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Anacin (Bivinadol extra)

Anacin is used for treating pain including, headache, muscle aches, sprains, tooth extraction and toothache, menstrual cramps, arthritis and rheumatism, and pain and fever of the common cold. It may also be used for other conditions as determined by your doctor.

Use Anacin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take Anacin by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation. Taking it with food may not decrease the risk of stomach or bowel problems (eg, bleeding, ulcers) that may occur while taking Anacin.

Take Anacin with a full glass of water (8 oz/240 mL). Do not lie down for 30 minutes after taking Anacin.

Use Anacin exactly as directed on the package, unless instructed differently by your doctor. If you are taking Anacin without a prescription, follow any warnings and precautions on the label.

If you miss a dose of Anacin and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Anacin.

Store Anacin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Anacin out of the reach of children and away from pets.

Anacin may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Anacin with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

Avoid large amounts of food or drink that have caffeine (eg, coffee, tea, cocoa, cola, chocolate). This includes any medicines that contain caffeine.

Anacin has aspirin in it. Before you start any new medicine, check the label to see if it has aspirin in it too. If it does or if you are not sure, check with your doctor or pharmacist.

Talk to your doctor before you take Anacin or other pain relievers/fever reducers if you drink more than 3 drinks with alcohol per day. Serious stomach ulcers or bleeding can occur with the use of Anacin. Taking it in high doses or for a long time, smoking, or drinking alcohol increases the risk of these side effects. Taking Anacin with food will NOT reduce the risk of these effects. Contact your doctor or emergency room at once if you develop severe stomach or back pain; black, tarry stools; vomit that looks like blood or coffee grounds; or unusual weight gain or swelling.

Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor. Taking more than the recommended dose or taking Anacin regularly may be habit-forming.

Anacin may reduce the number of clot-forming cells (platelets) in your blood. To prevent bleeding, avoid situations in which bruising or injury may occur. Report any unusual bleeding, bruising, blood in stools, or dark, tarry stools to your doctor.

Aspirin has been linked to a serious illness called Reye syndrome. Do not give Anacin to a child or teenager who has the flu, chickenpox, or a viral infection. Contact your doctor with any questions or concerns.

Diabetes patients - Anacin may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

If Anacin has a strong vinegar-like smell upon opening, do not use. It means the medicine is breaking down. Throw the bottle away safely and out of the reach of children; contact your pharmacist and replace.

Tell your doctor or dentist that you take Anacin before you receive any medical or dental care, emergency care, or surgery.

Do not take Anacin for at least 7 days after any surgery unless directed by your health care provider.

Do not take Anacin for more than 10 days for pain or for more than 3 days for fever unless directed to do so by your health care provider.

Different brands of Anacin may have different dosing instructions for CHILDREN. Follow the dosing instructions on the package labeling. If your doctor has given you instructions, follow those. If you are unsure of the dose to give a child, check with your doctor or pharmacist.

Do NOT use Anacin if:

you are allergic to any ingredient in Anacin

you are a child or teenager with influenza (flu) or chickenpox

you have bleeding problems such as hemophilia, von Willebrand disease, or low blood platelets, or you have active severe bleeding

you have had a severe allergic reaction (eg, severe rash, hives, breathing difficulties, dizziness) to aspirin, tartrazine, or a nonsteroidal anti-inflammatory drug (NSAID) (eg, ibuprofen, naproxen, celecoxib)

you are taking anticoagulants (eg, heparin, warfarin) or methotrexate

Before using Anacin:

Some medical conditions may interact with Anacin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have alcoholism or if you consume 3 or more alcohol-containing drinks every day

if you have asthma, bleeding or clotting problems, growths in the nose (nasal polyps), kidney or liver problems, stomach or intestinal problems (eg, ulcer, inflammation), heart problems, heartburn, upset stomach, stomach pain, hives, influenza (flu) or chickenpox, or vitamin K deficiency

if you have anxiety, trouble sleeping, or heart problems

if you are a child with a stroke, a weakened blood vessel (cerebral aneurysm) or bleeding in the brain, rheumatic disease (eg, rheumatoid arthritis), or Kawasaki syndrome (a rare inflammation causing heart problems in children)

Some MEDICINES MAY INTERACT with Anacin. Tell your health care provider if you are taking any other medicines.

PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Anacin while you are pregnant. Anacin is not recommended during the last 3 months (third trimester) of pregnancy because it may cause harm to the fetus. Anacin is found in breast milk. If you are or will be breast-feeding while you use Anacin, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects. Anacin's side effects may include dizziness, heartburn, irritability, nausea, nervousness, rashes, hives, bloody stools, drowsiness, hearing loss, ringing in the ears, and trouble sleeping.

Check with your doctor if any of the listed above most COMMON side effects persist or become bothersome.

Seek medical attention right away if any of these SEVERE side effects occur: severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black or bloody stools; confusion; diarrhea; drowsiness; hearing loss; ringing in the ears; severe or persistent dizziness; severe or persistent stomach pain or heartburn; shakiness; trouble sleeping; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects.

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Calcidoc Kautabletten Pzn 01554781 Versandkostenfrei In Der Online Apotheke Bestellen, Calcidoc

CALCIDOC Kautabletten 60 Stuck

Art der Anwendung

Nehmen Sie die Kautabletten zu den Mahlzeiten ein.

Nehmen Sie das Arzneimittel immer genau nach der Anweisung in dieser Packungsbeilage ein. Bitte fragen Sie bei Ihrem Arzt oder Apotheker nach, wenn Sie sich nicht ganz sicher sind.

Falls vom Arzt nicht anders verordnet, ist die ubliche Dosis:

2-mal taglich 1 Kautablette (entsprechend 1200 mg ionisiertem Calcium und 800 I. E. Vitamin D3).

Dauer der Anwendung

Die Dauer der Einnahme richtet sich nach der Anordnung des Arztes.

Bitte sprechen Sie mit Ihrem Arzt, wenn Sie den Eindruck haben, dass die Wirkung des Arzneimittels zu stark oder zu schwach ist.

Wenn Sie eine gro?ere Menge des Arzneimittels eingenommen haben, als Sie sollten

Eine Uberdosierung fuhrt zu vermehrter Calciumausscheidung im Urin und zu einer Erhohung der Calcium-Konzentration im Blut mit folgenden Symptomen:

Ubelkeit, Erbrechen, Durst und gesteigertes Durstempfinden

vermehrtes Wasserlassen

Verstopfung.

Eine chronische Uberdosierung mit daraus resultierendem erhohtem Blut-Calciumspiegel kann zu Gefa? - und Organverkalkungen fuhren.

Bitte wenden Sie sich, wenn die oben genannten Symptome auftreten, umgehend an Ihren Arzt.

Wenn Sie die Einnahme des Arzneimittels vergessen haben

Nehmen Sie nicht die doppelte Menge nach einer vergessenen Einzeldosis ein, sondern bleiben Sie bei Ihrem Einnahme-Rhythmus.

Wenn Sie die Einnahme des Arzneimittels abbrechen

Sprechen Sie bitte mit Ihrem Arzt uber die weitere Vorgehensweise.

Wenn Sie weitere Fragen zur Anwendung des Arzneimittels haben, fragen Sie Ihren Arzt und Apotheker.

Zusammensetzung CALCIDOC Kautabletten:

Hinweise CALCIDOC Kautabletten 60 Stuck.

Besondere Vorsicht bei der Einnahme des Arzneimittels ist erforderlich

Sie durfen das Arzneimittel erst nach Rucksprache mit Ihrem Arzt einnehmen

wenn Sie fruher Nierensteine hatten

bei einer bestimmten Lungenerkrankung (Sarkoidose).

Wahrend einer Langzeitbehandlung mit dem Arzneimittel wird Ihr Arzt Ihren Serumcalciumspiegel kontrollieren und die Nierenfunktion uberwachen.

Die Uberwachung ist besonders wichtig, wenn Sie alter sind und wenn Sie als Begleitmedikation die Herzkraft steigernde Mittel (Herzglykoside) oder harntrei-bende Mittel (Diuretika) erhalten.

Bei Hyperkalzamie oder Anzeichen einer Nierenfunktionsstorung wird Ihr Arzt die Dosis reduzieren oder die Therapie abbrechen.

Wenn Sie unter einer bestimmten Lungenerkrankung (Sarkoidose) leiden, wird Ihnen Ihr Arzt dieses Arzneimittel wegen der Gefahr einer erhohten Verstoff-wechselung von Vitamin D in seine aktive Form nur mit Vorsicht verordnen. Der Calciumspiegel in Serum und Urin sollte in diesen Fallen vom Arzt uberwacht werden.

Bei gleichzeitiger Verordnung anderer Vitamin-D-Praparate muss die mit dem Arzneimittel verabreichte Tagesdosis von Vitamin D berucksichtigt werden. Eine zusatzliche Verabreichung von Vitamin D oder Calcium sollte unter arztlicher Uberwachung erfolgen. In solchen Fallen ist eine regelma?ige arztliche Uberwachung der Calciumspiegel in Serum und Urin erforderlich.

Falls Sie unter eingeschrankter Nierenfunktion (Niereninsuffizienz) leiden, wird Vitamin D in Form von Colecalciferol nicht normal verstoffwechselt. Daher soll-ten Sie andere Vitamin-D-Praparate erhalten.

Verkehrstuchtigkeit und das Bedienen von Maschinen

Es liegen keine Daten uber die Auswirkung auf die Verkehrstuchtigkeit vor, eine Beeinflussung ist jedoch unwahrscheinlich.

Gegenanzeigen CALCIDOC Kautabletten 60 Stuck.

Das Arzneimittel darf NICHT eingenommen werden

wenn Sie uberempfindlich (allergisch) gegenuber Calciumcarbonat und Colecalciferolsind

falls bei Ihnen eine Erhohung des Calciumspiegels im Blut (Hyperkalzamie) festgestellt wurde

wenn bei Ihnen eine vermehrte Calciumausscheidung im Urin (Hyperkalzurie) besteht

wenn Sie unter schweren Nierenfunktionsstorungen leiden.

Hinweise CALCIDOC Kautabletten 60 Stuck.

Besondere Vorsicht bei der Einnahme des Arzneimittels ist erforderlich

Sie durfen das Arzneimittel erst nach Rucksprache mit Ihrem Arzt einnehmen

wenn Sie fruher Nierensteine hatten

bei einer bestimmten Lungenerkrankung (Sarkoidose).

Wahrend einer Langzeitbehandlung mit dem Arzneimittel wird Ihr Arzt Ihren Serumcalciumspiegel kontrollieren und die Nierenfunktion uberwachen.

Die Uberwachung ist besonders wichtig, wenn Sie alter sind und wenn Sie als Begleitmedikation die Herzkraft steigernde Mittel (Herzglykoside) oder harntrei-bende Mittel (Diuretika) erhalten.

Bei Hyperkalzamie oder Anzeichen einer Nierenfunktionsstorung wird Ihr Arzt die Dosis reduzieren oder die Therapie abbrechen.

Wenn Sie unter einer bestimmten Lungenerkrankung (Sarkoidose) leiden, wird Ihnen Ihr Arzt dieses Arzneimittel wegen der Gefahr einer erhohten Verstoff-wechselung von Vitamin D in seine aktive Form nur mit Vorsicht verordnen. Der Calciumspiegel in Serum und Urin sollte in diesen Fallen vom Arzt uberwacht werden.

Bei gleichzeitiger Verordnung anderer Vitamin-D-Praparate muss die mit dem Arzneimittel verabreichte Tagesdosis von Vitamin D berucksichtigt werden. Eine zusatzliche Verabreichung von Vitamin D oder Calcium sollte unter arztlicher Uberwachung erfolgen. In solchen Fallen ist eine regelma?ige arztliche Uberwachung der Calciumspiegel in Serum und Urin erforderlich.

Falls Sie unter eingeschrankter Nierenfunktion (Niereninsuffizienz) leiden, wird Vitamin D in Form von Colecalciferol nicht normal verstoffwechselt. Daher soll-ten Sie andere Vitamin-D-Praparate erhalten.

Verkehrstuchtigkeit und das Bedienen von Maschinen

Es liegen keine Daten uber die Auswirkung auf die Verkehrstuchtigkeit vor, eine Beeinflussung ist jedoch unwahrscheinlich.

Nebenwirkungen CALCIDOC Kautabletten 60 Stuck.

Wie alle Arzneimittel kann dieses Arzneimittel Nebenwirkungen haben, die aber nicht bei jedem auftreten mussen.

Verstopfung, Blahungen, Ubelkeit, Magenschmerzen, Durchfall, Hyperkalzamie und Hyperkalzurie konnen auftreten.

Informieren Sie bitte Ihren Arzt oder Apotheker, wenn eine der aufgefuhrten Nebenwirkungen Sie erheblich beeintrachtigt oder Sie Nebenwirkungen bemerken, die nicht in dieser Gebrauchsinformation angegeben sind.

Bei Einnahme des Arzneimittels mit anderen Arzneimitteln

Bitte informieren Sie Ihren Arzt oder Apotheker, wenn Sie andere Arzneimittel anwenden bzw. vor kurzem angewendet haben, auch wenn es sich um nicht verschreibungspflichtige Arzneimittel handelt.

Die gleichzeitige Behandlung mit Phenytoin (Mittel gegen Epilepsie und gegen bestimmte Herzrhythmusstorungen) oder Barbituraten (Schlafmittel) kann die Wirkung von Vitamin D3 vermindern, was auf einen erhohten Stoffwechsel zuruckzufuhren ist.

Bei gleichzeitiger Einnahme von bestimmten harntreibenden Mitteln (Diuretika vom Thiazid-Typ) besteht ein erhohtes Hyperkalzamie-Risiko, weil Thiazid-Diuretika die tubulare Calcium-Ruckresorption erhohen. Bei einer Langzeitanwendung sollten die Calciumspiegel im Serum uberwacht werden.

Bei gleichzeitiger Behandlung mit die Herzkraft steigernden Arzneimitteln (Herzglykosiden) konnen sich deren unerwunschte Nebenwirkungen erhohen (Gefahr von Herzrhythmusstorungen). Patienten, die Herzglykoside erhalten, mussen arztlich uberwacht werden (EKG, Serumcalciumspiegel).

Bei gleichzeitiger Einnahme von Levothyroxin (Schilddrusenhormonersatzmittel) und dem Arzneimittel kann die Aufnahme von Levothyroxin vermindert sein. Aus diesem Grund sollte zwischen der Einnahme von Levothyroxin und dem Arzneimittel ein Abstand von mindestens 4 Stunden liegen.

Die Aufnahme von oralen Tetracyclinen (Antibiotika) kann durch die gleichzeiti-ge Einnahme des Arzneimittels vermindert werden. Zwischen der Einnahme von Tetracyclinen und dem Arzneimittel sollte ein Abstand von 3 Stunden eingehalten werden.

Bei gleichzeitiger Behandlung mit Chinolon-Antibiotika sollten diese wegen der Gefahr einer verminderten Aufnahme mindestens 4 Stunden vor oder nach der Einnahme des Arzneimittels verabreicht werden.

Bei gleichzeitiger Einnahme von Glukokortikoiden (Mittel zur Unterdruckung der Immunabwehr und bei bestimmten Entzundungen) kann die Wirksamkeit von Vitamin D herabgesetzt werden.

Bei gleichzeitiger Behandlung mit Bisphosphonat - oder Natriumfluorid-Praparaten (Mittel gegen Osteoporose) und dem Arzneimittel sollten diese wegen des Risikos einer eingeschrankten Aufnahme mindestens 2 Stunden vor dem Arzneimittel eingenommen werden.

Beachten Sie bitte, dass diese Angaben auch fur vor kurzem angewandte Arzneimittel gelten konnen.

Bei Einnahme des Arzneimittels zusammen mit Nahrungsmitteln und Getranken

Nahrungsmittel, die einen hohen Anteil an Phosphat, Phytin - oder Oxalsaure haben, konnen die Calciumaufnahme hemmen.

Schwangerschaft und Stillzeit

Fragen Sie vor der Anwendung von allen Arzneimitteln Ihren Arzt oder Apothe-ker um Rat.

Wahrend der Schwangerschaft sollte das Arzneimittel nur nach strenger Nutzen-Risiko-Abwagung durch den Arzt eingenommen und nur so dosiert werden, wie es zum Beheben des Mangels unbedingt notwendig ist. Uberdosierungen von Vitamin D in der Schwangerschaft mussen verhindert werden, da eine langanhaltende Hyperkalzamie zu korperlicher und geistiger Behinderung, Aortenverengung (supravalvularer Aortenstenose) und Netzhauterkrankungen (Retinopathie) des Kindes fuhren kann.

Vitamin D und seine Stoffwechselprodukte gehen in die Muttermilch uber. Eine auf diesem Wege erzeugte Uberdosierung beim Saugling ist nicht beobachtet worden.

So konnen Sie bezahlen Wir akzeptieren als Zahlungsweisen Rechnung, Lastschrift, PayPal, Vorkasse, Amazon Payments, Sofortuberweisung und Kreditkarte.

Theodrip Generic Name Theophylline Online, Theodrip

Theodrip General Information

Theodrip - Pharmacology:

Theodrip relaxes the smooth muscle of the bronchial airways and pulmonary blood vessels and reduces airway responsiveness to histamine, methacholine, adenosine, and allergen. Theodrip competitively inhibits type III and type IV phosphodiesterase (PDE), the enzyme responsible for breaking down cyclic AMP in smooth muscle cells, possibly resulting in bronchodilation. Theodrip also binds to the adenosine A2B receptor and blocks adenosine mediated bronchoconstriction.

Theodrip for patients

Immediate Release Products

The patient (or parent/care giver) should be instructed to seek medical advice whenever nausea, vomiting, persistent headache, insomnia or rapid heart beat occurs during treatment with theophylline, even if another cause is suspected. The patient should be instructed to contact their clinician if they develop a new illness, especially if accompanied by a persistent fever, if they experience worsening of a chronic illness, if they start or stop smoking cigarettes or marijuana, or if another clinician and a new medication or discontinues a previously prescribed medication. Patients should be instructed to inform all clinicians involved in their care that they are taking theophylline, especially when a medication is being added or deleted from their treatment. Patients should be instructed to not alter the dose, timing of the dose, or frequency of administration without first consulting their clinician. If a dose is missed, the patient should be instructed to take the next dose at the usually scheduled time and to not attempt to make up for the missed dose.

This information is intended to aid in the safe and effective use of this medication. It is not a disclosure of all possible adverse or intended effects.

The physician should reinforce the importance of taking only the prescribed dose and the time interval between doses. As with any controlled-release theophylline product, the patient should alert the physician of symptoms occur repeatedly, especially near the end of the dosing interval.

When prescribing administration by the sprinkle method, details of the proper technique should be explained to patient

Patients should be informed of the need to take this drug in the fasting state, and that drug administration should be 1 hour before or 2 hours after meals.

This description is suitable for active ingredient Theophylline

Theodrip Interactions

Theodrip interacts with a wide variety of drugs. The interaction may be pharmacodynamic, i. e. alterations in the therapeutic response to theophylline or another drug or occurrence of adverse effects without a change in serum theophylline concentration. More frequently, however, the interaction is pharmacokinetic, i. e. the rate of theophylline clearance is altered by another drug resulting in increased or decreased serum theophylline concentrations. Theodrip only rarely alters the pharmacokinetics of other drugs.

The drugs listed in TABLES 2A and 2B have the potential to produce clinically significant pharmacodynamic or pharmacokinetic interactions with theophylline. The information in the "Effect" column of TABLES 2A and 2B assumes that the interacting drug is being added to a steady-state theophylline regimen. If theophylline is being initiated in a patient who is already taking a drug that inhibits theophylline clearance ( e. g., cimetidine, erythromycin), the dose of theophylline required to achieve a therapeutic serum theophylline concentration will be smaller. Conversely, if theophylline is being initiated in a patient who is already taking a drug that enhances theophylline clearance ( e. g., rifampin), the dose of theophylline required to achieve a therapeutic serum theophylline concentration will be larger. Discontinuation of a concomitant drug that increases theophylline clearance will result in accumulation of theophylline to potentially toxic levels, unless the theophylline dose is appropriately reduced. Discontinuation of a concomitant drug that inhibits theophylline clearance will result in decreased serum theophylline concentrations, unless the theophylline dose is appropriately increased.

The listing of drugs in TABLES 2A and 2B is current as of April 3, 1995. New interactions are continuously being reported for theophylline, especially with new chemical entities. The clinician should not assume that a drug does not interact with theophylline if it is not listed in TABLES 2A and 2B. Before addition of a newly available drug in a patient receiving theophylline, the package insert of the new drug and/or the medical literature should be consulted to determine if an interaction between the new drug and theophylline has been reported.

TABLE 2A - Clinically significant drug interactions with theophylline*

Type of Interaction

** Average effect on steady state theophylline concentration or other clinical effect for pharmacologic interactions. Individual patients may experience larger changes in serum theophylline concentration than the value listed.

The Effect of Other Drugs on Theodrip Serum Concentration Measurements: Most serum theophylline assays in clinical use are immunoassays which are specific for theophylline. Other xanthines such as caffeine, dyphylline, and pentoxifylline are not detected by these assays. Some drugs ( e. g. . cefazolin, cephalothin), however, may interfere with certain HPLC techniques. Caffeine and xanthine metabolites in neonates or patients with renal dysfunction may cause the reading from some dry reagent office methods to be higher than the actual serum theophylline concentration.

Theodrip Contraindications

This product is contraindicated in individuals who have shown hypersensitivity to its components. It is also contraindicated in patients with active peptic ulcer disease, and in individuals with underlying seizure disorders (unless receiving appropriate anti-convulsant medication).

This description is suitable for active ingredient Theophylline

Generic name, Overdose, Half Life Theodrip, Food Interactions, Chemical, etc..

Theodrip see also

Quilter Amps, Problok

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The Quilter ProBlock 200 is a next generation guitar head powerful enough to take on even the most heavyweight amp, but light enough and small enough to cozy up on your board with your favorite pedals. With rack mounting options, you can even build the ultimate stereo amplifier for your rack modelers. With all the tone of Quilter Lab's next generation solid state technology, it is going to feel like you plugged into a tube amp. All analog, no emulation, just amazing tone.

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Some Antidepressants Might Actually Be Harmful To Children And Teens, Lanvexin

A discouraging new study concludes that most antidepressants are ineffective for children and adolescents, and may even be harmful in some cases. But the researchers caution that the low quantity and quality of clinical trials are obscuring the true effects of these drugs.

For the new Lancet study. researchers analyzed 34 trials involving over 5,000 participants aged nine to 18. Out of the 14 antidepressant drugs scrutinized, only fluoxetine (aka Prozac) was more effective at relieving the symptoms of depression than a placebo. Shockingly, venlafaxine (branded as Effexor and Lanvexin) was actually associated with an increased risk of suicidal thoughts and attempts when compared to a placebo and several other antidepressants. Patients found that imipramine, venlafaxine, and duloxetine had such negative effects that they were likely to stop taking the drugs.

“The balance of risks and benefits of antidepressants for the treatment of major depression does not seem to offer a clear advantage in children and teenagers, with probably only the exception of fluoxetine,” noted study co-author Peng Xie of Chongqing Medical University in China.

In light of these findings, the researchers recommend that children and teens who are taking antidepressants be monitored closely, regardless of which drugs they are taking, and especially at the beginning of treatment. The researchers stopped short of suggesting that children be taken off their meds; previous research has shown that withholding antidepressants from children and teens can be dangerous.

“Without access to individual-level data it is difficult to get accurate effect estimates and we can’t be completely confident about the accuracy of the information contained in published and unpublished trials.” - Andrea Cipriani

But the researchers caution that the true effectiveness and risks of these drugs remain unclear due to the disturbingly small number of clinical trials, many of which are flawed. Selective reporting of findings in published trials and clinical study reports were also blamed.

Indeed, there appears to be some selectivity at play here, and no small amount of reporting bias. Of the 34 trials analyzed, 65 percent were funded by pharmaceutical companies. The researchers ranked nearly 30 percent of the trials as being at high risk of bias, 59 percent as moderate, and just 12 percent as low.

“Without access to individual-level data it is difficult to get accurate effect estimates and we can’t be completely confident about the accuracy of the information contained in published and unpublished trials,” said lead author Dr Andrea Cipriani, who works out of the University of Oxford. “It has been widely argued that there needs to be a transformation of existing scientific culture to one where responsible data sharing should be the norm.” Cipriani said that scientists should be given access to raw clinical trial data in order to validate and replicate existing findings.

Publication bias in pharmaceutical research is a known problem. Back in 2004, biotech giant GlaxoSmithKline not only failed to show treatment effectiveness for off-label use of the anti-anxiety drug Paxil among children and teens, it also failed to note a possible increased risk of suicidal tendencies in this age group.

But Big Pharma doesn’t deserve all of the blame—the current publishing model is likewise culpable. It’s easier to publish positive results than inconclusive results, leading to yet another form of publication bias. As Cipriani and her colleagues rightly point out, something has to change.

Acetazolamide Medical Facts From, Acetazolamid

acetazolamide

Acetazolamide reduces the activity of a protein in your body called carbonic anhydrase. Blocking this protein can help reduce the build-up of certain fluids in the body.

Acetazolamide is used in people with certain types of glaucoma to reduce the amount of fluid in the eye, which decreases pressure inside the eye.

Acetazolamide is also used as a diuretic ("water pill") in people with congestive heart failure, to reduce the build-up of fluid in the body. This build-up is called edema.

Acetazolamide is also used to treat certain types of seizures, and to treat or prevent altitude sickness.

Acetazolamide may also be used for purposes not listed in this medication guide.

What is the most important information I should know about acetazolamide?

You should not use this medicine if you have cirrhosis, severe liver or kidney disease, an electrolyte imbalance, adrenal gland failure, or an allergy to acetazolamide or sulfa drugs.

What should I discuss with my healthcare provider before taking acetazolamide?

You should not use acetazolamide if you are allergic to it, or if you have:

severe liver disease, or cirrhosis;

severe kidney disease;

an electrolyte imbalance (such as acidosis or low levels of potassium or sodium in your blood);

adrenal gland failure; or

an allergy to sulfa drugs.

To make sure acetazolamide is safe for you, tell your doctor if you have:

severe breathing problems;

angle closure glaucoma; or

if you also take aspirin in high doses.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Acetazolamide can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.

Acetazolamide is not approved for use by anyone younger than 18 years old.

How should I take acetazolamide?

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Your dose of this medicine will depend on the condition you are treating. If you take acetazolamide for congestive heart failure, your doctor may tell you to skip your medication for a day. Follow your doctor's dosing instructions very carefully.

Take this medicine with a full glass of water.

While using acetazolamide, you may need frequent blood tests.

Acetazolamide may be only part of a complete treatment program that may also include other medications. Follow your doctor's instructions very closely.

Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking acetazolamide?

This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Avoid exposure to sunlight or tanning beds. Acetazolamide can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

Acetazolamide side effects

Get emergency medical help if you have signs of an allergic reaction . hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

blood in urine or stools;

a seizure (convulsions);

loss of movement in any part of your body;

a blood cell disorder--sudden weakness or ill feeling, fever, chills, sore throat, mouth sores, pale skin, feeling tired or short of breath, rapid heart rate, nosebleeds, bleeding gums;

liver problems--nausea, upper stomach pain or swelling, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

signs of metabolic acidosis--confusion, vomiting, lack of energy, irregular heartbeats;

signs of a kidney stone--pain in your side or lower back, blood in your urine, painful or difficult urination; or

severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Common side effects may include:

nausea, vomiting, loss of appetite, diarrhea;

numbness or tingling, especially in your arms and legs;

hearing problems, ringing in your ears;

increased urination; or

altered sense of taste.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Acetazolamide dosing information

Usual Adult Dose for Edema:

250 to 375 mg oral or IV once a day.

When continued acetazolamide therapy for edema is desired, it is recommended that every second or third dose be skipped to allow the kidney to recover.

