Diflucan - Anti Fungal, Canifug Fluco

Product Description Common use Diflucan is an anti-fungal antibiotic which is used to treat fungal infections called candidiasis. This medication is prescribed for the treatment of such type of infections as vaginal, throat and fungal infections, infections of the urinary tract, peritonitis, and pneumonia. Diflucan works by killing sensitive fungi by interfering with the formation of the fungal cell membrane.

Dosage and direction Take it orally once a day, with or without food using the measuring spoon. Take it at the same time each day with a full glass of water if you want to get the best result. Diflucan make you feel better after 24 hours. However, your symptoms will go away completely just after few days. If there is no change in your health after a few days consult your doctor immediately. The dosage for adults may vary from type of infection: 1) Genital thrush - 150mg as a single dose 2) Mucosal thrush - dose depends on where the infection is located 50mg once daily during month. 3)Fungal skin infections - 50mg once daily for 2-4 weeks ; 4) Internal fungal infections 400mg on the first day then 200-400mg once daily for 6-8 weeks or longer if needed. 5) To stop you from getting fungal infections - 50-400mg once daily while you have risk to get an infection; 6) To stop infection caused by Cryptococcus from coming back - 100-200mg once daily indefinitely The dosage for children 4 weeks to 15 years old may also vary from type of infection: 1) mucosal infections - 3mg/kg once daily; 2)internal fungal infections - 6-12mg/kg once daily; 3)prevention of fungal infections - 3-12mg/kg once daily while at risk of getting an infection. For children 2-4 weeks old it is same dose as above but given once every 2 days. A maximum dose of 12mg/kg every 2 days. For children less than 2 weeks old it is same dose as above but given once every 3 days. Do not give more then 12mg/kg every 3 days. Note: this instruction presented here is just for review. It's very necessary to consult your doctor before using. It will help you to get best results.

For vaginal yeast infections, doctors usually prescribe a single dose of Diflucan. If the yeast infection does not improve after 5 days, contact your doctor as soon as possible. Be careful with this medication if your medical history include liver disease or kidney disease. Although uncommon, this drug may make you dizzy, so be more attentive while you are driving or using machinery. Limit alcohol intake. Diflucan should not be used during pregnancy, lactation or if you plan to become pregnant without a doctor's advice. Do not use before breast-feeding without a doctor's advice.

Contraindications Diflucan is not allowed to people who have hypersensitivity to Fluconazole or other anti fungal azole preparations, eg clotrimazole, ketoconazole, itraconazole and other. Also Diflucan contraindicated in: Kidney and liver disorders; Cardiovascular diseases including heart diseases(heart rate or rhythm disturbances); Low blood levels of calcium, magnesium or potassium.

Possible side effect

They may include an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Also the most possible side effects include: nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); fever, chills, body aches, flu symptoms; severe blistering, peeling, and red skin rash; easy bruising or bleeding, unusual weakness; or seizure (convulsions). Less serious include: mild nausea, vomiting, diarrhea, or upset stomach; headache; dizziness; unusual or unpleasant taste in your mouth; or skin rash or itching. If you experience one of them stop using Diflucan and tell your doctor as soon as possible. Also consult your doctor about any side effect that seems unusual.

Drug interaction Diflucan interact with such medication as: a blood thinner such as warfarin (Coumadin) cyclosporine (Gengraf, Sandimmune, Neoral); an oral diabetes medicine such as glipizide (Glucotrol), glyburide (Diabeta, Micronase, Glynase), tolbutamide (Orinase), tolazamide (Tolinase), chlorpropamide (Diabinese), and others; rifabutin (Mycobutin) or rifampin (Rifadin, Rifater, Rifamate, Rimactane); a sedative such as diazepam (Valium), lorazepam (Ativan), alprazolam (Xanax), or midazolam (Versed); seizure medication such as phenytoin (Dilantin) or valproic acid (Depakene); tacrolimus ((Prograf); theophylline (Theo-Dur, Theolair, Theochron, Elixophyllin, Slo-Phyllin, others). Also note that interaction between two medications does not always mean that you must stop taking one of them. Usually it affects the the effect of drugs, so consult your doctor about the way these interactions are being managed or should be managed.

Missed dose If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not take double or extra doses. Take your usual dose next day in the same time.

Overdose Symptoms of Diflucan overdose may include: confusion or unusual thoughts or behavior. If you experience one of them call your doctor immediately.

Storage Store at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture, kids and pets. Do not use after expiration term.

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Lotivas, Lotivas

Lovastatin

Click for further information on drug naming conventions and International Nonproprietary Names .

Important Notice: The Drugs. com international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

Lotivas

Important Notice: The Drugs. com international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

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Linatil Comp - Pills Blog, Dynacil Comp

Description

Hydrochlorothiazide is used for treating high blood pressure.

Hydrochlorothiazide (Linatil comp) as known as: Acesistem, Acortiz, Acuren, Adelphan, Aldoril, Altace hct, Amiloretic, Ampril hd, Angiozide, Aquazide, Aratan-d, Belsar plus, Benalapril plus, Benazeplus, Berlipril, Beta-turfa, Bifril plus, Bifrizide, Bihasal, Bisobeta comp, Bisocombin, Bisohexal plus, Bisolich comp, Bisoplus, Bisostad plus, Bitensil diu, Blopress plus, Bpzide, Briazide, Bumeftyl, Byol, Capto-corax comp, Capto-isis plus, Captobeta comp, Captogamma hct, Captosol comp, Cardace comp, Cesplon plus, Cibadrex, Cilazil, Clorana, Co aprovel, Co diovan forte, Co renitec, Co-amilozide, Co-enac hexal, Co-enalapril, Co-enatec, Co-epril, Co-inhibace, Co-lisinopril, Co-lisinostad, Co-mepril, Co-quinapril, Co-renistad, Co-renitec, Co-reniten, Coepratenz plus, Comilorid-mepha, Concor plus, Condiuren, Cordinate plus, Corodil comp, Corodin d, Corvo hct, Cosaar, Coteveten, Crinoretic, Dehydratin, Dehydratin neo, Di-ertride, Di-eudrin, Dichlotride, Diclotride, Dilabar diu, Disalunil, Disothiazide, Disys plus, Ditenside, Dithiazide, Diu venostasin, Diunorm, Diur, Diurace, Diuretidin, Diuretikum verla, Do-hydro, Dociteren, Drenol, Duopril, Duradiuret, Dynacil comp, Dynorm plus, Dytenzide, Dytide, Ednyt hct, Elektra, Elpradil hct, Emconcor comp, Emcoretic, Emestar plus, Enacecor, Enacomi, Enahexal comp, Enala-q comp, Enalagamma hct, Enalich comp, Enap-co, Enaplus, Enulid 15, Epratenz, Epratenzide plus, Epril plus, Eprosartan, Eprotan, Esidrex, Esidrix, Femipres plus, Fempress plus, Fosicard plus, Fosicomb, Fosicombi, Fosicomp, Fosinopril, Fosinorm comp, Fositens plus, Fozide, Foziretic, Futuran plus, Gamathiazid, Gentipress, Gliotenzide, Herten plus, Hexal-lisinopril, Hexazide, Hidroclorotiazida, Hidroronol, Hidrosaluretil, Hidrotiadol, Hiperlex plus, Hipoartel plus, Hydra-zide, Hydrene, Hydrex, Hydrodiuril, Hydromet, Hydrozide, Hypodehydra, Hypothiazid, Inderide, Inhibace, Inibace plus, Initiss plus, Inocar plus, Iperton, Irtan plus, Isoptin rr plus, Ixia plus, Kalpress plus, Konveril plus, Labodrex, Lidaltrin diu, Linatil comp, Lisi tad hct, Lisi-puren comp, Lisibeta comp, Lisigamma hct, Lisihexal comp, Lisiplus, Lisoretic, Lispirl, Lodoz, Logroton retard, Loortan plus, Loren-press, Lorzaar, Losapot-h, Losar-q comp, Losar-tevacomp, Losargamma hct, Losarplus al, Losartas ht, Losatan hz, Losatrix comp, Losavik-h, Lotrial d, Maxsoten, Medozide, Mencord plus, Meramyl hct, Meto-succinat hct, Metobeta comp, Metodura comp, Metohexal comp, Metostad comp, Microzide, Miten plus, Modrex, Monoplus, Monopril, Monozide, Navixen plus, Nefrix, Neo lotan plus, Neoprex, Neotensin diu, Nephral, Newtolide, Nolarmin, Normolose-h, Nu-triazide, Olina, Olinapril h, Olmax-h, Openvas plus, Oretic, Pantemon, Parapres plus, Pharmapress co, Pressitan plus, Prestole, Pritor plus, Propra, Quinaplus, Quinaretic, Quiril comp, Ramasar hct, Rasilez hct, Regulaten plus, Renacor, Renapril plus, Renezide, Renil hct, Reniten plus, Rethizid, Ridaq, Rofucal, Sarilen plus, Sarteg hct, Sectrazide, Selokomb, Synerpril, Tandiur, Tekturna hct, Tevafos, Tevanap, Tevetec, Teveten plus, Tevetens plus, Tiaren, Tiazid, Timolide, Tri-thiazid, Triamizide, Triampur, Triamtereen, Triamteril, Triastad hct, Triatec comp, Triniton, Tritace comp, Tritace hct, Turfa, Uniretic, Urirex k, Vaseretic, Votum plus, Wytens, Zaprace-d, Zapto-co, Ziak, Zofenil diu, Zofenil plus, Zofenilduo, Zok-zid, Zopranol diu, Zoprazide

