Terbiderm 10gm Cream ( Sun ) - Buy Terbiderm 10gm Cream Online At Best Price In India, Terbiderm

TERBIDERM 10GM CREAM

This medication is an antifungal agent, prescribed for jock itch, athletes foot and other types of ringworm infections. It works by stopping the growth of fungi.

How does Terbinafine work:

Terbinafine works to harm the yeast and fight the infection.

How should Terbinafine be used:

It comes as a tablet to take by mouth, with or without food. It also comes as an ointment, cream, and solution to apply topically. Adults: Toenail - 250 mg once daily for 12 weeks. Cream: Local application once or twice daily over the affected skin area.

Common side effects of Terbinafine :

Headache. Belly pain. Upset stomach or throwing up. Many small meals, good mouth care, sucking hard, sugar-free candy, or chewing sugar-free gum may help. Loose stools (diarrhea). Bad taste in your mouth. This most often goes back to normal. Harm to the liver may rarely happen.

What do I do if I miss a dose

Take a missed dose as soon as you think about it. If it is close to the time for your next dose, skip the missed dose and go back to your normal time. Do not take 2 doses at the same time or extra doses. Do not change the dose or stop this drug. Talk with the doctor.

What precautions should I take when taking Terbinafine :

If you have an allergy to terbinafine or any other part of this drug. Tell your doctor if you are allergic to any drugs. Make sure to tell about the allergy and what signs you had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs. If you have any of these health problems: Kidney disease or liver disease. If you are pregnant or may be pregnant. If you are breast-feeding.

When do I need to seek medical help

If you think there was an overdose, call your local poison control center or ER right away. Signs of a very bad reaction to the drug. These include wheezing; chest tightness; fever; itching; bad cough; blue or gray skin color; seizures; or swelling of face, lips, tongue, or throat. Very bad belly pain. Very upset stomach or throwing up. Not able to eat. A big weight gain. Dark urine or yellow skin or eyes. Feeling very tired or weak. Sudden change in eyesight, eye pain, or irritation. Any rash. Side effect or health problem is not better or you are feeling worse.

Can I take Terbinafine with other medicines:

Sometimes drugs are not safe when you take them with certain other drugs and food. - Taking them together can cause bad side effects. - Be sure to talk to your doctor about all the drugs you take.

Are there any food restrictions

How do I store Terbinafine :

Store in a cool, dry place away from the reach of children. - Medicines must not be used past the expiry date.

Pregnancy Category

Category B. Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.

Therapeutic Classification

Antifungals, Topical Antifungals & Antiparasites

This medication is an antifungal agent, prescribed for jock itch, athletes foot and other types of ringworm infections. It works by stopping the growth of fungi.

Raticina, Raticina

Raticina

Raticina - General Information

A non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers. [PubChem]

Pharmacology of Raticina

Raticina is a histamine H2-receptor antagonist similar to cimetidine and famotidine. An H2-receptor antagonist, often shortened to H2 antagonist, is a drug used to block the action of histamine on parietal cells in the stomach, decreasing acid production by these cells. These drugs are used in the treatment of dyspepsia, however their use has waned since the advent of the more effective proton pump inhibitors. Like the H1-antihistamines, the H2 antagonists are inverse agonists rather than true receptor antagonists.

Raticina for patients

Phenylketonurics: ZANTAC 25 EFFERdose Tablets contain phenylalanine 2.81 mg per 25 mg of ranitidine. ZANTAC 150 EFFERdose Tablets contain phenylalanine 16.84 mg per 150 mg of ranitidine. ZANTAC EFFERdose Tablets should not be chewed, swallowed whole, or dissolved on the tongue.

Raticina Interactions

Coadministration of TRITEC with clarithromycin resulted in increased plasma ranitidine concentrations (57%), increased plasma bismuth trough concentrations (48%), and increased 14- hydroxy - clarithromycin plasma concentrations (31%). Coadministration with aspirin results in a slight decrease in the rate of salicylate absorption that is clinically unimportant. Coadministration with a high dose of antacid (170 mEq) results in a 28% decrease in plasma concentrations of ranitidine and may decrease plasma concentrations of bismuth from TRITEC. These effects are clinically insignificant.

For information on drug interactions associated with ranitidine, refer to the ZANTAC ® package insert.

Raticina Contraindications

TRITEC is contraindicated in patients known to have hypersensitivity to ranitidine bismuth citrate or any of its ingredients.

For information on clarithromycin contraindications, see clarithromycin package insert.

Additional information about Raticina

Raticina Indication: Used in the treatment of peptic ulcer disease (PUD), dyspepsia, stress ulcer prophylaxis, and gastroesophageal reflux disease (GERD). Mechanism Of Action: The H2 antagonists are competitive inhibitors of histamine at the parietal cell H2 receptor. They suppress the normal secretion of acid by parietal cells and the meal-stimulated secretion of acid. They accomplish this by two mechanisms: histamine released by ECL cells in the stomach is blocked from binding on parietal cell H2 receptors which stimulate acid secretion, and other substances that promote acid secretion (such as gastrin and acetylcholine) have a reduced effect on parietal cells when the H2 receptors are blocked. Drug Interactions: Anisindione The anti-H2 increases the anticoagulant effect Dicumarol The anti-H2 increases the anticoagulant effect Acenocoumarol The anti-H2 increases the anticoagulant effect Warfarin The anti-H2 increases the anticoagulant effect Itraconazole The anti-H2 decreases the absorption of the imidazole Ketoconazole The anti-H2 decreases the absorption of the imidazole Procainamide The histamine H2-receptor antagonist increases the effect of procainamide Dasatinib Possible decreased levels of dasatinib Atazanavir This gastric pH modifier decreases the levels/effects of atazanaivr Tolazoline Anticipated loss of efficacy of tolazoline Food Interactions: Avoid alcohol. Avoid milk, calcium containing dairy products, iron, antacids, or aluminum salts 2 hours before or 6 hours after using antacids while on this medication. Avoid excessive quantities of coffee or tea (Caffeine). Generic Name: Ranitidine Synonyms: Ranitidine hydrochloride; Ranitidine HCL; Ranitidine Base; Rantidine HCL Drug Category: Anti-Ulcer Agents; Histamine H2 Antagonists Drug Type: Small Molecule; Approved Other Brand Names containing Ranitidine: Alquen; Alter-H2; Alvidina; Apo-Ranitidin; Artomil; Azuranit; Coralen; Digestosan; Ergan; Esofex; Fendibina; Gastrial; Gastridina; Gastrolav; Gastrosedol; Kuracid; Label; Lake; Logat; Melfax; Microtid; Mideran; Neugal; Noctone; Noktome; Normon; Novo-Radinine; Nu-Ranit; Pep-Rani; Ptinolin; Quadrin; Quantor; RAN; Radin; Ran H2; Ran Lich; Rani 2; Rani AbZ; Rani-BASF; Rani-Puren; Rani-Q; Rani-Sanorania; Rani-nerton; Raniben; Raniberl; Raniberta; Ranibloc; Ranic; Ranicux; Ranidil; Ranidin; Ranidine; Ranidura; Ranifur; Ranigasan; Ranigast; Ranigen; Ranilonga; Ranimerck; Raniogas; Raniplex; Ranisan; Ranitab; Ranitic; Ranitidin; Ranitidin 1A Pharma; Ranitidin AL; Ranitidin AWD; Ranitidin Arcana; Ranitidin Atid; Ranitidin Basics; Ranitidin Duncan; Ranitidin Dyna; Ranitidin Helvepharm; Ranitidin Heumann; Ranitidin Hexal; Ranitidin Merck; Ranitidin Millet; Ranitidin NM; Ranitidin Normon; Ranitidin PB; Ranitidin Stada; Ranitidin von ct; Ranitidin-Cophar; Ranitidin-Isis; Ranitidin-ratiopharm; Ranitidina Tamarang; Ranitidina predilu Grif; Ranitiget; Ranitin; Ranitine; Ranobel; Rantacid; Ranuber; Raticina; Regalil; Renatac; Rozon; Rubiulcer; Santanol; Serviradine; Sostril; Tanidina; Taural; Terposen; Toriol; Trigger; Ulcecur; Ulcex; Ulcirex; Ulcodin; Ulcolind Rani; Ulsaven; Ultidine; Viserul; Zandid; Zantac; Zantac 150; Zantac 75; Zantac In Plastic Container; Zantarac; Zantic; Absorption: Approximately 50% bioavailability orally. Toxicity (Overdose): LD 50 =77mg/kg (orally in mice). Symptoms of overdose include muscular tremors, vomiting, and rapid respiration. Protein Binding: 15% Biotransformation: Hepatic. Ranitidine is metabolized to the N-oxide, S-oxide, and N-desmethyl metabolites, accounting for approximately 4%, 1%, and 1% of the dose, respectively. Half Life: 2.8-3.1 hours Dosage Forms of Raticina: Solution Intravenous Tablet Oral Solution Oral Chemical IUPAC Name: (E)-N-[2-[[5-(dimethylaminomethyl)furan-2-yl]methylsulfanyl]ethyl]-N'-methyl-2-nitroethene-1,1-diamine Chemical Formula: C13H22N4O3S Ranitidine on Wikipedia: http://en. wikipedia. org/wiki/Ranitidine Organisms Affected: Humans and other mammals

PharmGKB contains no dosing guidelines for this. To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this. If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page.

Links in the "Gene" column lead to PharmGKB Gene Pages.

The following icons indicate that data of a certain type is available:

DG Dosing Guideline information is available DL Drug Label information is available CA High-level Clinical Annotation is available VA Variant Annotation is available VIP VIP information is available PW Pathway is available

Ranitidine Base

Ranitidine HCL

Ranitidine hydrochloride

Rantidine HCL

Alquen

Alter-H2

Alvidina

Apo-Ranitidin

Artomil

Azuranit

Coralen

Digestosan

Ergan

Esofex

Fendibina

Gastrial

Gastridina

Gastrolav

Gastrosedol

Kuracid

Lake

Logat

Melfax

Microtid

Mideran

Neugal

Noctone

Noktome

Normon

Novo-Radinine

Nu-Ranit

Pep-Rani

Ptinolin

Quadrin

Quantor

RAN

Radin

Ran H2

Ran Lich

Rani 2

Rani AbZ

Rani-BASF

Rani-Puren

Rani-Q

Rani-Sanorania

Rani-nerton

Raniben

Raniberl

Raniberta

Ranibloc

Ranic

Ranicux

Ranidil

Ranidin

Ranidine

Ranidura

Ranifur

Ranigasan

Ranigast

Ranigen

Ranilonga

Ranimerck

Raniogas

Raniplex

Ranisan

Ranitab

Ranitic

Ranitidin

Ranitidin 1A Pharma

Ranitidin AL

Ranitidin AWD

Ranitidin Arcana

Ranitidin Atid

Ranitidin Basics

Ranitidin Duncan

Ranitidin Dyna

Ranitidin Helvepharm

Ranitidin Heumann

Ranitidin Hexal

Ranitidin Merck

Ranitidin Millet

Ranitidin NM

Ranitidin Normon

Ranitidin PB

Ranitidin Stada

Ranitidin von ct

Ranitidin-Cophar

Ranitidin-Isis

Ranitidin-ratiopharm

Ranitidina Tamarang

Ranitidina predilu Grif

Ranitiget

Ranitin

Ranitine

Ranobel

Rantacid

Ranuber

Raticina

Regalil

Renatac

Rozon

Rubiulcer

Santanol

Serviradine

Sostril

Tanidina

Taural

Terposen

Toriol

Trigger

Tritec (ranitidine bismuth citrate salt)

Ulcecur

Ulcex

Ulcirex

Ulcodin

Ulcolind Rani

Ulsaven

Ultidine

Viserul

Zandid

Zantac

Zantac 150

Zantac 75

Zantac In Plastic Container

Zantarac

Zantic

Brand Mixture Names

PharmGKB Accession Id

Type(s):

Description

A non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers.

Source: Drug Bank

Indication

Used in the treatment of peptic ulcer disease (PUD), dyspepsia, stress ulcer prophylaxis, and gastroesophageal reflux disease (GERD).

Source: Drug Bank

Other Vocabularies

Information pulled from DrugBank has not been reviewed by PharmGKB.

Pharmacology, Interactions, and Contraindications

Mechanism of Action

The H2 antagonists are competitive inhibitors of histamine at the parietal cell H2 receptor. They suppress the normal secretion of acid by parietal cells and the meal-stimulated secretion of acid. They accomplish this by two mechanisms: histamine released by ECL cells in the stomach is blocked from binding on parietal cell H2 receptors which stimulate acid secretion, and other substances that promote acid secretion (such as gastrin and acetylcholine) have a reduced effect on parietal cells when the H2 receptors are blocked.

Source: Drug Bank

Pharmacology

Ranitidine is a histamine H2-receptor antagonist similar to cimetidine and famotidine. An H2-receptor antagonist, often shortened to H2 antagonist, is a drug used to block the action of histamine on parietal cells in the stomach, decreasing acid production by these cells. These drugs are used in the treatment of dyspepsia, however their use has waned since the advent of the more effective proton pump inhibitors. Like the H1-antihistamines, the H2 antagonists are inverse agonists rather than true receptor antagonists.

Source: Drug Bank

Food Interaction

Avoid alcohol.|Avoid milk, calcium containing dairy products, iron, antacids, or aluminum salts 2 hours before or 6 hours after using antacids while on this medication.|Avoid excessive quantities of coffee or tea (Caffeine).|Take without regard to meals.

Source: Drug Bank

Absorption, Distribution, Metabolism, Elimination & Toxicity

Biotransformation

Hepatic. Ranitidine is metabolized to the N-oxide, S-oxide, and N-desmethyl metabolites, accounting for approximately 4%, 1%, and 1% of the dose, respectively.

Source: Drug Bank

Excedrin Uses, Dosage - Side Effects, Excedrin

Excedrin

What is Excedrin?

Excedrin contains a combination of acetaminophen, aspirin, and caffeine. Acetaminophen is a pain reliever and a fever reducer. Aspirin is in a group of drugs called salicylates. It works by reducing substances in the body that cause pain, fever, and inflammation. Caffeine is a central nervous system stimulant. It relaxes muscle contractions in blood vessels to improve blood flow.

Excedrin is used to treat pain caused by tension headaches, migraine headaches, muscle aches, menstrual cramps, arthritis, toothaches, the common cold, or nasal congestion.

Excedrin may also be used for purposes not listed in this medication guide.

Important information

Do not give Excedrin to a child or teenager with a fever, flu symptoms, or chicken pox. Aspirin can cause Reye's syndrome, a serious and sometimes fatal condition in children.

Do not take more Excedrin than is recommended. An overdose of acetaminophen can damage your liver or cause death. Call your doctor at once if you have nausea, pain in your upper stomach, itching, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of your skin or eyes).

Aspirin may cause stomach or intestinal bleeding, which can be fatal. Call your doctor at once if you have symptoms such as bloody or tarry stools, or coughing up blood or vomit that looks like coffee grounds.

In rare cases, acetaminophen may cause a severe skin reaction. Stop taking Excedrin and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling.

Before taking this medicine

Do not give Excedrin to a child or teenager with a fever, flu symptoms, or chicken pox. Aspirin can cause Reye's syndrome, a serious and sometimes fatal condition in children.

You should not use Excedrin if you are allergic to acetaminophen (Tylenol), aspirin, caffeine, or any NSAIDs (Advil, Motrin, Aleve, Orudis, Indocin, Lodine, Voltaren, Toradol, Mobic, Relafen, Feldene, and others).

Aspirin may cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are taking Excedrin.

Ask a doctor or pharmacist if it is safe for you to take Excedrin if you have other medical conditions, especially:

liver disease, cirrhosis, a history of alcoholism, or if you drink more than 3 alcoholic beverages per day;

asthma or seasonal allergies;

fever with a stiff neck;

stomach ulcer, stomach or intestinal bleeding, ulcerative colitis;

a bleeding or blood clotting disorder such as hemophilia;

kidney disease; or

if you use medicine to treat glaucoma or prevent blood clots.

If you take Excedrin to treat headache pain, seek medical attention if you have:

a headache so bad you have to lie down;

a headache that causes vomiting;

what feels like the worst headache you've ever had;

a headache that seems different from your usual headaches;

a headache every day;

a headache after coughing, bending, exercising, or head injury;

if you have never had migraines diagnosed by a doctor; or

if you are having your first headache after age 50.

Aspirin may be harmful to an unborn baby's heart, and may also reduce birth weight or have other dangerous effects. Tell your doctor if you are pregnant or plan to become pregnant while you are taking Excedrin.

Aspirin, acetaminophen, and caffeine can pass into breast milk and may harm a nursing baby. You should not breast-feed while using Excedrin.

How should I take Excedrin?

Use Excedrin exactly as directed on the label, or as it has been prescribed by your doctor. Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death.

Take Excedrin with food or milk if it makes your stomach upset.

Call your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever lasting longer than 3 days, or any swelling or pain lasting longer than 10 days.

This medication can cause unusual results with certain lab tests for glucose (sugar) in the urine. Tell any doctor who treats you that you are using Excedrin.

If you need surgery, tell the surgeon ahead of time that you are using Excedrin. You may need to stop using the medicine for a short time.

Store Excedrin at room temperature away from moisture and heat.

What happens if I miss a dose?

Since Excedrin is used when needed, you may not be on a dosing schedule. If you are on a schedule, use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of acetaminophen can damage your liver or cause death.

The first signs of an acetaminophen overdose include loss of appetite, nausea, vomiting, stomach pain, sweating, and confusion or weakness. Later symptoms may include pain in your upper stomach, dark urine, and yellowing of your skin or the whites of your eyes.

Overdose symptoms may also include ringing in your ears, headache, diarrhea, hallucinations, fast or slow heart rate, or seizure (convulsions).

What should I avoid?

Avoid drinking alcohol while you are taking Excedrin. Alcohol may increase your risk of stomach bleeding while taking aspirin, or liver damage while taking acetaminophen.

Ask a doctor or pharmacist before using any other cough, cold, allergy, pain, menstrual symptom, or fever medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Aspirin and caffeine are also contained in many combination medicines. Check the label to see if a medicine contains acetaminophen, APAP, aspirin, or caffeine.

Avoid taking another NSAID (nonsteroidal anti-inflammatory drug) such as aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.

Avoid coffee, tea, cola, energy drinks or other sources of caffeine while taking this medication. They can add to the side effects of the caffeine in the medication.

Excedrin side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Excedrin: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

In rare cases, acetaminophen may cause a severe skin reaction that can be fatal. This could occur even if you have taken acetaminophen in the past and had no reaction. Stop taking Excedrin and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling. If you have this type of reaction, you should never again take any medicine that contains acetaminophen.

Stop using Excedrin and call your doctor at once if you have:

severe anxiety, agitation, confusion, panic;

easy bruising or bleeding;

a light-headed feeling, like you might pass out;

if you feel very thirsty or hot, are unable to urinate, and have heavy sweating or hot and dry skin;

symptoms of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;

high potassium--slow heart rate, weak pulse, muscle weakness, tingly feeling; or

liver problems--nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common Excedrin side effects may include:

upset stomach, heartburn;

depressed mood, feeling anxious or restless; or

sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Excedrin?

Other drugs may interact with Excedrin, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

More about Excedrin (acetaminophen / aspirin / caffeine)

Consumer resources

Other formulations

Related treatment guides

Where can I get more information?

Your pharmacist can provide more information about Excedrin.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Excedrin only for the indication prescribed.

Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2016 Cerner Multum, Inc. Version: 7.02. Revision Date: 2013-11-19, 5:10:11 PM.

Fucibet Lipid Cream, Fucibet

FUCIBET LIPID CREAM

Page 1 of 2 Pharmacode 446

Font size: Heading: 10 point, section: 9 point, linespacing: 3,3 mm

Mock-up for reg. purpose

Package leaflet: Information for the user

Fucibet Lipid cream ®

In this leaflet: 1. What Fucibet® is and what it is used for 2. What you need to know before you use Fucibet® 3. How to use Fucibet® 4. Possible side effects 5. How to store Fucibet® 6. Contents of the pack and other information

• If you are pregnant or think you might be pregnant; Fucibet® should not be used during pregnancy unless you are told to do so by your doctor. • If you are breast-feeding; Fucibet® may be used by women who are breast-feeding but the cream should not be applied to the breasts to avoid accidental ingestion by the infant. Tell your doctor if you become pregnant while using this medicine.

1. What Fucibet® is and what it is used for

Driving and using machines This medicine should not have any effect on your ability to drive or use machines. Check with your doctor if you feel any side effect that may stop you from driving or using machines.

Fucibet® contains 2 different types of medicine. One medicine is called fusidic acid. It is a type of antibiotic. The other medicine is called betamethasone valerate. It is a type of corticosteroid (steroid). These 2 medicines work at the same time in different ways. Fucibet® works by: • The antibiotic killing germs (bacteria) that cause infections. • The corticosteroid reducing any swelling, redness or itchiness of your skin. Fucibet® is used to treat: • Conditions where the skin is inflamed (eczema or dermatitis) and also infected by germs (bacteria).

2. What you need to know before you use Fucibet® Do not use Fucibet® • If you are allergic (hypersensitive) to fusidic acid or betamethasone valerate or to any of the other ingredients in your medicine. You can find a list of these ingredients in section 6 of this leaflet. • To treat a skin condition caused by a fungus, such as athlete’s foot. • To treat a skin condition caused by a virus, such as cold sores or chickenpox. • To treat skin conditions caused only by bacteria, such as boils or spots. • To treat skin conditions caused by tuberculosis (TB) or syphilis. • To treat a skin condition called perioral dermatitis. This is a red, spotty rash around your mouth or chin. • To treat a skin condition called rosacea. This is redness and inflammation over your nose and cheeks. Ask your doctor if you are unsure. Warnings and precautions Talk to your doctor or pharmacist before using Fucibet® • Do not use the cream on yourself or a child for more than 2 weeks; this is to avoid the bacteria becoming resistant to the antibiotic and to avoid the steroid causing you side effects. • Take special care if you are going to use this medicine near your eyes or the eyes of a child. If the cream gets into the eye, this may lead to glaucoma. • If you use the cream over a long time or in large amounts it may make the chance of getting any side effects or infections higher. Also your skin may get more sensitive to this medicine. • You must not use the medicine for a long time on your face. • Unless your doctor has told you to, you must not use Fucibet® on open wounds or sensitive areas such as the nostrils, ears, lips or genitals. • Unless your doctor has told you to, you must not use Fucibet® on thin skin, skin ulcers, broken veins or acne. • Adrenal suppression may occur. Signs are tiredness, depression and anxiety. This can be reversed by stopping Fucibet®. Other medicines and Fucibet® Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. This includes any medicines which you have bought without a prescription. Pregnancy and breast-feeding If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine.

