Isotretinoin, Accutane Acne Prescription Side Effects & Dosage, Claravis

isotretinoin (Claravis, Amnesteem, Absorica, Myorisan, Zenatane, Sotret, Accutane)

BRAND NAME: Claravis, Amnesteem, Absorica, Myorisan, Zenatane, Sotret

DISCONTINUED BRAND: Accutane

GENERIC AVAILABLE: Yes

Isotretinoin is used to treat severe acne that is resistant to more conservative treatments such as creams, drying agents, and topical or oral antibiotics. Complete remission or prolonged improvement is seen in many patients after one course of 15 to 20 weeks of isotretinoin. Because of its serious side effects, isotretinoin should be used only for severe resistant acne.

Because isotretinoin causes birth defects. isotretinoin is sold only under a special program approved by the Food and Drug Administration called iPLEDGE. Isotretinoin can only be prescribed by healthcare providers and dispensed by pharmacies registered in iPLEDGE.

The most common side effects of isotretinoin are:

Joint aches also are common. Patients may develop an increase in blood cholesterol and triglycerides. Psychiatric problems such as depression. hallucinations and suicidal behavior have been reported.

Other side effects include:

Serious side effects include:

Erythema multiforme and severe skin reactions (for example, Stevens-Johnson syndrome, toxic epidermal necrolysis) have been associated with isotretinoin use. These events may be serious and result in life-threatening events or death, hospitalization, or disability. Patients should be monitored closely for severe skin reactions, and isotretinoin discontinued if necessary.

Medically Reviewed by a Doctor on 9/8/2016

Quick Guide Adult Acne (Pimples) Causes, Solutions and Treatments

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Rilexine Chewable Tablets For Animal Use, Rilexine

Rilexine Chewable Tablets

This page contains information on Rilexine Chewable Tablets for veterinary use . The information provided typically includes the following:

Rilexine Chewable Tablets Indications

Warnings and cautions for Rilexine Chewable Tablets

Direction and dosage information for Rilexine Chewable Tablets

Rilexine Chewable Tablets

This treatment applies to the following species:

Dogs

(cephalexin) Chewable Tablets for Dogs

Antimicrobial for Oral Use in Dogs only

Rilexine Chewable Tablets Caution

Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.

Description

RILEXINE ® Chewable Tablets are a chewable, bisected tablet supplied in 4 sizes containing 150 mg, 300 mg, and 600 mg of cephalexin. Cephalexin is a cephalosporin, beta-lactam, broad spectrum antibiotic. The full chemical name for cephalexin is 7-(D-α-amino - α-phenylacetamido)-3-methyl-3-cephem-4-carboxylic acid monohydrate.

INDICATION: For the treatment of secondary superficial bacterial pyoderma in dogs caused by susceptible strains of Staphylococcus pseudintermedius .

Dosage and Administration

The recommended dose is 22 mg/kg (10 mg/lb) of body weight twice daily for 28 days.

Appropriate culture and susceptibility tests should be performed before treatment to determine the causative organism and its susceptibility to cephalexin. Therapy with RILEXINE Chewable Tablets may be initiated before results of these tests are known; once the results become available, antimicrobial therapy should be adjusted accordingly. If acceptable response to treatment is not observed, then the diagnosis should be re-evaluated and appropriate alternative therapy considered.

Contraindications

RILEXINE Chewable Tablets are contraindicated in dogs with a known allergy to cephalexin or to the β-lactam (any of the penicillins or cephalosporins) group of antibiotics.

Warnings

For use in dogs only. Not for use in humans. Keep this drug out of the reach of children. Antimicrobials, including penicillins and cephalosporins, can cause allergic reactions in sensitized individuals. Sensitized individuals handling such antimicrobials, including cephalexin, should avoid contact of the product with the skin and mucous membranes in order to minimize the risk of allergic reactions.

In case of ingestion by humans contact a physician immediately. Physicians may contact a Poison Control Center for advice concerning cases of ingestion by humans.

To obtain a copy of the Material Safety Data Sheet (MSDS), or to report adverse reactions, call Virbac at 1-800-338-3659.

Precautions

Prescribing antibacterial drugs in the absence of a proven or strongly suspected bacterial infection is unlikely to provide benefit to treated animals and may increase the risk of the development of drug-resistant animal pathogens.

The safe use of RILEXINE Chewable Tablets in dogs intended for breeding and in pregnant or lactating bitches has not been evaluated.

Positive direct Coombs’ test results and false positive reactions for glucose in the urine have been reported during treatment with some cephalosporin antimicrobials. Cephalosporin antimicrobials may also cause falsely elevated urine protein determinations. Some antimicrobials, including cephalosporins, can cause lowered albumin values due to interference with certain testing methods.

Occasionally, cephalosporins have been associated with myelotoxicity, thereby creating a toxic neutropenia 1. Other hematological reactions observed with cephalosporin therapy include neutropenia, anemia, hypoprothrombinemia, thrombocytopenia, prolonged prothrombin time (PT) and partial thromboplastin time (PTT), platelet dysfunction, and transient increases in serum aminotransferases 2 .

Adverse Reactions

The most common adverse reactions in dogs include diarrhea, vomiting, anorexia and lethargy. To report suspected adverse reactions call Virbac at 1-800-338-3659.

A total of 211 dogs were included in the field study safety analysis. Adverse reactions reported in dogs treated with RILEXINE Chewable Tablets and placebo are summarized in Table 1.

Table 1: Number of Adverse Reactions* Reported During the Field Study with RILEXINE Chewable Tablets

*Some dogs may have experienced more than one adverse reaction or more than one occurrence of the same adverse reaction during the study.

No clinically significant differences were observed in the mean values for all laboratory tests including urinalysis between RILEXINE Chewable Tablets and placebo-treated dogs. At the end of treatment, group means for neutrophils, WBC, and globulin values were significantly higher in the placebo group than in the RILEXINE Chewable Tablets group; whereas, group mean values for eosinophils, A/G Ratio values, and total protein values were significantly higher in the RILEXINE Chewable Tablets group than in the placebo group. For all six of these parameters, the differences were not clinically significant and the mean values for each of the parameters remained within the normal range.

Clinical Pharmacology

Cephalexin belongs to the cephalosporin family of bactericidal antibiotics.

Cephalexin is readily and almost completely absorbed following oral administration (90% absolute bioavailability). Blood concentrations are proportional to dose within the range of at least 15 to 45 mg/kg. Binding to canine plasma proteins is low, ranging from 9 to 13% for cephalexin concentrations of 0.5 to 100 µg/mL.

Food reduces the peak cephalexin concentrations but has negligible effect on the extent of absorption.

A summary of the pharmacokinetics (PK) observed in fed and fasted Beagle dogs administered a single 22 mg/kg dose is provided in Table 2.

Table 2: Pharmacokinetics Parameter values (mean ± standard deviation), protein-corrected in fasted and fed dogs following a single administration of 22 mg/kg dose of RILEXINE Chewable Tablets (N = 12)

1 SD = Standard Deviation

Cephalosporins are associated with time-dependent killing effects. Accordingly, the pharmacodynamic (PD) target is time above MIC (T>MIC). For staphylococcal infections, the goal for time above MIC is 40% of the dosing interval (which translates to 4.8 hrs for a BID dosing schedule). For streptococcal infections, the target for time above MIC is 60% of the dosing interval (i. e. 7.2 hrs). To assess whether or not the PK-PD target is met with a 22 mg/kg BID dosing regimen under fed and fasted conditions, it was assumed that the MIC 90 for S. pseudintermedius is 2 µg/mL, 8 µg/mL for S. aureus . and 0.5 µg/mL for S. canis . Plasma drug concentrations were normalized to exactly 22 mg/kg dose and corrected for 10% protein binding (protein binding observed in canine plasma).

Under fasted conditions, all targets were met in all dogs after the first daily dose. With food, the target for S. aureus was met by the second daily dose. Therefore, a 22 mg/kg BID dosing interval under fed or fasted conditions succeeded in attaining the PK-PD targets.

MICROBIOLOGY: Cephalexin is a cephalosporin antibiotic. Like other β-lactam antimicrobials, cephalexin exerts its inhibitory effect by interfering with bacterial cell wall synthesis. This interference is primarily due to its covalent binding to the penicillin-binding proteins (PBPs) (i. e. transpeptidase and carboxypeptidase), which are essential for synthesis of the bacterial wall. Minimum Inhibitory Concentrations (MICs) for cephalexin against label-claim pathogens isolated from canine pyoderma in a 2008-2009 U. S. field trial are presented in Table 3. All MICs were determined in accordance with the Clinical Laboratory Standards Institute (CLSI) standards.

Table 3: Summary of Cephalexin MIC values against S. pseudintermedius isolates from 88 dogs treated with RILEXINE ® Chewable Tablets for bacterial pyoderma in a U. S. field study during 2008-2009

Microbial Treatment Outcome

Time of Sampling

MIC Range µg/mL

Post-treatment (n = 17)

*No post-treatment sampling was conducted due to the absence of lesions.

**Of the 27 failures, 10 did not have positive post-treatment cultures.

Effectiveness

The clinical effectiveness of RILEXINE Chewable Tablets was established in a randomized, multi-location, placebo-controlled field study (see Table 4). In this study, 131 dogs with secondary superficial bacterial pyoderma treated with either RILEXINE Chewable Tablets (n = 91) at 22 mg/kg (10 mg/lb) body weight or with a negative control (n = 40), twice daily for 28 days, were analyzed. RILEXINE Chewable Tablets were considered superior to the placebo (70% success rate vs. 13% respectively) in the treatment of secondary superficial bacterial pyoderma caused by susceptible strains of Staphylococcus pseudintermedius .

Table 4: Primary endpoint: Percentage of Cure* (Effectiveness population)

*Absence of lesions at the end of the study.

Palatability: The palatability of RILEXINE Chewable Tablets was evaluated in two separate multi-location studies. In the first study, 39 client-owned dogs were dosed with RILEXINE Chewable Tablets at 22 mg/kg and evaluated for palatability of the product. Palatability testing was performed twice daily prior to feeding for 7 days. Dogs freely consumed (from empty bowl or open hand) 80.8% of their doses. In a second study, 64 client-owned dogs enrolled in the field efficacy study were evaluated in a similar manner and freely consumed 78.4% of their doses.

ANIMAL SAFETY: RILEXINE Chewable Tablets were administered orally three times a day to 12-week-old healthy Beagles at 0 mg/kg (placebo), 22 mg/kg (1X), 66 mg/kg (3X), and 110 mg/kg (5X) for 12 weeks, and at 22 mg/kg twice a day for 12 weeks. The most common clinical findings included epiphora, salivation, vomiting and diarrhea among all the dose groups. Three dogs had decreased activity (1 in each from the 22 mg/kg twice a day, 22 mg/kg three times a day, and the 66 mg/kg three times a day groups). These observations were mild and sporadic.

There were increases in alanine aminotransferase (ALT) in the 110 mg/kg three times a day group and in the 22 mg/kg twice a day group that increased in a dose-dependent pattern. There was an increase in sorbitol dehydrogenase (SDH) in the 110 mg/kg three times a day group compared to the controls. These changes were minimal and the values remained within expected historical control ranges. There were several decreases in total protein (in the 110 mg/kg three times a day group) and/or globulin (in the 22, 66, and 110 mg/kg three times a day groups) compared to the controls. These changes resulted in occasional increases in albumin/globulin ratios. Although a drug effect cannot be ruled-out, these changes were not clinically relevant.

A mild prolongation in prothrombin time (PT) was observed in the 22 mg/kg three times a day group. This was not considered clinically relevant due to the small change that remained within the reference ranges.

One dog in the 110 mg/kg three times a day group had moderate amounts of bilirubinuria at the Week 8 and Week 12 samplings. No clinical significance was noted.

Cephalexin was not present in any Day 1 samples prior to dosing or in any control animals. After dosing, cephalexin was well absorbed into systemic circulation of the treated dogs. Within gender and dosage level, Week 8 mean trough concentrations were generally higher than the Week 4 and 12 mean trough concentrations (between a 0.9 and 3.6-fold difference). The geometric mean plasma cephalexin trough concentration following three times daily administration of the 110 mg/kg dose was 11.2 µg/mL compared to 2.6 µg/mL and 8.7 µg/mL following 22 mg/kg and 66 mg/kg, respectively at Week 12. Geometric mean plasma cephalexin trough concentrations following administration of 22 mg/kg twice daily were 0.7, 1.3, and 1.0 µg/mL at Weeks 4, 8, and 12, respectively.

STORAGE INFORMATION: Store at 20°C-25°C (68°F-77°F), with excursions permitted between 15°C-30°C (59°F-86°F).

How Supplied

RILEXINE (cephalexin) Chewable Tablets are supplied in 150 mg, 300 mg, and 600 mg tablets packaged in bottles of 100 tablets.

NADA 141-326, Approved by FDA.

Distributed by: Virbac Animal Health, Inc. Fort Worth, TX 76137 USA

Revision date 08/2011

1 Birchard SJ and Sherding RG. Saunders Manual of Small Animal Practice, 2nd edition. W. B. Saunders Co. 2000: p. 166.

2 Adams HR. Veterinary Pharmacology and Therapeutics . 8 th edition, 2001, p. 825.

RILEXINE is a registered trademark of Virbac S. A.

Buy Lollarm - Flavoxate - Online Without Prescriptions, Lollarm

Urispas (Lollarm)

Urispas (Flavoxate) reduces muscle spasms of the bladder and urinary tract.

Urispas is used to treat bladder symptoms such as frequent or urgent urination, increased night-time urination, bladder pain, and incontinence (urine leakage). These bladder symptoms are often caused by overactive bladder, prostate enlargement, bladder infections, or irritation of the urethra. Urispas will not treat a bacterial or fungal bladder infection. Infections must be treated with an antibiotic.

Urispas may also be used for other purposes not listed in this medication guide.

Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

Check the label on the medicine for exact dosing instructions. An extra patient leaflet is available with Urispas. Talk to your pharmacist if you have questions about this information. Take Urispas by mouth 30 minutes after eating the same meal each day. Swallow Urispas whole. Do not break, crush, chew, or open capsules before swallowing. If you miss a dose of Urispas, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. If you miss more than 2 dose of Urispas. contact your doctor for instructions.

Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended.

Store this product at the room temperature of 77 degrees F (25 degrees C) away from light and moisture. Brief storage between 59-86 degrees (15-30 degrees C) is permitted.

Active Ingredient: Flavoxate

You should not use this medication if you are allergic to Urispas, or if you have untreated or uncontrolled narrow-angle glaucoma, a blockage in your digestive tract (stomach or intestines), or if you are unable to urinate.

Before using Urispas, tell your doctor if you have glaucoma or urinary problems. Urispas can cause drowsiness or blurred vision. Be careful if you drive or do anything that requires you to be alert and able to see clearly. There may be other medicines that can interact with flavoxate. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

Stop using this medication and call your doctor if you have serious side effects such as hot and dry skin, confusion, pounding heartbeats, fluttering in your chest, or if you stop urinating.

Be sure your doctor knows if you have:

a blockage in your stomach or intestines;

a history of stomach ulcer or bleeding; or

if you are unable to urinate.

Before using it, tell your doctor if you are allergic to any drugs, or if you have:

If you have any of these conditions, you may need a dose adjustment or special tests to safely take Urispas. FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether flavoxate passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using flavoxate and call your doctor at once if you have any of these serious side effects:

hot, dry skin and extreme thirst;

pounding heartbeats, fluttering in your chest; or

urinating less than usual or not at all.

Less serious side effects may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

Zithromax (Z-Pak) – Antibiotic Can Have Serious Heart Side Effects, Zepac

Zithromax

Zithromax (Z-Pak) is an antibiotic that treats a number of infections. The drug is linked to an increased risk of fatal heart problems.

Zithromax (azithromycin) is an antibiotic used to treat bacterial infections such as bronchitis, pneumonia, and infections of the ears, lungs and other organs. First approved by the FDA in 1992 to treat certain respiratory and skin infections, its use has since expanded to include a wide variety of bacterial infections, including sexually transmitted diseases, bacterial inflammations, and middle-ear infections in children. It is available in three forms: as a tablet, a liquid and an extended-release liquid.

Zithromax has been highly profitable for its manufacturer, Pfizer. Although the wide availability of generics means that Zithromax no longer brings in the billions per year it once did, U. S. sales still totaled $435 million in 2012.

In March 2013, however, the FDA warned the public about fatal heart-related risks of Zithromax that may open Pfizer up to legal liability.

Zithromax and Z-Pak Dosage

Zithromax is most familiar to the public as the “Z-Pak,” a convenient five-day pill regimen with half the doses of many other popular antibiotics. As an antibiotic, it is not effective in treating viral infections such as a cold or the flu. A doctor determines whether an infection or disease is bacterial by examining the symptoms—respiratory infections, for example, are often bacterial rather than viral.

With the Z-Pak, patients take a double dose on the first day and then a normal dose for four days. In some cases, Zithromax is prescribed in a single, large dose. This “megadose” can be used to treat ear infections in children or sexually transmitted diseases, such as gonorrhea. A three-day treatment option for sinusitis and some other bacterial infections is also available, but is less common than the Z-Pak.

Doctors choose an antibiotic based on its effectiveness against specific strains of bacteria, its strength against bacterial resistance, and its ease of use. For example, patients are more likely to correctly follow the treatment regimen of a more convenient antibiotic such as Zithromax.

How Zithromax Works

Zithromax belongs to a class of antibiotics called macrolides, which are bacteriostatic – meaning they treat infections by preventing bacteria from multiplying and producing the proteins that are essential for their growth. Eventually, the remaining bacteria die or are killed by the immune system, not by the drug itself. This is in contrast to bactericidal antibiotics, which kill bacteria.

Zithromax does not break down in the body as quickly as other antibiotics. Instead of floating feely in the blood, it gets picked up by white blood cells that fight bacteria. The white blood cells take the medicine to the front lines of their struggle with germs, where it becomes concentrated in the tissues surrounding the infection. That concentration helps it remain in the body longer, which means patients need fewer doses to beat their infections.

In clinical trials, Zithromax was effective at fighting bacterial infection, including some antibiotic-resistant strains. Studies conducted before approval of the drug measured its minimum inhibitory concentration (MIC) in relation to a host of bacteria. A MIC is the lowest concentration of an antibiotic that will inhibit the growth of bacteria and thereby kill them. A lower MIC means a more effective antibiotic.

In a 1991 study in the European Journal of Clinical Microbiology and Infectious Diseases, Zithromax was found to have a markedly low MIC compared with three other types of antibiotics, meaning it was highly effective—resolving, for example, 92 percent of gonorrhea infections treated.

Side Effects of Zithromax

In most cases, Z-Paks are well-tolerated in patients. In clinical trials, side effects were found to occur in approximately 12 percent of patients, and less than 10 percent of those side effects were classified as severe. Most side effects were mild and included diarrhea, nausea and abdominal pain. No other side effects that occurred in clinical trials had a frequency greater than 1 percent.

Side effects with a frequency of less than 1 percent include:

Some rare but serious side effects have been reported, however, including fatal heart problems, allergic reactions and liver disease.

Abnormal Heart Activity and Sudden Cardiac Death

In May 2012, a study in the New England Journal of Medicine reported an increase in cardiovascular death in patients treated with azithromycin compared with patients treated with amoxicillin, ciprofloxacin or no drug. The study was prompted by evidence found in FDA adverse events databases that azithromycin promotes irregular heartbeats, which caused the study’s authors to hypothesize that incidences of cardiovascular death may increase for patients on the drug. Researchers concluded that patients at a high risk for cardiovascular death, including those with existing QT interval prolongation, low blood levels of potassium or magnesium, a slower than normal heart rate or patients taking drugs to treat arrhythmias, were more likely to die while taking azithromycin than patients on other antibiotics or none at all.

The risk of death while on azithromycin increased proportionally with the patients’ Cardiovascular Risk Score: The study found 245 excess deaths in patients with the highest risk scores, compared with just 9 excess deaths in patients with the lowest risk scores. Since this increased death rate did not continue once patients finished their 5-day courses of azithromycin, researchers concluded the increased risk must stem from the drug and only last as long as the drug remains in the body.

Following this study, the FDA issued a public statement detailing the study and warning that the Z-Pak may have previously unknown side effects relating to risk of cardiovascular death. In March 2013, based on new studies funded by Pfizer in response to the research in the New England Journal of Medicine, the FDA issued a stronger public warning that azithromycin, including brand names Zithromax, Zmax, Azithrocin and Azin, “can cause abnormal changes in the electrical activity of the heart that may lead to a potentially fatal irregular heart rhythm.”

People with diabetes, a high risk of heart failure, or a previous heart attack are at the most risk of abnormal heart rhythms while taking Zithromax. The authors of the New England Journal study say doctors should consider prescribing a different drug, such as amoxicillin, for such high-risk patients. For the vast majority of patients who have no heart problems, there is no increased risk. The original NEJM study found only 47 additional deaths per 1 million courses of treatment, most of which occurred in patients with serious pre-existing heart conditions.

A recent study sponsored by the Danish Medical Research Council found no evidence of increased risk of death for young and middle-aged adults without heart problems who took Zithromax compared with those who took a different antibiotic such as penicillin. Researchers concluded that “any increased risk of cardiovascular death associated with azithromycin is restricted to high-risk patients” with a history of heart disease or problems.

Hepatotoxicity (Toxic Liver Disease)

Because Zithromax is metabolized and processed in the liver, patients with liver problems or abnormal liver function may be at risk of serious problems from the drug. Hepatotoxicity (toxic liver disease) and hepatitis have been reported in patients taking Zithromax, occasionally resulting in death. Zithromax should be discontinued if there are signs of hepatitis, such as fatigue, muscle aches, loss of appetite, dark urine or abdominal discomfort.

Hypersensitivity

Serious allergic reactions to Zithromax have been reported, including angioedema (rapid swelling), anaphylaxis (allergic shock), and skin reactions. In rare cases, these reactions resulted in death.

If an allergic reaction occurs while on Zithromax, contact a doctor immediately.

Alternatives to Zithromax

People who suffered allergic reactions or side effects from Zithromax may be faced with finding an alternative antibiotic to treat infections. Fluoroquinolones. such as Cipro, Levaquin and Avelox, are the most popular class of antibiotics prescribed in the U. S. They are popular because they treat a wide variety of illnesses, such as urinary tract infections and respiratory issues. While they can be an effective alternative to the Z-Pak, these drugs are also not without their side effects.