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Linatil Side Effects

Linatil Side Effects Track Your Side Effects

Note Your Observations

It is really important to keep track of your health symptoms, right from the time you start a new medicine. You can do it any way you prefer: in a notebook, in a computer file or using our online tool. You should also note down any other medicines you are taking at the same time, because there could be an interaction between these medicines.

Why Your Notes are Important

Your notes could be helpful in several ways:

You can use them to remind you of details that may alert your health care professional(s) to a problem

You will have a record to refer to in the future, in case you are ever prescribed the same medicine again

You can use the following log form to write down important information, like the date and time you experienced a side effect and your symptoms, how strong the symptoms were, and any other medicines you were using.

Medicine Name and Dosage:

Other Medicine(s) or Treatment(s)

Scale: 1 = very mild to 10 = very bad

Side effects reports are analyzed to discover potential health product safety signals. Some important reactions may take an extremely long time to develop or occur infrequently. Continued monitoring of adverse reactions is thus essential to maintain a comprehensive safety and effectiveness profile of health products.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Linatil reports list potential signals of serious risks and new safety information that were identified using the FDA Adverse Event Reporting System (FAERS). FAERS is a database that contains information on adverse event and medication errors reports submitted to FDA by healthcare professionals (such as physicians, pharmacists, nurses and others), consumers (such as patients, family members, layers and others) and manufacturers.

Discuss Linatil Side Effects Did You Have a Linatil Side Effect? View Results How Effective is Linatil for You? View Results Linatil Safety Alerts, Active Ingredients, Usage Information

Side Effects reported to FDA: 5

Linatil safety alerts: No

Reported deaths: 1

Reported hospitalizations: 1

No reviews, be a first to report a side effect via side effect reporting form

© 2006-2016 PatientsVille. com

Notice - The material on this site is for informational purposes only, and is not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider. Viewing and using of this information is subject to accepting Terms Of Use. PatientsVille. com does not provide medical advice, diagnosis or treatment. The information regarding adverse reports, reviews and polls contained on PatientsVille. com site has not been scientifically or otherwise verified as to a cause and effect relationship and cannot be used to estimate the incidence of side effects, adverse drug reactions or for establishing or changing of patient treatments. Thank you for visiting Patientsville. com!

Linatil - search results

Marketed by: Hexal A/S Other information: Tablett - 20 mg/12,5 mg

rekommenderas inte nar du tar Linatil comp. Linatil comp rekommenderas vanligen inte. sarskild forsiktiga med anvandning av Linatil comp. Linatil comp kan vara mindre. magnesiumstearat. Lakemedlets utseende och forpackningsstorlekar Linatil comp 20 mg/12,5 mg.

Available in: Sweden Language: Swedish Source: Läkemedelsverket / Medical Products Agency - Sweden

Marketed by: Hexal A/S Other information: Tablett - 20 mg/6 mg

forsiktiga med anvandning av Linatil comp mite. Linatil comp mite kan vara. talk. Lakemedlets utseende och forpackningsstorlekar Linatil comp mite tabletter ar vita. som ar forpackad i kartong. Linatil comp mite tabletterna finns i forpackningsstorlekar.

Available in: Sweden Language: Swedish Source: Läkemedelsverket / Medical Products Agency - Sweden

Marketed by: HEXAL A/S Active ingredient: Enalaprili maleas Other information: tabletti - 10 mg

PAKKAUSSELOSTE Linatil 2,5 mg tabletti Linatil 5 mg tabletti Linatil 10 mg tabletti Linatil 20 mg tabletti. ett annat lakemedel istallet for Linatil . Linatil rekommenderas inte i borjan av graviditeten.

Available in: Finland Language: Finnish Source: Fimea

Marketed by: HEXAL A/S Active ingredient: Enalaprili maleas Other information: tabletti - 5 mg

PAKKAUSSELOSTE Linatil 2,5 mg tabletti Linatil 5 mg tabletti Linatil 10 mg tabletti Linatil 20 mg tabletti. ett annat lakemedel istallet for Linatil . Linatil rekommenderas inte i borjan av graviditeten.

Available in: Finland Language: Finnish Source: Fimea

Marketed by: HEXAL A/S Active ingredient: Enalaprili maleas Other information: tabletti - 20 mg

PAKKAUSSELOSTE Linatil 2,5 mg tabletti Linatil 5 mg tabletti Linatil 10 mg tabletti Linatil 20 mg tabletti. ett annat lakemedel istallet for Linatil . Linatil rekommenderas inte i borjan av graviditeten.

Available in: Finland Language: Finnish Source: Fimea

Marketed by: HEXAL A/S Active ingredient: Enalaprili maleas Other information: tabletti - 2.5 mg

PAKKAUSSELOSTE Linatil 2,5 mg tabletti Linatil 5 mg tabletti Linatil 10 mg tabletti Linatil 20 mg tabletti. ett annat lakemedel istallet for Linatil . Linatil rekommenderas inte i borjan av graviditeten.

Available in: Finland Language: Finnish Source: Fimea

Marketed by: GEA Farmaceutisk Fabrik AS Active ingredient: Enalaprilmaleat Other information: Tablett - 2,5 mg

Available in: Norway Language: Norwegian Bokmal Source: NMA

Marketed by: Hexal A/S Active ingredient: Enalaprili maleas, Hydrochlorothiazidum Other information: tabletti - 20 mg / 12.5 mg

korkean verenpaineen hoitoon. (FI, LINATIL HEXAL COMP) Enalapril maleate/. Jos tulet raskaaksi Linatil hexal (FI, LINATIL HEXAL COMP) Enalapril. Alkoholi. Laakkeet, jotka saattavat heikentaa Linatil hexal Comp valmisteen vaikutusta: Kolestyramiini.

Available in: Finland Language: Finnish Source: Fimea

Marketed by: HEXAL A/S Active ingredient: Enalaprili maleas Other information: tablet - 5 mg

Available in: Finland Language: English Source: Fimea

Marketed by: GEA Farmaceutisk Fabrik AS Active ingredient: Enalaprilmaleat Other information: Tablett - 2,5 mg

Available in: Norway Language: Norwegian Bokmal Source: NMA

Linatil comp

Product description

Safety information

Side effects

Hydrochlorothiazide is used for treating high blood pressure. It is also used to treat fluid buildup in the body caused by certain conditions (eg, heart failure, liver cirrhosis, kidney problems) or medicines (eg, corticosteroids, estrogen). It may be used alone or with other medicines. Hydrochlorothiazide is a thiazide diuretic. It helps the kidneys to remove fluid from the body.

Use Hydrochlorothiazide as directed by your doctor.

Take Hydrochlorothiazide by mouth with or without food.

Hydrochlorothiazide may increase the amount of urine or cause you to urinate more often when you first start taking it. To keep this from disturbing your sleep, try to take your dose before 6 pm.

If you miss a dose of Hydrochlorothiazide, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Hydrochlorothiazide.

Store Hydrochlorothiazide at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Hydrochlorothiazide out of the reach of children and away from pets.