Fucibet® contains • Cetostearyl alcohol. This may give you an itchy rash and inflammation on your skin where your medicine is used. • Potassium sorbate. This may give you an itchy rash and inflammation on your skin where your medicine is used. • Methylparahydroxybenzoate (E218) and propylparahydroxybenzoate (E216). These are preservatives. They may give you an allergic reaction. This may happen at any time after you have your medicine. Please read section 4 so you can spot any signs this may be happening to you. Please ask your doctor if you are worried about any of the ingredients in this medicine.

3. How to use Fucibet® Always use this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure. How to apply Fucibet® This medicine is only for use on your skin or the skin of a child over 6 years. Do not swallow it. Do not put it inside your body. Remove the cap. Check the seal is not broken before you first use the cream. Then push the spike in the cap through the seal on the tube. Always wash your hands before using Fucibet®. Rub the medicine gently on the skin. If you use it on your face be careful to avoid your eyes. Unless you are using the cream to treat your hands, always wash your hands after using Fucibet®. If you accidentally get any medicine in your eye, wash it out with cold water straight away. Then bathe your eye with eyewash if possible. Your eye may sting. If you start to have any problems with your sight or your eye is sore, contact your doctor immediately. How much Fucibet® to use Your doctor will tell you how much Fucibet® to use. The usual treatment time is up to 2 weeks. Ask your doctor before using this medicine for any longer. You should notice your skin improve after just a few days of using the cream. If there is no improvement after 7 days you should stop using the cream and go back to your doctor. Usually, you should use this medicine twice each day. Use it in the morning and evening. To remind you to use the medicine it may help to use it when you do another regular action, such as brushing your teeth. If you have been told to cover the skin with any dressings or bandages you may not need to use the medicine so often. Follow the advice of your doctor. Adults and children over 6 years: Your doctor should tell you the dose that is right for you or the child. If your doctor has told you the amount of cream to use then keep to this advice. If not, the following guide will help you to use the correct amount.

Read all of this leaflet carefully before you start using this medicine because it contains important information for you. • Keep this leaflet. You may need to read it again. • If you have any further questions, ask your doctor, pharmacist or nurse. • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours. • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4. • In this leaflet Fucibet® Lipid Cream will be called Fucibet®.

Fusidic acid and betamethasone valerate

Item-num See deta

Fucibet® Lipid cream

Face and neck: 21?2 fingertip units. Back: 7 fingertip units. Front: 7 fingertip units. One arm (not including the hand): 3 fingertip units.

Both sides of one hand: 1 fingertip unit. One leg (not including the foot): 6 fingertip units. One foot: 2 fingertip units.

For a child over 6 years and under 11 years:

5. How to store Fucibet® Arm Face Leg and neck and hand and foot

Child’s age 6-10 years

Back incl. buttocks

Number of fingertip units needed 2

If you use more Fucibet® than you should Tell your doctor straight away if you have used more Fucibet® than you should. You may need to stop taking this medicine. If you forget to use Fucibet® If you forget to use the cream at the right time, use it as soon as you remember. Then use this medicine again at the usual time. Do not take a double dose to make up for a forgotten dose. If you have any further questions about using this medicine, please ask your doctor or pharmacist.

4. Possible side effects Like all medicines, Fucibet® can cause side effects, although not everybody gets them. Important side effects to look out for: Tell your doctor or nurse immediately if any of the following happen. You may need to stop your treatment: • You have difficulty breathing • Your face or throat swell • Your skin develops a severe rash. The following less serious side effects have also been reported. If any of them last a long time or cause problems, you should tell your doctor or nurse as soon as possible. Any of the problems listed below are more likely if the medicine is used for a long time, in large amounts or on skin folds (such as armpits or under breasts). These problems are more likely in children. They are also more likely if the skin is covered with a dressing or bandage.

• Keep this medicine out of the sight and reach of children. • Do not use Fucibet® after the expiry date on the tube or carton. The expiry date is the last day of that month. • Do not store the medicine above 25°C. • Do not use the tube for more than 3 months after you first open it. Make a note of the date you first opened the tube in the space provided on the carton. Do not throw away any medicines via wastewater or household waste. Ask you pharmacist how to throw away any medicines you no longer use. These measures will help protect the environment.

6. Contents of the pack and other information What Fucibet® contains • The active substances are fusidic acid and betamethasone valerate. Fucibet® contains 2% fusidic acid and 0.1% betamethasone. • The other ingredients are steareth-21, cetostearyl alcohol, white soft paraffin, liquid paraffin, hypromellose, citric acid monohydrate, methylparahydroxybenzoate, propylparahydroxybenzoate, potassium sorbate, all-rac-?-tocopherol and purified water. You can find important information about some of the ingredients in your medicine near the end of section 2 of this leaflet. What Fucibet® looks like and contents of the pack Fucibet® is a white cream. Fucibet® comes in tubes of 5 g, 15 g, 30 g or 60 g. Not all pack sizes may be marketed. Marketing Authorisation Holder and Manufacturer Marketing Authorisation Holder: LEO Laboratories Limited, Hurley, Berkshire, SL6 6RJ, UK. Manufacturer: LEO Laboratories Limited, Dublin 12, Ireland. This leaflet was last revised in July 2015. ®Registered Trade Mark

Skin problems Uncommon (may affect up to 1 in 100 people) • Itchy rash and skin inflammation in the area where the medicine is used • Worsening of your eczema • Burning feeling • Itching • Dry skin • Application site pain • Application site irritation Rare (may affect up to 1 in 1,000 people) • Skin redness • Hives • Skin rash • Application site swelling • Application site blisters Some side effects are known to be caused by betamethasone valerate (steroid), one of the ingredients in Fucibet®. You should tell your doctor if any of the side effects occur: • Adrenal glands may stop working properly. Signs are tiredness, depression and anxiety. • Glaucoma • Thinning of the skin • Red, spotty rash around the mouth or chin • Stretch marks • Small veins near the surface of the skin become visible • Changes in growth of your body hair • Excessive sweating • Lightening of your skin colour • Redness and pimples around the mouth • Redness of the skin, nose or mouth • Formation of cataracts. Reporting of side effects If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www. mhra. gov. uk/yellowcard. By reporting side effects, you can help provide more information on the safety of this medicine.

You can use your first (index) finger to measure how much Fucibet® to use. Squeeze the cream along your finger from the tip to the first joint as shown in the diagram. This is called a fingertip unit. The usual number of fingertip units you need to cover different parts of the body is shown in the diagrams. If you need to use a little more or a little less do not worry. If you are using the cream on a child still use an adult finger to measure out the fingertip unit.

Item-number: See details below.

Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

Triampur Generic Name Triamterene Online, Triampur

Triampur General Information

Triampur - Pharmacology:

Triampur interferes with sodium reabsorption in the distal renal tubule by inhibiting sodium transport mechanisms directly. Specifically it inhibits the Na + /K + /2Cl - co-transporter. The result is an electrical-potential difference across the membrane that blocks the passive distal tubular secretion of potassium. Relative to other diuretics, triamterene has a unique mode of action as it inhibits the reabsorption of sodium ions in exchange for potassium and hydrogen ions at that segment of the distal tubule under the control of adrenal mineralocorticoids (especially aldosterone).

Triampur for patients

Information for Patients

To help avoid stomach upset, it is recommended that the drug be taken after meals.

If a single daily dose is prescribed, it may be preferable to take it in the morning to minimize the effect of increased frequency of urination on nighttime sleep.

If a dose is missed, the patient should not take more than the prescribed dose at the next dosing interval.

This description is suitable for active ingredient Triamterene

Triampur Interactions

Caution should be used when lithium and diuretics are used concomitantly because diuretic-induced sodium loss may reduce the renal clearance of lithium and increase serum lithium levels with risk of lithium toxicity. Patients receiving such combined therapy should have serum lithium levels monitored closely and the lithium dosage adjusted if necessary.

A possible interaction resulting in acute renal failure has been reported in a few subjects when indomethacin, a nonsteroidal anti-inflammatory agent, was given with triamterene. Caution is advised in administering nonsteroidal anti-inflammatory agents with triamterene.

The effects of the following drugs may be potentiated when given together with triamterene: antihypertensive medication, other diuretics, preanesthetic and anesthetic agents, skeletal muscle relaxants (nondepolarizing).

Potassium-sparing agents should be used with caution in conjunction with angiotensin-converting enzyme (ACE) inhibitors due to an increased risk of hyperkalemia.

The following agents, given together with triamterene, may promote serum potassium accumulation and possibly result in hyperkalemia because of the potassium-sparing nature of triamterene, especially in patients with renal insufficiency: blood from blood bank (may contain up to 30 mEq of potassium per liter of plasma or up to 65 mEq per liter of whole blood when stored for more than 10 days); low-salt milk (may contain up to 60 mEq of potassium per liter); potassium-containing medications (such as parenteral penicillin G potassium); salt substitutes (most contain substantial amounts of potassium).

Triampur may raise blood glucose levels; for adult-onset diabetes, dosage adjustments of hypoglycemic agents may be necessary during and after therapy; concurrent use with chlorpropamide may increase the risk of severe hyponatremia.

Drug/Laboratory Test Interactions

Triampur and quinidine have similar fluorescence spectra; thus, triamterene will interfere with the fluorescent measurement of quinidine.

Triampur Contraindications

Anuria, severe or progressive kidney disease or dysfunction with the possible exception of nephrosis. Severe hepatic disease. Hypersensitivity to the drug.

Triampur should not be used in patients with preexisting elevated serum potassium, as is sometimes seen in patients with impaired renal function or azotemia, or in patients who develop hyperkalemia while on the drug. Patients should not be placed on dietary potassium supplements, potassium salts, or potassium-containing salt substitutes in conjunction with triamterene.

Triampur should not be given to patients receiving other potassium-sparing agents such as spironolactone, amiloride hydrochloride, or other formulations containing triamterene. Two deaths have been reported in patients receiving concomitant spironolactone and triamterene or Dyazide. Although dosage recommendations were exceeded in one case and in the other serum electrolytes were not properly monitored, these two drugs should not be given concomitantly.

This description is suitable for active ingredient Triamterene

Triampur tags categories:

Normitab, Normitab

Normitab

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Benadryl is an antihistamine. Diphenhydramine blocks the effects of the naturally occurring chemical histamine in the body. It is used to treat sneezing; runny nose; itching, watery eyes; hives; rashes; and other symptoms of allergies and the common cold.

Availability: In Stock (14 packs)

Analogs of: Benadryl

Other names of Benadryl:

Benadryl is used for preventing or treating symptoms of hay fever and other upper respiratory allergies or the common cold, such as runny nose, sneezing, itching of the nose and throat, and itchy, watery eyes, and relieving cough.

Do not take Benadryl if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. A very dangerous drug interaction could occur, leading to serious side effects.

Before taking Benadryl, tell your doctor if you have:

glaucoma or increased pressure in the eye;

a stomach ulcer;

an enlarged prostate, bladder problems or difficulty urinating;

an overactive thyroid (hyperthyroidism);

hypertension or any type of heart problems; or

asthma.

You may not be able to take Benadryl, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.

Take Benadryl exactly as directed on the package or as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water.

Benadryl can be taken with or without food.

For motion sickness, a dose is usually taken 30 minutes before motion, then with meals and at bedtime for the duration of exposure.

As a sleep aid, Benadryl should be taken approximately 30 minutes before bedtime.

To ensure that you get a correct dose, measure the liquid forms of Benadryl with a special dose-measuring spoon or cup, not with a regular tablespoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.

Never take more of Benadryl than is prescribed for you. The maximum amount of diphenhydramine that you should take in any 24-hour period is 300 mg.

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of Benadryl unless otherwise directed by your doctor.

Do NOT use more than directed.

Adults and children 12 years of age and over - 25 mg to 50 mg (1 to 2 capsules).

Children 6 to under 12 years of age - 12.5 mg ** to 25 mg (1 capsule).

Children under 6 years of age - consult a doctor.

Store Benadryl at room temperature between 68 and 77 degrees F (20 and 25 degrees C) in a tightly closed container. Brief periods at temperatures of 59 to 86 degrees F (15 to 30 degrees C) are permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Benadryl out of the reach of children and away from pets.

Before taking diphenhydramine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: breathing problems (e. g. asthma, emphysema), glaucoma, heart problems, high blood pressure, liver disease, mental/mood changes, seizures, stomach problems (e. g. ulcers, obstruction), an overactive thyroid gland, difficulty urinating (e. g. due to an enlarged prostate gland).

Benadryl is in the FDA pregnancy category B. This means that it is not expected to be harmful to an unborn baby. Do not take Benadryl without first talking to your doctor if you are pregnant. Infants are especially sensitive to the effects of antihistamines, and side effects could occur in a breast-feeding baby. Do not take Benadryl without first talking to your doctor if you are nursing a baby.

If you are over 60 years of age, you may be more likely to experience side effects from Benadryl. You may require a lower dose of Benadryl.

Stop taking Benadryl and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives).

Other, less serious side effects may be more likely to occur. Continue to take Benadryl and talk to your doctor if you experience:

sleepiness, fatigue, or dizziness;

headache;

dry mouth; or

difficulty urinating or an enlarged prostate.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

When using this product:

marked drowsiness may occur

avoid alcoholic drinks

alcohol, sedatives, and tranquilizers may increase drowsiness

excitability may occur, especially in children

be careful when driving a motor vehicle or operating machinery

Bexolo, Bexolo

Betaxolol

Click for further information on drug naming conventions and International Nonproprietary Names .

Important Notice: The Drugs. com international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

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Anacin (Aspirin, Sifenol

Product Description

Anacin prescribed for treatment of pain, with different nature of appearance (muscle aches, headache, toothache, arthritis and rheumatism, menstrual cramps, pain and fever of common cold) and for reducing of the tendency of blood clots. This medication is a combination of stimulant and salicylate. His mechanism of working is the the following: it blocks several different chemical processes within the body that cause pain, inflammation and fever.

Consult with your doctor about dosage. Anacin may cause stomach upset, so better take it with food to reduce stomach irritation. Use the medicine with a full glass of water and avoid a recumbent position during next 30 minutes.

Before to start treatment with Anacin consult with your doctor or pharmacist if you have: allergy to food, medicines, or other substances, asthma, bleeding or clotting problems, kidney or liver problems, stomach and intestinal problems, growths in the nose, heart problems, upset stomach, heartburn, stomach pain, hives, flu, chickenpox; anxiety, trouble sleeping or heart problems; if you have a plan to become pregnant, or you are pregnant, or you're breastfeeding; if you are taking any prescribed and not prescribed medicine, herbal products, or dietary supplement; vitamin K deficiency; alcoholism or if you consume 3 or more alcohol drinks per day. Children with a stroke, a weaken blood vessel or bleeding in the brain, Kawasaki syndrome or rheumatic disease shouldn't use Anacin.

Patients with an allergy to any ingredient of Anacin, or who has a severe allergic reaction such as rush, hives, breathing difficulties, dizziness to aspirin, tartrazine or non-steroidal anti-inflammatory drug (NSAID), children or teenagers with flu or chickenpox, patients with bleeding problems such as hemophilia, Von Willebrand disease, low blood platelets, or active severe bleeding and patients, who are taking anticoagulants or methotrexate - shouldn't use Anacin.

Possible side effects

Possible side effects are the following: dizziness, irritability, nausea, nervousness, upset stomach. The severe side effects include allergic reactions such as rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; confusion; diarrhea; drowsiness; severe or persistent dizziness hearing loss; ringing in the ears; severe or persistent stomach pain or heartburn; black or bloody stools; shakiness; trouble sleeping; vomiting. In case if you think that you feel some symptoms of side effects you should call for medical help immediately.

You must consult with your doctor about interaction between Anacin and the following drugs: angiotensin-converting enzyme (ACE) inhibitors (enalapril), probenecid, or sulfinpyrazone because their effectiveness may be decreased by Anacin; carbonic anhydrase inhibitors (acetazolamide) because they may decrease Anacin's effectiveness; insulin or oral anti-diabetics because the risk of their side effects, including low blood sugar may be increased by Anacin; anticoagulants ( heparin, warfarin), clopidogrel, or NSAIDs (ibuprofen, celecoxib) because the risk of their side effects, including risk of bleeding, may be increased by Anacin; quinolones (ciprofloxacin).

Never take more than prescribed dose, even if you missed the one. Try to take it as soon as possible. Or, if it's too late, just skip it and take your usually dose next day in the same regularly time.

In case if you think that you could be overdosed by Anacin you should call for medical help immediately. Symptoms of Anacin overdose are following: agitation; anxiety; confusion; fever; hearing loss; lethargy; lightheadedness, especially upon standing; muscle twitching; nausea; rapid breathing; rapid or irregular heartbeat; ringing in the ears; seizures; shortness of breath; stomach pain; trouble sleeping; vomiting. If you think that you overdosed Anacin, seek medical attention at once.

Store at room temperature between 68-77 F (20-25 C), in a dark and dry place. Save it from children and pets. Watch the expiration date!

The information presented at the site has a general character. Note please this information cannot be used for self-treatment and self diagnosis. You should consult with your doctor or health care adviser regarding any specific instructions of your condition. The information is reliable, but we concede it could contain mistakes. We are not responsible for any direct, indirect, special or other damage caused by use of this information on the site and also for consequences of self-treatment.

Customers Who Bought This Product Also Bought:

Galepsi, Galepsi

Neurontin is used for treating seizures associated with epilepsy. Neurontin is an anticonvulsant.

Use Neurontin as directed by your doctor.

Take Neurontin by mouth with or without food.

Do not take an antacid containing aluminum or magnesium within 2 hours before you take Neurontin.

If you are taking half of a scored tablet as your dose, take the other half of that tablet as your next dose. Throw away any half-tablets not used within several days of breaking a scored tablet.

Do not suddenly stop taking Neurontin. You may have an increased risk of side effects (eg, seizures). If you need to stop Neurontin or add a new medicine, your doctor will gradually lower your dose.

If you miss a dose of Neurontin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Neurontin.

Store Neurontin at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Neurontin out of the reach of children and away from pets.

Active Ingredient: Gabapentin.

Do NOT use Neurontin if:

you are allergic to any ingredient in Neurontin.

Some medical conditions may interact with Neurontin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have kidney problems and are on dialysis

if you have a history of mental or mood problems (eg, depression), or suicidal thoughts or actions.

Some medicines may interact with Neurontin. Tell your health care provider if you are taking any medicines, especially any of the following:

Morphine because it may increase the risk of Neurontin's side effects, including drowsiness.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Neurontin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Neurontin may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Neurontin with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Patients who take Neurontin may be at increased risk for suicidal thoughts or actions. The risk may be greater in patients who have had suicidal thoughts or actions in the past. Watch patients who take Neurontin closely. Contact the doctor at once if new, worsened, or sudden symptoms such as depressed mood; anxious, restless, or irritable behavior; panic attacks; or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur.

Diabetes patients - Neurontin may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

Neurontin may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Neurontin.

Lab tests, including liver function, kidney function, and complete blood cell counts, may be performed while you use Neurontin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Neurontin with caution in the elderly; they may be more sensitive to its effects.

Neurontin may cause emotional or behavioral side effects in children 3 to 12 years. If the following side effects occur, notify your doctor immediately: emotional "swings", hostile or aggressive behavior, problems concentrating, decreased performance at school, an increase in restlessness or hyperactivity.

Neurontin should be used with extreme caution in children younger 3 years; safety and effectiveness in these children have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Neurontin while you are pregnant. Neurontin is found in breast milk. If you are or will be breast-feeding while you use Neurontin, check with your doctor. Discuss any possible risks to your baby.

If you stop taking Neurontin suddenly, you may have withdrawal symptoms. These may include dizziness, drowsiness, clumsiness, hostility, hyperactivity, mood swings, nausea, tiredness, or vomiting.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Back pain; changes in vision (double or blurred vision); clumsiness; constipation; diarrhea; dizziness; drowsiness; dry mouth; nausea; stomach upset; tiredness; vomiting; weight gain.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal thoughts; back and forth eye movements; behavioral problems; change in school performance; chest pain; confusion; fainting; fast, slow, or irregular heartbeat; fever, chills, or sore throat; hyperactivity; loss of coordination; memory loss; new or worsening mental or mood changes (eg, depression, agitation, anxiety, panic attacks, aggressiveness, impulsiveness, irritability, hostility, exaggerated feeling of well-being, restlessness, inability to sit still); new or worsening seizures; numbness of an arm or leg; one-sided weakness; severe headache or dizziness; shortness of breath; speech changes; suicidal thoughts or actions; swelling of the hands, legs, or feet; tremor; trouble concentrating; twitching.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Neurontin is used for treating seizures associated with epilepsy. Neurontin is an anticonvulsant.

Use Neurontin as directed by your doctor.

Take Neurontin by mouth with or without food.

Do not take an antacid containing aluminum or magnesium within 2 hours before you take Neurontin.

If you are taking half of a scored tablet as your dose, take the other half of that tablet as your next dose. Throw away any half-tablets not used within several days of breaking a scored tablet.

Do not suddenly stop taking Neurontin. You may have an increased risk of side effects (eg, seizures). If you need to stop Neurontin or add a new medicine, your doctor will gradually lower your dose.

If you miss a dose of Neurontin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Neurontin.

Store Neurontin at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Neurontin out of the reach of children and away from pets.

Active Ingredient: Gabapentin.

Do NOT use Neurontin if:

you are allergic to any ingredient in Neurontin.