Usual Adult Dose for Acute Mountain Sickness:

Oral tablet: 125 to 250 mg orally every 6 to 12 hours. - or - SR capsule: 500 mg orally every 12 to 24 hours.

The maximum recommended dose is 1 gram/day. For rapid ascent, higher doses are beneficial for preventing acute mountain sickness beginning 24 to 48 hours before ascent and continuing for 48 hours while at high altitude.

Usual Adult Dose for Glaucoma:

tablet or IV injection: 250 mg 1 to 4 times a day. - or - SR capsule: 500 mg once or twice a day.

250 to 500 mg IV, may repeat in 2 to 4 hours to a maximum of I gram/day.

Usual Adult Dose for Seizure Prophylaxis:

8 to 30 mg/kg/day in 1 to 4 divided doses. Do not exceed 1 gram per day.

If this patient is already taking other anticonvulsants, the recommended starting dosage is 250 mg once a day. If acetazolamide is used alone, most patients with good renal function respond to daily doses ranging from 375 to 1000 mg. The optimum dosage for this patient with renal dysfunction is not known, and will depend on this patient's clinical response and tolerance.

Acetazolamide is primarily used for the treatment of refractory epilepsy in combination with other drugs. Although it may be useful in partial, myoclonic, absence, and primary generalized tonic-clonic seizures uncontrolled by other marketed agents, it has been inadequately studied by current standards for these conditions.

Usual Pediatric Dose for Glaucoma:

Oral: 8 to 30 mg/kg/day or 300 to 900 mg/m?/day divided every 8 hours. - or - IV: 20 to 40 mg/kg/day divided every 6 hours.

Maximum dose: 1 gram/day.

Usual Pediatric Dose for Edema:

Oral or IV: 5 mg/kg or 150 mg/m? once a day.

Usual Pediatric Dose for Epilepsy:

Oral: 8 to 30 mg/kg/day in 1 to 4 divided doses. Maximum dose is 1 gram/day.

Usual Pediatric Dose for Hydrocephalus:

Drugs. com Mobile Apps

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Common Side Effects Of Toviaz (Fesoterodine Fumarate Extended-Release Tablets) Drug Center, Trovensi

For Patients

Last reviewed on RxList 10/6/2015

Toviaz (fesoterodine fumarate) is a muscarinic receptor antagonist. which reduces spasms of the bladder muscles, used to treat overactive bladder with symptoms of urinary frequency, urgency, and incontinence. Common side effects of Toviaz include dry mouth. dry eyes. constipation, dizziness, drowsiness, blurred vision, stomach pain or upset, cough, dry throat, back pain, or sleep problems (insomnia).

The recommended starting dose of Toviaz is 4 mg once daily. Based upon individual response and tolerability, the dose may be increased to 8 mg once daily. Toviaz may interact with arsenic trioxide, conivaptan. antibiotics, antifungals, antidepressants. anti-malaria medications, heart rhythm medicines, HIV /AIDS medicines, medicine to prevent or treat nausea and vomiting. medicines to treat psychiatric disorders, migraine headache medicines, or narcotics. Tell your doctor all medications you use. During pregnancy, Toviaz should be used only when prescribed. It is unknown if this drug passes into breast milk and the effect on a nursing infant is unknown. Consult your doctor before breast-feeding.

Our Toviaz (fesoterodine fumarate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Patient Information in Detail?

Easy-to-read and understand detailed drug information and pill images for the patient or caregiver from Cerner Multum.

Toviaz in Detail - Patient Information: Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using fesoterodine and call your doctor at once if you have a serious side effect such as:

chest pain, fast or uneven heart rate;

swelling of your hands or feet;

urinating less than usual or not at all; or

painful or difficult urination.

Less serious side effects may include:

dry mouth, dry eyes;

blurred vision;

dizziness, drowsiness;

constipation;

stomach pain or upset;

cough, dry throat;

back pain; or

sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is Patient Information Overview?

A concise overview of the drug for the patient or caregiver from First DataBank.

Toviaz Overview - Patient Information: Side Effects

SIDE EFFECTS: Dry mouth, dry eyes, constipation, dizziness, drowsiness, or blurred vision may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

To relieve dry mouth, suck on (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water or use a saliva substitute.

To prevent constipation, maintain a diet adequate in fiber, drink plenty of water, and exercise. If you become constipated, consult your pharmacist for help in choosing a laxative (such as stimulant-type with stool softener).

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: constipation lasting 3 or more days, severe stomach/abdominal pain, trouble urinating, signs of kidney infection (such as burning/painful urination, lower back pain, fever).

Seek immediate medical attention if any of these rare but serious side effects occur: fast heartbeat, fainting.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any of the following signs of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

ALT = alanine aminotransferase; GGT = gamma glutamyltransferase

Patients also received Toviaz for up to three years in open-label extension phases of one Phase 2 and two Phase 3 controlled trials. In all open-label trials combined, 857, 701, 529, and 105 patients received Toviaz for at least 6 months, 1 year, 2 years, and 3 years, respectively. The adverse events observed during long-term, open-label studies were similar to those observed in the 12-week, placebo-controlled studies, and included dry mouth, constipation, dry eyes, dyspepsia, and abdominal pain. Similar to the controlled studies, most adverse events of dry mouth and constipation were mild to moderate in intensity. Serious adverse events, judged to be at least possibly related to study medication by the investigator and reported more than once during the open-label treatment period of up to 3 years, included urinary retention (3 cases), diverticulitis (3 cases), constipation (2 cases), irritable bowel syndrome (2 cases), and electrocardiogram QT corrected interval prolongation (2 cases).

Post-marketing Experience

The following events have been reported in association with fesoterodine use in worldwide post-marketing experience: Eye disorders: Blurred vision; Cardiac disorders: Palpitations ; General disorders and administrative site conditions: Hypersensitivity reactions, including angioedema with airway obstruction, face edema; Central nervous system disorders: Dizziness, headache, somnolence ; Skin and subcutaneous tissue disorders: Urticaria, pruritus

Because these spontaneously reported events are from the worldwide post-marketing experience, the frequency of events and the role of fesoterodine in their causation cannot be reliably determined.

Related Resources for Toviaz

Related Health

Related Drugs

© Toviaz Patient Information is supplied by Cerner Multum, Inc. and Toviaz Consumer information is supplied by First Databank, Inc. used under license and subject to their respective copyrights.

Madlexin Generic Name Cephalexin Online, Madlexin

Madlexin General Information

Madlexin - Pharmacology:

Madlexin, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cephalexin interferes with an autolysin inhibitor.

Madlexin for patients

Patients should be counseled that antibacterial drugs including Keflex should only be used to treat bacterial infections. They do not treat viral infections (e. g. the common cold). When Keflex is prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed. Skipping doses or not completing the full course of therapy may (1) decrease the effectiveness of the immediate treatment and (2) increase the likelihood that bacteria will develop resistance and will not be treatable by Keflex or other antibacterial drugs in the future.

This description is suitable for active ingredient Cephalexin

Madlexin Interactions

Metformin In healthy subjects given single 500 mg doses of cephalexin and metformin, plasma metformin mean c max and AUC increased by an average of 34% and 24%, respectively, and metformin mean renal clearance decreased by 14%. No information is available about the interaction of cephalexin and metformin following multiple doses of either drug.

Although not observed in this study, adverse effects could potentially arise from co-administration of cephalexin and metformin by inhibition of tubular secretion via organic cationic transporter systems. Accordingly, careful patient monitoring and dose adjustment of metformin is recommended in patients concomitantly taking cephalexin and metformin.

Probenecid As with other b-lactams, the renal excretion of cephalexin is inhibited by probenecid.

Drug / Laboratory Test Interactions

As a result of administration of Keflex, a false-positive reaction for glucose in the urine may occur. This has been observed with Benedictis and Fehlingis solutions and also with Clinitest® tablets.

Madlexin Contraindications

Shop - Molken Music Online, Molken

Xenuphobe - "Drone" (MP3)

XENUPHOBE (pronounced "zee-nu-fobe") is the psychoactive, ambient collaboration between guitarists TY TABOR (King's X), WALLY FARKAS (Galactic Cowboys/dUg Pinnick's Texas Poundation), and JAMES HENRY (previously known as "Eddie Hash").

"Drone" was recorded live at Molken Studios and focuses on a darker space than previous offerings. Using electric guitars, vintage amps, and digital/analog effects pedals only, the guys delve into musical realms usually ruled by synths.

This hour-long piece has been divided into thirteen tracks but is meant to be experienced as a whole.

All recordings previously unreleased. 13 songs. 62 minutes.

Ty Tabor - "Nobody Wins When Nobody Plays" (MP3)

$12.99 "Nobody Wins When Nobody Plays" is Ty Tabor's seventh studio release, featuring twelve new tracks. "Nobody Wins When Nobody Plays" showcases what everyone loves and expects from Tabor: guitar-laden rock and pop with beautiful melodies. Contains the singles, "Senseless Paranoia," "Tripped Inside Again," and "Listen."

All recordings previously unreleased. 12 songs. 43 minutes.

Ty Tabor - "Almost Live from Alien Beans Studio" (WAV)

This is the companion audio for Ty Tabor's recently released DVD, "Almost Live from Alien Beans Studio", which is the first-ever DVD release from Ty Tabor. With a well stocked arsenal of guitars and amps, Ty takes you through several deep cuts spanning his nearly 20 year solo career.

On "Almost Live from Alien Beans Studio" Ty performs live in the studio, accompanying himself with full instrumentation.

Each track is recorded "live".

All new recordings. 11 tracks. 37 minutes.

King's X - "Burning Down Boston: Live at The Channel 6.12.91" (MP3) - FREE WITH $20 GIFT

"Burning Down Boston: Live at The Channel 6.12.91" is a special MP3 download-only title. As many of you are aware, King's X drummer Jerry Gaskill suffered a serious heart attack in the early morning hours on Sunday 2.26.12. Many of you have overwhelmingly expressed a desire to help and contribute. We have compiled this exclusive live release from the archives -- and 100% of the proceeds from this release will go directly to Jerry to help offset mounting medical expenses. A big THANK YOU goes out to everyone for the outpouring of concern and love.

This release was edited and mastered from a stereo FOH recording. While the audio is far from perfect sonically, the performance documents yet another magical night on tour while supporting the "Faith Hope Love" album. While many of the song titles are familiar, the band expands many of the cuts featured here, including performances that are blistering ("Moanjam"),heavy and funk-laden ("We Are Finding Who We Are"), beautiful ("The Burning Down"), and truly transcendental ("Over My Head").

A few songs from the show were omitted due to tape damage. However, we have included three bonus tracks (an additional 15 minutes) from the same show that were not presented in the main track listing.

All recordings previously unreleased. 14 songs. 89 minutes.

Dear Friends, in addition to the gift with this download, please let anyone who wants to further make a personal gift to Jerry to help him with his medical bills know that they can send a check made out to Jerry Gaskill. Mail it to: Jerry Gaskill, c/o World Entertainment Inc. P. O. Box 3095, Sea Bright, NJ 07760. 100% of your gift goes to Jerry Gaskill to help him defray his medical bills. Jerry Gaskill is an individual and not a charity. Any funds given to him would be a gift and no further tax deduction for charitable contributions would be coming from him. We appreciate your help.

The Jelly Jam - "Shall We Descend" (MP3)

"Shall We Descend" is the brand-new, third album by The Jelly Jam. This trio is comprised of Ty Tabor (King's X), John Myung (Dream Theater) and Rod Morgenstein (Dixie Dregs/Winger).

"Shall We Descend" is the long-awaited follow up to "2" (originally released in 2004). This album is heavy, cohesive, and sure to please fans of this great band. Features the first single, "Who's Comin' Now" as well as gems such as "Halos in Hell" and "Stay Together."

Rod Morgenstein - Drums, Percussion John Myung - Bass Ty Tabor - Vocals, Guitars

10 songs. 48 minutes.

The Jelly Jam - "Additives" (MP3)

Features of this release include:

* Previously unheard audio from the practice sessions that yielded the 2nd album.

* Complete STEM mixes for the song, "I Can't Help You" (album version on the debut album). Stem mixes are hi-res stereo MP3 files with isolated vocals and instrument reduction tracks. Anyone with basic digital audio editing software can virtually remix the entire song. Hear the individual performances of each band member. Have fun, add your own parts, etc. along with the band!

The following 6 stem mixes for "I Can't Help You" are included as individual MP3 files:

- Drums - Bass - Rhythm Guitars - Lead Guitar - Lead Vocals - Backing Vocals

* Also included in "Additives" are 4 Ringtones of Jelly Jam tunes. Each ringtone is included as a *M4R (Ringtone) file as well as an MP3 file.

The following 4 ringtones are included:

- "Nature's Girl" (from "The Jelly Jam") - "I Am the King" (from "The Jelly Jam") - "Not Today" (from "2") - "Allison" (from "2")

Rod Morgenstein - Drums, Percussion John Myung - Bass Ty Tabor - Vocals, Guitars

1 song. 5:32 minutes. 6 stem mixes. 3:03 minutes (total length of song) 4 Ringtones. 1:30 minutes total (*m4r files) 4 Ringtones. 1:30 minutes total (*mp3 files)

**Stem mixes for "I Can't Help You" are for personal use. Individual stem tracks cannot be used in any other way without prior written approval from Molken Music and The Jelly Jam. (This includes public uploads.)**

Buy Arthritis - Dolofen-F (Brand Name Motrin) Online - Order Ibuprofen - Purchase Arthritis - Dolofe

Motrin is used for treating rheumatoid arthritis, osteoarthritis, menstrual cramps, or mild to moderate pain. Motrin is an NSAID. NSAIDs treat the symptoms of pain and inflammation. They do not treat the disease that causes those symptoms.

Use Motrin as directed by your doctor.

Take Motrin by mouth with or without food. It may be taken with food if it upsets your stomach. Taking it with food may not lower the risk of stomach or bowel problems (eg, bleeding, ulcers). Talk with your doctor or pharmacist if you have persistent stomach upset.

Take Motrin with a full glass of water (8 oz/240 mL) as directed by your doctor.

If you miss a dose of Motrin and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose. Go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about the proper use of Motrin .

Store Motrin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Motrin out of the reach of children and away from pets.

Active Ingredient: Ibuprofen.

Do NOT use Motrin if:

you are allergic to any ingredient in Motrin

you have had a severe allergic reaction (eg, severe rash, hives, trouble breathing, growths in the nose, dizziness) to aspirin or an NSAID (eg, ibuprofen, celecoxib)

you have recently had or will be having bypass heart surgery

you are in the last 3 months of pregnancy.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Motrin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal product, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of kidney or liver disease, diabetes, or stomach or bowel problems (eg, bleeding, perforation, ulcers)

if you have a history of swelling or fluid buildup, lupus, asthma, or growths in the nose (nasal polyps), or mouth inflammation

if you have high blood pressure, blood disorders, bleeding or clotting problems, heart problems (eg, heart failure), or blood vessel disease, or if you are at risk for any of these diseases

if you have poor health, dehydration or low fluid volume, or low blood sodium levels, you drink alcohol, or you have a history of alcohol abuse.

Some medicines may interact with Motrin. Tell your health care provider if you are taking any other medicines, especially any of the following:

Anticoagulants (eg, warfarin), aspirin, corticosteroids (eg, prednisone), heparin, or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) because the risk of stomach bleeding may be increased

Probenecid because it may increase the risk of Motrin 's side effects

Cyclosporine, lithium, methotrexate, or quinolones (eg, ciprofloxacin) because the risk of their side effects may be increased by Motrin

Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril) or diuretics (eg, furosemide, hydrochlorothiazide) because their effectiveness may be decreased by Motrin.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Motrin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Motrin may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Motrin with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Serious stomach ulcers or bleeding can occur with the use of Motrin. Taking it in high doses or for a long time, smoking, or drinking alcohol increases the risk of these side effects. Taking Motrin with food will NOT reduce the risk of these effects. Contact your doctor or emergency room at once if you develop severe stomach or back pain; black, tarry stools; vomit that looks like blood or coffee grounds; or unusual weight gain or swelling.

Do not take more than the recommended dose or use for longer than prescribed without checking with your doctor.

Motrin has ibuprofen in it. Before you start any new medicine, check the label to see if it has ibuprofen in it too. If it does or if you are not sure, check with your doctor or pharmacist.

Do not take aspirin while you are using Motrin unless your doctor tells you to.

Lab tests, including kidney function, complete blood cell counts, and blood pressure, may be done to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.

Use Motrin with caution in the elderly; they may be more sensitive to its effects, including stomach bleeding and kidney problems.

Motrin should be used with extreme caution in children; safety and effectiveness in children have not been confirmed.

Pregnancy and breast-feeding: Motrin may cause harm to the fetus. Do not take it during the last 3 months of pregnancy. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Motrin while you are pregnant. It is not known if Motrin is found in breast milk. Do not breastfeed while taking Motrin .

All medicines can cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Constipation; diarrhea; dizziness; gas; headache; heartburn; nausea; stomach pain or upset.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; trouble breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody or black, tarry stools; change in the amount of urine produced; chest pain; confusion; dark urine; depression; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; mental or mood changes; numbness of an arm or leg; one-sided weakness; red, swollen, blistered, or peeling skin; ringing in the ears; seizures; severe headache or dizziness; severe or persistent stomach pain or nausea; severe vomiting; shortness of breath; stiff neck; sudden or unexplained weight gain; swelling of hands, legs, or feet; unusual bruising or bleeding; unusual joint or muscle pain; unusual tiredness or weakness; vision or speech changes; vomit that looks like coffee grounds; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Allergic Reaction Causes, Symptoms, Treatment - What Causes An Allergic Reaction, Allergica

IN THIS ARTICLE

What Causes an Allergic Reaction?

Almost anything can trigger an allergic reaction.

The body's immune system involves the white blood cells, which produce antibodies.

When the body is exposed to an antigen (a foreign body such as pollen that can trigger an immune response), a complex set of reactions begins.

The white blood cells produce an antibody specific to that antigen. This is called "sensitization."

The job of the antibodies is to help white blood cells detect and destroy substances that cause disease and sickness. In allergic reactions, the antibody belongs to the class of immunoglobulins known as immunoglobulin E or IgE.

This antibody type promotes production and release of chemicals and hormones called "mediators."

Mediators have effects on local tissue and organs in addition to activating more white blood cell defenders. It is these effects that cause the symptoms of the reaction.

Histamine is one of the better-known allergy mediators produced by the body.

If the release of the mediators is sudden or extensive, the allergic reaction may also be sudden and severe, and anaphylaxis may occur.

Allergic reactions are unique for each person. Reaction time to allergens can vary widely. Some people will have an allergic reaction immediately; for others, it will take time to develop.

Most people are aware of their particular allergy triggers and reactions.

There are more than 160 allergenic foods. Certain foods are common allergens, including peanuts, strawberries, shellfish, shrimp, dairy, and wheat.

Babies can also have food allergies. Common foods that can cause allergic reactions in babies include milk, eggs, nuts, and soy. People should talk to their child's pediatrician if they are concerned about food allergies in their baby.

Food intolerance is not the same as food allergies. Allergies are an immune system response, while food intolerance is a digestive system response in which a person is unable to properly digest or break down a particular food.

People can be allergic to wheat but not gluten. According to the American College of Allergy, Asthma & Immunology, there is no such thing as a gluten allergy; but one can have a sensitivity to this protein that results in gastrointestinal symptoms.

Certain fruits or vegetables may cause an itchy mouth or scratchy throat after eating in people who have oral allergy syndrome.

Seasonal allergic rhinitis (also called hay fever) is an allergy that occurs in the spring, summer, or early fall caused by allergies to pollens from trees, grasses or weeds, or to mold spores.

Vaccines and medications (antibiotics such as penicillin and amoxicillin, aspirin. ibuprofen, iodine), general anesthesia and local anesthetics, latex rubber (such as in gloves or condoms ), dust, mold or other fungi, animal dander from pets and other animals, and poison ivy are well-known allergens. Other known allergens can include detergents, hair dyes, cosmetics. and the ink in tattoos.

Bee stings, fire ant stings, penicillin, and peanuts are known for causing dramatic reactions that can be serious and involve the whole body.

Minor injuries, hot or cold temperatures, exercise. stress. or emotions may trigger allergic reactions.

Sun exposure may cause allergic reactions in some people, often referred to as "sun poisoning ."

Often, the specific allergen cannot be identified unless someone has had a similar reaction in the past.

Allergies, and the tendency to have allergic reactions, is hereditary -- that is, it runs in some families.

Many people who have one trigger tend to have other triggers, as well.

Risk factors for allergic reactions include certain medical conditions that can make a person more likely to have allergic reactions:

Severe allergic reaction in the past

Asthma

Lung conditions that affect breathing, such as chronic obstructive pulmonary disease (COPD )

Nasal polyps

Frequent infections of the nasal sinuses, ears, or respiratory tract

Sensitive skin, especially sufferers of eczema

Medically Reviewed by a Doctor on 4/12/2016

What Are Symptoms and Signs of an Allergic Reaction? »

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honeybees,.

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Read What Your Physician is Reading on Medscape

Medical Dictionary

Theophylline - Xpharm The Comprehensive Pharmacology Reference, Spophyllin

Theophylline

Theophylline is a methylxanthine used as a bronchodilator. It relaxes bronchial smooth muscles by increasing levels of cyclic AMP through nonselective inhibition of phosphodiesterase. Theophylline is also an adenosine receptor antagonist.

Nomenclature

Name of the Clinical Form

Theophylline, theophylline hydrate

Related Names Source: EMTREE

Accurbron; Acrobin; Aerolate; Afonilum; Armophylline, Austyn; Bilordyl; Bronchoretard; Bronkodyl; Cetraphyllline; Duraphyllin; Diffumal; Elixophyllin; Etheophyl; Euphyllin; Euphylong; LaBID; Lasma; Nuelin; Physpan; Pro-Vent; PulmiDur; Pulmo-Timelets; Respbid; Slo-Bid; Slo-Phyllin; Solosin; Talotren; Teosona; Theobid; Theoclear; Thechron; Theo-Dur; Thelair; Theon; Theophyl; Theograd; Theostat; Theovent; Unifyl; Uniphyl; Uniphyllin; Xanthium.; 1,3-Dimethyl-3,9-dihydro-purine-2,6-dione; 1,3-Dimethyl-3,9-dihydro-purine-2,6-dione; Theophylline; 1,3 dimethylxanthine; accurbron; aerobin; afonilum; afonilum retard; aquaphyllin; armophylline; bilordyl; bronchoretard; broncophyl; bronkodyl; bronkotabs; by 912; by912; constant t; cronasma; dicurin procaine; diffumal; diffumal 24; dilatrane; dilotrane; duraphyl; durofilin; elixicon; elixophyllin; elixophylline; euphylong; gtr 80; labid; labophylline; lasma; microcrystalline theophylline; monospan; neulin; neulin sa; nik 168 tx; nuelin; nuelin depot; nuelin sr; palaron; pediaphylline la; physpan; piridasmin retard; planphylline; pro vent; pulmidur; pulmo timelets; quibron t; respbid; rona phyllin; rona slophyllin; ronaphyllin; ronaslophyllin; slo bid; slo bid gyrocaps; slobid; slophyllin; sodip phyllin; solosin; solusin; somofillina; somofillina retardo; somophyllin; somophylline; somophylline crt; somophyllyn; spophyllin; spophyllin retard; sustaire; synophylate; talofilina; talotren; techniphylline; teobid; teofillina; teolin 300; teolong; teonova; teotard 350; theo 2; theo 24; theo bid; theo dur; theo sr; theobeads; theobid; theobron; theochron; theocin; theoclear; theocontin; theodur; theodur sprinkle; theofylline; theograd; theolair; theolair la; theolair plus; theolair retard; theolair sr; theolan; theolin retard; theolixer; theolong; theopec; theopek; theopexine; theophilline; theophyl; theophyllin; theophylline bruneau; theophylline hydrate; theophylline monohydrate; theophylline retard; theospan; theospirex; theospirex retard; theostan cr; theostat; theostat 300; theotard; theotrim; theovent; thiophyllin; thiophylline; uni dur; unicontin; unidur; unifyl; unilair; uniphyl; uniphyllin; uniphylline; vent retard; xantivent

Copyright © 2007 Elsevier Inc. All rights reserved.

Ovofar, Ask A Doctor About Ovofar - Doctor S Insight On Healthcaremagic, Ovofar

Ovofar

Hello Doctor, How Are You? I am fine Here. my suggested me MEPRATE and told me that i would be having periods before 10 days of taking the prescription and i did had periods on time when i came to USA, Had normal bleeding. Now i am having my period again right after 28 days, as you suggested i am taking OVOFAR 5mg tablets, But i am not having much bleeding currently. again i got my periouds after 13 days. Now my question is, do i need to continue taking OVOFAR tablets for couple months or would you be suggesting me something else. Thanks, Rajini

HI, WELCOME TO HCM,

ovafar is clomiphene which used to grow your egg. if you are planning for your baby you should consult your gynaecologist and take this tab. some time follicular study is needed to see whether you are ovulating or not. if there is no ovulation with clomiphene you may need.

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Lansoprazol Medlineplus Medicinas, Prazol

Lansoprazol

?Para cuales condiciones o enfermedades se prescribe este medicamento?

El lansoprazol con receta se usa para tratar la enfermedad por reflujo gastroesofagico (GERD, por sus siglas en ingles), una afeccion en la que el reflujo retrogrado del contenido gastrico provoca acidez estomacal y posibles lesiones del esofago (el conducto que une la garganta con el estomago). El lansoprazol con receta se usa para tratar los sintomas de la GERD, permitir que el esofago cicatrice y prevenir mas danos esofagicos. El lansoprazol con receta tambien se usa para tratar ulceras (lesiones en el revestimiento interno del estomago o del intestino), para evitar que se desarrollen mas ulceras en personas cuyas ulceras ya han cicatrizado y para disminuir el riesgo que tienen las personas que estan tomando medicamentos antiinflamatorios no esteroides (NSAID, por sus siglas en ingles) de desarrollar ulceras. El lansoprazol con receta tambien se usa para tratar las afecciones en donde el estomago produce demasiado acido, por ejemplo el sindrome de Zollinger-Ellison. El lansoprazol con receta tambien se usa en combinacion con otros medicamentos para tratar y prevenir ulceras gastricas ocasionadas por un determinado tipo de bacterias ( H. pylori ). El lansoprazol sin receta (venta libre) se usa para tratar la acidez estomacal frecuente (acidez estomacal que ocurre durante 2 o mas dias por semana). El lansoprazol pertenece a una clase de medicamentos llamados inhibidores de la bomba de protones. Actua disminuyendo la cantidad de acido que el estomago produce.

?Como se debe usar este medicamento?

La presentacion del lansoprazol con receta es en una capsula de liberacion retardada (libera el medicamento en el intestino para evitar que los acidos del estomago desintegren el medicamento) y en una tableta de disolucion en boca para administrar por via oral. La presentacion del lansoprazol sin receta es en una capsula de liberacion retardada (libera el medicamento en el intestino para evitar que los acidos del estomago desintegren el medicamento) para administrarse por via oral. Por lo general, el lansoprazol con receta se toma una vez al dia, antes de una comida. Cuando se toma en combinacion con otros medicamentos para eliminar H. pylori . el lansoprazol con receta se toma dos veces al dia (cada 12 horas) o tres veces al dia (cada 8 horas), antes de una comida, durante 10 a 14 dias. Por lo general, el lansoprazol sin receta se toma una vez al dia, por la manana, antes de comer, durante 14 dias. De ser necesario, se pueden repetir los tratamientos adicionales de 14 dias una vez cada 4 meses. Tome lansoprazol aproximadamente a la misma hora todos los dias. Siga atentamente las instrucciones del medicamento recetado y pidales a su medico o a su farmaceutico que le expliquen cualquier cosa que no entienda. Tome lansoprazol segun lo indicado. No aumente ni disminuya la dosis, ni la tome con mas frecuencia ni por mas tiempo que el indicado por su medico o el recomendado en el envase. Digale a su medico si usted ha tomado omeprazol sin receta por un periodo de tiempo mas largo que la indicada en el envase.