Studies show these drugs can damage the walls of the aorta, the largest blood vessel in the body that carries blood from the heart to other organs. Fluoroquinolones may cause aortic dissections (rips) and aortic aneurysms (bulges) in the aorta. These conditions can lead to serious health problems including strokes, heart attacks, kidney failure, paralysis and death. They are also linked to tendon damage. Patients and doctors should weigh the risks and benefits when deciding on picking an alternative antibiotic.

Did you use antibiotics such as Cipro, Levaquin or Avelox, and suffer from aortic dissection or aortic aneurysm?

Zithromax and Antibiotic Overuse

One of the most important issues with Zithromax is one that plagues almost all antibiotics: overprescription. Many patients get prescriptions for antibiotics when they do not need them: More than 133 million courses of antibiotics are prescribed by doctors each year, according to the American College of Physicians, and about half of those are prescribed for viral infections that antibiotics cannot treat. This overuse results in the evolution of antibiotic-resistant “super germs,” as bacteria that survive the antibiotic’s onslaught pass on their strengths during reproduction.

These drug-resistant bacteria can cause very serious illnesses. In 2011, for example, a multidrug-resistant bacterial “superbug” killed 12 people after striking a health care center run by the National Institutes of Health. Such antibiotic-resistant super germs will only get more common if overuse of antibiotics continues.

Patients with the flu, a cold or any other kind of viral infection should not ask doctors to prescribe an antibiotic. Not only will it not help, since antibiotics have no effect on viruses, but taking such medication can reduce future responsiveness to antibiotics. Some bacterial infections do not need antibiotics, either. Doctors decide when an antibiotic is needed.

Zithromax Lawsuits

In March 2013, Pfizer noted that in collaboration with the FDA, it had “updated the Zithromax (azithromycin) label with regards to a specific, rare heart rhythm abnormality in patients with risk factors” for heart disease and that “this potential risk is well established in macrolide antibiotics.” This was the first public information supplied by Pfizer about cardiovascular death associated with Zithromax in the two decades since its introduction.

Because Pfizer did not issue any warnings to the public about the danger of cardiovascular death until nearly 22 years after it started marketing the drug, families of those who have died while taking Zithromax may be able to sue the drugmaker. Drug manufacturers are expected to thoroughly test their products and ensure their safety before releasing them to the market. Any lawsuit filed against Pfizer over Zithromax will likely allege that the drugmaker either knew or should have known about the increased risk of cardiovascular death, and failed in its duty to warn the public.

Last modified: March 4, 2016

Pfizer, Inc. (2013, January 29). Pfizer reports fourth-quarter and full-year 2012 results; provides 2013 financial guidance [Press release]. Retrieved from http://pfizer. newshq. businesswire. com/press-release/pfizer-reports-fourth-quarter-and-full-year-2012-results-provides-2013-financial-guida

Simpson, N. (2010). Azithromycin. Pediatrics for Parents. 26(7-8): 19.

Herper, M. (2002, April 16). Drug giants duel over kids' ear infections. Forbes. Retrieved from http://www. forbes. com/2002/04/16/0416drugkids. html

Pfizer, Inc. (2013, February). Zithromax Physician Labeling. Retrieved from http://labeling. pfizer. com/ShowLabeling. aspx? id=511.

Food and Drug Administration. (2013, March 12). Azithromycin (Zithromax or Zmax): Drug Safety Communication – Risk of Potentially Fatal Heart Rhythms.

Grady, D. (2012, May 16). Popular Antibiotic May Raise Risk of Sudden Death. The New York Times. Retrieved from http://www. nytimes. com/.

Ray, W. A. Murray, K. T. Hall, K. Arbogast, P. and Stein, C. M. (2012, May 17). Azithromycin and the Risk of Cardiovascular Death. New England Journal of Medicine. 366:1881-189. Retrieved from http://www. nejm. org/doi/full/10.1056/NEJMoa1003833 .

Harrison, J. W. (1998, April). "The beginning of the end of the antibiotic era? Part II. Proposed solutions to antibiotic abuse." Quintessence International. 29(4): 223–9.

Williams, J. D. (1991, October). Spectrum Activity of Azithromycin. European Journal of Clinical Microbiology and Infectious Diseases. 10(10):813-820.

Doheny, K. (2013, May 1). Antibiotic Azithromycin Won’t Harm Healthy Hearts: Study. Health Day. Retrieved from http://health. usnews. com/health-news/news/articles/2013/05/01/antibiotic-azithromycin-wont-harm-healthy-hearts-study .

Hopkins, S. (1991, Sept. 12). Clinical Toleration and Safety of Azithromycin. The American Journal of Medicine. 91(suppl 3a): 40s-45s.

Zeltner, B. (2013, June 3). Antibiotics are commonly prescribed, but are they necessary? The Plain Dealer. Retrieved from http://www. cleveland. com/healthfit/index. ssf/2013/06/antibiotics_are_commonly_presc. html .

Drug Alerts

Hytrin - Man S Health, Uro-Hytrin

Hytrin is used for treating high blood pressure and treating signs and symptoms of benign prostatic hyperplasia (BPH). Hytrin is an alpha-blocker. It works by relaxing muscles in the blood vessels, resulting in lowering of blood pressure. In BPH, alpha-blockers work by relaxing muscles around the urethra (tube that drains urine from the bladder), which improves urinary symptoms.

Use Hytrin as directed by your doctor.

Take Hytrin by mouth with or without food.

Hytrin may cause a sudden drop in blood pressure after the first dose. Take your first dose at bedtime. If you get up during the night, sit up slowly, then stand slowly.

If you miss a dose of Hytrin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. If more than one dose is missed, contact your doctor or pharmacist.

Ask your health care provider any questions you may have about how to use Hytrin.

Store Hytrin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Hytrin out of the reach of children and away from pets.

Active Ingredient: Terazosin hydrochloride.

Do NOT use Hytrin if:

you are allergic to any ingredient in Hytrin or to similar medicines (eg, prazosin).

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Hytrin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have prostate cancer, angina pectoris, heart disease, or kidney or liver problems

if you will be having eye surgery.

Some medicines may interact with Hytrin. Tell your health care provider if you are taking any other medicines, especially any of the following:

Phosphodiesterase type 5 (PDE5) inhibitors (eg, sildenafil) or verapamil because severe dizziness, lightheadedness, or fainting may occur.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Hytrin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Hytrin may cause drowsiness, dizziness, blurred vision, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Hytrin with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Hytrin; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.

Hytrin may cause a sudden drop in blood pressure after the first dose. Take your first dose at bedtime. If you get up during the night, sit up slowly, then stand slowly. This will help to reduce your lightheadedness or dizziness. These effects are more likely to occur after the first few doses or if your dose has increased, but can occur at any time while you are taking the medicine. It can also occur if you stop taking the medicine and then restart treatment.

Hytrin may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.

Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.

Do NOT take more than the recommended dose without checking with your doctor.

Hytrin may rarely cause a prolonged, painful erection. This could happen even when you are not having sex. If this is not treated right away, it could lead to permanent sexual problems such as impotence. Contact your doctor right away if this happens.

Tell your doctor or dentist that you take Hytrin before you receive any medical or dental care, emergency care, or surgery (including eye surgery).

Lab tests, including blood pressure, may be performed while you use Hytrin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Hytrin should not be used in children; safety and effectiveness in children have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Hytrin while you are pregnant. It is not known if Hytrin is found in breast milk. If you are or will be breast-feeding while you use Hytrin, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Dizziness; drowsiness; lightheadedness; nasal congestion; nausea; weakness.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision or other vision changes; chest pain; decreased sexual desire or ability; fainting; fast, slow, or irregular heartbeat;painful, prolonged erection; severe or prolonged dizziness or headache; shortness of breath; swelling of the ankles, feet, or hands.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Dermosolon, Dermosolon

Product Description Common use Prednisone is a corticosteroid used to reduce inflammation and alleviate symptoms in a variety of disorders, including rheumatoid arthritis and severe cases of asthma. Prednisone decreases or prevents tissues from responding to inflammation and also modifies the body's response to certain immune stimulation.

Dosage and direction Take it orally with or without food (it's recommended that prednisone be taken with food). Commonly used dosage is various from 5 to 60 mg per day and often is adjusted based on the response of the condition being treated. Corticosteroids should be used for several days for best result. Prolonged therapy with this drug causes the adrenal glands to atrophy and stop producing cortisol, so when Prednisone is discontinued after a period of prolonged therapy, the dose of Prednisone must be tapered to allow the adrenal glands time to recover. Note: this instruction presented here just for review. It's very necessary to consult your doctor before using. It will help you to get the best results.

Precautions You should not start taking Prednisone if you are suffering from a severe bacterial, fungal or viral infection. Do not use this drug without doctor's permission if your medical history includes: kidney disease, a psychiatric condition, heart disease or high blood pressure, liver disease, Diverticulitis, Ulcerative Colitis, or stomach ulcers, hypothyroidism, diabetes mellitus, Myasthenia gravis, osteoporosis or any other medical disorders. Do not stop taking Prednisone suddenly because your own adrenal glands cannot quickly produce enough cortisone. Also note that this drug increases appetite! So you must control your meal. Use caution in children because Prednisone can affect growth. Prednisone should not be used during pregnancy, becoming pregnant or lactating without doctor's advice. Do not use before breast-feeding without doctor's advice.

Contraindications Prednisone is not allowed to people who are hypersensitive to any components of this medicine. Also Prednisone contraindicated in the presence of infections, especially tuberculosis, fungal infectons, amebiasis, vaccinia and varicella, and antibiotic-resistant infections; lactation.

Possible side effect They may include all types of an allergic reaction. Also the most serious side effects include: problems with your vision; swelling, rapid weight gain, feeling short of breath; severe depression, unusual thoughts or behavior, seizure; bloody or tarry stools, coughing up blood; pancreatitis; low potassium; dangerously high blood pressure. Less serious include: sleep problems, mood changes; acne, dry skin, thinning skin, bruising or discoloration; slow wound healing; increased sweating; headache, dizziness, spinning sensation; nausea, stomach pain, bloating; changes in the shape or location of body fat. If you experience one of them stop using Prednisone and tell your doctor as soon as possible. Also consult with your doctor about any side effect that seems unusual.

Drug interaction Prednisine interacts with the following dugs: aspirin; a diuretic; a blood thinner such as warfarin; cyclosporine; insulin or diabetes medications you take by mouth; ketoconazole; rifampin; seizure medications such as phenytoin or phenobarbital. Also note that interaction between two medications does not always mean that you must stop taking one of them. As usual it affects the the effect of drugs, so consult with your doctor about how it interactions are being managed or should be managed.

Missed dose If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not increase your recommended dose. Take your usually dose next day in the same regularly time.

Overdose Symptoms of Prednisone overdose may include thinning skin, easy bruising, changes in the shape or location of body fat, increased acne or facial hair, menstrual problems, impotence, or loss of interest in sex. If you experience one of them or any unusual symptoms call your doctor immediately.

Storage Store at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture, kids and pets. Do not use after expiration term.

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

What is this medicine?

ESCITALOPRAM is used to treat depression and certain types of anxiety.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions: bipolar disorder or a family history of bipolar disorder diabetes heart disease kidney or liver disease receiving electroconvulsive therapy seizures (convulsions) suicidal thoughts, plans, or attempt by you or a family member an unusual or allergic reaction to escitalopram, the related drug citalopram, other medicines, foods, dyes, or preservatives pregnant or trying to become pregnant breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. You can take it with or without food. If it upsets your stomach, take it with food. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine, contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following: certain diet drugs like dexfenfluramine, fenfluramine, phentermine, sibutramine cisapride citalopram medicines called MAO Inhibitors like Nardil, Parnate, Marplan, Eldepryl nefazodone phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine procarbazine St. John's Wort venlafaxine

This medicine may also interact with the following: amphetamine or dextroamphetamine aspirin and aspirin-like drugs carbamazepine cimetidine ketoconazole linezolid medicines for depression, anxiety, or psychotic disturbances medicines that treat or prevent blood clots like warfarin, enoxaparin, and dalteparin medicines that treat HIV infection or AIDS medicines for migraine headache like almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan medicines used to treat tuberculosis like isoniazid, rifabutin, rifampin, rifapentine metoclopramide NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen pentazocine tryptophan

This list may not describe all possible interactions. Give your health care providers a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. Continue taking your tablets even if you do not feel better right away. It can take 1 to 2 weeks or longer before you start to feel the effects of this medicine.

Patients and their families should watch out for worsening depression or thoughts of suicide. Also watch out for sudden or severe changes in feelings such as feeling anxious, agitated, panicky, irritable, hostile, aggressive, impulsive, severely restless, overly excited and hyperactive, or not being able to sleep. If this happens, especially at the beginning of treatment or after a change in dose, call your health care professional.

If you have been taking this medicine regularly for some time, do not stop taking it suddenly. You must gradually reduce the dose, or your symptoms may get worse. Ask your doctor or health care professional for advice.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

Do not treat yourself for coughs, colds, or allergies without asking your doctor or health care professional for advice. Some ingredients can increase possible side effects.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your doctor if the problem does not go away or is severe.

What side effects may I notice from this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible are: allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue confusion feeling faint or lightheaded, falls fast talking and excited feelings or actions that are out of control hallucination, loss of contact with reality seizures suicidal thoughts or other mood changes unusual bleeding or bruising

Side effects that do not require medical attention usually (report to your doctor or health care professional if they continue or are bothersome): blurred vision changes in appetite change in sex drive or performance headache increased sweating nausea

This list may not describe all possible side effects.

Where should I keep my medicine?

Keep out of reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.

Product Description Common use Prednisone is a corticosteroid used to reduce inflammation and alleviate symptoms in a variety of disorders, including rheumatoid arthritis and severe cases of asthma. Prednisone decreases or prevents tissues from responding to inflammation and also modifies the body's response to certain immune stimulation.

Dosage and direction Take it orally with or without food (it's recommended that prednisone be taken with food). Commonly used dosage is various from 5 to 60 mg per day and often is adjusted based on the response of the condition being treated. Corticosteroids should be used for several days for best result. Prolonged therapy with this drug causes the adrenal glands to atrophy and stop producing cortisol, so when Prednisone is discontinued after a period of prolonged therapy, the dose of Prednisone must be tapered to allow the adrenal glands time to recover. Note: this instruction presented here just for review. It's very necessary to consult your doctor before using. It will help you to get the best results.

Precautions You should not start taking Prednisone if you are suffering from a severe bacterial, fungal or viral infection. Do not use this drug without doctor's permission if your medical history includes: kidney disease, a psychiatric condition, heart disease or high blood pressure, liver disease, Diverticulitis, Ulcerative Colitis, or stomach ulcers, hypothyroidism, diabetes mellitus, Myasthenia gravis, osteoporosis or any other medical disorders. Do not stop taking Prednisone suddenly because your own adrenal glands cannot quickly produce enough cortisone. Also note that this drug increases appetite! So you must control your meal. Use caution in children because Prednisone can affect growth. Prednisone should not be used during pregnancy, becoming pregnant or lactating without doctor's advice. Do not use before breast-feeding without doctor's advice.

Contraindications Prednisone is not allowed to people who are hypersensitive to any components of this medicine. Also Prednisone contraindicated in the presence of infections, especially tuberculosis, fungal infectons, amebiasis, vaccinia and varicella, and antibiotic-resistant infections; lactation.

Possible side effect They may include all types of an allergic reaction. Also the most serious side effects include: problems with your vision; swelling, rapid weight gain, feeling short of breath; severe depression, unusual thoughts or behavior, seizure; bloody or tarry stools, coughing up blood; pancreatitis; low potassium; dangerously high blood pressure. Less serious include: sleep problems, mood changes; acne, dry skin, thinning skin, bruising or discoloration; slow wound healing; increased sweating; headache, dizziness, spinning sensation; nausea, stomach pain, bloating; changes in the shape or location of body fat. If you experience one of them stop using Prednisone and tell your doctor as soon as possible. Also consult with your doctor about any side effect that seems unusual.

Drug interaction Prednisine interacts with the following dugs: aspirin; a diuretic; a blood thinner such as warfarin; cyclosporine; insulin or diabetes medications you take by mouth; ketoconazole; rifampin; seizure medications such as phenytoin or phenobarbital. Also note that interaction between two medications does not always mean that you must stop taking one of them. As usual it affects the the effect of drugs, so consult with your doctor about how it interactions are being managed or should be managed.

Missed dose If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not increase your recommended dose. Take your usually dose next day in the same regularly time.

Overdose Symptoms of Prednisone overdose may include thinning skin, easy bruising, changes in the shape or location of body fat, increased acne or facial hair, menstrual problems, impotence, or loss of interest in sex. If you experience one of them or any unusual symptoms call your doctor immediately.

Storage Store at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture, kids and pets. Do not use after expiration term.

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Buy Espontal Online, Order No Prescription Flomax, Espontal

Buy Espontal (Flomax) without Prescription

ESPONTAL (FLOMAX) INDICATIONS

Espontal is used for treating enlarged prostate (benign prostatic hyperplasia [BPH]). Espontal is an alpha-blocker. It works by relaxing muscles in the prostate and bladder, which helps to improve urine flow and reduce symptoms of BPH.

ESPONTAL (FLOMAX) INSTRUCTIONS

Use Espontal as directed by your doctor.

Take Espontal by mouth 30 minutes after eating the same meal each day.

Swallow Espontal whole. Do not break, crush, chew, or open capsules before swallowing.

If you miss a dose of Espontal, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. If you miss more than 2 dose of Espontal, contact your doctor for instructions.

Ask your health care provider any questions you may have about how to use Espontal.

ESPONTAL (FLOMAX) STORAGE

Store Espontal at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Espontal out of the reach of children and away from pets. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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See Also

Pletal - Pain Relief, Ejennu

Pletal (Cilostazol) widens arteries that supply blood to the legs. Cilostazol also improves circulation by keeping platelets in the blood from sticking together and clotting.

Cilostazol is used to treat the symptoms of intermittent claudication. This condition causes reduced blood flow to the legs, leading to pain while walking. Cilostazol improves your ability to walk longer distances without pain.

Cilostazol may also be used for other purposes not listed in this medication guide.

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Take each dose with a full glass of water. Cilostazol is usually taken twice a day, at least 30 minutes before or 2 hours after breakfast or dinner. Take cilostazol at the same times each day. Follow your doctor's instructions.

It may take up to 12 weeks of using cilostazol before your symptoms improve. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not improve after 4 weeks of treatment.

Take cilostazol on an empty stomach, at least 30 minutes before or 2 hours after food.

If you miss a dose of Pletal take it as soon as possible. If several hours have passed or if it is nearing time for the next dose, do not double the dose to catch up, unless advised by your health care provider. Do not take 2 doses at once. If more than one dose is missed, contact your health care provider or pharmacist.

Store cilostazol at room temperature away from moisture, heat, and light.

Active ingredient: cilostazol

Inactive ingredients: carboxymethylcellulose calcium, corn starch, hydroxypropyl methylcellulose 2910, magnesium stearate, and microcrystalline cellulose.

Before taking cilostazol, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: bleeding disorders (such as bleeding ulcers, bleeding in the eye/brain), congestive heart failure, other heart disease (such as heart attack, chest pain, fast/irregular heartbeat), stroke, kidney disease, liver disease, blood disorders (such as hemophilia, low platelet counts).

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Do not take cilostazol if you have congestive heart failure. Cilostazol can make this condition worse.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Cilostazol can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Possible side effects:

Headache, diarrhea, runny nose, and dizziness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these serious side effects occur: fast/pounding/irregular heartbeat, swelling of the hands/feet.

Tell your doctor immediately if any of these unlikely but serious side effects occur: easy bruising/bleeding, black or bloody stools, vomit that looks like coffee grounds, signs of infection (such as fever, persistent sore throat).

Get medical help right away if any of these rare but serious side effects occur: chest/jaw/left arm pain, fainting, vision changes, weakness on one side of the body, slurred speech, confusion.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Kop Cotriatec (Altace) Utan Recept, Cotriatec

Kopa Cotriatec (Altace) Natet Utan Recept

Cotriatec (Altace) Forklaring

Cotriatec ar verkligen en perfekt behandling inom striden mot hogt blodtryck eller ens minskar risken for hjartinfarkt, hjartslag, liksom dod i vissa sjuka.

Cotriatec verkar genom lugnande blodomloppet. Kostsam angiotensinomvandlande kemisk (ACE) hammare.

Cotriatec kan ocksa kallas ramipril, Cardace, Tritace, Ramace, Lopace.

Allmant titeln i samband med Cotriatec ar faktiskt Ramipril piller.

Brand i samband med Cotriatec ar faktiskt Cotriatec.

Cotriatec (Altace) Dose

Cotriatec kommer in:

en 25mg Minuter Dos friktionsmaterial

sekund. 5mg lagre dos friktionsmaterial

5mg Regular Dos friktionsmaterial

10mg Forbattrad Dos friktionsmaterial

Fa Cotriatec genom munnen utan eller med maltider.

Vanligtvis inte slipa eller ens tugga upp detta.

Om du vill astadkomma basta resultaten brukar inte sluta anvanda Cotriatec helt plotsligt.

Cotriatec (Altace) I brist forknippas med doserings

Vanligtvis far inte dubbel dos. Om du hoppar over dosen du behover for att bara den nar du kom ihag nar det galler din saknas. Nar det ar dags for dosering du behover bara pa din egen normal dosering rutin.

Cotriatec (Altace) Overdosering

Om du overdoserar Cotriatec och du undviker ocksa stor att du behover kolla din lakare eller ens lakare omedelbart. Forknippas med Cotriatec overdosering: svimning, allvarlig trotthet eller ens yrsel, viss svaghet.

Cotriatec (Altace) Lagringsutrymme

Shop i rymden temperaturer mellan 10 och 30 nivaer D (59 samt 86 nivaer F) fran fukt och temperatur. Behall text ordentligt stangd. Starka nagon form av orord medicinering efter utgangen dagen. Behall fran uppna barnen.