Some medical conditions may interact with Neurontin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have kidney problems and are on dialysis

if you have a history of mental or mood problems (eg, depression), or suicidal thoughts or actions.

Some medicines may interact with Neurontin. Tell your health care provider if you are taking any medicines, especially any of the following:

Morphine because it may increase the risk of Neurontin's side effects, including drowsiness.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Neurontin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Neurontin may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Neurontin with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Patients who take Neurontin may be at increased risk for suicidal thoughts or actions. The risk may be greater in patients who have had suicidal thoughts or actions in the past. Watch patients who take Neurontin closely. Contact the doctor at once if new, worsened, or sudden symptoms such as depressed mood; anxious, restless, or irritable behavior; panic attacks; or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur.

Diabetes patients - Neurontin may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

Neurontin may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Neurontin.

Lab tests, including liver function, kidney function, and complete blood cell counts, may be performed while you use Neurontin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Neurontin with caution in the elderly; they may be more sensitive to its effects.

Neurontin may cause emotional or behavioral side effects in children 3 to 12 years. If the following side effects occur, notify your doctor immediately: emotional "swings", hostile or aggressive behavior, problems concentrating, decreased performance at school, an increase in restlessness or hyperactivity.

Neurontin should be used with extreme caution in children younger 3 years; safety and effectiveness in these children have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Neurontin while you are pregnant. Neurontin is found in breast milk. If you are or will be breast-feeding while you use Neurontin, check with your doctor. Discuss any possible risks to your baby.

If you stop taking Neurontin suddenly, you may have withdrawal symptoms. These may include dizziness, drowsiness, clumsiness, hostility, hyperactivity, mood swings, nausea, tiredness, or vomiting.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Back pain; changes in vision (double or blurred vision); clumsiness; constipation; diarrhea; dizziness; drowsiness; dry mouth; nausea; stomach upset; tiredness; vomiting; weight gain.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal thoughts; back and forth eye movements; behavioral problems; change in school performance; chest pain; confusion; fainting; fast, slow, or irregular heartbeat; fever, chills, or sore throat; hyperactivity; loss of coordination; memory loss; new or worsening mental or mood changes (eg, depression, agitation, anxiety, panic attacks, aggressiveness, impulsiveness, irritability, hostility, exaggerated feeling of well-being, restlessness, inability to sit still); new or worsening seizures; numbness of an arm or leg; one-sided weakness; severe headache or dizziness; shortness of breath; speech changes; suicidal thoughts or actions; swelling of the hands, legs, or feet; tremor; trouble concentrating; twitching.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Biphasil Tablets, Biphasil

PROPRIETARY NAME (and dosage form)

COMPOSITION: The eleven white tablets of BIPHASIL* contain 50 µg of levonorgestrel and 50 µg of ethinyl oestradiol . The ten orange tablets contain 125 µg of levonorgestrel and 50 µg of ethinyl oestradiol. The seven red tablets are inert. The orange tablets contain TARTRAZINE.

PHARMACOLOGICAL CLASSIFICATION: Category A, 18.8 Ovulation controlling agents

PHARMACOLOGICAL ACTION: Oral contraceptives containing a progestogen and an oestrogen act by a multiplicity of mechanisms including inhibition of ovulation.

INDICATIONS: BIPHASIL* is indicated for fertility control in women and for the control of certain menstrual irregularities.

CONTRAINDICATIONS: There are no known contra-indications for normal healthy women. Oral contraceptives are contra-indicated in patients with recurrent cholestatic jaundice, or markedly impaired liver-function, hormone-dependent neoplasms, previous thromboembolic disorders, severe migraine or cerebrovascular insufficiency and undiagnosed vaginal bleeding. Medication should be discontinued immediately if migraine becomes focal, or if there is a loss of vision, or if there is an onset of unexplained chest pain. Relative contra-indications include a history of diabetes mellitus, epilepsy, asthma, hypertension, depression, porphyria or states in which fluid retention occur. Combined oral contraceptives should be avoided in pregnancy and in patients who are breast feeding.

WARNINGS: There are some effects of the pill that are very important. Even though they rarely occur, you should be aware of them. Stop taking tablets and see your doctor immediately if you have persistent vaginal bleeding or discomfort, constant leg or chest pain, breathing difficulties, severe headache or vomiting, dizziness or fainting, difficulty seeing or talking, numb or weak feeling in an arm or leg, it you become very sad or irritable, if you cough up blood or have other unusual symptoms. If you omit 1 or more pills and miss a menstrual period, see your doctor. Discontinue BIPHASIL* until he says you can resume. If while on BIPHASIL*, you develop an illness with vomiting and diarrhoea that lasts over 24 hours, your protection may be reduced. In such a case, see your doctor. BIPHASIL* tablets are to be used only on the advice, or on the recommendation of your doctor, who will give you more complete information on the use of BIPHASIL* and will advise you about possible contra - indications (conditions in which you should not take this type of medication).

The orange tablets of this product contain F D and C Yellow No 5 (tartrazine), which may cause allergic-type reactions (including bronchial asthma) in certain susceptible individuals. Although the overall incidence of tartrazine-sensitivity in the general population is currently thought to be low, it is frequently seen in patients who also have aspirin-sensitivity.

DOSAGE AND DIRECTIONS FOR USE: First Cycle: New patients should begin by taking the first tablet on the first day of the menstrual cycle (i. e. the first day of bleeding.) The first tablet should be selected from those in the black circles in the shaded sector of the pack. The first tablet to be taken is that in the black circle marked with the appropriate day of the week. Thereafter, one tablet is taken daily, following the arrows marked on the package until all 28 tablets are finished. Note: New patients with a history of short menstrual cycles, i. e. less than 25 days, are advised to consult their doctor concerning alternative protection for the first 14 days of use in the first cycle only. After 28 tablets have been taken, the first cycle of BIPHASIL* will have been completed. Menstruation should occur two to four days after taking the last orange tablet.

Subsequent cycles: A new pack should be started the day after completion of the previous pack by taking the tablet in the black circle in the shaded sector of the new pack indicated with the appropriate day of the week. There must be no interruption of treatment, i. e. the new pack is started immediately after completion of the previous pack and each new pack is started with the same tablet in the black circle in the shaded sector of the pack. This method should continue for as long as contraception is desired. Each cycle will begin on the same day of the week.

SIDE EFFECTS AND SPECIAL PRECAUTIONS:

The incidence of diseases of the circulatory system in women using combined oral contraceptives is significantly greater than those of controls, and the mortality is slightly increased. Coronary thrombosis, cerebrovascular accidents and venous thrombosis, are more likely to occur in women aged 35 years or over, particularly if they have used the contraceptive for longer than five years, if they smoke, if they are obese or if they are hypertensive. Additional risk factors are diabetes, hypercholesterolaemia and familial hyperlipoproteinaemia. However, the risk of mortality due to oral contraceptives in women under 35 who are in the high-risk group is in general far less than the risk of mortality due to pregnancy.

Hypertension may occur in association with the use of oral contraceptives. Regular blood pressure checks, including a pretreatment level, are advisable.

Prolonged amenorrhoea following the use of oral contraceptives may occur. The incidence is in the order of 1% of users. Caution is advised where oligomenorrhoea or amenorrhoea have occurred in the past.

Mood changes, mass gain, skin pigmentation, vaginal candidiasis, gall bladder disease, gastrointestinal irritation and fluid retention may occur.

Case reports have been published of benign hepatic tumours in women on oral contraceptives for a prolonged time, but a causal relationship has not been established. The preparation should be discontinued if persistent upper abdominal pain develops.

Interactions with other medicines and efficacy: The efficacy of the contraceptive pill may be decreased when it is administered concomitantly with other medicines such as the anti-epileptic agents, rifampicin, phenylbutazone and ampicillin. With vomiting and diarrhoea, the absorption of oral contraceptives may be diminished and women should be advised to use additional methods of contraception at the time of such disorders.

Effects on laboratory tests: Oral contraceptives may interfere with some laboratory estimations, in particular hormones, glucose tolerance, thyroid function, blood coagulation, serum triglycerides and liver function tests.

Surgery is more likely to be associated with an increased incidence of thrombotic side effects. Adequate precaution should be taken.

Under no circumstances should the oral contraceptive tablet be stopped without having adopted a satisfactory alternative method of contraception.

Changes the patient may expect: The patient will probably have a menstrual period two to four days after taking the last active tablet in each package. In some women the amount of menstrual flow may change slightly after taking BIPHASIL*; however, this happens infrequently and should be of no major concern. Light intermenstrual bleeding might occasionally occur while taking BIPHASIL*; however, if this happens, the patient should continue taking her tablets as usual. Such light bleeding will usually disappear by itself. However, if heavier bleeding occurs and persists, the patient should consult her doctor. If the patient should miss one period completely, she should consult her doctor.

Cautions: Omitted Tablets: BIPHASIL* is designed to provide very small amounts of the substances that protect you from pregnancy. It will do this as long as you follow the schedule carefully. However, should you forget to take one or more pills, your body may not have enough of these substances left to prevent pregnancy. In such cases, use an additional birth-control method (other than oral contraceptive tablets). If you miss taking one tablet, take it the next morning or as soon as possible, then take the next tablet at the usual time and continue the course as before. Remember to use an additional contraceptive method until you finish the package. Suppose you forget two tablets in a row. Take the two missed pills when you remember, and the pill for that day at the regular time. in this case you take 3 pills on the day you remember. Continue your schedule until the package is finished. An additional contraceptive method is necessary until you finish the package. If you forget 3 or more tablets in a row, do NOT take them when you remember and do NOT finish the package. Wait 4 more days. This makes one week without tablets. Then begin a new package on DAY 8 even if you are still bleeding. During the 7 days without tablets and until you have taken a tablet daily for 7 days from the new BIPHASIL* package use an additional birth-control method. If you omit any of the pills in a package and do not menstruate when you expect to, see your doctor or health advisor. Do not take any more tablets until the doctor says you can.

KNOWN SYMPTOMS OF OVERDOSAGE AND PARTICULARS OF ITS TREATMENT: The treatment of overdosage is symptomatic and supportive.

CONDITIONS OF REGISTRATION: Advertising to the professions only.

IDENTIFICATION: The BIPHASIL* package contains 28 tablets (11 white, 10 orange and 7 red).

PRESENTATION: Each course of BIPHASIL* comprises 11 white, 10 orange and 7 red tablets packed in a blister type package.

STORAGE INSTRUCTIONS: Store in a cool place (below 25°C), dry place. Keep out of reach of children.

REGISTRATION NUMBER: H/18.8/10

NAME AND BUSINESS ADDRESS OF THE APPLICANT: AKROMED PRODUCTS (PTY) LTD. (Co. Reg. no. 05/13586/07) Electron Avenue, ISANDO 1600 * Registered Trademark * Under licence from WYETH-AYERST LABORATORIES, U. S.A.

DATE OF PUBLICATION OF THIS PACKAGE INSERT:

Buy Kohakusanin - Online Without Prescriptions, Kohakusanin

Prednisolone (Kohakusanin)

Prednisolone is used for treating allergies, arthritis, breathing problems (eg, asthma), certain blood disorders, collagen diseases (eg, lupus), certain eye diseases (eg, keratitis), cancer (eg, leukemia), endocrine problems (eg, adrenocortical insufficiency), intestinal problems (eg, ulcerative colitis), swelling due to certain conditions, or skin conditions (eg, psoriasis). Prednisolone is a corticosteroid. It works by modifying the body's immune response to various conditions and decreasing inflammation.

Use Prednisolone as directed by your doctor.

Take Prednisolone by mouth with food.

If you miss a dose of Prednisolone, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Prednisolone.

Store Prednisolone at room temperature, between 68 and 77 degrees F (20 and 25 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Prednisolone out of the reach of children and away from pets.

Do NOT use Prednisolone if:

you are allergic to any ingredient in Prednisolone

you have a systemic fungal infection, a certain type of malaria, inflammation of the optic nerve, or herpes infection of the eye

you are scheduled to have a live or attenuated live vaccination (eg, smallpox)

you are taking mifepristone.

Contact your doctor right away if any of these apply to you.

Some medical conditions may interact with Prednisolone. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of heart problems (eg, congestive heart failure), heart attack, high blood pressure, kidney problems, liver problems, diabetes, seizures, an underactive thyroid, adrenal gland problems, fluid retention (eg, swelling of the hands, ankles, or feet), or any mental or mood problems

if you have or have recently had a fungal, bacterial, viral, or other type of infection; herpes infection of the eye; chickenpox; measles; or shingles

if you have HIV infection or tuberculosis (TB) infection, or if you have had ever had a positive TB skin test

if you have any stomach problems (eg, ulcers), intestinal problems (eg, blockage, perforation, or infection; unexplained diarrhea; diverticulitis; ulcerative colitis), recent intestinal surgery, or inflammation of the esophagus

if you have weak bones (eg, osteoporosis) or muscle problems (eg, myasthenia gravis)

if you have had a recent vaccination (eg, smallpox).

Some medicines may interact with Prednisolone. Tell your health care provider if you are taking any other medicines, especially any of the following:

Clarithromycin, cyclosporine, estrogens (eg, estradiol), oral contraceptives (eg, birth control pills), or ketoconazole because they may increase the risk of Prednisolone's side effects

Barbiturates (eg, phenobarbital), carbamazepine, ephedrine, hydantoins (eg, phenytoin), or rifampin because they may decrease Prednisolone's effectiveness

Anticholinesterases (eg, pyridostigmine), aspirin, diuretics (eg, hydrochlorothiazide, furosemide), methotrexate, mifepristone, quinolone antibiotics (eg, ciprofloxacin), ritodrine, or live or attenuated live vaccines because the risk of their side effects may be increased by Prednisolone

Anticoagulants (eg, warfarin), hydantoins (eg, phenytoin), or killed or inactivated vaccines because their effectiveness may be decreased by Prednisolone.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Prednisolone may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Avoid alcohol while you are using Prednisolone.

Prednisolone may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.

If you have not had chickenpox, shingles, or measles, avoid contact with anyone who does.

If you are taking Prednisolone regularly over a long period of time, carry an ID card at all times that says you take Prednisolone.

Do not receive a live vaccine (eg, measles, mumps, smallpox) while you are taking Prednisolone. Talk with your doctor before you receive any vaccine.

Tell your doctor or dentist that you take Prednisolone before you receive any medical or dental care, emergency care, or surgery.

Diabetes patients - Prednisolone may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

Lab tests, including adrenal function tests, may be performed while you use Prednisolone. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Caution is advised when using Prednisolone in children; they may be more sensitive to its effects.

Corticosteroids may affect growth rate in children and teenagers in some cases. They may need regular growth checks while they take Prednisolone.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Prednisolone while you are pregnant. Prednisolone is found in breast milk. If you are or will be breast-feeding while you use Prednisolone, check with your doctor. Discuss any possible risks to your baby.

If you are on long-term or high dosage therapy and you suddenly stop taking Prednisolone, you may have withdrawal symptoms, including fever, vomiting, appetite loss, diarrhea, nausea, dizziness, weight loss, weakness, general body discomfort, joint or muscle pain.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Acne; clumsiness; dizziness; facial flushing; feeling of a whirling motion; general body discomfort; headache; increased appetite; increased sweating; nausea; nervousness; sleeplessness; upset stomach.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; changes in body fat; changes in menstrual period; changes in skin color; chest pain; easy bruising or bleeding; increased hunger, thirst, or urination; mental or mood changes (eg, depression); muscle pain, weakness, or wasting; seizures; severe nausea or vomiting; shortness of breath; signs of infection (eg, fever, chills, persistent sore throat); sudden severe dizziness or headache; swelling of ankles, feet, or hands; tendon or bone pain; thinning of skin; unusual skin sensation; unusual weight gain; vision changes or other eye problems; vomit that looks like coffee grounds.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Customers who bought this product also bought

Prednisolone (Kohakusanin)

Prednisolone is used for treating allergies, arthritis, breathing problems (eg, asthma), certain blood disorders, collagen diseases (eg, lupus), certain eye diseases (eg, keratitis), cancer (eg, leukemia), endocrine problems (eg, adrenocortical insufficiency), intestinal problems (eg, ulcerative colitis), swelling due to certain conditions, or skin conditions (eg, psoriasis). Prednisolone is a corticosteroid. It works by modifying the body's immune response to various conditions and decreasing inflammation.

Use Prednisolone as directed by your doctor.

Take Prednisolone by mouth with food.

If you miss a dose of Prednisolone, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Prednisolone.

Store Prednisolone at room temperature, between 68 and 77 degrees F (20 and 25 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Prednisolone out of the reach of children and away from pets.

Do NOT use Prednisolone if:

you are allergic to any ingredient in Prednisolone

you have a systemic fungal infection, a certain type of malaria, inflammation of the optic nerve, or herpes infection of the eye

you are scheduled to have a live or attenuated live vaccination (eg, smallpox)

you are taking mifepristone.

Contact your doctor right away if any of these apply to you.

Some medical conditions may interact with Prednisolone. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of heart problems (eg, congestive heart failure), heart attack, high blood pressure, kidney problems, liver problems, diabetes, seizures, an underactive thyroid, adrenal gland problems, fluid retention (eg, swelling of the hands, ankles, or feet), or any mental or mood problems

if you have or have recently had a fungal, bacterial, viral, or other type of infection; herpes infection of the eye; chickenpox; measles; or shingles

if you have HIV infection or tuberculosis (TB) infection, or if you have had ever had a positive TB skin test

if you have any stomach problems (eg, ulcers), intestinal problems (eg, blockage, perforation, or infection; unexplained diarrhea; diverticulitis; ulcerative colitis), recent intestinal surgery, or inflammation of the esophagus

if you have weak bones (eg, osteoporosis) or muscle problems (eg, myasthenia gravis)

if you have had a recent vaccination (eg, smallpox).

Some medicines may interact with Prednisolone. Tell your health care provider if you are taking any other medicines, especially any of the following:

Clarithromycin, cyclosporine, estrogens (eg, estradiol), oral contraceptives (eg, birth control pills), or ketoconazole because they may increase the risk of Prednisolone's side effects

Barbiturates (eg, phenobarbital), carbamazepine, ephedrine, hydantoins (eg, phenytoin), or rifampin because they may decrease Prednisolone's effectiveness

Anticholinesterases (eg, pyridostigmine), aspirin, diuretics (eg, hydrochlorothiazide, furosemide), methotrexate, mifepristone, quinolone antibiotics (eg, ciprofloxacin), ritodrine, or live or attenuated live vaccines because the risk of their side effects may be increased by Prednisolone

Anticoagulants (eg, warfarin), hydantoins (eg, phenytoin), or killed or inactivated vaccines because their effectiveness may be decreased by Prednisolone.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Prednisolone may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Avoid alcohol while you are using Prednisolone.

Prednisolone may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.

If you have not had chickenpox, shingles, or measles, avoid contact with anyone who does.

If you are taking Prednisolone regularly over a long period of time, carry an ID card at all times that says you take Prednisolone.

Do not receive a live vaccine (eg, measles, mumps, smallpox) while you are taking Prednisolone. Talk with your doctor before you receive any vaccine.

Tell your doctor or dentist that you take Prednisolone before you receive any medical or dental care, emergency care, or surgery.

Diabetes patients - Prednisolone may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

Lab tests, including adrenal function tests, may be performed while you use Prednisolone. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Caution is advised when using Prednisolone in children; they may be more sensitive to its effects.

Corticosteroids may affect growth rate in children and teenagers in some cases. They may need regular growth checks while they take Prednisolone.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Prednisolone while you are pregnant. Prednisolone is found in breast milk. If you are or will be breast-feeding while you use Prednisolone, check with your doctor. Discuss any possible risks to your baby.

If you are on long-term or high dosage therapy and you suddenly stop taking Prednisolone, you may have withdrawal symptoms, including fever, vomiting, appetite loss, diarrhea, nausea, dizziness, weight loss, weakness, general body discomfort, joint or muscle pain.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Acne; clumsiness; dizziness; facial flushing; feeling of a whirling motion; general body discomfort; headache; increased appetite; increased sweating; nausea; nervousness; sleeplessness; upset stomach.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; changes in body fat; changes in menstrual period; changes in skin color; chest pain; easy bruising or bleeding; increased hunger, thirst, or urination; mental or mood changes (eg, depression); muscle pain, weakness, or wasting; seizures; severe nausea or vomiting; shortness of breath; signs of infection (eg, fever, chills, persistent sore throat); sudden severe dizziness or headache; swelling of ankles, feet, or hands; tendon or bone pain; thinning of skin; unusual skin sensation; unusual weight gain; vision changes or other eye problems; vomit that looks like coffee grounds.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Customers who bought this product also bought

Prednisolone (Kohakusanin)

Prednisolone is used for treating allergies, arthritis, breathing problems (eg, asthma), certain blood disorders, collagen diseases (eg, lupus), certain eye diseases (eg, keratitis), cancer (eg, leukemia), endocrine problems (eg, adrenocortical insufficiency), intestinal problems (eg, ulcerative colitis), swelling due to certain conditions, or skin conditions (eg, psoriasis). Prednisolone is a corticosteroid. It works by modifying the body's immune response to various conditions and decreasing inflammation.

Use Prednisolone as directed by your doctor.

Take Prednisolone by mouth with food.

If you miss a dose of Prednisolone, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Prednisolone.

Store Prednisolone at room temperature, between 68 and 77 degrees F (20 and 25 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Prednisolone out of the reach of children and away from pets.

Do NOT use Prednisolone if:

you are allergic to any ingredient in Prednisolone

you have a systemic fungal infection, a certain type of malaria, inflammation of the optic nerve, or herpes infection of the eye

you are scheduled to have a live or attenuated live vaccination (eg, smallpox)

you are taking mifepristone.

Contact your doctor right away if any of these apply to you.