Trague las capsulas con receta enteras; no las parta, ni mastique ni triture. Si tiene dificultades para tragar las capsulas, puede abrir la capsula, espolvorear los granulos en una 1 cucharada de compota de manzana, pudin Ensure, queso cottage, yogurt o pure de peras, y tragar la mezcla inmediatamente sin masticar. Tambien puede abrir una capsula y verter el contenido en 2 onzas (60 mililitros) de jugo de naranja, jugo de manzana o jugo de tomate, mezclar un poco y tragar inmediatamente. Despues de tragar la mezcla, enjuague el vaso con mas jugo y bebalo inmediatamente. Luego, enjuague el vaso con jugo por segunda vez y beba el jugo para cerciorarse de quitar todo el medicamento del vaso.

Trague las capsulas sin receta enteras, con un vaso de agua. No las parta, ni mastique ni triture.

No rompa, corte ni mastique las tabletas de disolucion en boca. Coloque una tableta en la lengua y espere un minuto para que se disuelva. Despues de que la tableta se haya disuelto, traguela con o sin agua. Si no puede tragar la tableta, puede colocarla en una jeringa oral, extraiga 4 mL de agua para una tableta de 15 mg o 10 mL de agua para una tableta de 30 mg, agite la jeringa suavemente para disolver la tableta y coloque el contenido en la boca inmediatamente. Luego, extraiga con la jeringa 2 mL adicionales de agua, agite suavemente y coloquela en la boca. No trague la mezcla mas de 15 minutos despues de haber disuelto la tableta.

El contenido de la capsula y las tabletas de disolucion en boca pueden administrarse a traves de una sonda gastrica. Si tiene una sonda gastrica, consulte a su medico como debe tomar el medicamento. Siga estas instrucciones al pie de la letra.

No tome el lansoprazol sin receta para el alivio inmediato de los sintomas de acidez estomacal. Es posible que transcurran entre 1 y 4 dias para que experimente todos los beneficios del medicamento. Llame a su medico si los sintomas empeoran o no mejoran despues de 14 dias, o si los sintomas reaparecen en menos de 4 meses despues de concluir el tratamiento. No tome el lansoprazol sin receta durante mas de 14 dias, ni se administre tratamiento con omeprazol por su propia cuenta mas seguido que una vez cada 4 meses, sin consultar a su medico.

Continue tomando lansoprazol aunque se sienta bien. No deje de tomar lansoprazol con receta sin consultar a su medico. Si su afeccion no mejora o empeora, llame a su medico.

Pidales a su medico o a su farmaceutico una copia de la informacion del fabricante para el paciente.

?Que otro uso se le da a este medicamento?

Este medicamento puede recetarse para otros usos; pidales mas informacion a su medico o a su farmaceutico.

?Cuales son las precauciones especiales que debo seguir?

Antes de tomar lansoprazol,

Informe a su medico y a su farmaceutico si es alergico al lansoprazol, a algun otro medicamento o a alguno de los ingredientes de las capsulas de lansoprazol o de las tabletas de disolucion en boca. Pidales a su medico o a su farmaceutico una lista de los ingredientes.

Digales a su medico y a su farmaceutico que medicamentos con y sin receta, vitaminas, suplementos nutricionales y productos herbarios esta tomando o planea tomar. No olvide mencionar ninguno de los siguientes: ciertos antibioticos, incluyendo; ampicilina (Principen), anticoagulantes (diluyentes de la sangre), como warfarina (Coumadin), atazanavir (Reyataz), digoxina (Lanoxin), diureticos ("pildoras de agua"); suplementos de hierro, ketoconazol (Nizoral), metotrexato (Rheumatrex, Trexall), tacrolimus (Prograf) y teofilina (Theo-bid, TheoDur). Es posible que su medico deba cambiar las dosis de sus medicamentos o vigilarlo de cerca por si presentara efectos secundarios.

Informe a su medico si usted esta tomando rilpivirina (Edurant, en Complera, Odefsey). Su medico probablemente le dira que no tome lansoprazol si usted esta tomando este medicamento.

Si esta tomando sucralfato (Carafate), tomelo, al menos, 30 minutos despues de tomar lansoprazol.

Puede tomar antiacidos con el lansoprazol. Si tiene necesidad de un antiacido, pidale a su medico que le recomiende uno y le indique cuando y como tomarlo.

Informe a su medico si tiene o si alguna vez ha tenido un bajo nivel de magnesio en la sangre o enfermedad del higado.

Si planea tomar lansoprazol sin receta, primero informe a su medico si la acidez estomacal se ha prolongado durante 3 meses o mas, o si ha tenido alguno de estos sintomas: aturdimiento, sudoracion o mareos junto con la acidez estomacal; dolor en el pecho o dolor de hombros; falta de aire o sibilancia; dolor que se propaga a los brazos, al cuello o a los hombros; perdida de peso inexplicable; nauseas; vomitos, especialmente si son sanguinolentos; dolor de estomago; dificultad para tragar alimentos o dolor al tragar alimentos; o heces negras o sanguinolentas. Posiblemente tenga una afeccion mas grave, y eso no puede tratarse con medicamentos de venta sin receta.

Informe a su medico si esta embarazada, si planea quedar embarazada o si esta dando el pecho. Si queda embarazada mientras toma lansoprazol, llame a su medico.

Si tiene fenilcetonuria (PKU, por sus siglas en ingles, una afeccion hereditaria en la que se debe seguir una dieta especial para prevenir el retraso mental), debe saber que las tabletas de disolucion en boca pueden contener aspartame, lo que forma fenilalanina.

Si tiene 50 anos de edad o mas, preguntele a su medico si es predemte que usted tomae pantoprazol El riesgo de que usted puede desarrollar una forma grave de la diarrea causada por bacterias o que es posible que se fractura la muneca, la cadera o la columna vertebral puede ser mayor si usted es de una edad avanzada.

?Que dieta especial debo seguir mientras tomo este medicamento?

A menos que su medico le indique lo contrario, continue con su dieta normal.

?Que tengo que hacer si me olvido de tomar una dosis?

Si olvida tomar una dosis, tomela en cuanto se acuerde. No obstante, si ya casi es hora de la dosis siguiente, deje pasar la dosis que olvido y continue con su horario de medicacion normal. No tome una dosis doble para compensar la que olvido.

?Cuales son los efectos secundarios que podria provocar este medicamento?

El lansoprazol puede provocar efectos secundarios. Informe a su medico si alguno de estos sintomas es intenso o no desaparece:

Algunos efectos secundarios pueden ser graves. Si tiene alguno de los siguientes sintomas, llame a su medico de inmediato:

sarpullido

ampollas o descamacion de la piel

urticaria

inflamacion de los ojos, la cara, los labios, la boca, la lengua o la garganta

dificultad para respirar o tragar

ronquera

latidos del corazon irregulares, rapidos, o fuertes

cansancio excesivo

mareos

sensacion de mareo

espasmos musculares

temblor incontrolable de una parte del cuerpo

convulsiones

diarrea grave con heces acuosas

dolor de estomago

fiebre

El lansoprazol puede provocar otros efectos secundarios. Llame a su medico si tiene algun problema inusual mientras esta tomando el medicamento.

Las personas que estan tomando inhibidores de la bomba de protones, como lansoprazol, pueden tener mayores probabilidades de fracturas en las munecas, las caderas o la columna vertebral que las personas que no toman uno de estos medicamentos. El mayor riesgo lo tienen las personas que toman dosis altas de uno de estos medicamentos o que los toman durante un ano o mas. Hable con su medico sobre el riesgo de tomar lansoprazol.

Si desarrolla un efecto secundario grave, usted o su doctor puede enviar un informe al programa de divulgacion de efectos adversos 'MedWatch' de la Administracion de Alimentos y Medicamentos (FDA, por su sigla en ingles) en la pagina de Internet (http://www. fda. gov/Safety/MedWatch ) o por telefono al 1-800-332-1088.

?Como debo almacenar o desechar este medicamento?

Mantenga este medicamento en su envase original, bien cerrado y fuera del alcance de los ninos. Almacenelo a temperatura ambiente y en un lugar alejado del exceso de calor y humedad (nunca en el cuarto de bano). Deseche todos los medicamentos que esten vencidos o que ya no necesite. Preguntele a su farmaceutico cual es la manera adecuada de desechar sus medicamentos.

?Que debo hacer en caso de una sobredosis?

Buy Deprevex Online, Order No Prescription Micardis, Deprevex

Buy Deprevex (Micardis) without Prescription

DEPREVEX (MICARDIS) INDICATIONS

Deprevex is used for treating high blood pressure alone or with other medicines. It is also used to reduce the risk of heart attack, stroke, or death due to heart problems in certain patients. Deprevex is an angiotensin II receptor blocker (ARB). It works by relaxing blood vessels, which helps to lower blood pressure.

DEPREVEX (MICARDIS) INSTRUCTIONS

Use Deprevex as directed by your doctor.

Take Deprevex by mouth with or without food.

Do not remove the tablet from the blister seal until you are ready to take your dose.

Take Deprevex on a regular schedule to get the most benefit from it. Taking Deprevex at the same time each day will help you remember to take it.

Continue to take Deprevex even if you feel well. Do not miss any dose.

If you miss a dose of Deprevex, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Deprevex.

DEPREVEX (MICARDIS) STORAGE

Store Deprevex at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Deprevex out of the reach of children and away from pets.

DEPREVEX (MICARDIS) MORE INFO:

Active Ingredient: Telmisartan.

Do NOT use Deprevex if:

you are allergic to any ingredient in Deprevex

you are in your second or third trimester of pregnancy.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Deprevex. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you are able to become pregnant

if you have a history of angioedema (eg, swelling of the hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; hoarseness), including angioedema caused by treatment with an angiotensin-converting enzyme (ACE) inhibitor (eg, lisinopril)

if you have a history of heart problems (eg, heart failure), blood vessel problems, blood flow problems, liver or kidney problems, gallbladder problems, or diabetes

if you have a history of stroke or recent heart attack

if you are dehydrated or have low blood volume

if you have electrolyte problems (eg, high blood potassium levels, low blood sodium levels) or are on a low-salt (sodium) diet

if you are on dialysis or are scheduled to have major surgery

if you take another medicine for blood pressure or heart problems.

Some medicines may interact with Deprevex. Tell your health care provider if you are taking any other medicines, especially any of the following:

Diuretics (eg, furosemide, hydrochlorothiazide) because the risk of low blood pressure may be increased

Potassium-sparing diuretics (eg, spironolactone, triamterene) or potassium supplements because the risk of high blood potassium levels may be increased

ACE inhibitors (eg, lisinopril, ramipril) because the risk of kidney problems may be increased

Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, celecoxib, indomethacin) because they may decrease Deprevex's effectiveness

Digoxin or lithium because the risk of their side effects may be increased by Deprevex.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Deprevex may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Deprevex may cause dizziness, lightheadedness, or fainting. These effects may be worse if you take it with alcohol or certain medicines. Use Deprevex with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Deprevex may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.

Deprevex may cause a serious side effect called angioedema. Contact your doctor at once if you develop swelling of the hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; or hoarseness.

Deprevex may not work as well in black patients. Discuss any questions or concerns with your doctor.

Dehydration, excessive sweating, vomiting, or diarrhea may increase the risk of low blood pressure. Contact your health care provider at once if any of these occur.

Check with your doctor before you use a salt substitute or a product that has potassium in it.

Tell your doctor or dentist that you take Deprevex before you receive any medical or dental care, emergency care, or surgery.

Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.

If you have high blood pressure, do not use nonprescription products that contain stimulants. These products may include diet pills or cold medicines. Contact your doctor if you have any questions or concerns.

Lab tests, including blood pressure, blood electrolyte levels, and heart, kidney, or liver function, may be performed while you use Deprevex. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Deprevex should be used with extreme caution in children; safety and effectiveness in children have not been confirmed.

Pregnancy and breast-feeding: Deprevex may cause birth defects or fetal death if you take it while you are pregnant. If you think you may be pregnant, contact your doctor right away. It is not known if Deprevex is found in breast milk. Do not breastfeed while taking Deprevex.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Back pain; diarrhea; dizziness; sinus pain or congestion; sore throat; upper respiratory tract infection.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); change in the amount of urine produced or painful urination; chest pain; difficulty swallowing; fast, slow, or irregular heartbeat; fever, chills, or persistent sore throat; increased or excessive sweating; muscle pain or cramps; severe or persistent vomiting or diarrhea; severe or persistent weakness; shortness of breath; swelling of the arms or legs; symptoms of low blood pressure (eg, fainting, lightheadedness, severe dizziness); tendon or joint pain.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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See Also

Quincef, Quincef

Quincef

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Quince

Photography Credit: Elise Bauer

Have you ever eaten a quince. The first time I had quince jelly I couldn’t believe how such a peculiar looking hard yellow fruit (like a slightly squashed pear) could yield such a fragrant, delicate, pink jelly. Quinces cannot be eaten raw, they are too tart. But the tannins that cause the tartness in the raw fruit mellow when cooked (and turn the fruit pink). Cooked, a quince transforms into something lovely.

Quinces used to be more popular than they are today; you often can find an odd small quince tree growing in the yard of an old house. But people don’t can as much as they used to and unless you’ve actually had something made with quince, you don’t know what you’re missing. Here are some ideas for what you can make with them:

Quince Recipes from More Food Blogs

Rosey Poached Quince – Cookbook author and dessert connoisseur David Lebovitz reminds us to be careful when cutting these hard fruit.

Quince Jam – from Fethiye of YogurtLand.

Quince and Blueberry Crumble Cake – by Haalo of Cook (almost) Anything at Least Once.

Slow Cooked Whole Quince – Brett of In Praise of Sardines explains why the quince turn so red when they are cooked.

Quince-Raisin Tarte Tatin – from Christine of Christine Cooks.

Quince Tarte Tatin from The Serendipitous Chef.

Sugared Quince Paste – Michelle of an Endless Banquet uses the Chez Panisse fruit cookbook.

Paste of Quinces, or Pate de Coings – Carolyn of 18thC Cuisine pulls out a recipe from 1716 Paris.

Membrillo to pair with Manchego cheese from Nicky of Delicious Days.

Dulce de Membrillo – Melissa of The Traveler’s Lunchbox cooking from “The Basque Table” cookbook by Teresa Barrenechea.

They can be eaten raw, and commonly are in the South, by grating (with a cheese grater) and soaking in salt water.

The Portuguese used quince jam in their discovery voyages, they call it marmelade, not to confused with American marmelade.

Here is another idea for using quince raw – Quince Salad – delicious served with any fish dish especially, but goes well as a side dish to other meats as well. First mix 1 cup of lemon juice with 1/2 cup of sugar and 1/2 teaspoon salt. Stir well until sugar is all dissolved. Keep aside. For 4 servings take 2 – 3 medium sized quinces. Wash and dry, cut any spots away. With skin on and using the course side, grate the quince all around till you reach the core. into a dish with a close fitting top, ie an plastic ice cream container. when done pour the lemon juice mixture over the grated quince, close the lid tightly and shake container well for the lemonjuice to mix well with the grated quince. Place in refrigerator for a couple of hours for flavours to mix and develop until ready to serve. Unfortunately it does not keep long before turning brown, but this fresh tasting salad is worth the effort :).

Hi Quinces CAN be eaten raw, I do so all the time (been doing it since I was a kid). I find them delicious and juicy, and they contain very good levels of vitamin C – specially useful in winter times. By eating them raw you get the most of their antioxidants, their astringents compounds protect the colon’s mucous membrane from inflammatory bowl disease, reduce body weight and cholesterol. They are also a good source of fibre, copper, iron, potassium, magnesium and vitamins (B-6, thiamine, riboflavin). It has anti-allergenic and anti-inflammatory properties.

Not bad for a under-estimated old fruit. Give it a try if you dare.

I spent 3 years in France as a child, grades 4 to 6, and quince trees grew in almost every yard. We had 6 trees in our garden. We never used them except for jam. I now live in Michigan and planted a quince tree in my orchard 3 years ago. Had only 2 fruits last year the second year since planting, but this year I got 1/2 bushel of fruits. At the moment I have 8 fruits poaching on the stove. First attempt at recipie other than jam. Anxious to see how they turn out. I did try a slice of raw quince and did not find it it to be overly sour or tart. My tree was called a Russian quince and it was described as having edible raw fruit. Iam also a diabetic and really happy to see Herman’s recipie for pie using Splenda, I am certain one is in my future.

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WHAT IS ALKALINE WATER

Your body’s natural pH level is 7.36, which it works hard to maintain. Unfortunately, the highly processed, unhealthy diets of today tend to be more acidic on the pH scale, which can lead to illness and disease as the body uses its resources to maintain its balance. Your pH level impacts all of your body's cells, tissues, glands, organs, and organ systems–that's EVERYTHING in your body. Increasing your alkalinity to 7.36 alleviates stress on your organ systems right down to the cells, helping your body fight off illness and disease. Many people are choosing alkaline water to support the body in maintaining optimal pH levels, which also promotes optimal health.

SHOP SANTEVIA

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THE SANTEVIA STORY

Santevia Mineralized Alkaline Water Systems restore tap water to its natural, great tasting and healthiest state. They add nourishing minerals and restore alkalinity to your water, which helps maintain your alkaline body balance for optimal health.

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Ryback - Pro Wrestling, Ryebact

Ryback

Debut

Ryan Reeves (November 10, 1981 ) is an American professional wrestler. He is best known for his time in WWE. where he performed under the ring name Ryback and is a former WWE Intercontinental Champion. After being one of the eight finalists on WWE Tough Enough 4 . he later signed a developmental contract with World Wrestling Entertainment and wrestled in its developmental territories Deep South Wrestling. Ohio Valley Wrestling. and Florida Championship Wrestling. He also participated in the first season of NXT in early 2010 under the ring name Skip Sheffield . Reeves headlined four pay-per-view events for WWE in the early 2010s, three of those for the WWE Championship.

Contents

Early life

Reeves started watching wrestling at the age of 8 and was allowed to ring the bell at a live World Wrestling Federation event. Wanting to become a professional wrestler, Reeves began weight lifting at 12 years old. He was nicknamed "Silverback" as a teenager, after a childhood friend joked that he resembled a Gorilla, and later adopted it as a part of his ring name. Reeves excelled at baseball and football while attending Western High School and Palo Verde High School. He also played college baseball during his freshman year at the Community College of Southern Nevada, but broke his leg and ended up missing two seasons. Reeves attended the University of Nevada, Las Vegas and entered in its fitness management program.

Professional wrestling career

Tough Enough (2004)

Reeves spent the next two years concentrating on training to enter professional wrestling. He also attended University of Nevada, Las Vegas, majoring in fitness management, while working part-time at the Monte Carlo Hotel and Casino. Reeves sent a brief one minute videotape of himself to become a contestant on $1,000,000 Tough Enough and was invited to Venice Beach with 49 others. During the first week of training, Reeves suffered from bronchitis and a rib injury. He eventually became one of the eight finalists to appear on SmackDown! and the last to be voted off. Even though he did not win the competition, Reeves impressed WWE officials enough for them to sign him to a developmental contract. He spent time healing from his injuries in Las Vegas before heading to Atlanta, Georgia in March 2005.

Ohio Valley Wrestling

Debut (2005–2006)

After training in DSW for most of 2005 and early 2006, Reeves was transferred over to Ohio Valley Wrestling in early March. He defeated Kasey James. Pat Buck. Da Beast and Nick Nemeth in dark matches over the next two months and, with Mikey Batts. defeated the teams of Billy Kryptonite and Russell Simpson, and Jack Bull and Vic Devine.

In July 2006, Reeves was suspended for 30 days due to failing a drug test as part of WWE's Wellness Program. According to Reeves, he had been taking several over the counter bodybuilding supplements, one of which inadvertently caused a false reading. The supplements he was using were later taken off the market due to this effect and, although his suspension remained in place, Reeves eventually returned to the roster after passing a second test. His case was later featured on the CNN documentary Death Grip: Inside Pro Wrestling .

High Dosage (2006–2007)

After his previous 30 day suspension, Reeves returned while sporting bleached hair. In September 2006, Reeves began teaming with Jon Bolen. and together the team became known as High Dosage. Scoring early victories against teams such as Los Locos (Aaron Lamata and Low Rider ) and Gothic Mayhem (Johnny Punch and Pat Buck), they began feuding with the then newly formed team of Eddie Craven, Mike Kruel and "The Bad Seed" Shawn Osborne.

The two did not fare well against the trio losing both tag team and single matches to them during the next few weeks. On October 18. he and Bolen also lost to them in a handicap match. Things soon changed however when High Dosage beat Eddie Craven and Mike Kruel a month later. As a result of their victory, they were allowed five minutes alone with Shawn Osbourne but he was able to escape with the help of Craven and Kruel. Although continuing to face their rivals throughout the year, High Dosage also won matches against Los Locos and Bad Company defeating them later in a Handicap Coal Miner's Glove on a Pole match on November 29. On December 9, High Dosage teamed with Seth Skyfire and lost to Craven, Kruel and Milena Roucka. Reeves also took part in a four-way Elimination Christmas Present match with Kruel four days later. The participants included Justin LaRoche and Charles Evans, T. J. Dalton and Steve Lewington. and Seth Skyfire and Paul Burchill who eventually won the match.

On January 6, 2007, High Dosage lost to Justin LaRouche and Charles Evans. They also lost to the Tag Team Champions Cody Runnels and Shawn Spears four days later. This was their last match together as Reeves was officially released from his contract less than two weeks later. Despite having been released from his developmental contract, Reeves returned to OVW on November 14 and teamed with Pat Buck in a losing effort to Colt Cabana and Shawn Spears for the Tag Team Championship.

Heavyweight Champion and departure (2008)

After over a year's absence from OVW, Reeves returned to OVW under the ring name Ryback and under a new Terminator gimmick. In his first match since returning, he managed to win the Heavyweight Championship on October 15. 2008 by defeating Anthony Bravado. After wrestling Bravado to a double count-out on October 22 and thus retaining the title, he ultimately lost the title to Bravado on October 29. Soon after the title loss, Reeves was then re-signed to a developmental contract with World Wrestling Entertainment. To explain his departure, Ryback lost a Loser Leaves OVW match to Bravado on December 17.

World Wrestling Entertainment / WWE

Florida Championship Wrestling (2008–2010)

On December 16, 2008, Reeves, under his Ryback ring name and character, made his in-ring debut in Florida Championship Wrestling. losing a tag match with Jon Cutler against Kris Logan and Taylor Rotunda. Ryback soon formed a tag team with Sheamus O'Shaunessy and the duo unsuccessfully challenged for the Florida Tag Team Championship on a few occasions until O'Shaunessy was called up to the main roster. After the Ryback character was scrapped, Reeves made his FCW redebut on October 25 under the ring name Skip Sheffield, a cowboy gimmick, where he defeated Jimmy Uso.

NXT and The Nexus (2010)

On February 16, 2010 during the final episode of ECW . Sheffield was announced as one of eight FCW wrestlers, called "rookies", to take part in the first season of WWE's new NXT show. Although Montel Vontavious Porter was originally to be his mentor, or "pro", he was later replaced by William Regal. Sheffield made his NXT in-ring debut on the March 2 episode, where he teamed with Regal to lose to Matt Hardy and Justin Gabriel. On the April 27 NXT . Sheffield picked up his first victory with a win over Daniel Bryan. However, Sheffield was eliminated by the Pros on May 11, despite an earlier win over Darren Young. in the first NXT elimination poll. He was one of three eliminations that same night, behind Bryan and Michael Tarver. and said he would be back.

On the June 7 episode of Raw . Sheffield along with the other NXT season one rookies, interfered in the main event match between John Cena and CM Punk. attacking both competitors as well as the announcing team before dismantling the ring area and surrounding equipment. On the June 14 Raw . the rookies attacked General Manager Bret Hart. when he refused to give them contracts. The following week on Raw . Vince McMahon fired Hart and announced the hiring of a new General Manager, who had signed all seven season one NXT rookies to contracts. The following week, the group was named the Nexus. On the July 12 Raw . The Nexus (without Darren Young) competed in their first match together, defeating John Cena in a six-on-one handicap match. The feud continued at SummerSlam. where Team WWE fought the Nexus in a seven-on-seven elimination tag team match. Sheffield eliminated both John Morrison and R-Truth from the match before becoming the third member of the Nexus to be eliminated. Ultimately, the Nexus lost the match. On August 18, during a live event in Honolulu. Hawaii. Reeves broke his ankle in a tag team match with David Otunga against The Hart Dynasty.

Reeves then underwent extensive surgery after breaking his ankle, with a third surgery being his last. Reeves returned from injury at a Raw house show on December 3, 2011.

Feed Me More (2012–2013)

Reeves, now sporting a beard and a new attire, returned to television on the April 6, 2012, episode of SmackDown . under his Ryback ring name and as a face. Over the following weeks, he would squash jobbers. as well as more established wrestlers like Heath Slater and Derrick Bateman. At Extreme Rules. he made his pay-per-view debut as a singles competitor when he defeated two more jobbers (Aaron Relic and Jay Hatton) in under two minutes. At Over the Limit. Ryback defeated Camacho in another squash match. On July 3 during The Great American Bash episode of SmackDown . he defeated Curt Hawkins to continue his winning streak. After defeating Tyler Reks the following week on SmackDown . Ryback defeated both Hawkins and Reks in a handicap match at Money in the Bank and again during Ryback's Raw redebut on the August 6 episode. On the July 27 SmackDown . Ryback began his first feud since returning to the main roster against Jinder Mahal. after Mahal lost via countout instead of continuing to wrestle. Ryback faced Mahal in a rematch on August 3 SmackDown . but won via disqualification after Mahal struck him with a microphone. On the August 24 SmackDown . Ryback finally defeated Mahal via pinfall and did so again on the September 3 Raw .

After defeating the Intercontinental Champion The Miz in a non-title match on the September 24 Raw . Ryback confronted the WWE Champion CM Punk at the end of the show after Punk attacked Mick Foley. On the next two episodes of Raw . Ryback again confronted Punk after he threatened Jim Ross during an "Appreciation Night" segment honoring Ross, and after he brawled with WWE Chairman Vince McMahon. McMahon then declared Punk must choose to defend the WWE Championship against Ryback or John Cena at Hell in a Cell. and if he refused, McMahon would choose for him. On the October 15 Raw . Cena willingly backed out of challenging Punk in favor of supporting Ryback as Punk's opponent at Hell in a Cell. On October 28 at the pay-per-view, Ryback's thirty-eight match undefeated streak was broken by Punk due to a low blow and fast count by referee Brad Maddox. After the match, Ryback attacked Maddox and hit Punk with the Shell Shocked on top of the cell. The following night on Raw . Ryback was named as the final member of Mick Foley's team to face CM Punk's team at Survivor Series. The next week, Ryback and John Cena were booked in a Triple Threat match for Punk's WWE Championship at the pay-per-view instead. On the November 13 Raw . Ryback gained revenge against Brad Maddox by squashing him in a match before throwing him into an ambulance, thus denying Maddox a chance at joining the WWE roster as a wrestler. On November 18 at Survivor Series, Ryback was unsuccessful in the championship match after he was attacked by Seth Rollins. Dean Ambrose. and Roman Reigns. who powerbombed him through the announce table, allowing Punk to pin Cena and retain the title. The following night on Raw . Ryback was again attacked by Rollins, Ambrose, and Reigns, now collectively known as The Shield. before they again powerbombed him through the announce table after Ryback attempted to attack Punk while he was celebrating his year-long reign as WWE Champion. On the November 26 Raw . Ryback demanded another opportunity at the WWE Championship, with Vickie Guerrero finally relenting and giving him the title match at TLC: Tables, Ladders & Chairs. Later that night, Ryback attacked Punk with a ladder and chair before finally powerbombing him through a table. Punk suffered a legitimate knee injury during to the attack, and the title match was postponed. Ryback was instead paired with the WWE Tag Team Champions Team Hell No (Daniel Bryan and Kane ) to compete against The Shield in a six-man Tables, Ladders, and Chairs match. where The Shield was victorious. The following night on Raw during the 2012 Slammy Awards. Ryback won three Slammy Awards for Newcomer of the Year, Crowd Chant of the Year, and #Trending Now. On the January 7, 2013 Raw . Ryback again failed to capture the WWE Championship from Punk in a Tables, Ladders, and Chairs match, after The Shield interfered and powerbombed Ryback through a table on top of the ring steps.