Do NOT use Hydrochlorothiazide if:

you are allergic to any ingredient in Hydrochlorothiazide

you are unable to urinate

you are taking dofetilide or ketanserin.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Hydrochlorothiazide. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have had a severe allergic reaction (eg, rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue) to a sulfonamide medicine (eg, sulfamethoxazole)

if you have gout, liver problems, (eg, cirrhosis), lupus, kidney problems, diabetes, asthma, parathyroid gland problems, or high blood cholesterol or lipid levels

if you have high or low blood electrolyte levels (eg, sodium, potassium, magnesium, calcium)

if you are taking another medicine for high blood pressure.

Some medicines may interact with Hydrochlorothiazide. Tell your health care provider if you are taking any other medicines, especially any of the following:

Digoxin, dofetilide, or ketanserin because the risk of irregular heartbeat may be increased

Barbiturates (eg, phenobarbital), corticotropin, corticosteroids (eg, prednisone), or narcotic pain medicines (eg, codeine) because they may increase the risk of Hydrochlorothiazide's side effects

Cholestyramine, colestipol, or nonsteroidal anti-inflammatory medicines (NSAIDs) (eg, ibuprofen) because they may decrease Hydrochlorothiazide's effectiveness

Diazoxide or lithium because the risk of their side effects may be increased by Hydrochlorothiazide

Diabetes medicines (eg, glipizide, metformin) or insulin because their effectiveness may be decreased by Hydrochlorothiazide.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Hydrochlorothiazide may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Hydrochlorothiazide may cause dizziness or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Hydrochlorothiazide with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Hydrochlorothiazide may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.

Your doctor may also prescribe a potassium supplement for you. If so, take the potassium supplement exactly as prescribed. Do not start taking additional potassium on your own or change your diet to include more potassium without first checking with your doctor.

Tell your doctor or dentist that you take Hydrochlorothiazide before you receive any medical or dental care, emergency care, or surgery.

Tell your doctor if you will be exposed to high temperatures. The risk of certain side effects (eg, low blood sodium levels) may be increased in hot weather.

Hydrochlorothiazide may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Hydrochlorothiazide. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.

Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.

Hydrochlorothiazide may raise your blood sugar. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away.

Diabetes patients - Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

Hydrochlorothiazide may interfere with certain lab tests, including parathyroid function tests. Be sure your doctor and lab personnel know you are taking Hydrochlorothiazide.

Lab tests, including kidney function, blood pressure, and electrolyte levels, may be performed while you use Hydrochlorothiazide. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Hydrochlorothiazide with caution in the elderly; they may be more sensitive to its effects, especially dizziness.

Pregnancy and breast-feeding: Hydrochlorothiazide may cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Hydrochlorothiazide while you are pregnant. Hydrochlorothiazide is found in breast milk. If you are or will be breast-feeding while you use Hydrochlorothiazide, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Constipation; diarrhea; dizziness; lightheadedness (especially when sitting up or standing); loss of appetite; nausea; temporary blurred vision.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; dark urine; decreased urination; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; increased thirst; joint pain, swelling, warmth, or redness (especially of the big toe joint); mental or mood changes; muscle pain or cramps; numbness or tingling; red, swollen, blistered, or peeling skin; seizures; severe or persistent dizziness; severe or persistent nausea or stomach pain; shortness of breath; unusual bruising or bleeding; unusual drowsiness, restlessness, tiredness, or weakness; unusually dry mouth; vomiting; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Hydrochlorothiazide (Linatil comp) Delivery

Residents of the USA can order Hydrochlorothiazide (Linatil comp) to any city, to any address, for example to Los Angeles, Ft Worth, Atlanta or Phoenix. You can order delivery of a Hydrochlorothiazide (Linatil comp) to the Denmark, Puerto Rico, Israel or any other country in the world.

Kuric Cream Indications, Side Effects, Warnings, Kuric

Kuric cream

Kuric cream is used for:

Treating certain fungal infections of the skin.

Kuric cream is an imidazole antifungal. It works by killing sensitive fungi by interfering with the formation of the fungal cell membrane and weakening it. The weakened cell membrane allows the cell contents to leak out and results in the death of the fungus.

Do NOT use Kuric cream if:

you are allergic to any ingredient in Kuric cream

Contact your doctor or health care provider right away if any of these apply to you.

Before using Kuric cream:

Some medical conditions may interact with Kuric cream. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have low blood sugar levels, liver disease, or porphyria (a blood disease), sulfite sensitivity, or you drink more than 3 alcohol-containing drinks a day

Some MEDICINES MAY INTERACT with Kuric cream. Because little, if any, of Kuric cream is absorbed into the blood, the risk of it interacting with another medicine is low.

Ask your health care provider if Kuric cream may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Kuric cream:

Use Kuric cream as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Clean the affected area with soap and water and dry thoroughly. Apply enough medicine to cover the affected area. Rub in gently. Do not cover unless directed otherwise by your doctor. Wash your hands immediately after using Kuric cream, unless your hands are part of the treated area.

Keep Kuric cream out of your eyes, nose, and mouth. If this occurs, wash with water and contact your doctor, nurse, or pharmacist.

To clear up your infection completely, use Kuric cream for the full course of treatment. Keep using it even if you feel better in a few days.

If you miss a dose of Kuric cream, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Kuric cream.

Important safety information:

Be sure to use Kuric cream for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.

If you use topical products too often, your condition may become worse.

If your symptoms do not improve or if they become worse, check with your doctor.

Some of these products contain sulfites. Sulfites may cause an allergic reaction in some patients (eg, asthma patients). If you have ever had an allergic reaction to sulfites, ask your pharmacist if your product has sulfites in it.

Talk to your doctor before you take Kuric cream if you drink more than 3 drinks with alcohol per day.

Kuric cream should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.

PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Kuric cream while you are pregnant. It is not known if this medicine is found in breast milk. Do not breast-feed while using Kuric cream.

Possible side effects of Kuric cream:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Itching; mild irritation or stinging.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); reddening, blistering, peeling, itching, or burning of your skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA .

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center. or emergency room immediately.

Proper storage of Kuric cream:

Store Kuric cream between 59 and 77 degrees F (15 and 25 degrees C). Store in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Kuric cream out of the reach of children and away from pets.

General information:

If you have any questions about Kuric cream, please talk with your doctor, pharmacist, or other health care provider.

Kuric cream is to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Kuric cream or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Kuric cream. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Kuric cream. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Kuric cream.

Review Date: August 8, 2016

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

More about Kuric (ketoconazole topical)

Efavirenz - Brand Name List From, Stocrit

Efavirenz

See also.

Disclaimer: The indications, uses and warnings for individual medications outside the USA are determined by local regulatory bodies in each country or region. The Drugs. com website is intended primarily for audiences in the United States and its territories. Indications, uses and warnings on Drugs. com patient information leaflets are derived from FDA product labels and may differ in countries outside the USA. Every effort has been made to ensure that the information provided on this page is accurate, up-to-date and complete, but no guarantee is made to that effect. Drugs. com does not endorse drugs, diagnose patients or recommend specific therapies. The information on this page is not a substitute for the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that a drug or drug combination is safe, effective or appropriate for any given patient. Drugs. com does not assume any responsibility for any aspect of healthcare administered with the aid of information provided here. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Always consult your doctor or healthcare specialist for medical advice.

Chemical formula: C14H9ClF3NO2 Drugbank ID: DB00625 ATC code(s): J05AG03, J05AR06, J05AR11

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Lipitor - Cholesterol Lowering, Lorvaten

Common use Atorvastatin is a cholesterol-lowering used to treat high cholesterol or to lower the risk of stroke, heart attack or other heart complications in patients with coronary heart disease or second type of diabetes. Atorvastatin helps to clear harmful low-density lipoprotein cholesterol out of the blood and by limiting the body's ability to form new LDL cholesterol. Thus it can help prevent hardening of the arteries and heart disease, conditions that can lead to vascular disease, heart attack, stroke.

Dosage and direction Take it orally once a day with or without food. Atorvastatine should be taken with full glass of water. The common dose for adults is 10 mg once daily. The common dose for children from 10 to 17 years of age is 10 mg once daily. Using Atorvastatin in children less than 10 years of age is not recommended and dose must be determined by your family doctor.