Cotriatec (Altace) Negativa effekter

Cotriatec ger de negativa effekterna. Den mest typiska tenderar att vara:

hosta friktionsmaterial

trotthet friktionsmaterial

huvudvark friktionsmaterial

trotthet friktion material

Mycket mindre typiska och allvarliga negativa effekter i hela anvander Cotriatec:

allergiska reaktion reaktioner (urtikaria, andas in och andas problem, allergi, samt utbrott ) friktionsmaterial

hjartproblem friktionsmaterial

morkt kissa friktionsmaterial

minskad peeing friktionsmaterial

problem med intag friktionsmaterial

svimning friktionsmaterial

fororening (t. ex. temperatur, frossa, langvarig vark i halsen) friktionsmaterial

onormal hjartrytm friktionsmaterial

kramper friktionsmaterial

magen obehag (med eller till och med utan att ha illamaende eller krakningar eller ens krakningar) friktionsmaterial

associerat med lagre lagt blodtryck (t. ex. svimning, allvarlig trotthet, yrsel) friktionsmaterial

gulfargning fran porerna och huden eller ens ogon friktionsmaterial

Negativa effekter tyder forlitar pa medicin du kanske anvander men dessutom lita pa ditt valbefinnande villkor och en annan aspekter.

Cotriatec (Altace) Kontraindikationer

Vanligtvis far inte Cotriatec om du ar kanslig for att Cotriatec element.

Var forsiktig tillsammans med Cotriatec om du vantar annars du tanker ha ett barn, annars ar du verkligen en medicinsk mamma.

Vanligtvis inte utnyttjar kalium kosttillskott eller ens natrium alternativ.

Cotriatec kanske reducerat formagan av hela kroppen for att kontaminering slaget.

Informera din lakare eller ens tandlakare som du far Cotriatec innan de far nagon form av vard eller till och med tandhygien, ovantade akutvard, eller till och med kirurgisk behandling.

For dem som har hogt blodtryck, brukar inte anvanda receptfria varor som innehaller stimulerande droger. Dessa kan omfatta viktminskning piller eller ens kyliga mediciner.

Diabetic sjuka bor vara forsiktig tillsammans med Cotriatec eftersom det kan paverka din egen blodsocker. Undersok glukosnivaer noga.

Seniorer drabbade bor vara forsiktig tillsammans med Cotriatec. De kan vara mycket mer kansliga for att resultaten.

Om du vill astadkomma basta resultat med nagra negativa effekter ar det lampligt att undvika alkoholhaltiga drycker.

Vanligtvis inte sluta anvanda Cotriatec helt plotsligt.

Cotriatec (Altace) Vanliga fragor

Queen: Mycket basta vasentlig Cotriatec info?

Cotriatec ar verkligen en utmarkt medicin som forbrukas avhjalpa av hypertoni eller ens minskar risken for hjartinfarkt, hjartslag, liksom dod i vissa sjuka. Cotriatec kanske reducerade kapaciteten av hela kroppen for att kontamination strid. Radgor med din lakare innan du bestammer dig for att anvanda sig av en natrium ersatta eller kanske en artikel vars kalium i den. Informera din lakare eller ens tandlakare som du far Cotriatec innan de far nagon form av vard eller till och med tandhygien, ovantade akutvard, eller till och med kirurgisk behandling. For dem som har hogt blodtryck, brukar inte anvanda receptfria varor som innehaller stimulerande droger. Dessa kan omfatta viktminskning piller eller ens kyliga mediciner. Diabetiker drabbade bor vara forsiktig tillsammans med Cotriatec. Det kan paverka din egen blodsocker. Undersok glukosnivaer noga. Utnyttja Cotriatec tillsammans med yttersta forsiktighet i seniorer. De kan vara mycket mer kansliga for att resultaten. Vanligtvis far inte Cotriatec i handelse av allergisk reaktion for denna medicin eller komponenterna. Cotriatec kan inte anvandas om du vantar annars du tanker ha ett barn, annars ar du verkligen en medicinsk mamma. Om du vill uppna basta utfall ar det lampligt att undvika alkohol och inte sluta anvanda Cotriatec helt sudden. A

Queen: Exakt hur ska jag fa Cotriatec?

Fa Cotriatec genom munnen utan eller med maltider. Vanligtvis inte slipa eller ens tugga upp detta. Om du vill uppna basta resultat brukar inte sluta anvanda Cotriatec helt sudden. A

Queen: Exakt vad ska jag fag situationen i samband med overdos?

Vanligtvis inte far Cotriatec piller i stora mangder. I handelse av Cotriatec mer an dos, maste du kolla in lakare eller lakare omedelbart. Forknippas med Cotriatec overdos: svimning, allvarlig trotthet eller yrsel, vissa weakness. A

Queen: Kan man verkligen konsumera alkohol?

Absolut ingen, det ar verkligen oacceptabelt uppskattar alkoholhaltiga beverages. A

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How To Treat Pimples With Fucidin 8 Steps (With Pictures), Fuciderm

How to Treat Pimples with Fucidin

Pimples occur when hair follicles and skin pores become clogged with oil and dead skin, forming a plug. This plug creates an ideal environment for bacteria to grow, producing a large, red, sore pimple. Fucidin is an antibiotic cream that kills bacteria and can help your infected pimples heal faster, but when used incorrectly, it can irritate your skin. While Fucidin may help treat certain types of pimples, it is not specifically approved for the treatment of acne.

Steps Edit

Part One of Two: Applying Fucidin Correctly Edit

Wash the pimple with warm water and a soft wash cloth. This will cleanse and open the pore. [1]

Use mild, non-oily soaps to avoid irritating your skin.

If the pimple is very swollen, applying warm water may cause it to break open and release a small amount of pus. If this occurs, continue washing gently until the pus is gone.

Do not scrub. This will irritate the already inflamed skin.

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Dry your skin with a clean towel. This will make it easier to apply the medication only to the area you want.

This is important because the cream can be an irritant if applied to areas where it is not needed.

Open the tube of Fucidin cream. Remove the cap and use the spike on the cap to break the seal. [2]

If the tube is new, remove the cap and check to be sure that the seal is not broken before opening it yourself. If it is broken, return the tube and get a new one.

Apply the cream to the infected pimple. The medication should be applied three to four times per day, unless directed otherwise by your doctor. [3] Continue the treatment until the pimple heals.

Rub the medication in with a clean finger or a sterile cotton swab.

Use no more than a pea-sized amount and rub it into the skin until you can no longer see it.

Wash your hands afterwards to prevent the medication from irritating the skin on your hands.

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Mason JB. Vitamins, trace minerals, and other micronutrients. In: Goldman L, Schafer AI, eds. Goldman's Cecil Medicine . 24th ed. Philadelphia, PA: Elsevier Saunders; 2011:chap 225.

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Volna-K

My latest treasure, snagged in the early morning hours at the Gaithersburg, Md. hamfest, is a Russian maritime radio known as a Volna-K. Volna means wave in Mother Russia, and the surprising complete manual has a blue and white wave motif on the cover complete with a trawler logo. The set appears to have been designed in the '50's or '60's.

This receiver employs 17 tubes, mostly Russian equivalents of 6BA6, 6BE6, and 6AK5's. Nine bands cover 12 KHz to 23 MHz, less most of the broadcast band. The circuit is double conversion above 1500 KHz with IF's of 915 KHz and 85 KHz. An LC filter at the second IF provides selectivity of 6, 1.5, or 0.5KHz. The fairly large "rainbow" dial is augmented by a sexy projection dial for reasonably precise tuning. There is a crystal calibrator with 100 KHz and 1 MHz positions. Components and build quality are very good. The cabinet and front panel have a very nice hammertone grey finish.

A lot of Teutonic influence is apparent when compared to my WWII Fu. H.E. a intercept receiver: The front panel is taller than wide (15" by 12"). The main dial is large and easy to read. The tuning knob and RF gain are on the lower left for easy left-hand operation while copying code. Band selection is by way of a turret tuner. The set is semi-modular, with cast subassemblies with ample shielding. Resistors are mostly metal film units. In addition, a front panel meter monitors the plate current of the 10 tubes in the signal path for easy fault isolation.

Do any of you know anything about the history and application of this set? It appears to have been tooled for mass production and the serial number is in the 70,000 range. This radio appears to be commercial rather than military. For those of you who saw the receiver at Gaithersburg, I replace the dial window, and made a new dial scale via the scanner and Corel Photo Paint. It looks much better now.

VOLNA-K

The Volna-K is a Russian Navy HF receiver. It was intended as a maritime receiver for the Navy and for commercial shipping. It is a superheterodyne double conversion HF receiver, using 17 miniature valves, and 2 semi-conductor diodes. The valves have Russian numbers, but are equivalent to common American types. It can run off 110 or 220 volts AC, or 28 volts DC. It is intended to receive AM and CW signals down to 0.5 uV levels. The word "volna" translates to "wave". The frequency coverage is 12 kHz to 23 mHz in 9 bands, with gaps around the IF frequencies. There are 3 versions of the Volna-K, each with a slightly different frequency coverage. There is also Volna-P which is the version for submarines.

VOLNA-K VOLNA-K1 VOLNA-K3 Band 1 12 - 60 khz 12 - 60 khz 12 - 60 khz Band 2 100 - 180 khz 100 - 180 khz 60 - 100 khz Band 3 180 - 330 khz 180 - 330 khz 100 - 180 khz Band 4 300 - 600 khz 300 - 600 khz 180 - 330 khz Band 5 1.5 - 2.8 mhz 600 - 1100 khz 330 - 600 khz Band 6 2.8 - 5.0 mhz 1.1 - 1.6 mhz 600 - 1100 khz Band 7 5.0 - 9.0 mhz 5.0 - 9.0 mhz 1.1 - 1.6 mhz Band 8 9.0 - 15.0 mhz 9.0 - 15.0 mhz 1.6 - 2.8 mhz Band 9 15.0 - 23.0 mhz 15.0 - 23.0 mhz 2.8 - 5.0 mhz

Figure 1. Volna-K front view

MANUFACTURE It was made in the Petropavlovsky Radio Factory, in Kirov, USSR. About 70,000 were made from 1959 to 1985 (this one is dated 1969). It was available in grey hammertone or green, with engraved legends. The Volna-K weighs 87 pounds. It is a development of the Melnik receiver from 1949, also made in the same factory. The word "melnik" translates to "flower". The Melnik has the same physical shape (taller than it is wider) with a very similar control layout, the obvious differences being the dial, the aerial input, and the speaker. The controls that are in the same position are, BFO select, IF gain, tuning, bandswitch, AF gain, meter switch, BFO note, and the meter. The Volna-K is also similar in size, function, construction, and weight, to the English B40 Navy receiver.

CONTROLS This radio was not intended for export, so all the controls are labeled in the Russian language, using the CYRILLIC script, so it is difficult to read, but luckily the numbers are the same. There is a speaker in the top left hand corner, which has a cloth baffle on the rear of it. Below the speaker is the BFO switch which is OFF in the left hand position, ON in the middle position, and turns ON the CRYSTAL CALIBRATOR in the right position. The calibrator is controlled by turning the heater on and off, so it takes several seconds to start, and longer to stop. The calibrator can provide markers at 100 khz or 1 mhz positions, selected by setting an internal switch. There are two crystals inside the radio, in cylindrical crystal holders. Turning the valve heater off, increases the life of the valve by avoiding "cathode poisoning". Below this control is the IF BANDWIDTH selection switch, which allows 6 khz, 1.5 khz and 0.5 khz bandwidths. Below this switch is the IF GAIN control, and below this again is the headphones socket. This socket is a 2 pin type which is used on many Russian receivers and transmitters and similar to the type used on 1940s German military equipment.

At the top right hand corner is a meter, which is used to indicate the valve current of each receiver valve. It has a simple scale with a centre green section, to indicate the healthy state of the valves. Below the meter is the BFO PITCH control which allows the operator to tune in CW (morse) or to resolve SSB (single sideband) signals. Below this control is a short stubby shaft projecting through the front panel. It has a large WARNING label next to it, as this is used to adjust the oscillator, and so it affects the receiver calibration. It is intended to be used with the crystal calibrator, to set the frequency for each band. It needs to be pushed in and turned to adjust the frequency, so it cannot be accidentally bumped. Below this is the METER SELECT switch which has 10 positions to allow the valve current to be monitored. The HT rectifier, voltage regulator, current regulator, and the two crystal calibrator valves are not monitored. Below the meter switch is the AF gain control, and below this is another headphone socket.

In the centre of the front panel, is the large semicircular dial (used for coarse frequency setting), and an optical frequency readout above it (for fine frequency setting). The maritime distress frequencies are marked, 500 khz and 2182 khz. It takes 40 turns of the heavy flywheel knob to go from band end to end, which is about 9 feet of tuning scale on the ground glass screen. A label indicates the resolution of each band, 250 hz for band 1, 500 hz for bands 2 and 3, 1 khz for band 4, 2 khz for band 5, 5 khz for bands 6 and 7, and 10 khz for bands 8 and 9. Below the dial is a raised panel, which has the main TUNING knob and the BAND SELECT switch on it. The BAND SELECT switch is pulled out from the lock position, you rotate it to change bands, then you push it back in. A small window shows the band selected. The panel also has the POWER ON switch, the SPEAKER ON switch and the AGC ON switch at the right. In the centre is engraved the name and serial number. The serial number has the date as the first 4 digits. At the bottom is the mains fuse.

DESCRIPTION The Volna-K is a double conversion superheterodyne LF and HF receiver. It is single conversion on bands below 600 kHz. The first IF is 915 kHz and the second IF is 85 kHz, and there are gaps in the frequency coverage to allow for this, 60-100 khz and 600-1500 khz.

The aerial enters the receiver through a low pass filter, and then goes to a gas discharge arrestor. The arrestor would be for protection from static build up, or damage from nearby transmitters. The low pass filter would help reducing RADAR signal interference. The solid alloy turret has 4 tuned circuits per band, 2 cascaded circuits for the aerial tuning, one for the single RF stage (6BA6), and one for the first oscillator (6AS6). Each circuit is enclosed in its own alloy box. There is a 4 gang tuning capacitor in a cast alloy frame, the oscillator capacitor being much larger. The mixer output (6BE6) then goes to the first IF (915 khz), which has 3 valves and 3 tuned circuits (the IF amplifier 6BA6, mixer 6BE6 and oscillator 6AS6) also in individual alloy boxes. This IF amplifier is not used below 600 khz. The next IF (85 khz) also has 2 valves (6BA6), and 3 tuned circuits. The first 2 tuned circuits are the bandpass filters, each one consisting of 3 inductances and several switched capacitors. These are also in individual alloy boxes. It has 3 selectable bandwidths, 6 khz, 1.5 khz, and 0.5 kHz. The AGC amplifier (6AS6) picks off the IF signal here, and uses a diode rectifier (OA91) to generate the AGC. The AGC is applied to both mixers, both IF amplifiers, but not the RF amplifier. The receiver has tremendous gain, and overloads easily when the AGC is turned off. The main IF output is rectified by a diode (OA91) and there is an audio pre-amplifier (6AS6) and a power output amplifier (6AQ5), for the internal speaker or the audio line output. There is negative feedback on the audio stages. The BFO is a single valve (6AS6), which is injected into the last IF. The crystal calibrator oscillator (6AS6), has 2 crystals for different marker frequencies (1 mhz and 100 khz), and a divider (6AS6) for the lower bands. It has a conventional power transformer and double diode rectifier (5U4). The primary can be set for 110, 127, and 220 volts AC. There is a voltage regulator valve for the oscillator HT voltage and a barreter for current regulation of the oscillator heater. The mains power supply unit could be replaced by an optional 24 VDC supply.

Figure 2. Mains Power Supply Unit (barreter, rectifier, regulator)

There is no signal strength meter, but the meter can be switched to show the anode current in each of the 10 active valves. The current changes with signal strength, so this can be used as an indication. The internal crystal calibrator, and a front panel oscillator trim control, allows the dial to be set precisely. Most of the valve cathodes are connected directly to earth, without generating cathode bias. The exceptions are the oscillators, which are electron coupled type, and so the cathode is connected to the oscillator coil. The audio output valve has cathode bias, and so does the audio preamplifier. The only other exception is the RF amplifier which also has cathode bias.

The mechanical construction is of high quality, using several aluminium cast chassis, and the large turret for the band change. The internal chassis are modular and removable, and each tuned circuit has its own cast box. The wiring is with white plastic wire, probably PTFE. All the modules and wiring is easy to get at, with no hidden or inaccessible components. All solder joints have been painted with red varnish. The gear box that drives the tuning capacitor and frequency scales is nice to use and has no backlash.

The manual is in Russian. It has the coil winding data for each coil, and the valve pin numbers and descriptions. There is a comprehensive parts list, circuits, physical wiring diagrams, and mechanical drawings of the tuning dial drive gearing and the optical projection system.

Figure 3. Diode Detector

RESTORATION The radio was very clean when received from St. Petersburg. It required a new mains cord and aerial coax, as they are attached to the case, and loop internally to the chassis. I found that by using the 220 VAC tap on the mains transformer, that the internal voltages were about 10% too high when connected to 240 VAC, so I rewired it for 110 VAC and used an external step down transformer. The radio worked but was noisy and insensitive, and the BFO was unstable. I cleaned and lubricated the IF and AF gain controls and the BFO control, which corrected this. The main tuning knob was loose. I began an alignment and found that the first IF slugs were expoxyed in place, and impossible to move without breaking them. I placed a small capacitor trimmer across them and managed a successful alignment, as all 5 were high in frequency. There was broadcast band breakthrough on the 1.5-2.8 mhz band, but this was removed with the correct alignment. The second IF slugs were sealed with wax so they were easy to reset. There are 15 tuned circuits as they also set the 3 IF bandwidths. When finished, the sensitivity had improved to 22 microvolts into the second mixer grid for 10 dB S/N. The 9 bands were then aligned and gave sensitivities of: Band 1: 10 uV, Band 2: 3 uV, Band 3: 3 uV, Band 4: 1 uV, Band 5: 1 uV, Band 6: 0.5 uV, Band 7: 1 uV, Band 8: 2 uV, and Band 9: 4 uV. It is difficult to use the optical scale when the receiver is out of its case, due to ambient light. There were no components that needed replacing, all resistors, capacitors and valves were fine.

SHORT COMINGS The obvious short coming is its weight, so you would not want to move it very often. The IF gain control is very near the tuning knob, and is easily bumped. The radio could be improved if the control was farther away or if there was more bearing friction within the control. The lack of a signal strength meter can be compensated for by measuring the valve currents, but with the IF gain backed off, there is not always a large movement with a signal. An S meter position would be helpful. It only has 110 VAC and 220 VAC input, a 240 VAC setting would be beneficial to this country. When being removed from the case, be careful as there is mains voltage on the fuse directly in the centre bottom of the front panel. Similarly the meter has exposed terminals with HT on them. None of these are really serious shortcomings.

PERFORMANCE It is a beautiful receiver, very easy to use, and very sensitive. There is so much gain, that when receiving SSB or CW signals, there is an annoying crack at the beginning of every morse letter or SSB syllable, until the AGC reduces the gain. To avoid this, I run the AF gain on full, and use the IF gain control to set the output volume. It is easy to resolve SSB signals, just set the BFO control 15 degrees to the left or right, (depending on the sideband), and use the main tuning knob. It was never intended to resolve SSB signals but it does easily. The receiver is extremely stable, as there is a voltage regulator for the oscillator HT, and a barretter current regulator for the oscillator heater. The other day, I was listening on the 40 meter band to a UK amateur, talking to a Spaniard, a New Zealander, and a Russian. Very nice, a pleasure to use.

REFERENCES Red Ears, Soviet Professional Tube Receivers 1945 - 1970 Years, by V. I. Shapkin, Moscow AVICO - Press 2003, ISBN 5-86309-070-7

Volna-K, an Unusual Russian Maritime Receiver, by Michael O'Beirne, G8MOB, page 8 -17, Radio Bygones No.74, Christmas 2001

Figure 4. Left Hand View (coil covers removed from second IF)

Figure 5. Right Hand View Top: mixer, RF, calibrator Centre: turret Bottom: first IF

Figure 6. Rear View Top left: mixer, RF, calibrator Bottom left: first IF Top right: power supply Bottom right: second IF Centre top: optical scale and tuning capacitor Centre bottom: turret

Figure 7. Speaker

Figure 8. Top View Left: power supply Centre: optical scale, tuning capacitor Right: mixer, RF amplifier, calibrator

Figure 9. Bottom View (turret and cast chassis)

Copyright Ray Robinson VK2ILV

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Дехидратин Нео съдържа активното вещество хидрохлоротиазид, което се отнася към група лекарства, наречени тиазидни диуретици (отводняващи лекарства).

Като въздейства на определени структури в бъбреците Дехидратин Нео повишава количеството на отделена урина и понижава кръвното налягане.

Използва се за лечение на високо кръвно налягане (артериална хипертония); на отоци със сърдечен, чернодробен или бъбречен произход; на безвкусен диабет с бъбречен произход и като помощно средство за лечение на хронична сърдечна недостатъчност (в допълнение към лечението с АСЕ инхибитори). 2. Какво трябва да знаете, преди да приемете Дехидратин Нео?

Не приемайте Дехидратин Нео при:

• Алергия към хидрохлоротиазид, към други сулфонамиди или към някоя от останалите съставки на това лекарство (изброени в точка 6);

• Тежка бъбречна недостатъчност (бъбречна недостатъчност с намаляване или прекратяване на образуването на урина и/или креатининов клирънс < 30 ml/min);

• Тежка чернодробна недостатъчност (чернодробна прекома и кома);

• Нарушения на солевия баланс (ниско съдържание на калий или натрий в кръвта);

• Намален обем на циркулиращата кръв /хиповолемия/

Предупреждения и предпазни мерки:

Говорете с Вашия лекар или фармацевт, преди да приемете Дехидратин Нео, ако

• Имате бъбречни и чернодробни нарушения;

• Имате промени във водно-солевия баланс и киселинния състав на кръвта (хипокалиемия, хипонатриемия, метаболитна ацидоза);

• Имате високи стойности на пикочната киселина и подагра;

• Ако сте диабетик на лечение с инсулин или други противодиабетни средства. Лекарят ще Ви назначи изследвания за проследяване стойностите на кръвната захар.

• Страдате от лупус еритематодес (автоимунно заболяване, наричано още вълчанка).