On January 27 at the Royal Rumble. Ryback entered the Royal Rumble match as the thirtieth and final entrant and eliminated five superstars before being the last man eliminated by John Cena. Ryback would then resume his rivalry with The Shield on the February 4 Raw . when he teamed up with John Cena and Sheamus to attack the stable. This culminated in a six-man tag team match on February 17 at Elimination Chamber. where The Shield emerged victorious when Seth Rollins pinned Ryback for the win. The following night on Raw . Ryback and Sheamus teamed up with Chris Jericho to face The Shield in a rematch, but were again defeated. Ryback then began a feud with Mark Henry after several non-verbal confrontations led to them attacking Drew McIntyre with their finishing moves in an attempt to one-up each other. On the March 15 SmackDown . Ryback defeated Henry via disqualification following interference from The Shield. Afterwards, Henry delivered the World's Strongest Slam to Ryback three times in a row. Ryback and Henry competed in a Bench Press Challenge on the March 29 SmackDown . where Ryback tied Henry at 53 reps after Henry choked him with the weight. On April 7 at WrestleMania 29. Ryback was defeated by Henry in a singles match.

RybAxel (2013–2014)

The following night on Raw . Ryback saved WWE Champion John Cena from a post-match assault by Mark Henry before attacking Cena himself. The following week on Raw . Ryback explained his attack on Cena as stepping out from his shadow and getting revenge for Cena not having his back against The Shield; Ryback got a measure of revenge later that night, by allowing the Shield to attack Cena. After becoming the number one contender to the WWE Championship, Ryback continued his feud with Cena by attacking him on several occasions while also having confrontations with The Shield. Ryback received his title opportunity in a Last Man Standing match on May 19 at Extreme Rules. however, the match ended in a no-contest after Ryback rammed Cena and himself into the electric backdrop at the top of the ramp. The following night on Raw . Ryback entered the arena in an ambulance and challenged Cena to an ambulance match for the WWE Championship at the first-ever Payback pay-per-view. The following week on Raw . Cena accepted Ryback's challenge, but announced their match would instead be a 3 Stages of Hell match ; the first fall a lumberjack match. the second a tables match and the third an ambulance match. At the pay-per-view on June 16, Ryback won the lumberjack match, but went on to lose both the tables and ambulance matches and his shot at the WWE Championship. Ryback then began feuding with Chris Jericho, which led to a singles match on July 14 at Money in the Bank. where Ryback emerged victorious.

In August, Ryback debuted a new gimmick, where he began bullying various backstage workers. Also as part of the gimmick, Ryback would back away from fighting opponents of equal size and taking advantage of smaller and vulnerable opponents.

On September 15 at Night of Champions. Ryback aligned himself with Paul Heyman after helping him defeat CM Punk. Despite being a bully himself, Ryback claimed he hated bullies and vowed to stop CM Punk and anyone else who acted as such. On October 6 at WWE Battleground. Ryback was defeated by Punk in a singles match following a low blow from Punk. On October 27 at Hell in a Cell. Ryback and Heyman were defeated by Punk in a 2-on-1 handicap Hell in a Cell match. The feud ended the following night on Raw . when Punk defeated Ryback in a Street Fight match after forcing him to submit to the Anaconda Vise . marking Ryback's first ever submission loss. On the November 11 episode of Raw . the alliance between Ryback and Heyman came to an end when Heyman verbally berated him.

On November 24 at Survivor Series. Ryback was defeated by the returning Mark Henry after he answered Ryback's open challenge. Ryback then began a tag team with fellow former Paul Heyman Guy Curtis Axel collectively labelled as "Rybaxel", and on the December 6 episode of SmackDown . they defeated WWE Tag Team Champions Cody Rhodes and Goldust in a non title match to earn a shot at the titles. Rybaxel received their title shot on December 15 at TLC: Tables, Ladders & Chairs. but were defeated by Cody Rhodes and Goldust in a four-way elimination match, also involving Big Show /Rey Mysterio and The Real Americans (Antonio Cesaro and Jack Swagger ). RybAxel received another shot at the WWE Tag Team Championship on April 6, 2014, at the WrestleMania XXX pre-show, but were defeated by defending champions The Usos in a fatal four-way elimination match, which also included Los Matadores and The Real Americans. At Payback. Rybaxel defeated Cody Rhodes and Goldust in a tag team match. At Money in the Bank. RybAxel lost to Goldust and Stardust. On July 2, it was announced that Ryback and Axel would be competing for the vacant WWE Intercontinental Championship in an over the top battle royal at Battleground. but neither Ryback or Axel managed to win. On August 26, 2014, Ryback underwent hernia surgery.

Return, and Intercontinental Championship (2014–2016)

Ryback returned on the October 27 edition of Raw . as a face. defeating Bo Dallas. On the November 10 edition of Raw . Ryback joined Team Authority by attacking Cena, thus teasing a heel turn. However, this was later proven to be a ruse when he attacked Team Authority and defected to Team Cena. Ryback was eliminated by Rusev, but Team Cena won the match, putting The Authority out of power. Ryback defeated Team Authority member Kane in a Chairs match at TLC. After Seth Rollins coaxed Cena to bring The Authority back into power, Ryback, along with Erick Rowan and Dolph Ziggler, were (kayfabe) fired by Triple H on the January 5 episode of Raw as punishment for insubordination, but they were re-hired after Cena defeated Rollins, Kane and Big Show in a handicap match on the January 19 episode of Raw. On the January 22 episode of SmackDown, Ryback defeated Rusev via count-out to earn a spot in the Royal Rumble match, where he was eliminated by Big Show and Kane. At Fastlane, he teamed with Rowan and Ziggler in a six-man tag team match against Rollins, Big Show and Kane, but lost. Ryback participated in the Andre the Giant Memorial Battle Royal at WrestleMania 31, but was eliminated by the eventual winner, Big Show. On the Raw following Extreme Rules. Ryback was attacked by Bray Wyatt (who sent a series of mysterious promos aimed at Ryback weeks prior), leading to a match at Payback, which Ryback lost.

At Elimination Chamber. Ryback won the vacant WWE Intercontinental Championship. his first title in WWE, by defeating Sheamus. Dolph Ziggler. King Barrett. Mark Henry and R-Truth in an Elimination Chamber match. The following night, before Ryback was scheduled to make his first title defense against The Miz, Big Show attacked Miz and confronted Ryback, starting a feud between the two. At Money in the Bank. Big Show defeated Ryback by disqualification after Miz attacked him; Ryback retained the title as a result. It was later announced that that Ryback would defend the title against Big Show and Miz in a triple threat match at Battleground. However, Ryback would suffer an injury, cancelling the match.

Ryback retained against Big Show and The Miz at Summerslam, but would lose the title to Kevin Owens at Night Of Champions. Ryback would unsuccessfully challenge Owens in a rematch at Hell in a Cell. Ryback would enter a Traditional Survivor Series Elimination Match, teaming with the Lucha Dragons and the Usos against The New Day and Sheamus and King Barrett. Ryback, Jey Uso, and Kalisto would become the remaining survivors. Ryback would reenter a feud with Rusev, whom he lost to at TLC.

Ryback would enter the 2016 Royal Rumble Match for the WWE World Heavyweight Championship at #9, but was eliminated. Ryback would align with Big Show and Kane against The Wyatt Family at Fastlane, which the Titans won. However, the next night in a rematch, The Titans lost when Ryback left Big Show and Kane, turning heel. Ryback feuded with Kalisto over the United States Championship, which Ryback was unsuccessful twice at Wrestlemania 32 and WWE Payback.

On August 5, 2016, Reeves confirmed on his Instagram that he and WWE had parted ways.

Independent circuit (2016–present)

Immediately after announcing his WWE departure, Reeves announced via his Instagram that he will be taking independent bookings. It was announced that Reeves would be wrestling at WrestlePro on October 14, 2016, under the ring name The Big Guy .

Trivia

The character of Ryback has been often compared to the character of Goldberg.

Ryback is the first person to be Triple Powerbombed by The Shield.

Ryback's name is a mix of his real name Ryan and Silverback.

In wrestling

Championships and accomplishments

Noroxin - Man S Health, Uritrat

Product Description Common use Noroxin is quinolone antibiotic used for treatment of urinary tract such as pyelonephritis, cystitis, urethritis), genitals (prostatitis, cervicitis, endometritis), gastrointestinal tract (salmonellosis, shigellosis), uncomplicated gonorrhea. Mechanism of its action consists in inhibition of DNA gyrase leading to destabilization of the bacterial DNA and death of the susceptible bacteria. Noroxin is active against Staphylococcus spp. (including Staphylococcus aureus), Neisseria spp. E. coli, Citrobacter spp. Klebsiella spp. Proteus spp. Salmonella spp. Enterobacter spp. Hafnia, Shigella spp. Mycobacterium tuberculosis, Vibrio cholerae, Haemophilus influenzae, Chlamydia spp. Mycoplasma spp. and some others. Medication is active for 12 hours.

Dosage and directions To treat infections of urinary tract, take 400 mg of Noroxin two times a day during 7-10 days, to treat non-complicated cystitis treatment continues 3-7 days, and in patients with recurrent chronic infection of urinary tract it is up to 12 weeks. For prostatitis the recommended daily dose is 800 mg, divided into 2 doses, for four weeks. Usual single recommended dose to treat gonorrhea is 800 milligrams for 1 day. The maximal daily dose is 800 milligrams. Take with a full glass of water two hours after a meal or one hour before it. Drink plenty of water while taking Noroxin to avoid formation of needle-shaped crystals in your urine. The elderly and people with kidney problems may need to use a reduced dosage or have their kidney function monitored. Take exactly as prescribed by your doctor. Do not start or stop treatment without your doctor's permission.

Precautions In elderly and patients with kidney impairment, kidney function monitoring is required on a regular basis. This medication may cause photosensibilization, avoid direct sun rays during treatment. Limit consummation of alcoholic beverages as they may worsen such side effects as dizziness, drowsiness and others which may affect your ability to operate machinery and driving.

Contraindications This medication cannot be administered in patients with hypersensitivity to Noroxin, pregnant and breastfeeding women, children under 18 y. o. individuals with glucose-6-phosphate dehydrogenase deficiency. Caution is required when Noroxin is administered in individuals with cerebral arteriosclerosis, cerebrovascular dysfunctions, epilepsy, epileptic syndrome, Myasthenia gravis, kidney or liver failure.

Possible side effect The most common side effects include: weakness, headache, drowsiness, dizziness, nausea, stomach upset. Rare but serious side effects are: tremor and sun sensitivity, seizures, mental/mood changes, sore throat/fever, vision changes, hearing loss, change in amount or appearance of urine, jaundice, fainting, changes in heartbeat, easy bruising or bleeding, numbness or tingling of extremities. Tendon damage and weakening of muscles is rare but possible. Stop exercising and claim prompt medical attention if you experience pain in your joint or tendon. In case of pseudomembranous colitis (persistent diarrhea, abdominal or stomach pain/cramping, blood/mucus in your stool) which may develop even a few weeks after the treatment was discontinued, do not use anti-diarrhea products or narcotic pain medications. Tell your doctor immediately about your condition. Prolonged or repeated used of Noroxin may cause oral thrush or a new vaginal yeast infection with such symptoms as: white patches in the mouth, a change in vaginal discharge. Inform your doctor immediately if you experience allergic reaction (severe dizziness, rash, itching, swelling, trouble breathing).

Drug interaction Theophylline dose should be decreased while on Noroxin. Noroxin increases the blood concentration of indirect anticoagulants, cyclosporine, decreases effects of nitrofurans. Antacids which contain ions of Al and Mg, medications which contain Fe, Zn2+, sucralfate should be taken at least with four hour interval with Noroxin. Concomitant intake with the medicines decreasing epileptic threshold may lead to epileptic attacks. Dangerous sudden drop in blood pressure or changes in heart rhythm are possible when Noroxin is concomitantly used with the drugs for blood pressure or affecting the heart rhythm. Inform your doctor about all prescribed and over-the-counter medications and herbal products you are taking.

Missed dose If you miss a dose, take it as soon as you remember unless it is almost time of your next dose. If it is near the time of the next dose, skip the missed dose and return dosing schedule. Do not double the dose to make up the missed dose.

Overdose Symptoms of overdose include: dizziness, nausea, vomiting, drowsiness, "cold" sweating, puffy face without major changes in hemodynamic indices.

Storage Store at room temperature in a tight container, away from moisture and humidity.

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Nyquil Oral Uses, Side Effects, Interactions, Pictures, Warnings - Dosing, Zoprazide

NyQuil

GENERIC NAME(S): DEXTROMETHORPHAN/PSEUDOEPHRINE HCL/ACETAMINOPHEN/DOXYLAMINE

Warnings

One ingredient in this product is acetaminophen. Taking too much acetaminophen may cause serious (possibly fatal) liver disease. Adults should not take more than 4000 milligrams (4 grams) of acetaminophen a day. People with liver problems and children should take less acetaminophen. Ask your doctor or pharmacist how much acetaminophen is safe to take.

Do not use with any other drug containing acetaminophen without asking your doctor or pharmacist first. Acetaminophen is in many nonprescription and prescription medications (such as pain/fever drugs or cough - and-cold products). Check the labels on all your medicines to see if they contain acetaminophen, and ask your pharmacist if you are unsure.

Get medical help right away if you take too much acetaminophen (overdose), even if you feel well. Overdose symptoms may include nausea. vomiting. loss of appetite, sweating. stomach /abdominal pain. extreme tiredness, yellowing eyes /skin. and dark urine.

Daily alcohol use, especially when combined with acetaminophen, may damage your liver. Avoid alcohol.

Uses

This combination medication is used to temporarily treat symptoms caused by the common cold. flu. allergies. or other breathing illnesses (such as sinusitis. bronchitis ). Dextromethorphan is a cough suppressant that affects a certain part of the brain. reducing the urge to cough. Decongestants help relieve stuffy nose and ear congestion symptoms. Acetaminophen (APAP) is a non-aspirin pain reliever and fever reducer. Antihistamines help relieve watery eyes. itchy eyes /nose/throat, runny nose. and sneezing .

This medication is not usually used for ongoing coughs from smoking. asthma. or other long-term breathing problems (such as emphysema ), or for coughs with a lot of mucus, unless directed by your doctor.

Cough-and-cold products have not been shown to be safe or effective in children younger than 6 years. Therefore, do not use this product to treat cold symptoms in children younger than 6 years unless specifically directed by the doctor. Some products (such as long-acting tablets/capsules) are not recommended for use in children younger than 12 years. Ask your doctor or pharmacist for more details about using your product safely.

These products do not cure or shorten the length of the common cold and may cause serious side effects. To decrease the risk for serious side effects, carefully follow all dosage directions. Do not use this product to make a child sleepy. Do not give other cough-and-cold medication that might contain the same or similar ingredients (see also Drug Interactions section). Ask the doctor or pharmacist about other ways to relieve cough and cold symptoms (such as drinking enough fluids, using a humidifier or saline nose drops/spray).

How to use NyQuil

See also Warning section.

If you are taking the over-the-counter product, read and follow all directions on the package label. If your doctor has prescribed this medication for you, take as directed by your doctor. If you have any questions, consult your doctor or pharmacist.

Take this medication by mouth with or without food or as directed by your doctor. If stomach upset occurs, it may help to take this medication with food or milk. Drink plenty of fluids when you use this medication unless otherwise directed by your doctor. The fluid will help loosen the mucus in your lungs .

If you are using the liquid form of this medication, carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose. If your liquid form is a suspension, shake the bottle well before each dose.

If you are taking extended-release capsules, swallow them whole. Do not crush or chew extended-release capsules or tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split extended-release tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.

If you are taking the chewable form of this medication, chew it thoroughly before swallowing.

The dosage is based on your age, medical condition, and response to treatment. Do not increase your dose, take it more frequently, or use it for a longer time than directed. Improper use of this medication (abuse) may result in serious harm (including brain damage. seizure. death).

Tell your doctor if your condition persists for more than 1 week, if it worsens, or if it occurs with rash. persistent headache. or fever lasting more than 3 days. These may be symptoms of a serious medical problem and should be checked by a doctor.

Side Effects

See also Warning section.

Drowsiness, dizziness. blurred vision. upset stomach, nausea, nervousness, constipation. or dry mouth /nose/throat may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

If your doctor has prescribed this medication, remember that he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if any of these unlikely but serious side effects occur: mental/mood changes (such as confusion, hallucinations), shaking, trouble urinating.

Tell your doctor right away if any of these rare but serious side effects occur: fast/slow/irregular heartbeat, seizure.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

See also Warning section.

Before taking this product, tell your doctor or pharmacist if you are allergic to any of its ingredients; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

If you have any of the following health problems, consult your doctor or pharmacist before using this medication: breathing problems (such as asthma, emphysema), diabetes, glaucoma, heart problems, high blood pressure, kidney problems, liver disease, seizures, stomach/intestinal problems (such as blockage, constipation, ulcers), overactive thyroid (hyperthyroidism), urination problems (such as trouble urinating due to enlarged prostate, urinary retention).

This drug may make you dizzy or drowsy or cause blurred vision. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely. Avoid alcoholic beverages.

Some brands of this product may contain sugar, alcohol, or aspartame. Caution is advised if you have diabetes, alcohol dependence, liver disease, phenylketonuria (PKU), or any other condition that requires you to limit/avoid these substances in your diet. Ask your doctor or pharmacist about using this product safely.

Before having surgery, tell your doctor or dentist that you are taking this medication.

Older adults may be more sensitive to the effects of this drug, especially dizziness, drowsiness, mental/mood changes, constipation, trouble urinating, fast heartbeat, and blood pressure changes. Dizziness, drowsiness and confusion can increase the risk of falling.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

This medication may pass into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.

Interactions

See also Warning section.

If you are taking this product under your doctor's direction, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.

Taking certain MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Avoid taking isocarboxazid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, or tranylcypromine during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before treatment with this medication. Ask your doctor when to start or stop taking this medication.

Before using this product, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: antihistamines applied to the skin (such as diphenhydramine cream, ointment, spray), ketoconazole.

The ingredients in this product are available in many prescription and nonprescription products. Check the labels on all your medicines (such as pain/fever drugs, diet aids, or cold/allergy products) because they may contain the same or similar ingredients. Using these drugs along with this product could increase side effects (such as fast heartbeat, increased blood pressure, or drowsiness). Tell your doctor or pharmacist if you are taking other products that cause drowsiness including alcohol, antihistamines (such as cetirizine, diphenhydramine), drugs for sleep or anxiety (such as alprazolam, diazepam, zolpidem), muscle relaxants, and narcotic pain relievers (such as codeine). Ask your pharmacist about using those products safely.

This medication may interfere with certain laboratory tests (including urine 5-HIAA), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

Overdose

If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: nausea, vomiting, loss of appetite, sweating, stomach/abdominal pain, extreme tiredness, agitation, confusion, flushing, hallucinations, yellowing eyes/skin, dark urine, seizures. In children, excitement may occur first, and may be followed by: loss of coordination, drowsiness, loss of consciousness, seizures.

Notes

Keep all regular medical and laboratory appointments.

Do not take this product for several days before allergy testing because test results can be affected.

Missed Dose

If you are taking this product on a regular schedule and miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store in a tightly closed container at room temperature between 59-86 degrees F (15-30 degrees C) away from light and moisture. Do not store in the bathroom. Do not freeze liquid forms of this medication. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Information last revised October 2015. Copyright(c) 2015 First Databank, Inc.

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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3920b Series Analog And Digital Radio Test Platform, Aeroflux

3920B Series Analog and Digital Radio Test Platform

Overview

Features

Literature

Technical Data

Software

Manuals & Training

Videos

Newest in low phase noise RF signal generator technology

The 3920B features a new low phase noise RF signal generator in addition to the already advanced functionality available on the Cobham 3900 Series. The 3920B includes many standard features as well as a host of optional test capabilities, digital personalities, and the Auto-Test II Alignment capability.

This firmware is compatible with all the 3900 Series products. See release notes for more information.

The new version of firmware has several new enhancements and bug fixes.

Click on Software Tab above for script downloads.

Testing Capabilities

Analog AM and FM

P25 and P25 Phase II

DMR (MOTOTRBO)

NXDN™

dPMR

TETRA

TEDS (TETRA Enhanced Data Service)

Automatic Test and Alignment of a wide range of mission critical radios

Performance

RF signal generator with SSB phase noise of -110 dBc/Hz at 10 kHz offset

Sensitive receiver for making accurate measurements

2.7 GHz RF frequency range for generate and receive

Full spectrum analyzer and tracking generator with displayed average noise level of -140 dBm

Doxytex Liquid Indications, Side Effects, Warnings, Doxytrex

Doxytex liquid

Doxytex liquid is used for:

Treating symptoms of allergies, such as runny nose, sneezing, nose or throat itching, or itchy, watery eyes. It may also be used for other conditions as determined by your doctor.

Doxytex liquid is an antihistamine. It works by blocking the action of histamine, which reduces the symptoms of an allergic reaction. It also depresses the central nervous system (brain) to produce drowsiness.

Do NOT use Doxytex liquid if:

you are allergic to any ingredient in Doxytex liquid or to any other similar medicine

you are taking sodium oxybate (GHB) or you have taken furazolidone or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) in the past 2 weeks

you are breast-feeding

Contact your doctor or health care provider right away if any of these apply to you.

Before using Doxytex liquid:

Some medical conditions may interact with Doxytex liquid. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have asthma, chronic obstructive pulmonary disease (COPD), chronic bronchitis, emphysema, lung disease, shortness of breath, or sleep apnea

if you have blockage of the stomach, intestine, or urinary tract; difficulty urinating; or a history of diabetes, ulcers, enlargement of the prostate, glaucoma, heart disease, high blood pressure, the blood disease porphyria, seizures, stroke, or thyroid disease

Some MEDICINES MAY INTERACT with Doxytex liquid. Tell your health care provider if you are taking any other medicines, especially any of the following:

Sodium oxybate (GHB) because an increase in sleep duration and a decrease in the ability to breathe are likely to occur

Furazolidone or MAOIs (eg, phenelzine) because serious side effects, such as high blood pressure and seizures, may occur

This may not be a complete list of all interactions that may occur. Ask your health care provider if Doxytex liquid may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Doxytex liquid:

Use Doxytex liquid as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take Doxytex liquid by mouth with or without food.

Use Doxytex liquid exactly as directed on the package, unless instructed differently by your doctor.

Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.

If you miss a dose of Doxytex liquid and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Doxytex liquid.

Important safety information:

Doxytex liquid may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Doxytex liquid with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

Avoid drinking alcohol while you are taking Doxytex liquid. Talk with your doctor before using other medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Doxytex liquid; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.

Doxytex liquid may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.

Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.

Do not become overheated in hot weather or while you are being active; heatstroke may occur.

Doxytex liquid has doxylamine in it. Before you start any new medicine, including one used on the skin, check the label to see if it has doxylamine in it too. If it does or if you are not sure, check with your doctor or pharmacist.

Doxytex liquid may interfere with skin allergy tests. If you are scheduled for a skin test, talk to your doctor. You may need to stop taking Doxytex liquid for a few days before the tests.

Use Doxytex liquid with caution in the ELDERLY; they may be more sensitive to its effects, especially dizziness, sedation, and lightheadedness upon standing.

Do not use Doxytex liquid in CHILDREN younger than 2 years old without talking with the child's doctor; safety and effectiveness in these children have not been confirmed.

Caution is advised when using Doxytex liquid in CHILDREN; they may be more sensitive to its effects, especially excitability.

PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Doxytex liquid while you are pregnant. Doxytex liquid is found in breast milk. Do not breast-feed while taking Doxytex liquid.

Possible side effects of Doxytex liquid:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; drowsiness; dry mouth, throat, and nose.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); convulsions; decreased alertness; decreased urination; excitability; fast heartbeat; hallucinations; seizures; severe drowsiness; tightness or pounding in the chest; tremor; wheezing.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA .

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center. or emergency room immediately. Symptoms may include coma; excitement; hallucinations; loss of consciousness; muscle twitching; seizures; tremor; weakness.

Proper storage of Doxytex liquid:

Store Doxytex liquid at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), or according to the directions on the package label. Store in the original package or container away from heat, moisture, and light. Do not store in the bathroom. Keep Doxytex liquid out of the reach of children and away from pets.

General information:

If you have any questions about Doxytex liquid, please talk with your doctor, pharmacist, or other health care provider.

Doxytex liquid is to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Doxytex liquid or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Doxytex liquid. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Doxytex liquid. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Doxytex liquid.

Review Date: August 8, 2016

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

More about Doxytex (doxylamine)

Candaspor (Clotrimazole) Be-Tabs Pharmaceuticals, Candaspor

Human:

Antifungals

Anti-inflammatory agents

Azoles

Mouth / throat preparations

Non-steroidal antiinflammatory and antirheumatic products

Nonsteroidal anti-inflammatory drugs (NSAIDs)

Preparations for vaginal conditions

Topical anti-infectives with corticosteroids

Topical antifungals and antiparasites

Treatment of inflammation and rheumatism

Indications and usages, anatomical therapeutic chemical and diseases classification codes:

Pharmaceutical companies: manufacturers, researchers, developers, local distributors and suppliers:

Imperacin, Imperacin

Sumycin is used for treating infections caused by certain bacteria. Sumycin is a tetracycline antibiotic. It works by slowing the growth of sensitive bacteria by interfering with the production of proteins needed by the bacteria to grow. Slowing the bacteria's growth allows the body's defense mechanisms to destroy them.

Use Sumycin as directed by your doctor.

Take Sumycin by mouth on an empty stomach at least 1 hour before or 2 hours after eating.

Take Sumycin with a full glass of water (8 oz/240 mL). Do not lie down for 30 minutes after taking Sumycin.

If you also take antacids containing aluminum, calcium, or magnesium; preparations containing bismuth, iron, zinc, or sodium bicarbonate; or calcium rich foods (eg, milk, dairy products, calcium-enriched juices), do not take them within 2 to 3 hours before or after taking Sumycin. Check with your doctor if you have questions.

To clear up your infection completely, take Sumycin for the full course of treatment. Keep taking it even if you feel better in a few days.

If you miss a dose of Sumycin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Sumycin.

Store Sumycin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C), in a tightly closed, light-resistant container. Keep away from heat, moisture, and light. Do not store in the bathroom. Keep Sumycin out of the reach of children and away from pets.

Active Ingredient: Tetracycline hydrochloride.

Do NOT use Sumycin if:

you are allergic to any ingredient in Sumycin or other tetracycline antibiotics (eg, doxycycline)

you are taking acitretin or methoxyflurane.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Sumycin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have diarrhea, a stomach infection, or kidney problems.

Some medicines may interact with Sumycin. Tell your health care provider if you are taking any other medicines, especially any of the following:

Acitretin or isotretinoin because side effects, such as increased pressure in the fluid surrounding the brain, may occur

Digoxin, methotrexate, methoxyflurane, or oral anticoagulants (eg, warfarin) because the risk of their side effects may be increased by Sumycin

Atovaquone, lithium, oral contraceptives (birth control pills), or penicillins (eg, amoxicillin) because their effectiveness may be decreased by Sumycin.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Sumycin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Sumycin may cause dizziness or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Sumycin with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.

Be sure to use Sumycin for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.

Sumycin may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Sumycin. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.

Do not use after expiration date. Outdated medicine is highly toxic to the kidneys.

Long-term or repeated use of Sumycin may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.

Hormonal birth control (eg, birth control pills) may not work as well while you are using Sumycin. To prevent pregnancy, use an extra form of birth control (eg, condoms).

Lab tests may be performed while you use Sumycin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use of Sumycin in children may cause permanent discoloring of the teeth.