Note: this instruction presented here just for review. It's very necessary to consult with your doctor before using. It help you to get best results.

Precautions People with diabetes, underactive thyroid glands, kidney disease, or muscle disease sometimes need additional tests before or during atorvastatin therapy since dosage adjustments may be required. Do not use large amounts of alcohol while taking this drug because it can worsen the adverse effects of this medicine on the liver. Atorvastatin should not be used during pregnancy, becoming pregnant or lactating without doctor's advice. Do not use Atorvastatin before breast-feeding without doctor's permission.

Contraindications Atorvastatin is not allowed to people who have liver problems or unexplained abnormal liver function tests. Do not use it if you are taking an HIV protease inhibitor (eg, ritonavir), itraconazole, or mibefradil. Also Atorvastatin contraindicated if you are hypersensitive to any components of this medication, pregnancy or breast-feeding.

Possible side effect They may include all types of an allergic reaction. Also the most possible side effects include: muscle pain, tenderness, or weakness with fever or flu symptoms; or nausea, clay-colored stools, stomach pain, low fever, jaundice, loss of appetite, dark urine. Less serious include: mild nausea or stomach pain, stomach upset, heartburn; constipation, bloating, gas; stuffy nose; itching, skin rash; headache. If you experience one of them stop using Atorvastatin and tell your doctor as soon as possible. Also consult with your doctor about any side effect that seems unusual.

Drug interaction Atrovastatin interact with the following drugs: digoxin; erythromycin or clarithromycin; gemfibrozil or fenofibrate; niacin; an antifungal medication such as itraconazole, fluconazole, or ketoconazole; drugs that weaken your immune system such as cancer medicine or steroids, cyclosporine, sirolimus, tacrolimus, and others; HIV or AIDS medication such as indinavir, nelfinavir, ritonavir, lopinavir-ritonavir, or saquinavir. Also note that interaction between two medications does not always mean that you must stop taking one of them. As usual it affects the the effect of drugs, so consult with your doctor about how it interactions are being managed or should be managed.

If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not increase your recommended dose. Take your usually dose next day in the same regularly time.

Symptoms of Atorvastatin are not known well but most possible of them include a severe drop in blood pressure and a faster heartbeat. If you experience one of them or any unusual symptoms, call your doctor immediately.

Store at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture, kids and pets. Do not use after expiration term.

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Common use Atorvastatin is a cholesterol-lowering used to treat high cholesterol or to lower the risk of stroke, heart attack or other heart complications in patients with coronary heart disease or second type of diabetes. Atorvastatin helps to clear harmful low-density lipoprotein cholesterol out of the blood and by limiting the body's ability to form new LDL cholesterol. Thus it can help prevent hardening of the arteries and heart disease, conditions that can lead to vascular disease, heart attack, stroke.

Dosage and direction Take it orally once a day with or without food. Atorvastatine should be taken with full glass of water. The common dose for adults is 10 mg once daily. The common dose for children from 10 to 17 years of age is 10 mg once daily. Using Atorvastatin in children less than 10 years of age is not recommended and dose must be determined by your family doctor.

Note: this instruction presented here just for review. It's very necessary to consult with your doctor before using. It help you to get best results.

Precautions People with diabetes, underactive thyroid glands, kidney disease, or muscle disease sometimes need additional tests before or during atorvastatin therapy since dosage adjustments may be required. Do not use large amounts of alcohol while taking this drug because it can worsen the adverse effects of this medicine on the liver. Atorvastatin should not be used during pregnancy, becoming pregnant or lactating without doctor's advice. Do not use Atorvastatin before breast-feeding without doctor's permission.

Contraindications Atorvastatin is not allowed to people who have liver problems or unexplained abnormal liver function tests. Do not use it if you are taking an HIV protease inhibitor (eg, ritonavir), itraconazole, or mibefradil. Also Atorvastatin contraindicated if you are hypersensitive to any components of this medication, pregnancy or breast-feeding.

Possible side effect They may include all types of an allergic reaction. Also the most possible side effects include: muscle pain, tenderness, or weakness with fever or flu symptoms; or nausea, clay-colored stools, stomach pain, low fever, jaundice, loss of appetite, dark urine. Less serious include: mild nausea or stomach pain, stomach upset, heartburn; constipation, bloating, gas; stuffy nose; itching, skin rash; headache. If you experience one of them stop using Atorvastatin and tell your doctor as soon as possible. Also consult with your doctor about any side effect that seems unusual.

Drug interaction Atrovastatin interact with the following drugs: digoxin; erythromycin or clarithromycin; gemfibrozil or fenofibrate; niacin; an antifungal medication such as itraconazole, fluconazole, or ketoconazole; drugs that weaken your immune system such as cancer medicine or steroids, cyclosporine, sirolimus, tacrolimus, and others; HIV or AIDS medication such as indinavir, nelfinavir, ritonavir, lopinavir-ritonavir, or saquinavir. Also note that interaction between two medications does not always mean that you must stop taking one of them. As usual it affects the the effect of drugs, so consult with your doctor about how it interactions are being managed or should be managed.

If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not increase your recommended dose. Take your usually dose next day in the same regularly time.

Symptoms of Atorvastatin are not known well but most possible of them include a severe drop in blood pressure and a faster heartbeat. If you experience one of them or any unusual symptoms, call your doctor immediately.

Store at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture, kids and pets. Do not use after expiration term.

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Common use Atorvastatin is a cholesterol-lowering used to treat high cholesterol or to lower the risk of stroke, heart attack or other heart complications in patients with coronary heart disease or second type of diabetes. Atorvastatin helps to clear harmful low-density lipoprotein cholesterol out of the blood and by limiting the body's ability to form new LDL cholesterol. Thus it can help prevent hardening of the arteries and heart disease, conditions that can lead to vascular disease, heart attack, stroke.

Dosage and direction Take it orally once a day with or without food. Atorvastatine should be taken with full glass of water. The common dose for adults is 10 mg once daily. The common dose for children from 10 to 17 years of age is 10 mg once daily. Using Atorvastatin in children less than 10 years of age is not recommended and dose must be determined by your family doctor.

Note: this instruction presented here just for review. It's very necessary to consult with your doctor before using. It help you to get best results.

Precautions People with diabetes, underactive thyroid glands, kidney disease, or muscle disease sometimes need additional tests before or during atorvastatin therapy since dosage adjustments may be required. Do not use large amounts of alcohol while taking this drug because it can worsen the adverse effects of this medicine on the liver. Atorvastatin should not be used during pregnancy, becoming pregnant or lactating without doctor's advice. Do not use Atorvastatin before breast-feeding without doctor's permission.

Contraindications Atorvastatin is not allowed to people who have liver problems or unexplained abnormal liver function tests. Do not use it if you are taking an HIV protease inhibitor (eg, ritonavir), itraconazole, or mibefradil. Also Atorvastatin contraindicated if you are hypersensitive to any components of this medication, pregnancy or breast-feeding.

Possible side effect They may include all types of an allergic reaction. Also the most possible side effects include: muscle pain, tenderness, or weakness with fever or flu symptoms; or nausea, clay-colored stools, stomach pain, low fever, jaundice, loss of appetite, dark urine. Less serious include: mild nausea or stomach pain, stomach upset, heartburn; constipation, bloating, gas; stuffy nose; itching, skin rash; headache. If you experience one of them stop using Atorvastatin and tell your doctor as soon as possible. Also consult with your doctor about any side effect that seems unusual.

Drug interaction Atrovastatin interact with the following drugs: digoxin; erythromycin or clarithromycin; gemfibrozil or fenofibrate; niacin; an antifungal medication such as itraconazole, fluconazole, or ketoconazole; drugs that weaken your immune system such as cancer medicine or steroids, cyclosporine, sirolimus, tacrolimus, and others; HIV or AIDS medication such as indinavir, nelfinavir, ritonavir, lopinavir-ritonavir, or saquinavir. Also note that interaction between two medications does not always mean that you must stop taking one of them. As usual it affects the the effect of drugs, so consult with your doctor about how it interactions are being managed or should be managed.

If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not increase your recommended dose. Take your usually dose next day in the same regularly time.

Symptoms of Atorvastatin are not known well but most possible of them include a severe drop in blood pressure and a faster heartbeat. If you experience one of them or any unusual symptoms, call your doctor immediately.

