni exhale a traves del inhalador.

Si debe inhalar dos aplicaciones, repita los pasos 4 al 6. Para la siguiente aplicacion, el inhalador debe estar cargado en la posicion vertical antes que lo use. Gire el agarrador completamente a la derecha y luego completamente a la izquierda hasta que haga clic.

Vuelva a colocar la tapa de proteccion en el inhalador y cierrela.

Despues de cada tratamiento, enjuague su boca con agua y escupala. No trague el agua.

Mantenga limpio el inhalador y sequelo con la cubierta bien apretada en su lugar en todo momento.

Para inhalar la suspension con el nebulizador a chorro, siga estos pasos:

Retire una ampolla de suspension de inhalacion de la bolsa de aluminio.

Agite suavemente la ampolla con un movimiento circular.

Sostenga la ampolla de forma vertical y gire la parte superior de la ampolla. Vierta todo el liquido en el deposito del nebulizador. No mezcle otros medicamentos con budesonida en el deposito.

Conecte el deposito del nebulizador a la pieza bucal o mascarilla.

Conecte el nebulizador al compresor.

Coloque la boquilla en la boca de su hijo o use la mascarilla. Haga que su hijo se siente en una posicion erguida y comoda y encienda el compresor.

Diga a su hijo que respire de forma tranquila, profunda y uniformemente hasta que se deje de formar el vapor en la camara del nebulizador.

Despues de cada tratamiento, haga que su hijo se enjuague la boca con agua y que la escupa; no debe tragar el agua.

Deseche la ampolla vacia y su parte superior en un basurero que este fuera del alcance de los ninos y las mascotas.

Limpie el nebulizador regularmente. Siga atentamente las instrucciones del fabricante y pregunte a su medico o farmaceutico si tiene alguna duda sobre la limpieza del nebulizador.

?Que otro uso se le da a este medicamento?

Este medicamento algunas veces se receta para otros usos; pida mas informacion a su medico o farmaceutico.

?Cuales son las precauciones especiales que debo seguir?

Antes que use la inhalacion de budesonida,

informe a su medico y farmaceutico si es alergico a la budesonida, a cualquier otro medicamento o a alguno de los ingredientes en el polvo de inhalacion de budesonida o la solucion del nebulizador. Si usara el polvo para inhalacion, indique tambien a su medico si es alergico a las proteinas de la leche. Preguntele a su farmaceutico o revise la Guia del medicamento para obtener la lista de ingredientes.

informe a su medico y farmaceutico que medicamentos con y sin receta medica, vitaminas, suplementos nutricionales y productos de hierbas esta tomando o ha tomado recientemente. Asegurese de mencionar cualquiera de los siguientes: ciertos antimicoticos como itroconazol (Onmel, Sporanox) y ketoconazol (Nizoral); claritromicina (Biaxin); inhibidores de la proteasa del VIH como atazanavir (Reyataz, en Evotaz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir en Kaletra, en Viekira Pak, otros) y saquinavir (Invirase); medicamentos para las convulsiones, nefazodona; esteroides orales como dexametasona, metilprednisolona (Medrol) y prednisona (Rayos); y telitromicina (Ketek). Es posible que su medico deba cambiar las dosis de sus medicamentos o supervisarle atentamente para saber si sufre efectos secundarios. Muchos otros medicamentos tambien podrian interactuar con la inhalacion de budesonida, asi que asegurese de informar a su medico sobre todos los medicamentos que esta tomando, incluso los que no aparecen en esta lista.

no utilice la budesonida durante un ataque de asma. Su medico le recetara un inhalador de accion breve (de rescate) para que lo use durante los ataques de asma. Llame a su medico si tiene un ataque de asma que no se detiene cuando usa su medicamento de asma de rapida accion o si necesita usar mas de lo usual de su medicamento de rapida accion.

indique a su medico si usted o alguien en su familia tiene o ha tenido osteoporosis (una afeccion en la cual los huesos se adelgazan y se debilitan y quiebran facilmente) y si usted tiene o ha tenido tuberculosis (TB; un tipo de infeccion pulmonar grave) en sus pulmones, cataratas (lente del ojo nublado), glaucoma (una enfermedad de los ojos) o alta presion en el ojo o enfermedad hepatica. Indique tambien a su medico si tiene algun tipo de infeccion sin tratar en cualquier lugar de su cuerpo o una infeccion por herpes en el ojo (un tipo de infeccion que causa un dolor en el parpado o la superficie del ojo).

informe a su medico si esta embarazada, tiene planificado embarazarse o esta amamantando. Llame a su medico si queda embarazada mientras usa budesonida.

si se sometera a una cirugia, incluso cirugia dental, informe a su medico o dentista que usa budesonida.

si tiene cualquier otra afeccion medica, como asma, artritis o eczema (una enfermedad de la piel), que pueda empeorar al disminuir su dosis de esteroide oral. Indique a su medico si esto sucede o si experimenta cualquiera de los siguientes sintomas durante este tiempo: cansancio extremo, debilidad muscular o dolor; dolor de estomago repentino, dolor en la parte inferior del cuerpo o en las piernas, perdida del apetito; perdida de peso; malestar estomacal; vomitos; diarrea; mareos; desmayos; depresion; irritabilidad y oscurecimiento de la piel. Su cuerpo podria tener menos capacidad para tratar con el estres de una cirugia, enfermedad, ataque grave de asma o lesion durante este tiempo. Llame a su medico inmediatamente si se siente enfermo y asegurese de que todos los proveedores de atencion medica que lo tratan saben que reemplazaron recientemente su esteroide oral con inhalacion de budesonida. Lleve una tarjeta o use un brazalete de identificacion medica para que el personal de emergencia sepa que necesita ser tratado con esteroides en una emergencia.

informe a su medico si nunca ha tenido varicela o paperas y no ha sido vacunado contra estas infecciones. Mantengase lejos de las personas que estan enfermas, especialmente personas que tienen varicela o paperas. Si esta expuesto a una de estas infecciones o si desarrolla sintomas de estas infecciones, llame a su medico de inmediato. Es posible que reciba tratamiento para protegerle de estas infecciones.

debe saber que la inhalacion de budesonida algunas veces causa sibilancia y dificultad para respirar inmediatamente despues de inhalarla. Si esto sucede, utilice su medicamento de asma de rapida accion (de rescate) de inmediato y llame a su medico. No use de nuevo la inhalacion de budesonida a menos que su medico se lo indique.

?Que dieta especial debo seguir mientras tomo este medicamento?

A menos que su medico le indique lo contrario, continue con su dieta normal.

?Que tengo que hacer si me olvido de tomar una dosis?

Omita la dosis que le falto y continue con su programa regular de dosificacion. No duplique la dosis para compensar la dosis omitida.

?Cuales son los efectos secundarios que podria provocar este medicamento?

La inhalacion de budesonida puede ocasionar efectos secundarios. Informe a su medico si cualquiera de estos sintomas es intenso o no desaparece:

dolor de cabeza

nariz congestionada o secrecion nasal

dolor de garganta

diarrea

perdida de apetito

dolor de estomago

dificultad para conciliar el sueno o para mantenerse dormido

dolor de cuello o de espalda

infeccion del oido

sangrado de nariz

Algunos efectos secundarios pueden ser graves. Si experimenta cualquiera de los siguientes sintomas o cualquiera en la seccion PRECAUCIONES ESPECIALES, llame a su medico inmediatamente u obtenga tratamiento medico de emergencia:

puntos blancos o llagas en la boca

sarpullido

urticaria

picazon

inflamacion del rostro, garganta, lengua, labios, ojos, manos, pies, tobillos o parte inferior de las piernas

ronquera

dificultad para respirar o tragar

jadeo

tos

dolor de pecho

ansiedad

fiebre, escalofrios u otros sintomas de infeccion

cansancio

nausea

vomitos

debilidad

cambios en la vision

La inhalacion de budesonida puede ocasionar que los ninos crezcan mas despacio. No hay suficiente informacion para indicar si el uso de budesonida disminuye la altura final a la que llegaran los ninos cuando se detiene su crecimiento. El medico de su hijo observara atentamente el crecimiento de su hijo mientras que usa budesonida. Hable con el medico de su hijo sobre los riesgos de administrar este medicamento a su hijo.

En casos excepcionales, las personas que usan budesonida durante un largo tiempo desarrollaron glaucoma o cataratas. Hable con su medico sobre los riesgos del uso de budesonida y con que frecuencia debe examinar sus ojos durante el tratamiento.

La budesonida puede aumentar su riesgo de desarrollar osteoporosis (una afeccion en la que los huesos se debilitan y adelgazan y se rompen facilmente). Hable con su medico sobre los riesgos de usar este medicamento.

La inhalacion de budesonida puede ocasionar otros efectos secundarios. Llame a su medico si tiene algun problema inusual mientras usa este medicamento.

Si desarrolla un efecto secundario grave, usted o su doctor puede enviar un informe al programa de divulgacion de efectos adversos 'MedWatch' de la Administracion de Alimentos y Medicamentos (FDA, por su sigla en ingles) en la pagina de Internet (http://www. fda. gov/Safety/MedWatch ) o por telefono al 1-800-332-1088.

?Como debo almacenar o desechar este medicamento?

Mantenga este medicamento en su envase original, cerrado hermeticamente y fuera del alcance de los ninos. Mantenga las ampollas del nebulizador selladas en sus bolsas de aluminio hasta que este listo para usarlas. Almacene el inhalador y la solucion del nebulizador a temperatura ambiente y lejos del exceso de calor y humedad (no en el bano). No refrigere ni congele la solucion del nebulizador. Si usa el polvo para inhalacion, reemplace su inhalador anterior cada vez que vuelva a surtir su receta medica. Si usa la solucion del nebulizador, debe desechar las ampollas si no las utilizo 2 semanas despues de abrir la bolsa de aluminio.

Los medicamentos que ya no son necesarios se deben desechar de una manera apropiada para asegurarse de que las mascotas, los ninos y otras personas no puedan consumirlos. Sin embargo, no debe desechar estos medicamentos por el inodoro. En su lugar, la mejor manera de deshacerse de sus medicamentos es a traves de un programa de devolucion de medicamentos. Hable con su farmaceutico o pongase en contacto con su departamento de basura/reciclaje local para conocer acerca de los programas de devolucion de medicamentos de su comunidad. Consulte el sitio web de la Administracion de Medicamentos y Alimentos (FDA), (http://goo. gl/c4Rm4p ) para obtener mas informacion de como desechar de forma segura los medicamentos, si no tiene acceso al programa de devolucion de medicamentos.

?Que otra informacion de importancia deberia saber?

Asista a todas las citas con su medico y el laboratorio.

No deje que nadie mas use su medicamento. Haga a su farmaceutico cualquier pregunta que tenga sobre como volver a surtir su receta medica.

Es importante que Ud. mantenga una lista escrita de todas las medicinas que Ud. esta tomando, incluyendo las que recibio con receta medica y las que Ud. compro sin receta, incluyendo vitaminas y suplementos de dieta. Ud. debe tener la lista cada vez que visita su medico o cuando es admitido a un hospital. Tambien es una informacion importante en casos de emergencia.

Marcas comerciales

Ciprofloxacin - Cipro ® - Intravenous (Iv) Dilution, Cipro-Q

Ciprofloxacin - Cipro ®

The authors make no claims of the accuracy of the information contained herein; and these suggested doses and/or guidelines are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this document shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material. PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.

Usual Diluents

Standard Dilutions [Amount of drug] [Infusion volume] [Infusion rate]

If 'Ready-to-Use' prep not available: [200 mg] [100 ml] [1 hour] [400 mg] [250 ml] [1 hour]

Primary : -------Ready to Use------------ Ciprofloxacin in 5% dextrose injection, USP is available in 200 mg and 400 mg strengths. The 2 mg/mL infusion solution is supplied in latex-free flexible containers as follows:

*DUE TO THE DESIGNATED PATHOGENS ^ used in conjunction with metronidazole. (See product labeling for prescribing information.)

^^ Drug administration should begin as soon as possible after suspected or confirmed exposure. This indication is based on a surrogate endpoint, ciprofloxacin serum concentrations achieved in humans, reasonably likely to predict clinical benefit.4 For a discussion of ciprofloxacin serum concentrations in various human populations, see INHALATIONAL ANTHRAX — ADDITIONAL INFORMATION. Total duration of ciprofloxacin administration (IV or oral) for inhalational anthrax (post-exposure) is 60 days.

Ciprofloxacin injection should be administered by intravenous infusion over a period of 60 minutes.

Conversion of IV to Oral Dosing in Adults . Ciprofloxacin tablets and oral suspension for oral administration are available. Parenteral therapy may be switched to oral ciprofloxacin when the condition warrants, at the discretion of the physician.

Equivalent AUC Dosing Regimens

Ciprofloxacin Oral Dosage

Equivalent Ciprofloxacin Injection Dosage

250 mg Tablet q 12 h

200 mg IV q 12 h

500 mg Tablet q 12 h

400 mg IV q 12 h

750 mg Tablet q 12 h

Adults with Impaired Renal Function . Ciprofloxacin is eliminated primarily by renal excretion; however, the drug is also metabolized and partially cleared through the biliary system of the liver and through the intestine. These alternative pathways of drug elimination appear to compensate for the reduced renal excretion in patients with renal impairment. Nonetheless, some modification of dosage is recommended for patients with severe renal dysfunction. The following table provides dosage guidelines for use in patients with renal impairment:

RECOMMENDED STARTING AND MAINTENANCE DOSES

FOR PATIENTS WITH IMPAIRED RENAL FUNCTION

Creatinine Clearance (mL/min)

See usual dosage

200-400 mg q 18-24 hr

When only the serum creatinine concentration is known, the following formula may be used to estimate creatinine clearance:

Men: Creatinine clearance (mL/min) = Weight (kg) x (140 – age) / [72 x serum creatinine (mg/dL)]

Women: 0.85 x the value calculated for men.

The serum creatinine should represent a steady state of renal function.

For patients with changing renal function or for patients with renal impairment and hepatic insufficiency, careful monitoring is suggested.

DOSAGE AND ADMINISTRATION – PEDIATRICS Ciprofloxacin injection should be administered by intravenous infusion as described in the Dosage Guidelines table.

An increased incidence of adverse events compared to controls, including events related to joints and/or surrounding tissues, has been observed. (See package insert for ADVERSE REACTIONS and CLINICAL STUDIES.)

Dosing and initial route of therapy (i. e. IV or oral) for complicated urinary tract infection or pyelonephritis should be determined by the severity of the infection. In the clinical trial, pediatric patients with moderate to severe infection were initiated on 6 to 10 mg/kg IV every 8 hours and allowed to switch to oral therapy (10 to 20 mg/kg every 12 hours), at the discretion of the physician.

PEDIATRIC DOSAGE GUIDELINES

* The total duration of therapy for complicated urinary tract infection and pyelonephritis in the clinical trial was determined by the physician. The mean duration of treatment was 11 days (range 10 to 21 days).

** Drug administration should begin as soon as possible after suspected or confirmed exposure to Bacillus anthracis spores. This indication is based on a surrogate endpoint, ciprofloxacin serum concentrations achieved in humans, reasonably likely to predict clinical benefit.4 For a discussion of ciprofloxacin serum concentrations in various human populations, see INHALATIONAL ANTHRAX — ADDITIONAL INFORMATION.

Preparation of Ciprofloxacin Injection for Administration Vials (Injection Concentrate): THIS PREPARATION MUST BE DILUTED BEFORE USE. The intravenous dose should be prepared by aseptically withdrawing the concentrate from the vial of ciprofloxacin injection. This should be diluted with a suitable intravenous solution to a final concentration of 1 to 2 mg/mL. (See COMPATIBILITY AND STABILITY.) The resulting solution should be infused over a period of 60 minutes by direct infusion or through a Y-type intravenous infusion set which may already be in place.

If the Y-type or “piggyback” method of administration is used, it is advisable to discontinue temporarily the administration of any other solutions during the infusion of ciprofloxacin injection. If the concomitant use of ciprofloxacin injection and another drug is necessary each drug should be given separately in accordance with the recommended dosage and route of administration for each drug.

COMPATIBILITY AND STABILITY Ciprofloxacin injection 1% (10 mg/mL), when diluted with the following intravenous solutions to concentrations of 0.5 to 2 mg/mL, is stable for up to 14 days at refrigerated or room temperature storage.

0.9% Sodium Chloride Injection 5% Dextrose Injection Sterile Water for Injection 10% Dextrose for Injection 5% Dextrose and 0.225% Sodium Chloride for Injection 5% Dextrose and 0.45% Sodium Chloride for Injection Lactated Ringer’s for Injection

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

HOW SUPPLIED Ciprofloxacin Injection USP is available as a clear, colorless to slightly yellowish solution. Ciprofloxacin Injection is available in 200 mg and 400 mg strengths. The concentrate is supplied in vials as follows:

NDC 55390-197-01 – 200 mg, 1%, 20 mL Vial; individually boxed NDC 55390-198-01 – 400 mg, 1%, 40 mL Vial; individually boxed

STORAGE Store between 5° to 30°C (41° to 86°F). Protect from light, avoid excessive heat, protect from freezing.