Sumycin should be used with extreme caution in children younger 8 years; safety and effectiveness in these children have not been confirmed.

Pregnancy and beast-feeding: Sumycin has been shown to cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Sumycin while you are pregnant. Sumycin is found in breast milk. Do not breast-feed while taking Sumycin.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Black hairy tongue; blurred vision; bulky loose stools; diarrhea; difficulty swallowing; fever; headache; hives; hoarseness; indigestion; inflammation or redness of tongue; joint pain; loss of appetite; mouth sores; nausea; rash; sensitivity to sunlight; sore throat; stomach pain; swelling and itching of the rectum.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); infection (fever, chills, sore throat); itching; nausea; severe skin reaction to the sun; vaginal irritation or discharge; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Athenol, Athenol

Athenol

Important Notice: The Drugs. com international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

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Amlip Tablet Cipla Use, Composition, Dosage, Side Effect, Price And Review - Tablet Tree, Amlip

Amlip

Amlip Tablet - Uses, Composition, Dosage, Side Effects & Reviews

The normal blood pressure is necessary for our healthy life. When our blood pressure increases above the normal values, this condition is called high blood pressure. The higher the blood pressure, the more the heart needs to work harder to supply blood throughout the body. Amlip reduces the high blood pressure as well as protects and cures the severe chest pain. It contains an active ingredient that is Amlodipine which plays an essential role.

This drug reduces the blood pressure and relaxes the blood vessels by blocking the calcium entrance in the blood vessels. As a result, it improves the blood flow as well as the blood pressure and lowers the stress on the heart.

Amlip treats and controls the high blood pressure. It is available online at discounted price at the Tablet Tree.

Amlip Tablet Uses

Amlodipine is an anti-hypertensive drug and belongs to a drug class called calcium channel blocker that opens and relaxes the blood vessels. Thus, it improves the blood flow and lowers the blood pressure.

Amlip Tablet Composition

Each Amlip-5 tablet contains:

Amlip Tablet Dosage

The starting recommended dose of this drug is 5 mg once daily and the maximum dose is 10mg/day. Please consult your doctor and follow his or her recommendations. Please do not self medicate.

Amlip Tablet Side Effects

A side effect is an undesired harmful effect resulting from a drug or other intervention. Side effects can be mild or severe, temporary or permanent. The side effects of this drug are as follows:

Skin Related . Pruritus (severe itching of the skin), Rash

Gastrointestinal . Nausea, Abdominal pain, Dyspepsia (indigestion)

Other . Headache, Fatigue, Dyspnea (difficult or laboured breathing), Muscle spasm

Other Information on Amlip Tablet:

Pharmaceutical Form

Precautions

Do not start or stop this drug without doctor’s or pharmacist's approval

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall during getting treated with this drug

Drinking alcohol can further lower your blood pressure and may increase certain side effects of this drug

Take this drug under the guidance of doctor if you are breast-feeding

Consume this drug as per your doctor’s prescription because it may increase frequency and/or severity of angina during the treatment initiation or dosage increments

Take this drug under your doctor’s guidance if you have had heart failure or hepatic impairment

Tell your doctor of all prescription and nonprescription drug you may consuming

Drug–Drug Interaction

Drug-drug interaction is a situation in which another drug affects the activity of a drug when both are administered together. This drug interact with the following drugs and drug classes:

Calcium

Sildenafil

Tadalafil or Vardenafil

Grapefruit Juice

Contraindications

The contraindications of Amlip are as follows:

Contraindicated in women who are breastfeeding or having an infant

Patients Hypersensitive to its ingredients

Package Content

Each 1 Strip of Amlip-5 contains 10 Tablets

Manufacturer

Ask questions on Amlip to help and support people like you.

Please login to ask a question to our registered phramacists, product experts and the TabletTree. com community. Click here to login.

User Reviews for Amlip. Your feedback matters.

Please login to write a review for Amlip. Let your friends, family and the community know about problems, pre-cautions or side effects that you have faced using this product. Click here to login.

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Disclaimer: In compliance with the Indian Government's Drug and Cosmetic Act and Rules, we do not process requests for Schedule X and other habit forming drugs. For Schedule H and H1 drugs, you will need to upload a valid prescription from a registered medical practitioner before we can process your order.

The information contained on this page is only an educational aid. This information does not intend to be medical advice for individual conditions or treatment. Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. This information is not a substitute for a medical exam, doctor visit or any services provided by medical or healing professionals. Only your doctor can provide you safe and effective advice based on your own physical conditions or symptoms. The use of the www. tablettree. com is at your risk. These products or information are provided as-is and without any warranties of any kind, either expressed or implied. www. tablettree. com makes no representation or warranty to the accuracy or completeness of any of the information. www. tablettree. com makes no warranties to the opinions or services or data that you may access as a result of using our website. All implied warranties are hereby excluded. www. tablettree. com does not assume any responsibility or risk for your use of www. tablettree. com.

Graham Masterton, Masaton

Graham Masterton

( 1946 - )

aka Dr Jan Berghoff, Alan Blackwood, Thomas Luke, Anton Rimart, Angel Smith, Edward Thorne. Katherine Winston

Graham Masterton has published more than thirty-five horror novels and three short story collections: his debut novel, The Manitou, was an instant bestseller. His more recent critically acclaimed novels include The Chosen Child, Trauma, Spirit, and Prey. He is an Edgar Award and Bram Stoker Award-winner and a World Fantasy Award-nominee. In addition to his prolific fiction career, Masterton is also renowned for his bestselling sex guides, including How to Drive Your Woman Wild in Bed and Wild Sex for New Lovers. Born in Edinburgh in 1946, he lives with his wife Wiescka in a Gothic mansion in Cork, Ireland, where he is currently working on his next horror novel. 

Anthologies containing stories by Graham Masterton

Hurry Monster [short story] (1990 )

British Fantasy Society Best Novel nominee (1996 ). The House That Jack Built

Bram Stoker Best Short Story nominee (1997 ). The Secret Shih Tan

World Fantasy Best Short Story nominee (1997 ). Underbed

British Fantasy Society Best Collection nominee (1998 ). Manitou Man: The World of Graham Masterton

World Fantasy Best Collection nominee (1999 ). Manitou Man: The World of Graham Masterton

Graham Masterton recommends

Slob (1987 ) ( Chaingang . book 1) Rex Miller "Terrific! Rex Miller writes like a truck-driver tailgating you at 80 mph in a Kenworth TransOrient. In Slob he induces genuine panic - making you read faster than you want to - too scared to go on, too terrified to stop."

Visitors to this page also looked at these authors

Buy Chlocodemin Betamethasone Online Without Prescriptions, Chlocodemin

Betnovate is used to help relieve redness, itching, swelling, or other discomfort caused by skin conditions. This medicine is a corticosteroid (cortisone-like medicine or steroid).

Use Betnovate as directed by your doctor.

Betnovate is for use on the skin only. Do not get it in your eyes.

Wash your hands with soap and water before and after using this medicine.

Apply a thin layer of this medicine to the affected area of the skin. Rub it in gently.

Do not use cosmetics or other skin care products on the treated areas.

Do not bandage or otherwise wrap the skin being treated unless directed to do so by your doctor.

If the medicine is applied to the diaper area of an infant, do not use tight-fitting diapers or plastic pants unless directed to do so by your doctor.

If your doctor ordered an occlusive dressing or airtight covering to be applied over the medicine, make sure you know how to apply it. Occlusive dressings increase the amount of medicine absorbed through your skin, so use them only as directed. If you have any questions about this, check with your doctor.

Using too much of this medicine or using it for a long time may increase your risk of having adrenal gland problems.

If you miss a dose of Betnovate, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For redness, itching, and swelling of the skin:

Adults: Apply to the affected area of the skin one to three times per day.

Children: Use and dose must be determined by your doctor.

Ask your health care provider any questions you may have about how to use Betnovate.

Store Betnovate at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Keep Betnovate out of the reach of children and away from pets.

Active Ingredient: Betamethasone.

Do NOT use Betnovate if:

you are allergic to any ingredient in Betnovate

you are taking mifepristone

you have a systemic fungal infection

you are scheduled to have a smallpox vaccine

you have a certain bleeding disorder (idiopathic thrombocytopenic purpura).

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Betnovate. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of bleeding problems, heart problems (eg, congestive heart failure [CHF]), heart attack, high blood pressure, kidney problems, liver problems, diabetes, seizures, an underactive thyroid, adrenal gland problems, any mental or mood problems, or low blood potassium levels

if you have or have recently had a bacterial, fungal, malarial, viral, or other type of infection; herpes infection of the eye; chickenpox; measles; shingles; or a head or brain injury

if you have HIV infection or tuberculosis (TB), or if you have ever had a positive TB skin test

if you have any stomach problems (eg, ulcers), intestinal problems (eg, blockage, perforation, infection, unexplained diarrhea, diverticulitis, ulcerative colitis), recent intestinal surgery, or inflammation of the esophagus

if you have weak bones (eg, osteoporosis) or muscle problems (eg, myasthenia gravis)

if you have had any recent vaccinations (eg, smallpox)

if you have a history of joint surgery or any joint problems (eg, fracture, infection).

Some medicines may interact with Betnovate. Tell your health care provider if you are taking any other medicines, especially any of the following:

Aprepitant, clarithromycin, cyclosporine, diltiazem, erythromycin, itraconazole, ketoconazole, or troleandomycin because side effects, such as adrenal gland or nervous system problems (eg, seizures), may occur

Barbiturates (eg, phenobarbital), carbamazepine, hydantoins (eg, phenytoin), lithium, or rifampin because they may decrease Betnovate's effectiveness

Aspirin, live vaccines, mifepristone, or ritodrine because the risk of their side effects may be increased by Betnovate.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Betnovate may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Betnovate may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.

If you have not had chickenpox, shingles, or measles, avoid contact with anyone who does.

Tell your doctor or dentist that you take Betnovate before you receive any medical or dental care, emergency care, or surgery.

Diabetes patients - Betnovate may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

If you use Betnovate for an extended period of time, your body may not produce enough natural steroids for up to several months after you stop using it. Severe symptoms may occur if you experience injury, surgery, infection, or loss of blood electrolytes. Contact your doctor immediately if you experience any of these events. You may need to begin taking additional corticosteroids.

If you have had Betnovate injected into a joint and you experience increased pain along with swelling, decreased joint movement, fever, and general feeling of being unwell, contact your doctor.

Talk with your doctor before you receive any vaccine while you are using Betnovate.

Lab tests, including adrenal function tests and blood pressure monitoring, may be performed while you use Betnovate. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Betnovate may have benzyl alcohol in it. Do not use it in newborns or infants. It may cause serious and sometimes fatal nervous system problems and other side effects.

Corticosteroids may affect growth rate in children and teenagers in some cases. They may need regular growth checks while they use Betnovate.

Betnovate should be used with extreme caution in children; safety and effectiveness in children have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Betnovate while you are pregnant. Betnovate is found in breast milk. If you are or will be breast-feeding while you use Betnovate, check with your doctor. Discuss any possible risks to your baby.

If you suddenly stop taking Betnovate, you may have withdrawal symptoms, These may include unbalanced hormones (in both men and women).

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Acne; clumsiness; dizziness; facial flushing; general body discomfort; headache; increased appetite; increased sweating; lightheadedness; nausea; nervousness; sleeplessness; upset stomach.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; changes in body fat; changes in menstrual periods; changes in skin color; chest pain; easy bruising or bleeding; irregular heartbeat; mental or mood changes (eg, depression); muscle pain, wasting, or weakness; seizures; severe nausea or vomiting; sudden severe dizziness or headache; swelling of feet or legs; symptoms of infection (eg, chills, fever, sore throat); tendon or bone pain; thinning of the skin; unusual skin sensation; unusual weight gain; vision changes or other eye problems; vomit that looks like coffee grounds.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

European Medicines Agency - Veterinary Medicines, Rheumocam

Rheumocam

About

This is a summary of the European Public Assessment Report. Its purpose is to explain how the assessment done by the Committee for Medicinal Products for Veterinary Use (CVMP) on the basis of the documentation provided, led to the recommendations on the conditions of use.

This summary cannot replace a face-to-face discussion with your veterinarian. If you need more information about your animal’s medical condition or treatment, contact your veterinarian. If you want more information on the basis of the CVMP recommendations, read the Scientific Discussion (also part of the EPAR).

Rheumocam is a veterinary medicine that contains the active substance meloxicam. It is available as granules in sachet (330 mg), oral suspension (1.5 mg/ml and 15 mg/ml), chewable tablets (1 mg and 2.5 mg) and solution for injection (5 mg/ml and 20 mg/ml).

Rheumocam is a ‘generic’, which means that Rheumocam is similar to a ‘reference veterinary medicine’ already authorised in the EU (Metacam).

In cattle, Rheumocam is used together with appropriate antibiotic therapy, to reduce clinical signs of disease, in acute respiratory infection (infection of the lungs and airways). It can be used in diarrhoea in combination with oral re-hydration therapy (medicines given by mouth to restore water levels in the body) to reduce clinical signs of the disease in calves of over one week of age and young, non-lactating cattle. It can be used as supportive therapy in the treatment of acute mastitis (inflammation of the udder), in combination with antibiotics.

In pigs, Rheumocam is used in non-infectious locomotor disorders (diseases that affect the ability to move) to reduce the symptoms of lameness and inflammation, for the relief of post-operative pain associated with minor soft tissue surgery such as castration, and for supportive therapy together with appropriate antibiotic therapy in the treatment of diseases that occur after farrowing (giving birth) such as puerperal septicaemia and toxaemia (mastitis-metritis-agalactia syndrome). Septicaemia and toxaemia are conditions where bacteria circulate in the blood and produce harmful substances (toxins).

In horses, Rheumocam is used for the relief of pain associated with colic (abdominal pain) and for the alleviation of inflammation and relief of pain in both acute and chronic musculo-skeletal disorders (disorders affecting the muscles and bones).

In dogs, Rheumocam is used to reduce post-operative pain and inflammation following orthopaedic (e. g. fracture operation) and soft tissue surgery. Moreover, it is used for the alleviation of inflammation and pain in both acute and chronic musculo-skeletal disorders in dogs.

In cats, Rheumocam is used to reduce post-operative pain and inflammation after ovariohysterectomy (spay operation), orthopaedic and minor soft tissue surgery.

The formulation to use depends on the animal and the condition being treated.

Rheumocam contains meloxicam, which belongs to a class of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). Meloxicam acts by blocking an enzyme called cyclo-oxygenase which is involved in the production of prostaglandins. As prostaglandins are substances that trigger inflammation, pain, exudation (fluid that leaks out of blood vessels during an inflammation) and fever, meloxicam reduces these signs of disease.

Since Rheumocam is a generic medicine, studies have been conducted to determine that it is bioequivalent to the reference medicine, Metacam. Two medicines are bioequivalent when they produce the same levels of the active substance in the body.

Based on the findings of the studies, Rheumocam was considered to be bioequivalent to the reference medicine.

Consequently, Rheumocam’s benefit is taken as being the same as that of the reference medicine.

Side effects sometimes seen with other NSAIDs, such as loss of appetite, vomiting, diarrhoea, blood appearing in the stools, renal (kidney) failure and apathy (lack of vitality) are occasionally seen with Rheumocam in dogs and cats. These generally occur within the first week of treatment and usually disappear once treatment has stopped. In very rare cases they may be serious or fatal.

In horses given the granules in sachet and oral suspension, slight urticaria (itchy rash) and diarrhoea were observed in clinical trials.

A slight temporary swelling at the injection site following injection under the skin was observed in cattle and pigs. In horses, a temporary swelling at the injection site can occur but resolves without intervention.

In cattle, pigs and horses in very rare cases anaphylactoid reactions (allergic) which may be serious (including fatal) may occur and should be treated symptomatically.

Rheumocam must not be used in animals with liver, heart or kidney problems, bleeding disorders, or suffering from irritation or ulcers of the digestive tract. It must not be used in animals which are hypersensitive (allergic) to the active substance or to any of the other ingredients.

Rheumocam should not be used in pregnant or lactating horses and dogs, but it can be used during pregnancy and lactation for cattle and pigs.

Rheumocam must not be used in dogs or horses less than six weeks of age or in cattle less than one week of age when used in the treatment of diarrhoea. It must not be used in cats weighing less than 2 kg.

People who are hypersensitive (allergic) to NSAIDs should avoid contact with Rheumocam. If someone swallows or accidentally injects themselves with the medicine, the advice of a doctor should be sought immediately.

The withdrawal period is the time allowed after administration of the medicine before the animal can be slaughtered and the meat used for human consumption. It is also the time allowed after administration of the medicine before the milk can be used for human consumption.

For meat the withdrawal period is 15 days and for milk it is five days.

For meat the withdrawal period is five days.

For meat the withdrawal period is five days for the 20 mg/ml solution for injection and three days for the granules in sachet and 15 mg/ml oral suspension. The product is not authorised for use in horses producing milk for human consumption.

The CVMP considered that, in accordance with European Union requirements, Rheumocam has been shown to be bioequivalent to Metacam. Therefore the CVMP’s view was that, as for Metacam, Rheumocam’s benefits are greater than its risks when used for the approved indications and the Committee recommended that Rheumocam be given a marketing authorisation.

The European Commission granted a marketing authorisation valid throughout the European Union, for Rheumocam on 10 January 2008. Information on the prescription status of this product may be found on the label of the carton.

Pharmacotherapeutic group

Anti-inflammatory and anti-rheumatic products, non-steroids, oxicams

Therapeutic indication

Alleviation of inflammation and pain in both acute and chronic musculo-skeletal disorders in dogs. To reduce post-operative pain and inflammation following orthopaedic and soft tissue surgery.

Reduction of post-operative pain after ovariohysterectomy and minor soft tissue surgery.

For use in acute respiratory infection with appropriate antibiotic therapy to reduce clinical signs. For use in diarrhoea in combination with oral re-hydration therapy to reduce clinical signs in calves of over one week of age and young, non-lactating cattle. For adjunctive therapy in the treatment of acute mastitis, in combination with antibiotic therapy.

For use in non-infectious locomotor disorders to reduce the symptoms of lameness and inflammation. For adjunctive therapy in the treatment of puerperal septicaemia and toxaemia (mastitis-metritis-agalactia syndrome) with appropriate antibiotic therapy. For the relief of post operative pain associated with minor soft tissue such as castration.

Alleviation of inflammation and relief of pain in both acute and chronic musculo-skeletal disorders in horses..

For the relief of pain associated with equine colic.

Assessment History

Changes since initial authorisation of medicine

Topiramate Indications, Side Effects, Warnings, Topinmate

Topiramate

Treating seizures in certain patients. It may be used alone or with other medicines. It is also used to prevent migraine headaches. It may also be used for other conditions as determined by your doctor.

Topiramate is an anticonvulsant that is also effective for preventing migraine headaches. It works by affecting several chemicals in the brain that help to reduce seizure activity and prevent migraine headaches from occurring.

Do NOT use topiramate if:

you are allergic to any ingredient in topiramate

you have high blood acid levels (metabolic acidosis) and are also taking a medicine that contains metformin. Check with your doctor or pharmacist if you are not sure if a medicine you take contains metformin

Contact your doctor or health care provider right away if any of these apply to you.

Before using topiramate:

Some medical conditions may interact with topiramate. Tell your health care provider if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are able to become pregnant

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have eye problems (eg, glaucoma), liver or kidney problems, kidney stones, metabolism problems, osteoporosis (weak bones), soft bones, bleeding problems, or low blood platelet levels

if you have diarrhea, lung or breathing problems, low bicarbonate levels in the blood, or a growth problem, or you will be having surgery

if you drink alcohol regularly, you are on a diet high in fat and low in carbohydrates (ketogenic diet), or you are receiving kidney dialysis

if you have a history of status epilepticus (continuous seizure activity or a series of seizures without a full return to consciousness) or metabolic acidosis

if you have a history of mental or mood problems (eg, depression), or suicidal thoughts or actions

if you take any other medicine for seizures

Some MEDICINES MAY INTERACT with topiramate. Tell your health care provider if you are taking any other medicines, especially any of the following:

Anticoagulants (eg, warfarin), aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) because the risk of bleeding may be increased

Anticholinergics (eg, benztropine) or carbonic anhydrase inhibitors (eg, acetazolamide, dichlorphenamide, zonisamide) because the risk of decreased sweating may be increased

Valproic acid because the risk of high blood ammonia levels or low body temperature may be increased

Pioglitazone because blood glucose control may be altered; monitor your blood sugar carefully if you use topiramate with pioglitazone

Hydrochlorothiazide or metformin because they may increase the risk of topiramate's side effects

Carbamazepine or hydantoins (eg, phenytoin) because they may decrease topiramate's effectiveness

Amitriptyline or lithium because the risk of their side effects may be increased by topiramate

Cabazitaxel, hormonal birth control (eg, birth control pills), or ulipristal because their effectiveness may be decreased by topiramate

This may not be a complete list of all interactions that may occur. Ask your health care provider if topiramate may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use topiramate:

Use topiramate as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Topiramate comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get topiramate refilled.

Take topiramate by mouth with or without food.

Drinking extra fluids while you are taking topiramate is recommended. Doing so may help to prevent kidney stones from forming. Check with your doctor for instructions.

Swallow whole. Do not crush or chew. The tablet may leave a bitter taste.

Do not suddenly stop taking topiramate. Suddenly stopping topiramate may increase the risk of seizures. If you need to stop topiramate, your doctor will gradually lower your dose.

If you miss a dose of topiramate, take it as soon as possible. If it is within 6 hours of your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Contact your doctor if you miss more than 1 dose of topiramate.

Ask your health care provider any questions you may have about how to use topiramate.

Important safety information:

Topiramate may cause drowsiness, dizziness, confusion, trouble concentrating, or vision changes. These effects may be worse if you take it with alcohol or certain medicines. Use topiramate with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

Do not change your dose without checking with your doctor.

Do not drink alcohol while you take topiramate.

Check with your doctor before you use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are taking topiramate; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.

Topiramate may reduce sweating, which could raise body temperature, especially in children. This risk is greater in hot weather and/or during vigorous exercise. Drink plenty of fluids. Dress lightly in hot climates or when exercising. Check carefully for signs of decreased sweating. If this occurs, promptly seek cooler or air-conditioned shelter and/or stop exercising. Seek medical attention right away if you have decreased sweating, fever, mental or mood changes, headache, or dizziness.

Topiramate may cause high blood acid levels (metabolic acidosis). The risk may be greater in children and in patients with kidney problems, severe breathing problems, or diarrhea. It may also be greater in patients who are taking certain other medicines (eg, acetazolamide), will be having surgery, or are on a ketogenic diet. Over a period of time, metabolic acidosis may cause kidney stones, bone problems, or decreased growth in children. Contact your doctor immediately if you experience fast breathing, unusual tiredness or weakness, sluggishness, persistent loss of appetite, or fast or irregular heartbeat.

Topiramate may cause high blood ammonia levels (hyperammonemia). This risk may be greater in patients with metabolism problems or certain liver problems. It may also be greater in patients who are taking valproic acid. Contact your doctor immediately if you experience decreased alertness, mental changes, sluggishness, unusual tiredness, or vomiting.

Patients who take topiramate may be at increased risk of suicidal thoughts or actions. The risk may be greater in patients who have had suicidal thoughts or actions in the past. Watch patients who take topiramate closely. Contact the doctor at once if new, worsened, or sudden symptoms such as depressed mood; anxious, restless, or irritable behavior; panic attacks; or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur.

Topiramate may cause serious eye problems that could lead to permanent loss of vision if not treated. Seek medical attention right away if you experience new eye symptoms (eg, blurred vision or other vision changes, eye pain or redness).

Tell your doctor or dentist that you take topiramate before you receive any medical or dental care, emergency care, or surgery.

Hormonal birth control (eg, birth control pills) may not work as well while you are using topiramate. To prevent pregnancy, use an extra form of birth control (eg, condoms). Discuss any questions or concerns with your doctor.

Lab tests, including serum bicarbonate levels, may be performed while you use topiramate. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Caution is advised when using topiramate in CHILDREN; they may be more sensitive to its effects, especially decreased sweating and decreased bicarbonate levels.

Topiramate may affect growth rate in CHILDREN and teenagers in some cases. They may need regular growth checks while they take topiramate.

Topiramate may cause birth defects if you take it while you are pregnant. If you may become pregnant, discuss other possible treatment options with your doctor. If a decision is made to take topiramate, use effective birth control while you are taking it. Talk with your doctor about the best kind of birth control to use while taking topiramate, if you are planning to become pregnant, and if you have questions or concerns about this information.

PREGNANCY and BREAST-FEEDING: Topiramate may cause birth defects if you take it while you are pregnant. If you think you may be pregnant, contact your doctor right away. You will need to discuss the benefits and risks of taking topiramate while you are pregnant. You and your doctor will need to decide if you will continue to take topiramate while you are pregnant. Topiramate is found in breast milk. If you are or will be breast-feeding while you take topiramate, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of topiramate:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; drowsiness; dry mouth; flushing; headache; loss of appetite; nausea; nervousness; stomach pain or upset; symptoms of upper respiratory tract infection (eg, cough, mild sore throat, running or stuffy nose, sneezing); taste changes; tiredness; trouble sleeping; weakness; weight loss.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bone pain; burning, numbness, or tingling; chest pain; confusion; decreased coordination; decreased or painful urination; fever, chills, or persistent cough or sore throat; loss of consciousness; memory problems; menstrual changes; muscle or joint pain, cramps, or weakness; new or worsening mental, mood, or behavior changes (eg, aggressiveness, agitation, anxiety, depression, exaggerated feeling of well-being, hostility, impulsiveness, inability to sit still, irritability, panic attacks, restlessness); red, swollen, blistered, or peeling skin; ringing in the ears; severe or persistent drowsiness; severe stomach, side, or back pain; significant weight loss; speech problems; stupor; suicidal thoughts or actions; symptoms of bleeding (eg, throwing up blood or vomit that looks like coffee grounds; coughing up blood; blood in urine; black, red, or tarry stools; bleeding from the gums; unusual vaginal bleeding; bruises without a reason or bruises that get bigger; any bleeding that is severe or that you cannot stop); tremor; trouble focusing; trouble walking; unusual eye movements.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA .

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center. or emergency room immediately.

Proper storage of topiramate:

Store topiramate at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, light, and moisture. Do not store in the bathroom. Keep topiramate out of the reach of children and away from pets.

General information:

If you have any questions about topiramate, please talk with your doctor, pharmacist, or other health care provider.

Topiramate is to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take topiramate or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about topiramate. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to topiramate. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using topiramate.

Review Date: August 8, 2016

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

More about topiramate

Calcitriol - Fda Prescribing Information, Side Effects And Uses, Citrol

Calcitriol

Calcitriol Oral Solution is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body. Calcitriol Oral Solution is available as an oral solution, for oral administration, containing 1 mcg/mL of Calcitriol. Calcitriol Oral Solution contains butylated hydroxyanisole (BHA), butylated hydroxytolulene (BHT) and medium chain triglycerides.

Calcitriol is a white to almost white, crystalline compound which occurs naturally in humans. It has a calculated molecular weight of 416.6 and is soluble in organic solvents but relatively insoluble in water. Chemically, Calcitriol is 9,10-seco(5Z,7E)-5,7,10(19)-cholestatriene-1α, 3β, 25-triol and has the following structural formula:

The other names frequently used for Calcitriol are 1α,25-dihydroxycholecalciferol, 1,25-dihydroxyvitamin D 3. 1,25-DHCC, 1,25(OH) 2 D 3 and 1,25-diOHC.