• Ако имате или сте имали бронхиална астма.

При продължително приложение, тиазидните диуретици могат да предизвикат леко и частично обратимо повишаване на стойностите на общия холестерол, триглицеридите и холестерола с ниска плътност.

Хидрохлоротиазид може да предизвика позитивиране на резултата в анти-допинговия тест. Ако Ви предстои изследване на функцията на паращитовидните жлези лечението с Дехидратин Нео трябва да се преустанови 3-4 дни преди това.

В случай, че се лекувате продължително Вашият лекар ще Ви назначи редовно проследяване на серумните електролити, уреята и креатинина, холестерола и триглицеридите, пикочната киселина и кръвната захар.

Други лекарства и Дехидратин Нео

Информирайте Вашия лекар или фармацевт, ако приемате, наскоро сте приемали или е възможно да приемете други лекарства.

Уведомете лекуващия си лекар, ако приемате:

• Други лекарства за понижаване на кръвното налягане;

• Лекарства от групата на нестероидните противовъзпалителни средства (напр. индометацин, диклофенак, кетопрофен, ибупрофен) и ацетилсалицилова киселина;

• Инсулин и други антидиабетични продукти, приемани през устата;

• Лекарства от групата на бета-блокерите, като метопролол, пропранолол;

• Дигиталисови продукти (напр. дигоксин) за лечение на сърдечна недостатъчност;

• Холестирамин и холестипол;

• Литиеви продукти;

• Кортикостероиди (хормони) и слабителни средства;

• Средства за лечение на подагра;

• Някои лекарствени продукти, използвани в анестезиологията (кураре деривати и ганглио блокиращи агенти);

• Антитуморни продукти (напр. циклофосфамид, метотрексат;

• Антихолинергични продукти (напр. атропин, биперидин);

Дехидратин Нео с храна, напитки и алкохол

Няма данни за необходимост от специален хранителен режим или ограничения на определени видове храни и напитки по време на лечението с този продукт. Алкохолът усилва действието на лекарството.

Бременност, кърмене и фертилитет

Ако сте бременна или кърмите, смятате, че може да сте бременна или планирате бременност, посъветвайте се с Вашия лекар или фармацевт преди употребата на това лекарство.

Необходимо е да информирате Вашия лекар, ако сте бременна или мислите, че може да сте бременна. Обикновено лекарят ще Ви посъветва да вземете друго лекарство на мястото на Дехидратин Нео, тъй като Дехидратин Нео не се препоръчва по време на бременност. Това е защото Дехидратин Нео преминава през плацентата и неговата употреба след третия месец на бременността може да има потенциално увреждащ ефект върху плода и новороденото.

Уведомете Вашия лекар, ако кърмите или Ви предстои да кърмите. Дехидратин Нео не се препоръчва за употреба на майки, които кърмят.

Шофиране и работа с машини

Дехидратин Нео не влияе върху бдителността, но понякога могат да настъпят различни реакции във връзка с понижаване на кръвното налягане, особено в началото на лечението или при включване на друг продукт за лечение на високо кръвно налягане. В резултат на това може временно да се наруши способността за шофиране и работа с машини.

Дехидратин Нео съдържа лактоза монохидрат и пшенично нишесте

Пшеничното нишесте в състава на продукта е подходящо за хора с цьолиакия (глутенова ентеропатия). Пациенти с алергия към пшеница (различна от цьолиакия) не трябва да вземат този продукт.

Ако Вашият лекар Ви е казал, че имате непоносимост към някои захари, посъветвайте се с него, преди да вземете този продукт. 3. Как да приемате Дехидратин Нео?

Винаги приемайте това лекарство точно както Ви е казал Вашият лекар или фармацевт. Дозировка

При високо кръвно налягане - началната доза е 12,5-25 mg (V2-I табл.) веднъж дневно. При необходимост дозата може да се повиши до 50 mg (2 табл.), приети 1 или 2 пъти дневно. Поддържащата доза обикновено е 12,5 mg

При отоци хидрохлоротиазид се прилага по 25-100 mg (1-4 табл.) 1 или 2 пъти дневно. Възможно е ежедневно приемане на продукта или през един ден.

При нефрогенен инсипиден диабет (безвкусен диабет) в началото на лечението денонощната доза е 100 mg (4 табл.), разделена на 2-4 приема, като впоследствие е възможно намаляване на дозата

Като помощно средство за лечение на хронична сърдечна недостатъчност в допълнение към лекарства от групата на АСЕ инхибиторите - no I-IV2 таблетки.

В случай на чернодробни или бъбречни нарушения дозата хидрохлоротиазид трябва съответно да бъде понижена.

При пациенти с тежка сърдечна декомпенсация абсорбцията на хидрохлоротиазид може да бъде нарушена значително.

При деца - обичайната дневна доза е 1 mg/kg до 2 mg/kg, в един или два приема, като тя не бива да надвишава 37,5 mg 1/2 табл.) на ден за деца до 2 години или 100 mg (4 табл.) на ден за деца от 2 до 12 години.

Начин на приложение

Прилага се през устата, като дозировката се определя от лекуващия лекар. Таблетките трябва да се поглъщат цели по време на хранене с достатъчно количество течност.

Продължителността на лечението не е ограничена във времето и зависи от вида и тежестта на заболяването и ефекта от приложената терапия.

Лечението с хидрохлоротиазид, трябва да се преустановява чрез постепенно намаляване на дозата.

Ако сте приели повече от необходимата доза Дехидратин Нео

При прием на по-висока доза от предписаната, веднага се обърнете за помощ към лекар!

При предозиране може да се наблюдава: повишено отделяне на урина, главоболие, слабост, умора, обърканост, повишена нервно-мускулна възбудимост, мускулни болки и крампи, смущения в сърдечния ритъм, промени в електрокардиограмата, спадане на кръвното налягане, гърчове до кома.

Ако сте пропуснали да приемете Дехидратин Нео

Ако сте пропуснали един прием, вземете продукта във времето на следващия регулярен прием да увеличавате дозата.

Ако имате някакви допълнителни въпроси, свързани с употребата на това лекарство, попитайте Вашия лекар или фармацевт. 4. Възможни нежелани реакции

Следните нежеланите лекарствени реакции могат да бъдат наблюдавани:

Чести (засягат до 1 на 10 потребители): нарушение на сърдечния ритъм, тромбоцитопения (намаляване на броя на тромбоцитите, което повишава риска от кървене или образуване на синини); сънливост, изтръпване и мравучкане, парези (частична парализа), загуба на съзнанието до кома; апатия; липса на тонус на гладката мускулатура със запек и образуване на газове; нарушена чревна проходимост до паралитично преплитане на червата; умора; отделяне на магнезий с урината; мускулна слабост; нарушения на водно-електролитния баланс (ниски стойности на калий и натрий, магнезий и хлор, високи стойности на калций); пристъпи на подагра при предразположени пациенти; повишени стойности на глюкоза в кръвта и поява на глюкоза в урината; повишени стойности на липидите в серума (холестерол и триглицериди).

Нечести (засягат до 1 на 100 потребители): слабост, замаяност, сърцебиене, ниски стойности на кръвното налягане и спадане на кръвното налягане при изправяне, което причинява замайване, прималяване или припадък; главоболие; тревожност; загуба на апетит, стомашно-чревни нарушения (напр. гадене, повръщане, диария, болка в областта на корема и спазми); мускулни болки и мускулни схващания (напр. спазми на прасците); повишени стойности на ензима амилаза в кръвта и възпаление на задстомашната жлеза; обратимо повишаване на уреята и креатинина в кръвта, сухота в устата и жажда. При пациенти с изявен диабет може да се влоши обмяната на веществата. Скритият диабет може да стане активен.

Редки (засягат до 1 на 1 000 потребители): тромбози и емболизъм (причинени от сгъстяване на кръвта, особено при пациенти в старческа възраст, които имат съдови заболявания); циркулаторен колапс (рязко спадане на кръвното налягане с възможна временна загуба на съзнание), промени в ЕКГ и повишена чувствителност към гликозиди; намаляване на броя на белите кръвни клетки, което увеличава вероятността от възникване на инфекции, сгъстяване на кръвта, намаляване на броя на червените кръвни клетки, което може да доведе до бледност или пожълтяване на кожата, слабост или задух; гърчове, сънливост, обърканост; леки зрителни нарушения (напр. замъглено виждане, виждане на всичко в жълто, намалена продукция на слъзна течност; късогледството; пневмония; възпаление на бъбречната недостатъчност, остра бъбречна алергични кожни реакции (напр. сърбеж, зачервяване, фоточувствителност, обрив по хода на кръвоносните съдове, уртикария); лекарствена треска, възпаление на съдовете; пожълтяване; еректилна дисфункция (неспособност да се осъществи полов акт).

Много редки (засягат до 1 на 10 000 потребителя): в изолирани случаи силно намаляване на броя на белите кръвни клетки, което увеличава вероятността от възникване на кървене; силно намаляване на броя на кръвните клетки, което води до слабост, поява на синини или увеличена вероятност от възникване на инфекции или имунохемолитична анемия като резултат от образуване на анти-хидрохлоротиазидни антитела при едновременно прилагане на метилдопа; изолирани случаи на внезапна проява на белодробен оток, придружена със симптоми на тежка алергична реакция, която причинява затруднение в дишането или замайване; кожен лупус ернтематозус (автоимунно заболяване, наречено още вълчанка).

5. Как да съхранявате Дехидратин Нео?

При температура под 25°С.

Да се съхранява на място, недостъпно за деца.

Не използвайте това лекарство след срока на годност, отбелязан върху картонената опаковка. Срокът на годност отговаря на последния ден от посочения месец.

Лекарствата не трябва да се изхвърлят в канализацията или в контейнера за домашни отпадъци. Попитайте Вашия фармацевт как да унищожите ненужните Ви лекарства Тези мерки ще спомогнат за опазване на околната среда.

6. Съдържание на опаковката на допълнителна информация

Какво съдържа Дехидратин Нео

Активното вещество в една таблетка е хидрохлоротиазид (hydrochlorothiazide) 25 mg. Помощните вещества са: лактоза, монохидрат; пшенично нишесте; талк; магнезиев стеарат и желатин.

Как изглежда Дехидратин Нео и какво съдържа опаковката?

Бели или почти бели, кръгли плоски таблетки с двустранна фасета, делителна черта от едната страна и диаметър 8 mm.

Таблетката може да бъде разделена на две равни дози.

Дехидратин Нео по 10 таблетки в блистер, по 2 блистера в картонена кутия.

Притежател на разрешението за употреба

ул. "Атанас Дуков" № 29

1407 София, България

"Балканфарма Дупница" АД,

България, гр. Дупница, ул. "Самоковско шосе"3

Тел. (0701) 58 196; Факс. (0701) 58 555

"Балканфарма-Разград" АД бул. "Априлско въстание" № 68, 7200 Разград, България

ВЗАИМОДЕЙСТВИЯ НА ДЕХИДРАТИН НЕО табл. 25 мг. * 20 ACTAVIS

Силно клинично значими взаимодействия ( 18 )

Умерено клинично значими взаимодействия ( 331 )

Маловажно клинично значими взаимодействия ( 37 )

Виж подробно всички ›

ФАЙЛОВЕ ЗА СВАЛЯНЕ КЪМ ДЕХИДРАТИН НЕО табл. 25 мг. * 20 ACTAVIS

ПО НЗОК

Информация за ДЕХИДРАТИН НЕО табл. 25 мг. * 20 ACTAVIS по НЗОК

Paracetamol Uses, Dosage - Side Effects, Panacetamol

Paracetamol

Paracetamol (acetaminophen) is a pain reliever and a fever reducer. The exact mechanism of action of is not known.

Paracetamol is used to treat many conditions such as headache, muscle aches, arthritis, backache, toothaches, colds, and fevers. It relieves pain in mild arthritis but has no effect on the underlying inflammation and swelling of the joint.

Paracetamol may also be used for other purposes not listed in this medication guide.

Important information

There are many brands and forms of paracetamol available and not all brands are listed on this leaflet.

Do not use more of this medication than is recommended. An overdose of paracetamol can cause serious harm. The maximum amount of paracetamol for adults is 1 gram (1000 mg) per dose and 4 grams (4000 mg) per day. Taking more paracetamol could cause damage to your liver. If you drink more than three alcoholic beverages per day, talk to your doctor before taking paracetamol and never use more than 2 grams (2000 mg) per day.

Do not use this medication without first talking to your doctor if you drink more than three alcoholic beverages per day or if you have had alcoholic liver disease (cirrhosis). You may not be able to use paracetamol .

Before using paracetamol. tell your doctor if you have liver disease or a history of alcoholism.

Do not use any other over-the-counter cough, cold, allergy, or pain medication without first asking your doctor or pharmacist. Paracetamol is contained in many combination medicines. If you use certain products together you may accidentally use too much paracetamol. Read the label of any other medicine you are using to see if it contains paracetamol, acetaminophen or APAP. Avoid drinking alcohol while taking this medication. Alcohol may increase your risk of liver damage while taking paracetamol .

Before taking this medicine

Do not use this medication if you are allergic to acetaminophen or paracetamol.

Ask a doctor or pharmacist if it is safe for you to take paracetamol if you have:

a history of alcoholism;

It is not known whether paracetamol will harm an unborn baby. Before using paracetamol. tell your doctor if you are pregnant. This medication can pass into breast milk and may harm a nursing baby. Do not use paracetamol without telling your doctor if you are breast-feeding a baby.

How should I use paracetamol ?

Use paracetamol exactly as directed on the label, or as prescribed by your doctor.

Do not use more of this medication than is recommended. An overdose of paracetamol can cause serious harm. The maximum amount for adults is 1 gram (1000 mg) per dose and 4 grams (4000 mg) per day. Using more paracetamol could cause damage to your liver. If you drink more than three alcoholic beverages per day, talk to your doctor before taking paracetamol and never use more than 2 grams (2000 mg) per day. If you are treating a child, use a pediatric form of paracetamol. Carefully follow the dosing directions on the medicine label. Do not give the medication to a child younger than 2 years old without the advice of a doctor.

Measure the liquid form of paracetamol with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one. You may need to shake the liquid before each use. Follow the directions on the medicine label.

The paracetamol chewable tablet must be chewed thoroughly before you swallow it.

Make sure your hands are dry when handling the paracetamol disintegrating tablet. Place the tablet on your tongue. It will begin to dissolve right away. Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing.

To use the paracetamol effervescent granules, dissolve one packet of the granules in at least 4 ounces of water. Stir this mixture and drink all of it right away. To make sure you get the entire dose, add a little more water to the same glass, swirl gently and drink right away.

Do not take a paracetamol rectal suppository by mouth. It is for use only in your rectum. Wash your hands before and after inserting the suppository.

Try to empty your bowel and bladder just before using the paracetamol suppository. Remove the outer wrapper from the suppository before inserting it. Avoid handling the suppository too long or it will melt in your hands.

For best results from the suppository, lie down and insert the suppository pointed tip first into the rectum. Hold in the suppository for a few minutes. It will melt quickly once inserted and you should feel little or no discomfort while holding it in. Avoid using the bathroom just after inserting the suppository.

Stop using paracetamol and call your doctor if:

you still have a fever after 3 days of use;

you still have pain after 7 days of use (or 5 days if treating a child);

you have a skin rash, ongoing headache, or any redness or swelling; or

if your symptoms get worse, or if you have any new symptoms.

Urine glucose tests may produce false results while you are taking paracetamol. Talk to your doctor if you are diabetic and you notice changes in your glucose levels during treatment.

Store paracetamol at room temperature away from heat and moisture. The rectal suppositories can be stored at room temperature or in the refrigerator.

What happens if I miss a dose?

Since paracetamol is often used only when needed, you may not be on a dosing schedule. If you are using the medication regularly, use the missed dose as soon as you remember. If it is almost time for your next regularly scheduled dose, skip the missed dose and use your next dose as directed. Do not use extra medicine to make up for a missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

The first signs of an paracetamol overdose include loss of appetite, nausea, vomiting, stomach pain, sweating, and confusion or weakness. Later symptoms may include pain in your upper stomach, dark urine, and yellowing of your skin or the whites of your eyes.

What should I avoid?

Do not use any other over-the-counter cough, cold, allergy, or pain medication without first asking your doctor or pharmacist. Paracetamol is contained in many combination medicines. If you use certain products together you may accidentally use too much paracetamol. Read the label of any other medicine you are using to see if it contains paracetamol, acetaminophen or APAP. Avoid drinking alcohol while taking this medication. Alcohol may increase your risk of liver damage while taking paracetamol .

Paracetamol side effects

Get emergency medical help if you have any of these signs of an allergic reaction to paracetamol: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have a serious side effect such as:

low fever with nausea, stomach pain, and loss of appetite;

dark urine, clay-colored stools; or

jaundice (yellowing of the skin or eyes).

This is not a complete list of paracetamol side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Paracetamol dosing information

Usual Adult Paracetamol Dose for Fever:

General Dosing Guidelines: 325 to 650 mg every 4 to 6 hours or 1000 mg every 6 to 8 hours orally or rectally.

Paracetamol 500mg tablets: Two 500 mg tablets orally every 4 to 6 hours

Usual Adult Paracetamol Dose for Pain:

General Dosing Guidelines: 325 to 650 mg every 4 to 6 hours or 1000 mg every 6 to 8 hours orally or rectally.

Paracetamol 500mg tablets: Two 500 mg tablets orally every 4 to 6 hours

Usual Pediatric Dose for Fever:

<=1 month: 10 to 15 mg/kg/dose every 6 to 8 hours as needed.

>1 month to 12 years: 10 to 15 mg/kg/dose every 4 to 6 hours as needed (Maximum: 5 doses in 24 hours)

Fever: 4 months to 9 years: Initial Dose: 30 mg/kg (Reported by one study (n=121) to be more effective in reducing fever than a 15 mg/kg maintenance dose with no difference regarding clinical tolerance.)

>=12 years: 325 to 650 mg every 4 to 6 hours or 1000 mg every 6 to 8 hours.

Usual Pediatric Dose for Pain:

<=1 month: 10 to 15 mg/kg/dose every 6 to 8 hours as needed.

>1 month to 12 years: 10 to 15 mg/kg/dose every 4 to 6 hours as needed (Maximum: 5 doses in 24 hours)

Fever: 4 months to 9 years: Initial Dose: 30 mg/kg (Reported by one study (n=121) to be more effective in reducing fever than a 15 mg/kg maintenance dose with no difference regarding clinical tolerance.)

>=12 years: 325 to 650 mg every 4 to 6 hours or 1000 mg every 6 to 8 hours.

What other drugs will affect paracetamol ?

There may be other drugs that can interact with paracetamol. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

More about Paracetamol (acetaminophen)

Consumer resources

Professional resources

Related treatment guides

Where can I get more information?

Your pharmacist can provide more information about paracetamol .

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2014 Version: 11.01. 12/07/2009

Buy Chloramphenicol Online - Antibiotics Pharmacy Australia, Ramicort

Chloramphenicol

What is Chloramphenicol? Preventing the expansion of bacteria, Chloramphenicol is primarily used for the treatment of infections. However this drug is not suitable for treating common cold, flu, influenza on any sort of virus infection like sore throat or insignificant infections. To treat serious infections this drug is deemed of optimum worth. When all other medicines fail to work, Chloramphenicol works best. However, this drug is seen to be causing some common side Effects such as eye problem or blood problems if such problem persists for more than 3 to 4 days then the doctor should immediately be contacted. However problems like pale skin, unusual bleeding, unusual bruising, weakness, sore throat, fever, tiredness are considered to be all common symptoms which can usually be resisted. But if you find them to be growing worse with every passing moment, the medication should immediately be stopped. How can I use chloramphenicol eye drops?

You need to wash your hands before using the drops.

Then you need to remove the cap from the bottle.

Next you have to tilt your head little and pull the lower lid of your eye, pulling the eyelid downwards will form a pocket.

Holding the bottle overturned close to your eye, release suitable pressure on the bottle and pour one or two drops into the eye.

Apply second drop only when you have missed the first one.

To close your eyes for 1 or 2 mins press gently along the corner thus you can stop the drop from draining away from your eyes.

Do not apply the medicine in one eye rather you should apply it in both of your eyes, one by another.

If you are using single unit then after applying the medications throw it away. If not then replace the cap and keep the Drop for further usage.

How can I use chloramphenicol eye ointment

When you are about to use the eye ointment you need to wash your hands.

Next you have to remove the cap from the tube.

You have to take back your head and pulling the lower lid of your eye downwards you have to form a pocket.

You have to apply the ointment into the pocket.

Using just like a kohl you have to release a thin line ointment alongside the rim of lower lid, you have to apply the eye ointment.

Go over the process in your other eye.

When you are finished with the process, keep in mind that you have to replace the cap on the tube so that the content does not get contaminated.

Can chloramphenicol eye preparations cause any problem?

Chloramphenicol drops and ointment are likely to cause mild irritation. The pain is stinging but it usually passes away. However if you are facing excruciating pain and heavy water discharge from eyes, you should definitely contact the concerned doctor. Often the temporary irritation continues, more than 12 hours, when it happens you should always speak with the pharmacist or the doctor for suitable advice.

Tags Chloramphenicol (Search keywords):

Etodolac, Lodine (Discontinued) Drug Facts, Side Effects And Dosing, Lodine

etodolac, Lodine (Discontinued)

GENERIC NAME: etodolac

DISCONTINUED BRAND: Lodine

DRUG CLASS AND MECHANISM: Etodolac belongs to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs ). Other members of this class include ibuprofen (Motrin. Advil. Nuprin. etc.), naproxen (Aleve. Naprosyn ), indomethacin (Indocin ), nabumetone (Relafen) and numerous others. These drugs are used for the management of mild to moderate pain. fever. and inflammation. They work by reducing the levels of prostaglandins which are chemicals that are responsible for pain and the fever and tenderness that often occur with inflammation. Etodolac blocks the enzyme that makes prostaglandins (cyclooxygenase), resulting in lower concentrations of prostaglandins. As a consequence, inflammation, pain and fever are reduced. The FDA approved etodolac in January 1991.

PRESCRIBED FOR: Etodolac is used for the treatment of inflammation and pain caused by osteoarthritis. rheumatoid arthritis. and juvenile rheumatoid arthritis. It also is used for treating soft tissue injuries, such as tendinitis and bursitis. and menstrual cramps .