INHALATIONAL ANTHRAX — ADDITIONAL INFORMATION

The mean serum concentrations of ciprofloxacin associated with a statistically significant improvement in survival in the rhesus monkey model of inhalational anthrax are reached or exceeded in adult and pediatric patients receiving oral and intravenous regimens. (See DOSAGE AND ADMINISTRATION .) Ciprofloxacin pharmacokinetics have been evaluated in various human populations. The mean peak serum concentration achieved at steady-state in human adults receiving 500 mg orally every 12 hours is 2.97 mcg/mL, and 4.56 mcg/mL following 400 mg intravenously every 12 hours. The mean trough serum concentration at steady-state for both of these regimens is 0.2 mcg/mL. In a study of 10 pediatric patients between 6 and 16 years of age, the mean peak plasma concentration achieved is 8.3 mcg/mL and trough concentrations range from 0.09 to 0.26 mcg/mL, following two 30-minute intravenous infusions of 10 mg/kg administered 12 hours apart. After the second intravenous infusion patients switched to 15 mg/kg orally every 12 hours achieve a mean peak concentration of 3.6 mcg/mL after the initial oral dose. Long-term safety data, including effects on cartilage, following the administration of ciprofloxacin to pediatric patients are limited. (For additional information, see PRECAUTIONS: Pediatric Use.) Ciprofloxacin serum concentrations achieved in humans serve as a surrogate endpoint reasonably likely to predict clinical benefit and provide the basis for this indication.4

A placebo-controlled animal study in rhesus monkeys exposed to an inhaled mean dose of 11 LD50 (

5.5 x 105) spores (range 5 to 30 LD50) of B. anthracis was conducted. The minimal inhibitory concentration (MIC) of ciprofloxacin for the anthrax strain used in this study was 0.08 mcg/mL. In the animals studied, mean serum concentrations of ciprofloxacin achieved at expected Tmax (1 hour post-dose) following oral dosing to steady-state ranged from 0.98 to 1.69 mcg/mL. Mean steady-state trough concentrations at 12 hours post-dose ranged from 0.12 to 0.19 mcg/mL5. Mortality due to anthrax for animals that received a 30-day regimen of oral ciprofloxacin beginning 24 hours post-exposure was significantly lower (1/9), compared to the placebo group (9/10) [p=0.001]. The one ciprofloxacin-treated animal that died of anthrax did so following the 30-day drug administration period6.

More than 9300 persons were recommended to complete a minimum of 60 days of antibiotic prophylaxis against possible inhalational exposure to B. anthracis during 2001. Ciprofloxacin was recommended to most of those individuals for all or part of the prophylaxis regimen. Some persons were also given anthrax vaccine or were switched to alternative antibiotics. No one who received ciprofloxacin or other therapies as prophylactic treatment subsequently developed inhalational anthrax. The number of persons who received ciprofloxacin as all or part of their post-exposure prophylaxis regimen is unknown.

Among the persons surveyed by the Centers for Disease Control and Prevention, over 1000 reported receiving ciprofloxacin as sole post-exposure prophylaxis for inhalational anthrax. Gastrointestinal adverse events (nausea, vomiting, diarrhea, or stomach pain), neurological adverse events (problems sleeping, nightmares, headache, dizziness or lightheadedness) and musculoskeletal adverse events (muscle or tendon pain and joint swelling or pain) were more frequent than had been previously reported in controlled clinical trials. This higher incidence, in the absence of a control group, could be explained by a reporting bias, concurrent medical conditions, other concomitant medications, emotional stress or other confounding factors, and/or a longer treatment period with ciprofloxacin. Because of these factors and limitations in the data collection, it is difficult to evaluate whether the reported symptoms were drug-related.

Bedford Laboratories™ Bedford, OH 44146 November 2007 CPRO-P02

Disclaimer

The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material. PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER.

Sandrena 0, Sandrena

Hormone Replacement Therapy (HRT) for oestrogen deficiency symptoms in postmenopausal women.

The experience of treating women more than 65 years old is limited.

4.2 Posology and method of administration

Sandrena is a gel for transdermal use. Sandrena can be used for continuous or cyclical treatment.

The usual starting dose is 1.0 mg estradiol (1.0 g gel) daily but the selection of the initial dose can be based on the severity of the patient's symptoms. Depending on the clinical response, the dosage can be readjusted after 2-3 cycles individually from 0.5 g to 1.5 g per day, corresponding to 0.5 to 1.5 mg estradiol per day. For initiation and continuation of treatment of postmenopausal symptoms, the lowest effective dose for the shortest duration (see also section 4.4) should be used.

In patients with an intact uterus, it is recommended to combine Sandrena with an adequate dose of progestagen, for adequate duration for at least 12-14 consecutive days per month/28 day cycle or to oppose oestrogen-stimulated hyperplasia of the endometrium. Unless there is a previous diagnosis of endometriosis, it is not recommended to add a progestagen in hysterectomised women.

In women who are not using hormone replacement therapy (HRT), or women transferring from continuous combined HRT product, treatment with Sandrena may be started on any convenient day. In women transferring from a continuous sequential HRT regimen, treatment should begin the day following completion of the prior regimen.

If the patient has forgotten to apply one dose, the forgotten dose is to be applied as soon as possible if the dose is not more than 12 hours late. If the dose is more than 12 hours late, the dose should be forgotten and continue as normal. Forgetting a dose may increase the likelihood of break-through bleeding and spotting.

There is no relevant indication for use of Sandrena in children.

Method of administration

Apply on dry and clean skin.

The Sandrena dose is applied once daily on the skin of the lower trunk of the right or left thigh, on alternate days. The application surface should be 1-2 times the size of a hand. Sandrena should not be applied on the breasts, on the face or irritated skin. After application the gel should be allowed to dry for a few minutes and the application site should not be washed within 1 hour. Contact of the gel with eyes should be avoided. Hands should be washed after application.

- Known, past or suspected breast cancer

- Known or suspected oestrogen-dependent malignant tumours (e. g. endometrial cancer)

- Undiagnosed genital bleeding

- Untreated endometrial hyperplasia

- Previous or current venous thromboembolism (deep venous thrombosis, pulmonary embolism)

- Known thrombophilic disorders (e. g. protein C, protein S, or antithrombin deficiency, see section 4.4)

- Active or recent arterial thromboembolic disease (e. g. angina, myocardial infarction)

- Acute liver disease or a history of liver disease as long as liver functions have failed to return to normal

- Known hypersensitivity to the active substance or to any of the excipients listed in section 6.1

4.4 Special warnings and precautions for use

For the treatment of postmenopausal symptoms, HRT should only be initiated for symptoms that adversely affect quality of life. In all cases, a careful appraisal of the risks and benefits should be undertaken at least annually and HRT should only be continued as long as the benefit outweighs the risk.

Evidence regarding the risks associated with HRT in the treatment of premature menopause is limited. Due to the low level of absolute risk in younger women, however, the balance of benefits and risks for these women may be more favourable than in older women.

Before initiating or reinstituting hormone replacement therapy (HRT), a complete personal and family medical history should be taken. Physical (including pelvic and breast) examination should be guided by this and by the contraindications and warnings for use. During treatment, periodic check-ups are recommended of a frequency and nature adapted to the individual woman. Women should be advised what changes in their breasts should be reported to their doctor or nurse (see 'Breast cancer' below). Investigations including appropriate imaging tools, e. g. mammography, should be carried out in accordance with currently accepted screening practices, modified to the clinical needs of the individual.

Conditions which need supervision

If any of the following conditions are present, have occurred previously and/or have been aggravated during pregnancy or previous hormone treatment, the patient should be closely supervised. It should be taken into account that these conditions may recur or be aggravated during treatment with Sandrena, in particular:

- Leiomyoma (uterine fibroids) or endometriosis

- Risk factors for thromboembolic disorders (see below)

- Risk factors for oestrogen dependent tumours, e. g. 1st degree heredity for breast cancer

- Liver disorders (e. g. liver adenoma)

- Diabetes mellitus with or without vascular involvement

- Migraine or (severe) headache

- Systemic lupus erythematosus

- A history of endometrial hyperplasia (see below)

Reasons for immediate withdrawal of therapy:

Therapy should be discontinued in case a contra-indication is discovered and in the following situations:

- Jaundice or deterioration in liver function

- Significant increase in blood pressure

- New onset of migraine-type headache

Endometrial hyperplasia and carcinoma

- In women with an intact uterus the risk of endometrial hyperplasia and carcinoma is increased when oestrogens are administered alone for prolonged periods. The reported increase in endometrial cancer risk among oestrogen-only users varies from 2-to 12-fold greater compared with non-users, depending on the duration of treatment and oestrogen dose (see section 4.8). After stopping treatment risk may remain elevated for at least 10 years.

- The addition of a progestagen cyclically for at least 12 days per month/28 day cycle or continuous combined oestrogen-progestagen therapy in non-hysterectomised women prevents the excess risk associated with oestrogen-only HRT.

- Breakthrough bleeding and spotting may occur during the first months of treatment. If breakthrough bleeding or spotting appears after some time on therapy, or continues after treatment has been discontinued, the reason should be investigated, which may include endometrial biopsy to exclude endometrial malignancy.

- Unopposed oestrogen stimulation may lead to premalignant or malignant transformation in the residual foci of endometriosis. Therefore, the addition of progestagens to oestrogen replacement therapy should be considered in women who have undergone hysterectomy because of endometriosis, if they are known to have residual endometriosis.

The overall evidence suggests an increased risk of breast cancer in women taking combined oestrogen-progestagen and possibly also oestrogen-only HRT, that is dependent on the duration of taking HRT.

Combined oestrogen-progestagen therapy:

- The randomised placebo-controlled trial (the Women's Health Initiative study (WHI)), and epidemiological studies are consistent in finding an increased risk of breast cancer in women taking combined oestrogen-progestagen for HRT that becomes apparent after about 3 years (see section 4.8).

- The WHI trial found no increase in the risk of breast cancer in hysterectomised women using oestrogen-only HRT. Observational studies have mostly reported a small increase in risk of having breast cancer diagnosed that is substantially lower than that found in users of oestrogen - progestagen combinations (see section 4.8).

The excess risk becomes apparent within a few years of use but returns to baseline within a few (at most five) years after stopping treatment.

HRT, especially oestrogen - progestagen combined treatment, increases the density of mammographic images which may adversely affect the radiological detection of breast cancer.

Ovarian cancer is much rarer than breast cancer. Epidemiological evidence from a large meta-analysis suggests a slightly increased risk in women taking oestrogen-only or combined oestrogen-progestagen HRT, which becomes apparent within 5 years of use and diminishes over time after stopping.

Some other studies, including the WHI trial, suggest that use of combined HRTs may be associated with a similar or slightly smaller risk (see Section 4.8).

- HRT is associated with a 1.3–3 fold risk of developing venous thromboembolism (VTE), i. e. deep vein thrombosis or pulmonary embolism. The occurrence of such an event is more likely in the first year of HRT than later (see section 4.8).

- Patients with a history of VTE or known thrombophilic states have an increased risk of VTE and HRT may add to this risk. HRT is therefore contraindicated in these patients (see section 4.3).

- Generally recognised risk factors for VTE include, use of oestrogens, older age, major surgery, prolonged immobilisation, obesity (BMI > 30 kg/m2), pregnancy/postpartum period, systemic lupus erythematosus (SLE), and cancer. There is no consensus about the possible role of varicose veins in VTE.

- As in all postoperative patients, prophylactic measures need to be considered to prevent VTE following surgery. If prolonged immobilisation is to follow elective surgery, temporarily stopping HRT 4 to 6 weeks earlier is recommended. Treatment should not be restarted until the woman is completely mobilised.

- In women with no personal history of VTE but with a first degree relative with a history of thrombosis at young age, screening may be offered after careful counselling regarding its limitations (only a proportion of thrombophilic defects are identified by screening). If a thrombophilic defect is identified which segregates with thrombosis in family members or if the defect is 'severe' (e. g. antithrombin, protein S, or protein C deficiencies or a combination of defects) HRT is contraindicated.

- Women already on chronic anticoagulant treatment require careful consideration of the benefit-risk of use of HRT.

- If VTE develops after initiating therapy, the drug should be discontinued. Patients should be told to contact their doctors immediately when they are aware of a potential thromboembolic symptom (e. g. painful swelling of a leg, sudden pain in the chest, dyspnoea).

Coronary artery disease (CAD)

There is no evidence from randomised controlled trials of protection against myocardial infarction in women with or without existing CAD who received combined oestrogen-progestagen or oestrogen-only HRT.

Combined oestrogen-progestagen therapy

The relative risk of CAD during use of combined oestrogen+progestagen HRT is slightly increased. As the baseline absolute risk of CAD is strongly dependent on age, the number of extra cases of CAD due to oestrogen+progestagen use is very low in healthy women close to menopause, but will rise with more advanced age.

Randomised controlled data found no increased risk of CAD in hysterectomised women using oestrogen-only therapy.

Combined oestrogen-progestagen and oestrogen-only therapy are associated with an up to 1.5-fold increase in risk of ischaemic stroke. The relative risk does not change with age or time since menopause. However, as the baseline risk of stroke is strongly age-dependent, the overall risk of stroke in women who use HRT will increase with age (see section 4.8).

- Oestrogens may cause fluid retention and, therefore patients with cardiac or renal dysfunction should be carefully observed. Patients with terminal renal insufficiency should be closely observed.

- Women with pre-existing hypertriglyceridemia should be followed closely during oestrogen replacement or hormone replacement therapy, since rare cases of large increases of plasma triglycerides leading to pancreatitis have been reported with oestrogen therapy in this condition.

- Oestrogens increase thyroid binding globulin (TBG), leading to increased circulating total thyroid hormone, as measured by protein-bound iodine (PBI), T4 levels (by column or by radio-immunoassay) or T3 levels (by radio-immunoassay). T3 resin uptake is decreased, reflecting the elevated TBG. Free T4 and free T3 concentrations are unaltered. Other binding proteins may be elevated in serum, i. e. corticoid binding globulin (CBG), sex-hormone-binding globulin (SHBG) leading to increased circulating corticosteroids and sex steroids, respectively. Free or biological active hormone concentrations are unchanged. Other plasma proteins may be increased (angiotensinogen/renin substrate, alpha-1-antitrypsin, ceruloplasmin).

- Chloasma may occasionally occur, especially in women with a history of chloasma gravidarum. Women with a tendency to chloasma should minimise exposure to the sun or ultraviolet radiation whilst taking HRT.

- HRT use does not improve cognitive function. There is some evidence of increased risk of probable dementia in women who start using continuous combined or oestrogen-only HRT after the age of 65.

This medicinal product contains propylene glycol and therefore may cause skin irritation.

4.5 Interaction with other medicinal products and other forms of interaction

The metabolism of oestrogens may be increased by concomitant use of substances known to induce drug-metabolising enzymes, specifically cytochrome P450 enzymes, such as anticonvulsants (e. g. phenobarbital, phenytoin, carbamazepine) and anti-infectives (e. g. rifampicin, rifabutin, nevirapine, efavirenz).

Ritonavir and nelfinavir, although known as strong inhibitors, by contrast exhibit inducing properties when used concomitantly with steroid hormones. Herbal preparations containing St. John's wort ( Hypericum perforatum ) may induce the metabolism of oestrogens.

At transdermal administration, the first-pass effect in the liver is avoided and, thus, transdermally applied oestrogens might be less affected than oral hormones by enzyme inducers.

Clinically, an increased metabolism of oestrogens and progestagens may lead to decreased effect and changes in the uterine bleeding profile.

4.6 Fertility, pregnancy and lactation

Sandrena is not indicated during pregnancy. If pregnancy occurs during medication with Sandrena, treatment should be withdrawn immediately.

The results of most epidemiological studies to date relevant to inadvertent foetal exposure to oestrogens indicate no teratogenic or foetotoxic effects.

Sandrena is not indicated during lactation.

4.7 Effects on ability to drive and use machines

No studies on the effects on the ability to drive and use machines have been performed.

4.8 Undesirable effects

During the first few months of treatment, breakthrough bleeding, spotting and breast tenderness or enlargement can occur. These are usually temporary and normally disappear after continued treatment.

Adverse drug reactions were recorded e. g. in 3 phase III clinical studies (n=611 women at risk) and were included in the table when considered at least possibly related to treatment with 50mcg/day estradiol or 100mcg/day estradiol, respectively, following transdermal application.

The table below lists adverse drug reactions recorded in clinical studies as well as adverse drug reactions reported post-marketing. The experience of adverse drug reactions is overall expected in 76 % of the patients. Adverse drug reactions appearing in > 10 % of patients in clinical trials were application site reactions and breast pain.

Undesirable effects according to organ system class associated with transdermal estradiol treatment are presented in the table below.

Organ system class

Common ADRs, (≥1/100, < 1/10)

*2 Taken from baseline incidence rates in developed countries.

# Overall risk ratio. The risk ratio is not constant but will increase with increasing duration on use.

Note: Since the background incidence of breast cancer differs by EU country, the number of additional cases of breast cancer will also change proportionately.

US WHI studies - additional risk of breast cancer after 5 years' use

Incidence per 1,000 women in placebo arm over 5 years

Risk ratio & 95% CI

Additional cases per 1,000 HRT users over 5 years (95% CI)

CEE+MPA oestrogen & progestagen ‡

*3 WHI study in women with no uterus, which did not show an increase in risk of breast cancer.

‡When the analysis was restricted to women who had not used HRT prior to the study there was no increased risk apparent during the first 5 years of treatment: after 5 years the risk was higher than in non-users.