Some medical conditions may interact with Prednisolone. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of heart problems (eg, congestive heart failure), heart attack, high blood pressure, kidney problems, liver problems, diabetes, seizures, an underactive thyroid, adrenal gland problems, fluid retention (eg, swelling of the hands, ankles, or feet), or any mental or mood problems

if you have or have recently had a fungal, bacterial, viral, or other type of infection; herpes infection of the eye; chickenpox; measles; or shingles

if you have HIV infection or tuberculosis (TB) infection, or if you have had ever had a positive TB skin test

if you have any stomach problems (eg, ulcers), intestinal problems (eg, blockage, perforation, or infection; unexplained diarrhea; diverticulitis; ulcerative colitis), recent intestinal surgery, or inflammation of the esophagus

if you have weak bones (eg, osteoporosis) or muscle problems (eg, myasthenia gravis)

if you have had a recent vaccination (eg, smallpox).

Some medicines may interact with Prednisolone. Tell your health care provider if you are taking any other medicines, especially any of the following:

Clarithromycin, cyclosporine, estrogens (eg, estradiol), oral contraceptives (eg, birth control pills), or ketoconazole because they may increase the risk of Prednisolone's side effects

Barbiturates (eg, phenobarbital), carbamazepine, ephedrine, hydantoins (eg, phenytoin), or rifampin because they may decrease Prednisolone's effectiveness

Anticholinesterases (eg, pyridostigmine), aspirin, diuretics (eg, hydrochlorothiazide, furosemide), methotrexate, mifepristone, quinolone antibiotics (eg, ciprofloxacin), ritodrine, or live or attenuated live vaccines because the risk of their side effects may be increased by Prednisolone

Anticoagulants (eg, warfarin), hydantoins (eg, phenytoin), or killed or inactivated vaccines because their effectiveness may be decreased by Prednisolone.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Prednisolone may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Avoid alcohol while you are using Prednisolone.

Prednisolone may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.

If you have not had chickenpox, shingles, or measles, avoid contact with anyone who does.

If you are taking Prednisolone regularly over a long period of time, carry an ID card at all times that says you take Prednisolone.

Do not receive a live vaccine (eg, measles, mumps, smallpox) while you are taking Prednisolone. Talk with your doctor before you receive any vaccine.

Tell your doctor or dentist that you take Prednisolone before you receive any medical or dental care, emergency care, or surgery.

Diabetes patients - Prednisolone may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

Lab tests, including adrenal function tests, may be performed while you use Prednisolone. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Caution is advised when using Prednisolone in children; they may be more sensitive to its effects.

Corticosteroids may affect growth rate in children and teenagers in some cases. They may need regular growth checks while they take Prednisolone.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Prednisolone while you are pregnant. Prednisolone is found in breast milk. If you are or will be breast-feeding while you use Prednisolone, check with your doctor. Discuss any possible risks to your baby.

If you are on long-term or high dosage therapy and you suddenly stop taking Prednisolone, you may have withdrawal symptoms, including fever, vomiting, appetite loss, diarrhea, nausea, dizziness, weight loss, weakness, general body discomfort, joint or muscle pain.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Acne; clumsiness; dizziness; facial flushing; feeling of a whirling motion; general body discomfort; headache; increased appetite; increased sweating; nausea; nervousness; sleeplessness; upset stomach.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; changes in body fat; changes in menstrual period; changes in skin color; chest pain; easy bruising or bleeding; increased hunger, thirst, or urination; mental or mood changes (eg, depression); muscle pain, weakness, or wasting; seizures; severe nausea or vomiting; shortness of breath; signs of infection (eg, fever, chills, persistent sore throat); sudden severe dizziness or headache; swelling of ankles, feet, or hands; tendon or bone pain; thinning of skin; unusual skin sensation; unusual weight gain; vision changes or other eye problems; vomit that looks like coffee grounds.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Teroxina

Cada CÁPSULA de 500 mg contiene: Cefadroxilo monohidratado equivalente a. 500 mg de cefadroxilo base Excipiente, c. b.p. 1 cápsula.

Cada CÁPSULA de 250 mg contiene: Cefadroxilo monohidratado equivalente a. 250 mg de cefadroxilo base Excipiente, c. b.p. 1 cápsula.

Cada 5 ml de SUSPENSIÓN para 500 mg ­contienen: Cefadroxilo monohidratado equivalente a. 500 mg de cefadroxilo base Vehículo, c. b.p. 5 ml.

Cada 5 ml de SUSPENSIÓN para 250 mg ­contienen: Cefadroxilo monohidratado equivalente a. 250 mg de cefadroxilo base Vehículo, c. b.p. 5 ml.

TEROXINA* está indicado para el tratamiento de pacientes con infecciones causadas por microorganismos sensibles, en las siguientes enfermedades:

Infecciones en el tracto genitourinario provocadas por E. coli, P. mirabilis y especies de Klebsiella.

Infecciones de la piel y tejidos blandos provocadas por estafilococos y estreptococos.

Se utiliza solo o en combinación para el tratamiento de infec­ciones del tracto respiratorio alto y bajo, infecciones de los huesos y articulaciones (osteomielitis y artritis séptica).

Únicamente la penicilina por vía intramuscular ha demostrado ser efectiva en la profilaxis de la fiebre reumática. TEROXINA* es efectivo en la erradicación del estreptococo de la orofaringe, sin embargo; no disponemos de información sobre la eficacia de TEROXINA* en la pro­fila­xis de la fiebre reumática.

Nota: Antes y durante la terapia deberán realizarse cultivos para pruebas de sensibilidad de los microorganismos. En caso de ser necesario, deben practicarse pruebas de función renal, y realizarse procedimientos quirúrgicos cuando estén indicados.

FARMACOCIN?TICA Y FARMACODINAMIA

Farmacología clínica: TEROXINA* (cefadroxilo) es absorbido rápidamente luego de su administración oral. Después de administrar dosis únicas de 500 y 1,000 mg, la concentración máxima promedio en suero fue de aproximadamente 16 y 28 µg/ml, respectivamente, 12 horas posteriores a la administración, aun se encontraron niveles cuantificables de cefadroxilo. Más de 90% del fármaco es excretado sin cambios en la orina luego de 24 horas.

Las concentraciones máximas en orina son de aproxima­damente 1,800 µg/ml después de una dosis oral única de 500 mg. La vida media de eliminación es de aproximadamente 2 horas.

Un incremento en la dosis generalmente provoca un aumento proporcional en la concentración urinaria de ­TEROXINA*.

La concentración antibiótica en la orina, posterior a la ad­ministración de 1 g, produce niveles superiores a las CMIs (Concentraciones Mínimas Inhibitorias) para la mayoría de la flora patógena susceptible en orina, durante 20 a 22 horas.

Microbiología: Las pruebas in vitro demostraron que las cefalosporinas son bactericidas debido a que inhi­ben la síntesis de la pared celular. Se ha demostrado que TERO­XINA* tiene actividad contra los siguientes organismos, tanto in vitro como en infecciones clínicas: estreptococo betahemolítico.

Estafilococo , incluyendo coagulasa-positivo, ­coagulasa-negativo y cepas productoras de betalactamasa.

Streptococcus (Diplococcus) pneumonie.

Moraxella (Branhamella) catarrhalis.

Otras cepas de microorganismos gramnegativos sensibles son: H. influenzae, Salmonella spp y ­Shigella spp.

Nota: La mayoría de las cepas de Enterococcus faecalis (antiguamente Streptococcus faecalis ) y Enterococcus faecium (antiguamente Streptococcus faecium ) son resistentes al cefadroxilo.

No es activo contra todas las cepas de Enterobacter sp, Morganella morganii (antiguamente Proteus morganii ) y P. vulgaris.

No tiene actividad contra Pseudomonas sp y Acinetobacter calcoaceticus (antes Mima y Herellea sp ).

Pruebas de sensibilidad:

Técnicas de difusión (sensi­dis­cos): Se requieren métodos cuantitativos para medir la zona de inhibición, para estimar con mayor precisión la susceptibilidad al antibió­tico.

Se utiliza un disco para prueba de susceptibilidad para cefalosporinas con interpretaciones correlativas del diámetro de inhibición del disco, con valores de Concentración Mínima Inhibitoria (CMI) de TEROXINA*.

Con este procedimiento, un reporte de laboratorio que indi­que que el organismo es ?susceptible? indica que es probable que el organismo infeccioso responda a la terapia. Un reporte de ?resistente? indica que el organis­mo infeccioso probablemente no responda a la ­terapia.

Un reporte de ?susceptibilidad media? sugiere que el organismo infeccioso será susceptible siempre y cuando la infección esté confinada en un área donde se alcancen las concentraciones adecuadas del antibiótico como, por ejemplo, el tracto urinario.

TEROXINA* (cefadroxilo) está contraindicado en pacientes con alergia conocida al grupo de antibióticos cefalosporínicos.

En pacientes alérgicos a la penicilina, los antibióticos cefalosporínicos deberán administrarse con gran cui­-da­do, ya que existe evidencia clínica y de laboratorio de aler­genicidad parcial cruzada entre cefalosporinas y penicilinas.

Existen, además, antecedentes de pacientes que han reaccionado con alergia a ambos fármacos, incluyendo anafilaxia fatal después de uso parenteral.

Cualquier paciente que ha mostrado alguna forma de alergia a medicamentos, debe recibir el antibiótico con precaución y únicamente cuando sea necesario, sin ex­cepción alguna.

Se han reportado casos de colitis seudomembranosa con el uso de cefalosporinas (y otros antibióticos de amplio espectro). Sin embargo, es importante considerar su diagnóstico en pacientes que desarrollan ­diarrea durante el uso del antibiótico.

El tratamiento con antibióticos de alto espectro, altera la flora normal del colon y puede permitir sobrecrecimiento de clostridia. Los estudios indican que una toxina producida por Clostridium difficile es una de las causas principales de colitis seudomembranosa asociada con el uso de antibióticos. Las resinas de colestiramina y colestipol, han demostrado ligarse a la toxina in vitro.

Los casos leves de colitis pueden mejorar al suspender el tratamiento con cefadroxilo. Los casos moderados a severos, deben ser manejados con líquidos, electrólitos y proteínas cuando sea necesario. Cuando la colitis no cede al suspender la administración del medicamento o cuando es severa, el tratamiento de elección es vancomicina oral para la colitis seudomembranosa producida por C. difficile.

TEROXINA* debe ser usado con precaución en presencia de daño marcado en la función renal.

En pacientes con insuficiencia ­renal confirmada o con sospecha, es necesario, realizar estu­dios de laboratorio apropiados y tener una cuidadosa observación clínica antes y durante la terapia.

En pacientes con depuración de creatinina menor de 50 ml/min/1.73 m 2. la dosis recomendada no debe administrarse a intervalos más frecuentes de c/12 horas.

Para pacientes con una depuración menor de 25 ml/min/1.73 m 2. véase Dosis y vía de administración.

El uso prolongado de TEROXINA* puede provocar el sobrecrecimiento de organismos no susceptibles. Es esencial una cuidadosa observación del paciente; si ocurre una superinfección durante la terapia, deben tomarse las medidas apropiadas.

TEROXINA* debe ser prescrito con precaución en individuos con historia de enfermedad gastrointestinal, particularmente colitis.

Si ocurre una reacción de hipersensibilidad, la administración debe ser suspendida y el paciente debe ser tratado con los agentes adecuados (epinefrina u otras aminas, antihistamínicos o corticosteroides).

Se han reportado, en algunos pacientes, pruebas directas de Coombs positivas durante el tratamiento con cefalos­porinas; asimismo, en pacientes con transfusiones sanguí­neas o en pruebas cruzadas, se han encontrado pruebas de Coombs positivas al determinarse pruebas de antiglo­buli­nas.

La prueba de Coombs puede ser positiva en los neonatos cuyas madres recibieron cefa­losporinas antes del parto, por lo cual debe reconocerse que una prueba de Coombs positiva puede deberse a la administración de cefalosporinas.

RESTRICCIONES DE USO DURANTE EL EMBARAZO Y LA LACTANCIA

Se han realizado estudios de reproducción en ratas y ratones administrando hasta 11 veces la dosis empleada en humanos; dichos estudios han revelado que no existen evidencias de altera­ciones en la fertilidad como daño al feto, debido al uso de TERO­XINA*.

Sin embargo, no existen estudios clínicos adecuados y bien controlados en mujeres embarazadas. Debido a que los estudios de reproducción en animales no siempre predicen la respuesta en humanos, TEROXINA* deberá utilizarse durante el embarazo sólo en caso de ser estrictamente necesario.

TEROXINA* deberá administrarse con precaución en mujeres lactando.

REACCIONES SECUNDARIAS Y ADVERSAS

Los eventos adversos son similares a aquellos observados con otras cefalosporinas.

Gastrointestinales: Durante el tratamiento con TERO­XINA* pueden aparecer síntomas de colitis seudomembranosa. Raramente se han reportado náuseas y vómito. La administración de TEROXINA* con alimentos disminuye las náuseas y no altera la absorción. También puede presentarse diarrea.

Hipersensibilidad: Se han observado reacciones alér­gicas en forma de prurito, urticaria y angioedema; estas reacciones usualmente desaparecen al suspender la administración del medicamento.

Otras reacciones incluyen prurito, moniliasis, vaginitis, elevaciones moderadas de transaminasas en suero y se ha reportado muy raramente síndrome de Stevens-Johnson.

Asimismo, se han observado las siguientes reacciones ad­versas y pruebas de laboratorio alteradas en pa­cien­tes tratados con cefalospo­rinas: anafilaxia, eritema multiforme, necrosis epidérmica tóxica, fiebre, dolor abdominal, super­infección, disfunción renal, nefropatía tóxica, dis­fun­ción hepática incluyendo colestasis, anemia aplásica, anemia hemolítica, hemorragia, tiempo de protrombina prolongado, prueba de Coombs ­positiva, niveles elevados de crea­ti­nina, fosfatasa alcalina elevada, aspartato-ami­no­trans­ferasa (ASAT) elevada, alanino-aminotransfe­rasa (ALAT) elevada, bilirrubina elevada, LDH elevado, eosino­filia, panci­to­penia, neutropenia, agranulocitosis, trombo­citopenia.

Durante la experiencia posmercadeo, se han reportado disfunción hepática y colestasis.

Los reportes de daño hepáticos idiosincrático se han presentado en raras ocasiones. Debido a lo espontáneo de estos reportes, no existe una relación causal entre el daño y el medicamento.

Algunas cefalosporinas se han visto relacionadas con ataques, sobre todo en pacientes con impedimento renal cuando la dosis no fue la adecuada (véase Dosis y vía de administración).

Si ocurren ataques relacionados con la terapia, la administración del fármaco debe ser suspendida, y se puede proporcionar una terapia anticonvulsiva si está indicada clínicamente.

INTERACCIONES MEDICAMENTOSAS Y DE OTRO G?NERO

DOSIS Y V?A DE ADMINISTRACI?N

TEROXINA* es acidorresistente y puede ser administrado oralmente en forma independiente respecto a los alimentos. Administrado con alimentos, puede ayudar a disminuir la acidez gastrointestinal causada ocasionalmente con el tratamiento de cefalosporinas por vía oral.

Infecciones del tracto urinario: Para infecciones del tracto urinario bajo (por ejemplo, cistitis), la dosis usual es de 1 a 2 g al día en dosis única o divididas en dos dosis. Para otras infecciones de vías urinarias, la dosis usual es de 2 g al día en dos dosis.

Infecciones de la piel: Para este tipo de infecciones, la dosis es de 1 g por día en dosis única o dividida en dos dosis.

Faringitis y amigdalitis debidas a estreptococo betahemolítico del grupo A: 1 g al día en dosis única o dividida en dos dosis, por lo menos durante 10 días.

Infecciones respiratorias altas y bajas: Para infecciones leves, la dosis usual es 1 g al día en dos dosis divididas de 500 mg cada una.

Para infecciones moderadas a severas, la dosis recomendada es de 1 a 2 g diariamente en dos dosis divididas (500 mg a 1.0 g cada 12 horas), como se indica. En adultos la dosis inicial es de 1,000 mg de TEROXINA* (cefadroxilo) y la dosis de mantenimiento (basados en el promedio de depuración de creatinina ml/min/1.73 m 2 ), es de 500 mg en el intervalo de horas que aparece en el siguiente cuadro:

Los pacientes con una depuración de creatinina mayor de 50 ml/min pueden ser tratados como si tuvieran función renal normal.

En cinco pacientes adultos anúricos se demostró que un promedio de 63% de la dosis oral de 1 g es eliminada del organismo durante una sesión de hemodiálisis de 6 a 8 horas.

Niños: La dosis recomendada diariamente para niños, es de 25-50 mg/kg/día en dosis divididas (cada 12 horas), como se indica.

En el tratamiento de infecciones por estreptococo betahemolítico, el tratamiento con TEROXINA* debe tener una duración de 10 días. Para el tratamiento de faringitis o amigdalitis por estreptococo ­betahemolítico, tanto en niños como en adultos, TEROXINA* puede ser administrado a dosis única o dividida cada 12 horas. En pacientes con insuficiencia renal, la dosificación deberá ser ajustada de acuerdo con los porcentajes de depuración de creati­ni­na, para evitar acumulación del fármaco.

Método de preparación:

Suspensión oral: Agite o golpee el frasco para remover el polvo. Agregue la cantidad de agua suficiente en dos por­cio­nes. Invierta el frasco y agite bien después de cada porción. Cuando está reconstituida la mezcla de 5 ml, ésta contiene 250 mg o 500 mg de cefadroxilo activo monohidra­tado, dependiendo de la concentración de la fórmula.

MANIFESTACIONES Y MANEJO DE LA SOBREDOSIFICACI?N O INGESTA ACCIDENTAL

Se recomienda vigilancia del paciente a nivel hospitalario, medidas generales, realización de exámenes de laboratorio (biometría hemática, examen general de orina, transaminasas hepáticas, química sanguínea).

En caso necesario, puede colocarse venoclisis y a juicio del médico realizarse hemodiálisis o diálisis peritoneal.

TEROXINA* Cápsulas de 500 mg: caja con 20 ó 16 cápsulas en frasco.

TEROXINA* Cápsulas de 250 mg: caja con 20 cápsulas en frasco.

TEROXINA* Suspensión de 500 mg/5 ml: frasco con 100 ml y dosificador.

TEROXINA* Suspensión de 250 mg/5 ml: frasco con 100 ml y dosificador.

RECOMENDACIONES SOBRE ALMACENAMIENTO

Reconstitución: Leer el instructivo anexo en los frascos. Una vez reconstituido, TEROXINA* se conserva 7 días a temperatura ambiente a no más de 20°C (manténgase en un lugar fresco y seco) o 14 días bajo refrigeración (2-8°C). Agítese bien antes de usarse. Mantenga el frasco bien cerrado.

Deseche la porción restante después de siete días conservado a temperatura ambiente a no más de 30°C o 14 días en refrigeración 2-8°C. No se congele.

Recomendaciones de conservación: Cuando se almacena en un lugar fresco y seco, TEROXINA* Cápsulas y Suspensión en polvo, puede mantenerse estable hasta la fecha de caducidad indicada.

LEYENDAS DE PROTECCI?N

Literatura exclusiva para médicos. No se deje al alcance de los niños. Su venta requiere receta médica. No se administre este medicamento sin leer el instructivo.

BRULUAGSA, S. A. de C. V.

Regs. Núms. 331M2001 y 327M2001, SSA

GEAR-105608/R2001 y GEAR-105607/R2001

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Nimotop - Pain Relief, Trinalion

Nimotop (Nimodipine) is in a group of drugs called calcium channel blockers. Nimodipine relaxes (widens) blood vessels and improves blood flow.

Nimodipine is used to prevent brain damage caused by reduced blood flow to the brain resulting from aneurysm (AN-yor-iz-m), a dilated or ruptured blood vessel in the brain.

Nimodipine may also be used for purposes other than those listed here.

Take nimodipine exactly as it was prescribed for you. Do not take it in larger doses or for longer than recommended by your doctor.

Nimodipine gel capsules are to be taken by mouth only. The medicine in the capsule should never be placed into a needle and syringe and injected into a vein. If the person taking nimodipine cannot swallow the capsule, use a needle to make a hole in each end of the capsule, and squeeze the medicine out into an oral syringe. The syringe can then be used to give the medicine through a nasogastric (through the nose and into the stomach) tube. If you are able to swallow capsules, take nimodipine on an empty stomach, one hour before or two hours after meals. Take each dose with a full glass of water.

It is important to take nimodipine regularly to get the most benefit. Do not stop taking nimodipine without first talking to your doctor, even if you begin to feel better. If you stop taking the medication, your condition could become worse.

To be sure this medication is helping your condition, your blood pressure will need to be tested on a regular basis. Your liver function may also need to be tested. It is important that you not miss any scheduled visits to your doctor.

Take the medicine as prescribed by your doctor.

Store nimodipine at room temperature away from moisture and heat.

Active ingredient: Nimodipine

Nimotop (nimodipine) belongs to the class of pharmacological agents known as calcium channel blockers.

Before taking nimodipine, tell your doctor if you have liver disease, low blood pressure, high blood pressure (hypertension) for which you take medicine, or a history of heart problems such as a slow heart rate, congestive heart failure, or heart attack.

Nimodipine gel capsules are to be taken by mouth only. The medicine in the capsule should never be placed into a needle and syringe and injected into a vein. If the person taking nimodipine cannot swallow the capsule, use a needle to make a hole in each end of the capsule, and squeeze the medicine out into an oral syringe. The syringe can then be used to give the medicine through a nasogastric (through the nose and into the stomach) tube.

If you are able to swallow capsules, take nimodipine on an empty stomach, one hour before or two hours after meals. Avoid drinking alcohol while you are taking nimodipine. Alcohol and nimodipine may cause low blood pressure, drowsiness, or dizziness. Do not stop taking nimodipine without first talking to your doctor, even if you begin to feel better. If you stop taking the medication, your condition could become worse.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known if nimodipine passes into breast milk or if it could harm a nursing infant. Do not take nimodipine without telling your doctor if you are breast-feeding a baby. If you are over 65 years of age, you may be more likely to have side effects from nimodipine. Your doctor may prescribe a lower dose of this medication.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using nimodipine and call your doctor at once if you have any of these serious side effects:

unusually fast or slow heartbeats;

fainting or severe dizziness;

easy bruising or bleeding, unusual weakness;

swelling in your legs or ankles.