Store at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture, kids and pets. Do not use after expiration term.

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Common use Atorvastatin is a cholesterol-lowering used to treat high cholesterol or to lower the risk of stroke, heart attack or other heart complications in patients with coronary heart disease or second type of diabetes. Atorvastatin helps to clear harmful low-density lipoprotein cholesterol out of the blood and by limiting the body's ability to form new LDL cholesterol. Thus it can help prevent hardening of the arteries and heart disease, conditions that can lead to vascular disease, heart attack, stroke.

Dosage and direction Take it orally once a day with or without food. Atorvastatine should be taken with full glass of water. The common dose for adults is 10 mg once daily. The common dose for children from 10 to 17 years of age is 10 mg once daily. Using Atorvastatin in children less than 10 years of age is not recommended and dose must be determined by your family doctor.

Note: this instruction presented here just for review. It's very necessary to consult with your doctor before using. It help you to get best results.

Precautions People with diabetes, underactive thyroid glands, kidney disease, or muscle disease sometimes need additional tests before or during atorvastatin therapy since dosage adjustments may be required. Do not use large amounts of alcohol while taking this drug because it can worsen the adverse effects of this medicine on the liver. Atorvastatin should not be used during pregnancy, becoming pregnant or lactating without doctor's advice. Do not use Atorvastatin before breast-feeding without doctor's permission.

Contraindications Atorvastatin is not allowed to people who have liver problems or unexplained abnormal liver function tests. Do not use it if you are taking an HIV protease inhibitor (eg, ritonavir), itraconazole, or mibefradil. Also Atorvastatin contraindicated if you are hypersensitive to any components of this medication, pregnancy or breast-feeding.

Possible side effect They may include all types of an allergic reaction. Also the most possible side effects include: muscle pain, tenderness, or weakness with fever or flu symptoms; or nausea, clay-colored stools, stomach pain, low fever, jaundice, loss of appetite, dark urine. Less serious include: mild nausea or stomach pain, stomach upset, heartburn; constipation, bloating, gas; stuffy nose; itching, skin rash; headache. If you experience one of them stop using Atorvastatin and tell your doctor as soon as possible. Also consult with your doctor about any side effect that seems unusual.

Drug interaction Atrovastatin interact with the following drugs: digoxin; erythromycin or clarithromycin; gemfibrozil or fenofibrate; niacin; an antifungal medication such as itraconazole, fluconazole, or ketoconazole; drugs that weaken your immune system such as cancer medicine or steroids, cyclosporine, sirolimus, tacrolimus, and others; HIV or AIDS medication such as indinavir, nelfinavir, ritonavir, lopinavir-ritonavir, or saquinavir. Also note that interaction between two medications does not always mean that you must stop taking one of them. As usual it affects the the effect of drugs, so consult with your doctor about how it interactions are being managed or should be managed.

If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not increase your recommended dose. Take your usually dose next day in the same regularly time.

Symptoms of Atorvastatin are not known well but most possible of them include a severe drop in blood pressure and a faster heartbeat. If you experience one of them or any unusual symptoms, call your doctor immediately.

Store at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture, kids and pets. Do not use after expiration term.

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Progynova 1 - Mg And 2 - Mg Tablets, Progynova

PROPRIETARY NAME (and dosage form):

PROGYNOVA 1 mg AND 2 mg TABLETS

For estrogen therapy of climacteric complaints in the postmenopause

COMPOSITION Progynova tablets contain estradiol valerate (estra-1,3,5(10)-triene-3,17beta-diol 17-valerate) 1,0 mg and 2,0 mg respectively.

PHARMACOLOGICAL CLASSIFICATION A. 21.8.1 Estrogens.

PHARMACOLOGICAL ACTION Progynova contains estradiol valerate, an ester of the endogenous female estrogen, which following regular oral administration eliminates the characteristic estrogen deficiency symptoms in the postmenopause or after oophorectomy or radiological castration for non-carcinomatous diseases.

INDICATIONS Climacteric complaints after the cessation of monthly bleeding or deficiency symptoms after oophorectomy or radiological castration for non-carcinomatous diseases, such as hot flushes, outbreaks of sweat, sleep disturbances, depressive moods, irritability, headaches, dizziness, bladder irritation, signs of muco-cutaneous involution.

CONTRA-INDICATIONS Pregnancy; severe disturbances of liver function; jaundice or persistent itching during a previous pregnancy; Dubin-Johnson syndrome; Rotor syndrome; previous or existing liver tumours; existing or previous thromboembolic processes (eg stroke, myocardial infarction); sickle-cell anaemia; existing or suspected hormone-dependent tumours of the uterus or mammae; endometriosis; severe diabetes with vascular changes; congenital disturbances of lipometabolism; otosclerosis with deterioration in previous pregnancies.

DOSAGE AND DIRECTIONS FOR USE Before starting Progynova a thorough general medical and gynaecological examination (including the breasts) should be carried out. Unless otherwise prescribed by the doctor, 1 tablet Progynova 2 mg is taken daily after a meal. The tablets are to be swallowed whole with some liquid. After each 21-day regimen there must be a pause in tablet-taking of at least 1 week. In the course of treatment, the doctor may decide to reduce the dose to 1 tablet Progynova 1 mg daily. Under this lower dose, too, a tablet-free interval of at least 1 week should be observed after each 21-day regimen. As a general rule, Progynova treatment should be discontinued every 6 months in order to verify the persistence of complaints requiring treatment.

SIDE EFFECTS AND SPECIAL PRECAUTIONS A feeling of tension in the breasts, gastric upsets, nausea and vomiting, headaches, increase in body weight, and uterine bleeding can occur. The doctor should be informed if other medical preparations are taken regularly (eg barbiturates, phenylbutazone, hydantoins, rifampicin, ampicillin) since they can impair the action of Progynova. If uterine bleeding occurs, the patient must consult her doctor in order to clarify the cause. Gynaecological check-ups should be carried out at about 6-month intervals. The doctor should be informed if the patient suffers from the following disorders: diabetes, high blood pressure, varicose veins, otosclerosis, multiple sclerosis, epilepsy, porphyria, tetany, chorea minor. In all these cases, and also where there is a history of phlebitis, strict medical supervision is necessary. Not for use during pregnancy. An increased incidence of endometrial uterine carcinoma, related to the continuous use of estrogens in the postmenopausal period has been reported. Since this suspected risk cannot be entirely ruled out, endometrial hyperplasia should be avoided in unopposed estrogen treatment, eg by the additional administration of a progestogen. It is in any case essential to adhere to the dosage scheme prescribed by the doctor, including the instructions regarding tablet-free intervals and length of treatment, and to keep the appointments made for gynaecological check-ups. In rare cases benign and in even rarer cases malignant liver tumours leading in isolated cases to life-threatening intraabdominal haemorrhage have been observed after the use of hormonal substances such as the one contained in Progynova. If severe upper abdominal complaints, liver enlargement or signs of intraabdominal haemorrhage occur, a liver tumour should be included in the differential-diagnostic considerations and, if necessary, the preparation withdrawn. Reasons for the immediate discontinuation of Progynova Occurrence for the first time of migrainous headaches or more frequent occurrence of unusually severe headaches; sudden perceptual disorders (eg disturbances of vision or hearing); first signs of thrombophlebitis or thromboembolic symptoms (for example unusual pains in or swelling of the legs; stabbing pains on breathing or coughing for no apparent reason); a feeling of pain and tightness in the chest; pending operations (six weeks beforehand) and immobilisation, for instance following accidents; onset of jaundice; onset of hepatitis; itching of the whole body; increase in epileptic seizures; significant rise in blood pressure. Estradiol and other estrogens may cause amenorrhoea, depression, dizziness, gynaecomastia (main side effect in the male), hypercalcaemia (if used in metastatic conditions such as breast cancer), nitrogen retention, oedema, skin rashes, sodium retention, and alterations in liver function. High doses of estrogens may cause premature closure of epiphysis and depression of malignant neoplasms while low doses may stimulate the growth of malignant neoplasms.

KNOWN SYMPTOMS OF OVERDOSAGE AND PARTICULARS OF ITS TREATMENT See "Side effects and special precautions". Symptomatic treatment according to conventional methods.