Medically Reviewed by a Doctor on 9/10/2015

Quick Guide Rheumatoid Arthritis Symptoms and Treatment

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Finasteride Medlineplus Drug Information, Fisteride

Finasteride

Why is this medication prescribed?

Finasteride (Proscar) is used alone or in combination with another medication (doxazosin [Cardura]) to treat benign prostatic hypertrophy (BPH, enlargement of the prostate gland). Finasteride is used to treat symptoms of BPH such as frequent and difficult urination and may reduce the chance of acute urinary retention (sudden inability to urinate). It also may decrease the chance that prostate surgery will be needed. Finasteride (Propecia) is also used to treat male pattern hair loss (gradual thinning of the hair on the scalp, leading to a receding hairline or balding on the top of the head in men.) Finasteride (Propecia) has not been shown to treat thinning hair at the temples and is not used to treat hair loss in women or children. Finasteride is in a class of medications called 5-alpha reductase inhibitors. Finasteride treats BPH by blocking the body's production of a male hormone that causes the prostate to enlarge. Finasteride treats male pattern hair loss by blocking the body's production of a male hormone in the scalp that stops hair growth.

How should this medicine be used?

Finasteride comes as a tablet to take by mouth. It is usually taken once a day with or without food. Take finasteride at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take finasteride exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

If you are taking finasteride to treat BPH, you should know that finasteride may control your condition, but will not cure it. It may take at least 6 months before your symptoms improve. Continue to take finasteride even if you feel well. Do not stop taking finasteride without talking to your doctor.

If you are taking finasteride to treat male pattern hair loss, it may take at least 3 months before you see any improvement because hair loss and growth happen slowly over time. However, you should expect to see improvement during the first 12 months of your treatment. If you have taken finasteride for 12 months and have not noticed any improvement, further treatment probably will not help. Talk to your doctor about whether you should continue your treatment.

Finasteride will only slow hair loss while you are taking the medication. Continue to take finasteride even if you have already noticed an improvement. Do not stop taking finasteride without talking to your doctor. You will probably lose any hair that grew back while you were taking finasteride during the first 12 months after you stop taking the medication..

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking finasteride,

tell your doctor and pharmacist if you are allergic to finasteride, any other medications, or any of the ingredients in finasteride tablets. Ask your pharmacist or check the patient information for a list of the ingredients.

tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

tell your doctor if you have or have ever had liver disease or prostate cancer.

you should know that finasteride is only for use in men. Women, especially those who are or may become pregnant should not touch broken or crushed finasteride tablets. Touching broken or crushed finasteride tablets may harm the fetus. If a woman who is pregnant or who could become pregnant touches broken or crushed finasteride tablets, she should wash the area with soap and water immediately and call her doctor.

What should I do if I forget a dose?

Skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Finasteride may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

inability to have or maintain an erection

decreased sexual desire

problems with ejaculation (including decreased volume of ejaculate)

pain in the testicles

depression

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

changes in the breasts such as increased size, lumps, pain, or nipple discharge

rash

itching

hives

swelling of the lips and face

difficulty breathing or swallowing

Finasteride may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

Taking finasteride may increase the risk that you will develop high-grade prostate cancer (a type of prostate cancer that spreads and grows more quickly than other types of prostate cancer). Talk to your doctor about the risks of taking finasteride.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www. fda. gov/Safety/MedWatch ) or by phone (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

In case of emergency/overdose

Simvastatin Uses, Dosage - Side Effects, Simavas

Simvastatin

What is simvastatin?

Simvastatin is in a group of drugs called HMG CoA reductase inhibitors, or "statins." It reduces levels of "bad" cholesterol (low-density lipoprotein, or LDL) and triglycerides in the blood, while increasing levels of "good" cholesterol (high-density lipoprotein, or HDL).

Simvastatin is used to lower cholesterol and triglycerides (types of fat) in the blood.

Simvastatin is also used to lower the risk of stroke, heart attack, and other heart complications in people with diabetes, coronary heart disease, or other risk factors.

Simvastatin is used in adults and children who are at least 10 years old.

Important information

In rare cases, simvastatin can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.

Never take simvastatin in larger amounts, or for longer than recommended by your doctor. Follow your doctor's dosing instructions very carefully. Taking too much of this medication may cause serious or life-threatening side effects.

Before taking this medicine, tell your doctor if you have ever had liver or kidney disease, diabetes, or a thyroid disorder, if you are of Chinese descent, or if you drink more than 2 alcoholic beverages daily.

Simvastatin can harm an unborn baby or cause birth defects. Do not use if you are pregnant.

Grapefruit and grapefruit juice may interact with simvastatin and lead to potentially dangerous effects. Do not consume grapefruit products while taking this medication.

Some medicines can cause unwanted or dangerous effects when used with simvastatin. Your doctor may need to change your treatment plan if you use certain antibiotics or antifungal medicines, hepatitis C medication, heart medication, or medicines to treat HIV/AIDS.

Stop taking this medication and tell your doctor right away if you become pregnant.

Before taking this medicine

You should not take this medicine if you are allergic to simvastatin, if you are pregnant or breast-feeding, or if you have active liver disease.

The following drugs can increase your risk of serious muscle problems if you take them together with simvastatin. These drugs should not be used while you are taking this medicine:

an antibiotic--clarithromycin, erythromycin, telithromycin;

antifungal medication--itraconazole, ketoconazole, posaconazole, voriconazole;

hepatitis C medications--boceprevir, telaprevir; or

HIV/AIDS medication--atazanavir, cobicistat (Stribild, Tybost), darunavir, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir, tipranavir.

Before you start taking simvastatin, tell your doctor if you are already using any of these other medicines:

heart medication--amiodarone, amlodipine, diltiazem, dronedarone, ranolazine, verapamil.

To make sure simvastatin is safe for you, tell your doctor if you have:

history of liver disease;

history of kidney disease;

a thyroid disorder; or

if you drink more than 2 alcoholic beverages daily.

Simvastatin can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. This condition may be more likely to occur in older adults and in people who have kidney disease or poorly controlled hypothyroidism (underactive thyroid).

FDA pregnancy category X. This medicine can harm an unborn baby or cause birth defects. Do not take simvastatin if you are pregnant. Stop taking this medication and tell your doctor right away if you become pregnant. Use effective birth control to avoid pregnancy while you are taking this medicine.

Simvastatin may pass into breast milk and could harm a nursing baby. Do not breast-feed while you are taking this medicine.

How should I take simvastatin?

Take simvastatin exactly as prescribed. Follow all directions on your prescription label. Never take this medicine in larger amounts, or for longer than prescribed. Taking too much of this medication may cause serious or life-threatening side effects.

Simvastatin is usually taken at bedtime or with an evening meal. If you take simvastatin more than once daily, take it with meals. Your doctor may occasionally change your dose to make sure you get the best results.

While using simvastatin, you may need frequent blood tests at your doctor's office.

You may need to take simvastatin on a long-term basis for the treatment of high cholesterol. You may need to stop using this medicine for a short time if you have surgery or a medical emergency. Do not stop taking this medicine unless your doctor tells you to.

Simvastatin is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.

Store at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking simvastatin?

Grapefruit and grapefruit juice may interact with simvastatin and lead to unwanted side effects. Avoid the use of grapefruit products while taking this medicine.

Avoid eating foods that are high in fat or cholesterol. Simvastatin will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan.

Avoid drinking alcohol. It can raise triglyceride levels and may increase your risk of liver damage.

Simvastatin side effects

Get emergency medical help if you have any of these signs of an allergic reaction to simvastatin . hives; difficult breathing; swelling of your face, lips, tongue, or throat.

In rare cases, simvastatin can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.

Also call your doctor at once if you have:

signs of a kidney problem--little or no urinating; painful or difficult urination; swelling in your feet or ankles; feeling tired or short of breath; or

liver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common simvastatin side effects may include:

constipation, nausea, stomach pain; or

cold symptoms such as stuffy nose, sneezing, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Simvastatin dosing information

Usual Adult Dose for Prevention of Cardiovascular Disease:

Usual dosage range: 5 to 40 mg orally once a day in the evening

Patients with coronary heart disease (CHD) or at high risk of CHD: Initial dose: 10 to 20 mg orally once a day in the evening started simultaneously with diet and exercise

Patients at high risk for a CHD event due to existing CHD, diabetes, peripheral vascular disease, history of stroke or other cerebrovascular disease: Initial dose: 40 mg orally once a day in the evening

Comments: - Therapy should be individualized according to patient response. - Lipid determinations should be performed after 4 weeks of therapy and periodically thereafter. - Due to the increased risk of myopathy (including rhabdomyolysis), particularly during the first year of treatment, use of the 80 mg dose should be restricted to patients who have been taking 80 mg for 12 months or more without evidence of muscle toxicity.

Usual Adult Dose for Cardiovascular Risk Reduction:

Usual dosage range: 5 to 40 mg orally once a day in the evening

Patients with CHD or at high risk of CHD: Initial dose: 10 to 20 mg orally once a day in the evening started simultaneously with diet and exercise

Patients at high risk for a CHD event due to existing CHD, diabetes, peripheral vascular disease, history of stroke or other cerebrovascular disease: Initial dose: 40 mg orally once a day in the evening

Comments: - Therapy should be individualized according to patient response. - Lipid determinations should be performed after 4 weeks of therapy and periodically thereafter. - Due to the increased risk of myopathy (including rhabdomyolysis), particularly during the first year of treatment, use of the 80 mg dose should be restricted to patients who have been taking 80 mg for 12 months or more without evidence of muscle toxicity.

Usual Adult Dose for Homozygous Familial Hypercholesterolemia:

Recommended dose: 40 mg orally once a day in the evening

Comments: - Simvastatin should be used as an adjunct to other lipid-lowering treatments (e. g. LDL apheresis) or alone if such treatments are unavailable.

Usual Pediatric Dose for Heterozygous Familial Hypercholesterolemia:

Less than 10 years: Not recommended

10 years or older: Initial dose: 10 mg orally once a day in the evening Maintenance dose: 10 to 40 mg orally once a day in the evening Maximum dose: 40 mg orally once a day in the evening

Comments: - Doses should be individualized according to the goal of therapy. - Dose adjustments should be made at intervals of 4 weeks or more. - Prior to treatment initiation patients should be placed on a standard cholesterol lowering diet, which should continue during treatment.

Approved indication: - As an adjunct to diet to reduce total-C, LDL-C, and Apo B levels in adolescent boys and girls who are at least one year postmenarche, 10 to 17 years of age, with HeFH, if after an adequate trial of diet therapy the following findings are present: 1. LDL cholesterol remains 190 mg/dL or greater; or 2. LDL cholesterol remains 160 mg/dL or greater and there is a positive family history of premature cardiovascular disease (CVD) or two or more other CVD risk factors are present in the adolescent patient. The minimum goal of treatment in pediatric and adolescent patients is to achieve a mean LDL-C less than 130 mg/dL. - The optimal age at which to initiate lipid-lowering therapy to decrease the risk of symptomatic adulthood CAD has not been determined.

What other drugs will affect simvastatin?

Many drugs can interact with simvastatin. Not all possible interactions are listed here. Tell your doctor about all your medications and any you start or stop using during treatment, especially:

This list is not complete and many other drugs can interact with simvastatin. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.

Lozasid 50 Mg, Losazid

LOZASID 50 MG/12.5 MG TABLETS

Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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Hyaluronic Acid, Solpent

Other - Solpent (Brand name: hyaluronic acid)

Hyaluronic Acid enhances proteoglycans in the joint matrix, thereby providing support for healthy joint function and maintaining joint shock absorption and cushioning.

As a dietary supplement, take 2 capsules daily, or as directed by a health care practitioner. Take with 8-10 ounces of water, with or without food.

Consult your Health Provider about the dosage appropriate for you.

If you miss a dose of Hyaluronic Acid, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Store Hyaluronic Acid at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Keep Hyaluronic Acid out of the reach of children and away from pets.

Do not take Solpent unless administered by a healthcare professional if:

You are pregnant or breast-feeding.

Hyaluronic Acid is not known to have any side effects if taken as per the prescribed dosage.

Buy Reucid - Allopurinol - Online Without Prescriptions, Reucid

Zyloprim (Reucid)

Zyloprim is used for treating gout. It is used to treat high uric acid levels in the blood or urine caused by certain types of cancer chemotherapy. It is also used to treat certain patients with calcium oxalate kidney stones and high amounts of uric acid in the urine. Zyloprim is a xanthine oxidase inhibitor. It works by lowering the body's production of uric acid.

Use Zyloprim as directed by your doctor.

Take Zyloprim by mouth after meals to decrease stomach upset.

Drinking extra fluids while you are taking Zyloprim is recommended. Check with your doctor for instructions.

Continue to take Zyloprim even if you feel well. Do not miss any dose.

If you miss a dose of Zyloprim, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Zyloprim.

Store Zyloprim at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Zyloprim out of the reach of children and away from pets.

Active Ingredient: Allopurinol.

Do NOT use Zyloprim if:

you are allergic to any ingredient in Zyloprim.

Some medical conditions may interact with Zyloprim. Tell your doctor if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have kidney or liver disease, heart problems (eg, congestive heart failure ), bone marrow problems, high blood pressure, or diabetes.

Some medicines may interact with Zyloprim. Tell your health care provider if you are taking any other medicines, especially any of the following:

Amoxicillin or ampicillin because the risk of developing a skin rash may be increased

Chlorpropamide because the risk of low blood sugar may be increased

Dicumarol or oral anticoagulants (eg, warfarin) because the risk of bleeding may be increased by Zyloprim

Thiazide diuretics (eg, hydrochlorothiazide) or uricosurics (eg, probenecid) because they may increase the risk of Zyloprim's side effects

Cyclosporine or thiopurines (eg, azathioprine, mercaptopurine) because the risk of their side effects may be increased by Zyloprim.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Zyloprim may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Zyloprim may cause drowsiness. This effect may be worse if you take it with alcohol or certain medicines. Use Zyloprim with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

You may experience an increase in gout attacks for several months after you begin taking Zyloprim. Your doctor may give you another medicine (colchicine) to help decrease these gout attacks. Contact your doctor if you experience frequent or severe gout attacks.

It may take 2 to 6 weeks to receive the full benefit of Zyloprim.

Do not take more than the recommended dose or use for longer than prescribed without checking with your doctor.

Zyloprim is not useful for relieving an acute gout attack.

Follow the diet and exercise program given to you by your health care provider.

Lab tests, including uric acid levels and kidney and liver function, may be performed while you use Zyloprim. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Zyloprim while you are pregnant. Zyloprim is found in breast milk. If you are or will be breast-feeding while you use Zyloprim, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blood in urine or painful urination; dark urine; fever, chills, or sore throat; irritation of the eyes; joint pain; loss of appetite; red, swollen, blistered, or peeling skin; stomach pain; unexplained weight loss; unusual bruising or bleeding; unusual muscle pain or weakness; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Customers who bought this product also bought

Zyloprim (Reucid)

Zyloprim is used for treating gout. It is used to treat high uric acid levels in the blood or urine caused by certain types of cancer chemotherapy. It is also used to treat certain patients with calcium oxalate kidney stones and high amounts of uric acid in the urine. Zyloprim is a xanthine oxidase inhibitor. It works by lowering the body's production of uric acid.

Use Zyloprim as directed by your doctor.

Take Zyloprim by mouth after meals to decrease stomach upset.

Drinking extra fluids while you are taking Zyloprim is recommended. Check with your doctor for instructions.

Continue to take Zyloprim even if you feel well. Do not miss any dose.

If you miss a dose of Zyloprim, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Zyloprim.

Store Zyloprim at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Zyloprim out of the reach of children and away from pets.

Active Ingredient: Allopurinol.

Do NOT use Zyloprim if:

you are allergic to any ingredient in Zyloprim.

Some medical conditions may interact with Zyloprim. Tell your doctor if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have kidney or liver disease, heart problems (eg, congestive heart failure ), bone marrow problems, high blood pressure, or diabetes.

Some medicines may interact with Zyloprim. Tell your health care provider if you are taking any other medicines, especially any of the following:

Amoxicillin or ampicillin because the risk of developing a skin rash may be increased

Chlorpropamide because the risk of low blood sugar may be increased

Dicumarol or oral anticoagulants (eg, warfarin) because the risk of bleeding may be increased by Zyloprim

Thiazide diuretics (eg, hydrochlorothiazide) or uricosurics (eg, probenecid) because they may increase the risk of Zyloprim's side effects

Cyclosporine or thiopurines (eg, azathioprine, mercaptopurine) because the risk of their side effects may be increased by Zyloprim.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Zyloprim may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Zyloprim may cause drowsiness. This effect may be worse if you take it with alcohol or certain medicines. Use Zyloprim with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

You may experience an increase in gout attacks for several months after you begin taking Zyloprim. Your doctor may give you another medicine (colchicine) to help decrease these gout attacks. Contact your doctor if you experience frequent or severe gout attacks.

It may take 2 to 6 weeks to receive the full benefit of Zyloprim.

Do not take more than the recommended dose or use for longer than prescribed without checking with your doctor.

Zyloprim is not useful for relieving an acute gout attack.

Follow the diet and exercise program given to you by your health care provider.

Lab tests, including uric acid levels and kidney and liver function, may be performed while you use Zyloprim. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Zyloprim while you are pregnant. Zyloprim is found in breast milk. If you are or will be breast-feeding while you use Zyloprim, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blood in urine or painful urination; dark urine; fever, chills, or sore throat; irritation of the eyes; joint pain; loss of appetite; red, swollen, blistered, or peeling skin; stomach pain; unexplained weight loss; unusual bruising or bleeding; unusual muscle pain or weakness; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Undergraduate Franchise Employees

Degree Programs

Excelsior College offers degrees, certificates, and career development opportunities in a wide range of disciplines.

We offer high-quality academics in a convenient, affordable online format. With degrees and certificates in more than 30 disciplines, Excelsior is the perfect place to get the education you need to move forward in your career—and your life.

School of Business & Technology

Business Degrees

Technology Degrees

Excelsior offers more than 14 business and technology degrees, including business, accounting, nuclear technology, computer technology, and cybersecurity.

School of Liberal Arts

Associate:

Bachelor:

Excelsior offers multiple degrees in liberal arts. Our general liberal arts degree is your shortest, straightest path to a degree.

School of Nursing

Associate:

Bachelor:

A national leader in nursing education, Excelsior is recognized for excellence by the National League for Nursing, a preferred membership organization for nurse faculty and leaders and nurse educators.

School of Health Sciences

Bachelor:

Bachelor's degrees in health sciences equip Excelsior graduates to become leaders in a dynamic industry.

School of Public Services

Bachelor:

Excelsior offers degrees in criminal justice and military studies designed to help leaders prepare for careers in criminal justice, government, not-for-profit management, public administration, and the military.

College Credit Guidelines

As a Taco Bell employee, you may be eligible to receive college credit for your on the job training completed via the Learning Zone Training Programs. See below to determine how many college credits you are eligible to receive.

Taco Bell Training Credit Overview

Excelsior College would like to see you take full advantage of the credits you have earned through the Learning Zone Training Programs. Therefore we have identified both associates and bachelors degree programs that will accept all of the college credits earned through your Learning Zone Training.

Please review the degree charts below to see how your Learning Zone Training credits apply and how many credits would be required for degree completion.

Maximize the number of credits you can transfer by looking at the degree programs below. Ask your Academic Advisor!

Associate in Applied Science/Administrative Management Studies (AAS)

Bachelor of Professional Studies in Business and Management (BPB)

Bachelor of Science in Business, General Business concentration (BSB)

Liberal Arts Degrees

Associate in Science (ASL)

Bachelor of Science (BSL)

View the Transfer Credit details for each level of training:

Team Member Training

Shift Lead Training

Assistant Manager Training

Restaurant General Manager Training

Tuition & Financial Aid

Taco Bell is committed to offering its employees affordable options to degree completion. Excelsior College and Taco Bell have partnered to provide significant discounts on Tuition and Fees for Taco Bell employees, their spouses and domestic partners, in addition to admissible dependent children. As part of the “Graduate College” program, both the Application and Enrollment Fees have been waived to remove any financial obstacles restricting entry into our programs. Tuition per credit has also been reduced 40% .

Please review the “Graduate College” Partner Pricing chart for a detailed breakdown of tuition and fee rates.

Financial Aid:

View Financial Aid Tutorial

To be considered for many of the options listed below you must complete the United States Department of Education's Free Application for Federal Student Aid (FAFSA). With it and along with a study plan and course approval, you can work with your Excelsior College financial aid advisor to determine the best options for you. The process may take up to several weeks. Your advisor will keep you apprised of the status of your financial aid application.

Find financial aid information and tools at our FA Support Center

Review frequently asked questions.

View helpful guides.

Log in (or register if you haven't yet) for more resources:

Chat live with a financial aid officer.

Submit questions or documents.

Track your questions and submitted documents.

Attention Financial Aid Students

The deadline to register for trimester courses for financial aid is as follows:

Fall Trimester: 9/12/2014 Spring Trimester: 1/23/2015 Summer Trimester: 5/22/2015

Exceptions apply for students receiving military tuition assistance.

Please note an admissible dependent child is defined by The Working Families Tax Relief Act of 2004 which states the following: Relationship, the taxpayer's child or stepchild (whether by blood or adoption), foster child, sibling or stepsibling, or a descendant of one of these. Residence, has the same principal residence as the taxpayer for more than half the tax year. Exceptions apply, in certain cases, for children of divorced or separated parents, kidnapped children, temporary Absences, and for children who were born or died during the year. Age, must be under the age of 19 at the end of the tax year, or under the age of 24 if a full-time student for at least five months of the year, or be permanently and totally disabled at any time during the year. Support, did not provide more than one-half of his/her own support for the year ? and having successfully completed a high school diploma or GED) ("Student" or "Students") seek enrollment will apply.

Excelsior's educational partnership with Taco Bell entitles you to significant discounts on tuition and student fees.

In addition, you may be eligible for federal and New York State loans, as well as grants, scholarships, GI Bill tuition assistance, and other forms of financial support. Excelsior's financial aid advisors will work with you to obtain all the forms of support for which you're eligible. We also offer flexible payment plans and budgeting assistance to help keep your education affordable.