Other, less serious side effects may be more likely. Continue taking nimotop and talk to your doctor if you have any of these less serious side effects:

flushing (redness, warmth, or tingling feeling);

nausea, constipation; or

Side effects other than those listed here may also occur.

Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

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Zaditor (Ketotifen) - No Prescription Needed, Zatotiten

Zaditor

Zaditor (Ketotifen) is an antihistamine that inhibits the body's release of a chemical called histamine. Histamine can produce allergy symptoms such as sneezing, runny nose, and watery eyes. Ketotifen ophthalmic is used to treat itching of the eyes caused by allergy to dust, pollen, animals, or other allergens.

Ketotifen ophthalmic may also be used for other purposes not listed in this medication guide.

Zaditor (Ketotifen) is an antihistamine that inhibits the body's release of a chemical called histamine. Histamine can produce allergy symptoms such as sneezing, runny nose, and watery eyes. Ketotifen ophthalmic is used to treat itching of the eyes caused by allergy to dust, pollen, animals, or other allergens.

Ketotifen ophthalmic may also be used for other purposes not listed in this medication guide.

Use this medication exactly as directed on the label, or as it has been prescribed by your doctor. Do not use the medication in larger amounts, or use it for longer than recommended.

Wash your hands before using the eye drops.

If you wear contact lenses, remove them before applying ketotifen ophthalmic. This medication may contain a preservative (benzalkonium chloride) that may cause discoloration of contact lenses.

To apply the eye drops:

Tilt your head back slightly and pull down your lower eyelid. Hold the dropper above the eye with the dropper tip down. Look up and away from the dropper as you squeeze out a drop, then close your eye. Gently press your finger to the inside corner of the eye (near your nose) for about 1 minute to keep the liquid from draining into your tear duct. If you use more than one drop in the same eye, wait about 5 minutes before putting in the next drop. Do not allow the dropper tip to touch any surface, including the eyes or hands. If the dropper becomes contaminated it could cause an infection in your eye, which can lead to vision loss or serious damage to the eye.

After using the eyedrops, wait at least 10 minutes before putting contact lenses into your eyes. Do not use the eye drops if the liquid has changed colors or has particles in it. Call your doctor for a new prescription. Store the drops at room temperature away from heat and moisture. Keep the bottle tightly closed when not in use.

Use this medication exactly as directed on the label, or as it has been prescribed by your doctor.

If you miss a dose of Zaditor, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Store Zaditor at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep in a tight, light-resistant container. Keep Zaditor out of the reach of children and away from pets.

Active Ingredient: Ketotifen (0.025%) (Antihistamine)

Do not use this medication if you are allergic to ketotifen, or if you have an untreated eye infection.

Do not use it if you you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement.

Ketotifen ophthalmic should not be used to treat eye irritation caused by wearing contact lenses.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether ketotifen passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Do not use this medication in a child younger than 3 years old without the advice of a doctor.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using ketotifen ophthalmic and call your doctor at once if you have any of these serious side effects:

redness, drainage, eyelid swelling, or other signs of infection;

vision changes; or

severe itching of the eyes worse than before using the medication.

Less serious side effects may include:

mild burning, stinging, or eye irritation;

dryness of the eyes; or

increased sensitivity to light.

This is not a complete list of side effects and others may occur. Tell your doctor or health care provider about any unusual or bothersome side effect.

Zaditor is to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

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Celg Stock Quote - Celgene Corporation Common Stock Price, Selgene

Celgene Corporation Common Stock Quote & Summary Data

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Company Description (as filed with the SEC)

Celgene Corporation, together with its subsidiaries (collectively "we," "our," "us," "Celgene" or the "Company"), is an integrated global biopharmaceutical company engaged primarily in the discovery, development and commercialization of innovative therapies for the treatment of cancer and inflammatory diseases through next-generation solutions in protein homeostasis, immuno-oncology, epigenetics, immunology and neuro-inflammation. Celgene Corporation was incorporated in the State of Delaware in 1986. Our primary commercial stage products include REVLIMID®, POMALYST®/IMNOVID®, ABRAXANE®, OTEZLA®, VIDAZA®, azacitidine for injection (generic version of VIDAZA®), THALOMID® (sold as THALOMID® or Thalidomide CelgeneTM outside of the United States), and ISTODAX®. In addition, we earn revenue through licensing arrangements. More.

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Fucedex, Fucedex

Fucidin (Fusidic Acid)

Fucidin is effective against several bacterial species and is used in the treatment of infections such as impetigo (characterised by blistering and yellowish-brown crusting of the skin), whitlow (paronchya) and inflammation of hair follicles (sycosis). It is also used to treat eczema or dermatitis that has become infected.

Use Fucidin as directed by your doctor. Apply a small amount to the lesion three or four times daily until favourable results are achieved. If your doctor has directed you to cover the lesion with a gauze dressing, less frequent applications (one or two daily) may be used. Avoid the eyes if the medication is being applied to the face. Ask your health care provider any questions you may have about how to use Fucidin.

Drug Class and Mechanism

Fucidin is an antibiotic medicine. It works by entering bacterial cells and interfering with the production of proteins that the bacteria need to divide and multiply. It does not directly kill the bacteria, but leaves them unable to increase in numbers. The existing bacteria eventually die or are destroyed by the immune system. Fusidic acid is included in this preparation to treat the bacteria that sometimes infect inflammatory skin diseases.

If you miss a dose of Fucidin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Store Fucidin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Keep Fucidin out of the reach of children and away from pets.

Organism overgrowth: Use of antibiotics applied to the skin occasionally allows overgrowth of organisms that are not killed by the antibiotic. If the infection does not improve within a few days or seems to get worse at any time, contact your doctor. Severe skin infections or infections that do not appear to heal with the use of a topical (skin-applied) medication should be treated with a systemic (oral or injectable) antibiotic in addition to or instead of a topical medication.

Pregnancy: The safety of this medication for treating infections during pregnancy has not been established. If its use by a pregnant woman is considered necessary, the potential benefits should be weighed against the possible risks. There is evidence to suggest that the medication can cross the placenta.

Breast-feeding: There is evidence to suggest that this medication passes into breast milk. The safety of this medication for treating infections in nursing women has not been established.

Possible Side Effects

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect. Skin rashes; Skin irritation; Stinging on application. The side effects listed above may not include all of the side effects reported by the drug's manufacturer. For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

Fucidin is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor.

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Tadapox Active ingredient: tadalafil $1.08 for pill Tadapox is a new combination tablet containing two of the most potent and effective pharmaceuticals proven to combat the major causes of male sexual. Metformin Active ingredient: metformin $0.26 for pill Metformin is a biguanide anti-diabetic that works by decreasing the amount of sugar that the liver produces and the intestines absorb.

Antabuse Active ingredient: Disulfiram $0.43 for pill Antabuse is used for treating alcoholism. Sildalis Active ingredient: tadalafil $0.95 for pill Sildalis is a combination drug, consisting both of Tadalafil and Sildenafil citrate (Viagra+Cialis). This combined medication is designed for the treatment.

Valtrex Active ingredient: Valacyclovir $2.66 for pill Valtrex is an antiviral drug used to treat herpes zoster, genital herpes, and herpes cold sores on the face and lips.

Viagra Active ingredient: Sildenafil $0.27 for pill Viagra is often the first treatment tried for erectile dysfunction in men and pulmonary arterial hypertension. Cialis Active ingredient: Tadalafil $0.68 for pill Cialis improves erection and helps to achieve a successful sexual intercourse.

Clomid Active ingredient: Clomiphene $0.44 for pill Clomid is a fertility drug, used to stimulate FSH and LH production and hereby the ovaries to produce eggs in ovarian disorders. ED Sample Pack 1 $2.31 for pill ED Sample Pack 1 consists of a two well-known medications (Viagra and Cialis) designed for the treatment of erectile dysfunction.

Brand Viagra Active ingredient: Sildenafil $2.56 for pill Brand Viagra is often the first treatment tried for erectile dysfunction in men and pulmonary arterial hypertension. Doxycycline $0.30 for pill Doxycyline is a tetracycline antibiotic used to treat infections of urinary tract, acne, gonorrhea, chlamydiosis, periodontitis, etc.

Propecia Active ingredient: Finasteride $0.51 for pill Propecia is used to treat hair loss (male pattern). Also it is used to treat prostate cancer and benign prostatic hyperplasia. Levitra Active ingredient: Vardenafil $1.00 for pill Levitra is used to treat sexual function problems such as Impotence or Erectile Dysfunction.

Amoxil Active ingredient: Amoxicillin $0.39 for pill Amoxil is an antibiotic from the penicillin group used to treat infections such as pneumonia, gonorrhea caused by E. coli, salmonella, etc. Viagra Professional Active ingredient: Sildenafil $0.57 for pill Viagra Professional is an extra-strength prescription medicine. It starts acting faster and the effect lasts longer that with regular Viagra.

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Dapoxetine Active ingredient: Dapoxetine $0.95 for pill Dapoxetine is used as a treatment for premature ejaculation. Zithromax Active ingredient: Azithromycin $0.40 for pill Zithromax is a macrolide antibiotic to treat infections of upper and low respiratory tract, especially ear infections, pneumonia.

Nolvadex Active ingredient: tamoxifen $0.52 for pill Nolvadex (Tamoxifen) is used for treating breast cancer in women. Cytotec Active ingredient: Misoprostol $1.70 for pill Cytotec prevents formation of stomach ulcers in patients treated by NSAIDs or arthritis or pain medicines.

Cialis Professional Active ingredient: Tadalafil $1.20 for pill Cialis Professional is essentially a "new and improved" formula of the original Cialis®. While the product has been reformulated and enhanced in its. Viagra Super Active Active ingredient: Sildenafil $1.25 for pill Viagra Super Active is created to deliver maximum effect in the shortest time. It will take you only 10 minutes to feel the result.

Extra Super Viagra Active ingredient: dapoxetine $2.86 for pill Extra Super Viagra is used in the treatment of Erectile Dysfunction with Premature Ejaculation. Extra Super Viagra contains Sildenafil100 mg and Dapoxetine. Cialis Extra Dosage Active ingredient: Tadalafil $2.05 for pill Cialis Extra Dosage is indicated for the treatment of erectile dysfunction. Cialis Extra Dosage works faster than other ED drugs and lasts for an extended.

Cialis Soft Active ingredient: Tadalafil $1.11 for pill Cialis Soft improves erection and helps to achieve a successful sexual intercourse. Viagra Soft Active ingredient: Sildenafil $0.91 for pill Viagra Soft is a chewable tablet. Absorbed directly into the bloodstream, it acts faster. It is used to treat erection problems in men. The time necessary.

Kamagra Active ingredient: Sildenafil $0.90 for pill Kamagra is used for the treatment of erectile dysfunction in men and pulmonary arterial hypertension. Cipro Active ingredient: Ciprofloxacin $0.22 for pill Cipro is an antibiotic in a group of drugs called fluoroquinolones. It is used to treat different types of bacterial infections, e. g. bladder inflammation.

Cialis Super Active Active ingredient: Tadalafil $1.32 for pill Cialis Super Active increases testosterone levels, possesses enhanced vasodilating effect, increases sperm production and sexual arousal, stamina, and. Extra Super Cialis Active ingredient: tadalafil $3.06 for pill Extra Super Cialis is used in the treatment of Erectile Dysfunction with Premature Ejaculation. Extra Super Cialis 100mg contains Tadalafil 40 mg and.

Female Viagra Active ingredient: Sildenafil $0.68 for pill Female Viagra improves woman's sexuality, increases sensitivity to stimulation, allows to reach an intense sexual satisfaction. Lasix Active ingredient: Furosemide $0.25 for pill Lasix belongs to a class of diuretics, it is prescribed in patients with swelling caused by congestive heart failure.

Zoloft Active ingredient: Sertraline $0.28 for pill Zoloft is a selective serotonin reuptake inhibitor to treat depression, posttraumatic stress disorder, panic disorder, certain types of social anxiety. Propranolol Active ingredient: propranolol $0.27 for pill Propranolol works by decreasing the action of pacemaker cells and slowing certain impulses in the heart.

Xenical Active ingredient: Orlistat $0.79 for pill Xenical (Orlistat) is recommended and prescribed by pharmacists as a weight loss medication that targets the absorption of fat in your body rather than. Prednisolone $0.32 for pill Prednisolone is used for treating allergies, arthritis, breathing problems (e. g. asthma), certain blood disorders, collagen diseases (e. g. lupus), certain.

Tadapox Active ingredient: tadalafil $1.08 for pill Tadapox is a new combination tablet containing two of the most potent and effective pharmaceuticals proven to combat the major causes of male sexual. Metformin Active ingredient: metformin $0.26 for pill Metformin is a biguanide anti-diabetic that works by decreasing the amount of sugar that the liver produces and the intestines absorb.

Antabuse Active ingredient: Disulfiram $0.43 for pill Antabuse is used for treating alcoholism. Sildalis Active ingredient: tadalafil $0.95 for pill Sildalis is a combination drug, consisting both of Tadalafil and Sildenafil citrate (Viagra+Cialis). This combined medication is designed for the treatment.

Valtrex Active ingredient: Valacyclovir $2.66 for pill Valtrex is an antiviral drug used to treat herpes zoster, genital herpes, and herpes cold sores on the face and lips.

Doxy-Tabs Oral Uses, Side Effects, Interactions, Pictures, Warnings - Dosing, Doxytab

Doxy-Tabs

GENERIC NAME(S): DOXYCYCLINE HYCLATE

Uses

This medication is used to treat a wide variety of bacterial infections. including those that cause acne. This medication is also used to prevent malaria. This medication is known as a tetracycline antibiotic. It works by stopping the growth of bacteria.

This antibiotic treats only bacterial infections. It will not work for viral infections (such as common cold. flu ). Unnecessary use or misuse of any antibiotic can lead to its decreased effectiveness.

OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.

This drug may also be used to treat a certain skin condition (rosacea ).

How to use Doxy-Tabs

This medication is best taken by mouth on an empty stomach. at least 1 hour before or 2 hours after a meal, usually 1 or 2 times daily or as directed by your doctor. Take this medication with a full glass of water (8 ounces/240 milliliters) unless directed otherwise. If stomach upset occurs, taking it with food or milk may help. However, doxycycline may not work as well if you take it with food or milk (or anything high in calcium - more details below ), so ask your doctor or pharmacist if you may take it that way. Do not lie down for 10 minutes after taking this medication.

Take this medication 2 to 3 hours before or after taking any products containing aluminum, calcium. iron, magnesium. zinc, or bismuth subsalicylate. Some examples include antacids, didanosine solution, quinapril. vitamins /minerals, dairy products (such as milk, yogurt), and calcium - enriched juice. These products bind with doxycycline, preventing your body from fully absorbing the drug.

When using to prevent malaria, this medication is usually taken once daily. Take the first dose of this medication 1 to 2 days before travel or as directed by your doctor. Continue to take this medication daily while in the malarious area. Upon returning home, you should keep taking this medication for 4 more weeks. If you are unable to finish this course of doxycycline, contact your doctor.

If you are using the liquid form of this medication, shake the bottle well before each dose. Carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.

The dosage is based on your medical condition and response to treatment. For children, the dosage may also be based on weight .

Antibiotics work best when the amount of medicine in your body is kept at a constant level. Therefore, take this drug at evenly spaced intervals.

Continue to take this medication until the full prescribed amount is finished, even if symptoms disappear after a few days. Stopping the medication too early may allow bacteria to continue to grow, which may result in a return of the infection.

Tell your doctor if your condition persists or worsens.

Side Effects

Stomach upset, diarrhea. nausea. or vomiting may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: sunburn (sun sensitivity), painful/difficult swallowing, signs of kidney problems (such as change in the amount of urine).

Tetracycline drugs such as doxycycline may rarely cause a serious increase in pressure inside the skull (intracranial hypertension - IH). The risk of this side effect is greater for women of childbearing age who are overweight or who have had IH in the past. If IH develops, it usually goes away after doxycycline is stopped; however, there is a chance of permanent vision loss or blindness. Get medical help right away if you have: persistent/severe headache. vision changes (such as blurred/double vision. decreased vision. sudden blindness), persistent nausea/vomiting.

This medication may rarely cause a severe intestinal condition (Clostridium difficile - associated diarrhea) due to a type of resistant bacteria. This condition may occur during treatment or weeks to months after treatment has stopped. Do not use anti-diarrhea products or narcotic pain medications if you have any of the following symptoms because these products may make them worse. Tell your doctor right away if you develop: persistent diarrhea, abdominal or stomach pain /cramping, blood /mucus in your stool.

Use of this medication for prolonged or repeated periods may result in oral thrush or a new vaginal yeast infection. Contact your doctor if you notice white patches in your mouth. a change in vaginal discharge. or other new symptoms.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction. including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness. trouble breathing .

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

See also Side Effects section.

Before taking doxycycline, tell your doctor or pharmacist if you are allergic to it; or to other tetracyclines (such as minocycline); or if you have any other allergies. This product may contain inactive ingredients (such as sulfites, soy found in some brands), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: trouble swallowing, esophagus problems (such as hiatal hernia or reflux/heartburn).

Before having surgery, tell your doctor or dentist that you are taking this medication.

This medication may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen and wear protective clothing when outdoors.

Children younger than 8 years may be more sensitive to the side effects of doxycycline, especially tooth discoloration. Tooth discoloration has also occurred in older children and young adults. Discuss the risks and benefits of this medication with the doctor.

This medication is not recommended for use during pregnancy. It may harm an unborn baby. Consult your doctor for more details.

This drug passes into breast milk but is unlikely to harm a nursing infant. Consult your doctor before breast-feeding.

Interactions

See also How to Use section.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: retinoid medications taken by mouth (such as acitretin, isotretinoin), barbiturates (such as phenobarbital), "blood thinners" (such as warfarin), digoxin, anti-seizure medications (such as carbamazepine, phenytoin), strontium, live bacterial vaccines.

Although most antibiotics (including doxycycline) are unlikely to affect hormonal birth control such as pills, patch, or ring, a few antibiotics (such as rifampin, rifabutin) can decrease their effectiveness. This could result in pregnancy. If you use hormonal birth control, ask your doctor or pharmacist for more details.

This medication may interfere with certain laboratory tests (including urine catecholamine levels), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

Overdose

If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Notes

Do not share this medication with others.

If this medication is being used to prevent malaria, it is important to understand that it is still possible to get the disease even if you have used this medication. Avoid being bitten by mosquitoes when trying to prevent malaria. Avoid contact with mosquitoes, especially from dusk to dawn, by staying in well-screened areas, wearing protective clothing, and using insect repellent and bed nets.

This medication has been prescribed for your current condition only. Do not use it later for another infection unless told to do so by your doctor. A different medication may be necessary in that case.

Laboratory and/or medical tests (such as complete blood count, liver/kidney function) may be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store at room temperature away from light and moisture. Different brands of this medication have different storage needs. Check the product package for instructions on how to store your brand, or ask your pharmacist. Do not store in the bathroom. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Taking outdated tetracycline-related drugs can result in serious illness. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Information last revised May 2016. Copyright(c) 2016 First Databank, Inc.

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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Terbinafinum, Terbinafinum

Terbinafine

Click for further information on drug naming conventions and International Nonproprietary Names .

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Sinovial, Sinovial

synovial

References in periodicals archive ?

1,7,9) MRI findings include a synovial mass, fat signal intensity on all sequences, suppression of signal with fat-selective presaturation, joint effusion, and absence of MRI supporting hemosiderin.

All sections from each mouse were scored individually by a blinded observer on a scale of 0-3 as follows: 0 = normal, 1 = infiltration of inflammatory cells, 2 = synovial hyperplasia and pannus formation, 3 = bone erosion and destruction.

Ganglions and synovial cysts around the elbow are known to be a common phenomenon.

Joint space narrowing was also independently associated with the US features of synovial thickening (OR, 3.

Until the advent of electronic cell counters, the unique properties of synovial fluid mandated labor-intensive and time-consuming manual techniques.

Case report 817: Synovial chondrosarcoma secondary to synovial chondromatosis.

Synovial sarcomas are high-grade soft-tissue tumors that show a predilection for males (male-to-female ratio: 3 to 2); they typically occur in the third decade of life.

Though not very specific, a combination of the following signs in an appropriate clinical setting (young age, juxta-articular location) suggest a diagnosis of synovial sarcoma on MR imaging: (4,5)

have shown that inhibition of DPP-4 increases cartilage invasion by rheumatoid arthritis synovial fibroblasts.

In addition, for some types of cancers (such as synovial sarcoma), every individual tumor sample examined had a mutation in a BAF subunit.

In this report, we discuss the differential considerations for intraarticular masses and the clinical presentation of metastatic synovial disease.

After radiography and ultrasound, the differential diagnosis was rice body formation or synovial chondromatosis.

Histamine Phosphate Side Effects In Detail, Histazine

Histamine phosphate Side Effects

Applies to histamine phosphate: intradermal injectable, intradermal solution

In addition to its needed effects, some unwanted effects may be caused by histamine phosphate. In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking histamine phosphate, check with your doctor or nurse immediately:

More common:

Dizziness

fainting

fast or pounding heartbeat

headache (continuing or severe)

lightheadedness

nervousness

Less common or rare:

Bluish coloration of face

blurred vision

chest discomfort or pain

convulsions (seizures)

decrease in blood pressure (sudden)

diarrhea (severe)

difficulty with breathing

flushing or redness of the face

nausea and vomiting (severe)

Minor Side Effects

Some of the side effects that can occur with histamine phosphate may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:

Abdominal spasms or cramps

diarrhea

metallic taste

nausea or vomiting

stomach pain

swelling or redness at the place of injection

Not all side effects for histamine phosphate may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here .

More about histamine phosphate

Consumer resources

Professional resources

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill. knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs. com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

Drug Status

Oftulix, Oftulix

Diclofenac is used to treat pain or inflammation caused by arthritis or ankylosing spondylitis. Diclofenac may also be used for purposes other than those listed in this medication guide.

Use Diclofenac as directed by your doctor.

Take Diclofenac by mouth with or without food. Ask your health care provider any questions you may have about how to use Diclofenac.