Endometrial cancer risk

Postmenopausal women with a uterus

The endometrial cancer risk is about 5 in every 1,000 women with a uterus not using HRT. In women with a uterus, use of oestrogen-only HRT is not recommended because it increases the risk of endometrial cancer (see section 4.4).

Depending on the duration of oestrogen-only use and oestrogen dose, the increase in risk of endometrial cancer in epidemiology studies varied from between 5 and 55 extra cases diagnosed in every 1,000 women between the ages of 50 and 65.

Adding a progestagen to oestrogen-only therapy for at least 12 days per cycle can prevent this increased risk. In the Million Women Study the use of five years of combined (sequential or continuous) HRT did not increase risk of endometrial cancer (RR of 1.0 [0.8–1.2]).

Ovarian cancer risk

Use of oestrogen-only or and combined oestrogen - progestagen HRT has been associated with a slightly increased risk of having ovarian cancer diagnosed (see Section 4.4).

A meta-analysis from 52 epidemiological studies reported an increased risk of ovarian cancer in women currently using HRT compared to women who have never used HRT (RR 1.43, 95% CI 1.31-1.56). For women aged 50 to 54 years taking 5 years of HRT this results in about 1 extra case per 2,000 users. In women aged 50 to 54 who are not taking HRT, about 2 women in 2000 will be diagnosed with ovarian cancer over a 5-year period.

Risk of venous thromboembolism

HRT is associated with a 1.3–3-fold increased relative risk of developing venous thromboembolism (VTE), i. e. deep vein thrombosis or pulmonary embolism. The occurrence of such an event is more likely in the first year of using HRT (see section 4.4). Results of the WHI studies are presented:

WHI Studies - Additional risk of VTE over 5 years' use

Age range (years)

Incidence per 1,000 women in placebo arm over 5 years

*4 Study in women with no uterus.

Risk of coronary artery disease

- The risk of coronary artery disease is slightly increased in users of combined oestrogen-progestagen HRT over the age of 60 (see section 4.4).

Risk of ischaemic stroke

- The use of oestrogen-only and oestrogen + progestagen therapy is associated with an up to 1.5 fold increased relative risk of ischaemic stroke. The risk of haemorrhagic stroke is not increased during use of HRT.

- This relative risk is not dependent on age or on duration of use, but as the baseline risk is strongly age-dependent, the overall risk of stroke in women who use HRT will increase with age, see section 4.4.

WHI studies combined - Additional risk of ischaemic stroke*5 over 5 years' use.

Age range (years)

Incidence per 1,000 women in placebo arm over 5 years

*5 no differentiation was made between ischaemic and haemorrhagic stroke.

Reporting of suspected adverse reactions

Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at: www. mhra. gov. uk/yellowcard.

Generally, oestrogens are well tolerated even in massive doses. Acute toxicity studies did not indicate a risk of acute adverse effects in case of inadvertent intake of a multiple of the daily therapeutic dose. Nausea, vomiting and withdrawal bleeding may occur in some women.

Overdose effects generally lead to breast tenderness, abdominal or pelvis swelling, anxiety, irritability. These symptoms disappear when the treatment is stopped or when the dose is reduced.

Overdosage is unlikely with transdermal application. There is no specific antidote and treatment should be symptomatic. The gel should be washed.

5. Pharmacological properties

5.1 Pharmacodynamic properties

Pharmacotherapeutic group: Natural and semisynthetic oestrogens, plain, ATC code G03CA03.

The active ingredient in Sandrena, synthetic 17β-estradiol, is chemically and biologically identical to endogenous human estradiol. It substitutes for the loss of oestrogen production in menopausal women, and alleviates menopausal symptoms.

As oestrogens promote the growth of the endometrium, unopposed oestrogens increase the risk of endometrial hyperplasia and cancer. The addition of a progestagen greatly reduces the oestrogen induced risk of endometrial hyperplasia in non-hysterectomised women.

Clinical trial information

The pharmacodynamics of Sandrena are similar to those of oral oestrogens, but the major difference to oral administration lies in the pharmacokinetic profile. The clinical efficacy of Sandrena in the treatment of menopausal symptoms is comparable to that of peroral oestrogen.

Relief of oestrogen-deficiency symptoms and bleeding patterns

Relief of menopausal symptoms was achieved during the first few weeks of treatment.

5.2 Pharmacokinetic properties

Sandrena is an alcohol-based estradiol gel. When applied to the skin the alcohol evaporates rapidly and estradiol is absorbed through the skin into the circulation. Application of Sandrena on area of 200-400 cm 2 (size of one to two hands) does not affect the amount of estradiol absorbed. However, if Sandrena is applied to larger area absorption decreases significantly. To some extent, however, the estradiol is stored in the subcutaneous tissue from where it is released gradually into circulation. Percutaneous administration circumvents the hepatic first-pass metabolism. For these reasons, the fluctuations in the plasma oestrogen concentrations with Sandrena are less pronounced than peroral oestrogen.

Percutaneous doses of 0.5, 1.0 and 1.5 mg of estradiol (0.5, 1.0 and 1.5 g Sandrena) result in mean C max concentrations in plasma of 143, 247 and 582 pmol/L, respectively. The corresponding mean C average concentrations over the dosing interval are 75, 124 and 210 pmol/L. The corresponding mean C min concentrations were 92, 101 and 152 pmol/L, respectively. During Sandrena treatment the estradiol/oestrone ratio remains between 0.4 and 0.7, while for oral oestrogen treatment it usually drops to less than 0.2.

The mean estradiol exposure at steady state of Sandrena is 82 per cent compared with an equivalent oral dose of estradiol valerate. Otherwise the metabolism and excretion of transdermal estradiol follow the fate of natural oestrogens.

5.3 Preclinical safety data

Estradiol is a natural female hormone with an established clinical use, therefore no toxicological studies have been performed with Sandrena. The necessary studies on the irritant effects of the gel were studied in rabbits and skin sensitisation in guinea pig. Based on the results from these studies it can be concluded that Sandrena very infrequently could cause mild skin irritation. Skin irritation can be reduced by daily change of the application site.

6. Pharmaceutical particulars

6.1 List of excipients

Cefixime Medical Facts From, Eficef

cefixime

cephradine (Velosef); and others.

To make sure cefixime is safe for you, tell your doctor if you are allergic to any drugs, especially penicillins.

FDA pregnancy category B. Cefixime is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether cefixime passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

The cefixime suspension (liquid) contains sucrose. Talk to your doctor before using this form of cefixime if you have diabetes.

How should I take cefixime?

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Take this medicine with a full glass of water.

Cefixime works best if you take it with a meal or within 30 minutes of a meal.

The cefixime chewable tablet must be chewed before you swallow it.

Do not crush, chew, or break an extended-release tablet . Swallow it whole.

Shake the oral suspension (liquid) well just before you measure a dose. Measure the liquid with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

This medication can cause unusual results with certain lab tests for glucose (sugar) in the urine. Tell any doctor who treats you that you are using cefixime.

Use this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Cefixime will not treat a viral infection such as the common cold or flu.

Store the tablets and capsules at room temperature away from moisture, heat, and light.

Store the oral liquid in the refrigerator. Throw away any unused medication after 14 days.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking cefixime?

Avoid using antacids within 1 hour before or after taking cefixime. Antacids can make it harder for your body to absorb cefixime.

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, stop taking cefixime and call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

Cefixime side effects

Get emergency medical help if you have any of these signs of an allergic reaction . hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

diarrhea that is watery or bloody;

jaundice (yellowing of the skin or eyes);

swelling, rapid weight gain, little or no urinating;

fever, swollen gums, painful mouth sores, easy bruising, unusual bleeding;

pale or yellowed skin, dark colored urine, confusion or weakness; or

severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Common side effects may include:

stomach pain, nausea, upset stomach, gas;

mild itching or rash;

vaginal itching or discharge.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Cefixime dosing information

Usual Adult Dose for Urinary Tract Infection:

Uncomplicated infections: 400 mg orally once a day or 200 mg orally every 12 hours

Usual Adult Dose for Otitis Media:

Oral suspension, chewable tablets: 400 mg orally once a day or 200 mg orally every 12 hours

Usual Adult Dose for Tonsillitis/Pharyngitis:

400 mg orally once a day or 200 mg orally every 12 hours

Comments: - Penicillin is the usual drug of choice for the treatment of Streptococcus pyogenes infections. Cefixime is generally effective in the eradication of S pyogenes from the nasopharynx; however, its efficacy in the subsequent prevention of rheumatic fever has not been established.

Usual Adult Dose for Bronchitis:

Acute exacerbations of chronic bronchitis: 400 mg orally once a day or 200 mg orally every 12 hours

Usual Adult Dose for Gonococcal Infection -- Uncomplicated:

Uncomplicated cervical/urethral infections: 400 mg orally as a single dose

Centers for Disease Control and Prevention (CDC) recommendations: Uncomplicated infections of the cervix, urethra, or rectum: 400 mg orally as a single dose plus (azithromycin [preferred] or doxycycline) plus test-of-cure in 1 week

Comments: - The CDC regimen is recommended as an alternative if ceftriaxone is not available. - The patient's sexual partner(s) should also be evaluated/treated.

Usual Adult Dose for Gonococcal Infection -- Disseminated:

(Not approved by FDA)

CDC recommendations: 400 mg orally twice a day

Comments: - Initial therapy for disseminated gonococcal infections requires parenteral therapy which should be continued for 24 to 48 hours after clinical improvement is observed. Oral therapy may then be administered to complete a total course of at least 1 week. - Doxycycline therapy for 7 days (if not pregnant) or single-dose azithromycin is also recommended to treat possible concurrent chlamydial infection. - The patient's sexual partner(s) should also be evaluated/treated.

Usual Adult Dose for STD Prophylaxis:

(Not approved by FDA)

CDC recommendations for sexual assault victims: 400 mg orally as a single dose plus metronidazole plus (azithromycin or doxycycline)

Usual Pediatric Dose for Otitis Media:

Oral suspension, chewable tablets: 6 months to 12 years (weighing 45 kg or less): 8 mg/kg orally once a day or 4 mg/kg orally every 12 hours Children weighing more than 45 kg or older than 12 years: 400 mg orally once a day or 200 mg orally every 12 hours

Usual Pediatric Dose for Urinary Tract Infection:

Uncomplicated infections: 6 months to 12 years (weighing 45 kg or less): Oral suspension, chewable tablets: 8 mg/kg orally once a day or 4 mg/kg orally every 12 hours

Children weighing more than 45 kg or older than 12 years: 400 mg orally once a day or 200 mg orally every 12 hours

Usual Pediatric Dose for Tonsillitis/Pharyngitis:

6 months to 12 years (weighing 45 kg or less): Oral suspension, chewable tablets: 8 mg/kg orally once a day or 4 mg/kg orally every 12 hours

Children weighing more than 45 kg or older than 12 years: 400 mg orally once a day or 200 mg orally every 12 hours

Comments: - Penicillin is the usual drug of choice for the treatment of Streptococcus pyogenes infections. Cefixime is generally effective in the eradication of S pyogenes from the nasopharynx; however, its efficacy in the subsequent prevention of rheumatic fever has not been established.

Usual Pediatric Dose for Bronchitis:

Acute exacerbations of chronic bronchitis: 6 months to 12 years (weighing 45 kg or less): Oral suspension, chewable tablets: 8 mg/kg orally once a day or 4 mg/kg orally every 12 hours

Children weighing more than 45 kg or older than 12 years: 400 mg orally once a day or 200 mg orally every 12 hours

Usual Pediatric Dose for Gonococcal Infection -- Uncomplicated:

(Not approved by FDA)

American Academy of Pediatrics recommendations: 8 years or older weighing 45 kg or more: 400 mg orally as a single dose

CDC recommendations: Uncomplicated infections of the cervix, urethra, or rectum in adolescents: 400 mg orally as a single dose plus (azithromycin [preferred] or doxycycline) plus test-of-cure in 1 week

Comments: - The CDC regimen is recommended as an alternative if ceftriaxone is not available. - The patient's sexual partner(s) should also be evaluated/treated.

Usual Pediatric Dose for Gonococcal Infection -- Disseminated:

(Not approved by FDA)

CDC recommendations for adolescents: 400 mg orally twice a day

Comments: - Initial therapy for disseminated gonococcal infections requires parenteral therapy which should be continued for 24 to 48 hours after clinical improvement is observed. Oral therapy may then be administered to complete a total course of at least 1 week. - Doxycycline therapy for 7 days (if not pregnant) or single-dose azithromycin is also recommended to treat possible concurrent chlamydial infection. - The patient's sexual partner(s) should also be evaluated/treated.

Usual Pediatric Dose for STD Prophylaxis:

(Not approved by FDA)

CDC recommendations for adolescent sexual assault victims: 400 mg orally as a single dose plus metronidazole plus (azithromycin or doxycycline)

What other drugs will affect cefixime?

Other drugs may interact with cefixime, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

More about cefixime

Consumer resources

Professional resources

Related treatment guides

Where can I get more information?

Your pharmacist can provide more information about cefixime.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 5.05. Revision Date: 2013-06-26, 10:58:29 AM.

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Methyltheobromine

Methyltheobromine Brand names, Methyltheobromine Analogs

Methyltheobromine Brand Names Mixture

(Extra Strength) Acetaminophen, Caffeine & 8mg Codeine Phosphate Caplets (Acetaminophen + Caffeine + Codeine Phosphate)

217 (Acetylsalicylic Acid + Caffeine Citrate)

217 Strong Tab (Acetylsalicylic Acid + Caffeine Citrate)

222 Tablet (Acetylsalicylic Acid + Caffeine Citrate + Codeine Phosphate)

282 Mep (Acetylsalicylic Acid + Caffeine Citrate + Codeine Phosphate + Meprobamate)

282 Mep Tab (Acetylsalicylic Acid + Caffeine Citrate + Codeine Phosphate + Meprobamate)

282 Tab (Acetylsalicylic Acid + Caffeine Citrate + Codeine Phosphate)

282 Tablets (Acetylsalicylic Acid + Caffeine Citrate + Codeine Phosphate)

292 Tab (Acetylsalicylic Acid + Caffeine Citrate + Codeine Phosphate)

292 Tablets (Acetylsalicylic Acid + Caffeine Citrate + Codeine Phosphate)

692 Tab (Acetylsalicylic Acid + Caffeine + Dextropropoxyphene Hydrochloride)

692 Tablet (Acetylsalicylic Acid + Caffeine + Dextropropoxyphene Hydrochloride)

a & C Tablets with Codeine 15mg (Acetylsalicylic Acid + Caffeine + Codeine Phosphate)

a & C Tablets with Codeine 30mg (Acetylsalicylic Acid + Caffeine + Codeine Phosphate)

a C and C Tab 0.125gr (Acetylsalicylic Acid + Caffeine + Codeine Phosphate)

A. C. & C 8mg Tab (Acetylsalicylic Acid + Caffeine + Codeine Phosphate)

A. C.& C Tablets (Acetylsalicylic Acid + Caffeine + Codeine Phosphate)

Ac and C Tab 1/8gr (Acetylsalicylic Acid + Caffeine + Codeine Phosphate)

Ac&C Tablets (Acetylsalicylic Acid + Caffeine + Codeine Phosphate)

Acet 2 (Acetaminophen + Caffeine + Codeine Phosphate)

Acet 3 (Acetaminophen + Caffeine + Codeine Phosphate)

Acetaminophen 300 Mg with Caffeine & Codeine Caplet (Acetaminophen + Caffeine + Codeine Phosphate)

Acetaminophen 500mg Cmpd Tab W Codeine (Acetaminophen + Caffeine + Codeine Phosphate)

Acetaminophen Caffeine & 8mg Cod Phos Tab (Acetaminophen + Caffeine + Codeine (Codeine Phosphate))

Acetaminophen Caffeine & 8mg Cod. Phos. Tab (Acetaminophen + Caffeine + Codeine Phosphate)

Acetaminophen Compound Caplets with Codeine (Acetaminophen + Caffeine + Codeine Phosphate)

Acetaminophen Compound Tablets with Codeine (Acetaminophen + Caffeine + Codeine Phosphate)

Acetaminophen Compound Tablets with Codeine 8mg (Acetaminophen + Caffeine + Codeine Phosphate)

Acetaminophen Extra Strength W Caf & Codeine (Acetaminophen + Caffeine + Codeine Phosphate)

Acetaminophen W Caffeine and Codeine (Acetaminophen + Caffeine + Codeine Phosphate)

Acetaminophen W Codeine Tab (Acetaminophen + Caffeine + Codeine Phosphate)

Acetaminophen with Codeine - Caplet (Acetaminophen + Caffeine + Codeine Phosphate)

Acetaminophen, Caffeine & 8mg Codeine Phosphate (Acetaminophen + Caffeine + Codeine Phosphate)

Acetaminophen, Caffeine & 8mg Codeine Phosphate Tablets (Acetaminophen + Caffeine + Codeine Phosphate)

Acetaminophen, Caffeine and 8 Mg of Codeine Phosphate Tablets (Acetaminophen + Caffeine + Codeine Phosphate)

Acetaminophen, Caffeine, and 8mg of Codeine Phosphate Tablets (Acetaminophen + Caffeine + Codeine Phosphate)

Acetaminophene Codeine Et Cafeine Caplets (Acetaminophen + Caffeine Citrate + Codeine Phosphate)

Acetaminophene Codeine Et Cafeine Fort (Acetaminophen + Caffeine Citrate + Codeine Phosphate)