Please note that the partnership benefits apply to all associate, bachelor's, and master's degrees.

Course Dates and Deadlines

Apply & Enroll

By following the proceeding steps in the order outlined below, you will establish a MyExcelsior account by creating a Username and Password, identify the degree program that is “Right for You”, submit an Undergraduate Application for Admissions, and ultimately enroll into an Excelsior College degree program.

By successfully completing the 6 steps required for enrollment and matriculation into an Excelsior College degree program, you are embarking upon an intellectual journey which will foster significant growth in both your personal and professional life.

Course Demos

Taking an online course for the first time can be an uneasy experience, specifically for Taco Bell employees who have completed the majority of their college courses within traditional classroom settings. It is our goal at Excelsior College to create a learning environment which promotes academic success through online instruction. Therefore, to better prepare you for the academic journey ahead, we suggest that you view the Excelsior College Course Demonstration videos.

Step 1: Create a “MyExcelsior” Account

A MyExcelsior account gives you access to customized resources and services that help guide you to your educational goals. By creating a MyExcelsior account through the link below, you are notifying Excelsior that you are a Taco Bell employee, spouse/domestic partner, or dependent child of a Taco Bell employee.

Only through this process will you be eligible to receive a waiver of the Undergraduate Application Fee ($80) and the Enrollment Fee ($1065).

To create your very own MyExcelsior account, click the “Create an Account Now” link below:

Step 2: Apply

Found the perfect Undergraduate Degree program? The next step is to apply! You can do this by clicking the "Apply or Enroll" button at the top of any program page, or by clicking the button below.

Excelsior admissions counselors will go through a thorough evaluation of your application, Learning Zone Training transcript, and college/university transcripts. Within 2-3 weeks, Excelsior College will contact you via email and the message center within your MyExcelsior account regarding the status of your application. Continue to check your MyExcelsior account for up to date information!

Admissions procedures may vary slightly, depending on the degree program, the student's status, and other factors. Please visit the Admission Requirements page (if you have not done so already) for more detailed information on the specific admissions steps you should follow.

Excelsior admissions counselors are ready to provide any help you may need during the admissions process. Contact us toll-free at 888-647-2388, ext. 22, or email admissions@excelsior. edu

Step 3: Request Transcripts

Learning Zone Training Program Transcript Submission:

Taco Bell employees will receive a notification within their MyExcelsior account requesting the submission of your Learning Zone ID. Please reply to the notification by providing your Learning Zone ID within 24hrs of receiving this message.

College and University Transcripts

Upon successful completion of the Online Undergraduate Degree Application, Taco Bell employees are encouraged to immediately contact all previously attended academic institutions to have official transcripts, examination score reports, and/or military documentation you listed on your application sent to the Registration and Records Office.

Some or all of the following types of documentation may be required for your application:

Official transcripts from prior colleges you've attended

Military documentation

Foreign credentials

Official documentation of approved business and industry training

For further information about documentation, see the Transcripts and Documentation page. Please send all Official documents to the following address:

Excelsior College Office of Registration and Records 7 Columbia Circle Albany, NY 12203-5159

Note: The issuance date of the transcript must be 3 weeks or less.

Official transcripts must include:

The institution's official seal

The institution's registrar's signature (signature is usually a stamp)

Two forms of student identification on the transcript (e. g. Social Security number and current address, or current address and date of birth)

Do not send unofficial copies. We cannot use unofficial transcripts or documents in our evaluation.

Please provide us with the name by which you are identified on your official transcripts.

Step 4: Enrollment

Once you have received official notification that you have been admitted into the undergraduate degree/certificate program of choice, you can enroll by clicking the "Apply or Enroll" button at the top of any program page, or by clicking the button below.

If you would like assistance with the enrollment process, contact an admissions counselor toll-free at 888-647-2388 ext. 22, or email admissions@excelsior. edu

Step 5: Contact Your Academic Advisor (Course Registration)

We strongly encourage you to connect with your Academic Advisor soon after your enrollment status has been confirmed. Excelsior College advisors will be your guide throughout your academic career at Excelsior College. As an expert in your desired program, your advisor will provide tailored guidance on how to reach your academic milestones by forecasting what courses you should be taking and creating your course roadmap to success! A team of academic advisors will work with you to:

Understand the steps required to complete your degree program.

Evaluate your transcripts.

Select the right courses, exams and other approved sources of credit for fulfilling your degree requirements.

Address your academic concerns.

Now that you are an Excelsior College student, you can begin the course registration process. Start by selecting “Already an Excelsior College Student” on the “Graduate College” home page.

Laser - Definition Of Laser By The Free Dictionary, Laser

laser

laser

laser

(an instrument that produces) a narrow and very intense beam of light. The men were cutting the sheets of metal with a laser; ( also adjective ) a laser beam. laser ??????? ???? лазер laser laser; laserovy der Laser, Laser-. laser; laser - ?????? laser laser ???? laser laser ????? ???? laser lezer laser leysir, leysigeisli laser ???? ??? lazeris lazers; lazera - laser laser laser laser ???? laser laser лазер laser; laserovy laser laser laser ?????????? lazer ?? лазер, оптичний квантовий генератор ???? ???? ?? ???? ????? ??? ??? ????? ?? ??? ?????? ?? ???? ??? la-de ??

?laser printer noun

laserdrukker ??????? ???? лазерен принтер impressora a laser laserova tiskarna der Laserdrucker laserprinter ????????? ?????? impresora a laser laserprinter ????? ????? lasertulostin imprimante a laser ????????? ??????? ???? ??????? laserski printer lezernyomtato printer laser stampante laser ????????? ??? ??? lazerinis spausdintuvas lazerprinteris pencetak laser laserprinter laserskriver drukarka laserowa ????? ???????? лазерный принтер laserova tlaciaren laserski tiskalnik laserski stampac laserskrivare ??????????????????? lazer yaz?c? ????? лазерний принтер ???? ?? ?????? ?? ???? ????? ?? ???? may in la de ?????

laser

la·ser

1. sigla del ingles “Light Amplification by Stimulated Emission of Radiation” (amplificacion de la luz por estimulacion de emision de radiacion);

2. bisturi microquirurgico usado en la cauterizacion de tumores.

This report analyzes the worldwide markets for Laser Systems in US$ Million.

The site represents a major step in laser technology's movement from theory to practical use on the battlefield, said Mike McVey, president of Northrop's directed energy systems business area, in a conference call Tuesday.

Beam quality is important in laser operations for a variety of reasons but, most fundamentally, from the standpoint of how well--or whether--work can be done with the device.

To meet these requirements, a new line of digital imaging smart laser line sensors has been developed.

This is where you, the dental assistant, can be the leader in laser safety for your office.

7), (8)) of the chopper wheel is the ratio of the power in the attenuated beam to the total laser power, or the duty cycle of the chopper.

Second, the laser can be used in near-contact mode, in which the tip of the fiber remains several millimeters apart from the tissue.

They had also found that, by a never-before-seen interaction between light and matter, those pulses were damaging the very laser setups that produced them.

In another instance, a laser cleaning system is used to roughen the surface of bonding points on a PC part where adhesion strength is critical.

Last October, Texans got an eyeful of amazing laser art when the Houston skyline blazed with lasers shooting in all directions from city rooftops.

They also may be used as an alternative to firearms because of favorable laws that do not define possession of a laser as a deadly weapon.

Which is why Woodhams was a bit surprised in mid - 1996, soon after he built his laser. when the FDA told him the custom device exemption didn't apply to him and that, as a regulated device manufacturer, he was violating the law by making and using an unapproved device.

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Antibiotics

Flagyl ER (Anerozol)

Flagyl ER is used for treating certain bacterial infections of the vagina (bacterial vaginosis). Flagyl ER is an oral antiprotozoal and antibacterial. It is thought to work by entering the bacterial cell, acting on some components of the cell, and destroying the bacteria.

Use Flagyl ER as directed by your doctor.

Take Flagyl ER by mouth on an empty stomach at least 1 hour before or 2 hours after eating.

Swallow Flagyl ER whole. Do not break, crush, or chew before swallowing.

To clear up your infection completely, take Flagyl ER for the full course of treatment. Keep taking it even if you feel better in a few days.

If you miss a dose of Flagyl ER, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Flagyl ER.

Store Flagyl ER at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Flagyl ER out of the reach of children and away from pets.

Active Ingredient: Metronidazole.

Do NOT use Flagyl ER if:

you are allergic to any ingredient in Flagyl ER or to another nitroimidazole (eg, tinidazole)

you are in the first trimestr of pregnancy

you are taking busulfan, an ergot alkaloid (eg, ergotamine), or you have taken disulfiram within the past 2 weeks

you are taking an HIV protease inhibitor that contains alcohol (eg, amprenavir solution); check with your pharmacist if you are unsure if the medicine contains alcohol

you drink alcohol.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Flagyl ER. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have nerve, brain, or blood problems; Crohn disease; or a history of liver problems or seizures.

Some medicines may interact with Flagyl ER. Tell your health care provider if you are taking any other medicines, especially any of the following:

Disulfiram because side effects, such as mental or mood changes, may occur

Amiodarone because the risk of irregular heartbeat may be increased

Barbiturates (eg, phenobarbital) or phenytoin because they may decrease Flagyl ER's effectiveness

Anticoagulants (eg, warfarin), busulfan, cyclosporine, ergot alkaloids (eg, ergotamine), HIV protease inhibitors containing alcohol (eg, amprenavir solution ), lithium, or macrolide immunosuppressants (eg, tacrolimus) because the risk of their side effects may be increased by Flagyl ER.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Flagyl ER may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Flagyl ER may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Flagyl ER with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

Do not drink alcohol while you are taking Flagyl ER and for at least 3 days after the last dose.

Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.

Flagyl ER only works against bacteria; it does not treat viral infections (eg, the common cold).

Be sure to use Flagyl ER for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.

Long-term or repeated use of Flagyl ER may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.

Flagyl ER may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Flagyl ER.

Lab tests, including liver function and white blood cell counts, may be performed while you use Flagyl ER. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Flagyl ER with caution in the elderly; they may be more sensitive to its effects.

Flagyl ER should be used with extreme caution in children; safety and effectiveness in children have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Flagyl ER while you are pregnant. Do not use Flagyl ER in the first 3 months of pregnancy. Flagyl ER is found in breast milk. Do not breastfeed while taking Flagyl ER.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Appetite loss; constipation; diarrhea; dizziness; headache; metallic taste; nausea; stomach upset; vomiting.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools; decreased coordination; increased or decreased urination; numbness, tingling, or burning of the arms, hands, legs, or feet; red, swollen, blistered, or peeling skin; seizures; severe diarrhea; severe or persistent dizziness or headache; sore throat, chills, or fever; speech problems; stiff neck; stomach pain or cramps; vaginal itching, odor, or discharge; vision loss or other vision changes; white patches in the mouth.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Your order will be packed safely and secure and dispatched within 24 hours. This is how your parcel will look like, the images are photographs of real shipments. It has the size of a normal protected envelope and it does not disclose its contents.

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Ciclinil (Biaxin) Description

Ciclinil is used to treat many different types of bacterial infections affecting the skin and respiratory system. Ciclinil is also used together with other medicines to treat stomach ulcers caused by Helicobacter pylori.

Ciclinil fights bacteria in the body.

Ciclinil is also known as Clarithromycin, Maclar, Klaricid, Klacid, Clarimac, Claribid.

Generic Name of Ciclinil is Clarithromycin.

Brand Names of Ciclinil are Ciclinil, Ciclinil XL, Ciclinil XL-Pak.

Ciclinil (Biaxin) Dosage

Ciclinil is available in:

250mg Low Dosage

500mg Standard Dosage

Ciclinil is available in tablets and oral suspension.

Take Ciclinil orally.

Take Ciclinil with full glass of water.

Take Ciclinil with or without food.

Do not crush, chew, or break the Ciclinil tablet. Swallow the pill whole.

Shake the Ciclinil oral suspension well before measuring a dose. Measure the Ciclinil oral suspension with a marked measuring spoon or medicine cup.

Take Ciclinil for for 7 to 14 days.

The dosage and the kind of medication depend on the disease and its prescribed treatment.

Do not stop taking Ciclinil suddenly.

Ciclinil (Biaxin) Missing of dose

Do not take double dose. If you miss a dose you should take it as soon as you remember about your missing. If it is the time for the next dose you should continue your regular dosing schedule.

Ciclinil (Biaxin) Overdose

If you overdose Ciclinil and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Ciclinil overdosage: nausea, vomiting, diarrhea, abdominal discomfort.

Ciclinil (Biaxin) Storage

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Keep container tightly closed. Protect from light. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Ciclinil (Biaxin) Side effects

Ciclinil has its side effects. The most common are:

mild stomach pain

nausea

vomiting

diarrhea

upset stomach

unusual or unpleasant taste in your mouth

tooth discoloration

dizziness

headache

anxiety

confusion

skin rash

vaginal itching or discharge

Less common but more serious side effects during taking Ciclinil:

allergy reactions (urticaria, breathing difficulties, rash, and eruption)

uneven heartbeats;

chest pain

shortness of breath

watery or bloody stool

stomach pain

low fever

loss of appetite

jaundice

fever

sore throat

headache with a severe blistering

red skin rash

problems with hearing

Side effects manifestations are not only depend on medicine you are taking but also depend on your health state and on the other factors

Ciclinil (Biaxin) Contra-indications

Do not use Ciclinil if you are allergic to Ciclinil components or to clarithromycin or to similar medicines such as azithromycin (Zithromax), dirithromycin (Dynabac), erythromycin (E. E.S. E-Mycin, Ery-Tab, Erythrocin), troleandomycin (Tao).

Be very careful if you're pregnant or you plan to have a baby, or you are a nursing mother.

Do not use Ciclinil if you take astemizole (Hismanal), cisapride (Propulsid), ergot medicine such as ergotamine (Ergomar, Ergostat, Cafergot, Ercaf, Wigraine), or dihydroergotamine (D. H.E. 45, Migranal Nasal Spray), pimozide (Orap), terfenadine (Seldane).

Try to be careful with Ciclinil usage in case of having liver disease, kidney disease, myasthenia gravis, porphyria; personal or family history of "Long QT syndrome".

Try to be careful with Ciclinil usage in case you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement.

It can be dangerous to stop Ciclinil taking suddenly.

Ciclinil (Biaxin) Frequently asked questions

Q: What is Ciclinil?

A: Ciclinil is a medication of macrolide antibiotics group. Ciclinil fights bacteria in the body.

Q: What for does Ciclinil used?

A: Ciclinil is used to treat many different types of bacterial infections affecting the skin and respiratory system. Ciclinil is also used together with other medicines to treat stomach ulcers caused by Helicobacter pylori.

Q: What is the generic name of Ciclinil?

A: Generic Name is Clarithromycin.

Q: Are there any brand names except Ciclinil?

A: Brand Names are Ciclinil, Ciclinil XL, Ciclinil XL-Pak.

Q: In what forms is Ciclinil available?

A: Ciclinil is available in tablets and oral suspension.

Q: What should I do in case of missing the dose?

A: In case of dose missing you should take your tablet as soon as possible. Do not take double dosage. And if it is right time for the next dosage you should continue your regular schedule of Ciclinil taking.

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Active Substance: rivastigmine Common Name: rivastigmine ATC Code: N06DA03 Marketing Authorisation Holder: Novartis Europharm Limited Active Substance: rivastigmine Status: Authorised Authorisation Date: 1998-12-04 Therapeutic Area: Dementia Parkinson Disease Alzheimer Disease Pharmacotherapeutic Group: Psychoanaleptics

Therapeutic Indication

Symptomatic treatment of mild to moderately severe Alzheimer's dementia.

Symptomatic treatment of mild to moderately severe dementia in patients with idiopathic Parkinson's disease.

What is Prometax?

Prometax is a medicine containing the active substance rivastigmine. It is available as capsules (1.5, 3, 4.5 and 6 mg), as an oral solution (2 mg/ml), and as transdermal patches, which release either 4.6, 9.5 or 13.3 mg rivastigmine across the skin over 24 hours.

What is Prometax used for?

Prometax is used for the treatment of patients with mild to moderately severe Alzheimer’s dementia, a progressive brain disorder that gradually affects memory, intellectual ability and behaviour.

The capsules and oral solution can also be used to treat mild to moderately severe dementia in patients with Parkinson’s disease.

The medicine can only be obtained with a prescription.

How is Prometax used?

Treatment with Prometax should be initiated and supervised by a doctor who has experience in the diagnosis and treatment of Alzheimer’s disease or dementia in patients with Parkinson’s disease. Treatment should only be started if a caregiver is available who will regularly give and monitor the use of Prometax by the patient. Treatment should continue as long as the medicine has a benefit, but the dose can be reduced or treatment interrupted if the patient has side effects.

Prometax capsules or oral solution should be given twice a day, with morning and evening meals. The capsules should be swallowed whole. The starting dose is 1.5 mg twice a day. In patients who tolerate this dose, it can be increased in 1.5-mg steps no more frequently than every two weeks, to a regular dose of 3 to 6 mg twice a day. The highest tolerated dose should be used to get the maximum benefit, but the dose should not exceed 6 mg twice a day.

If the transdermal patches are used, the 4.6-mg-per-24-hours patch should be used first, with the dose increased to the 9.5-mg/24-h patch after at least four weeks if the lower dose is well tolerated. The 9.5-mg/24-h patch should be used for as long as the patient benefits from it. After six months of treatment with 9.5 mg/24 hours, the doctor may increase the dose to 13.3 mg/24 hours if the patient’s condition has worsened. The patches are applied to clean, dry, hairless, intact skin on the back, upper arm or chest, and are replaced every 24 hours. They should not be placed on irritated or red skin, on the thigh or abdomen (tummy), or in places where they will be rubbed by tight clothing. The patches can be worn during bathing and hot weather. The patches should not be cut into pieces. Patients can be switched from the capsules or oral solution to the patches. See the summary of product characteristics (also part of the EPAR) for detailed information.

How does Prometax work?

The active substance in Prometax, rivastigmine, is an antidementia medicine. In patients with Alzheimer’s dementia or dementia due to Parkinson’s disease, certain nerve cells die in the brain, resulting in low levels of the neurotransmitter acetylcholine (a substance that allows nerve cells to communicate with each other). Rivastigmine works by blocking the enzymes that break down acetylcholine: acetylcholinesterase and butyrylcholinesterase. By blocking these enzymes, Prometax allows levels of acetylcholine to be increased in the brain, helping to reduce the symptoms of Alzheimer’s dementia and dementia associated with Parkinson’s disease.

How has Prometax been studied?

Prometax has been studied in mild to moderately severe Alzheimer’s disease. The capsules have been studied in 2,126 patients in three main studies, and the transdermal patches in one main study involving 1,195 patients. Prometax capsules have also been studied in 541 patients with dementia due to Parkinson’s disease. All of the studies lasted six months and compared the effects of Prometax with those of placebo (a dummy treatment). The main measures of effectiveness were the change in symptoms in two main areas: cognitive (the ability to think, learn and remember) and global (a combination of several areas including general function, cognitive symptoms, behaviour and the ability to carry out everyday activities).

An additional study in 27 patients was used to show that Prometax capsules and oral solution produced similar levels of the active substance in the blood.

What benefit has Prometax shown during the studies?

Prometax was more effective than placebo at controlling symptoms. In the three studies of Prometax capsules in patients with Alzheimer’s dementia, patients taking doses of Prometax between 6 and 9 mg per day had an average increase in cognitive symptoms of 0.2 points from a baseline of 22.9 points at the start of the study, where a lower score indicates better performance. This was compared with an increase of 2.6 points from 22.5 in the patients taking placebo. For the global score, patients taking Prometax capsules had in increase in symptoms of 4.1 points, compared with 4.4 in those taking placebo. The Prometax transdermal patches were also more effective than placebo in preventing dementia from getting worse.

The patients with dementia due to Parkinson’s disease taking Prometax capsules showed an improvement in cognitive symptoms of 2.1 points, compared with a worsening of 0.7 points in those taking placebo, from a baseline of around 24 points. The global symptom score also improved more in the patients taking Prometax.

What is the risk associated with Prometax?

The types of side effects seen with Prometax depend on the type of dementia it is being used to treat and whether the capsules, oral solution or transdermal patches are used. Overall, the most common side effects (seen in more than 1 patient in 10) include nausea (feeling sick) and vomiting, particularly during the phase when the dose of Prometax is being increased. For the transdermal patch application site reactions are the most commonly seen side effects. For the full list of all side effects reported with Prometax, see the package leaflet.

Prometax must not be used in people who are hypersensitive (allergic) to rivastigmine, other carbamate derivatives or any of the other ingredients. Prometax must also not be used in patients who are suspected to have had in the past a severe allergic reaction called ‘allergic contact dermatitis’ to Prometax patch.

Why has Prometax been approved?

The CHMP concluded that Prometax has a modest effectiveness in treating the symptoms of Alzheimer’s dementia, although this does reflect an important benefit in some patients. The Committee initially concluded that for the treatment of dementia due to Parkinson’s disease, Prometax’s benefits did not outweigh its risks. However, following a re-examination of this opinion, the Committee concluded that the medicine’s modest effectiveness could also be of benefit to some of these patients. Therefore, the Committee decided that Prometax’s benefits are greater than its risks and recommended that it be given marketing authorisation.

What measures are being taken to ensure the safe use of Prometax?

The company that makes Prometax must ensure that all doctors who intend to prescribe the Prometax 13.3-mg/24-h transdermal patch receive an information pack containing instructions to be given to patients and caregivers on how to use the patch safely as well as a reminder card for patients and caregivers that contains key information on how to use the patch and allows them to record the application and removal of patches.

Other information about Prometax

The European Commission granted a marketing authorisation valid throughout the European Union for Prometax on 4 December 1998.

For more information about treatment with Prometax, read the package leaflet (also part of the EPAR) or contact your doctor or pharmacist.

Source: European Medicines Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

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Designwin, Quoting Software, Outsource Management, Product Costing, Polydene

Products: DesignWin ®

OEM Software:

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This complex product costing process determines what it will cost to build a product including material, labor and overhead costs (MLO). Also supported is the process of adding margins and rolling up a final price for the product.