Drug Class and Mechanism

Diclofenac is in a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Diclofenac works by reducing hormones that cause inflammation and pain in the body.

If you miss a dose of Diclofenac, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Store Diclofenac at room temperature between 68 and 77 degrees F (20 and 25 degrees C) in a tightly closed container. Brief periods at temperatures of 59 to 86 degrees F (15 to 30 degrees C) are permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Diclofenac out of the reach of children and away from pets.

Do not use Diclofenac if:

you are allergic to any ingredient in Diclofenac; you have had a severe allergic reaction (e. g. severe rash, hives, breathing difficulties, dizziness) to another NSAID (e. g. ibuprofen, naproxen, celecoxib) or aspirin. Contact your doctor or health care provider right away if any of these apply to you.

Important : Diclofenac may cause dizziness or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Diclofenac with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. Before you start any new medicine, check the label to see if it has Oftulix or another nonsteroidal anti-inflammatory drug (NSAID) medicine in it too. If it does or if you are not sure, check with your doctor or pharmacist. Diclofenac should not be used in children; safety and effectiveness in children have not been confirmed. Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Diclofenac while you are pregnant. It is not known if Diclofenac is found in breast milk. Do not breast-feed while using Diclofenac.

Possible Side Effects

Check with your doctor if any of these most common side effects persist or become bothersome:

burning or stinging; discharge; eye redness, irritation, or itching. Seek medical attention right away if any of these severe side effects occur:

severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred or distorted vision; eye infection; eyelid swelling or redness; sensitivity to glare or light.

Diclofenac is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor.

Lamivudine Dosage Guide With Precautions, Lamivur

Lamivudine Dosage

Usual Adult Dose for HIV Infection

150 mg orally twice a day or 300 mg orally once a day

Use: In combination with other antiretroviral agents, for the treatment of HIV-1 infection

Usual Adult Dose for Chronic Hepatitis B

100 mg orally once a day Duration of therapy: The optimal duration of therapy is not known.

Use: For the treatment of chronic HBV infection associated with evidence of hepatitis B viral replication and active liver inflammation

Usual Adult Dose for Nonoccupational Exposure

US CDC recommendations: 150 mg orally twice a day or 300 mg orally once a day Duration of therapy: 28 days

Comments : - Recommended as part of preferred regimens for nonoccupational postexposure prophylaxis of HIV infection; this drug should be used with efavirenz plus (zidovudine or tenofovir) or with lopinavir-ritonavir plus zidovudine. - Also recommended as a component in various alternative regimens (NNRTI-based, protease inhibitor-based, or triple NRTI) - Prophylaxis should be started as soon as possible, within 72 hours of exposure. - Current guidelines should be consulted for additional information.

Usual Adult Dose for Occupational Exposure

US Public Health Service working group recommendations : - Preferred dose: 300 mg orally once a day - Alternative dose: 150 mg orally twice a day Duration of therapy: 28 days, if tolerated

Comments : - Recommended as a component in various alternative regimens for HIV postexposure prophylaxis - Prophylaxis should be started as soon as possible, preferably within hours after exposure. - The optimal duration of prophylaxis is unknown and may differ based on institution protocol. - Current guidelines should be consulted for additional information.

Usual Pediatric Dose for HIV Infection

3 months or older : Oral solution: 4 mg/kg orally twice a day or 8 mg/kg orally once a day - Maximum dose: 300 mg/day

Tablets : 14 to less than 20 kg: 75 mg orally twice a day or 150 mg orally once a day 20 to less than 25 kg: 75 mg orally in the morning and 150 mg in the evening, or 225 mg orally once a day 25 kg or more: 150 mg orally twice a day or 300 mg orally once a day

Comments : - For patients starting therapy with the oral solution, HIV-1 viral load and CD4+ cell count/percentage should be considered when selecting dosing interval.

Use: In combination with other antiretroviral agents, for the treatment of HIV-1 infection

Panel on Antiretroviral Therapy and Medical Management of HIV-infected Children Recommendations : Oral solution : Less than 4 weeks (for prevention of transmission or treatment): 2 mg/kg orally twice a day 4 weeks to less than 3 years: 4 mg/kg orally twice a day - Maximum dose: 150 mg/dose 3 years to less than 16 years: 4 mg/kg orally twice a day or 8 to 10 mg/kg orally once a day - Maximum dose: 300 mg/day

Tablets : 14 to 21 kg: 75 mg orally twice a day Greater than 21 to less than 30 kg: 75 mg orally in the morning and 150 mg in the evening 30 kg or more: 150 mg orally twice a day

16 years or older : Less than 50 kg: 4 mg/kg orally twice a day - Maximum dose: 150 mg/dose 50 kg or more: 150 mg orally twice a day or 300 mg orally once a day

Comments : - May consider switching from twice-daily dosing to once-daily dosing of this drug in clinically stable patients 3 years or older with a reasonable once-daily regimen, an undetectable viral load, and stable CD4 count; a dose of 8 to 10 mg/kg/dose (up to 300 mg/day) is recommended for such patients.

Usual Pediatric Dose for Chronic Hepatitis B

2 years or older: 3 mg/kg orally once a day Maximum dose: 100 mg/day Duration of therapy: The optimal duration of therapy is not known.

Use: For the treatment of chronic HBV infection associated with evidence of hepatitis B viral replication and active liver inflammation

Renal Dose Adjustments

HBV Infection : Adults : - CrCl 30 to 49 mL/min: 100 mg orally as first dose, then 50 mg orally once a day - CrCl 15 to 29 mL/min: 100 mg orally as first dose, then 25 mg orally once a day - CrCl 5 to 14 mL/min: 35 mg orally as first dose, then 15 mg orally once a day - CrCl less than 5 mL/min: 35 mg orally as first dose, then 10 mg orally once a day

Pediatric patients: Insufficient data to recommend a specific dose

HIV Infection : Adults and Adolescents (at least 25 kg) : - CrCl 30 to 49 mL/min: 150 mg orally once a day - CrCl 15 to 29 mL/min: 150 mg orally as first dose, then 100 mg orally once a day - CrCl 5 to 14 mL/min: 150 mg orally as first dose, then 50 mg orally once a day - CrCl less than 5 mL/min: 50 mg orally as first dose, then 25 mg orally once a day

Pediatric patients: Insufficient data to recommend a specific dose; reduction in dose and/or increase in dosing interval should be considered.

Liver Dose Adjustments

No adjustment recommended.

Comments : - Safety and efficacy have not been established in patients with decompensated liver disease.

Precautions

US BOXED WARNINGS : - LACTIC ACIDOSIS AND SEVERE HEPATOMEGALY WITH STEATOSIS: Lactic acidosis and severe hepatomegaly with steatosis (including fatalities) reported with use of nucleoside analogs and other antiretrovirals. This drug should be discontinued if clinical or laboratory findings suggest lactic acidosis or pronounced hepatotoxicity. - EXACERBATIONS OF HEPATITIS B: Severe acute exacerbations of hepatitis B reported in patients with HBV (including those coinfected with HIV-1) after stopping this drug. Hepatic function of HBV-infected patients should be closely monitored with clinical and laboratory follow-up for at least several months after stopping this drug. If appropriate, initiation/resumption of antihepatitis B therapy may be necessary. - IMPORTANT DIFFERENCES AMONG LAMIVUDINE-CONTAINING PRODUCTS: Epivir(R) tablets and oral solution (for use in HIV-1 infection) contain a higher dose of lamivudine than Epivir-HBV(R) tablets and oral solution (for use in chronic HBV infection). Only products appropriate for treatment of HIV-1 should be used in HIV-1-infected patients. - HIV-1 RESISTANCE RISK WITH EPIVIR-HBV(R) USE IN UNRECOGNIZED/UNTREATED HIV-1 INFECTION: Epivir-HBV(R) is not approved for treatment of HIV-1 infection; lamivudine dose is subtherapeutic and monotherapy is inappropriate. HIV-1 resistance may develop in chronic HBV-infected patients with unrecognized or untreated HIV-1 infection. HIV counseling and testing should be offered to all patients before starting Epivir-HBV(R) and periodically during therapy.

Safety and efficacy of Epivir(R) and Epivir-HBV(R) have not been established in patients younger than 3 months and 2 years, respectively.

Consult WARNINGS section for additional precautions.

Dialysis

Conventional 4-hour hemodialysis and peritoneal dialysis: No additional dose adjustments needed after adjustment for renal dysfunction (based on CrCl); no supplemental dose needed after dialysis. Prolonged or continuous hemodialysis: Data not available

Other Comments

Administration advice : - May administer without regard to food - If patient is unable to reliably swallow a tablet, use the oral solution. - Only use products appropriate for treatment of HIV-1 in patients with HIV-1 infection; use in combination with other antiretroviral agents. - Use the formulation and dose recommended for HIV-1 therapy (as part of an appropriate combination regimen) in patients coinfected with HIV-1 and HBV. - Consult the manufacturer product information regarding missed doses.

Storage requirements : - Oral solutions: Store in tightly closed bottles at 20C to 25C (68F to 77F) - Tablets: Store at 25C (77F); excursions permitted to 15C to 30C (59F to 86F).

General : - Due to development of high resistance rates in treated patients, starting this drug for treatment of chronic HBV should only be considered when an alternative antiviral with a higher genetic barrier to resistance is not available or appropriate. - During HBV therapy, combinations of events (e. g. persistently elevated ALT recurring, HBV DNA levels increasing over time after initial decline below assay limit, clinical signs/symptoms of hepatic disease progression, and/or hepatic necroinflammatory findings worsen) may indicate loss of therapeutic response; such events should be considered when deciding whether to continue this drug. - The durability of hepatitis B e antigen (HBeAg) seroconversions occurring during HBV therapy and the relationship between treatment response and long-term outcomes (e. g. hepatocellular carcinoma, decompensated cirrhosis) have not been established. - The oral solutions contain sucrose; Epivir(R) contains 3 g sucrose per 15 mL dose and Epivir-HBV(R) contains 4 g sucrose per 20 mL dose.

Monitoring : - Gastrointestinal: For signs/symptoms of pancreatitis in pediatric patients - General: HIV testing (before starting and periodically during HBV therapy) - Hepatic: ALT and HBV DNA levels (during HBV therapy); hepatic function of HBV-infected patients with clinical and laboratory follow-up (for at least several months after stopping therapy) - Renal: Renal function in elderly patients

Amphetamine Sulfate, Alentol

CAMEO Chemicals

AMPHETAMINE SULFATE

The Response Recommendation fields include isolation and evacuation distances, as well as recommendations for firefighting, non-fire response, protective clothing, and first aid. The information in CAMEO Chemicals comes from a variety of data sources.

Isolation and Evacuation

Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:

As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.

SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above.

FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Fires involving this compound should be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

STORAGE PRECAUTIONS: You should protect this chemical from exposure to light and moisture, and store it at ambient temperatures. This compound is a Schedule II DEA Controlled Substance and is to be stored according to State and Federal Regulations. Refer to Code of Federal Regulations Title 21 Part 1300 to End. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i. e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter). (NTP, 1992)

DuPont Tychem® Suit Fabrics

No information available.

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.

INGESTION: If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Generally, the induction of vomiting is NOT recommended outside of a physician's care due to the risk of aspirating the chemical into the victim's lungs. However, if the victim is conscious and not convulsing and if medical help is not readily available, consider the risk of inducing vomiting because of the high toxicity of the chemical ingested. Ipecac syrup or salt water may be used in such an emergency. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

The Physical Property fields include properties such as vapor pressure and boiling point, as well as explosive limits and toxic exposure thresholds. The information in CAMEO Chemicals comes from a variety of data sources.

Eiffel Tower - Tour Eiffel, Paris, Eifel

The Eiffel Tower, an immense stucture of exposed latticework supports made of puddle iron. was erected for the Paris Exposition of 1889. The Prince of Wales (later King Edward VII of England) officiated at the ceremonial opening. Of the 700 proposals submitted in a design competition, one was unanimously chosen, a radical creation from the French structural engineer Alexandre Gustave Eiffel (b. Dec. 15, 1832, d. Dec. 28, 1923), who was assisted in the design by engineers Maurice Koechlin and Emile Nouguier, and architect Stephen Sauvestre.

However, the controversial tower elicited some strong reactions, and a petition of 300 names — including those of Guy de Maupassant, Émile Zola, Charles Garnier (architect of the Opéra Garnier), and Alexandre Dumas fils — was presented to the city government, protesting its construction. The petition read, "We, the writers, painters, sculptors, architects and lovers of the beauty of Paris, do protest with all our vigour and all our indignation, in the name of French taste and endangered French art and history, against the useless and monstrous Eiffel Tower."

Nature lovers thought that it would interfere with the flight of birds over Paris. But the Eiffel Tower was admired by Rousseau, Utrillo, Chagall, and Delaunay. It was almost torn down in 1909 at the expiration of its 20-year lease, but was saved because of its antenna — used for telegraphy at that time. Beginning in 1910 it became part of the International Time Service. French radio (since 1918), and French television (since 1957) have also made use of its stature. In the 1960s, it was the subject of a wonderful study by semiologist Roland Barthes.

Eiffel Tower under construction

Built to celebrate the science and engineering achievements of its age, soaring 300m / 984 ft. (320.75m / 1,052 ft. including antenna) and weighing 7000 tons, the structure consists of two visibly distinct parts: a base composed of a platform resting on four separate supports (called pylons or bents) and, above this, a slender tower created as the bents taper upward, rising above a second platform to merge in a unified column.

This unprecedented work, the tallest structure in the world until the Empire State Building was built about 40 years later, had several antecedents. Among them were the iron-supported railway viaducts designed by Eiffel, an arch bridge over the Douro River in Portugal with a span of 160 m (525 ft), and a design for a circular, iron-frame tower proposed by the American engineers Clarke and Reeves for the Centennial Exposition of 1876. Eiffel knew and publicly acknowledged this influence; he was no stranger to the United States, having designed the wrought-iron pylon inside Frederic Bartholdi's Statue of Liberty in 1885. Later in the same year, he had also begun work on the cupola of the Nice observatory.

Eiffel was the leading European authority on the aerodynamics of high frames (he wrote "The Resistance of the Air" in 1913). In the construction of the Eiffel Tower, the curve of the base pylons was precisely calculated so that the bending and shearing forces of the wind were progressively transformed into forces of compression, which the bents could withstand more effectively. Such was Eiffel's engineering wizardry that even in the strongest winds his tower never sways more than 4-1/2 inches. The superskyscrapers erected since 1960, such as the World Trade Center, were constructed in much the same way.

However difficult its birth may have been, the Tour Eiffel is now completely accepted by French citizens, and is internationally recognized as one of the symbols of Paris itself.

Facilities and Views

In the basements of the eastern and western pillars, one can visit the gargantuan 1899 machinery which powers the elevators, an astonishing spectacle reminiscent of a Jules Verne novel. From the Tower's three platforms — especially the topmost — the view of Paris is superb. It is generally agreed that one hour before sunset, the panorama is at its best; don't forget to bring your camera, and experiment with the f-stop settings to capture a dazzling sunset on the Seine. If you can't be there in person, then check out a Live Aerial View of Paris with TF1's webcam online: from the top of the Eiffel Tower, you can see Paris in real time, 24 hours a day, whatever the weather conditions in the French capital. To get the most out of this view of Paris, we suggest you surf their web site between 7:00 AM and 9:00 PM GMT (1:00 AM and 3:00 PM Eastern Time in the U. S.), when the City of Light is at its best.

Eiffel Tower by Susan Gillette 14" x 18" fine art print BUY THIS PRINT

First level . 57.63 meters (189 feet). Observatory from which to study the movements of the Eiffel Tower's summit. Kiosk presentation about the mythic painting of the Eiffel Tower. Space CINEIFFEL: offers an exceptional panorama of sights from the Tower. Souvenir shops (yes, every tourist MUST have a miniature replica). Restaurant "Altitude 95" (phone 01-45-55-20-04). Post office, with special stamps "Paris Eiffel Tower ". Panoramic gallery displaying the Monuments of Paris.

Second level . 115.73 meters (379 feet, 8 inches). Panorama of Paris. Telescopes, shops. Animated displays on the operation of the elevators. Jules Verne Restaurant (extremely expensive, reservations absolutely necessary; phone 01-45-55-61-44).

Third level . 276.13 meters (905 feet, 11 inches). Exceptional panoramic views, day or night, of Paris and its surroundings. Recently restored office, featuring wax reproductions of Gustave Eiffel and Thomas Edison in conversation (see photo. Panoramic guide displays to aid orientation. Dioramas presenting the history of this platform.

Probably the best approach to the tower is to take the Métro to the Trocadéro station and walk from the Palais de Chaillot to the Seine. Besides fabulous views, especially when the Trocadéro fountains are in full force, you get a free show from the dancers and acrobats who perform around the Palais de Chaillot. The vast green esplanade beneath the tower is the Parc du Champs-de-Mars, which extends all the way to the 18th-century École Militaire (Military Academy), at its southeast end. This formal lawn was once a parade ground for French troops.

The Eiffel Tower at night is one of the great sights of Paris and shouldn't be missed. The gold lighting highlights the delicacy of the steelwork in a way that is missed in daylight. Skip the tour buses and pickpockets on Trocadéro and head up to the École Militaire for a more tranquil view.

Interesting Facts

300 steel workers, and 2 years (1887-1889) to construct it.

15,000 iron pieces (excluding rivets).

2.5 million rivets.

40 tons of paint.

1671 steps to the top.

Maximum sway at top caused by wind: 12 cm (4.75 inches).

Maximum sway at top caused by metal dilation: 18 cm (7 inches).

Total height in 1889: 300.51 meters (985 feet, 11 inches).

Total height with television antenna: 320.755 meters (1052 feet, 4 inches).

Height varies up to 15 cm depending on temperature.

Size of base area: 10,281.96 square meters (2.54 acres).

Weight of foundations: 277,602 kg (306 tons).

Weight of iron: 7.34 million kg (8092.2 tons).

Weight of elevator systems: 946,000 kg (1042.8 tons).

Total weight: 8.56 million kg (9441 tons).

Pressure on foundation: 4.1 to 4.5 kg per square centimeter, depending on pier (58.26 to 64 lbs. per square inch).

Dates of construction: January 26, 1887 to March 31, 1889.

Cost of construction: 7.8 million francs ($1.5 million).

Total number of visitors during 1889 Exposition: 1,968,287.

Total receipts during 1889 Exposition: 5,919,884 francs ($1.14 million).

Total number of visitors during 2007: 6,822,000.

During its lifetime, the Eiffel Tower has witnessed a few strange scenes, including being scaled by a mountaineer in 1954, and two Englishmen parachuting off it in 1984. In 1923, the journalist Pierre Labric (who was later to become mayor of Montmartre) rode a bicycle down from the first level; some accounts say he rode down the stairs, others suggest the exterior of one of the tower's four legs which slope outward.

Politics have also played a role in its life. During World War II, the Germans hung a sign on it that read: "Deutschland Siegt Auf Allen Fronten" ("Germany is victorious on all fronts"). In 1958, a few months before Fidel Castro's rise to power, Cuban revolutionaries hung their red-and-black flag from the first level, and, in 1979, an American from Greenpeace hung one that read: "Save the Seals". In 1989, the Tower celebrated its centennial with music and fireworks (the show lasted 89 minutes).

Operation

The Eiffel Tower is owned by the City of Paris, which has subcontracted its maintenance and daily operations since 2005 to SETE ( Société d'Exploitation de la Tour Eiffel ), a public utility.

More than 500 people bring the Eiffel Tower to life each day. About one half are employed by SETE, the others are concessionaires (souvenir boutiques, restaurants, telescope operations, ATMs, behind-the-scene tours) and civil service employees (police, fire personnel, post office, weather).

Location . 5, avenue Anatole France, Champ de Mars, 75007 Paris. Phone . 01-44-11-23-11 ; guided tours: 08-25-05-44-05. Operation . Open every day of the year. Hours . January 1 - June 12, 9:30 a. m. - 11:00 p. m. (elevator), 9:30 a. m. - 6:30 p. m. (stairs). June 13 - August 31, 9:00 a. m. - midnight (both elevator & stairs); September 1 - December 31, 9:30 a. m. - 11:00 p. m. (elevator), 9:30 a. m. - 6:30 p. m. (stairs). Price of admission (tax included): By elevator — 1st floor: 4.80€/adult, 2.50€/child (under 12); 2nd floor: 7.80€/adult, 4.30€/child ; top floor: 12.00€/adult, 6.70€/child. On foot (stairs) — up to 2nd floor only: 4.00€/age 25+, 3.10€/age under 25. Children under 3 free. See web site for group rates. Disabled access . At each of the three pillars with an elevator, access is free of any steps or turnstiles. Visitors with reduced mobility may access the 1st and 2nd floors only. For safety reasons (notably, in case of emergency evacuation), the top floor is not accessible to visitors in wheelchairs. Security measures . No large-sized hand baggage or animals allowed (except for Seeing Eye dogs). Hand-bags may be inspected by security personnel. There is no baggage check service available at the Tower. Métro . Bir-Hakeim (line 6), Trocadéro (lines 6, 9). RER . Champ-de-Mars. Buses . 42, 69, 72, 82, 87. Web site . http://www. tour-eiffel. fr/. E-mail . lrobin@toureiffel. fr (Public Relations).