IDENTIFICATION Progynova 1 mg: Beige, lustrous coated tablets. Progynova 2 mg: Blue, lustrous coated tablets.

PRESENTATION Progynova 1 mg: Blister packs of 21 coated tablets. Progynova 2 mg: Blister packs of 21 coated tablets.

STORAGE INSTRUCTIONS Store below 30°C. For shelf-life, refer to imprint on the pack. Keep out of reach of children.

REGISTRATION NUMBER Progynova 1 mg: B/21.8.1/16

REFERENCE NUMBER Progynova 2 mg: G.2981 (Act 101/1965)

NAME AND BUSINESS ADDRESS OF THE APPLICANT Schering (Pty) Ltd (Reg No: 1964/009072/07) 106 Sixteenth Road Randjespark Midrand 1685 P O Box 5278 Halfway House 1685

DATE OF PUBLICATION OF THIS PACKAGE INSERT 20 September 1982

SCHERING (PTY) LTD (Reg No: 1964/009072/07) Subsidiary of Schering AG Germany

Updated on this site: April 2003 Current: January 2005 Source: Pharmaceutical Industry SAEPI HOME PAGE TRADE NAME INDEX GENERIC NAME INDEX FEEDBACK Information presented by Malahyde Information Systems © Copyright 1996-2005

Modolex® 40 Mg, Modolex

Modolex ® 40 mg/20 mg v 1 g, rektalno mazilo

Lastnosti in delovanje:

Vsebuje dve ucinkovini: vazoprotektiv kalcijev dobesilat in lokalni anestetik lidokain.

Kalcijev dobesilat zašcitno deluje na krvne zile in zmanjšuje otekline.

Lidokain deluje lokalno protibolecinsko in tako lajša pekoc obcutek ter bolecino na predelu tezav.

Namenjeno:

Uporablja se pri:

notranjih in zunanjih hemoroidih (zlata zila),

srbecici in ekcemih okoli zadnjicne odprtine,

analnih razpokah,

lajšanju tezav pred operacijo hemoroidov in po njej.

Po nasvetu zdravnika ga lahko uporabljate tudi za lajšanje akutne tromboze hemoroidov.

Dobro je vedeti:

Hitro ublazi otekline, vnetje in krvavitve iz hemoroidov (zlate zile) ter lokalno vlazi.

Zdravilo vsebuje pomozne snovi: butilhidroksianizol, cetilalkohol in propilenglikol.

Kako uporabljati:

Pri notranjih hemoroidih

Pri zunanjih hemoroidih

Odrasli in mladostniki, stari nad 14 let

Uporabite zjutraj in zvecer. Na tubo namestite nastavek in ga vstavite cim globlje v zadnjicno odprtino ter rahlo iztisnite mazilo.

Prizadeto mesto dva - do trikrat na dan na tanko namazite.

Rektalno mazilo je namenjeno samo za zunanjo uporabo. Zdravilo uporabljajte po odvajanju blata. Predel zadnjika pred uporabo dobro ocistite.

Ce imate zmanjšano delovanje ledvic ali ledvicno odpoved, smete uporabljati zdravilo le krajši cas. Pri mladostnikih, mlajših od 14 let, varnost uporabe ni bila potrjena.

Po uporabi si temeljito umijte roke. Zdravila ne uporabljajte vec kot 14 dni. Ce se po tem casu tezave ne umirijo, svetujemo pregled pri zdravniku.

Ne uporabljajte pri:

alergiji (preobcutljivosti) na kalcijev dobesilat, lidokain ali katerokoli drugo sestavino zdravila.

Vsebina pakiranja:

Tuba s 30 g mazila in plasticni nastavek.

Nacin izdaje zdravila:

Brez recepta v lekarnah.

Na slovenskem trgu je na voljo naslednje pakiranje:

30 g mazila z nastavkom

Navodilo za uporabo zdravila

Povzetek glavnih znacilnosti zdravila

Na slovenskem trgu je na voljo naslednje pakiranje:

30 g mazila z nastavkom

Navodilo za uporabo zdravila

Povzetek glavnih znacilnosti zdravila

Pred uporabo zdravil natancno preberite navodilo! O tveganju in nezelenih ucinkih se posvetujte z zdravnikom ali s farmacevtom.

Zaprtje in hemoroidi

Najpogostejsa prebavna tezava ljudi v razvitem svetu je zaprtje. Mocno napenjanje pri odvajanju trdega, suhega blata zveca tlak v trebuhu in povzroci cezmerno polnjenje ven v zadnjiku, kar vodi v nastanek hemoroidov.

Severe Late-Onset Recurrent Epithelial Erosion With Diffuse Lamellar Keratitis After Laser In Situ K

Severe late-onset recurrent epithelial erosion with diffuse lamellar keratitis after laser in situ keratomileusis ?

Naoko Asano-Kato. MD . a. ,

Ikuko Toda. MD a ,

Kazuo Tsubota. MD b

a Minamiaoyama Eye Clinic (Asano-Kato, Toda), Tokyo, Japan

b Department of Ophthalmology, Tokyo Dental College (Tsubota), Tokyo, Japan.

Accepted 10 February 2003, Available online 7 November 2003

Abstract

A 39-year-old woman had laser in situ keratomileusis that was complicated by intraoperative epithelial erosion in both eyes. Seven months after surgery, the patient returned, complaining of pain and blurred vision in the left eye. Slitlamp examination revealed corneal epithelial erosion with severe diffuse lamellar keratitis (DLK). Reepithelialization was complete in several days. However, severe inflammation remained until systemic steroids were administered. Recurrent erosions can lead to a serious inflammatory reaction such as DLK because of the presence of the flap—stroma interface.

None of the authors has a financial or proprietary interest in any material or method mentioned.

Reprint requests to Naoko Asano-Kato, MD, Department of Ophthalmology, Tokyo Dental College, 5-11-13 Sugano, Ichikawa-shi, Chiba, 272-8513, Japan.

Copyright © 2003 ASCRS and ESCRS. Published by Elsevier Inc. All rights reserved.

Lasix Vs Aldactone, Fosicomp

If you are or will be breast-feeding while you use Pyridium, check with your doctor. Cheap Nefrecil Phenazopyridine

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Pardelprin Mr Capsules 75mg, Pardelprin

PARDELPRIN MR CAPSULES 75MG

Transcript

Pardelprin MR 75mg capsules Indometacin modified release capsules Read all of this leaflet carefully before you start taking this medicine. Keep this leaflet. You may need to read it again. If you have any further questions, ask your doctor or pharmacist. If any of the side effects gets serious or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist. This medicine has been prescribed for you. Do not pass it on to others. It may harm them, even if their symptoms are the same as yours. In this leaflet: 1. What Pardelprin MR capsules are and what they are used for 2. Before you use Pardelprin MR capsules 3. How to use Pardelprin MR capsules 4. Possible side effects 5. How to store Pardelprin MR capsules 6. Further information

What Pardelprin MR capsules are and what they are used for

Pardelprin MR capsules belong to a group of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). These medicines are pain killers which reduce swelling. Pardelprin MR capsules are for: inflammatory diseases of the joints such as rheumatoid arthritis, osteoarthritis and degenerative hip disease disorders occurring around a joint such as inflammation of: - fluid surrounding a joint (bursitis) - tendons (tendinitis) - a joint membrane (synovitis) - the lining of a tendon (tenosynovitis) - the capsule surrounding a joint (capsulitis) pain and stiffness in the backbone (ankylosing spondylitis) sprains and strains (acute muscle and bone disorders) lower back pain pain and swelling following muscle or bone surgery period pain.

Before you take Pardelprin MR capsules

Do not take Pardelprin MR capsules if you: are in the last three months of pregnancy are allergic (hypersensitive) to indometacin or any of the ingredients of Pardelprin MR capsules (see section 6) are allergic (hypersensitive) to aspirin, ibuprofen or other NSAIDs or you have developed signs of asthma (wheezing), runny nose, swelling of the face, lips, tongue or throat or a skin rash with pale or red irregular raised patches with severe itching, when taking these medicines are taking other NSAIDs (e. g. Naproxen) or COX II inhibitors (e. g. Celecoxib) suffer with angioneurotic oedema (swelling of the face, lips, tongue or throat) have or have had a history of two or more episodes of peptic ulcer (ulcer in your stomach or duodenum) or bleeding in your stomach or intestines in the past. Symptoms may include vomiting particles that look like coffee-grounds, black tarry stools and blood in your faeces (stools/motions) have severe liver, kidney or heart problems have had bleeding in your stomach or intestines or perforation after taking NSAIDs have nasal obstruction (nasal polyps).