Acetylsalicylic Acid Caffeine & 8mg Cod Phos (Acetylsalicylic Acid + Caffeine + Codeine (Codeine Phosphate))

Acetylsalicylic Acid, Caffeine & 8 Mg Codeine Phosphate Tablets (Acetylsalicylic Acid + Caffeine + Codeine Phosphate)

Acetylsalicylic Acid, Caffeine and 8mg Codeine Phosphate (Acetylsalicylic Acid + Caffeine + Codeine Phosphate)

Alka-Seltzer Morning Relief (Acetylsalicylic Acid + Caffeine)

Anacin Caplet (Acetylsalicylic Acid + Caffeine)

Anacin Caplets (Acetylsalicylic Acid + Caffeine)

Anacin Extra Strength Caplet (Acetylsalicylic Acid + Caffeine)

Anacin Extra Strength Tablet (Acetylsalicylic Acid + Caffeine)

Anacin Tab (Acetylsalicylic Acid + Caffeine)

Anacin Tablet (Acetylsalicylic Acid + Caffeine)

Anacin with Codeine Tab (Acetylsalicylic Acid + Caffeine + Codeine Phosphate)

Antidol Tablets (Acetylsalicylic Acid + Caffeine)

Arco Pain Tab (Acetylsalicylic Acid + Caffeine Citrate)

Asa, Caffeine & 8mg Codeine Phosphate (Acetylsalicylic Acid + Caffeine + Codeine Phosphate)

Astone Cap (Acetylsalicylic Acid + Caffeine)

Atasol 15 Tab (Acetaminophen + Caffeine Citrate + Codeine Phosphate)

Atasol 30 Tab (Acetaminophen + Caffeine Citrate + Codeine Phosphate)

Atasol 8 Tab (Acetaminophen + Caffeine Citrate + Codeine Phosphate)

C T Acetylsalicylic Acid Codeine and Caf Tab (Acetylsalicylic Acid + Caffeine + Codeine Phosphate)

C-2 Buffered with Codeine (Acetylsalicylic Acid + Caffeine + Codeine Phosphate)

C2 Buffered Tab (Acetylsalicylic Acid + Aluminum Hydroxide + Caffeine + Magnesium Hydroxide)

C2 Buffered with Codeine Tab (Acetylsalicylic Acid + Aluminum Hydroxide + Caffeine + Codeine Phosphate + Magnesium Hydroxide)

C2 Tab with Codeine (Acetylsalicylic Acid + Caffeine + Codeine Phosphate)

Cafergot Pb Sup (Belladonna + Caffeine + Ergotamine (Ergotamine Tartrate) + Pentobarbital)

Cafergot Pb Tab (Belladonna + Caffeine + Ergotamine (Ergotamine Tartrate) + Pentobarbital Sodium)

Cafergot Sup (Caffeine + Ergotamine Tartrate)

Cafergot Tab (Caffeine + Ergotamine Tartrate)

Calmine Tab (Acetylsalicylic Acid + Caffeine)

Codamin No2 (Acetaminophen + Caffeine + Codeine Phosphate)

Codamin No3 (Acetaminophen + Caffeine + Codeine Phosphate)

Codaminophen Tab 1/8gr (Acetaminophen + Caffeine + Codeine Phosphate)

Corytab (Acetaminophen + Caffeine + Diphenylpyraline Hydrochloride)

Cotabs (Acetaminophen + Caffeine Citrate + Codeine Phosphate)

Darvon N Compound Pulvule 405 (Acetylsalicylic Acid + Caffeine + Dextropropoxyphene Napsylate)

Dolomine 37 (Acetylsalicylic Acid + Caffeine)

Dristan Capsules (Acetylsalicylic Acid + Caffeine + Chlorpheniramine Maleate + Phenylpropanolamine Hydrochloride)

Emercidin D Tab (Acetaminophen + Caffeine + Diphenylpyraline Hydrochloride + Phenylpropanolamine Hydrochloride)

Emertabs Tab (Acetaminophen + Caffeine + Phenylpropanolamine Hydrochloride)

Ergodryl Cap (Caffeine Citrate + Diphenhydramine Hydrochloride + Ergotamine Tartrate)

Excedrin (Acetaminophen + Caffeine)

Excedrin Extra-Strength (Acetaminophen + Caffeine)

Excedrin Tab (Acetaminophen + Caffeine)

Exdol 15tab (Acetaminophen + Caffeine Citrate + Codeine Phosphate)

Exdol 30tab (Acetaminophen + Caffeine Citrate + Codeine Phosphate)

Exdol 8 Tab (Acetaminophen + Caffeine Citrate + Codeine Phosphate)

Exdol-15 Tablets (Acetaminophen + Caffeine Citrate + Codeine Phosphate)

Exdol-30 Tablets (Acetaminophen + Caffeine Citrate + Codeine Phosphate)

Exdol-8 Tablets (Acetaminophen + Caffeine Citrate + Codeine Phosphate)

Extra Strength Midol (Acetylsalicylic Acid + Caffeine)

Fiorinal C1/2 Cap (Acetylsalicylic Acid + Butalbital + Caffeine + Codeine Phosphate)

Fiorinal C1/4 Cap (Acetylsalicylic Acid + Butalbital + Caffeine + Codeine Phosphate)

Fiorinal Cap (Acetylsalicylic Acid + Butalbital + Caffeine)

Fiorinal Tab (Acetylsalicylic Acid + Butalbital + Caffeine)

Gravergol Capsules (Caffeine + Dimenhydrinate + Ergotamine Tartrate)

Herbopyrine Tab 325mg (Acetylsalicylic Acid + Caffeine Citrate)

Instantine - Tab (Acetylsalicylic Acid + Caffeine)

Instantine - Tablets (Acetylsalicylic Acid + Caffeine)

Instantine Tab (Acetylsalicylic Acid + Caffeine)

Madelon (Acetylsalicylic Acid + Caffeine)

Megral Tabs (Caffeine + Cyclizine Hydrochloride + Ergotamine Tartrate)

Midol - Caplet (Acetylsalicylic Acid + Caffeine + Cinnamedrine)

Midol Extra Strength Gelcaps (Acetaminophen + Caffeine + Pyrilamine Maleate)

Midol Extra Strength Menstrual (Acetaminophen + Caffeine + Pyrilamine Maleate)

Midol Menstrual Formula - Caplet (Acetylsalicylic Acid + Caffeine)

Midol Multi-Symptom Caplets Extra Strength (Acetaminophen + Caffeine + Pyrilamine Maleate)

Midol Multi-Symptom Gelcap Extra Strength (Acetaminophen + Caffeine + Pyrilamine Maleate)

Midol Regular (Acetylsalicylic Acid + Caffeine)

Midol Tab (Acetylsalicylic Acid + Caffeine + Cinnamedrine)

Neo Tigol Tab (Acetylsalicylic Acid + Aluminum Hydroxide + Caffeine + Magnesium Hydroxide + Passion Flower + Valerian)

Nervine (Acetylsalicylic Acid + Caffeine)

Nervine Tab (Acetylsalicylic Acid + Caffeine)

Norgesic Forte Tab (Acetylsalicylic Acid + Caffeine + Orphenadrine Citrate)

Norgesic Tab (Acetylsalicylic Acid + Caffeine + Orphenadrine Citrate)

Novo Ac and C 8mg Tab (Acetylsalicylic Acid + Caffeine + Codeine Phosphate)

Novo-Gesic C15 (Acetaminophen + Caffeine + Codeine Phosphate)

Novo-Gesic C30 (Acetaminophen + Caffeine + Codeine Phosphate)

Novo-Gesic-C8 (Acetaminophen + Caffeine + Codeine Phosphate)

Novo-Propoxyn Compound Cap (Acetylsalicylic Acid + Caffeine + Dextropropoxyphene Hydrochloride)

Oradrine 2 Tab (Acetaminophen + Caffeine + Diphenylpyraline Hydrochloride + Phenylpropanolamine Hydrochloride)

Oradrine Tablets (Acetaminophen + Caffeine + Codeine Phosphate + Diphenylpyraline Hydrochloride + Phenylpropanolamine Hydrochloride)

Oradrine-2 Tab (Acetaminophen + Caffeine + Diphenylpyraline Hydrochloride + Phenylpropanolamine Hydrochloride)

Pain Aid (Acetylsalicylic Acid + Caffeine)

Painex Tab 0.25gr (Acetylsalicylic Acid + Caffeine Citrate + Codeine Phosphate)

Painex Tab 0.5gr (Acetylsalicylic Acid + Caffeine Citrate + Codeine Phosphate)

Ratio-Lenoltec No 1 (Acetaminophen + Caffeine + Codeine Phosphate)

Ratio-Lenoltec No 2 (Acetaminophen + Caffeine + Codeine Phosphate)

Ratio-Lenoltec No 3 (Acetaminophen + Caffeine + Codeine Phosphate)

Ratio-Tecnal (Acetylsalicylic Acid + Butalbital + Caffeine)

Ratio-Tecnal C 1/2 (Acetylsalicylic Acid + Butalbital + Caffeine + Codeine Phosphate)

Ratio-Tecnal C1/4 (Acetylsalicylic Acid + Butalbital + Caffeine + Codeine Phosphate)

Sinugex 38 (Acetaminophen + Caffeine + Diphenylpyraline Hydrochloride)

Triaminicin Colds & Flu Caplets (Acetaminophen + Caffeine + Pheniramine Maleate + Phenylpropanolamine Hydrochloride + Pyrilamine Maleate)

Trianal Capsules (Acetylsalicylic Acid + Butalbital + Caffeine)

Trianal Tablet (Acetylsalicylic Acid + Butalbital + Caffeine)

Trianal-C 1/2 Capsule (Acetylsalicylic Acid + Butalbital + Caffeine + Codeine Phosphate)

Triatec-8 Fort Tab (Acetaminophen + Caffeine Citrate + Codeine Phosphate)

Triatec-8 Tab (Acetaminophen + Caffeine Citrate + Codeine Phosphate)

Tylenol No 1 Tab (Acetaminophen + Caffeine + Codeine Phosphate)

Tylenol No.1 Caplets (Acetaminophen + Caffeine + Codeine Phosphate)

Tylenol No.1 Forte Caplets (Acetaminophen + Caffeine + Codeine Phosphate)

Tylenol No1 Forte Tablets with Codeine (Acetaminophen + Caffeine + Codeine Phosphate)

Tylenol Ultra Relief (Acetaminophen + Caffeine)

Tylenol W Codeine No2 Tab (Acetaminophen + Caffeine + Codeine Phosphate)

Tylenol W Codeine No3 Tab (Acetaminophen + Caffeine + Codeine Phosphate)

Tylenol with Codeine No. 2 - Tab (Acetaminophen + Caffeine + Codeine Phosphate)

Tylenol with Codeine No. 3 - Tab (Acetaminophen + Caffeine + Codeine Phosphate)

Ultra Headache Relief (Acetaminophen + Caffeine)

Wigraine Suppositories (Belladonna + Caffeine + Ergotamine Tartrate)

Wigraine Tab (Belladonna + Caffeine + Ergotamine Tartrate)

Methyltheobromine Chemical_Formula

Methyltheobromine RX_link

Methyltheobromine fda sheet

Methyltheobromine msds (material safety sheet)

Methyltheobromine Synthesis Reference

U. S. Pat. 2,508,545 (1950)

Methyltheobromine Molecular Weight

Methyltheobromine Melting Point

Methyltheobromine H 2 O Solubility

Methyltheobromine State

Methyltheobromine LogP

Methyltheobromine Dosage Forms

Capsule; Drops; Liquid; Pill; Tablet

Methyltheobromine Indication

For management of fatigue, orthostatic hypotension, and for the short term treatment of apnea of prematurity in infants.

Methyltheobromine Pharmacology

Caffeine, a naturally occurring xanthine derivative like theobromine and the bronchodilator theophylline, is used as a CNS stimulant, mild diuretic, and respiratory stimulant (in neonates with apnea of prematurity). Often combined with analgesics or with ergot alkaloids, caffeine is used to treat migraine and other headache types. Over the counter, caffeine is available to treat drowsiness or mild water-weight gain.

Methyltheobromine Absorption

Readily absorbed after oral or parenteral administration. The peak plasma level for caffeine range from 6-10mg/L and the mean time to reach peak concentration ranged from 30 minutes to 2 hours.

Methyltheobromine side effects and Toxicity

LD 50 =127 mg/kg (orally in mice)

Methyltheobromine Patient Information

Diclofenac Gel Indications, Side Effects, Warnings, Diclobene

Diclofenac gel

Generic Name: diclofenac (dye-KLOE-fen-ak) Brand Name: Voltaren Gel

Diclofenac gel is a nonsteroidal anti-inflammatory drug (NSAID). It may cause an increased risk of serious and sometimes fatal heart and blood vessel problems (eg, a heart attack, stroke). The risk may be greater if you already have heart problems or if you use diclofenac gel for a long time. Do not use diclofenac gel right before or after bypass heart surgery.

Diclofenac gel may cause an increased risk of serious and sometimes fatal stomach ulcers and bleeding. Elderly patients may be at greater risk. This may occur without warning signs.

Diclofenac gel is used for:

Treating pain in certain joints (eg, in the knees or hands) caused by osteoarthritis. It may also be used for other conditions as determined by your doctor.

Diclofenac gel is an NSAID. It may work by blocking certain substances in the body that are linked to inflammation. NSAIDs treat the symptoms of pain and inflammation. They do not treat the disease that causes those symptoms.

Do NOT use diclofenac gel if:

you are allergic to any ingredient in diclofenac gel

you have had a severe allergic reaction (eg, severe rash, hives, trouble breathing, growths in the nose, dizziness) to aspirin or another NSAID (eg, celecoxib, ibuprofen)

you have recently had or will be having bypass heart surgery

you have severe kidney problems

you are in the last 3 months of pregnancy

Contact your doctor or health care provider right away if any of these apply to you.

Before using diclofenac gel:

Some medical conditions may interact with diclofenac gel. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of kidney or liver problems, diabetes, or stomach or bowel problems (eg, bleeding, perforation, ulcers)

if you have a history of swelling or fluid buildup, asthma, growths in the nose (nasal polyps), or mouth inflammation

if you have high blood pressure, blood disorders (eg, porphyria), bleeding or clotting problems, heart problems (eg, heart failure), or blood vessel disease, or if you are at risk of any of these diseases

if you have poor health, dehydration or low fluid volume, low blood sodium levels, or you drink alcohol or have a history of alcohol abuse

Some MEDICINES MAY INTERACT with diclofenac gel. Tell your health care provider if you are taking any other medicines, especially any of the following:

Anticoagulants (eg, warfarin), aspirin, clopidogrel, corticosteroids (eg, prednisone), direct factor Xa inhibitors (eg, rivaroxaban), heparin, prasugrel, or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) because the risk of bleeding, including stomach bleeding, may be increased

Azole antifungals (eg, itraconazole, voriconazole), bisphosphonates (eg, risedronate), or probenecid because they may increase the risk of diclofenac gel's side effects

Rifamycins (eg, rifampin) because they may decrease diclofenac gel's effectiveness

Cyclosporine, lithium, methotrexate, oral NSAIDs (eg, ibuprofen), quinolones (eg, ciprofloxacin), or tenofovir because the risk of their side effects may be increased by diclofenac gel

Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril) or diuretics (eg, furosemide, hydrochlorothiazide) because their effectiveness may be decreased by diclofenac gel

Medicines that may harm the liver (eg, acetaminophen, ketoconazole, isoniazid, certain medicines for HIV infection, certain antibiotics or seizure medicines) because the risk of liver side effects may be increased. Ask your doctor if you are unsure if any of your medicines might harm the liver

This may not be a complete list of all interactions that may occur. Ask your health care provider if diclofenac gel may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use diclofenac gel:

Use diclofenac gel as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Diclofenac gel comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get diclofenac gel refilled.

Do not apply diclofenac gel to infected skin; open wounds; or red, swollen, or peeling skin.

Use the provided dosing card to measure your dose of diclofenac gel. Ask your pharmacist if you have any questions about how to use the dosing card or diclofenac gel.

Gently massage diclofenac gel into the skin of the affected area. Allow the medicine to dry for at least 10 minutes before you wear clothes or gloves over the treated area.

After using the dosing card, fold it in half (with the used side inside) and throw it away out of the reach of children and pets.

Wash your hands immediately after using diclofenac gel, unless your hands are part of the treated area.

Do not wrap, bandage, or apply heat to the treated area.

Do not shower, bathe, or wash the treated area for at least 1 hour after you use diclofenac gel.

If you miss a dose of diclofenac gel, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use diclofenac gel.

Important safety information:

Diclofenac gel may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use diclofenac gel with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

Diclofenac gel is for external use only. Do not get it in your eyes, nose, or mouth. If you get it in any of these areas, rinse at once with cool water.

Serious stomach ulcers or bleeding can occur with the use of diclofenac gel. Taking it in high doses or for a long time, smoking, or drinking alcohol increases the risk of these side effects. Taking diclofenac gel with food will NOT reduce the risk of these effects. Contact your doctor or emergency room at once if you develop severe stomach or back pain; black, tarry stools; vomit that looks like blood or coffee grounds; or unusual weight gain or swelling.

Do NOT use more than the recommended dose or use for longer than prescribed without checking with your doctor.