Edited by Ian C. Mills, © 2008-- – All Rights Reserved. Bibliography and recommended reading: Grolier Multimedia Encyclopedia v9.0.1. 1997, Grolier Interactive Inc. Danbury, CT. The Wind Bracing of High Buildings, Carl W. Condit, Scientific American, February 1974. Space, Time and Architecture: The Growth of a New Tradition. 5th ed. Siegfried Giedion, 1967. The Tallest Tower - Eiffel and the Belle Epoque. Joseph Harris, 1975, repr. 1989, Houghton Mifflin Co. Boston (out-of-print). The Eiffel Tower: A Centenary Celebration. Françoise Sagan, 1989 (out-of-print). The Eiffel Tower, Gaston Tissandier, 1889. Elevator Systems of the Eiffel Tower - 1889, Robert M. Vogel, 1961. Pleasures of the Belle Epoque: Entertainment & Festivity in Turn of the Century France. Charles Rearick, 1985, Yale University Press, printed by Murray Printing Co. Westford, Massachusetts. The Eiffel Tower and Other Mythologies. Roland Barthes, translated by Richard Howard, 1997, University of California Press. Modern Marvels - The Eiffel Tower (video tape), A&E, 1994. The Eiffel Tower: Scale Architectual Paper Model. Georges Gardize and Christian Tijou, 1986. Around and About Paris, Volume 1: From the Dawn of Time to the Eiffel Tower (Arrondissements 1-7). Thirza Vallois, 1995, Iliad Books, London. Frommer's Paris From $95 A Day. Haas Mroue, 2006, Wiley Publishing Inc. Hoboken, New Jersey. Fodor's 2008 Paris. Fodor's Travel Publications, Inc. published in the U. S. by Random House, Inc. New York. The Columbia Viking Desk Encyclopedia. Third Edition, copyright Columbia University Press, 1968, Viking Press Inc. New York (out-of-print). Online sources: La Tour Eiffel. the official web site of the Tower. Wikipedia. the Free Encyclopedia (web site). Image credits: "Eiffel Tower " by Susan Gillette, from Art. com. "Construction of the Eiffel Tower, Avril 1888 - Mai 1889 " (photographer unknown), © Nouvelles Images, from Art. com. "Eiffel Tower " (photographer unknown), © NAGR - Eurographics, from Art. com. — All Rights Reserved.

Sage Intelligence Academy, Alcamex

Welcome to the Sage Intelligence Academy

Expand your reporting knowledge with Sage Intelligence and Excel on Steroids courses anytime, anywhere.

Our approach to learning and development ensures you are fully equipped to deliver to your customer. From specialist training on the Sage Intelligence product through to developing your inner Excel guru, the online courses on the Sage Intelligence Academy will help you to develop your reporting skills.

Sage Intelligence Beginner Course

New to Sage Intelligence? Have a basic understanding of Excel? In this course you will get a comprehensive overview of Sage Intelligence and learn the basic functions of the Report Manager. MORE INFO

Sage Intelligence Intermediate Course

Time to take your reporting to the next level? This course is designed for you if you have a basic working knowledge of the Report Manager and want to fully utilize its capabilities. MORE INFO

Sage Intelligence Advanced Course

Ready to start consolidating your data and customizing your reports? Learn how to fully customize the way your data is extracted from a data source with the Connector module. MORE INFO

Financial Report Designer Course

You now have a good knowledge of Sage Intelligence are ready to design your reports using the Layout Generator and the Task Pane, in the Report Designer. MORE INFO

Courses

What’s New in Excel 2016

Get a taste of the exciting new and improved business reporting features. This short interactive course gives you hands-on experience with impressive charts to help you enrich your reports, new functions, enhanced PivotTable functionality such as automatic time grouping, one-click forecasting capabilities, and your new secret weapon, the handy “Tell Me” text box. This one’s on us – just another way Sage Intelligence is helping you work smarter.

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Sage Intelligence is a Microsoft® Excel® based reporting tool that pulls data from Sage X3 and delivers it in an Excel format that is easy to understand and manipulate, putting you in control of the design of your reports.

Sage Intelligence – Three Course BUNDLE

Get to grips with Sage Intelligence. If you’re using version 7.3 of the Sage Intelligence reporting tool, this online course will teach you how to use its features to design customized reports based on your business requirements. Features covered in this online course include the Report Manager, report scheduling and connecting to a database. It is available at beginners, intermediate and advanced levels. Save money and buy a BUNDLE.

Sage 100 Contractor Intelligence Reporting – Getting Started Course

You've heard about Sage 100 Contractor Intelligence Reporting, how about giving it a try for yourself? Take a look at this FREE introductory course that will show you how to activate Sage Intelligence and take advantage of the out-the-box reports. We will also show you how to customize standard reports and save them for future use. You will also see some basic Excel functions.

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If you already have access to this course, please login to the LMS to start the course. If you don‘t have access to this course and would like to gain access, please follow these steps: - Send an e-mail to your line manager requesting access to the course - Please include the following information in the e-mail to your manager: 1. Employee number 2. Name 3. Surname 4. Name of the course - Your manager will forward your request to the Learning department, who will notify you if and when access to this course is granted - After access is granted, please sign in to the LMS to start the course.

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Pantomucol Para Que Sirve, Pantomucol

PANTOMUCOL

Tenga especial cuidado durante el embarazo .

No usar PANTOMUCOL con lactantes.

Revise siempre que no sea alergico a ninguno de los componentes de PANTOMUCOL . podria poner en peligro su salud

Recuerda antes de tomar este medicamento consultar siempre con su medico, la informacion que ofrecemos es orientativa y no sustituye en ningun caso la de su medico u otro profesional de la salud.

Prospecto e indicaciones

ABBOTT LABORATORIOS S. A.

Lima - Peru

Av. Brasil 2730, Pueblo Libre Tel: 219-3300 Fax: 461-1916 www. abbott. com. pe

PANTOMUCOL Granulos para suspension oral

BROMHEXINA, CLORHIDRATO DE ERITROMICINA

COMPOSICION

Cada 100 mL de SUSPENSIÓN contienen: Eritromicina etilsuccinato 4 g Bromhexina clorhidrato 80 mg Excipientes c. s. Eritromicina es producida por una cepa de Saccaropolyspora erythraea (Streptomyces arithraeus) y pertenece al grupo macrólido de los antibióticos. Es una sustancia básica que rápidamente forma sales con los ácidos. La base, la sal estearato y los ésteres son pobremente solubles en agua. La bromhexina clorhidrato está químicamente designada como 2-amino-3, 5-dibromo-N-ciclohexil-N-metilbenzenemetanamina monoclorhidrato (C14H21Br2CIN), un polvo cristalino soluble en agua y etanol al 10%. Tiene propiedades mucolíticas y expectorantes.

PROPIEDADES FARMACOLOGICAS

ACCIÓN FARMACOLÓGICA Microbiología: Pruebas bioquímicas han demostrado que la eritromicina inhibe la síntesis de proteína del patógeno sin afectar la síntesis del ácido nucleico. Se ha demostrado antagonismo entre clindamicina y eritromicina. La eritromicina se une a la sub-unidad ribosomal 50S de bacterias susceptibles y suprime la síntesis de proteínas. La eritromicina es usualmente activa sobre la mayoría de cepas de los siguientes organismos in vitro y en infecciones clínicas. . Organismos grampositivos. Corynebacterium diphtheriae . Corynebacterium minutissimum . Listeria monocytogenes . Staphylococcus aureus (durante el tratamiento pueden aparecer organismos resistentes) . Streptococcus pneumoniae . Streptococcus pyogenes . Organismos gramnegativos. Bordetella pertussis . Legionella pneumophilia . Neisseria gonorrhoeae . Otros microorganimos. Chlamydia trachomatis . Entamoeba histolytica . Mycoplasma pneumoniae . Ureaplasma urealyticum La eritromicina ha mostrado ser activa in vitro sobre la mayoría de cepas de los siguientes organismos; sin embargo, la seguridad y eficacia de la eritromicina en el tratamiento de infecciones debido a estos organismos no ha sido establecida en pruebas adecuadas y bien controladas. Organismos grampositivos. Streptococci alpha hemolítico (grupo Viridans) . Organimos gramnegativos. Moraxella (Branhamella) catarrhalis . Otros microorganismos. Entamoeba histolytica . Treponema pallidum Pruebas de susceptibilidad de disco: Métodos cuantitativos que requieren la medición del diámetro dan la más precisa estimación de la susceptibilidad del antibiótico. Un procedimiento recomendado usa discos clase eritromicina para pruebas de susceptibilidad; la interpretación correlaciona el diámetro de la zona obtenida en el disco de prueba con la concentración inhibitoria mínima (CIM) de eritromicina. Con este procedimiento, un reporte de "susceptible" indica que el organismo infectado va a responder a la terapia. Un reporte de "susceptibilidad intermedia" indica que los resultados se consideran equivocados, y, si el patógeno no es completamente susceptible a drogas alternativas clínicamente factibles, la prueba debe ser repetida. Esta categoría provee una zona de tope que previene que pequeños factores técnicos no controlados causen mayor discrepancia en la interpretación. Un reporte de? resistente? indica que el organismo infectado no va a responder a la terapia. Farmacocinética: Eritromicina etilsuccinato, administrada oralmente, es fácilmente absorbida. Se logran niveles séricos óptimos cuando la droga se administra en ayunas o inmediatamente antes de las comidas. Eritromicina se difunde muy bien en la mayoría de fluidos. Solamente se han logrado bajas concentraciones en el fluido espinal, pero el paso de la droga a través de la barrera hemato-encefálica aumenta en caso de meningitis. En la presencia de función hepática normal, la eritromicina se concentra en el hígado y es excretada en la bilis, no se conoce el efecto de la disfunción hepática en la excreción de eritromicina por el hígado a la bilis. Menos del 5% de la dosis oral administrada de eritromicina es excretada en forma activa por la orina. Bromhexina clorhidrato: Estudios clínicos demuestran que la bromhexina aumenta cuantitativamente la secreción bronquial en un 50% más, hasta un máximo de 100%. También ha sido mostrado que produce una reducción cualitativa en la viscosidad del esputo. Comparado con emetina, la acción expectorante de la bromhexina fue más fuerte. A dosis elevadas, se observaron propiedades eméticas, antitusivas y broncoconstrictoras. En pacientes con asma, bromhexina administrada oralmente o por inhalación produjo una rarefacción de los componentes mucopolisacáridos y una disminución en la viscosidad. La acción de la bromhexina fue inhibida por grandes dosis de atropina y se concluyó en que la acción de la bromhexina fue a través de las fibras vagales eferentes.

INDICACIONES

Los productos de combinación de eritromicina bromhexina están indicados en las infecciones del tracto respiratorio superior e inferior originadas por organismos sensibles a la eritromicina y cuando se desea una acción expectorante y mucolítica. Los patógenos comúnmente observados en el tracto respiratorio, sensitivos a la eritromicina incluyen: Streptococcus pyogenes (Grupo A streptococcus beta-hemolítico): Infecciones del tracto respiratorio superior e inferior, infecciones de severidad leve a moderada. Streptococcus pneumoniae (Diplococcus pneumoniae) Infecciones del tracto respiratorio superior (p. ej. otitis media, faringitis) e infecciones del tracto respiratorio inferior (p. ej. neumonía) de grado leve a moderado. Mycoplasma pneumoniae (Agente Eaton, PPLO): Para infecciones respiratorias debido a este organismo. Staphylococcus aureus: Infecciones agudas de severidad leve a moderada. Durante el tratamiento pueden aparecer organismos resistentes. Haemophilus influenzae: Para infecciones del tracto respiratorio superior de severidad leve a moderada. No todas las cepas de este organismo son susceptibles a la eritromicina en concentraciones logradas con la dosis terapéutica usual. Las cepas resistentes pueden requerir terapia concomitante con sulfonamidas. Bordetella pertussis: La eritromicina es efectiva en la eliminación de organismos de la nasofaringe en individuos infectados, convirtiéndolos en no infecciosos. Algunos estudios clínicos han sugerido que la eritromicina puede ser de ayuda en la profilaxis de pertusis en individuos susceptibles expuestos.

CONTRAINDICACIONES Y ADVERTENCIAS

CONTRAINDICACIONES: El uso de la combinación de eritromicina-bromhexina está contraindicado en pacientes con historia previa de hipersensibilidad a la eritromicina o a la bromhexina. La eritromicina está contraindicada en pacientes que toman terfenadina, astemizol, cisaprida, pimozida y ergotamina o dihidroergotamina (ver Precauciones e Interacciones medicamentosas). ADVERTENCIAS: Con la eritromicina se han reportado infrecuentemente disfunción hepática, incluyendo aumento de las enzimas del hígado y hepatitis hepatocelular y/o colestática con o sin ictericia. La colitis pseudomembranosa ha sido reportada con casi todos los agentes antibacteriales, incluyendo macrólidos y puede variar en severidad de leve a fatal. Hubo reportes que sugieren que la eritromicina no alcanza al feto en adecuadas concentraciones para prevenir sífilis congénita. Los niños nacidos de mujeres tratadas durante el embarazo con eritromicina oral por sífilis deben ser tratados con un régimen apropiado de penicilina. Rabdomiólisis con o sin daño renal ha sido reportado en pacientes seriamente enfermos recibiendo eritromicina concomitantemente con lovastatina.

PRECAUCIONES Y ADVERTENCIAS ESPECIALES

PRECAUCIONES General: Eritromicina es excretada principalmente por el hígado. Se debe tener cuidado cuando la eritromicina es administrada a pacientes con daño en la función hepática (ver Farmacologia clínica y Advertencias). El uso prolongado o repetido de eritromicina puede resultar en una sobrepoblación de bacterias u hongos no susceptibles. Si ocurre la superinfección, la eritromicina debe ser descontinuada e instituida una terapia apropiada. Cuando esté indicado, las incisiones y drenajes, u otros procedimientos quirúrgicos deben ser realizados en conjunción con terapia antibiótica. Hubo reportes de que la eritromicina puede agravar la debilidad en pacientes con miastenia gravis. Se han dado reportes de estenosis pilórica hipertrófica infantil (EHPI) en infantes siguiendo terapia de eritromicina. En un corte de 157 recién nacidos que recibieron eritromicina como profilaxis, siete neonatos (5%) desarrollaron síntomas de vómito no bilioso o irritabilidad a los alimentos y fueron diagnosticados subsecuentemente con EHPI requiriendo piloromiotomia quirúrgica. Debido a que la eritromicina puede ser usada en el tratamiento de condiciones asociadas significativamente a mortalidad o morbilidad en infantes (como pertusis o clamidia), el beneficio de la terapia con eritromicina debe ser sopesado contra el riesgo de desarrollar IHPS. Los padres deben estar informados que deben contactar con el medico si ocurre vómito o irritabilidad al alimentarse. Pruebas de laboratorio: Eritromicina interfiere con la determinación fluorométrica de catecolaminas urinarias. Carcinogénesis, mutagénesis, deterioro de la fertilidad: Estudios de largo término (2 años) conducidos en ratas con dosis oral de 400 mg/kg/día y ratones con dosis oral de 500 mg/kg/día con estearato de eritromicina no han dado evidencia de tumorigenicidad. Estudios mutagénicos realizados no demostraron potencial genotóxico, y no hubo efecto aparente sobre la fertilidad en ratas macho o hembras tratadas con eritromicina base por administración oral de 700 mg/kg/día. Embarazo: No hay evidencia de teratogenicidad u otro efecto adverso en la reproducción de ratas hembras a las que se les administró oralmente eritromicina base 350 mg/kg/día (siete veces la dosis humana) antes y durante el apareamiento, durante la gestación y durante el destete. No se observó evidencia de teratogenicidad o embriotoxicidad cuando la eritromicina base fue administrada oralmente a ratas y ratones preñadas a dosis de 700 mg/kg/día (14 veces la dosis humana), y a conejas preñadas con dosis de 125 mg/kg/día (2,5 veces la dosis humana). Se observó una ligera reducción de peso en el peso de las crías de ratas que fueron tratadas antes y después del apareamiento, gestación y lactancia con dosis oral de 700 mg/kg/día de eritromicina base; el peso de los recién nacido fue comprable con aquellos del control en destete. No se evidenció teratogenicidad o efectos sobre la reproducción a esta dosis. Cuando se administra durante la última etapa de la gestación y en el periodo de lactancia, esta dosis de 700 mg/kg/día (14 veces la dosis humana) no dio efectos adversos en el peso al nacer, crecimiento o sobrevivencia de las crías recién nacidas. No hay, sin embargo, estudios adecuados y bien controlados en mujeres embarazadas. Sin embargo, estudios observacionales en humanos han reportado malformaciones cardiovasculares después de la exposición a fármacos con eritromicina durante la etapa inicial del embarazo. Se ha reportado que la eritromicina cruza la barrera placentaria en humanos, pero lo niveles plasmático fetales son generalmente bajos. Eritromicina puede ser usada en mujeres durante el embarazo solo si es claramente necesaria. Labor y parto: Se desconoce el efecto de la eritromicina en labor y parto. Lactancia: Eritromicina es excretada en la leche materna; por ello, se debe tener mucho cuidado cuando la eritromicina es administrada a madres que están dando de lactar. Uso pediátrico: Ver Indicaciones y Dosis y vías de administración.

EFECTOS ADVERSOS

REACCIONES ADVERSAS: Las reacciones adversas más frecuentes de las preparaciones orales de eritromicina son gastrointestinales y están relacionados con la dosis. Incluyen náusea, vómitos, dolor abdominal, diarrea y anorexia. Pueden ocurrir síntomas de hepatitis, disfunción hepática y/o resultados anormales de las pruebas de función del hígado (ver Advertencias). Raramente se ha reportado colitis pseudomembranosa en asociación con la terapia de eritromicina. Hubo reportes aislados de efectos colaterales del Sistema Nervioso Central que incluyen confusión, alucinaciones, mareos, convulsiones, tinnitus y vértigo; sin embargo, una relación causa efecto no ha sido establecida. Como con otros macrólidos, con la eritromicina ha reportado raramente casos de prolongación del intervalo QT, taquicardia ventricular, y torsade de pointes. Reacciones alérgicas desde urticaria, erupciones leves en la piel hasta anafilaxis pueden ocurrir. Reacciones de la piel desde erupciones leves a eritema multiforme, Síndrome de Stevens-Johnson y necrólisis epidermal tóxica han sido raramente reportados. Hubo reportes poco comunes de pancreatitis y convulsiones. Hubo reportes aislados de pérdida de la audición reversible ocurridos principalmente en pacientes con insuficiencia renal y en pacientes que reciben altas dosis de eritromicina. Hubo reportes de nefritis intersticial coincidentes con el uso de eritromicina. Las reacciones adversas reportadas con bromhexina han sido disturbios gastrointestinales leves ocasionales. En pocos pacientes, se han observado elevaciones transitorias de los niveles de transaminasas durante el tratamiento con bromhexina. Estos niveles regresan a la normalidad con la continuación de la terapia con bromhexina.

INTERACCIONES MEDICAMENTOSAS

Eritromicina, usada en pacientes que reciben altas dosis de teofilina, puede ser asociada con el incremento de niveles séricos de teofilina y potencial toxicidad de la misma. En el caso de toxicidad de teofilina y/o elevados niveles séricos de teofilina, la dosis de teofilina debe ser reducida mientras el pacientes está recibiendo terapia concomitante con eritromicina. Se han publicado reportes que sugieren que cuando se da eritromicina con teofilina hay una significativa disminución en las concentraciones séricas de eritromicina. Esto puede resultar en concentraciones subterapéuticas de eritromicina. Se ha reportado que la administración concomitante de eritromicina y digoxina resulta en elevados niveles séricos de digoxina. Hubo reportes de incremento en el efecto anticoagulante cuando se usan concomitantemente eritromicina y anticoagulantes orales. Triazol benzodiazepinas (como triazolam y alprazolam) y benzodiazepinas relacionadas: Ha sido reportado que la eritromicina disminuye la depuración de triazolam, midazolam y benzodiazepinas relacionadas, por ello puede incrementase el efecto farmacológico de estas benzodiazepinas. El uso de eritromicina en pacientes que toman concurrentemente drogas metabolizadas por el citocromo del sistema P450 puede ser asociado con elevaciones en niveles séricos de estas otras drogas. Hubo reportes de interacción de eritromicina con carbamazepina, ciclosporina, hexobarbital, fenitoína, alfentanil, disopiramida, bromocriptina, valproato, tacrolimus, quinidina, metilprednisolona, cilostazol, vinblastina, sildenafil, terfenadina, astemizol y rifabutin. Las concentraciones séricas de las drogas metabolizadas por el sistema citocromo P450 deben ser monitoreadas en pacientes que reciben concurrentemente eritromicina. Inhibidores de la HMG-CoA reductasa: Hay reportes que la eritromicina incrementa las concentraciones de los inhibidotes de la HMG-CoA reductasa (p. ej. lovastatina y simvastatina). Hay reportes raros de rabdomiólisis en pacientes que tomaron eritromicina concomitantemente con lovastatina. Hay reportes posmercadeo de toxicidad por uso concomitante de colchicina y eritromicina. La eritromicina altera significativamente el metabolismo de la terfenadina cuando es tomada concomitantemente. Raros casos de eventos cardiovasculares serios incluyendo muerte, paro cardíaco, torsade de pointes y otras arritmias ventriculares han sido observados (ver Contraindicaciones y Reacciones adversas). La eritromicina altera significativamente el metabolismo de astemizol cuando es tomado concomitantemente. Raros casos de serios efectos adversos cardiovasculares incluyendo paro cardíaco, torsade de pointes y otras arritmias ventriculares han sido observados (ver Contraindicaciones y Reacciones adversas). Se han reportado niveles elevados de cisaprida en pacientes que recibieron eritromicina y cisaprida concomitantemente. Esto puede resultar en intervalos QT prolongados y arritmias cardíacas, incluyendo taquicardia ventricular, fibrilación ventricular y torsade de pointes. Efectos similares han sido observados en pacientes que toman pimozida y claritromicina, otro antibiótico macrólido. Estudios posmercadeo indican que la coadministración de eritromicina y ergotamina o dihidroergotamina ha sido asociada en algunos pacientes con toxicidad por el ergot aguda caracterizada por vasoespasmos e isquemia de las extremidades y otros tejidos incluyendo el Sistema Nervioso Central (ver Contraindicaciones). Se ha reportado que la eritromicina disminuye la depuración de zopiclone y por ello puede incrementar los efectos farmacodinámicos de esta droga.

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Celecoxib Medlineplus Drug Information, Celoxib

Celecoxib

People who take nonsteroidal anti-inflammatory drugs (NSAIDs) (other than aspirin) such as celecoxib may have a higher risk of having a heart attack or a stroke than people who do not take these medications. These events may happen without warning and may cause death. This risk may be higher for people who take NSAIDs for a long time. Do not take an NSAID such as celecoxib if you have recently had a heart attack, unless directed to do so by your doctor. Tell your doctor if you or anyone in your family has or has ever had heart disease, a heart attack, or a stroke, if you smoke, and if you have or have ever had high cholesterol, high blood pressure, or diabetes. Get emergency medical help right away if you experience any of the following symptoms: chest pain, shortness of breath, weakness in one part or side of the body, or slurred speech.