Calcitriol - Clinical Pharmacology

Man’s natural supply of vitamin D depends mainly on exposure to the ultraviolet rays of the sun for conversion of 7-dehydrocholesterol in the skin to vitamin D 3 (cholecalciferol). Vitamin D 3 must be metabolically activated in the liver and the kidney before it is fully active as a regulator of calcium and phosphorus metabolism at target tissues. The initial transformation of vitamin D 3 is catalyzed by a vitamin D 3 -25-hydroxylase enzyme (25-OHase) present in the liver, and the product of this reaction is 25-hydroxyvitamin D 3 [25-(OH)D 3 ]. Hydroxylation of 25-(OH)D 3 occurs in the mitochondria of kidney tissue, activated by the renal 25-hydroxyvitamin D 3 -1 alpha-hydroxylase (alpha-OHase), to produce 1,25-(OH) 2 D 3 (Calcitriol), the active form of vitamin D 3. Endogenous synthesis and catabolism of Calcitriol, as well as physiological control mechanisms affecting these processes, play a critical role regulating the serum level of Calcitriol. Physiological daily production is normally 0.5 to 1 mcg and is somewhat higher during periods of increased bone synthesis (e. g. growth or pregnancy).

Pharmacodynamics

The two known sites of action of Calcitriol are intestine and bone. A Calcitriol receptor-binding protein appears to exist in the mucosa of human intestine. Additional evidence suggests that Calcitriol may also act on the kidney and the parathyroid glands. Calcitriol is the most active known form of vitamin D 3 in stimulating intestinal calcium transport. In acutely uremic rats Calcitriol has been shown to stimulate intestinal calcium absorption.

The kidneys of uremic patients cannot adequately synthesize Calcitriol, the active hormone formed from precursor vitamin D. Resultant hypocalcemia and secondary hyperparathyroidism are a major cause of the metabolic bone disease of renal failure. However, other bone-toxic substances which accumulate in uremia (e. g. aluminum) may also contribute.

The beneficial effect of Calcitriol in renal osteodystrophy appears to result from correction of hypocalcemia and secondary hyperparathyroidism. It is uncertain whether Calcitriol produces other independent beneficial effects. Calcitriol treatment is not associated with an accelerated rate of renal function deterioration. No radiographic evidence of extraskeletal calcification has been found in predialysis patients following treatment. The duration of pharmacologic activity of a single dose of Calcitriol is about 3 to 5 days.

Pharmacokinetics

Absorption

Calcitriol is rapidly absorbed from the intestine. Peak serum concentrations (above basal values) were reached within 3 to 6 hours following oral administration of single doses of 0.25 to 1 mcg of Calcitriol. Following a single oral dose of 0.5 mcg, mean serum concentrations of Calcitriol rose from a baseline value of 40 ± 4.4 (SD) pg/mL to 60 ± 4.4 pg/mL at 2 hours, and declined to 53 ± 6.9 at 4 hours, 50 ± 7 at 8 hours, 44 ± 4.6 at 12 hours and 41.5 ± 5.1 at 24 hours.

Following multiple-dose administration, serum Calcitriol levels reached steady-state within 7 days.

Calcitriol is approximately 99.9% bound in blood. Calcitriol and other vitamin D metabolites are transported in blood, by an alpha-globulin vitamin D binding protein. There is evidence that maternal Calcitriol may enter the fetal circulation. Calcitriol is transferred into human breast milk at low levels (i. e. 2.2 ± 0.1 pg/mL).

In vivo and in vitro studies indicate the presence of two pathways of metabolism for Calcitriol. The first pathway involves the 24-hydroxylase as the first step in catabolism of Calcitriol. There is definite evidence of 24-hydroxylase activity in the kidney; this enzyme is also present in many target tissues which possess the vitamin D receptor such as the intestine. The end product of this pathway is a side chain shortened metabolite, calcitroic acid. The second pathway involves the conversion of Calcitriol via the stepwise hydroxylation of carbon-26 and carbon-23, and cyclization to yield ultimately 1α, 25R(OH) 2 -26, 23S-lactone D 3. The lactone appears to be the major metabolite circulating in humans, with mean serum concentrations of 131 ± 17 pg/mL. In addition, several other metabolites of Calcitriol have been identified: 1α, 25(OH) 2 -24-oxo-D 3 ; 1α, 23,25(OH) 3 -24-oxo-D 3 ; 1α, 24R,25(OH) 3 D 3 ; 1α, 25S,26(OH) 3 D 3 ; 1α, 25(OH) 2 -23-oxo-D 3 ; 1α, 25R,26(OH) 3 -23-oxo-D 3 ; 1α, (OH)24,25,26,27-tetranor-COOH-D 3 .

Enterohepatic recycling and biliary excretion of Calcitriol occur. The metabolites of Calcitriol are excreted primarily in feces. Following intravenous administration of radiolabeled Calcitriol in normal subjects, approximately 27% and 7% of the radioactivity appeared in the feces and urine, respectively, within 24 hours. When a 1 mcg oral dose of radiolabeled Calcitriol was administered to normal subjects, approximately 10% of the total radioactivity appeared in urine within 24 hours. Cumulative excretion of radioactivity on the sixth day following intravenous administration of radiolabeled Calcitriol averaged 16% in urine and 49% in feces. The elimination half-life of Calcitriol in serum after single oral doses is about 5 to 8 hours in normal subjects.

Special Populations

The steady-state pharmacokinetics of oral Calcitriol were determined in a small group of pediatric patients (age range: 1.8 to 16 years) undergoing peritoneal dialysis. Calcitriol was administered for 2 months at an average dose of 10.2 ng/kg (SD 5.5 ng/kg). In this pediatric population, mean C max was 116 pmol/L, mean serum half-life was 27.4 hours, and mean clearance was 15.3 mL/hr/kg. 1

No studies have examined the pharmacokinetics of Calcitriol in geriatric patients.

Controlled studies examining the influence of gender on Calcitriol have not been conducted.

Controlled studies examining the influence of hepatic disease on Calcitriol have not been conducted.

Lower predose and peak Calcitriol levels in serum were observed in patients with nephrotic syndrome and patients undergoing hemodialysis compared with healthy subjects. The elimination half-life of Calcitriol increased by at least twofold in chronic renal failure and hemodialysis patients compared with healthy subjects. Peak serum levels in patients with nephrotic syndrome were reached in 4 hours. For patients requiring hemodialysis peak serum levels were reached in 8 to 12 hours; half-lives were estimated to be 16.2 and 21.9 hours, respectively.

Indications and Usage for Calcitriol

Predialysis Patients

Calcitriol is indicated in the management of secondary hyperparathyroidism and resultant metabolic bone disease in patients with moderate to severe chronic renal failure (Ccr 15 to 55 mL/min) not yet on dialysis. In children, the creatinine clearance value must be corrected for a surface area of 1.73 square meters. A serum iPTH level of ≥100 pg/mL is strongly suggestive of secondary hyperparathyroidism.

Dialysis Patients

Calcitriol is indicated in the management of hypocalcemia and the resultant metabolic bone disease in patients undergoing chronic renal dialysis. In these patients, Calcitriol administration enhances calcium absorption, reduces serum alkaline phosphatase levels, and may reduce elevated parathyroid hormone levels and the histological manifestations of osteitis fibrosa cystica and defective mineralization.

Hypoparathyroidism Patients

Calcitriol is also indicated in the management of hypocalcemia and its clinical manifestations in patients with postsurgical hypoparathyroidism, idiopathic hypoparathyroidism, and pseudohypoparathyroidism.

Contraindications

Calcitriol should not be given to patients with hypercalcemia or evidence of vitamin D toxicity. Use of Calcitriol in patients with known hypersensitivity to Calcitriol (or drugs of the same class) or any of the inactive ingredients is contraindicated.

Warnings

Overdosage of any form of vitamin D is dangerous (see OVERDOSAGE ). Progressive hypercalcemia due to overdosage of vitamin D and its metabolites may be so severe as to require emergency attention. Chronic hypercalcemia can lead to generalized vascular calcification, nephrocalcinosis and other soft-tissue calcification. The serum calcium times phosphate (Ca x P) product should not be allowed to exceed 70. Radiographic evaluation of suspect anatomical regions may be useful in the early detection of this condition.

Calcitriol is the most potent metabolite of vitamin D available. The administration of Calcitriol Oral Solution to patients in excess of their daily requirements can cause hypercalcemia, hypercalciuria and hyperphosphatemia. Therefore, pharmacologic doses of vitamin D and its derivatives should be withheld during Calcitriol treatment to avoid possible additive effects and hypercalcemia. If treatment is switched from ergocalciferol (vitamin D 2 ) to Calcitriol, it may take several months for the ergocalciferol level in the blood to return to the baseline value (see OVERDOSAGE ).

Calcitriol increases inorganic phosphate levels in serum. While this is desirable in patients with hypophosphatemia, caution is called for in patients with renal failure because of the danger of ectopic calcification. A non-aluminum phosphate-binding compound and a low-phosphate diet should be used to control serum phosphorus levels in patients undergoing dialysis.

Magnesium-containing preparations (e. g. antacids) and Calcitriol should not be used concomitantly in patients on chronic renal dialysis because such use may lead to the development of hypermagnesemia.

Studies in dogs and rats given Calcitriol for up to 26 weeks have shown that small increases of Calcitriol above endogenous levels can lead to abnormalities of calcium metabolism with the potential for calcification of many tissues in the body.

Precautions

General

Excessive dosage of Calcitriol induces hypercalcemia and in some instances hypercalciuria; therefore, early in treatment during dosage adjustment, serum calcium should be determined twice weekly. In dialysis patients, a fall in serum alkaline phosphatase levels usually antedates the appearance of hypercalcemia and may be an indication of impending hypercalcemia. An abrupt increase in calcium intake as a result of changes in diet (e. g. increased consumption of dairy products) or uncontrolled intake of calcium preparations may trigger hypercalcemia.

Should hypercalcemia develop, treatment with Calcitriol should be stopped immediately. During periods of hypercalcemia, serum calcium and phosphate levels must be determined daily. When normal levels have been attained, treatment with Calcitriol can be continued, at a daily dose of 0.25 mcg lower than that previously used. An estimate of daily dietary calcium intake should be made and the intake adjusted when indicated. Calcitriol should be given cautiously to patients on digitalis, because hypercalcemia in such patients may precipitate cardiac arrhythmias.

Immobilized patients, e. g. those who have undergone surgery, are particularly exposed to the risk of hypercalcemia.

In patients with normal renal function, chronic hypercalcemia may be associated with an increase in serum creatinine. While this is usually reversible, it is important in such patients to pay careful attention to those factors which may lead to hypercalcemia. Calcitriol therapy should always be started at the lowest possible dose and should not be increased without careful monitoring of the serum calcium. An estimate of daily dietary calcium intake should be made and the intake adjusted when indicated.

Patients with normal renal function taking Calcitriol should avoid dehydration. Adequate fluid intake should be maintained.

Information for Patients

The patient and his or her caregivers should be informed about compliance with dosage instructions, adherence to instructions about diet and calcium supplementation and avoidance of the use of unapproved nonprescription drugs. Patients and their caregivers should also be carefully informed about the symptoms of hypercalcemia (see ADVERSE REACTIONS ).

The effectiveness of Calcitriol therapy is predicated on the assumption that each patient is receiving an adequate daily intake of calcium. Patients are advised to have a dietary intake of calcium at a minimum of 600 mg daily. The U. S. RDA for calcium in adults is 800 mg to 1200 mg.

Laboratory Tests

For dialysis patients, serum calcium, phosphorus, magnesium, and alkaline phosphatase should be determined periodically. For hypoparathyroid patients, serum calcium, phosphorus, and 24-hour urinary calcium should be determined periodically. For predialysis patients, serum calcium, phosphorus, alkaline phosphatase, creatinine, and intact PTH (iPTH) should be determined initially. Thereafter, serum calcium, phosphorus, alkaline phosphatase, and creatine should be determined monthly for a 6-month period and then determined periodically. Intact PTH (iPTH) should be determined periodically every 3 to 4 months at the time of visits. During the titration period of treatment with Calcitriol, serum calcium levels should be checked at least twice weekly (see DOSAGE AND ADMINISTRATION ).

Drug Interactions

Cholestyramine has been reported to reduce intestinal absorption of fat-soluble vitamins; as such it may impair intestinal absorption of Calcitriol (see WARNINGS and PRECAUTIONS. General ).

The coadministration of phenytoin or phenobarbital will not affect plasma concentrations of Calcitriol, but may reduce endogenous plasma levels of 25(OH)D 3 by accelerating metabolism. Since blood level of Calcitriol will be reduced, higher doses of Calcitriol may be necessary if these drugs are administered simultaneously.

Thiazides are known to induce hypercalcemia by the reduction of calcium excretion in urine. Some reports have shown that the concomitant administration of thiazides with Calcitriol causes hypercalcemia. Therefore, precaution should be taken when coadministration is necessary.

Calcitriol dosage must be determined with care in patients undergoing treatment with digitalis, as hypercalcemia in such patients may precipitate cardiac arrhythmias (see PRECAUTIONS. General ).

Ketoconazole may inhibit both synthetic and catabolic enzymes of Calcitriol. Reductions in serum endogenous Calcitriol concentrations have been observed following the administration of 300 mg/day to 1200 mg/day ketoconazole for a week to healthy men. However, in vivo drug interaction studies of ketoconazole with Calcitriol have not been investigated.

A relationship of functional antagonism exists between vitamin D analogues, which promote calcium absorption, and corticosteroids, which inhibit calcium absorption.

Since Calcitriol also has an effect on phosphate transport in the intestine, kidneys and bones, the dosage of phosphate-binding agents must be adjusted in accordance with the serum phosphate concentration.

Since Calcitriol is the most potent active metabolite of vitamin D 3. pharmacological doses of vitamin D and its derivatives should be withheld during treatment with Calcitriol to avoid possible additive effects and hypercalcemia (see WARNINGS ).

Uncontrolled intake of additional calcium-containing preparations should be avoided (see PRECAUTIONS. General ).

Magnesium-containing preparations (e. g. antacids) may cause hypermagnesemia and should therefore not be taken during therapy with Calcitriol by patients on chronic renal dialysis.

Carcinogenesis, Mutagenesis, Impairment of Fertility

Long-term studies in animals have not been conducted to evaluate the carcinogenic potential of Calcitriol. Calcitriol is not mutagenic in vitro in the Ames Test, nor is it genotoxic in vivo in the Mouse Micronucleus Test. No significant effects of Calcitriol on fertility and/or general reproductive performances were observed in a Segment I study in rats at doses of up to 0.3 mcg/kg (approximately 3 times the maximum recommended dose based on body surface area).

Pregnancy

Teratogenic Effects: Pregnancy Category C.

Calcitriol has been found to be teratogenic in rabbits when given at doses of 0.08 and 0.3 mcg/kg (approximately 2 and 6 times the maximum recommended dose based on mg/m 2 ). All 15 fetuses in 3 litters at these doses showed external and skeletal abnormalities. However, none of the other 23 litters (156 fetuses) showed external and skeletal abnormalities compared with controls.

Teratogenicity studies in rats at doses up to 0.45 mcg/kg (approximately 5 times maximum recommended dose based on mg/m 2 ) showed no evidence of teratogenic potential. There are no adequate and well-controlled studies in pregnant women. Calcitriol should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

In the rabbit, dosages of 0.3 mcg/kg/day (approximately 6 times maximum recommended dose based on surface area) administered on days 7 to 18 of gestation resulted in 19% maternal mortality, a decrease in mean fetal body weight and a reduced number of newborn surviving to 24 hours. A study of perinatal and postnatal development in rats resulted in hypercalcemia in the offspring of dams given Calcitriol at doses of 0.08 or 0.3 mcg/kg/day (approximately 1 and 3 times the maximum recommended dose based on mg/m 2 ), hypercalcemia and hypophosphatemia in dams given Calcitriol at a dose of 0.08 or 0.3 mcg/kg/day, and increased serum urea nitrogen in dams given Calcitriol at a dose of 0.3 mcg/kg/day. In another study in rats, maternal weight gain was slightly reduced at a dose of 0.3 mcg/kg/day (approximately 3 times the maximum recommended dose based on mg/m 2 ) administered on days 7 to 15 of gestation. The offspring of a woman administered 17 mcg/day to 36 mcg/day of Calcitriol (approximately 17 to 36 times the maximum recommended dose), during pregnancy manifested mild hypercalcemia in the first 2 days of life which returned to normal at day 3.

Nursing Mothers

Calcitriol from ingested Calcitriol Oral Solution may be excreted in human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions from Calcitriol in nursing infants, a mother should not nurse while taking Calcitriol.

Pediatric Use

Safety and effectiveness of Calcitriol in pediatric patients undergoing dialysis have not been established. The safety and effectiveness of Calcitriol in pediatric predialysis patients is based on evidence from adequate and well-controlled studies of Calcitriol in adults with predialysis chronic renal failure and additional supportive data from non-placebo controlled studies in pediatric patients. Dosing guidelines have not been established for pediatric patients under 1 year of age with hypoparathyroidism or for pediatric patients less than 6 years of age with pseudohypoparathyroidism (see DOSAGE AND ADMINISTRATION. Hypoparathyroidism ).

Oral doses of Calcitriol ranging from 10 to 55 ng/kg/day have been shown to improve calcium homeostasis and bone disease in pediatric patients with chronic renal failure for whom hemodialysis is not yet required (predialysis). Long-term Calcitriol therapy is well-tolerated by pediatric patients. The most common safety issues are mild, transient episodes of hypercalcemia, hyperphosphatemia, and increases in the serum calcium times phosphate (Ca x P) product which are managed effectively by dosage adjustment or temporary discontinuation of the vitamin D derivative.

Geriatric Use

Clinical studies of Calcitriol did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.

ADVERSE REACTIONS

Since Calcitriol is believed to be the active hormone which exerts vitamin D activity in the body, adverse effects are, in general, similar to those encountered with excessive vitamin D intake, i. e. hypercalcemia syndrome or calcium intoxication (depending on the severity and duration of hypercalcemia) (see WARNINGS ). Because of the short biological half-life of Calcitriol, pharmacokinetic investigations have shown normalization of elevated serum calcium within a few days of treatment withdrawal, i. e. much faster than in treatment with vitamin D 3 preparations.

The early and late signs and symptoms of vitamin D intoxication associated with hypercalcemia include:

Early: weakness, headache, somnolence, nausea, vomiting, dry mouth, constipation, muscle pain, bone pain, metallic taste, and anorexia, abdominal pain or stomach ache.

Late: polyuria, polydipsia, anorexia, weight loss, nocturia, conjunctivitis (calcific), pancreatitis, photophobia, rhinorrhea, pruritus, hyperthermia, decreased libido, elevated BUN, albuminuria, hypercholesterolemia, elevated SGOT (AST) and SGPT (ALT), ectopic calcification, nephrocalcinosis, hypertension, cardiac arrhythmias, dystrophy, sensory disturbances, dehydration, apathy, arrested growth, urinary tract infections, and, rarely, overt psychosis.

In clinical studies on hypoparathyroidism and pseudohypoparathyroidism, hypercalcemia was noted on at least one occasion in about 1 in 3 patients and hypercalciuria in about 1 in 7 patients. Elevated serum creatinine levels were observed in about 1 in 6 patients (approximately one half of whom had normal levels at baseline).

In concurrent hypercalcemia and hyperphosphatemia, soft-tissue calcification may occur; this can be seen radiographically (see WARNINGS ).

In patients with normal renal function, chronic hypercalcemia may be associated with an increase in serum creatinine (see PRECAUTIONS. General ).

Hypersensitivity reactions (pruritus, rash, urticaria, and very rarely severe erythematous skin disorders) may occur in susceptible individuals. One case of erythema multiforme and one case of allergic reaction (swelling of lips and hives all over body) were confirmed by rechallenge.

Overdosage

Administration of Calcitriol to patients in excess of their daily requirements can cause hypercalcemia, hypercalciuria and hyperphosphatemia. Since Calcitriol is a derivative of vitamin D, the signs and symptoms of overdose are the same for an overdose of vitamin D (see ADVERSE REACTIONS ). High intake of calcium and phosphate concomitant with Calcitriol may lead to similar abnormalities. The serum calcium times phosphate (Ca x P) product should not be allowed to exceed 70 mg 2 /dL 2. High levels of calcium in the dialysate bath may contribute to the hypercalcemia (see WARNINGS ).

Treatment of Hypercalcemia and Overdosage in Dialysis Patients and Hypoparathyroidism Patients:

General treatment of hypercalcemia (greater than 1 mg/dL above the upper limit of the normal range) consists of immediate discontinuation of Calcitriol therapy, institution of a low-calcium diet and withdrawal of calcium supplements. Serum calcium levels should be determined daily until normocalcemia ensues. Hypercalcemia frequently resolves in 2 to 7 days. When serum calcium levels have returned to within normal limits, Calcitriol therapy may be reinstituted at a dose of 0.25 mcg/day less than prior therapy. Serum calcium levels should be obtained at least twice weekly after all dosage changes and subsequent dosage titration. In dialysis patients, persistent or markedly elevated serum calcium levels may be corrected by dialysis against a calcium-free dialysate.

Treatment of Hypercalcemia and Overdosage in Predialysis Patients

If hypercalcemia ensues (greater than 1 mg/dL above the upper limit of the normal range), adjust dosage to achieve normocalcemia by reducing Calcitriol therapy from 0.5 mcg to 0.25 mcg daily. If the patient is receiving a therapy of 0.25 mcg daily, discontinue Calcitriol until patient becomes normocalcemic. Calcium supplements should also be reduced or discontinued. Serum calcium levels should be determined 1 week after withdrawal of calcium supplements. If serum calcium levels have returned to normal, Calcitriol therapy may be reinstituted at a dosage of 0.25 mcg/day if previous therapy was at a dosage of 0.5 mcg/day. If Calcitriol therapy was previously administered at a dosage of 0.25 mcg/day, Calcitriol therapy may be reinstituted at a dosage of 0.25 mcg every other day. If hypercalcemia is persistent at the reduced dosage, serum PTH should be measured. If serum PTH is normal, discontinue Calcitriol therapy and monitor patient in 3 months’ time.

Treatment of Hyperphosphatemia in Predialysis Patients

If serum phosphorus levels exceed 5 mg/dL to 5.5 mg/dL, a calcium-containing phosphate binding agent (i. e. calcium carbonate or calcium acetate) should be taken with meals. Serum phosphorus levels should be determined as described earlier (see PRECAUTIONS. Laboratory Tests ). Aluminum-containing gels should be used with caution as phosphate binding agents because of the risk of slow aluminum accumulation.

Treatment of Accidental Overdosage of Calcitriol

The treatment of acute accidental overdosage of Calcitriol should consist of general supportive measures. If drug ingestion is discovered within a relatively short time, induction of emesis or gastric lavage may be of benefit in preventing further absorption. If the drug has passed through the stomach, the administration of mineral oil may promote its fecal elimination. Serial serum electrolyte determinations (especially calcium), rate of urinary calcium excretion and assessment of electrocardiographic abnormalities due to hypercalcemia should be obtained. Such monitoring is critical in patients receiving digitalis. Discontinuation of supplemental calcium and a low-calcium diet are also indicated in accidental overdosage. Due to the relatively short duration of the pharmacological action of Calcitriol, further measures are probably unnecessary. Should, however, persistent and markedly elevated serum calcium levels occur, there are a variety of therapeutic alternatives which may be considered, depending on the patient’s underlying condition. These include the use of drugs such as phosphates and corticosteroids as well as measures to induce an appropriate forced diuresis. The use of peritoneal dialysis against a calcium-free dialysate has also been reported.

Calcitriol Dosage and Administration

The optimal daily dose of Calcitriol oral solution must be carefully determined for each patient. Calcitriol oral solution is administered orally as an oral solution (1 mcg/mL). Calcitriol therapy should always be started at the lowest possible dose and should not be increased without careful monitoring of serum calcium.

The effectiveness of Calcitriol therapy is predicated on the assumption that each patient is receiving an adequate but not excessive daily intake of calcium. Patients are advised to have a dietary intake of calcium at a minimum of 600 mg daily. The U. S. RDA for calcium in adults is 800 mg to 1200 mg. To ensure that each patient receives an adequate daily intake of calcium, the physician should either prescribe a calcium supplement or instruct the patient in proper dietary measures.

Because of improved calcium absorption from the gastrointestinal tract, some patients on Calcitriol oral solution may be maintained on a lower calcium intake. Patients who tend to develop hypercalcemia may require only low doses of calcium or no supplementation at all.

During the titration period of treatment with Calcitriol, serum calcium levels should be checked at least twice weekly. When the optimal dosage of Calcitriol has been determined, serum calcium levels should be checked every month (or as given below for individual indications). Samples for serum calcium estimation should be taken without a tourniquet.

Dialysis Patients

The recommended initial dose of Calcitriol is 0.25 mcg/day. If a satisfactory response in the biochemical parameters and clinical manifestations of the disease state is not observed, dosage may be increased by 0.25 mcg/day at 4 to 8 week intervals. During this titration period, serum calcium levels should be obtained at least twice weekly, and if hypercalcemia is noted, the drug should be immediately discontinued until normocalcemia ensues (see PRECAUTIONS. General ).

Phosphorus, magnesium, and alkaline phosphatase should be determined periodically.

Patients with normal or only slightly reduced serum calcium levels may respond to Calcitriol doses of 0.25 mcg every other day. Most patients undergoing hemodialysis respond to doses between 0.5 and 1 mcg/day.

Oral Calcitriol may normalize plasma ionized calcium in some uremic patients, yet fail to suppress parathyroid hyperfunction. In these individuals with autonomous parathyroid hyperfunction, oral Calcitriol may be useful to maintain normocalcemia, but has not been shown to be adequate treatment for hyperparathyroidism.

Hypoparathyroidism

The recommended initial dosage of Calcitriol is 0.25 mcg/day given in the morning. If a satisfactory response in the biochemical parameters and clinical manifestations of the disease is not observed, the dose may be increased at 2 to 4 week intervals. During the dosage titration period, serum calcium levels should be obtained at least twice weekly and, if hypercalcemia is noted, Calcitriol should be immediately discontinued until normocalcemia ensues (see PRECAUTIONS. General ). Careful consideration should also be given to lowering the dietary calcium intake. Serum calcium, phosphorus, and 24 hour urinary calcium should be determined periodically.

Most adult patients and pediatric patients age 6 years and older have responded to dosages in the range of 0.5 mcg to 2 mcg daily. Pediatric patients in the 1 to 5 year age group with hypoparathyroidism have usually been given 0.25 mcg to 0.75 mcg daily. The number of treated patients with pseudohypoparathyroidism less than 6 years of age is too small to make dosage recommendations.

Malabsorption is occasionally noted in patients with hypoparathyroidism; hence, larger doses of Calcitriol may be needed.

Predialysis Patients

The recommended initial dosage of Calcitriol is 0.25 mcg/day in adults and pediatric patients 3 years of age and older. This dosage may be increased if necessary to 0.5 mcg/day.

For pediatric patients less than 3 years of age, the recommended initial dosage of Calcitriol is 10 to 15 ng/kg/day.

How is Calcitriol Supplied

Calcitriol Oral Solution

1 mcg/mL oral solution is supplied as a clear, pale yellow solution. Each 15 mL amber glass bottle is supplied with 20 single-use, graduated oral dispensers.

NDC 0054-3120-41: Bottle of 15 mL

Store at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]

PROTECT FROM LIGHT.

REFERENCE

• Jones CL, et al. Comparisons between oral and intraperitoneal 1,25-dihydroxyvitamin D 3 therapy in children treated with peritoneal dialysis. Clin Nephrol. 1994; 42:44-49.

Distr. by: West-Ward

Eatontown, NJ 07724

Revised March 2016

PACKAGE/LABEL PRINCIPAL DISPLAY PANEL

Vytorin - Cholesterol Lowering, Zeklen

Cholesterol Lowering - Zeklen (Brand name: vytorin)

Vytorin (Ezetimibe/Simvastatin) is used for reducing total cholesterol, LDL cholesterol, and triglycerides and for increasing HDL cholesterol.

Vytorin is available in a 20 mg dosage ( 10 mg of ezetimibe and 10 mg of simvastatin) and in a 30 mg dosage (10 mg of ezetimibe, and 20 mg of simvastatin).

The recommended dose range of Vytorin is 10/10 mg to 10/80 mg, and it is administered once daily in the evening with or without food. Therapy is usually initiated with 10/20 mg daily, but individuals who need more than a 55% reduction in LDL cholesterol can be started on 10/40 mg daily.