Commodity Management

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Strategic Sourcing

A robust request for quote (RFQ) web interface with suppliers enables the continuous flow of information on pricing, availability and other market trends. With a constant pulse on your supply chain, through this centralized costing database and a Supplier Relationship Module (SRM), you can quickly determine the best source for a product with the complete knowledge of all the factors that can affect a sourcing decision.

Outsource Management (OSM)

This process tracks costs from suppliers who provide outsource manufacturing services. OEMs can methodically estimate the “should be” costs prior to receiving the supplier’s proposals. Quotes from various manufacturing suppliers can be quickly evaluated to determine the absolute best cost. Information on your direct demand and influence with component level suppliers is easily highlighted

Labor Cost Estimation

Simplifies the calculation of complex labor and equipment costs to determine the total transformation cost of an assembly.

Business Intelligence

A suite of reports transforms data into concise summaries enabling you to spot trends and make the most knowledgeable and profitable business decisions.

"DesignWin saves significant time by eliminating all of the manual work associated with the quoting process. We source over 500,000 ABC components and 400 assemblies. The software allows us to consolidate global demand, giving us leverage over our cost negotiations."

SVP, Operations Storage Systems Manufacturer

Mefac Tablets 500 Mg Milligram, Mefac

MEFAC

IRISH MEDICINES BOARD ACTS 1995 AND 2006

MEDICINAL PRODUCTS(CONTROL OF PLACING ON THE MARKET)REGULATIONS,2007

(S. I. No.540 of 2007)

Case No: 2070139

The Irish Medicines Board in exercise of the powers conferred on it by the above mentioned Regulations hereby grants to

Rowa Pharmaceuticals Limited

an authorisation, subject to the provisions of the said Regulations, in respect of the product

MEFAC 500 mg Film-coated Tablets

The particulars of which are set out in Part I and Part II of the attached Schedule. The authorisation is also subject to the general conditions as

may be specified in the said Regulations as listed on the reverse of this document.

This authorisation, unless previously revoked, shall continue in force from 28/01/2010 .

Signed on behalf of the Irish Medicines Board this

Irish Medicines Board

Date Printed 01/02/2010 CRN 2070139 page number: 1

Summary of Product Characteristics

1 NAME OF THE MEDICINAL PRODUCT

MEFAC 500 mg Film-coated Tablets.

2 QUALITATIVE AND QUANTITATIVE COMPOSITION

Each tablet contains Mefenamic Acid 500 mg.

Also contains Sunset Yellow (E110), approximately 0.0625 per tablet.

For a full list of excipients, see section 6.1.

3 PHARMACEUTICAL FORM

Film coated tablets.

Yellow elliptoid film-coated tablets, about 18 mm in length, marked ‘MEF 500’ on one face and plain on the reverse.

4 CLINICAL PARTICULARS

4.1 Therapeutic Indications

For relief of mild to moderate pain associated with rheumatic muscular or arthritic disorders (including rheumatoid

arthritis), trauma, headache, dental pain, post-operative or post-partum states.

In the management of the pain of dysmenorrhoea.

4.2 Posology and method of administration

Undesirable effects may be minimised by using the lowest effective dose for the shortest duration necessary to control

symptoms (see section 4.4)

Route of Administration

Recommended Dosage Schedule

The usual total daily dose is 1500mg in divided doses.

NSAIDs should be used with particular caution in elderly patients who are more prone to adverse events. The lowest

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Date Printed 01/02/2010 CRN 2070139 page number: 2

Treatment should be reviewed at regular intervals and discontinued if no benefit is seen.

Do not exceed the stated dose.

Mefac should be taken preferably with or after food.

1. Use in patients with intestinal ulceration or inflammation and in patients with inflammatory bowel disease.

2. Use in patients who have a history of gastrointestinal bleeding or perforation, related to previous NSAIDs therapy.

3. Use in patients with an active, or history of recurrent peptic ulcer/haemorrhage (two or more distinct episodes of

proven ulceration or bleeding).

4. Use in patients with renal or hepatic impairment.

5. Use in patients with severe heart failure

6. Use in pregnancy or lactation (see section 4.6)

7. Use in patients previously shown to be hypersensitive (e. g. asthma, bronchospasm, rhinitis, angioedema, urticaria) to

Mefenamic Acid, any of the other ingredients of Mefac tablets, aspirin, ibuprofen or other non-steroidal anti -

8. Use with concomitant NSAIDs including cyclooxygenase 2 specific inhibitors (see section 4.5)

4.4 Special warnings and precautions for use

Undesirable effects may be reduced by using the minimum effective dose for the shortest possible duration necessary to

control symptoms (see section 4.2 and GI and cardiovascular risks below).

Patients treated with NSAIDs long-term should undergo regular surveillance with particular attention to liver

dysfunction, rash, blood dyscrasias or development of diarrhoea. Appearance of any of these symptoms should be

regarded as an indication to discontinue therapy immediately.

Precaution should be taken in patients suffering from dehydration and renal disease, particularly the elderly.

Prolonged use of NSAIDs in the elderly is not recommended. Where prolonged therapy is required, patients should be

Prolonged use of any type of painkiller for headaches can make them worse. If this situation is experienced or

suspected, medical advice should be obtained and treatment should be discontinued. The diagnosis of ‘Medication

Overuse Headache’ should be suspected in patients who have frequent or daily headaches despite (or because of ) the

regular use of headache medications.

Skin reactions: Serious skin reactions, some of them fatal, including exfoliative dermatitis, Stevens-Johnson syndrome,

and toxic epidermal necrolysis, have been reported very rarely in association with the use of NSAIDs (see section 4.8).

Patients appear to be higher risk of these reactions early in the course of therapy, the onset of the reaction occurring in

the majority of cases within the first month of treatment. Mefac 500mg tablets should be discontinued at the first

appearance of skin rash, mucosal lesion, or any other sign of hypersensitivity.

SLE and mixed connective tissue disorder . In patients with systemic lupus erythematosus (SLE) and mixed connective

tissue disorders there may be an increased risk of aseptic meningitis (see section 4.8).

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Date Printed 01/02/2010 CRN 2070139 page number: 3

bronchial asthma since NSAIDs have been reported to precipitate bronchospasm in such patients.

Cardiovascular and cerebrovascular effects: Appropriate monitoring and advice are required for patients with a history

of hypertension and/or mild to moderate congestive heart failure as fluid retention and oedema have been reported in

association with NSAID therapy.

Clinical trial and epidemiological data suggest that use of some NSAIDs (particularly at high doses and in long term

treatment) may be associated with a small increased risk of arterial thrombotic events (for example myocardial

infarction or stroke). There are insufficient data to exclude such a risk for mefenamic acid.

Patients with uncontrolled hypertension, congestive heart failure, established ischaemic heart disease, peripheral

arterial disease, and/or cerebrovascular disease should only be treated with mefenamic acid after careful consideration.

Similar consideration should be made before initiating longer-term treatment of patients with risk factors for

cardiovascular events (e. g. hypertension, hyperlipidaemia diabetes mellitus, smoking).

Caution is required in patients with a history of hypertension and/or heart failure as fluid retention and oedema have

bee reported in association with NSAID therapy.

Elderly: The elderly have an increased frequency of adverse reactions to NSAIDs especially gastrointestinal bleeding

and perforation which may be fatal (see section 4.2).

Gastrointestinal bleeding, ulceration and perforation: GI bleeding, ulceration or perforation which can be fatal, has been

reported for all NSAIDs at any time during treatment, with or without warning symptoms or a previous history of

serious GI events. Smoking and alcohol use are added risk factors.

The risk of GI bleeding, ulceration or perforation is higher with increasing NSAID doses, in patients with a history of

ulcer, particularly is complicated with Haemorrhage or perforation (see section 4.3), in the elderly, these patients

should commence treatment on the lowest dose available. Combination therapy with protective agents (e. g. misoprostol

or proton pump inhibitors) should be considered for these patients, and also for patients requiring concomitant low dose

aspirin, or other drugs likely to increase gastrointestinal risk (see below and section 4.5).

Patients with a history of GI toxicity, particularly when elderly, should report any unusual abdominal symptoms

especially GI bleeding) particularly in the initial stages.

Caution should be advised in patients, receiving concomitant medications which could increase the risk of ulceration or

bleeding, such as oral corticosteroids, anticoagulants such as warfarin, selective serotonin-reuptake inhibitors or anti —

platelet agents such as aspirin (see section 4.5).

When GI bleeding or ulceration occurs in patients receiving Mefac tablets, the treatment should be withdrawn.

As NSAIDs can interfere with platelet function, they should be used with caution in patients with intracranial

haemorrhage and bleeding diathesis

Female fertility: The use of mefenamic acid may impair female fertility and is not recommended in women attempting

to conceive. In women who have difficulties conceiving or who are undergoing investigation of infertility, withdrawal

of mefenamic acid should be considered.

In dysmenorrhoea and menorrhagia, lack of response should alert the physician to investigate other causes.

Epilepsy: Caution should be exercised when treating patients suffering with epilepsy.

The tablet coating contains the colouring agents quinoline yellow and sunset yellow which may cause allergic

Irish Medicines Board

Date Printed 01/02/2010 CRN 2070139 page number: 4

Concurrent therapy with other plasma binding drugs may necessitate a modification in dosage.

Anti-coagulants . NSAIDs may enhance the effects of anti-coagulants, such as warfarin (see section 4.4). Concurrent

administration of mefenamic acid with oral anticoagulant drugs requires careful prothrombin time monitoring.

It is considered unsafe to take NSAIDs in combination with warfarin or heparin unless under direct medical

Lithium . a reduction in renal lithium clearance and elevation of plasma lithium levels. Patients should be observed

carefully for signs of lithium toxicity.

The following interactions have been reported with NSAIDs but have not necessary been associated with Mefac:

Other analgesics . concomitant use of two or more NSAIDs (including aspirin) should be avoided (see section 4.3)

Antidepressants . selective serotonin reuptake inhibitors (SSRIs): increased risk of gastro-intestinal bleeding (see

Anti-hypertensives and diuretics . reduced anti-hypertensive effect and diuretic effect has been observed. Diuretics can

increase the risk of nephrotoxicity.

ACE inhibitors and angiotensin II-receptor antagonists . a reduction in antihypertensive effect and an increased risk of

renal impairment especially in elderly patients. Patients should be adequately hydrated and the renal function assessed

in the beginning and during concomitant therapy.

Diuretics, ACE inhibitors and Angiotensin II Antagonists . NSAIDs may reduce the effect of diuretics and other

antihypertensive drugs. In some patients with compromised renal function (e. g. dehydrated patients or elderly patients

with compromised renal function) the co-administration of an ACE inhibitor or Angiotensin II antagonist and agents

that inhibit cyclo-oxygenase may result in further deterioration of renal function, including possible acute renal failure,

which is usually reversible. These interactions should be considered in patients taking Mefac concomitantly with ACE

inhibitors or angiotensin II antagonists. Therefore, the combination should be administered with caution, especially in

the elderly. Patients should be adequately hydrated and consideration should be given to monitoring of renal function

after initiation of concomitant therapy, and periodically thereafter.

Aminoglycosides . reduction in renal function in susceptible individuals, decreased elimination of aminoglycoside and

increased plasma concentrations.

Anti-Platelet agents . increased risk of gastrointestinal bleeding (see section 4.4)

Cardiac glycosides . NSAIDs may exacerbate cardiac failure and increases in plasma cardiac glycoside levels may

occur when renal function is affected.

Cyclosporin . increased risk of nephrotoxicity of ciclosporin with NSAIDs.

Corticosteroids . increased risk of gastrointestinal ulceration or bleeding (see section 4.4).

Probenecid . reduction in metabolism and elimination of NSAID and metabolites.

Oral hypoglycemic agents . inhibition of metabolism of sulfonylurea drugs, prolonged half-life and increased risk of

Mifepristone . NSAIDs should not be taken for 8-12 days after mifepristone administration, NSAIDs can reduce the

effects of mifepristone.

Irish Medicines Board

Date Printed 01/02/2010 CRN 2070139 page number: 5

Quinolone antibiotics . animal data indicates that NSAIDs can increase the risk of convulsions associated with

quinolone antibiotics. Patients taking NSAIDs and quinolones may have increased risk of developing convulsion.

Tacrolimus . possible increased risk of nephrotoxicity when NSAIDs are given with tacrolimus.

4.6 Pregnancy and lactation

Safety in pregnancy has not been established and because of the effects of drugs in this class on the foetal

cardiovascular system, the use of mefenamic acid in pregnant women is not recommended (see section 4.3)

Trace amounts of mefenamic acid may be present in breast milk and transmitted to the nursing infant. Therefore,

mefenamic acid should not be taken by nursing mothers (see section 4.3)

4.7 Effects on ability to drive and use machines

Undesirable effects such as dizziness, drowsiness, fatigue and visual disturbances are possible after taking NSAIDs. If

affected, patients should not drive or operate machinery.

4.8 Undesirable effects

a) General Description

The most frequently reported side effects associated with mefenamic acid involve the gastrointestinal tract. Diarrhoea

appears to be the most common side effect and is usually dose-related. It generally subsides on dosage reduction, and

rapidly disappears on termination of therapy. Some patients may not be able to continue therapy.

b) Table of adverse reactions

Frequency of reactions: Very common ( ?1/10); common (?1/100 to <1/10); uncommon (?1/1000 to ?1/100); rare (?

1/10,000 to ?1/1000); very rare (?1/10,000), not known (cannot be estimated from the available data).

Blood and the lymphatic system disorders

Frequency not known: autoimmune haemolytic anaemia (see section c), anaemia, hypoplasia bone marrow, haematocrit

decreased, thrombocytopenic purpura, temporary lowering of he white blood cell count (leukopenia) with a risk of

infection, sepsis and disseminated intravascular coagulation

Rare: agranulocytosis, aplastic anaemia, eosinophilia, neutropenia, pancytopenia

Immune system disorders

Frequency not known: anaphylaxis

Metabolism and nutritional disorders

Frequency not known: glucose intolerance in diabetic patients, hyponatraemia

Frequency not known: nervousness

Nervousness system disorders

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Date Printed 01/02/2010 CRN 2070139 page number: 6

Frequency not known: eye irritation, reversible, reversible loss of colour vision

Ear and labyrinth disorders

Frequency not known: ear pain

Frequency not known: palpitations

Frequency not known: hypotension

Respiratory, thoracic and mediastinal disorders

Frequency not known: asthma, dyspnoea

Frequency not known: abdominal pain, diarrhoea (see section c) and nausea with or without vomiting.

Less frequent: anorexia, colitis, constipation, dyspepsia, enterocolitis, flatulence, gastric ulceration with or without

haemorrhage, pancreatitis, steatorrhea

Frequency not known: borderline elevations of one or more liver function tests, cholestatic jaundice

Less frequent: mild hepatotoxicity, hepatitis, hepatorenal syndrome

Skin and subcutaneous tissue disorders

Frequency not known: angioedema, laryngeal oedema, erythema multiforme, face oedema, Lyell’s syndrome (toxic

epidermal necrolysis), perspiration, rash, Stevens-Johnson syndrome, photosensitivity reaction and urticaria.

Renal and urinary disorders

Frequency not known: allergic glomerulonephritis, acute interstitial nephritis, dysuria, haematuria, nephritic syndrome,

non-oliguric renal failure (particularly in dehydration), proteinuria, renal failure including renal papillary necrosis

Very rare: multi-organ failure, pyrexia

c) Information characterising individual serious and/or frequently occurring adverse reactions

Reversible haemolytic anaemia: Reports are associated with ? 12 months of mefenamic acid therapy and the anaemia is

reversible with discontinuation of treatment.

Diarrhoea: although this may occur soon after starting treatment, it may also occur after several months of continuos

use. If diarrhoea persists then inflammatory bowel disease should be excluded; if present mefenamic acid must be

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Date Printed 01/02/2010 CRN 2070139 page number: 7

Note: A positive reaction in certain tests for bile in the urine of patients receiving mefenamic acid has been

demonstratd to be due to the presence of the drug and its metabolites and not to the presence of bile.

d) Adverse reactions which may not have been observed but which are generally accepted as being attributable to other

Hypersensitivity: Hypersensitivity reactions have been reported following treatment with NSAIDs. These may consist

of (a) non-specific allergic reactions and anaphylaxis (b) respiratory tract reactivity comprising asthma, aggravated

asthma, bronchospasm, or dyspnoea or (c) assorted skin disorders including rashes of various types, pruritus, urticaria,

purpura, angiodema, and more rarely exfoliative or bullous dermatoses, including epidermal necrolysis, toxic epidermal

necrolysis (Lyell’s syndrome), erythema multiforme and Stevens-Johnson syndrome.

Neurological and special senses: Visual disturbances, optic neuritis, paraesthesia reports of aseptic meningitis

(especially in patients with existing auto-immune disorders, such as systemic lupus erythematosus, mixed connective

tissue disease), with symptoms such as stiff neck, headache, nausea, vomiting, fever or disorientation (see section 4.4),

depression, confusion, hallucinations, tinnitus, vertigo, malaise, fatigue and drowsiness.

Cardiovascular: Oedema, hypertension and cardiac failure have been reported in association with NSAID treatment.

Clinical trial and epidemiological data suggest that use of some NSAIDs (particularly at high doses and in long term

treatment)may be associated with an increased risk of arterial thrombotic events (for example myocardial infarction or

stroke) (see section 4.4).

Gastrointestinal: The most commonly observed adverse events are gastrointestinal in nature. Peptic ulcers, perforation

or GI bleeding, sometimes fatal, particularly in the elderly, may occur (see section 4.4). Nausea, vomiting, diarrhoea,

flatulence, constipation, dyspepsia, abdominal pain, melaenia, haematemesis, ulcerative stomatitis, exacerbation of

colitis and Crohn’s disease have been reported following administration. Less frequently, gastritis has been observed.

Additional information on special populations

Elderly or debilitated patients seem to tolerate gastrointestinal ulceration or bleeding less well than other individuals

and most spontaneous reports of fatal GI events are in this population.

Renal toxicity has been seen in patients with pre-renal conditions leading to a reduction in renal blood flow or blood

volume. Patients at greatest risk of this reaction are those with impaired renal function, heart failure, liver dysfunction,

those taking diuretics and the elderly.

Gastric lavage in the conscious patients and intense supportive therapy where necessary. Vital functions should be

monitored and supported. Activated charcoal has been shown to be a powerful absorbent for Mefenamic Acid and its

metabolites. Studies in experimental animals and human volunteers have shown that a 5 to 1 ratio of charcoal to

mefenamic acid results in considerable suppression of absorption of the drug. Haemodialysis is of little value since

mefenamic acid and its metabolites are firmly bound to plasma proteins. Overdose has led to fatalities.

Mefenamic acid has a tendency to induce tonic-clonic (grand mal) convulsions in overdose. Acute renal failure and

coma have been reported with mefenamic acid overdose. It is important that the recommended dose is not exceeded

and the regime adhered to since some reports have been involved daily dosages under 3g.

5 PHARMACOLOGICAL PROPERTIES

5.1 Pharmacodynamic properties

Pharmacotherapeutic group: Fenamates, ATC code: M01AG01

Irish Medicines Board

Date Printed 01/02/2010 CRN 2070139 page number: 8

Mefenamic acid is a non-steroidal anti-inflammatory drug (NSAID with anti-inflammatory, analgesic and antipyretic

Its anti-inflammatory effect was first established in the UV erythema model of inflammation. Further studies included

inhibition of granulation tissue growth into subcutaneous cotton pellets in rats and carrageenan induced rat paw oedema

Antipyretic activity was demonstrated in yeast-induced pyresis in rats. In this model its antipyretic activity was roughly

equal to that of phenylbutazone and flufenamic acid, but less than that of indomethacin.

Analgesic activity was demonstrated in tests involving pain sensitivity of rats paws inflamed by brewers yeast.

Mefenamic acid was less potent than flufenamic acid in this model.

Prostaglandins are implicated in a number of disease processes including inflammation, modulation of the pain

response, dysmenorrhoea, menorrhagia and pyrexia.

In common with most NSAIDs in the rat paw oedema test has been correlated with their ability to inhibit prostaglandin

synthetase. When mefenamic acid is ranked in both these tests it falls between indomethacin and phenylbutazone and it

is probable that inhibition of prostaglandin synthesis contributes to the pharmacological activity and clinical efficacy of

There is also considerable evidence that the fenamates inhibit the action of prostaglandins after they have been formed.

They therefore both inhibit the synthesis and response to prostaglandins. This double blockade may well be important

in their mode of action.

5.2 Pharmacokinetic properties

Absorption and distribution: Mefenamic acid is absorbed from the gastrointestinal tract. Peak levels of 10mg/l occur

two hours after the administration of a 1g oral dose to adults.

Metabolism: Mefenamic acid is extensively metabolised, firt to a 3 hyroxymethyl derivative (metabolite I) and then a 3

carboxyl derivative (metabolite II). Both metabolites undergo secondary conjugation to form glucuronides.

Elimination. Fifty two percent of a dose is recovered from the urine, 6% as mefenamic acid, 25% as metabolite I and

21% as metabolite II. Assay of stools over a 3 day period accounted for 10 – 20% of the dose chiefly as unconjugated

The plasma levels of unconjugated mefenamic acid decline with a half life of approximately two hours.

5.3 Preclinical safety data

Pre-clinical safety data does not add anything of further significance to the prescriber.

6 PHARMACEUTICAL PARTICULARS

6.1 List of excipients

Sodium starch glycollate Type A

Irish Medicines Board

Date Printed 01/02/2010 CRN 2070139 page number: 9

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Ivermectina Medlineplus Medicinas, Detebencil

Ivermectina

?Para cuales condiciones o enfermedades se prescribe este medicamento?

La ivermectina esta indicada para el tratamiento de la estrongiloidiasis (nematodo; infeccion causada por un tipo de parasito que entra al organismo penetrando la piel, llega a las vias respiratorias y se aloja en el intestino). La ivermectina se usa tambien para controlar la oncocercosis (ceguera de los rios; infeccion con un tipo de parasito que provoca sarpullido, protuberancias debajo de la piel y problemas de la vista, como perdida de vision o ceguera). La ivermectina pertenece a una clase de medicamentos llamados antihelminticos. En el caso de la estrongiloidiasis, actua destruyendo los parasitos presentes en el intestino. En el caso de la oncocercosis, destruye los parasitos en desarrollo. La ivermectina no mata los parasitos que causan la oncocercosis y, por lo tanto, no cura este tipo de infeccion.