If you will be undergoing a coronary artery bypass graft (CABG; a type of heart surgery), you should not take celecoxib right before or right after the surgery.

NSAIDs such as celecoxib may cause ulcers, bleeding, or holes in the stomach or intestine. These problems may develop at any time during treatment, may happen without warning symptoms, and may cause death. The risk may be higher for people who take NSAIDs for a long time, are older in age, have poor health, or drink large amounts of alcohol while taking celecoxib. Tell your doctor if you drink large amounts of alcohol or if you take any of the following medications: anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); aspirin; other NSAIDs such as ibuprofen (Advil, Motrin) or naproxen (Aleve, Naprosyn); oral steroids such as dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos); selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), fluoxetine (Prozac, Sarafem, Selfemra, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft); or serotonin norepinephrine reuptake inhibitors (SNRIs) such as desvenlafaxine (Khedezla, Pristiq), duloxetine (Cymbalta), and venlafaxine (Effexor XR). Also tell your doctor if you have or have ever had ulcers or bleeding in your stomach or intestines or other bleeding disorders. If you experience any of the following symptoms, stop taking celecoxib and call your doctor: stomach pain, heartburn, vomiting a substance that is bloody or looks like coffee grounds, blood in the stool, or black and tarry stools.

Keep all appointments with your doctor and the laboratory. Your doctor will monitor your symptoms carefully and will probably order certain tests to check your body's response to celecoxib. Be sure to tell your doctor how you are feeling so that your doctor can prescribe the right amount of medication to treat your condition with the lowest risk of serious side effects.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with celecoxib and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www. fda. gov/Drugs/DrugSafety/ucm085729.htm ) or the manufacturer's website to obtain the Medication Guide.

Why is this medication prescribed?

Celecoxib is used to relieve pain, tenderness, swelling and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints), rheumatoid arthritis (arthritis caused by swelling of the lining of the joints), and ankylosing spondylitis (arthritis that mainly affects the spine). It is also used to treat juvenile rheumatoid arthritis (a type of arthritis that affects children) in children 2 years of age and older. Celecoxib is also used to treat painful menstrual periods and to relieve other types of short-term pain including pain caused by injuries, surgery and other medical or dental procedures, or medical conditions that last for a limited time. Celecoxib is in a class of NSAIDs called COX-2 inhibitors. It works by stopping the body's production of a substance that causes pain and inflammation.

How should this medicine be used?

Celecoxib comes as a capsule to take by mouth. It is usually taken once or twice a day. If you are taking up to 200 mg of celecoxib at a time, you may take the medication with or without food. If you are taking more than 200 mg of celecoxib at a time, you should take the medication with food. Ask your doctor or pharmacist if you are not sure if you need to take your medication with food. To help you remember to take celecoxib, take it around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take celecoxib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

If you cannot swallow the capsules or if you are giving this medication to a child, you may open the capsules and sprinkle the contents over a teaspoon of cold or room temperature applesauce. You may prepare the mixture in advance and store it for up to 6 hours in a refrigerator. When you are ready to take your medication, swallow all of the mixture. Then drink water to wash down the mixture and be sure that you have swallowed all of it.

Other uses for this medicine

Celecoxib is also sometimes used with surgery and other treatments to reduce the number of polyps (abnormal growths) in the colon (large intestine) and rectum in patients with familial adenomatous polyposis (a condition in which hundreds or thousands of polyps form in the colon and cancer may develop). Talk to your doctor about the risks of using this medication for your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking celecoxib,

tell your doctor and pharmacist if you are allergic to celecoxib, aspirin or other NSAIDs such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn), sulfa medications, any other medications, or any of the inactive ingredients in celecoxib capsules. Ask your pharmacist for a list of the inactive ingredients.

tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin, in Lotrel), captopril, enalapril (Vasotec, in Vaseretic), fosinopril, lisinopril (in Zestoretic), moexipril (Univasc), perindopril (Aceon, in Prestalia), quinapril (Accupril, in Quinaretic), ramipril (Altace), and trandolapril (Mavik, in Tarka); angiotensin receptor blockers such as candesartan (Atacand, in Atacand HCT), eprosartan (Teveten), irbesartan (Avapro, in Avalide), losartan (Cozaar, in Hyzaar), olmesartan (Benicar, in Azor, in Benicar HCT, in Tribenzor), telmisartan (Micardis, in Micardis HCT, in Twynsta), and valsartan (in Exforge HCT); beta blockers such as atenolol (Tenormin, in Tenoretic), labetalol (Trandate), metoprolol (Lopressor, Toprol XL, in Dutoprol), nadolol (Corgard, in Corzide), and propranolol (Hemangeol, Inderal, Innopran); diuretics ('water pills'); fluconazole (Diflucan); and lithium (Lithobid). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

tell your doctor if you have or have ever had any of the conditions mentioned in the IMPORTANT WARNING section or asthma, especially if you also have frequent stuffed or runny nose or nasal polyps (swelling of the lining of the nose); swelling of the hands, arms, feet, ankles, or lower legs; heart failure; or liver or kidney disease.

tell your doctor if you are pregnant, especially if you are in the last few months of your pregnancy, you plan to become pregnant, or you are breast-feeding. If you become pregnant while taking celecoxib, call your doctor.

if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking celecoxib.

What special dietary instructions should I follow?

Celecoxib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

diarrhea

gas or bloating

sore throat

cold symptoms

Some side effects can be serious. If you experience any of the following symptoms or those mentioned in the IMPORTANT WARNING section, call your doctor immediately. Do not take any more celecoxib until you speak to your doctor.

unexplained weight gain

shortness of breath or difficulty breathing

swelling of the abdomen, feet, ankles, or lower legs

nausea

excessive tiredness

unusual bleeding or bruising

itching

lack of energy

loss of appetite

pain in the upper right part of the stomach

yellowing of the skin or eyes

flu-like symptoms

blisters

fever

rash

hives

swelling of the face, throat, tongue, lips, eyes, or hands

hoarseness

difficulty swallowing or breathing

pale skin

fast heartbeat

cloudy, discolored, or bloody urine

back pain

difficult or painful urination

frequent urination, especially at night

Celecoxib may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www. fda. gov/Safety/MedWatch ) or by phone (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo. gl/c4Rm4p ) for more information if you do not have access to a take-back program.

In case of emergency/overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Symptoms of overdose may include:

lack of energy

drowsiness

nausea

vomiting

stomach pain

vomiting material that is bloody or looks like coffee grounds

bloody or black, tarry stools

loss of consciousness

hives

rash

swelling of the eyes, face, tongue, lips, throat, arms, hands, feet, ankles, or lower legs

difficulty breathing or swallowing

What other information should I know?

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

Your blood pressure should be checked regularly during your treatment.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand names

Mental Health Information What Are Topirol Uses And Side Effects, Topirol

Topirol is a medication manufactured by Sun pharmaceutical company, India. Its Generic Name is Topiramate.

Topirol is a medication prescribed for epilepsy and prevention of migraine. This drug is also used as a mood stabilizer in certain hospitals. One of the main problems with this drug is increased risk of suicide and angle closure gluocoma (increased pressure in the eye).

Topirol 50mg Tablets

Topirol blocks voltage dependant sodium channels, increase the activity of GABA, blocks NMDA receptors and inhibits the enzyme carbonic anhydrase. These effects decreases nerve impulse transmission and prevent seizures.

This medication is available as tablets. Tablets should be taken as a whole without crushing and should be taken with a full glass of water to minimize side effects. Patients should drink enough water during the therapy as well. Otherwise this medication is known to cause kidney stones. Topirol should be taken exactly as directed by the doctor. Abrupt withdrawal of this drug can have problems. Patient should not take alcoholic beverages during therapy.

Use in epilepsy

This medication is prescribed for partial and generalized epilepsies. In partial epilepsy patient gets a seizure in a part of the body. In generalized epilepsy, patients whole body is involved in the seizure. This medication can be combined with other seizure medications like sodium valproate. It is used in adults as well in children.

Use in migraine

This medication is prescribed for long term prevention of migraine attacks. Several studies have demonstrated its effectiveness in this condition. But Topirol cannot be used to treat a migraine attack. Some psychiatrists use this drug in bipolar affective disorder to stabilize the patients mood. But no proper clinical trials have been conducted so far, in this regard.

The doctor needs patient’s complete medical history including over the counter medications he/she is taking, before prescribing Topiramate. If the patient is having kidney problems or liver problems it is very important to discuss that with the doctor, before taking Topiramate. If the patient is pregnant or planning to get pregnant, then the patient should discuss that with the doctor as well. The doctor should know whether the patient is having any psychiatric illnesses including depression. This medication can increase the risk of suicide in susceptible individuals.

In addition, Topirol is used in treatment of alcohol dependence as an anti craving medication.

Common side effects One of the main side effect of Topirol is cognitive impairment. It can cause learning disability in children. Nausea, gastric irritation, diarrhea and dry mouth are the commonest side effects. Some patients can get taste disturbance, weight loss and loss of appetite. This medication does not cause weight gain, unlike other antiepileptic drugs. This medication also causes headache and numbness. This medication also causes drowsiness, fatigue, sleep disturbances, impaired memory and concentration.

Very rarely this medication can cause reduced sweating in children. This medication secretes into the breast milk. So this drug should not be taken in breast feeding.

Sources British National Formulary AHFS Drug information

About Dr. Manura Nanayakkara

Manura Nanayakkara

Dr. Manura Nanayakkara is a Medical doctor working in Sri Lanka. He graduated from the Faculty of Medicine University of Colombo in 2005. In addition to his undergraduate medical degree, he holds a Postgraduate Diploma in Psychiatry. He completed his postgraduate degree in 2011. 

He started to work as a medical internist in the District general Hospital Nawalapitiya in the Kandy district (central Sri Lanka) in 2006. Following his basic training, he started to work in a Rural hospital in Akuressa (Southern part of Sri Lanka). During that period he used to treat wide variety of diseases in this rural community.

Due to his interest in the field of Psychiatry, he entered into the Diploma in Psychiatry course conducted by the Postgraduate Institute of Medicine, University of Colombo. It is the only Postgraduate medical institute in Sri Lanka.

Zmax (Azithromycin) Side Effects, Interactions, Warning, Dosage & Uses, Zimax

DRUG DESCRIPTION

Zmax (azithromycin extended-release) for oral suspension contains the active ingredient azithromycin (as azithromycin dihydrate), an azalide, a subclass of macrolide antibacterial drug. Azithromycin has the chemical name (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)13-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyra nosyl) oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)β-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one. Azithromycin is derived from erythromycin ; however, it differs chemically from erythromycin in that a methyl-substituted nitrogen atom is incorporated into the lactone ring. Its molecular formula is C 38 H 72 N 2 O 12 . and its molecular weight is 749.0. Azithromycin has the following structural formula:

Azithromycin, as the dihydrate, is a white crystalline powder with a molecular formula of C 38 H 72 N 2 O 12 •2H 2 O and a molecular weight of 785.0.

Zmax is a single-dose, extended-release formulation of microspheres for oral suspension containing azithromycin (as azithromycin dihydrate) and the following excipients: glyceryl behenate, poloxamer 407, sucrose, sodium phosphate tribasic anhydrous, magnesium hydroxide, hydroxypropyl cellulose, xanthan gum, colloidal silicon dioxide, titanium dioxide, artificial cherry flavor, and artificial banana flavor.

Note: Each bottle of Zmax 2 g for oral suspension contains approximately 148 mg of sodium and 19 g of sucrose. Constituted Zmax oral suspension contains approximately 2 mg/mL of sodium and 0.26 g/mL of sucrose.

What are the possible side effects of azithromycin?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using azithromycin and call your doctor at once if you have a serious side effect such as:

diarrhea that is watery or bloody;

headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats;

nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or

severe skin reaction -- fever, sore throat.

What are the precautions when taking azithromycin (Zmax)?

Before taking azithromycin, tell your doctor or pharmacist if you are allergic to it; or to other antibiotics (such as erythromycin, clarithromycin, telithromycin); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, a certain muscle disease (myasthenia gravis).

Azithromycin may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can infrequently result in serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right.

Last reviewed on RxList: 6/7/2016 This monograph has been modified to include the generic and brand name in many instances.

Duoneb Dosage Guide, Duoneb

DuoNeb Dosage

The information at Drugs. com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

The recommended dose of Ipratropium Bromide and Albuterol Sulfate Inhalation Solution is one 3 mL vial administered 4 times per day via nebulization with up to 2 additional 3 mL doses allowed per day, if needed. Safety and efficacy of additional doses or increased frequency of administration of Ipratropium Bromide and Albuterol Sulfate Inhalation Solution beyond these guidelines has not been studied and the safety and efficacy of extra doses of albuterol sulfate or ipratropium bromide in addition to the recommended doses of Ipratropium Bromide and Albuterol Sulfate Inhalation Solution have not been studied.

The use of Ipratropium Bromide and Albuterol Sulfate Inhalation Solution can be continued as medically indicated to control recurring bouts of bronchospasm. If a previously effective regimen fails to provide the usual relief, medical advice should be sought immediately, as this is often a sign of worsening COPD, which would require reassessment of therapy.

A Pari-LC-Plus™ nebulizer (with face mask or mouthpiece) connected to a PRONEB™ compressor was used to deliver Ipratropium Bromide and Albuterol Sulfate Inhalation Solution to each patient in one U. S. clinical study. The safety and efficacy of Ipratropium Bromide and Albuterol Sulfate Inhalation Solution delivered by other nebulizers and compressors have not been established.

Ipratropium Bromide and Albuterol Sulfate Inhalation Solution should be administered via jet nebulizer connected to an air compressor with an adequate air flow, equipped with a mouthpiece or suitable face mask.

Terazoflo, Terazoflo

Gastrointestinal - Terazoflo (Brand name: hytrin)

Hytrin is used for treating high blood pressure and treating signs and symptoms of benign prostatic hyperplasia (BPH). Hytrin is an alpha-blocker. It works by relaxing muscles in the blood vessels, resulting in lowering of blood pressure. In BPH, alpha-blockers work by relaxing muscles around the urethra (tube that drains urine from the bladder), which improves urinary symptoms.

Use Hytrin as directed by your doctor.

Take Hytrin by mouth with or without food.

Hytrin may cause a sudden drop in blood pressure after the first dose. Take your first dose at bedtime. If you get up during the night, sit up slowly, then stand slowly.

If you miss a dose of Hytrin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. If more than one dose is missed, contact your doctor or pharmacist.

Ask your health care provider any questions you may have about how to use Hytrin.

Store Hytrin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Hytrin out of the reach of children and away from pets.

Active Ingredient: Terazosin hydrochloride.

Do NOT use Hytrin if:

you are allergic to any ingredient in Hytrin or to similar medicines (eg, prazosin).

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Hytrin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have prostate cancer, angina pectoris, heart disease, or kidney or liver problems

if you will be having eye surgery.

Some medicines may interact with Hytrin. Tell your health care provider if you are taking any other medicines, especially any of the following:

Phosphodiesterase type 5 (PDE5) inhibitors (eg, sildenafil) or verapamil because severe dizziness, lightheadedness, or fainting may occur.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Hytrin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Hytrin may cause drowsiness, dizziness, blurred vision, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Hytrin with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Hytrin; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.

Hytrin may cause a sudden drop in blood pressure after the first dose. Take your first dose at bedtime. If you get up during the night, sit up slowly, then stand slowly. This will help to reduce your lightheadedness or dizziness. These effects are more likely to occur after the first few doses or if your dose has increased, but can occur at any time while you are taking the medicine. It can also occur if you stop taking the medicine and then restart treatment.

Hytrin may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.

Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.

Do NOT take more than the recommended dose without checking with your doctor.

Hytrin may rarely cause a prolonged, painful erection. This could happen even when you are not having sex. If this is not treated right away, it could lead to permanent sexual problems such as impotence. Contact your doctor right away if this happens.

Tell your doctor or dentist that you take Hytrin before you receive any medical or dental care, emergency care, or surgery (including eye surgery).

Lab tests, including blood pressure, may be performed while you use Hytrin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Hytrin should not be used in children; safety and effectiveness in children have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Hytrin while you are pregnant. It is not known if Hytrin is found in breast milk. If you are or will be breast-feeding while you use Hytrin, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Dizziness; drowsiness; lightheadedness; nasal congestion; nausea; weakness.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision or other vision changes; chest pain; decreased sexual desire or ability; fainting; fast, slow, or irregular heartbeat;painful, prolonged erection; severe or prolonged dizziness or headache; shortness of breath; swelling of the ankles, feet, or hands.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Mobic Uses, Dosage - Side Effects, Moxic

Mobic

What is Mobic?

Mobic (meloxicam) is a nonsteroidal anti-inflammatory drug (NSAID). Meloxicam works by reducing hormones that cause inflammation and pain in the body.

Mobic is used to treat pain or inflammation caused by rheumatoid arthritis and osteoarthritis in adults. Mobic is also used to treat juvenile rheumatoid arthritis in children who are at least 2 years old.

Mobic may also be used for purposes not listed in this medication guide.

Important information

Mobic can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Get emergency medical help if you have chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance.

Mobic may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using Mobic, especially in older adults.

Call your doctor at once if you have symptoms of stomach bleeding such as black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds.

Avoid drinking alcohol. It may increase your risk of stomach bleeding.

Ask a doctor or pharmacist before using any other cold, allergy, or pain medicine. Medicines similar to meloxicam are contained in many combination medicines. Check the label to see if a medicine contains an NSAID (non-steroidal anti-inflammatory drug) such as aspirin, ibuprofen, ketoprofen, or naproxen.

Mobic can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease. Even people without heart disease or risk factors could have a stroke or heart attack while taking this medicine.

Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Mobic may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using Mobic, especially in older adults.

You should not use Mobic if you are allergic to meloxicam, or if you have ever had an asthma attack or severe allergic reaction after taking aspirin or an NSAID.

To make sure Mobic is safe for you, tell your doctor if you have:

heart disease, high blood pressure, high cholesterol, diabetes, or if you smoke;

a history of heart attack, stroke, or blood clot;

a history of stomach ulcers or bleeding;

kidney disease (or if you are on dialysis);

liver disease; or

Taking Mobic during the last 3 months of pregnancy may harm the unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Mobic may cause a delay in ovulation (the release of an egg from an ovary). You should not take Mobic if you are undergoing fertility treatment, or are otherwise trying to get pregnant.

Meloxicam can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.

Mobic is not approved for use by anyone younger than 2 years old.

How should I take Mobic?

Take Mobic exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger amounts or for longer than recommended. Use the lowest dose that is effective in treating your condition.

You may take Mobic with or without food.

Shake the oral suspension (liquid) well just before you measure a dose. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

If a child is taking this medication, tell your doctor if the child has any changes in weight. Mobic doses are based on weight in children.

If you use this medicine long-term, you may need frequent medical tests.

Store Mobic at room temperature, away from moisture and heat. Keep the bottle tightly closed when not in use.

Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Mobic?

Avoid drinking alcohol. It may increase your risk of stomach bleeding.

Avoid taking aspirin while you are taking Mobic.

Ask a doctor or pharmacist before using any cold, allergy, or pain medication. Many medicines available over the counter contain aspirin or other medicines similar to Mobic. Taking certain products together can cause you to get too much of this type of medication. Check the label to see if a medicine contains aspirin, ibuprofen, ketoprofen, or naproxen.

Mobic side effects

Get emergency medical help if you have signs of an allergic reaction to Mobic: sneezing, runny or stuffy nose; wheezing or trouble breathing; hives; swelling of your face, lips, tongue, or throat.

Get emergency medical help if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, feeling short of breath.

Stop using Mobic and call your doctor at once if you have:

the first sign of any skin rash, no matter how mild;

shortness of breath (even with mild exertion);

swelling or rapid weight gain;

signs of stomach bleeding - bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;

liver problems - nausea, upper stomach pain, itching, tired feeling, flu-like symptoms, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

kidney problems - little or no urinating, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath;

low red blood cells (anemia) - pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating; or

severe skin reaction - fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Common Mobic side effects may include:

upset stomach, nausea, vomiting, heartburn;

diarrhea, constipation, gas;

cold symptoms, flu symptoms.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Mobic dosing information

Usual Adult Dose of Mobic for Osteoarthritis:

Initial dose: 7.5 mg orally once daily Maintenance dose: 7.5 mg orally once daily Maximum dose: 15 mg orally daily

Usual Adult Dose for Rheumatoid Arthritis:

Initial dose: 7.5 mg orally once daily Maintenance dose: 7.5 mg orally once daily Maximum dose: 15 mg orally daily

Usual Pediatric Dose for Juvenile Rheumatoid Arthritis:

Greater than or equal to 2 years: 0.125 mg/kg orally once daily

Maximum dose: 7.5 mg orally daily

There was no additional benefit demonstrated by increasing the dose above 0.125 mg/kg once daily in clinical trials.

What other drugs will affect Mobic?

Ask your doctor before using Mobic if you take an antidepressant such as citalopram, escitalopram, fluoxetine (Prozac), fluvoxamine, paroxetine, sertraline (Zoloft), trazodone, or vilazodone. Taking any of these medicines with an NSAID may cause you to bruise or bleed easily.

Tell your doctor about all your current medicines and any you start or stop using, especially:

sodium polystyrene sulfonate (Kayexalate);

a blood thinner (warfarin, Coumadin, Jantoven);

heart or blood pressure medication, including a diuretic or "water pill"; or

steroid medicine (such as prednisone).

This list is not complete. Other drugs may interact with meloxicam, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

More about Mobic (meloxicam)

Consumer resources

Professional resources

Related treatment guides

Where can I get more information?

Your pharmacist can provide more information about Mobic.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Mobic only for the indication prescribed.

Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2016 Cerner Multum, Inc. Version: 12.03. Revision Date: 2015-12-04, 11:20:16 AM.

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