Drug Class and Mechanism

Vytorin is a combination of ezetimibe (Zetia) and simvastatin (Zocor) that is used for treating high levels of cholesterol in the blood. Vytorin reduces total cholesterol and low density lipoprotein cholesterol while it increases high density lipoprotein cholesterol. The ezetimibe component of Vytorin lowers blood cholesterol by blocking the absorption of cholesterol, including dietary cholesterol, from the intestine. It does not affect the absorption of triglycerides. The simvastatin component of Vytorin belongs to a class of drugs called HMG-CoA reductase inhibitors, commonly called "statins". Statins reduce cholesterol by blocking an enzyme in the liver (HMG-CoA reductase) that produces cholesterol. Statins lower total and LDL cholesterol in the blood as well as triglycerides. They also increase HDL cholesterol. LDL cholesterol is believed to be an important cause of coronary artery disease. Lowering LDL cholesterol levels slows and may even reverse coronary artery disease. Raising HDL cholesterol levels also may slow down coronary artery disease. Vytorin was approved by the FDA in July, 2004.

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Vytorin should be stored at room temperature, 20-25 degrees C (68-77 degrees F).

Before taking ezetimibe/simvastatin, tell your doctor or pharmacist if you think you are allergic to it; or to other drugs called "statins"; or if you have any other allergies. This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: active liver disease. Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart disease, history of liver disease, kidney disease, underactive thyroid (hypothyroidism), poorly controlled diabetes, alcohol use. Developing severe muscle damage, which is rare, can sometimes lead to serious kidney problems (see the Side Effects section in this handout). This medication is usually temporarily stopped if you have any condition which can increase your risk of developing kidney problems. Before you stop taking your medication, notify your doctor immediately if you have any of the following conditions: major surgery, trauma, serious illness (e. g. sepsis or severe metabolic, endocrine, or electrolyte disorders), very low blood pressure, uncontrolled seizures. Limit alcoholic beverages. Daily use of alcohol may increase your chance for serious side effects. Caution is advised when using this drug in the elderly because they may be more sensitive to its side effects, especially muscle damage. This medication must not be used during pregnancy. If you become pregnant or think you may be pregnant, inform your doctor immediately. It is recommended that young girls and women of child-bearing age use effective birth control to prevent pregnancy while taking this drug. One of these drugs (simvastatin) may cause harm to your unborn child. It is not known if either drug passes into breast milk. A drug similar to simvastatin passes into breast milk, and because of this drug's potential risk of undesirable effects on a nursing infant, breast-feeding is not recommended while using ezetimibe/simvastatin. Consult your doctor before breast-feeding.

Possible Side Effects

Headache may occur. If this effect persists or worsens, notify your doctor or pharmacist promptly. This drug can sometimes cause muscle damage. Although uncommon, this may lead to very serious muscle damage called rhabdomyolysis, which in rare cases can be fatal. Seek immediate medical attention if you develop: muscle pain/tenderness/weakness (especially with fever or unusual tiredness). Tell your doctor immediately if any of these highly unlikely but very serious side effects occur: yellowing eyes and skin, dark urine, severe fatigue, stomach/abdominal pain, persistent nausea, change in the amount of urine. A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching, swelling, dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.

Do not share this medication with others. Laboratory and/or medical tests (e. g. blood cholesterol levels, liver function tests) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details. For best results, this product should be used along with exercise, a low-cholesterol or low-fat diet, and a weight-loss program if you are overweight. Also to help reduce your risk of heart attacks and strokes, check your blood pressure regularly, seek medical treatment if your blood pressure is high, and stop smoking. Consult your doctor for more details.

Vytorin (Ezetimibe/Simvastatin) is used for reducing total cholesterol, LDL cholesterol, and triglycerides and for increasing HDL cholesterol.

Vytorin is available in a 20 mg dosage ( 10 mg of ezetimibe and 10 mg of simvastatin) and in a 30 mg dosage (10 mg of ezetimibe, and 20 mg of simvastatin).

The recommended dose range of Vytorin is 10/10 mg to 10/80 mg, and it is administered once daily in the evening with or without food. Therapy is usually initiated with 10/20 mg daily, but individuals who need more than a 55% reduction in LDL cholesterol can be started on 10/40 mg daily.

Drug Class and Mechanism

Vytorin is a combination of ezetimibe (Zetia) and simvastatin (Zocor) that is used for treating high levels of cholesterol in the blood. Vytorin reduces total cholesterol and low density lipoprotein cholesterol while it increases high density lipoprotein cholesterol. The ezetimibe component of Vytorin lowers blood cholesterol by blocking the absorption of cholesterol, including dietary cholesterol, from the intestine. It does not affect the absorption of triglycerides. The simvastatin component of Vytorin belongs to a class of drugs called HMG-CoA reductase inhibitors, commonly called "statins". Statins reduce cholesterol by blocking an enzyme in the liver (HMG-CoA reductase) that produces cholesterol. Statins lower total and LDL cholesterol in the blood as well as triglycerides. They also increase HDL cholesterol. LDL cholesterol is believed to be an important cause of coronary artery disease. Lowering LDL cholesterol levels slows and may even reverse coronary artery disease. Raising HDL cholesterol levels also may slow down coronary artery disease. Vytorin was approved by the FDA in July, 2004.

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Vytorin should be stored at room temperature, 20-25 degrees C (68-77 degrees F).

Before taking ezetimibe/simvastatin, tell your doctor or pharmacist if you think you are allergic to it; or to other drugs called "statins"; or if you have any other allergies. This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: active liver disease. Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart disease, history of liver disease, kidney disease, underactive thyroid (hypothyroidism), poorly controlled diabetes, alcohol use. Developing severe muscle damage, which is rare, can sometimes lead to serious kidney problems (see the Side Effects section in this handout). This medication is usually temporarily stopped if you have any condition which can increase your risk of developing kidney problems. Before you stop taking your medication, notify your doctor immediately if you have any of the following conditions: major surgery, trauma, serious illness (e. g. sepsis or severe metabolic, endocrine, or electrolyte disorders), very low blood pressure, uncontrolled seizures. Limit alcoholic beverages. Daily use of alcohol may increase your chance for serious side effects. Caution is advised when using this drug in the elderly because they may be more sensitive to its side effects, especially muscle damage. This medication must not be used during pregnancy. If you become pregnant or think you may be pregnant, inform your doctor immediately. It is recommended that young girls and women of child-bearing age use effective birth control to prevent pregnancy while taking this drug. One of these drugs (simvastatin) may cause harm to your unborn child. It is not known if either drug passes into breast milk. A drug similar to simvastatin passes into breast milk, and because of this drug's potential risk of undesirable effects on a nursing infant, breast-feeding is not recommended while using ezetimibe/simvastatin. Consult your doctor before breast-feeding.

Possible Side Effects

Headache may occur. If this effect persists or worsens, notify your doctor or pharmacist promptly. This drug can sometimes cause muscle damage. Although uncommon, this may lead to very serious muscle damage called rhabdomyolysis, which in rare cases can be fatal. Seek immediate medical attention if you develop: muscle pain/tenderness/weakness (especially with fever or unusual tiredness). Tell your doctor immediately if any of these highly unlikely but very serious side effects occur: yellowing eyes and skin, dark urine, severe fatigue, stomach/abdominal pain, persistent nausea, change in the amount of urine. A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching, swelling, dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.

Do not share this medication with others. Laboratory and/or medical tests (e. g. blood cholesterol levels, liver function tests) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details. For best results, this product should be used along with exercise, a low-cholesterol or low-fat diet, and a weight-loss program if you are overweight. Also to help reduce your risk of heart attacks and strokes, check your blood pressure regularly, seek medical treatment if your blood pressure is high, and stop smoking. Consult your doctor for more details.

Imigrane 20mg Nasal Spray, Imigrane

IMIGRANE 20MG NASAL SPRAY

Transcript

Reporting of side effects If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at www. mhra. gov. uk/yellowcard. By reporting side effects you can help provide more information on the safety of this medicine.

5. HOW TO STORE IMIGRAN NASAL SPRAY EXPIRY DATE Do not use this medicine after the expiry date shown on the carton label. If your doctor tells you to stop taking this medicine, return any unused nasal spray to your pharmacist (chemist) for safe disposal. Only keep this medicine, if your doctor tells you to. Storing your medicine • KEEP THIS MEDICINE OUT OF THE SIGHT AND REACH OF CHILDREN. • Do not store above 30°C. Do not freeze. Protect from light. • You may want to carry your Imigran with you in case of a migraine attack. • Keep your nasal spray in the sealed pack provided. • Medicines should not be disposed of via waste water or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment

6. CONTENTS OF THE PACK AND OTHER INFORMATION What Imigran nasal spray contains Each pre-filled spray contains 20mg sumatriptan in 0.1ml aqueous solution as the active ingredient. Inactive ingredients are: potassium dihydrogen phosphate, dibasic sodium phosphate anhydrous, sulphuric acid, sodium hydroxide and purified water. What Imigran nasal spray looks like and contents of the pack Imigran is a clear pale yellow to dark yellow liqiud, in glass vial, which is held in a blue plastic holder with grey nose piece, in a single dose. Imigran is available in packs of two pre-filled nasal spray devices. Manufacturer and Licence Holder The nasal sprays are manufactured by GlaxoSmithKline Manufacturing S. p.A. Strada Provinciale Asolana, 90 43056 San Polo Di Torrile, Parme, Italy and are procured from within the EU and repackaged by the Product Licence Holder: Lexon (UK) Limited, Unit 18, Oxleasow Road, East Moons Moat, Redditch, Worcestershire, B98 0RE. If you have any questions or are not sure about anything, ask your doctor or pharmacist. They will have additional information about this medicine and will be able to advise you.

PL 15184/0766 - Imigran 20mg Nasal Spray

Imigran is a registered trademark of the GlaxoSmithKline Group of Companies. Leaflet revision date: 01/08/16

Blind or partially sighted? Is this leaflet hard to see or read? Phone Lexon (UK) Limited, Tel: 01527 505414 for help.

If you need more help or advice on migraine please contact the following national organisations: Migraine Action Association Unit 6 Oakley Hay Lodge Business Park Great Folds Road Great Oakley Northants NN18 9AS Telephone: 01536 461333 The Migraine Trust 55-56 Russell Square London WC1B 4HP Telephone: 020 7436 1336 You may well be able to find out more about prescribed medicines from books in public libraries. Migraine Action Association and The Migraine Trust are independent organisations and are not associated with Lexon (UK) Limited.

PATIENT INFORMATION LEAFLET

IMIGRAN 20MG NASAL SPRAY (sumatriptan) Read all of this leaflet carefully before you start taking this medicine because it contains important information for you. • Keep this leaflet. You may need to read it again. • If you have any further questions, ask your doctor or pharmacist. • This medicine has been prescribed for you only. Do not pass it on to others - it may harm them, even if their signs of illness are the same as yours. • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4. Your medicine is called Imigran 20mg Nasal Spray but will be referred to as Imigran throughout this leaflet. Please note that the leaflet also contains information about other strengths of the medicine, Imigran10mg.

What is in this leaflet 1. What Imigran is and what it is used for 2. What you need to know before you use Imigran nasal spray 3. How to use Imigran nasal spray 4. Possible side effects 5. How to store Imigran nasal spray 6. Contents of the pack and other information

1. WHAT IMIGRAN IS AND WHAT IT IS USED FOR Each Imigran nasal spray contains a single dose of sumatriptan, which belongs to a group of medicines called triptans (also known as 5-HT1 receptor agonists). Imigran nasal spray is used to treat migraine headache. Migraine symptoms may be caused by the temporary widening of blood vessels in the head. Imigran nasal spray is believed to reduce the widening of these blood vessels. This in turn helps to take away the headache and relieve other symptoms of a migraine attack, such as feeling or being sick (nausea or vomiting) and sensitivity to light and sound. 2. WHAT YOU NEED TO KNOW BEFORE YOU USE IMIGRAN NASAL SPRAY Don’t use Imigran: • If you’re allergic to sumatriptan, or any of the other ingredients of this medicine (listed in section 6). • If you have a heart problem such as narrowing of the arteries (Ischaemic heart disease) or chest pains (angina), or have already had a heart attack. • If you have circulation problems in your legs that cause cramp-like pains when you walk (peripheral vascular disease). • If you have had a stroke or a mini-stroke (also called a transient ischaemic attack or TIA). • If you have high blood pressure. You may be able to use Imigran if your high blood pressure is mild and is being treated. • If you have serious liver disease. • With other migraine medicines, including those which contain ergotamine, or similar medicines such as methysergide or any triptan/5-HT1 receptor agonist (medicines which are also used for treating migraine). • With anti-depressants called MAOIs (monoamine oxidase inhibitors), or if you have taken these medicines in the last 2 weeks.

If any of these apply to you: Tell your doctor, and don’t use Imigran nasal spray. Take special care with Imigran Talk to your doctor or pharmacist before using Imigran. If you have any extra risk factors If you are a heavy smoker, or are using nicotine replacement therapy, and especially • If you are a man aged over 40, or • If you are a woman who has been through the menopause.

In very rare cases, people have developed serious heart conditions after using Imigran, even though they had no signs of heart disease before. If any of the points above applies to you it could mean you have a greater risk of developing heart disease - so: Tell your doctor so that your heart function can be checked before Imigran is prescribed for you. If you have a history of fits (seizures) Or if you have other conditions which might make it more likely that you’ll have a fit – for example, a head injury or alcoholism. Tell your doctor so that you can be supervised more closely. If you have liver or kidney disease Tell your doctor so that you can be supervised more closely. If you are allergic to antibiotics called sulphonamides If so, you may also be allergic to Imigran. If you know you are allergic to an antibiotic but you are not sure whether it is a sulphonamide: Tell your doctor or pharmacist before using Imigran. If you are taking anti-depressants called SSRIs (Selective Serotonin Reuptake Inhibitors) or SNRIs (Serotonin Noradrenaline Reuptake Inhibitors) Tell your doctor or pharmacist before using Imigran. Also see Other medicines and Imigran, below. If you use Imigran frequently Using Imigran too often may make your headaches worse. Tell your doctor if this applies to you. He or she may recommend you stop using Imigran. If you feel pain or tightness in your chest after you use Imigran These effects may be intense but they usually pass quickly. If they don’t pass quickly, or they become severe: Get medical help immediately. Section 4 of this leaflet has more information about these possible side effects.

Other medicines and Imigran Tell your doctor or pharmacist if you’re taking, have recently taken or might take any other medicines. This includes any herbal products or medicines you’ve bought without a prescription. Some medicines must not be taken with Imigran and others may cause adverse effects if they’re taken with Imigran. You must tell your doctor if you are taking: • ergotamine also used to treat migraine, or similar medicines such as methysergide (see Section 2). Don’t use Imigran at the same time as these medicines. Stop taking these medicines at least 24 hours before using Imigran. Don’t take any medicines which contain ergotamine or compounds similar to ergotamine again for at least 6 hours after using Imigran. • other triptans/5-HT1 receptor agonists (such as naratriptan, rizatriptan, zolmitriptan), also used to treat migraine, (see Section 2). Don’t use Imigran at the same time as these medicines. Stop taking these medicines at least 24 hours before using Imigran. Don’t take another triptan/5-HT1 receptor agonist again for at least 24 hours after using Imigran. • SSRIs (Selective Serotonin Reuptake Inhibitors) or SNRIs (Serotonin Noradrenaline Reuptake Inhibitors) used to treat depression. Using Imigran with these medicines can cause serotonin syndrome (a collection of symptoms which can include restlessness, confusion, sweating, hallucinations, increased reflexes, muscle spasms, shivering, increased heartbeat and shaking). Tell your doctor immediately if you are affected in this way. • MAOIs (monoamine oxidase inhibitors) used to treat depression. Don’t use Imigran if you have taken these in the last 2 weeks. • St John’s Wort (Hypericum perforatum). Taking herbal remedies that contain St John’s Wort while you are using Imigran may make side effects more likely. Pregnancy and breast-feeding • If you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine. There is only limited information about the safety of Imigran for pregnant women, though up until now there is no evidence of any increased risk of birth defects. Your doctor will discuss with you whether or not you should use Imigran while you are pregnant. • Don’t breast-feed your baby for 12 hours after using Imigran. If you express any breast milk during this time, discard the milk and don’t give it to your baby.

How to use the nasal spray

How much to use Adults aged 18 to 65 The usual dose for adults aged 18 to 65 is one Imigran 20 mg spray into just one nostril. But one Imigran 10 mg spray into one nostril is enough for some people. Don’t use more than two sprays in 24 hours.

Adolescents aged 12 to 17 The usual dose for adolescents aged 12 to 17 is one Imigran 10 mg spray into one nostril.

Children under 12 Imigran nasal spray is not recommended for children under 12 years old.

3. HOW TO USE IMIGRAN NASAL SPRAY Only use Imigran after your migraine headache begins

There’s a step-by-step guide to using the spray at the end of this section.

3 Blow your nose if it feels blocked, or if you have a cold. 4 Hold the nasal spray gently with your fingers and thumb, as shown in picture A. Don’t press the blue plunger yet.

When to use Imigran • It’s best to use Imigran as soon as you feel a migraine coming on, although it can be used at any time during an attack. If your symptoms start to come back You can use a second Imigran nasal spray after 2 hours, but don’t use more than two sprays in 24 hours.

5 Block one nostril by pressing a finger firmly on the side of your nose. It doesn’t matter which nostril you choose.

If the first spray has no effect • Don’t use a second spray, or any other Imigran preparation for the same attack. If Imigran doesn’t give you any relief: Ask your doctor or pharmacist for advice. If you use more Imigran than you should Don’t use more than two Imigran nasal sprays in 24 hours. Using too much Imigran could make you ill. If you have used more than two sprays in 24 hours: Contact your doctor for advice.

6 Put the nozzle of the nasal spray into the other nostril, as far as feels comfortable about 1 cm or 1/2 inch (picture B). Breathe out gently through your mouth. Hold your head upright and close your mouth.

Step-by-step guide to using your Imigran nasal spray

The nozzle The part that you put into your nostril. The spray comes out of a tiny hole in the top The finger-grip Hold this when you use the spray

7 Start to breathe in gently through your nose. As you breathe in: Press the blue plunger firmly with your thumb. The plunger may feel a bit stiff and you may hear it click. Keep breathing in while spraying (picture C). 8 Remove the spray and remove your finger from the side of your nose. Keep your head upright for 10-20 seconds, breathing gently in through your nose and out through your mouth. This helps the medicine stay in your nose. Your nose may feel wet inside and you may notice a slight taste after using the spray - this is normal and will soon pass. 9 Your nasal spray is now empty. Throw it away safely and hygienically.

The blue plunger

Press this to spray the whole dose into your nostril in one go. This only works once - don’t press the plunger until you have put the nozzle into your nostril or you will lose the dose

Allergic reaction: get doctor’s help straight away The following side effects have occurred but their frequency is not known. • The signs of allergy include rash, hives (itchy rash); wheezing; swollen eyelids, face or lips; complete collapse.

Very common side effects (affect more than 1 in 10 people) • Unpleasant taste. Common side effects (affect up to 1 in 10 people) • Heaviness, pressure, tightness or pain in the chest, throat or other parts of the body, or feelings of unusual sensations, including numbness, tingling and warmth or cold. These effects may be intense but generally pass quickly. If these effects continue or become severe (especially the chest pain): Get medical help urgently. In a very small number of people these symptoms can be caused by a heart attack. Other common side effects include: Irritation or burning sensation in the nose or throat; nose bleeds. • Feeling sick (nausea) or being sick (vomiting), although this may be due to the migraine itself. • Tiredness or drowsiness. • Dizziness, feeling weak, or getting hot flushes. • Temporary increase in blood pressure. • Shortness of breath. • Aching muscles.

If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

Don’t open a blister until you are ready to use a spray. Each spray is sealed in a blister to keep it clean and safe. If you carry a spray without a blister, or in an open blister, it may not work properly when you need it. Each spray contains just one dose of Imigran. Don’t press the plunger too soon or you will lose the dose.

4. POSSIBLE SIDE EFFECTS Like all medicines, this medicine can cause side effects, but not everybody gets them. Some symptoms may be caused by the migraine itself. Adverse events reported in adults have also been observed in adolescents. These include very rare reports of heart attacks.

If you get any of these symptoms soon after using Imigran: Don’t use any more. Contact a doctor straight away.

Older people (aged over 65) • Imigran nasal spray is not recommended for people aged over 65.

Don’t use Imigran to try to prevent an attack. Always use this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure.

2 Get into a comfortable position. You may prefer to sit down.

Imigran nasal spray has three parts: Driving and using machines Either the symptoms of migraine or your medicine may make you drowsy. If you are affected, don’t drive or operate machinery.

1 Remove the nasal spray from the blister packaging just before you want to use it.

Very rare side effects (affect up to 1 in 10,000 people) • Liver function changes. If you have a blood test to check your liver function, tell your doctor or nurse that you are using Imigran. Some patients may have the following side effects but it is not known how often they occur • Seizures/fits, tremors, muscle spasm, neck stiffness. • Visual disturbances such as flickering, reduced vision, double vision loss of vision and in some cases even permanent defects (although these may be due to the migraine attack itself). • Heart problems, where your heart beat may go faster, slower or change rhythm, chest pains (angina) or heart attack. • Pale blue-tinged skin and/or pain in your fingers, toes, ears, nose or jaw in response to cold or stress (Raynaud’s phenomenon). • Feeling faint (blood pressure may go down). • Pain in the lower left side of the stomach and bloody diarrhoea (ischaemic colitis). • Diarrhoea. • Pain in the joints. • Feeling anxious. • Excessive sweating.

Reporting of side effects If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at www. mhra. gov. uk/yellowcard. By reporting side effects. you help provide more information on the safety of this medicine. 5. HOW TO STORE IMIGRANE NASAL SPRAY EXPIRY DATE Do not use this medicine after the expiry date shown on the carton label. If your doctor tells you to stop taking this medicine, return any unused nasal spray to your pharmacist (chemist) for safe disposal. Only keep this medicine, if your doctor tells you to. Storing your medicine • KEEP THIS MEDICINE OUT OF THE SIGHT AND REACH OF CHILDREN. • Do not store above 30°C. Do not freeze. Protect from light. • You may want to carry your Imigrane with you in case of a migraine attack. • Keep your nasal spray in the sealed pack provided. • Medicines should not be disposed of via waste water or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment

6. CONTENTS OF THE PACK AND OTHER INFORMATION What Imigrane nasal spray contains Each pre-filled spray contains 20mg sumatriptan in 0.1ml aqueous solution as the active ingredient. Inactive ingredients are: potassium dihydrogen phosphate, dibasic sodium phosphate anhydrous, sulphuric acid, sodium hydroxide and purified water. What Imigrane nasal spray looks like and contents of the pack Imigrane is a clear pale yellow to dark yellow liqiud, in glass vial, which is held in a blue plastic holder with grey nose piece, in a single dose. Imigrane is available in packs of two pre-filled nasal spray devices. Manufacturer and Licence Holder The nasal sprays are manufactured by GlaxoSmithKline Manufacturing S. p.A. Strada Provinciale Asolana, 90 43056 San Polo Di Torrile, Parme, Italy and are procured from within the EU and repackaged by the Product Licence Holder: Lexon (UK) Limited, Unit 18, Oxleasow Road, East Moons Moat, Redditch, Worcestershire, B98 0RE. If you have any questions or are not sure about anything, ask your doctor or pharmacist. They will have additional information about this medicine and will be able to advise you.

PL 15184/0766 - Imigrane 20mg Nasal Spray

Imigrane is a registered trademark of the GlaxoSmithKline Group of Companies. Leaflet revision date: 01/08/16

Blind or partially sighted? Is this leaflet hard to see or read? Phone Lexon (UK) Limited, Tel: 01527 505414 for help.

If you need more help or advice on migraine please contact the following national organisations: Migraine Action Association Unit 6 Oakley Hay Lodge Business Park Great Folds Road Great Oakley Northants NN18 9AS Telephone: 01536 461333 The Migraine Trust 55-56 Russell Square London WC1B 4HP Telephone: 020 7436 1336 You may well be able to find out more about prescribed medicines from books in public libraries. Migraine Action Association and The Migraine Trust are independent organisations and are not associated with Lexon (UK) Limited.

PATIENT INFORMATION LEAFLET

Imigrane 20MG NASAL SPRAY (sumatriptan) Read all of this leaflet carefully before you start taking this medicine because it contains important infromation for you. • Keep this leaflet. You may need to read it again. • If you have any further questions, ask your doctor or pharmacist (chemist). • This medicine has been prescribed for you only. Do not pass it on to others - it may harm them, even if their signs of illness are the same as yours. • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4. Your medicine is called Imigrane 20mg Nasal Spray but will be referred to as Imigrane throughout this leaflet. Please note that the leaflet also contains information about other strengths of the medicine, Imigrane10mg.

What is in this leaflet 1. What Imigrane is and what it is used for 2. What you need to know before you use Imigrane nasal spray 3. How to use Imigrane nasal spray 4. Possible side effects 5. How to store Imigrane nasal spray 6. Contents of the pack and other infromation

1. WHAT IMIGRANE IS AND WHAT IT IS USED FOR Each Imigrane nasal spray contains a single dose of sumatriptan, which belongs to a group of medicines called triptans (also known as 5-HT1 receptor agonists). Imigrane nasal spray is used to treat migraine headache. Migraine symptoms may be caused by the temporary widening of blood vessels in the head. Imigrane nasal spray is believed to reduce the widening of these blood vessels. This in turn helps to take away the headache and relieve other symptoms of a migraine attack, such as feeling or being sick (nausea or vomiting) and sensitivity to light and sound. 2. WHAT YOU NEED TO KNOW BEFORE YOU USE IMIGRANE NASAL SPRAY Don’t use Imigrane: • If you’re allergic to sumatriptan, or any of the other ingredients of this medicine (listed in section 6). • If you have a heart problem such as narrowing of the arteries (Ischaemic heart disease) or chest pains (angina), or have already had a heart attack. • If you have circulation problems in your legs that cause cramp-like pains when you walk (peripheral vascular disease). • If you have had a stroke or a mini-stroke (also called a transient ischaemic attack or TIA). • If you have high blood pressure. You may be able to use Imigrane if your high blood pressure is mild and is being treated. • If you have serious liver disease. • With other migraine medicines, including those which contain ergotamine, or similar medicines such as methysergide or any triptan/5-HT1 receptor agonist (medicines which are also used for treating migraine). • With anti-depressants called MAOIs (monoamine oxidase inhibitors), or if you have taken these medicines in the last 2 weeks.

If any of these apply to you: Tell your doctor, and don’t use Imigrane nasal spray. Take special care with Imigrane Talk to your doctor or pharmacist before using Imigrane. If you have any extra risk factors If you are a heavy smoker, or are using nicotine replacement therapy, and especially • If you are a man aged over 40, or • If you are a woman who has been through the menopause.

In very rare cases, people have developed serious heart conditions after using Imigrane, even though they had no signs of heart disease before. If any of the points above applies to you it could mean you have a greater risk of developing heart disease - so: Tell your doctor so that your heart function can be checked before Imigrane is prescribed for you. If you have a history of fits (seizures) Or if you have other conditions which might make it more likely that you’ll have a fit – for example, a head injury or alcoholism. Tell your doctor so that you can be supervised more closely. If you have liver or kidney disease Tell your doctor so that you can be supervised more closely. If you are allergic to antibiotics called sulphonamides If so, you may also be allergic to Imigrane. If you know you are allergic to an antibiotic but you are not sure whether it is a sulphonamide: Tell your doctor or pharmacist before using Imigrane. If you are taking anti-depressants called SSRIs (Selective Serotonin Reuptake Inhibitors) or SNRIs (Serotonin Noradrenaline Reuptake Inhibitors) Tell your doctor or pharmacist before using Imigrane. Also see Other medicines and Imigrane, below. If you use Imigrane frequently Using Imigrane too often may make your headaches worse. Tell your doctor if this applies to you. He or she may recommend you stop using Imigrane. If you feel pain or tightness in your chest after you use Imigrane These effects may be intense but they usually pass quickly. If they don’t pass quickly, or they become severe: Get medical help immediately. Section 4 of this leaflet has more information about these possible side effects.