Diclofenac gel is an NSAID. Before you start any new medicine, check the label to see if it has an NSAID (eg, ibuprofen) in it too. If it does or if you are not sure, check with your doctor or pharmacist.

Do not take aspirin while you are using diclofenac gel unless your doctor tells you to.

Do not use sunscreens, lotions, insect repellants, or other topical medicines on the treated area.

Do not expose the treated area to the sun, sunlamps, or tanning booths.

Diclofenac gel may cause harm if it is swallowed. If you may have taken it by mouth, contact your poison control center or emergency room right away.

Lab tests, including kidney and liver function, blood electrolyte levels, complete blood cell counts, and blood pressure, may be performed while you use diclofenac gel. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use diclofenac gel with caution in the ELDERLY; they may be more sensitive to its effects, especially stomach bleeding and kidney problems.

Diclofenac gel should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.

PREGNANCY and BREAST-FEEDING: Diclofenac gel may cause harm to the fetus. Do not use it during the last 3 months of pregnancy. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using diclofenac gel while you are pregnant. It is not known if this medicine is found in breast milk after topical use. Do not breast-feed while taking diclofenac gel.

Possible side effects of diclofenac gel:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Mild irritation at the application site.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; trouble breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody or black, tarry stools; change in the amount of urine produced; chest pain; confusion; depression; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; mental or mood changes; numbness of an arm or leg; one-sided weakness; red, swollen, blistered, or peeling skin; ringing in the ears; seizures; severe headache or dizziness; severe or persistent irritation at the application site; severe or persistent stomach pain or nausea; severe vomiting or diarrhea; shortness of breath; sudden or unexplained weight gain; swelling of the hands, legs, or feet; unusual bruising or bleeding; symptoms of liver problems (eg, dark urine, pale stools, persistent loss of appetite, yellowing of the skin or eyes); unusual joint or muscle pain; unusual tiredness or weakness; vision or speech changes; vomit that looks like coffee grounds.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA .

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center. or emergency room immediately. Symptoms may include decreased urination; loss of consciousness; seizures; severe dizziness or drowsiness; severe nausea, vomiting, or stomach pain; slow or troubled breathing; tremor; unusual bleeding or bruising; vomit that looks like coffee grounds.

Proper storage of diclofenac gel:

Store diclofenac gel at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep diclofenac gel out of the reach of children and away from pets.

General information:

If you have any questions about diclofenac gel, please talk with your doctor, pharmacist, or other health care provider.

Diclofenac gel is to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take diclofenac gel or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about diclofenac gel. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to diclofenac gel. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using diclofenac gel.

Review Date: August 8, 2016

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

More about diclofenac topical

Depakene (Valproic Acid) Drug Information Side Effects And Drug Interactions - Prescribing Informati

SIDE EFFECTS

The following serious adverse reactions are described below and elsewhere in the labeling:

Hepatic failure [see WARNINGS AND PRECAUTIONS ]

Birth defects [see WARNINGS AND PRECAUTIONS ]

Decreased IQ following in utero exposure [see WARNINGS AND PRECAUTIONS ]

Pancreatitis [see WARNINGS AND PRECAUTIONS ]

Hyperammonemic encephalopathy [see WARNINGS AND PRECAUTIONS ]

Suicidal behavior and ideation [see WARNINGS AND PRECAUTIONS ]

Bleeding and other hematopoietic disorders [see WARNINGS AND PRECAUTIONS ]

Hypothermia [see WARNINGS AND PRECAUTIONS ]

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)/Multiorgan hypersensitivity reactions [see WARNINGS AND PRECAUTIONS ]

Somnolence in the elderly [see WARNINGS AND PRECAUTIONS ]

Because clinical studies are conducted under widely varying conditions, adverse reaction rates observed in the clinical studies of a drug cannot be directly compared to rates in the clinical studies of another drug and may not reflect the rates observed in practice.

Epilepsy

The data described in the following section were obtained using Depakote (divalproex sodium) tablets.

Based on a placebo-controlled trial of adjunctive therapy for treatment of complex partial seizures, Depakote was generally well tolerated with most adverse reactions rated as mild to moderate in severity. Intolerance was the primary reason for discontinuation in the Depakote?treated patients (6%), compared to 1% of placebo-treated patients.

Table 3 lists treatment-emergent adverse reactions which were reported by ≥ 5% of Depakote?treated patients and for which the incidence was greater than in the placebo group, in a placebo-controlled trial of adjunctive therapy for the treatment of complex partial seizures. Since patients were also treated with other antiepilepsy drugs, it is not possible, in most cases, to determine whether the following adverse reactions can be ascribed to Depakote alone, or the combination of Depakote and other antiepilepsy drugs.

Table 3: Adverse Reactions Reported by ≥ 5% of Patients Treated with Depakote During Placebo-Controlled Trial of Adjunctive Therapy for Complex Partial Seizures

Depakote (%) (n = 77)

Table 4 lists treatment-emergent adverse reactions which were reported by ≥ 5% of patients in the high dose Depakote group, and for which the incidence was greater than in the low dose group, in a controlled trial of Depakote monotherapy treatment of complex partial seizures. Since patients were being titrated off another antiepilepsy drug during the first portion of the trial, it is not possible, in many cases, to determine whether the following adverse reactions can be ascribed to Depakote alone, or the combination of Depakote and other antiepilepsy drugs.

Table 4: Adverse Reactions Reported by ≥ 5% of Patients in the High Dose Group in the Controlled Trial of Depakote Monotherapy for Complex Partial Seizures 1

High Dose (%) (n = 131)

Low Dose (%) (n = 134)

Body as a Whole

Skin and Appendages

1 Headache was the only adverse reaction that occurred in ≥ 5% of patients in the high dose group and at an equal or greater incidence in the low dose group.

The following additional adverse reactions were reported by greater than 1% but less than 5% of the 358 patients treated with Depakote in the controlled trials of complex partial seizures:

Hemic and Lymphatic System: Petechia.

Metabolic and Nutritional Disorders: SGOT increased, SGPT increased.

Skin and Appendages: Rash, pruritus. dry skin.

Mania

Although Depakene has not been evaluated for safety and efficacy in the treatment of manic episodes associated with bipolar disorder. the following adverse reactions not listed above were reported by 1% or more of patients from two placebo-controlled clinical trials of Depakote tablets.

Body as a Whole: Chills, neck pain. neck rigidity.

Skin and Appendages: Furunculosis, maculopapular rash, seborrhea .

Special Senses: Conjunctivitis. dry eyes, eye pain.

Migraine

Although Depakene has not been evaluated for safety and efficacy in the treatment of prophylaxis of migraine headaches, the following adverse reactions not listed above were reported by 1% or more of patients from two placebo-controlled clinical trials of Depakote tablets.

Body as a Whole: Face edema.

Digestive System: Dry mouth. stomatitis.

Post-Marketing Experience

The following adverse reactions have been identified during post approval use of Depakote. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Dermatologic: Hair texture changes, hair color changes, photosensitivity. erythema multiforme. toxic epidermal necrolysis, nail and nail bed disorders, and Stevens-Johnson syndrome .

Psychiatric: Emotional upset, psychosis. aggression, psychomotor hyperactivity, hostility, disturbance in attention, learning disorder, and behavioral deterioration.

Neurologic: There have been several reports of acute or subacute cognitive decline and behavioral changes (apathy or irritability) with cerebral pseudoatrophy on imaging associated with valproate therapy; both the cognitive/behavioral changes and cerebral pseudoatrophy reversed partially or fully after valproate discontinuation.

Musculoskeletal: Fractures, decreased bone mineral density, osteopenia. osteoporosis. and weakness.

Hematologic: Relative lymphocytosis. macrocytosis, leucopenia, anemia including macrocytic with or without folate deficiency, bone marrow suppression, pancytopenia. aplastic anemia. agranulocytosis. and acute intermittent porphyria.

Endocrine: Irregular menses, secondary amenorrhea. hyperandrogenism, hirsutism. elevated testosterone level, breast enlargement, galactorrhea. parotid gland swelling, polycystic ovary disease, decreased carnitine concentrations, hyponatremia. hyperglycinemia, and inappropriate ADH secretion.

There have been rare reports of Fanconi's syndrome occurring chiefly in children.

Metabolism and nutrition: Weight gain.

Reproductive: Aspermia, azoospermia. decreased sperm count, decreased spermatozoa motility, male infertility. and abnormal spermatozoa morphology.

Genitourinary: Enuresis and urinary tract infection.

Special Senses: Hearing loss.

Read the Depakene (valproic acid) Side Effects Center for a complete guide to possible side effects

DRUG INTERACTIONS

Effects Of Co-Administered Drugs On Valproate Clearance

Drugs that affect the level of expression of hepatic enzymes, particularly those that elevate levels of glucuronosyltransferases (such as ritonavir), may increase the clearance of valproate. For example, phenytoin, carbamazepine, and phenobarbital (or primidone) can double the clearance of valproate. Thus, patients on monotherapy will generally have longer half-lives and higher concentrations than patients receiving polytherapy with antiepilepsy drugs.

In contrast, drugs that are inhibitors of cytochrome P450 isozymes, e. g. antidepressants. may be expected to have little effect on valproate clearance because cytochrome P450 microsomal mediated oxidation is a relatively minor secondary metabolic pathway compared to glucuronidation and beta-oxidation.

Because of these changes in valproate clearance, monitoring of valproate and concomitant drug concentrations should be increased whenever enzyme inducing drugs are introduced or withdrawn.

The following list provides information about the potential for an influence of several commonly prescribed medications on valproate pharmacokinetics. The list is not exhaustive nor could it be, since new interactions are continuously being reported.

Drugs for which a potentially important interaction has been observed

Aspirin

A study involving the co-administration of aspirin at antipyretic doses (11 to 16 mg/kg) with valproate to pediatric patients (n = 6) revealed a decrease in protein binding and an inhibition of metabolism of valproate. Valproate free fraction was increased 4-fold in the presence of aspirin compared to valproate alone. The β-oxidation pathway consisting of 2-E-valproic acid, 3-OH?valproic acid, and 3-keto valproic acid was decreased from 25% of total metabolites excreted on valproate alone to 8.3% in the presence of aspirin. Caution should be observed if valproate and aspirin are to be co-administered.

Carbapenem Antibiotics

A clinically significant reduction in serum valproic acid concentration has been reported in patients receiving carbapenem antibiotics (for example, ertapenem, imipenem, meropenem; this is not a complete list) and may result in loss of seizure control. The mechanism of this interaction is not well understood. Serum valproic acid concentrations should be monitored frequently after initiating carbapenem therapy. Alternative antibacterial or anticonvulsant therapy should be considered if serum valproic acid concentrations drop significantly or seizure control deteriorates [see WARNINGS AND PRECAUTIONS ].

Cholestyramine

Cholestyramine, when concurrently administered with valproic acid, led to, on average, a 14% decrease in plasma levels of valproic acid in a study conducted in 6 healthy subjects administered Depakene (valproic acid) and cholestyramine. Delaying the administration of cholestyramine relative to valproic acid administration by 3 hours may lessen the interaction.

Felbamate

A study involving the co-administration of 1200 mg/day of felbamate with valproate to patients with epilepsy (n = 10) revealed an increase in mean valproate peak concentration by 35% (from 86 to 115 mcg/mL) compared to valproate alone. Increasing the felbamate dose to 2400 mg/day increased the mean valproate peak concentration to 133 mcg/mL (another 16% increase). A decrease in valproate dosage may be necessary when felbamate therapy is initiated.

Rifampin

A study involving the administration of a single dose of valproate (7 mg/kg) 36 hours after 5 nights of daily dosing with rifampin (600 mg) revealed a 40% increase in the oral clearance of valproate. Valproate dosage adjustment may be necessary when it is co-administered with rifampin.

Drugs For Which Either No Interaction Or A Likely Clinically Unimportant Interaction Has Been Observed

Antacids

A study involving the co-administration of valproate 500 mg with commonly administered antacids (Maalox, Trisogel, and Titralac -160 mEq doses) did not reveal any effect on the extent of absorption of valproate.

Chlorpromazine

A study involving the administration of 100 to 300 mg/day of chlorpromazine to schizophrenic patients already receiving valproate (200 mg BID) revealed a 15% increase in trough plasma levels of valproate.

Haloperidol

A study involving the administration of 6 to 10 mg/day of haloperidol to schizophrenic patients already receiving valproate (200 mg BID) revealed no significant changes in valproate trough plasma levels.

Cimetidine and Ranitidine

Cimetidine and ranitidine do not affect the clearance of valproate.

Effects Of Valproate On Other Drugs

Valproate has been found to be a weak inhibitor of some P450 isozymes, epoxide hydrase, and glucuronyltransferases.

The following list provides information about the potential for an influence of valproate co?administration on the pharmacokinetics or pharmacodynamics of several commonly prescribed medications. The list is not exhaustive, since new interactions are continuously being reported.

Drugs For Which A Potentially Important Valproate Interaction Has Been Observed

Amitriptyline/Nortriptyline

Administration of a single oral 50 mg dose of amitriptyline to 15 normal volunteers (10 males and 5 females) who received valproate (500 mg BID) resulted in a 21% decrease in plasma clearance of amitriptyline and a 34% decrease in the net clearance of nortriptyline. Rare postmarketing reports of concurrent use of valproate and amitriptyline resulting in an increased amitriptyline level have been received. Concurrent use of valproate and amitriptyline has rarely been associated with toxicity. Monitoring of amitriptyline levels should be considered for patients taking valproate concomitantly with amitriptyline. Consideration should be given to lowering the dose of amitriptyline/nortriptyline in the presence of valproate.

Carbamazepine/carbamazepine-10,11-Epoxide

Serum levels of carbamazepine (CBZ) decreased 17% while that of carbamazepine-10,11?epoxide (CBZ-E) increased by 45% upon co-administration of valproate and CBZ to epileptic patients.

Clonazepam

The concomitant use of valproate and clonazepam may induce absence status in patients with a history of absence type seizures.

Diazepam

Valproate displaces diazepam from its plasma albumin binding sites and inhibits its metabolism. Co-administration of valproate (1500 mg daily) increased the free fraction of diazepam (10 mg) by 90% in healthy volunteers (n = 6). Plasma clearance and volume of distribution for free diazepam were reduced by 25% and 20%, respectively, in the presence of valproate. The elimination half-life of diazepam remained unchanged upon addition of valproate.

Ethosuximide

Valproate inhibits the metabolism of ethosuximide. Administration of a single ethosuximide dose of 500 mg with valproate (800 to 1600 mg/day) to healthy volunteers (n = 6) was accompanied by a 25% increase in elimination half-life of ethosuximide and a 15% decrease in its total clearance as compared to ethosuximide alone. Patients receiving valproate and ethosuximide, especially along with other anticonvulsants, should be monitored for alterations in serum concentrations of both drugs.

Lamotrigine

In a steady-state study involving 10 healthy volunteers, the elimination half-life of lamotrigine increased from 26 to 70 hours with valproate co-administration (a 165% increase). The dose of lamotrigine should be reduced when co-administered with valproate. Serious skin reactions (such as Stevens-Johnson Syndrome and toxic epidermal necrolysis) have been reported with concomitant lamotrigine and valproate administration. See lamotrigine package insert for details on lamotrigine dosing with concomitant valproate administration.

Phenobarbital

Valproate was found to inhibit the metabolism of phenobarbital. Co-administration of valproate (250 mg BID for 14 days) with phenobarbital to normal subjects (n = 6) resulted in a 50% increase in half-life and a 30% decrease in plasma clearance of phenobarbital (60 mg single-dose). The fraction of phenobarbital dose excreted unchanged increased by 50% in presence of valproate.

There is evidence for severe CNS depression, with or without significant elevations of barbiturate or valproate serum concentrations. All patients receiving concomitant barbiturate therapy should be closely monitored for neurological toxicity. Serum barbiturate concentrations should be obtained, if possible, and the barbiturate dosage decreased, if appropriate.

Primidone, which is metabolized to a barbiturate, may be involved in a similar interaction with valproate.

Phenytoin

Valproate displaces phenytoin from its plasma albumin binding sites and inhibits its hepatic metabolism. Co-administration of valproate (400 mg TID) with phenytoin (250 mg) in normal volunteers (n = 7) was associated with a 60% increase in the free fraction of phenytoin. Total plasma clearance and apparent volume of distribution of phenytoin increased 30% in the presence of valproate. Both the clearance and apparent volume of distribution of free phenytoin were reduced by 25%.

In patients with epilepsy, there have been reports of breakthrough seizures occurring with the combination of valproate and phenytoin. The dosage of phenytoin should be adjusted as required by the clinical situation.

Rufinamide

Based on a population pharmacokinetic analysis, rufinamide clearance was decreased by valproate. Rufinamide concentrations were increased by < 16% to 70%, dependent on concentration of valproate (with the larger increases being seen in pediatric patients at high doses or concentrations of valproate). Patients stabilized on rufinamide before being prescribed valproate should begin valproate therapy at a low dose, and titrate to a clinically effective dose [see DOSAGE AND ADMINISTRATION ]. Similarly, patients on valproate should begin at a rufinamide dose lower than 10 mg/kg per day (pediatric patients) or 400 mg per day (adults).

Tolbutamide

From in vitro experiments, the unbound fraction of tolbutamide was increased from 20% to 50% when added to plasma samples taken from patients treated with valproate. The clinical relevance of this displacement is unknown.