?Como se debe usar este medicamento?

La ivermectina viene en forma de tabletas para administracion por via oral. Por lo general se toma una dosis unica en ayunas, con agua. Si toma ivermectina para el tratamiento de la oncocercosis, es posible que necesite otras dosis a los 3, 6 o 12 meses para controlar la infeccion. Siga al pie de la letra las instrucciones de la receta y pidales a su medico o farmaceutico que le expliquen cualquier cosa que no entienda. Tome la ivermectina tal como se lo indiquen. No aumente ni disminuya la dosis, ni la tome con mas frecuencia que la indicada por su medico.

Si toma ivermectina para el tratamiento de la estrongiloidiasis, tendra que hacerse analisis de materia fecal al menos tres veces durante los primeros 3 meses despues del tratamiento para determinar si la infeccion ha desaparecido. Si la infeccion persiste, es probable que el medico le recete otras dosis de ivermectina.

?Que otro uso se le da a este medicamento?

La ivermectina tambien se usa a veces para tratar algunas otras infecciones por parasitos, infestacion de piojos de la cabeza o del pubis, y sarna (afeccion cutanea que se caracteriza por prurito, causada por pequenos acaros que viven debajo de la piel). Consulte a su medico sobre los riesgos de este medicamento para tratar su problema.

A veces se receta este medicamento para otros usos; pidale mas informacion a su medico o farmaceutico.

?Cuales son las precauciones especiales que debo seguir?

Antes de tomar ivermectina,

informe a su medico y a su farmaceutico si es alergico a la ivermectina o a cualquier otro medicamento.

informe a su medico y farmaceutico que otros medicamentos con y sin receta, vitaminas, suplementos nutricionales y productos herbales esta tomando o piensa tomar. No olvide mencionar si esta tomando medicamentos para tratar la ansiedad, enfermedades mentales o convulsiones; relajantes musculares; sedantes; pildoras para dormir o tranquilizantes. Es posible que su medico deba cambiar la dosis de sus medicamentos o vigilarle estrechamente por si presentara efectos secundarios.

informe a su medico si tiene o alguna vez ha tenido meningitis, tripanosomiasis humana africana (enfermedad del sueno; infeccion que se transmite por la picadura de la mosca tsetse en ciertos paises africanos) o trastornos que afectan el sistema inmunologico, como el virus de la inmunodeficiencia humana (VIH).

informe a su medico si esta embarazada, planea estarlo o esta amamantando. Si queda embarazada durante el tratamiento con ivermectina, llame a su medico.

preguntele a su medico si es prudente consumir bebidas alcoholicas mientras esta tomando ivermectina.

si toma ivermectina para la oncocercosis, tenga en cuenta que puede tener mareos, vertifo y desvanecimiento si se incorpora con rapidez despues de haber estado acostado. Para evitar este problema, levantese de la cama lentamente y apoye los pies en el piso unos minutos antes de incorporarse. si toma ivermectina para la estrongiloidiasis y ha tenido loiasis (infeccion por Loa loa . causada por un tipo de gusano que ocasiona problemas de la piel y los ojos) o si alguna vez vivio o viajo en las regiones de Africa Occidental o Central donde la loiasis es comun, debe tener en cuenta que podria tener una reaccion grave. Llame a su medico de inmediato si se presenta vision borrosa, dolor de cabeza o cuello, convulsiones o dificultad para caminar o estar de pie.

?Que dieta especial debo seguir mientras tomo este medicamento?

La ivermectina puede provocar efectos secundarios. Informe a su medico si cualquiera de estos sintomas es grave o no desaparece:

mareos

perdida de apetito

nauseas

vomitos

dolor o hinchazon estomacal

diarrea

estrenimiento

debilidad

somnolencia

temblor incontrolable de alguna parte del cuerpo

molestias en el pecho

Si toma ivermectina para tratar la oncocercosis, tambien puede presentar los siguientes efectos secundarios. Informe a su medico si cualquiera de estos sintomas es grave o no desaparece:

hinchazon de ojos, cara, brazos, manos, pies, tobillos o pantorrillas

dolor e inflamacion en las articulaciones

dolor e inflamacion de las glandulas del cuello, axilas o entrepierna

frecuencia cardiaca acelerada

dolor, enrojecimiento o lagrimeo de ojos

hinchazon de ojos o parpados

sensacion anormal en los ojos

Algunos efectos secundarios pueden ser graves. Si presenta alguno de estos sintomas, llame a su medico de inmediato:

fiebre

ampollas o descamacion de la piel

sarpullido

urticaria

comezon

La ivermectina puede ocasionar otros efectos secundarios. Llame a su medico si tiene algun problema inesperado mientras toma este medicamento.

Si desarrolla un efecto secundario grave, usted o su doctor puede enviar un informe al programa de divulgacion de efectos adversos 'MedWatch' de la Administracion de Alimentos y Medicamentos (FDA, por su sigla en ingles) en la pagina de Internet (http://www. fda. gov/Safety/MedWatch ) o por telefono al 1-800-332-1088.

?Como debo almacenar o desechar este medicamento?

Mantenga este producto en su envase original, perfectamente cerrado y fuera del alcance de los ninos. Guardelo a temperatura ambiente y alejado del calor y la humedad excesivos (nunca en el cuarto de bano). Deseche todos los medicamentos vencidos o que ya no necesite. Preguntele a su farmaceutico cual es la manera adecuada de desechar los medicamentos.

?Que debo hacer en caso de una sobredosis?

En caso de una sobredosis, llame a la oficina local de control de envenenamiento al 1-800-222-1222. Si la victima esta inconsciente, o no respira, llame inmediatamente al 911.

Los sintomas de sobredosis son, entre otros:

sarpullido

urticaria

convulsiones

dolor de cabeza

hormigueo en pies o manos

debilidad

perdida de coordinacion

dolor de estomago

nauseas

vomitos

diarrea

mareos

falta de aliento

hinchazon de cara, brazos, manos, pies, tobillos o pantorrillas

?Que otra informacion de importancia deberia saber?

Asista a todas las citas con su medico y el laboratorio. Es posible que su medico ordene ciertas pruebas de laboratorio para verificar la respuesta de su organismo a la ivermectina.

No permita que ninguna otra persona use sus medicamentos. Es posible que no pueda volver a surtir esta receta.

Es importante que Ud. mantenga una lista escrita de todas las medicinas que Ud. esta tomando, incluyendo las que recibio con receta medica y las que Ud. compro sin receta, incluyendo vitaminas y suplementos de dieta. Ud. debe tener la lista cada vez que visita su medico o cuando es admitido a un hospital. Tambien es una informacion importante en casos de emergencia.

Marcas comerciales

Buy Odizol - Omeprazole - Online Without Prescriptions, Odizol

Prilosec (Odizol)

Prilosec is used for treating heartburn or irritation of the esophagus caused by gastroesophageal reflux disease (GERD). It may also be used for short-term treatment of ulcers of the stomach or small intestines. It may also be used with certain antibiotics to treat ulcers of the small intestines and to help prevent them from coming back. It may also be used to treat conditions that cause your body to make too much stomach acid (eg, Zollinger-Ellison syndrome). Prilosec is a proton pump inhibitor (PPI). It works by decreasing the amount of acid produced in the stomach.

Use Prilosec as directed by your doctor.

Take Prilosec by mouth on an empty stomach before eating.

Swallow Prilosec whole. Do not break, crush, chew, or open Prilosec before swallowing.

If you have trouble swallowing the capsule, add 1 tablespoon of applesauce to an empty bowl. Open the capsule and empty the pellets onto the applesauce. Mix the pellets with the applesauce and swallow the mixture at once, followed by a glass of cool water. The applesauce used should not be hot and should be soft enough to be swallowed with out chewing. Do not chew or crush the pellets. Do not store the mixture for further use.

You may take antacids while you are using Prilosec if you are directed to do so by your doctor.

If you also take an imidazole antifungal (eg, ketoconazole), take it at least 2 hours before taking Prilosec.

If you also take sucralfate, take Prilosec at least 30 minutes before taking sucralfate.

Continue to take Prilosec even if you feel well. Do not miss any doses.

If you miss a dose of Prilosec, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Prilosec.

Active Ingredient: Omeprazole.

Store Prilosec at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Prilosec out of the reach of children and away from pets.

Do NOT use Prilosec if:

you are allergic to any ingredient in Prilosec

you are taking an HIV protease inhibitor (eg, atazanavir).

Contact your doctor right away if any of these apply to you.

Some medical conditions may interact with Prilosec. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have liver problems or stomach or bowel cancer.

Some medicines may interact with Prilosec. Tell your health care provider if you are taking any other medicines, especially any of the following:

Clarithromycin or voriconazole because they may increase the risk of Prilosec's side effects

Anticoagulants (eg, warfarin), benzodiazepines (eg, diazepam), cilostazol, cyclosporine, digoxin, disulfiram, phenytoin, or tacrolimus because the risk of their side effects may be increased by Prilosec

Ampicillins, azole antifungals (eg, ketoconazole), clopidogrel, ginkgo biloba, HIV protease inhibitors (eg, atazanavir), or iron because their effectiveness may be decreased by Prilosec.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Prilosec may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Prilosec may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Prilosec with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Contact your doctor if you have any symptoms of a bleeding ulcer, such as black, tarry stools or vomit that looks like coffee grounds, or if you experience throat pain, chest pain, severe stomach pain, or trouble swallowing.

Prilosec may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Prilosec.

Prilosec should be used with caution in Asian patients; the risk of side effects may be increased in these patients.

Prilosec should be used with extreme caution in children younger than 2 years old; safety and effectiveness in these children have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Prilosec while you are pregnant. Prilosec is found in breast milk. Do not breastfeed while taking Prilosec.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); chest pain; dark urine; fast or irregular heartbeat; fever, chills, or sore throat; red, swollen, blistered, or peeling skin; swelling of the hands, ankles, or feet; unusual bruising or bleeding; unusual tiredness; vision changes; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

Drug Status

Imipramine Medlineplus Drug Information, Amipramidine

Imipramine

IMPORTANT WARNING:

A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants ('mood elevators') such as imipramine during clinical studies became suicidal (thinking about harming or killing oneself or planning or trying to do so). Children, teenagers, and young adults who take antidepressants to treat depression or other mental illnesses may be more likely to become suicidal than children, teenagers, and young adults who do not take antidepressants to treat these conditions. However, experts are not sure about how great this risk is and how much it should be considered in deciding whether a child or teenager should take an antidepressant. Children younger than 18 years of age should not normally take imipramine except to prevent bedwetting, but in some cases, a doctor may decide that imipramine is the best medication to treat a child's condition.

You should know that your mental health may change in unexpected ways when you take imipramine or other antidepressants even if you are an adult over 24 years of age. You may become suicidal, especially at the beginning of your treatment and any time that your dose is increased or decreased. You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: new or worsening depression; thinking about harming or killing yourself, or planning or trying to do so; extreme worry; agitation; panic attacks; difficulty falling asleep or staying asleep; aggressive behavior; irritability; acting without thinking; severe restlessness; and frenzied abnormal excitement. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own.

Your healthcare provider will want to see you often while you are taking imipramine, especially at the beginning of your treatment. Be sure to keep all appointments for office visits with your doctor.

The doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with imipramine. Read the information carefully and ask your doctor or pharmacist if you have any questions. You also can obtain the Medication Guide from the FDA website: http://www. fda. gov/Drugs/DrugSafety/InformationbyDrugClass/UCM096273 .

No matter your age, before you take an antidepressant, you, your parent, or your caregiver should talk to your doctor about the risks and benefits of treating your condition with an antidepressant or with other treatments. You should also talk about the risks and benefits of not treating your condition. You should know that having depression or another mental illness greatly increases the risk that you will become suicidal. This risk is higher if you or anyone in your family has or has ever had bipolar disorder (mood that changes from depressed to abnormally excited) or mania (frenzied, abnormally excited mood) or has thought about or attempted suicide. Talk to your doctor about your condition, symptoms, and personal and family medical history. You and your doctor will decide what type of treatment is right for you.

Why is this medication prescribed?

Imipramine tablets and capsules are used to treat depression. Imipramine tablets are also used to prevent bedwetting in children. Imipramine is in a class of medications called tricyclic antidepressants. It treats depression by increasing the amounts of certain natural substances in the brain that are needed to maintain mental balance. There is not enough information to explain how imipramine prevents bedwetting.

How should this medicine be used?

Imipramine comes as a tablet and a capsule to take by mouth. When imipramine tablets or capsules are used to treat depression, they are usually taken one or more times a day and may be taken with or without food. When imipramine tablets are used to prevent bedwetting in children, they are usually taken one hour before bedtime. Children who wet the bed early in the evening may be given one dose in the mid-afternoon and another dose at bedtime. Try to take imipramine at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take imipramine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor may start you on a low dose of imipramine and gradually increase your dose.

It may take 1-3 weeks or longer for you to feel the full benefit of imipramine. Continue to take imipramine even if you feel well. Do not stop taking imipramine without talking to your doctor. Your doctor will probably want to decrease your dose gradually.

Other uses for this medicine

Imipramine is also used occasionally to treat eating disorders and panic disorders. Talk to your doctor about the possible risks of using this medication for your condition.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking imipramine,

tell your doctor and pharmacist if you are allergic to imipramine, any other medications, or any of the ingredients in imipramine tablets or capsules. Ask your doctor or pharmacist for a list of the ingredients.

tell your doctor if you are taking a monoamine oxidase (MAO) inhibitor such as isocarboxazid (Marplan), linezolid (Zyvox), methylene blue, phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate), or if you have stopped taking an MAO inhibitor within the past 14 days. Your doctor will probably tell you not to take imipramine. If you stop taking imipramine, you should wait at least 14 days before you start to take an MAO inhibitor.

tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: anticoagulants (blood thinners) such as warfarin (Coumadin, Jantoven); antihistamines; cimetidine (Tagamet); flecainide (Tambocor); levodopa (Sinemet, Larodopa); lithium (Eskalith, Lithobid); medication for high blood pressure, mental illness, nausea, seizures, Parkinson's disease, asthma, colds, or allergies; methylphenidate (Ritalin); muscle relaxants; propafenone (Rhythmol); quinidine; sedatives; selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), paroxetine (Paxil), and sertraline (Zoloft); sleeping pills; thyroid medications; and tranquilizers. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Your doctor may tell you not to take imipramine if you have taken fluoxetine in the past 5 weeks.

tell your doctor if you have recently had a heart attack. Your doctor may tell you not to take imipramine.

tell your doctor if you are being treated with electroshock therapy (procedure in which small electric shocks are administered to the brain to treat certain mental illnesses), and if you have or have ever had an enlarged prostate (a male reproductive gland), difficulty urinating, seizures, an overactive thyroid gland, or liver, kidney, or heart disease.

tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking imipramine, call your doctor.

if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking imipramine.

you should know that this medication may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you.

remember that alcohol can add to the drowsiness caused by this medication.

tell your doctor if you use tobacco products. Cigarette smoking may decrease the effectiveness of this medication.

plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Imipramine may make your skin sensitive to sunlight.

you should know that imipramine may cause angle-closure glaucoma (a condition where the fluid is suddenly blocked and unable to flow out of the eye causing a quick, severe increase in eye pressure which may lead to a loss of vision). Talk to your doctor about having an eye examination before you start taking this medication. If you have nausea, eye pain, changes in vision, such as seeing colored rings around lights, and swelling or redness in or around the eye, call your doctor or get emergency medical treatment right away.

What special dietary instructions should I follow?

Imipramine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

nausea

drowsiness

weakness or tiredness

excitement or anxiety

nightmares

dry mouth

skin more sensitive to sunlight than usual

changes in appetite or weight

constipation

difficulty urinating

frequent urination

changes in sex drive or ability

excessive sweating

Some side effects can be serious. If you experience any of the following symptoms or those listed in the IMPORTANT WARNING or SPECIAL PRECAUTIONS sections, call your doctor immediately or get emergency medical treatment:

jaw, neck, and back muscle spasms

slow or difficult speech

shuffling walk

uncontrollable shaking of a part of the body

fever, sore throat, or other signs of infection

difficulty breathing or swallowing

severe rash

yellowing of the skin or eyes

irregular heartbeat

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www. fda. gov/Safety/MedWatch ) or by phone (1-800-332-1088).

Imipramine may cause other side effects. Tell you doctor if you have any unusual problems while you are taking this medication.

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

In case of emergency/overdose

Ranimerck Generic Name Ranitidine Online, Ranimerck

Ranimerck General Information

Ranimerck - Pharmacology:

The H2 antagonists are competitive inhibitors of histamine at the parietal cell H2 receptor. They suppress the normal secretion of acid by parietal cells and the meal-stimulated secretion of acid. They accomplish this by two mechanisms: histamine released by ECL cells in the stomach is blocked from binding on parietal cell H2 receptors which stimulate acid secretion, and other substances that promote acid secretion (such as gastrin and acetylcholine) have a reduced effect on parietal cells when the H2 receptors are blocked.

Ranimerck for patients

Phenylketonurics: ZANTAC 25 EFFERdose Tablets contain phenylalanine 2.81 mg per 25 mg of ranitidine. ZANTAC 150 EFFERdose Tablets contain phenylalanine 16.84 mg per 150 mg of ranitidine. ZANTAC EFFERdose Tablets should not be chewed, swallowed whole, or dissolved on the tongue.

This description is suitable for active ingredient Ranitidine

Ranimerck Interactions

Coadministration of TRITEC with clarithromycin resulted in increased plasma ranitidine concentrations (57%), increased plasma bismuth trough concentrations (48%), and increased 14- hydroxy - clarithromycin plasma concentrations (31%). Coadministration with aspirin results in a slight decrease in the rate of salicylate absorption that is clinically unimportant. Coadministration with a high dose of antacid (170 mEq) results in a 28% decrease in plasma concentrations of ranitidine and may decrease plasma concentrations of bismuth from TRITEC. These effects are clinically insignificant.

For information on drug interactions associated with ranitidine, refer to the ZANTAC ® package insert.

Ranimerck Contraindications

TRITEC is contraindicated in patients known to have hypersensitivity to ranitidine bismuth citrate or any of its ingredients.

For information on clarithromycin contraindications, see clarithromycin package insert.

This description is suitable for active ingredient Ranitidine

Generic name, Overdose, Half Life Ranimerck, Food Interactions, Chemical, etc..

Ranimerck see also

Dologesic Indications, Side Effects, Warnings, Dologesic

Dologesic

Dologesic is used for:

Treating mild to moderate aches and pains associated with headache, muscle and joint soreness, backache, menstrual cramps, colds and flu, sinusitis, toothache, and minor pain from arthritis, and to reduce fever. It may also be used for other conditions as determined by your doctor.

Dologesic is an analgesic, antihistamine, and antipyretic combination. It works by blocking substances in the body that cause fever, pain, and inflammation. It also blocks histamine, which causes sneezing and itchy, watery eyes.

Do NOT use Dologesic if:

you are allergic to any ingredient in Dologesic

you are taking sodium oxybate (GHB)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Dologesic:

Some medical conditions may interact with Dologesic. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have bleeding problems, blood vessel problems in the brain, a blockage of the stomach or bowel, a blockage of the bladder, or difficulty urinating

if you have lung problems (eg, asthma, emphysema, chronic obstructive pulmonary disease [COPD]), an enlarged prostate, glaucoma, kidney problems, or liver problems

Some MEDICINES MAY INTERACT with Dologesic. Tell your health care provider if you are taking any other medicines, especially any of the following:

Isoniazid, monoamine oxidase (MAO) inhibitors (eg, phenelzine), or sodium oxybate (GHB) because the risk of side effects may be increased

Anticoagulants (eg, warfarin) because the risk of side effects, including the risk of bruising or bleeding, may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Dologesic may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Dologesic:

Use Dologesic as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Dologesic may be taken with or without food.

If you miss a dose of Dologesic and you are using it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Dologesic.

Important safety information:

Dologesic may cause drowsiness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Dologesic. Using Dologesic alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.

Dologesic contains acetaminophen. Before you begin taking any new prescription or nonprescription medicine, read the ingredients to see if it also contains acetaminophen. If it does or if you are uncertain, contact your doctor or pharmacist.

Avoid taking medicines that cause drowsiness (eg, sedatives, tranquilizers) while taking Dologesic. Dologesic will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants.

Do not exceed the recommended dosage or take Dologesic for longer than prescribed without checking with your doctor.

If you consume 3 or more alcohol-containing drinks every day, ask your doctor whether you should take Dologesic or other pain relievers/fever reducers. Acetaminophen may cause liver damage. Alcohol use combined with Dologesic may increase your risk for liver damage.

A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.

If you are taking Dologesic for pain or fever and your symptoms do not improve within 10 days or if they become worse, check with your doctor.

Before you have any medical or dental treatments or surgery, tell the doctor or dentist that you are taking Dologesic.

Caution is advised when using Dologesic in CHILDREN because they may be more sensitive to its effects.

PREGNANCY and BREAST-FEEDING: It is unknown if Dologesic can cause harm to the fetus. If you become pregnant, discuss with your doctor the benefits and risks of using Dologesic during pregnancy. Dologesic is excreted in breast milk. Do not breast-feed while taking Dologesic.

Possible side effects of Dologesic:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Drowsiness; dry mouth, nose, or throat; heartburn; nausea; thickening of mucus in the nose and throat; upset stomach.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; dark urine or pale stools; decreased urination; severe stomach pain; unusual bruising or bleeding; unusual tiredness; vomiting; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA .

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center. or emergency room immediately. Symptoms may include abnormal behavior; dark urine; excessive sweating; extreme tiredness; fast or deep breathing; loss of consciousness; ringing in the ears; stomach pain; vomiting.

Proper storage of Dologesic:

Store Dologesic at room temperature, 77 degrees F (25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Dologesic out of the reach of children and away from pets.

General information:

If you have any questions about Dologesic, please talk with your doctor, pharmacist, or other health care provider.

Dologesic is to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Dologesic or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Dologesic. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Dologesic. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Dologesic.

Review Date: August 8, 2016

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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Click for further information on drug naming conventions and International Nonproprietary Names .

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