Other medicines and Imigrane Tell your doctor or pharmacist if you’re taking, have recently taken or might take any other medicines. This includes any herbal products or medicines you’ve bought without a prescription. Some medicines must not be taken with Imigrane and others may cause adverse effects if they’re taken with Imigrane. You must tell your doctor if you are taking: • ergotamine also used to treat migraine, or similar medicines such as methysergide (see Section 2). Don’t use Imigrane at the same time as these medicines. Stop taking these medicines at least 24 hours before using Imigrane. Don’t take any medicines which contain ergotamine or compounds similar to ergotamine again for at least 6 hours after using Imigrane. • other triptans/5-HT1 receptor agonists (such as naratriptan, rizatriptan, zolmitriptan), also used to treat migraine, (see Section 2). Don’t use Imigrane at the same time as these medicines. Stop taking these medicines at least 24 hours before using Imigrane. Don’t take another triptan/5-HT1 receptor agonist again for at least 24 hours after using Imigrane. • SSRIs (Selective Serotonin Reuptake Inhibitors) or SNRIs (Serotonin Noradrenaline Reuptake Inhibitors) used to treat depression. Using Imigrane with these medicines can cause serotonin syndrome (a collection of symptoms which can include restlessness, confusion, sweating, hallucinations, increased reflexes, muscle spasms, shivering, increased heartbeat and shaking). Tell your doctor immediately if you are affected in this way. • MAOIs (monoamine oxidase inhibitors) used to treat depression. Don’t use Imigrane if you have taken these in the last 2 weeks. • St John’s Wort (Hypericum perforatum). Taking herbal remedies that contain St John’s Wort while you are using Imigrane may make side effects more likely. Pregnancy and breast-feeding If you are pregnant, think you may be prenant or are planning to have a baby, ask your doctor for advice before taking this medicine. There is only limited information about the safety of Imigrane for pregnant women, though up until now there is no evidence of any increased risk of birth defects. Your doctor will discuss with you whether or not you should use Imigrane while you are pregnant. • Don’t breast-feed your baby for 12 hours after using Imigrane. If you express any breast milk during this time, discard the milk and don’t give it to your baby.

How to use the nasal spray

How much to use Adults aged 18 to 65 The usual dose for adults aged 18 to 65 is one Imigrane 20 mg spray into just one nostril. But one Imigrane 10 mg spray into one nostril is enough for some people. Don’t use more than two sprays in 24 hours.

Adolescents aged 12 to 17 The usual dose for adolescents aged 12 to 17 is one Imigrane 10 mg spray into one nostril.

Children under 12 Imigrane nasal spray is not recommended for children under 12 years old.

1 Remove the nasal spray from the blister packaging just before you want to use it. 2 Get into a comfortable position. You may prefer to sit down. 3 Blow your nose if it feels blocked, or if you have a cold. 4 Hold the nasal spray gently with your fingers and thumb, as shown in picture A. Don’t press the blue plunger yet.

When to use Imigrane It’s best to use Imigrane as soon as you feel a migraine coming on, although it can be used at any time during an attack.

5 Block one nostril by pressing a finger firmly on the side of your nose. It doesn’t matter which nostril you choose.

If the first spray has no effect • Don’t use a second spray, or any other Imigrane preparation for the same attack. If Imigrane doesn’t give you any relief: - Ask your doctor or pharmacist for advice. If you use more Imigrane than you should Don’t use more than two Imigrane nasal sprays in 24 hours. Using too much Imigrane could make you ill. If you have used more than two sprays in 24 hours: Contact your doctor for advice.

If you have any further question on the use of this medicine, ask your doctor or pharmacist.

6 Put the nozzle of the nasal spray into the other nostril, as far as feels comfortable about 1 cm or 1/2 inch (picture B). Breathe out gently through your mouth. Hold your head upright and close your mouth.

Driving and using machines Either the symptoms of migraine or your medicine may make you drowsy. If you are affected, don’t drive or operate machinery. 3. HOW TO USE IMIGRANE NASAL SPRAY Only use Imigrane after your migraine headache begins Don’t use Imigrane to try to prevent an attack.

Step-by-step guide to using your Imigran nasal spay Don’t open a blister until you are ready to use a spray. Each spray is sealed in a blister to keep it clean and safe. If you carry a spray without a blister, or in an open blister, it may not work properly when you need it. Each spray contains just one dose of Imigrane. Don’t press the plunger too soon or you will lose the dose. Imigrane nasal spray has three parts: The nozzle The part that you put into your nostril. The spray comes out of a tiny hole in the top The finger-grip Hold this when you use the spray

Always use this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure. There’s a step-by-step guide to using the spray at the end of this section.

The blue plunger

Press this to spray the whole dose into your nostril in one go. This only works once - don’t press the plunger until you have put the nozzle into your nostril or you will lose the dose

Allergic reaction: get doctor’s help straight away The following side effects have occurred but their exact frequency is not known. • The signs of allergy include rash, hives (itchy rash); wheezing; swollen eyelids, face or lips; complete collapse. If you get any of these symptoms soon after using Imigrane: Don’t use any more. Contact a doctor straight away.

Older people (aged over 65) • Imigrane nasal spray is not recommended for people aged over 65.

If your symptoms start to come back • You can use a second Imigrane nasal spray after 2 hours, but don’t use more than two sprays in 24 hours.

4. POSSIBLE SIDE EFFECTS Like all medicines, Imigrane nasal spray can cause side effects, but not everybody gets them. Some symptoms may be caused by the migraine itself. Adverse events reported in adults have also been observed in adolescents. These include very rare reports of heart attacks.

Very common side effects (affect more than 1 in 10 people) • Unpleasant taste. Common side effects (affect up to 1 in 10 people) • Heaviness, pressure, tightness or pain in the chest, throat or other parts of the body, or feelings of unusual sensations, including numbness, tingling and warmth or cold. These effects may be intense but generally pass quickly. If these effects continue or become severe (especially the chest pain): Get medical help urgently. In a very small number of people these symptoms can be caused by a heart attack. Other common side effects include: Irritation or burning sensation in the nose or throat; nose bleeds. • Feeling sick (nausea) or being sick (vomiting), although this may be due to the migraine itself. • Tiredness or drowsiness. • Dizziness, feeling weak, or getting hot flushes. • Temporary increase in blood pressure. • Shortness of breath. • Aching muscles.

Very rare side effects (affect up to 1 in 10,000 people) • Liver function changes. If you have a blood test to check your liver function, tell your doctor or nurse that you are using Imigrane. 7 Start to breathe in gently through your nose. As you breathe in: Press the blue plunger firmly with your thumb. The plunger may feel a bit stiff and you may hear it click. Keep breathing in while spraying (picture C). 8 Remove the spray and remove your finger from the side of your nose. Keep your head upright for 10-20 seconds, breathing gently in through your nose and out through your mouth. This helps the medicine stay in your nose. Your nose may feel wet inside and you may notice a slight taste after using the spray - this is normal and will soon pass. 9 Your nasal spray is now empty. Throw it away safely and hygienically.

Some patients may have the following side effects but it is not known how often they occur • Seizures/fits, tremors, muscle spasm, neck stiffness. • Visual disturbances such as flickering, reduced vision, double vision, loss of vision and in some cases even permanent defects (although these may be due to the migraine attack itself). • Heart problems, where your heart beat may go faster, slower or change rhythm, chest pains (angina) or heart attack. • Pale blue-tinged skin and/or pain in your fingers, toes, ears, nose or jaw in response to cold or stress (Raynaud’s phenomenon). • Feeling faint (blood pressure may go down). • Pain in the lower left side of the stomach and bloody diarrhoea (ischaemic colitis). • Diarrhoea. • Pain in the joints. • Feeling anxious. • Excessive sweating.

Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

Elixifilin, Elixifilin

Preventing and treating symptoms and blockage of airway due to asthma or other lung diseases (eg, emphysema, bronchitis). It may also be used for other conditions as determined by your doctor.

Quibron-T is a xanthine derivative. It works by relaxing the muscle around the airways in the lungs, which allows them to widen and makes breathing easier. It also improves contraction of the diaphragm (the major breathing muscle) and decreases the response of the airways to irritants.

Use Quibron-T as directed by your doctor. Check the label on the medicine for exact dosing instructions. This medicine may be taken on an empty stomach or with food. Try to take this medicine every day at evenly spaced times. If you have questions about the best time to take it, ask your pharmacist.

Some foods may change the effectiveness or increase the side effects of Quibron-T. Talk to your doctor about how you should take Quibron-T with regard to food. Do not suddenly change your diet or eating habits without first checking with your doctor. Take Quibron-T at evenly spaced times throughout the day. Taking Quibron-T at the same time each day will help you remember to take it. Contact your doctor with any questions or concerns about the best way to take Quibron-T. If you miss a dose of Quibron-T, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Quibron-T.

Use Quibron-T as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Store at room temperature away from sunlight and moisture.

Active Ingredient: Theophylline

Do NOT use Quibron-T if:

you are allergic to any ingredient in Quibron-T, similar medicines (eg, aminophylline), or xanthines (eg, caffeine, chocolate)

you are using large amounts of other products that contain xanthine (such as chocolate or caffeinated drinks)

you are taking dipyridamole intravenously (IV), febuxostat, halothane, or St. John's wort

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Quibron-T. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of heart problems (eg, congestive heart failure, cor pulmonale), an irregular heartbeat, liver problems (eg, cirrhosis, hepatitis), viral infection, thyroid problems, increased acid levels in the body, brain or nerve problems, or seizures (eg, epilepsy)

if you are in shock or have a fever, an ulcer, a severe infection, cystic fibrosis, or fluid in the lungs (pulmonary edema)

if you smoke, are stopping or starting smoking, or are exposed to the smoke from cigarettes or marijuana

if you are in the last 3 months of pregnancy

Important safety information:

Drinking alcohol may increase the risk of side effects of Quibron-T. Talk to your doctor before drinking alcohol while you are taking Quibron-T.

Tell your doctor or dentist that you take Quibron-T before you receive any medical or dental care, emergency care, or surgery.

Do not take more than the recommended dose or use more often than prescribed without checking with your doctor. If your symptoms become worse, contact your doctor.

Carry an ID card at all times that says you take Quibron-T.

Avoid large amounts of food or drink that have caffeine (eg, coffee, tea, cocoa, cola, chocolate).

Notify your doctor if you develop a new illness, especially if it is accompanied by fever; if a chronic illness becomes worse; or if you start or stop smoking cigarettes or marijuana.

Tell your doctor if another doctor prescribes a new medicine or tells you to stop using a medicine that you have already been taking. Tell your doctor if you start or stop any medicine, either prescription or over the counter.

Quibron-T will not stop an asthma attack once one has started. Be sure to always carry appropriate rescue medicine (eg, bronchodilator inhaler) with you in case of an asthma attack.

If you have more than one doctor, be sure to tell each of your doctors that you are taking Quibron-T.

Diabetes patients - Quibron-T may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

Quibron-T may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Quibron-T.

Lab tests, including blood theophylline levels, may be performed while you use Quibron-T. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Quibron-T with caution in the ELDERLY; they may be more sensitive to its effects.

Caution is advised when using Quibron-T in CHILDREN, especially children younger than 1 year old; they may be more sensitive to its effects. Children may be more likely to experience mild, temporary behavior changes.

PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor.

You will need to discuss the benefits and risks of using Quibron-T while you are pregnant. Quibron-T is found in breast milk. If you are or will be breast-feeding while you use Quibron-T, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Irritability; mild, temporary caffeine-like effects (eg, headache, nausea, diarrhea, trouble sleeping); mild, temporary changes in behavior; restlessness; temporary increased urination.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; dizziness; fast breathing; fast or irregular heartbeat; heart rhythm problems; seizures; severe or persistent nausea, diarrhea, or headache; sleeplessness; tremors; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects.

Cilostazol Medical Facts From, Cilost

cilostazol

What is cilostazol?

Cilostazol is a vasodilator that works by relaxing the muscles in your blood vessels to help them dilate (widen). Cilostazol dilates arteries that supply blood to your legs. Cilostazol also improves circulation by keeping platelets in the blood from sticking together and clotting.

Cilostazol is used to treat the symptoms of intermittent claudication. This condition causes reduced blood flow to the legs, leading to pain while walking. Cilostazol improves your ability to walk longer distances without pain.

Cilostazol may also be used for purposes not listed in this medication guide.

What is the most important information I should know about cilostazol?

Do not take cilostazol if you have congestive heart failure.

What should I discuss with my healthcare provider before taking cilostazol?

Do not take cilostazol if you have congestive heart failure. Cilostazol can make this condition worse.

To make sure cilostazol is safe for you, tell your doctor if you have:

heart disease; or

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether cilostazol passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

How should I take cilostazol?

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Cilostazol is usually taken twice a day on an empty stomach, at least 30 minutes before or 2 hours after breakfast or dinner.

Take the medicine at the same time each day.

It may take up to 12 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve after 4 weeks of treatment.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking cilostazol?

Grapefruit and grapefruit juice may interact with cilostazol and lead to unwanted side effects. Discuss the use of grapefruit products with your doctor.

Cilostazol side effects

Get emergency medical help if you have signs of an allergic reaction . hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

chest pain, pounding heartbeats or fluttering in your chest;

a light-headed feeling, like you might pass out;

fever, chills, body aches, flu symptoms;

bloody urine, painful urination;

shortness of breath, even with mild exertion; or

swelling of your ankles or feet.

Common side effects may include:

diarrhea, abnormal bowel movements;

upset stomach; or

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Cilostazol dosing information

Usual Adult Dose for Intermittent Claudication:

100 mg orally twice a day administered at least 30 minutes before or 2 hours after breakfast and dinner.

What other drugs will affect cilostazol?

Tell your doctor about all your current medicines and any you start or stop using, especially:

omeprazole (Prilosec) or esomeprazole (Nexium);

an antidepressant--fluoxetine, fluvoxamine, nefazodone;

an antibiotic--clarithromycin, ciprofloxacin, erythromycin, telithromycin;

antifungal medicine--fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole;

heart medication--diltiazem, nicardipine, quinidine, verapamil; or

antiviral medicine to treat hepatitis C or HIV/AIDS--atazanavir, boceprevir, cobicistat, darunavir (when given with ritonavir), delavirdine, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir, telaprevir.

This list is not complete. Other drugs may interact with cilostazol, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

More about cilostazol

Consumer resources

Professional resources

Related treatment guides

Where can I get more information?

Your pharmacist can provide more information about cilostazol.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 4.01. Revision Date: 2015-04-09, 9:39:56 AM.

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Leutrol Generic Name Zileuton Online, Leutrol

Leutrol General Information

Leutrol - Pharmacology:

Leukotrienes are substances that induce numerous biological effects including augmentation of neutrophil and eosinophil migration, neutrophil and monocyte aggregation, leukocyte adhesion, increased capillary permeability, and smooth muscle contraction. These effects contribute to inflammation, edema, mucus secretion, and bronchoconstriction in the airways of asthmatic patients. Leutrol relieves such symptoms through its selective inhibition of 5-lipoxygenase, the enzyme that catalyzes the formation of leukotrienes from arachidonic acid. Specifically, it inhibits leukotriene LTB4, LTC4, LTD4, and LTE4 formation. Both the R(+) and S(-) enantiomers are pharmacologically active as 5-lipoxygenase inhibitors in in vitro systems.

Leutrol for patients

Patients should be told that:

ZYFLO is indicated for the chronic treatment of asthma and should be taken regularly as prescribed, even during symptom-free periods.

ZYFLO is not a bronchodilator and should not be used to treat acute episodes of asthma.

When taking ZYFLO, they should not decrease the dose or stop taking any other antiasthma medications unless instructed by a physician.

While using ZYFLO, medical attention should be sought if short-acting bronchodilators are needed more often than usual, or if more than the maximum number of inhalations of short-acting bronchodilator treatment prescribed for a 24-hour period are needed.

The most serious side effect of ZYFLO is elevation of liver enzyme tests and that, while taking ZYFLO, they must return for liver enzyme test monitoring on a regular basis. If they experience signs and/or symptoms of liver dysfunction (e. g. right upper quadrant pain, nausea, fatigue, lethargy, pruritus, jaundice, or "flu-like" symptoms), they should contact their physician immediately.

ZYFLO can interact with other drugs and that, while taking ZYFLO, they should consult their doctor before starting or stopping any prescription or non-prescription medicines.

A patient leaflet is included with the tablets.

This description is suitable for active ingredient Zileuton

Leutrol Interactions

In a drug-interaction study in 16 healthy volunteers, co-administration of multiple doses of zileuton (800 mg every 12 hours) and theophylline (200 mg every 6 hours) for 5 days resulted in a significant decrease (approximately 50%) in steady-state clearance of theophylline, an approximate doubling of theophylline A. C. and an increase in theophylline C max (by 73%). The elimination half-life of theophylline was increased by 24%. Also, during co-administration, theophylline-related adverse events were observed more frequently than after theophylline alone. Upon initiation of ZYFLO in patients receiving theophylline, the theophylline dosage should be reduced by approximately one-half and plasma theophylline concentrations monitored. Similarly, when initiating therapy with theophylline in a patient receiving ZYFLO, the maintenance dose and/or dosing interval of theophylline should be adjusted accordingly and guided by serum theophylline determinations .

Concomitant administration of multiple doses of ZYFLO (600 mg every 6 hours) and warfarin (fixed daily dose obtained by titration in each subject) to 30 healthy male volunteers resulted in a 15% decrease in R-warfarin clearance and an increase in AUC of 22%. The pharmacokinetics of S-warfarin were not affected. These pharmacokinetic changes were accompanied by a clinically significant increase in prothrombin times. Monitoring of prothrombin time, or other suitable coagulation tests, with the appropriate dose titration of warfarin is recommended in patients receiving concomitant ZYFLO and warfarin therapy .

Co-administration of ZYFLO and propranolol results in a significant increase in propranolol concentrations. Administration of a single 80-mg dose of propranolol in 16 healthy male volunteers who received ZYFLO 600 mg every 6 hours for 5 days resulted in a 42% decrease in propranolol clearance. This resulted in an increase in propranolol C max . AUC, and elimination half-life by 52%, 104%, and 25%, respectively. There was an increase in ?-blockade and decrease in heart rate associated with the co-administration of these drugs. Patients on ZYFLO and propranolol should be closely monitored and the dose of propranolol reduced as necessary. No formal drug-drug interaction studies between ZYFLO and other beta-adrenergic blocking agents (i. e. ?-blockers) have been conducted. It is reasonable to employ appropriate clinical monitoring when these drugs are co-administered with ZYFLO.

In a drug interaction study in 16 healthy volunteers, co-administration of multiple doses of terfenadine (60 mg every 12 hours) and ZYFLO (600 mg every 6 hours) for 7 days resulted in a decrease in clearance of terfenadine by 22% leading to a statistically significant increase in mean AUC and C max of terfenadine of approximately 35%. This increase in terfenadine plasma concentration in the presence of ZYFLO was not associated with a significant prolongation of the QTc interval. Although there was no cardiac effect in this small number of healthy volunteers, given the high inter-individual pharmacokinetic variability of terfenadine, co-administration of ZYFLO and terfenadine is not recommended.

Drug-drug interaction studies conducted in healthy volunteers between ZYFLO and prednisone and ethinyl estradiol (oral contraceptive), drugs known to be metabolized by the P450 3A4 (CYP3A4) isoenzyme, have shown no significant interaction. However, no formal drug-drug interaction studies between ZYFLO and dihydropyridine, calcium channel blockers, cyclosporine, cisapride, and astemizole, also metabolized by CYP3A4, have been conducted. It is reasonable to employ appropriate clinical monitoring when these drugs are co-administered with ZYFLO.

Drug-drug interaction studies in healthy volunteers have been conducted with ZYFLO and digoxin, phenytoin, sulfasalazine, and naproxen. There was no significant interaction between ZYFLO and any of these drugs.

Leutrol Contraindications

E-Mycin Oral Uses, Side Effects, Interactions, Pictures, Warnings - Dosing, Ermycin

E-Mycin

GENERIC NAME(S): ERYTHROMYCIN BASE

Uses

Erythromycin is used to treat a wide variety of bacterial infections. It may also be used to prevent certain bacterial infections. Erythromycin is known as a macrolide antibiotic. It works by stopping the growth of bacteria.

This antibiotic treats or prevents only bacterial infections. It will not work for viral infections (such as common cold. flu ). Unnecessary use or misuse of any antibiotic can lead to its decreased effectiveness.

OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.

This medication may also be used to treat a certain type of stomach condition involving slowed digestion (gastroparesis ).

How to use E-Mycin

Take this medication by mouth as directed by your doctor. This medication is best absorbed when taken on an empty stomach. If nausea occurs, you may take it with food or milk. Swallow the medication whole. Do not crush, chew, or break it.

The dosage and length of treatment are based on your medical condition and response to treatment. In children, the dosage is also based on age and weight .

Antibiotics work best when the amount of medicine in your body is kept at a constant level. Therefore, take this drug at evenly spaced intervals. To help you remember, take it at the same times each day.

If you are using this medication to treat an infection, continue to take this medication until the full prescribed amount is finished, even if symptoms disappear after a few days. Stopping the medication too early may result in a return of the infection. Tell your doctor if your condition persists or worsens.

If you are taking this medication to prevent certain bacterial infections, take it exactly as directed by your doctor. Do not stop taking the medication without your doctor's approval.

Side Effects

Nausea, vomiting. diarrhea. stomach pain /cramping, and loss of appetite may occur. Taking this medication with food may lessen these symptoms. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: signs of liver disease (such as persistent nausea/vomiting, yellowing eyes or skin. dark urine, severe stomach/abdominal pain), unusual tiredness, muscle weakness. slurred speech, blurred vision. drooping eyelids, hearing loss .

Get medical help right away if you have any very serious side effects, including: severe dizziness. fainting. fast/irregular heartbeat .

This medication may rarely cause a severe intestinal condition (Clostridium difficile - associated diarrhea) due to a type of resistant bacteria. This condition may occur during treatment or weeks to months after treatment has stopped. Tell your doctor right away if you develop: persistent diarrhea, abdominal or stomach pain/cramping, blood /mucus in your stool.

Do not use anti-diarrhea products or narcotic pain medications if you have any of these symptoms because these products may make them worse.

Use of this medication for prolonged or repeated periods may result in oral thrush or a new yeast infection. Contact your doctor if you notice white patches in your mouth. a change in vaginal discharge or other new symptoms.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction. including: rash. itching /swelling (especially of the face/tongue /throat), severe dizziness, trouble breathing .

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking erythromycin, tell your doctor or pharmacist if you are allergic to it; or to other macrolide antibiotics (such as azithromycin. clarithromycin ); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease. a certain type of muscle disease (myasthenia gravis ).

Erythromycin may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.

The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using erythromycin, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (heart failure. slow heartbeat, QT prolongation in the EKG ), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).

Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/"water pills") or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using erythromycin safely.

Erythromycin may cause live bacterial vaccines (such as typhoid vaccine) not to work as well. Therefore, do not have any immunizations/vaccinations while using this medication without the consent of your doctor.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Some erythromycin products may contain sodium. Ask your doctor or pharmacist for more information if you are on a salt-restricted diet or if you have a condition such as congestive heart failure that could be worsened by an increase in salt intake.

Older adults may be more sensitive to the side effects of this drug, especially hearing loss and QT prolongation (see above).

Tell your doctor if you are pregnant before using this medication.

This medication passes into breast milk. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: clindamycin, digoxin.

Many drugs besides erythromycin may affect the heart rhythm (QT prolongation), including amiodarone, dofetilide, cisapride, pimozide, procainamide, propafenone, quinidine, sotalol, among others.

Other medications can affect the removal of erythromycin from your body, which may affect how erythromycin works. Examples include azole antifungals (such as itraconazole, ketoconazole), certain calcium channel blockers (such as diltiazem, verapamil), certain anti-seizure medications (such as carbamazepine, phenytoin), quinupristin-dalfopristin, among others.

Erythromycin can slow down the removal of other drugs from your body, which may affect how they work. Examples of affected drugs include bromocriptine, colchicine, certain benzodiazepines (such as midazolam, triazolam), eletriptan, ergot alkaloids (such as ergotamine, dihydroergotamine), certain drugs to treat erectile dysfunction-ED or pulmonary hypertension (such as sildenafil, tadalafil), certain "statin" drugs (such as lovastatin, simvastatin), vinblastine, among others.

Although most antibiotics are unlikely to affect hormonal birth control such as pills, patch, or ring, a few antibiotics (such as rifampin, rifabutin) can decrease their effectiveness. This could result in pregnancy. If you use hormonal birth control, ask your doctor or pharmacist for more details.

This medication may interfere with certain laboratory tests (urine tests), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

Overdose

If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Notes

Do not share this medication with others.

This medication has been prescribed for your current condition only. Do not use it later for another infection unless your doctor directs you to do so. A different medication may be necessary in that case.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Information last revised October 2015. Copyright(c) 2015 First Databank, Inc.

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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Drug Overdose

Buy Heart Disease - Valsabela (Brand Name Diovan) Online - Order Valsartan - Purchase Heart Disease

Common use This medication is a peripheral vasodilatator with a hypotension effect. It specifically blocks angiotensin I receptors. Results of Valsartan activity may be observed in 2 hours after its intake, maximal effect is reached in 4-6 hours. Duration of its actions is over 24 hours. Valsartan is used to treat chronic heart failure (NYHA class III-IV). The medication in particular is prescribed after heart attacks.

Dosage and direction Once a day together with food or before a meal. Maximal daily dose is 160 mg, usual dose is 80 mg daily. Depending on your condition dosage may change. Do not take this medication if it was not administered to you. Follow all directions of your doctor.

Precautions FDA pregnancy category D. Valsartan may be harmful to an unborn baby. Continue treatment with this medication even if you feel fine unless your doctor told you different. In rare cases, Valsartan can cause a condition that results in the breakdown of skeletal muscle tissue, which then leads to kidney failure. In this case such symptoms as fever, nausea, dark colored urine, muscle pain appear and you should inform your doctor immediately about it to avoid further complications.

Contraindications Hypersensitivity, pregnancy, breastfeeding. The medication should be administered cautiously in patients with a biliary cirrhosis, bile duct obstruction, kidney failure, stenosis of kidney artery.

Possible side effect Headache, dizziness, asthenia, insomnia, diarrhea, abdominal pain, vomit, coughing, running nose, impotence, reduced renal function, and allergic reactions.

Drug interaction Potassium-sparing diuretics, K+ medications, salts which contain K+ in interaction with Valsartan may facilitate development of hyperpotassemia. Diuretics in combination with Valsartan cause hypotention.

Missed dose If you missed a dose take it as soon as you remember, but not if it is almost time of the next intake by your schedule. If it occured skip the missed dose. Do not try to compensate a missed dose by taking an extra one.

Overdose If you suppose that you overdosed Valsartan seek for immediate medical attention. Symptoms of overdose may include dizziness, increased heart rate, increased levels of potassium in the blood, kidney failure, Loss of consciousness.

Storage Store Valsartan at room temperature, 15-30 C (59-86 F).

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Paseos - Definition Of Paseos By The Free Dictionary, Pasetocin

paseo

ambulatory - a covered walkway (as in a cloister); "it has an ambulatory and seven chapels"

boardwalk - a walkway made of wooden boards; usually at seaside

catwalk - narrow pathway high in the air (as above a stage or between parts of a building or along a bridge)

flagging - a walk of flagstones; "the flagging in the garden was quite imaginative"

path - a way especially designed for a particular use

mall. promenade - a public area set aside as a pedestrian walk

sidewalk. pavement - walk consisting of a paved area for pedestrians; usually beside a street or roadway

skywalk - an elevated walkway between buildings (usually enclosed)

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