Pardelprin MR capsules must not be used in children.

Check with your doctor before taking Pardelprin MR capsules if you are: elderly (see Other warnings) to have a vaccination with a live vaccine a woman trying to become pregnant or undergoing investigation for infertility. Indometacin may make it more difficult to become pregnant. You should inform your doctor if you are planning to become pregnant or if you have problems becoming pregnant taking a medicine which is poisonous to the kidneys such as cisplatin or vancomycin.

or if you have: a history of high blood pressure or congestive heart failure a bleeding or blood clotting disorder mental health problems e. g. mood changes epilepsy Parkinson’s Disease (tremor, stiffness and shuffling) any infection or sepsis (severe infection) any liver, kidney or heart problems fluid retention which may be caused by diseases of the heart or kidneys asthma or a history of asthma have or have a history of gastrointestinal diseases such as ulcerative colitis or Crohns disease systemic lupus erythematosus (SLE) or other connective tissue disorders diabetes a decreased amount of fluid around the cells of the body (extracellular volume depletion) peripheral arterial disease (a problem with the circulation in the legs). Other warnings If you are elderly or you have previously had stomach ulcers, you have a higher risk of getting side effects, especially from the stomach. Your doctor should therefore prescribe the lowest dose that gives you sufficient relief. If you experience any unusual symptoms from the stomach, you must tell your doctor about it. Medicines such as indometacin may be associated with a small increased risk of heart attack (“myocardial infarction”) or stroke. Any risk is more likely with high doses and prolonged treatment. Do not exceed the recommended dose or duration of treatment. If you have heart problems, previous stroke or think you might be at risk of these conditions (for example if you have high blood pressure, diabetes or high cholesterol or are a smoker) you should discuss your treatment with your doctor or pharmacist. Taking a pain killer too often or for too long can make headaches worse.

Taking other medicines Please tell your doctor or pharmacist if you are taking, or have recently taken, any other medicines, including medicines obtained without a prescription, particularly: other non-steroidal anti-inflammatory drugs (NSAIDs) including aspirin, naproxen or COX II inhibitors (e. g. celecoxib) or diflunisal (for pain and inflammation) quinolone antibiotics e. g. ciprofloxacin (to treat infections) medicines which thin the blood or which prevent blood clotting, such as warfarin or antiplatelet drugs such as clopidogrel selective serotonin reuptake inhibitors (SSRIs) e. g. fluoxetine (for depression) metformin or sulphonylureas e. g. gliclazide (for diabetes) phenytoin (for epilepsy) diazepam (for anxiety, difficulty sleeping, alcohol withdrawal, seizures and muscle spasm) medicines used to treat high blood pressure such as beta blockers (e. g. atenolol), alpha blockers (e. g. prazosin), ACE inhibitors (e. g. lisinopril), angiotensin II receptor antagonists (e. g. valsartan), hydralazine (vasodilator) or nifedipine haloperidol (an antipsychotic drug)

zalcitabine, zidovudine or ritonavir (for viral infections) cardiac glycosides e. g. digoxin (for heart failure and irregular heart beat) ciclosporin, tacrolimus or muromonab-CD3 (to suppress the immune system) corticosteriods e. g. prednisolone (used in many different diseases) cyclophosphamide or methotrexate (to treat some types of cancer and rheumatoid arthritis) desmopressin (for diabetes insipidus and frequent urination during the night) diuretics (water tablets) such as triamterene, thiazides (e. g. bendroflumethiazide) or furosemide lithium (for some mental health problems) mifepristone (for termination of pregnancy). Pardelprin MR capsules should not be taken within 8-12 days of taking mifepristone baclofen (a muscle relaxant) pentoxifylline (for blood vessel disease and leg ulcers) probenecid (for gout) tiludronic acid (for Paget’s disease of bone).

Pregnancy and breast-feeding If you are in the last three months of pregnancy you must not take Pardelprin MR capsules. You should only take Pardelprin MR capsules in the first six months of pregnancy or if you are breastfeeding under medical supervision. Always ask your doctor before taking any medicine.

Driving and using machines Pardelprin MR capsules may make you feel drowsy, dizzy or affect your vision. Make sure you are not affected before you drive or operate machinery.

Sugar intolerance If a doctor has told you that you have an intolerance to some sugars, contact your doctor before taking this medicine, as it contains sucrose and lactose.

Tests Your doctor may want to carry out tests to monitor your kidney and liver function, the levels of blood cells and the effects on your stomach and intestines (especially if you are elderly). If you have or have had a history of high blood pressure or heart failure your doctor may also want to monitor you. If you have rheumatoid arthritis you may be advised to have regular eye tests to check your sight.

Surgery If you are about to have, or have recently had surgery, please contact your doctor before using this medicine.

How to take Pardelprin MR capsules

Always take Pardelprin MR capsules exactly as your doctor has told you. If you are not sure, check with your doctor or pharmacist. Swallow the capsules with or after food or milk to reduce side effects on the stomach and intestines. Dose Adults: One capsule once or twice a day, depending on your response. For period pain, take one capsule a day starting when cramps or bleeding begin and continue for as long as symptoms last. Elderly: If you are elderly, your doctor will give you the lowest effective dose for the shortest amount of time. Children: Pardelprin MR capsules must not be used in children.

If you take more Pardelprin MR capsules than you should It is important not to take too many capsules. Contact your doctor or nearest hospital casualty department immediately, if you have taken more capsules than you should or a child accidentally swallows any. Symptoms of overdose are pain in the upper part of the stomach, bleeding in the stomach or intestines, diarrhoea, disorientation, excitation, coma, dizziness, ringing or buzzing in the ears, fainting, fits, liver damage, feeling or being sick, stomach pain, loss of appetite, drowsiness, headache, restlessness, agitation and kidney failure.

If you forget to take Pardelprin MR capsules If you forget to take your capsules, take the missed dose as soon as you remember, unless it is nearly time for your next dose. Do not take a double dose to make up for one you have missed.

Possible side effects

Like all medicines, Pardelprin MR capsules can cause side effects, although not everybody gets them. STOP TAKING the medicine and seek immediate medical help if you develop any of the following at any time during your treatment: signs of bleeding in the stomach: - Pass blood in your faeces (stools/motions) - Pass black tarry stools - Vomit any blood or dark particles that look like coffee grounds signs of an allergic reaction: - difficulty breathing or swallowing, asthma, sudden decrease in blood pressure - swelling of the face, lips, tongue or throat. STOP TAKING the medicine and tell your doctor if you experience: indigestion or heartburn abdominal pain (pains in your stomach) or other abnormal stomach symptoms effects on the stomach such as feeling or being sick, inflammation of the stomach lining, small intestine or mouth, constipation, diarrhoea, wind, perforation of previous intestinal damage, narrowing of or blockage in the intestine. abnormal liver function (as seen in blood tests) liver disease: yellowing of the skin or whites of the eyes (jaundice), inflammation of the liver (hepatitis) causing fatigue, weakness, loss of appetite, weight loss, abdominal pain, fever skin reactions such as itching, pale or red irregular raised patches with severe itching (hives), disorder characterised by blood spots, bruising and discolouring of the skin (purpura), blisters or skin that is red, flaky or peeling such as severe rash involving reddening, peeling and swelling of the skin that resembles severe burns (toxic epidermal necrolysis), circular, irregular red patches on the skin of the hands and arms (erythema multiforme), severe form of skin rash with flushing, fever, blisters or ulcers (Stevens Johnson syndrome) aseptic meningitis (stiff neck, headache, feeling or being sick, fever, disorientation) especially in those who already have an auto-immune disease such as systemic lupus erythematosus or mixed connective tissue disease. Medicines such as Indometacin may be associated with a small increased risk of heart attack (“myocardial infarction”) or stroke. Tell your doctor if you notice any of the following side effects: Blood: - small purple red spots, nosebleeds, bruising, disorder characterised by blood spots, blood clotting throughout the body, disturbance of blood count, reduction in blood cell production by the bone marrow. If you notice increased bruising, nosebleeds, sore throats, infections, excessive tiredness, breathlessness on exertion, or abnormal paleness of the skin, you should tell your doctor who may want you to have a blood test. Metabolism: - high blood sugar

sugar in the urine high blood levels of potassium (muscle cramps or pain, irregular heart beat, unusual tiredness or weakness).