Warfarin

In an in vitro study, valproate increased the unbound fraction of warfarin by up to 32.6%. The therapeutic relevance of this is unknown; however, coagulation tests should be monitored if valproate therapy is instituted in patients taking anticoagulants.

Zidovudine

In six patients who were seropositive for HIV. the clearance of zidovudine (100 mg q8h) was decreased by 38% after administration of valproate (250 or 500 mg q8h); the half-life of zidovudine was unaffected.

Drugs For Which Either No Interaction Or A Likely Clinically Unimportant Interaction Has Been Observed

Acetaminophen

Valproate had no effect on any of the pharmacokinetic parameters of acetaminophen when it was concurrently administered to three epileptic patients.

Clozapine

In psychotic patients (n = 11), no interaction was observed when valproate was co-administered with clozapine.

Lithium

Co-administration of valproate (500 mg BID) and lithium carbonate (300 mg TID) to normal male volunteers (n = 16) had no effect on the steady-state kinetics of lithium.

Lorazepam

Concomitant administration of valproate (500 mg BID) and lorazepam (1 mg BID) in normal male volunteers (n = 9) was accompanied by a 17% decrease in the plasma clearance of lorazepam.

Olanzapine

No dose adjustment for olanzapine is necessary when olanzapine is administered concomitantly with valproate. Co-administration of valproate (500 mg BID) and olanzapine (5 mg) to healthy adults (n=10) caused 15% reduction in Cmax and 35% reduction in AUC of olanzapine.

Oral Contraceptive Steroids

Administration of a single-dose of ethinyloestradiol (50 mcg)/levonorgestrel (250 mcg) to 6 women on valproate (200 mg BID) therapy for 2 months did not reveal any pharmacokinetic interaction.

Topiramate

Concomitant administration of valproate and topiramate has been associated with hyperammonemia with and without encephalopathy [see CONTRAINDICATIONS and WARNINGS AND PRECAUTIONS ]. Concomitant administration of topiramate with valproate has also been associated with hypothermia in patients who have tolerated either drug alone. It may be prudent to examine blood ammonia levels in patients in whom the onset of hypothermia has been reported [see WARNINGS AND PRECAUTIONS ].

This monograph has been modified to include the generic and brand name in many instances.

Last reviewed on RxList: 3/4/2016

Buy Cheap Other - Lioxam (Brand Name Risperdal) (Risperidone) Buy Other - Lioxam (Brand Name Risperd

Product Description Common use Risperidone belongs to the atypical antipsychotics. This medication is used to treat schizophrenia and bipolar disorder as well as irritability associated with autistic disorder in children and adolescents aged 5-16 years. It can be also applied in other cases.

Dosage and direction Take Risperdal by mouth with a glass of water, with or without food. Avoid cutting, crushing or chewing this medicine. Do not take the medicine more often than it is prescribed. Do not give up taking it except on the advice of your doctor. It may need time for the medicine to help. Consult your doctor concerning proper dose for you.

Precautions Before taking Risperidone tell your doctor or chemist if you are allergic to it; or if you have other allergies. Inform your doctor or chemist if you have Parkinson's disease, eye, liver or kidney problems, etc. Avoid drinking alcohol and smoking while being treated with this medication. Aged people can be more sensitive to side effects of the medicine. During the pregnancy this treatment should be used only when strongly necessary. As this medicament can be absorbed by skin, women who are pregnant or may become pregnant should not manipulate this medicine.

Contraindications Risperdal should not be used by pregnant/nursing women or children as well as by the patients having demonstrated a reaction of hypersensitivity to Risperidone.

Possible side effect The most common side effects are dry mouth, dizziness, irritability, sedation, insomnia, urinary retention, etc. A very serious allergic reaction rarely occurs. Many people using this medicine do not have serious side effects. Turn to your doctor or pharmacist for more details. In case you notice the effects not listed here, contact your doctor or pharmacist.

Drug interaction Tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use before using this medication. Risperidone can interact with: * droperidol; * sparfloxacin; * cisapride; * certain antibiotics; * medicines for high blood pressure; * medicines for seizures (convulsions) * medicines for sleep or sedation * medicines for mental depression, anxiety, etc. Turn to your doctor or pharmacist for more details.

Missed dose If you have missed your dose, take it as soon as you remember. If you see that it is near the time for the next dose, skip the missed dose and resume your usual dosing schedule. Do not take your dose twice.

Overdose If you think you have used too much of this medicine, seek emergency medical attention right away. The symptoms of overdose usually include chest pain, nausea, irregular heartbeat, and feeling light-headed or fainting.

Storage Store your medicines at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture. Do not store your drugs in the bathroom. Keep all drugs away from reach of children and pets.

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Evergreen Neuro Plus, Neuroplus

Evergreen Neuro Plus

Evergreen Neuro Plus

Neuro Plus consists of herbs that exert positive action in the treatment of neurodegenerative disorders, as confirmed by clinical and laboratory research. Neurodegenerative disorders are complex and pernicious diseases whose onset is insidious and is followed by progressive deterioration. The clinical manifestations are determined by the location and the seriousness of the disorder. The pathogenesis of neurodegenerative disorders is a mixture of deficient and excess conditions, represented by Kidney jing (essence) deficiency (a deficient condition), or blockage of the brain channel by blood stasis (an excess condition), or both. Prior to purchase of this product, consult an herbalist or acupuncturist in order to determine whether this herbal formula will be of benefit to you.

Alzheimer’s disease or dementia with decreased mental and cognitive functions

Parkinson’s disease with decreased mental and physical functions

Sequelae of stroke, such as poor speech, muscle paralysis, urinary and bowel incontinence, and constipation.

Disorders associated with degeneration of the nervous system and characterized by impaired mental and/or physical functions

A generalized decrease in mental functions, including forgetfulness, poor memory, difficulty concentrating, reduced comprehension, and possibly increased anxiety.

Decreased physical functions, such as slurred speech, muscle rigidity, poor balance, difficulty walking, involuntary salivation, frequent urination, constipation, difficulty swallowing, or visual problems.

Multiple sclerosis (MS)

WESTERN THERAPEUTIC ACTIONS:

Stimulates the nervous system to improve mental and physical functions

Increases blood circulation to the brain to improve mental functions

Increases blood circulation to the peripheral parts of the body to improve physical functions

CHINESE THERAPEUTIC ACTIONS:

Tonifies the Kidney yin, yang and jing (essence)

Regulates qi and blood circulation and removes blood stagnation

Opens the sensory orifices to promote awareness and alertness

Take 2 to 3 capsules three times daily on an empty stomach with warm water during the first week of herbal program. After the first week, increase the dosage to 4 capsules three times daily. Neuro Plus should be taken continuously for at least one to two months prior to making an evaluation and prognosis.

Ba Ji Tian (Radix Morindae Officinalis), Bai Zhi (Radix Angelicae Dahuricae), Bai Zhu (Rhizoma Atractylodis Macrocephalae), Bi Xie (Rhizoma Dioscoreae Hypoglaucae), Dan Shen (Radix Salviae Miltiorrhizae), Dong Chong Xia Cao (Cordyceps), Du Zhong (Cortex Eucommiae), Fu Ling (Poria), Gou Qi Zi (Fructus Lycii), Gui Ban (Plastrum Testudinis), He Shou Wu (Radix Polygoni Multiflori), Hong Hua (Flos Carthami), Huang Qi (Radix Astragali), Lu Jiao Shuang (Cornu Cervi Degelatinatium), Meng Chong (Tabanus), Qian Cheng Ta (Herba Lycopodii Serrati), Ren Shen (Radix Ginseng), San Qi (Radix Notoginseng), Shan Yao (Rhizoma Dioscoreae), Shan Zha (Fructus Crataegi), Shan Zhu Yu (Fructus Corni), Sheng Di Huang (Radix Rehmanniae), Shi Chang Pu (Rhizoma Acori), Shu Di Huang (Radix Rehmanniae Preparata), Shui Zhi (Hirudo), Tian Ma (Rhizoma Gastrodiae), Tu Si Zi (Semen Cuscutae), Wu Gong (Scolopendra), Xi Yang Shen (Radix Panacis Quinquefolii), Yi Zhi Ren (Fructus Alpiniae Oxyphyllae), Yin Guo Ye (Folium Ginkgo), Yuan Zhi (Radix Polygalae).

Stroke due to hemorrhage should not use this herbal formula until the condition stabilizes. Neuro Plus contains herbs that invigorate blood circulation, remove blood stasis, and prevent clotting. Patients taking anticoagulant or antiplatelet drugs should not take this formula without first consulting a licensed health care practitioner. Concurrent use of both herbs and drugs requires close supervision. This formula is contraindicated during pregnancy and nursing. A slight increase in blood pressure has been observed in approximately 3 to 5% of patients, due in part to the warm herbs in the formula. Should this happen, reduce the dosage of the herbs. Increase in blood pressure associated with the herbs is self-limiting.

Small frequent meals are recommended, instead of a few large meals. Avoid overeating, and stop when approximately 80% fullness is achieved. Weight loss is recommended, if obese. Cholesterol levels should be reduced if elevated. Encourage more "white meat" and less "red meat." Consume adequate amounts of vegetables for vitamins A, B1, B2, C and E. Avoid fried, smoked or barbecued foods. Stop smoking and avoid drinking alcohol. Avoid contact and exposure to aluminum, which may be found in antacids, cookware, aluminum foil, and certain foods. Drinking steam-distilled water has a chelating effect in the blood to remove unwanted aluminum from the body. Encourage a diet with a diverse source of all nutrients, including raw fruits, vegetables, whole grains, nuts, and seeds. B vitamins are important to maintain nerve health.

Exercise daily and maintain a positive, hopeful outlook toward the future. Regular workout and deep breathing exercises are excellent ways to oxygenate the blood and improve circulation to all parts of the body to facilitate recovery. When recuperating from a stroke, engage in regular and mild exercises, such as walking and swimming. However, make sure the activities are supervised as the risk of another accident (i. e. slip and fall) is high during the earlier period of recovery.

CLINICAL NOTES: Since neurodegenerative disorders are characterized by the chronic and deteriorating nature of the illness, herbal program is considered effective if there is: 1) improvement in the signs and symptoms, or 2) lack of deterioration or stabilization of the overall condition. It has been noted by many practitioners that Neuro Plus is effective in helping patients with multiple sclerosis. The general consensus is approximately one out of four patients will have a marked improvement, while the others showed only minimal changes. To prevent deterioration of cognitive function, take 1 to 2 capsule of Neuro Plus twice daily.

*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. If you are not familiar with these formulas or concepts please consult a licensed practitioner of Chinese herbal medicine and/or more in-depth reference materials.

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Zolpidem - Brand Name List From, Sumenan

Zolpidem

See also.

Disclaimer: The indications, uses and warnings for individual medications outside the USA are determined by local regulatory bodies in each country or region. The Drugs. com website is intended primarily for audiences in the United States and its territories. Indications, uses and warnings on Drugs. com patient information leaflets are derived from FDA product labels and may differ in countries outside the USA. Every effort has been made to ensure that the information provided on this page is accurate, up-to-date and complete, but no guarantee is made to that effect. Drugs. com does not endorse drugs, diagnose patients or recommend specific therapies. The information on this page is not a substitute for the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that a drug or drug combination is safe, effective or appropriate for any given patient. Drugs. com does not assume any responsibility for any aspect of healthcare administered with the aid of information provided here. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Always consult your doctor or healthcare specialist for medical advice.

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Situs Nama Obat Mefinter Kapsul, Mefinter

Mefinter Capsul 250 mg x 10, Mefinter, Informasi obat kali ini akan menjelaskan jenis obat nyeri otot, sakit telinga, rematik, yang diantaranya menjelaskan dosis obat, komposisi atau kandungan obat, manfaat atau kegunaan dan khasiat atau dalam bahasa medis indikasi, aturan pakai Mefinter, cara minum/makan atau cara menggunakannya, juga akan menerangkan efek samping atau kerugian, pantangan atau kontra indikasi serta bahayanya, over dosis atau keracunan, dan farmakologi serta meknisme kerja dan harga dari obat Mefinter, dan inilah penjelasannya:

Mefenamic acid/Asam mefenamat

Demam, sakit gigi, nyeri otot, sakit telinga, rematik, nyeri traumatik (terpukul, terbentur, teriris, dll) dan rasa sakit setelah operasi, bursitis (radang kandung sega), dismenore (nyeri pada saat haid).

Ulserasi peptik atau usus, penyakit peradangan usus besar, kerusakan hati atau ginjal.

Hamil, dehidrasi, asma, epilepsi.

Interaksi obat. antikoagulan oral.

Gangguan & perdarahan saluran pencernaan, ulkus peptikum, sakit kepala, mengantuk, pusing, gugup, gangguan penglihatan, kemerahan pada kulit, diskrasia darah, sakit ginjal.

INDEKS KEAMANAN PADA WANITA HAMIL

Penelitian pada hewan menunjukkan efek samping pada janin ( teratogenik atau embriosidal atau lainnya) dan belum ada penelitian yang terkendali pada wanita atau penelitian pada wanita dan hewan belum tersedia. Obat seharusnya diberikan bila hanya keuntungan potensial memberikan alasan terhadap bahaya potensial pada janin.

Kapsul 250 mg x 10 x 10 biji.

Deanna O Leary, Benalet

Deanna O'Leary

Deanna O’Leary was born in Corcoran, California but later moved to Little Rock, Arkansas. She returned to California in 1980 and has lived in Visalia since that time. She attended and graduated, with honors, from Fresno Pacific University. She began her career in health insurance with CIGNA Healthcare in 1991.

Deanna began her career processing medical claims and answering customer service calls. She continued to hold a variety of positions in the areas of project management, root cause analysis, efficiency training and capacity resource planning. Deanna is a certified Green Belt in Six Sigma business methodologies.

Deanna has been closely involved with the community over the years. Since 2000, she has been the Director of Music at the Tulare Missionary Baptist Church. She served on the Board of Directors and was Vice-President for “Imagine U’ – an interactive children’s museum for which she wrote the start up business plan as well as created the name for the museum itself. She also served on the board of the Gift of Life Foundation, an organ donation awareness group in central California and volunteered with the California Transplant Donor Network.

Deanna’s interests are varied but her passions include composing music and writing. She has published two books and a vocal compilation of original songs. She is married to her wonderful husband, Michael, who constantly supports and inspires her. When away from work, she enjoys golfing and spending time with family and friends.

Phone: (888) 886-7973

Fax: (559) 635-6527

Buy Surazem - Diltiazem - Online Without Prescriptions, Surazem

Cardizem (Surazem)

Cardizem is used for treating supraventricular tachycardia, a rhythm disturbance of the heart. It is also used for controlling heart rate response to other rhythm disturbances, specifically, atrial fibrillation and flutter. Cardizem is a calcium channel blocker. It works by slowing the electrical conduction in the heart, slowing heart rate, and/or normalizing heart rhythm.

Use Cardizem as directed by your doctor.

Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results from this medication.

Take Cardizem with a full glass of water. Swallow the pill whole. It is specially made to release medicine slowly in the body. Breaking or opening the pill would cause too much of the drug to be released at one time.

It is important to use Cardizem regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

Do not stop taking this medication without first talking to your doctor. If you stop taking Cardizem suddenly, your condition may become worse.

If you are being treated for high blood pressure, keep using this medication even if you feel fine.

If you miss a dose of Cardizem, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Cardizem.

Store Cardizem at room temperature away from moisture and heat. Keep Cardizem out of the reach of children and away from pets.

Active Ingredient: Diltiazem.

Do NOT use Cardizem if:

you are allergic to any ingredient in Cardizem

you have sick sinus syndrome or have second - or third-degree heart block and do not have a pacemaker, or very low blood pressure

you have atrial fibrillation or flutter and a pre-excitation syndrome (extra conduction pathway in the heart), such as Wolff-Parkinson-White syndrome (WPW) or Lown-Ganong-Levine syndrome (LGL)

you are receiving injectable beta-blockers (eg, metoprolol) or erythromycin.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Cardizem. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have heart failure or have had a recent heart attack with lung congestion, heart block, low blood pressure, a very slow heart rate, or abnormal heart rhythm

if you have kidney or liver disease.

Some medicines may interact with Cardizem. Tell your health care provider if you are taking any other medicines, especially any of the following:

Cimetidine or protease inhibitors (eg, indinavir) because they may increase the actions and side effects of Cardizem

Rifampin because it may decrease the effectiveness of Cardizem

Amiodarone, cisapride, digoxin, erythromycin, protease inhibitors (eg, indinavir), quinidine, tricyclic antidepressants (eg, desipramine), theophylline, or general anesthetics because toxic effects on the heart may occur

Benzodiazepines (eg, midazolam), beta-blockers (eg, metoprolol), buspirone, carbamazepine, cilostazol, corticosteroids (eg, prednisone), cyclosporine, HMG-CoA reductase inhibitors (eg, atorvastatin), macrolide immunomodulators (eg, tacrolimus) because the risk of their side effects, some potentially life-threatening, may be increased by Cardizem.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Cardizem may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Cardizem may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Cardizem with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Cardizem may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.

Cardizem may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Cardizem. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.

Tell your doctor or dentist that you take Cardizem before you receive any medical or dental care, emergency care, or surgery.

Lab tests, including electrocardiogram (ECG), heart rate, and blood pressure monitoring, may be performed while you use Cardizem. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Cardizem with caution in the elderly; they may be more sensitive to its effects.

Cardizem should not be used in children; safety and effectiveness in children have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Cardizem while you are pregnant. Cardizem is found in breast milk. Do not breastfeed while taking Cardizem.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Constipation; dizziness; facial flushing; headache; weakness.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); hallucinations; irregular heartbeat; swelling of the feet or hands; symptoms of liver problems (eg, yellowing of the skin or eyes, dark urine, pale stools); tender, bleeding, or swollen gums.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Customers who bought this product also bought

Cardizem (Surazem)

Cardizem is used for treating supraventricular tachycardia, a rhythm disturbance of the heart. It is also used for controlling heart rate response to other rhythm disturbances, specifically, atrial fibrillation and flutter. Cardizem is a calcium channel blocker. It works by slowing the electrical conduction in the heart, slowing heart rate, and/or normalizing heart rhythm.

Use Cardizem as directed by your doctor.

Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results from this medication.

Take Cardizem with a full glass of water. Swallow the pill whole. It is specially made to release medicine slowly in the body. Breaking or opening the pill would cause too much of the drug to be released at one time.

It is important to use Cardizem regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

Do not stop taking this medication without first talking to your doctor. If you stop taking Cardizem suddenly, your condition may become worse.

If you are being treated for high blood pressure, keep using this medication even if you feel fine.

If you miss a dose of Cardizem, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Cardizem.

Store Cardizem at room temperature away from moisture and heat. Keep Cardizem out of the reach of children and away from pets.

Active Ingredient: Diltiazem.

Do NOT use Cardizem if:

you are allergic to any ingredient in Cardizem

you have sick sinus syndrome or have second - or third-degree heart block and do not have a pacemaker, or very low blood pressure

you have atrial fibrillation or flutter and a pre-excitation syndrome (extra conduction pathway in the heart), such as Wolff-Parkinson-White syndrome (WPW) or Lown-Ganong-Levine syndrome (LGL)

you are receiving injectable beta-blockers (eg, metoprolol) or erythromycin.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Cardizem. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have heart failure or have had a recent heart attack with lung congestion, heart block, low blood pressure, a very slow heart rate, or abnormal heart rhythm

if you have kidney or liver disease.

Some medicines may interact with Cardizem. Tell your health care provider if you are taking any other medicines, especially any of the following:

Cimetidine or protease inhibitors (eg, indinavir) because they may increase the actions and side effects of Cardizem

Rifampin because it may decrease the effectiveness of Cardizem

Amiodarone, cisapride, digoxin, erythromycin, protease inhibitors (eg, indinavir), quinidine, tricyclic antidepressants (eg, desipramine), theophylline, or general anesthetics because toxic effects on the heart may occur

Benzodiazepines (eg, midazolam), beta-blockers (eg, metoprolol), buspirone, carbamazepine, cilostazol, corticosteroids (eg, prednisone), cyclosporine, HMG-CoA reductase inhibitors (eg, atorvastatin), macrolide immunomodulators (eg, tacrolimus) because the risk of their side effects, some potentially life-threatening, may be increased by Cardizem.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Cardizem may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Cardizem may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Cardizem with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Cardizem may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.

Cardizem may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Cardizem. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.

Tell your doctor or dentist that you take Cardizem before you receive any medical or dental care, emergency care, or surgery.

Lab tests, including electrocardiogram (ECG), heart rate, and blood pressure monitoring, may be performed while you use Cardizem. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Cardizem with caution in the elderly; they may be more sensitive to its effects.

Cardizem should not be used in children; safety and effectiveness in children have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Cardizem while you are pregnant. Cardizem is found in breast milk. Do not breastfeed while taking Cardizem.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Constipation; dizziness; facial flushing; headache; weakness.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); hallucinations; irregular heartbeat; swelling of the feet or hands; symptoms of liver problems (eg, yellowing of the skin or eyes, dark urine, pale stools); tender, bleeding, or swollen gums.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Customers who bought this product also bought

Benicar - Blood Pressure, Tensonit

Benicar is in a group of drugs called angiotensin II receptor antagonists. It is used to control high blood pressure in adults and children who are at least 6 years old, but it is not a cure. It is known that high blood pressure can damage your kidneys, and may lead to a stroke or heart failure so this drug helps to prevent these things. It is sometimes given together with other blood pressure medications.

Dosage and direction

Take this medication exactly as it was prescribed for you by your doctor. Take your doses at regular intervals, do not take the medication in larger amounts and, of course, do not take it for longer than it has been recommended by your doctor. Follow the directions on your prescription schedule. Your doctor may change your dose to make sure you get the best results from this medication. Take this medication by mouth with a full glass of water with or without food. You need to check your blood pressure on a regular basis, in this way you will be sure this medication is helping your condition. Do not miss any scheduled visits to your doctor. It may take up to 4 weeks for Benicar to control your blood pressure. Keep using this medication even if you feel fine because high blood pressure often has no symptoms. If you need to have any type of surgery, tell the surgeon ahead of time that you are using Benicar. You may need to stop using the medicine for a short time.

You should discuss with your doctor if you have any of these conditions: previous swelling of the tongue, face, or lips with difficulty breathing, difficulty swallowing, hoarseness, or tightening of the throat; heart failure, kidney disease or liver disease; if you are on a special diet, such as a low-salt diet; an unusual or allergic reaction to olmesartan, other medicines, foods, dyes, or preservatives; pregnant or trying to get pregnant and breast-feeding. Avoid drinking alcohol. It can lower your blood pressure and may increase some of the side effects of Benicar. Avoid becoming overheated or dehydrated during exercise and in hot weather. You have to follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

Contraindications You should not take Benicar if you are allergic to it. In case, you have any of these conditions, you may need a dose adjustment or some special tests for observing kidney disease, liver disease, congestive heart failure or if you are dehydrated. Do not use Benicar if you are pregnant and stop using Benicar and tell your doctor right away if you become pregnant. Benicar can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. Use effective birth control while taking Benicar. It is not known whether Benicar passes into breast milk or if it could harm a nursing baby. So you should not breast-feed while you are taking Benicar.

Possible side effects

Get emergency medical help if you have any of the signs of an allergic reaction (hives, difficulty breathing, swelling of your face, lips, tongue, or throat). In rare cases, Benicar can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you feel muscle pain, tenderness, or weakness especially if you also have fever, nausea or vomiting, and dark colored urine. Call your doctor at once if you have any other serious side effects, such as feeling like you might pass out, chest pain, urinating more or less than usual, or not at all, jaundice (yellowing of the skin or eyes) or dry mouth. Less serious side effects may include stomach pain, heartburn, diarrhea, joint pain, dizziness, spinning sensation, headache or dry cough. And this is not a complete list of side effects and others may occur.

Drug interactions Discuss with your doctor or health care professional all other medicines you are taking, including nonprescription medicines, nutritional supplements, or herbal products. Also you should tell your doctor or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. This things may affect the way your medicine works. Check with your doctor or health care professional before stopping or starting any of your medicines.

Missed dose Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include fast or slow heartbeat, feeling light-headed, or fainting.

Store Benicar at room temperature away from moisture and heat.

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Benicar is in a group of drugs called angiotensin II receptor antagonists. It is used to control high blood pressure in adults and children who are at least 6 years old, but it is not a cure. It is known that high blood pressure can damage your kidneys, and may lead to a stroke or heart failure so this drug helps to prevent these things. It is sometimes given together with other blood pressure medications.

Dosage and direction

Take this medication exactly as it was prescribed for you by your doctor. Take your doses at regular intervals, do not take the medication in larger amounts and, of course, do not take it for longer than it has been recommended by your doctor. Follow the directions on your prescription schedule. Your doctor may change your dose to make sure you get the best results from this medication. Take this medication by mouth with a full glass of water with or without food. You need to check your blood pressure on a regular basis, in this way you will be sure this medication is helping your condition. Do not miss any scheduled visits to your doctor. It may take up to 4 weeks for Benicar to control your blood pressure. Keep using this medication even if you feel fine because high blood pressure often has no symptoms. If you need to have any type of surgery, tell the surgeon ahead of time that you are using Benicar. You may need to stop using the medicine for a short time.

You should discuss with your doctor if you have any of these conditions: previous swelling of the tongue, face, or lips with difficulty breathing, difficulty swallowing, hoarseness, or tightening of the throat; heart failure, kidney disease or liver disease; if you are on a special diet, such as a low-salt diet; an unusual or allergic reaction to olmesartan, other medicines, foods, dyes, or preservatives; pregnant or trying to get pregnant and breast-feeding. Avoid drinking alcohol. It can lower your blood pressure and may increase some of the side effects of Benicar. Avoid becoming overheated or dehydrated during exercise and in hot weather. You have to follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

Contraindications You should not take Benicar if you are allergic to it. In case, you have any of these conditions, you may need a dose adjustment or some special tests for observing kidney disease, liver disease, congestive heart failure or if you are dehydrated. Do not use Benicar if you are pregnant and stop using Benicar and tell your doctor right away if you become pregnant. Benicar can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. Use effective birth control while taking Benicar. It is not known whether Benicar passes into breast milk or if it could harm a nursing baby. So you should not breast-feed while you are taking Benicar.

Possible side effects

Get emergency medical help if you have any of the signs of an allergic reaction (hives, difficulty breathing, swelling of your face, lips, tongue, or throat). In rare cases, Benicar can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you feel muscle pain, tenderness, or weakness especially if you also have fever, nausea or vomiting, and dark colored urine. Call your doctor at once if you have any other serious side effects, such as feeling like you might pass out, chest pain, urinating more or less than usual, or not at all, jaundice (yellowing of the skin or eyes) or dry mouth. Less serious side effects may include stomach pain, heartburn, diarrhea, joint pain, dizziness, spinning sensation, headache or dry cough. And this is not a complete list of side effects and others may occur.

Drug interactions Discuss with your doctor or health care professional all other medicines you are taking, including nonprescription medicines, nutritional supplements, or herbal products. Also you should tell your doctor or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. This things may affect the way your medicine works. Check with your doctor or health care professional before stopping or starting any of your medicines.

Missed dose Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include fast or slow heartbeat, feeling light-headed, or fainting.

Store Benicar at room temperature away from moisture and heat.

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Aristopharma Ltd, Ametil

Ametil

Prochlorperazine

Prochlorperazine is a potent phenothiazine antipsychotic, derivative of the piperazine group, now largely used as an antiemetic and to treat vertigo. The effects of this drug is apparent at all levels of the nervous system. It antagonizes postsynaptic dopamine D1 receptor that activates adenylate cyclase and synthesis of cAMP. It also antagonizes D2 receptors which do not activate adenylate cyclase. It also inhinits pre - and post synaptic adrenoreceptors and also acetylcholine, serotonin and histamine receptors. These various pharacodynamic actions combine to produce not only antipsychotic, but also central antiemetic and sedative effects.

Product Details

Presentation

Ametil Tablet: Each tablet contains Prochlorperazine Maleate BP 5 mg.

Pharmacology

Prochlorperazine is a potent phenothiazine antipsychotic, derivative of the piperazine group, now largely used as an antiemetic and to treat vertigo. The effects of this drug is apparent at all levels of the nervous system. It antagonizes postsynaptic dopamine D1 receptor that activates adenylate cyclase and synthesis of cAMP. It also antagonizes D2 receptors which do not activate adenylate cyclase. It also inhinits pre - and post synaptic adrenoreceptors and also acetylcholine, serotonin and histamine receptors. These various pharacodynamic actions combine to produce not only antipsychotic, but also central antiemetic and sedative effects.

Indication

Severe nausea, vomiting, vertigo and other psychotic disorders.

Dosage & Administration

Nausea & vomiting: 5 to 10 mg two to three times daily. 20 mg at starting & 10 mg two hours later or as directed by physicians. Vertigo and Meniere's syndrome: 5 mg thrice and max. 30 mg daily. After several weeks dosage may be reduced to 5-10 mg daily or as directed by physicians. Anxiety: 15-20 mg daily in divided doses initially but this may be increased to a max. 40 mg daily or as directed by physicians. Schizophrenia and other psychotic disorders: 75 to 100 mg daily, but patients; response varies widely in response and the dosage schedule for Ametil is initially 12.5 mg twice daily for 7 days, the dose per day may be increased at four to seven days intervals until a satisfactory response is obtained. After some weeks, the effective dosage can be reduced. Children: For the treatment of nausea and vomiting, the dose is 0.25 mg/kg body weight two to three times a day or as directed.

Contraindications

Hypersensitivity, jaundice, CNS depression and in cardiovascular diseases.

Side effects

Drowsiness, dryness of mouth, mild skin rashes, neuromuscular effects, blurred vission, convulsion, difficulty in breathing may occur rarely

Use in special groups

Use in pregnancy: Safety of this drug in pregnancy has not been established. Pregnant mothers should use this drug only in case of severe nausea & vomiting with recognition of the potential risk. Use in lactation: Prochlorperazine releases in breast milk. So lactating mothers should not use this drug.

Packing

Ametil Tablet: Each box contains 500's tablets in strip pack.

Atacand (Candesartan Cilexetil) Side Effects, Interactions, Warning, Dosage & Uses, Hytacand

When pregnancy is detected, discontinue ATACAND as soon as possible [see WARNINGS AND PRECAUTIONS ].

Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus [see WARNINGS AND PRECAUTIONS ].

DRUG DESCRIPTION

ATACAND (candesartan cilexetil), a prodrug. is hydrolyzed to candesartan during absorption from the gastrointestinal tract. Candesartan is a selective AT1 subtype angiotensin II receptor antagonist.

Candesartan cilexetil, a nonpeptide, is chemically described as (±)-1-Hydroxyethyl 2-ethoxy-1-[p-(o-1H-tetrazol-5ylphenyl)benzyl]-7-benzimidazolecarboxylate, cyclohexyl carbonate (ester).

Its empirical formula is C 33 H 34 N 6 O 6 . and its structural formula is:

Candesartan cilexetil is a white to off-white powder with a molecular weight of 610.67. It is practically insoluble in water and sparingly soluble in methanol. Candesartan cilexetil is a racemic mixture containing one chiral center at the cyclohexyloxycarbonyloxy ethyl ester group. Following oral administration, candesartan cilexetil undergoes hydrolysis at the ester link to form the active drug, candesartan, which is achiral.

ATACAND is available for oral use as tablets containing either 4 mg, 8 mg, 16 mg, or 32 mg of candesartan cilexetil and the following inactive ingredients: hydroxypropyl cellulose, polyethylene glycol, lactose, corn starch, carboxymethylcellulose calcium, and magnesium stearate. Ferric oxide (reddish brown) is added to the 8-mg, 16-mg, and 32-mg tablets as a colorant.

What are the possible side effects of candesartan (Atacand)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

In rare cases, candesartan can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.

Call your doctor at once if you have:

a light-headed feeling, like you might pass out;

chest.

What are the precautions when taking candesartan cilexetil (Atacand)?

Before taking candesartan, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, high blood levels of potassium in the blood (hyperkalemia), loss of too much body water and/or minerals (dehydration).

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

Too much sweating, diarrhea, or vomiting may cause you to feel lightheaded. Report prolonged.

Last reviewed on RxList: 2/24/2016 This monograph has been modified to include the generic and brand name in many instances.

Calcipar Sa, Luxembourg - Credit Report, Calcifar

Calcipar SA

Other professional, scientific and technical activities (NACE code: 74)

Last modified: 12.03.2016

Calcipar SA has its registered office in Luxembourg, Luxembourg. Its current status is listed as active. The company is registered at the Registre de commerce et des societes at the local court of Luxembourg with the legal form of Societe Anonyme (number B 22.611). 6 directors currently run the company: 6 members of the board of administration. The company has one location. The company report was last updated on Mar 12, 2016.

Kaufen Ratiogel Online, Ratiogel

Indocin wird zur Behandlung von mittelschwerer bis schwerer rheumatoider Arthritis, Osteoarthritis und Spondylitis ankylosans eingesetzt. Es wird verwendet, um Gicht oder bestimmte Typen von Bursitis und Tendinitis zu behandeln. Es kann auch fur andere Bedingungen als die von Ihrem Arzt bestimmt werden. Indocin ist ein NSAR. NSAIDs Behandlung der Symptome von Schmerzen und Entzundungen. Sie nicht die Krankheit, die diese Symptome verursacht.

Verwenden Sie Indocin, wie von Ihrem Arzt! Uberprufen Sie das Etikett auf der Medizin fur die exakte Dosierung.

Nehmen Sie Indocin durch den Mund mit Essen. Dies kann nicht das Risiko von Magen - oder Darmprobleme (zum Beispiel Blutungen, Geschwure). Sprechen Sie mit Ihrem Arzt, wenn Sie anhaltende Magenverstimmung haben.

Nehmen Sie Indocin mit einem vollen Glas Wasser (8 oz / 240 ml), wie von Ihrem Arzt verordnet wurde.

Wenn Sie vermissen ein Dosis von Indocin und Sie nehmen sie regelma?ig, bringen Sie es so bald wie moglich. Wenn es fast Zeit fur Ihre nachste Dosis ist, uberspringen Sie die vergessene Dosis. Gehen Sie zuruck zu Ihrem regelma?igen Dosierungsschema. Nehmen Sie nicht 2 Dosen auf einmal.

Fragen Sie Ihren Arzt Fragen konnen Sie sich daruber, wie Indocin zu nutzen.

Shop Indocin bei Raumtemperatur zwischen 68 und 77 Grad Fahrenheit (20 und 25 Grad C). Getrennt von Hitze, Feuchtigkeit undlicht. Halten Sie Indocin nicht in die Hande von Kindern

Verwenden Sie keine Diclofenac, wenn:

Sie sind allergisch gegen jegliche Zutaten in Diclofenac oder Rinder (Kuh) Protein sind

Sie eine schwere allergische Reaktion (zB schweren Hautausschlag, Nesselsucht, Atembeschwerden, Wucherungen in der Nase, Schwindel) auf Aspirin oder ein NSAR haben (zB Ibuprofen, Celecoxib)

Sie vor kurzem oder werden mit Bypass-Herzoperation

schweren Nierenproblemen mussen Sie

Sie sind in der letzten 3 Monate der Schwangerschaft.

Kontaktieren Sie Ihren Arzt oder Arzt sofort, wenn dies auf Sie zutrifft.

Einige medizinische Bedingungen konnen mit Diclofenac zu interagieren. Informieren Sie Ihren Arzt oder Apotheker, wenn Sie irgendwelche medizinischen Bedingungen haben, vor allem, wenn einer der folgenden Punkte auf Sie zutrifft:

Wenn Sie schwanger sind, zu planen, schwanger zu werden oder stillen

Wenn Sie verschreibungspflichtige oder nicht verschreibungspflichtige Arzneimittel, pflanzliche Zubereitung oder Nahrungserganzungsmittel werden

Wenn Sie Allergien gegen Medikamente, Nahrungsmittel oder andere Substanzen haben

Wenn Sie eine Geschichte von Nieren - oder Leberproblemen, Diabetes oder Magen - oder Darmprobleme (zum Beispiel Blutungen, Perforationen, Ulzera)

Wenn Sie eine Geschichte von Schwellung oder Flussigkeitsansammlungen, Asthma, Wucherungen in der Nase (Nasenpolypen) oder Mund Entzundung haben

Wenn Sie hohen Blutdruck, Blutkrankheiten (zB Porphyrie), Blutungen oder Gerinnungsprobleme, Herzbeschwerden (zB Herzinsuffizienz) oder Blutgefa?krankheit haben, oder wenn Sie fur eine dieser Krankheiten

Wenn Sie schlechte Gesundheit, Dehydrierung oder niedrige Flussigkeitsvolumen oder Blut-Natrium niedrigen Niveau haben, rauchen Sie, Alkohol trinken oder haben eine Geschichte von Alkoholmissbrauch

Wenn Sie Einnahme eines Antibiotikums oder eine Anti-Anfall Medikament nehmen. Die Gefahr des Leberprobleme konnen mit einigen dieser Medikamente erhoht werden.

Einige Arzneimittel konnen mit Diclofenac zu interagieren. Informieren Sie Ihren Arzt, wenn Sie andere Arzneimittel, vor allem einer der folgenden:

Antikoagulantien (zB Warfarin), Aspirin, Clopidogrel, Kortikosteroide (zum Beispiel Prednison), Heparin und andere Blutverdunner (zB Dalteparin) oder selektive Serotonin-Wiederaufnahmehemmer (SSRI) (zB Fluoxetin), weil das Risiko von Magen Blutungen kann erhoht werden,

Acetaminophen, weil das Risiko von Leberproblemen erhoht werden

Probenecid, weil es das Risiko von Diclofenac zu Nebenwirkungen erhohen

Cyclosporin, Lithium, Metformin, Methotrexat, orale NSAIDs (zB, Ibuprofen) oder Chinolone (zB Ciprofloxacin), weil das Risiko von ihren Nebenwirkungen kann durch Diclofenac erhoht werden

Angiotensin-Converting-Enzym (ACE) - Hemmer (zB Enalapril) oder Diuretika (zB Furosemid, Hydrochlorothiazid), weil ihre Wirksamkeit von Diclofenac verringert werden.

Dies kann nicht eine vollstandige Liste aller Interaktionen, die auftreten konnen. Fragen Sie Ihren Arzt, wenn Diclofenac kann mit anderen Arzneimitteln, die Sie treffen. Prufen Sie mit Ihrem Arzt, bevor Sie starten, stoppen, oder andern Sie die Dosis einer Medizin.

Wichtige Sicherheitshinweise:

Diclofenac kann zu Schwindel oder Mudigkeit. Diese Auswirkungen konnen noch schlimmer, wenn Sie es mit Alkohol oder bestimmte Medikamente. Verwenden Sie Diclofenac mit Vorsicht. Nicht Auto fahren oder andere, moglicherweise unsichere Aufgaben, bis Sie wissen, wie Sie darauf reagieren.

Serious Magengeschwure oder Blutungen konnen mit dem Einsatz von Diclofenac auf. Taking it in hohen Dosen fur eine lange Zeit, Rauchen oder Alkoholkonsum erhoht das Risiko dieser Nebenwirkungen. Unter Diclofenac mit Essen wird nicht verringern das Risiko dieser Nebenwirkungen. Wenn Sie schwere Magen - oder Ruckenschmerzen; schwarzer, zaher Stuhl; Erbrochenes, das wie Blut oder Kaffeesatz aussieht; oder ungewohnliche Gewichtszunahme oder Schwellungen, fragen Sie Ihren Arzt oder Notaufnahme sofort.

Nehmen Sie nicht mehr als die empfohlene Dosis oder verwenden Sie fur langer als vorgeschrieben, ohne mit Ihrem Arzt.

Diclofenac ist ein NSAID. Bevor Sie beginnen eine neue Medizin, uberprufen Sie das Etikett zu sehen, ob es ein NSAR (zB Ibuprofen) in das auch. Wenn es nicht, oder wenn Sie nicht sicher sind, fragen Sie Ihren Arzt oder Apotheker.

Nehmen Sie nicht Aspirin, wahrend Sie mit Diclofenac es sei denn, Ihr Arzt sagt Ihnen zu.

Fragen Sie Ihren Arzt oder Apotheker, bevor Sie nehmen Paracetamol wahrend der Einnahme von Diclofenac sind. Die Gefahr des Leberproblemen erhoht werden.

zwischen verschiedenen Formen von Diclofenac (zB magensaftresistenten Tabletten mit sofortiger Freisetzung Tabletten, Kapseln) Schalten Sie nicht, wenn Ihr Arzt Ihnen dies sagt. Sie konnen nicht die gleiche Menge der Medizin, um Ihren Korper.

Labortests, einschlie?lich der Nierenfunktion, Leberfunktion, Blutelektrolythaushalt, Blutbild und Blutdruck, kann durchgefuhrt werden, wahrend Sie Diclofenac nutzen. Diese Tests konnen verwendet werden, um Ihren Zustand zu uberprufen oder auf Nebenwirkungen zu werden. Achten Sie darauf, alle Arzt-und Labor-Terminen.

Verwenden Sie Diclofenac mit Vorsicht bei alteren Menschen; sie moglicherweise empfindlicher auf deren Auswirkungen, insbesondere Magenblutungen und Nierenproblemen.

Diclofenac sollte mit au?erster Vorsicht bei Kindern angewendet werden; Sicherheit und Wirksamkeit bei Kindern wurden nicht bestatigt.

Schwangerschaft und Stillzeit: Diclofenac kann zu Schadigungen des Fotus. Wahrend der letzten 3 Monate der Schwangerschaft Verwenden Sie es nicht. Wenn Sie glauben, schwanger zu sein, fragen Sie Ihren Arzt. Sie mussen die Vorteile und Risiken der Verwendung von Diclofenac, wahrend Sie schwanger sind. Es ist nicht bekannt, ob Diclofenac in der Muttermilch gefunden. Wahrend der Einnahme von Diclofenac Stillen nicht.

Alle Arzneimittel konnen Nebenwirkungen haben, die aber viele Menschen haben keine oder nur geringfugige, Nebenwirkungen.

Uberprufen Sie mit Ihrem Arzt, wenn dieser am haufigsten auftretenden Nebenwirkungen fortbestehen oder storend empfunden werden:

Verstopfung; Diarrhoe; Benommenheit; Schlafrigkeit; Kopfschmerz; milde Bauchschmerzen oder Sodbrennen; Ubelkeit; Erbrechen.

Arztlich behandeln lassen, sofort, wenn dieser schwere Nebenwirkungen auftreten:

Schwere allergische Reaktionen (Hautausschlag, Nesselsucht, Juckreiz, Atembeschwerden, Engegefuhl in der Brust, Schwellungen im Mund-, Gesichts-, Lippen oder Zunge); blutig oder schwarz, Teerstuhle; Anderung in der Menge des Urins produziert; Brustschmerz; Verwirrung; Depression; Ohnmacht; schneller oder unregelma?iger Herzschlag; Fieber, Schuttelfrost, oder anhaltende Halsschmerzen; geistige oder Stimmungsschwankungen; Taubheit in einem Arm oder Bein; einseitige Schwache; persistent grippeahnlichen Symptomen; rot, geschwollen, Blasen, oder Schalen der Haut; Klingeln in den Ohren; Krampfanfalle; starke Kopfschmerzen oder Schwindel; schweren oder anhaltenden Bauchschmerzen oder Ubelkeit; starkem Erbrechen oder Durchfall; Kurzatmigkeit; plotzlicher oder unerklarliche Gewichtszunahme; Schwellung der Hande, Beine oder Fu?e; Symptome von Leber-Probleme (zB, dunkler Urin, heller Stuhl, anhaltende Appetitlosigkeit, Gelbfarbung der Haut oder Augen); ungewohnliche Blutergusse oder Blutungen; ungewohnliche Gelenk - oder Muskelschmerzen; ungewohnliche Mudigkeit oder Schwache; Vision oder Anderungen Rede; Erbrochenes, das wie Kaffeesatz aussieht.

Dies ist keine vollstandige Liste aller Nebenwirkungen, die auftreten konnen. Wenn Sie Fragen zu Nebenwirkungen haben, kontaktieren Sie Ihren Arzt.

Comprar Avandaglim (Amaryl) Sin Receta, Avandaglim

compra Avandaglim (Amaryl) en linea sin receta

Avandaglim (Amaryl) Explicacion

Avandaglim pueden ser la medicina de alta calidad, que se consume en la reparacion de la diabetes mellitus tipo 2.

El futuro del tratamiento ideal es en realidad luchan hacia la diabetes mellitus tipo 2.

Avandaglim tambien puede ser referido como glimepirida, Diapride, Amyline, Euglim.

Avandaglim esta realmente llevando a cabo a traves de la revitalizacion del pancreas real para crear mas insulina. Realmente es sulfonilureas.

titulo general asociada con Avandaglim es en realidad glimepirida.

Marca asociada con Avandaglim Avandaglim es en realidad.

Avandaglim (Amaryl) Dosis

Avandaglim viene en:

1mg Baja Dosis material de friccion

material de friccion dosis regular 2mg

4 mg Mejora Dosis material de friccion

Obtener pildoras Avandaglim por via oral junto con la hora del desayuno, asi como primer gran cena a traves del dia.

Por lo general, no moler o incluso masticar esto.

Obtener Avandaglim simultaneamente todos los dias junto con el agua potable.

Si usted desea lograr mejores resultados por lo general no dejar de usar Avandaglim, de repente.

Avandaglim (Amaryl) Careciendo asocia con dosis

Por lo general, no reciben doble dosis. En caso de que salte la dosis que necesita para llevar una vez se tiene en cuenta en lo que respecta a su deficiente. Cuando es hora de la dosis que necesita para llevar a cabo su propia rutina de dosificacion normal.

Avandaglim (Amaryl)

En el caso de que una sobredosis de Avandaglim y que tambien se evita gran usted necesita comprobar hacia fuera su medico o incluso el medico de inmediato.

Avandaglim (Amaryl) Espacio de almacenamiento

Tienda en temperaturas por debajo de los treinta niveles espaciales D (86 niveles F) de humedad, asi como la temperatura. Fortalecer cualquier tipo de medicamento sin tocar a partir del dia de vencimiento. Mantener desde el lograr de los ninos.

Avandaglim (Amaryl) Efectos negativos

Avandaglim ofrece los efectos negativos. El mas tipico tienden a ser:

un poco de material de friccion debilidad

material de friccion vision borrosa

interrupcion del material de friccion de estomago

Material vientre molestias friccion

material de friccion pis oscuro

material de friccion mareo

poros mejoradas y sensibilizacion de la piel con el fin de Sunshine material de friccion

material de friccion migrana

vomitando material de friccion

efectos negativos Mucho menos tipicos y graves en todo el uso de Avandaglim:

reaccion alergica material de friccion area de la boca respuestas (urticaria, inhalando y exhalando, cuestiones de alergia, asi como la erupcion) material de friccion

secado

material de friccion fatiga

friccion disnea materiales

para respirar que los olores material de friccion afrutado

Material deseo friccion severa

vomitando material de friccion

antojos de alimentos severas material de friccion

problemas con pis material de friccion

Los efectos negativos son indicaciones se basan en medicamentos que podrian estar utilizando pero, ademas, se basan en su condicion de bienestar y otros aspectos.

Avandaglim (Amaryl) Contraindicaciones

Por lo general no reciben Avandaglim si usted es sensible a fin de elementos Avandaglim.

Por lo general no reciben Avandaglim si usted esta esperando otra manera tiene la intencion de tener un hijo, si no que realmente eres una mama medica. Avandaglim puede cerdo a su hijo.

Puede ser danino para hacer uso de Avandaglim en caso de que se ven afectados por y tienen una breve historia asociada con problemas del corazon.

Evite las bebidas alcoholicas.

Por lo general, no dejar de usar Avandaglim, de repente.

Avandaglim (Amaryl) Preguntas comunes

Reina: Es importante informacion Avandaglim debo entender?

El: Avandaglim puede ser la medicina de alta calidad, que se consume en la reparacion de la diabetes mellitus tipo 2. Obtener Avandaglim con cuidado en caso de que se ven afectados por y tienen una breve historia asociada con enfermedades cardiovasculares. Por lo general, no dejar de fumar tomar ventaja de este medicamento de repente. Bare este medicamento de ninos y no hacer esto algunas otras personas. Por lo general no reciben Avandaglim en caso de reaccion alergica a este medicamento oa sus componentes. Realmente es inaceptable considerar Avandaglim si usted esta esperando otra manera tiene la intencion de tener un hijo, si no que realmente eres una mama medica. Es aconsejable evitar las bebidas alcoholicas si usted desea lograr mejor outcomes. A

Queen: ?Cuales son exactamente los efectos negativos Avandaglim?

El: Avandaglim ofrece los tipicos efectos negativos, por ejemplo: alguna debilidad, vision borrosa, alteracion del estomago. malestar vientre, pis oscuro, mareo, poros y mejora de la concienciacion de la piel con el fin de la luz del sol, la migrana, vomitar. Sin embargo en la situacion que se asocia con el rechazo asociado con componentes Avandaglim que son capaces de encontrar efectos negativos mas graves: asociado con la respuesta de reaccion alergica (urticaria, problemas con la inhalacion y la exhalacion, la alergia, la inflamacion, cierre), secos area de la boca, fatiga, disnea. la respiracion que los olores a fruta, deseo severa, vomitos, antojos de alimentos graves, problemas con peeing. A

Queen: ?Cuales son exactamente general, asi como las marcas asociadas con Avandaglim?

El: Marca asociada con Avandaglim Avandaglim es en realidad. Titulo general asociada con Avandaglim es en realidad Glimepiride. A

Reina: ?Se puede realmente consumir alcohol?

El: Por supuesto que no, lo que realmente es inaceptable aprecian alcoholica beverages. A

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Female Stormtrooper Costumes Are Just As Awesome As They Sound, Fem7

This Man Created Awesome Female Stormtrooper Costumes to Fill a 'Void in Women's Cosplay Armor'

By Ana Calderone

03/03/2016 AT 03:40 PM EST

As a huge Star Wars fan and designer of cosplay armor for over 10 years, Kevin Weir knows the ins and out of the costuming world. So when he noticed a lack of legitimate female stormtrooper armor, he set out to create the FEM7 kit.

"I felt there was a void in women's cosplay armor that characterized the female form while giving a sense of power when wearing it," Weir, 40, tells PEOPLE. "I wanted to design a look which covered the body and was pleasing to look at. The armor also needed to appear it served a purpose."

It took the Los Angeles native – who sells his creations on his website Imperial Surplus – about seven weeks of designing, collaborating with friends, and getting input from the women in his life, including his wife Brooke, to complete the project.

"Having good friends who all cosplay has been fantastic to discuss ideas with," he says. "Their excitement, feedback and involvement encourage me to do my best work."

Here's Your First Look at Star Wars: Rogue One

Much of his inspiration for FEM7 came from studying armor designs from past Star Wars movies, like Star Wars: The Clone Wars . as well as the "new look" of the First Order stormtroopers like Captain Phasma (played by Gwendoline Christie ) in the latest, Star Wars: The Force Awakens .

"I wanted to bring that all together, and have something that was smooth and organic-looking with intertwined hard geometric shapes," he says. "Most of all, I wanted something that could appear likely to fit into the Star Wars universe."

A highlight for the Memphis College of Art graduate was debuting his armor on women from the Star Wars costuming club 501st Legion at the Long Beach Comic Expo last month.

"It was a bit surreal for me to finally see an idea in my head take shape," he says. "Seeing them walking around and being asked for pictures was a wonderful feeling and a great accomplishment. I am so grateful I can share and use my talents and passion for the art I create to help bring people together in their love for Star Wars and costuming."

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