Eyes: - blurred and double vision - inflammation of the optic nerve (which may cause eye pain and loss of vision) - eye pain - changes in your sight. Ear: - ringing or buzzing in the ears - hearing disturbances including deafness. Nervous system: - headache, dizziness, lightheadedness, spinning sensation (vertigo), tiredness, fainting, coma, fluid in the brain causing swelling, a feeling of general discomfort and illness, drowsiness - depression, nervousness, confusion, hallucinations, anxiety and other mental health problems, a feeling of unreality to the self (that the mind is separated from the body), difficulty sleeping - speech disorder, fits or seizures, worsening of epilepsy, disorder of the nerves causing tingling and numbness, pins and needles, uncontrolled movements, worsening of parkinsonism (tremor, stiffness and shuffling). Heart: - fluid retention causing ankle swelling, chest pain, heart failure - high or low blood pressure - racing heart beat, irregular heart beat, palpitations Blood vessels: - flushing. Breathing: - increase in the number of white blood cells in the lungs - narrowing of the airways in those who have a history of asthma or allergic disease. Stomach and intestines: - loss of appetite - development or worsening of ulcerative colitis or Crohns disease - inflammation of the pancreas causing pain and tenderness in the abdomen and back (pancreatitis). Liver: - blocked bile flow. Skin: - inflammation of blood vessels - sensitivity to sunlight or artificial light (e. g. sun beds) - tender red lumps usually on the legs (erythema nodosum) - hair loss, sweating - worsening of psoriasis (itchy scaly pink patches on the elbows, knees, scalp and other parts of the body). Muscle and bone: - muscle weakness, increased breakdown of cartilage. Kidneys: - blood in the urine

nephrotic syndrome (increased protein in urine and fluid retention) too much protein in the urine inflammation of the kidneys, reduced kidney function or kidney failure.

Reproductive system: - bleeding from the vagina - breast enlargement or tenderness, enlarged breasts in men. If you notice any of these side effects, or they get worse or you notice any side effects not listed, please tell your doctor or pharmacist.

How to store Pardelprin MR capsules

Keep out of the reach and sight of children. Store in a dry place below 25°C. Protect from light. Do not take Pardelprin MR capsules after the expiry date which is stated on the label/carton/bottle. Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

What Pardelprin MR capsules contain The active substance (the ingredient that makes the medicine work) is indometacin. Each capsule contains 75mg indometacin. The other ingredients are sucrose, corn starch, lactose, povidone, talc, magnesium stearate, polymers of methacrylic acid, acrylic acid esters, methacrylic acid esters, titanium dioxide (E171), erythrosine (E127), indigotine (E132), yellow iron oxide (E172), gelatin, shellac glaze, iron oxide black (E172).

What Pardelprin MR capsules look like and contents of the pack Pardelprin MR capsules are dark blue (head) and clear (body), hard, gelatin capsules. Pack size is 100. Marketing Authorisation Holder Actavis, Barnstaple, EX32 8NS, UK. Manufacturer Valpharma International SpA, Via G. Morgagni, 2 Pennabilli (PU), Italy. This leaflet was last revised in June 2013.

If you would like a leaflet with larger text, please contact 01271 311257.

Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

Ome 40 Ome 40 Pill - Omeprazole 40 Mg, Omlek

OME 40 OME 40 (Omeprazole Delayed Release 40 mg)

Pill imprint OME 40 OME 40 has been identified as Omeprazole delayed release 40 mg .

Omeprazole is used in the treatment of gerd; barrett's esophagus; gastritis/duodenitis; erosive esophagitis; duodenal ulcer (and more ), and belongs to the drug class proton pump inhibitors. Risk cannot be ruled out during pregnancy. Omeprazole 40 mg is not a controlled substance under the Controlled Substance Act (CSA).

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Omeprazole delayed release Imprint: OME 40 OME 40 Strength: 40 mg Color: Brown & White Shape: Capsule-shape Availability: Rx and/or OTC

Novo-Minocycline, Novo-Minocycline

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Teva-Minocycline

Novo-Minocycline 50 mg capsule

How does this medication work? What will it do for me?

Minocycline belongs to the class of medications called tetracycline antibiotics . It is used to treat infections caused by certain types of bacteria. It is most commonly used to treat certain types of skin infections, urinary tract infections, gallbladder infections, and respiratory tract infections such as bronchitis, pneumonia, and sinusitis.

This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

How should I use this medication?

The usual recommended adult dose of minocycline is 100 mg or 200 mg for the first dose, followed by 100 mg every 12 hours. The adolescent dose (for those 13 years and over) of minocycline is based on body weight. Minocycline is not recommended for children under 13 years of age.

Do not take this medication at the same time as iron preparations or antacids that contain aluminum, calcium, or magnesium, since they may reduce the absorption of minocycline.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take this medication exactly as prescribed by your doctor. Finish all of this medication, even if you start to feel better. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e. g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

What form(s) does this medication come in?

50 mg Each orange, hard gelatin capsule marked "NOVO 50" contains minocycline HCl equivalent to minocycline base 50 mg. Nonmedicinal ingredients: colloidal silicon dioxide, corn starch, FD&C Yellow No. 6, gelatin, magnesium stearate, pregelatinized starch, talc, and titanium dioxide.

100 mg Each opaque, orange and purple, hard gelatin capsule marked "NOVO 100" contains minocycline HCl equivalent to minocycline base 100 mg. Nonmedicinal ingredients: colloidal silicon dioxide, corn starch, FD&C Blue No. 1, FD&C Red No. 3, FD&C Yellow No. 6, gelatin, magnesium stearate, pregelatinized starch, talc, and titanium dioxide.

Who should NOT take this medication?

Do not take this medication if you are allergic to minocycline, other antibiotics in the tetracycline family (e. g. doxycycline), or any ingredients of the medication.

What side effects are possible with this medication?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

cramps or burning of the stomach

diarrhea

itching of the rectal or genital areas

sore mouth or tongue

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

abdominal pain

bulging soft spot on head of infants

diarrhea (severe)

headache

increased sensitivity of the skin to sunlight

joint pain, stiffness, or swelling

loss of appetite

nausea and vomiting

visual changes

yellowing of the skin

Stop taking the medication and seek immediate medical attention if any of the following occur:

symptoms of a serious skin reaction (such as a severe blistering skin rash that causes the skin to peel or fall off; fever; or bloodshot eyes)

symptoms of a severe allergic reaction (such as hives, difficulty breathing, and swelling of the face or throat)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Are any nutrients depleted by this medication?

Some medications can affect vitamin and nutrient levels in the body. Below is a list of nutrient depletions associated with this medication. Talk to your doctor or pharmacist about whether taking a supplement is recommended or if you have any questions or concerns.

Novo-Minocycline may deplete vitamin K

How can this nutrient deficiency impact me? Vitamin K plays a vital role in blood clotting and bone formation. Deficiency can result in bleeding and bone disorders such as osteoporosis, rickets, and osteomalacia. Vitamin K is available in supplements such as Webber Naturals Vitamin K+D. Before starting any nutrient supplement, always talk with your Rexall™ Pharmacist.

Novo-Minocycline may deplete potassium

How can this nutrient deficiency impact me? Potassium plays an important role in muscle contraction, helping maintain proper functioning of your heart and digestive system. Potassium is an electrolyte and helps maintain water balance, nerve conduction, and blood pressure. Deficiency increases the risk of low blood pressure and arrhythmias (irregular heartbeat). Potassium is available in supplements such as Rexall™ Potassium Citrate. Before starting any nutrient supplement, always talk with your Rexall™ Pharmacist.

Are there any other precautions or warnings for this medication?

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Birth control pills: When you use birth control pills at the same time as minocycline, they may be less effective, and you may experience an increased risk of breakthrough bleeding. Your doctor may advise that you use a second form of birth control while taking this medication.

Diarrhea: Minocycline may infrequently cause a condition called pseudomembranous colitis (serious diarrhea caused by antibiotics). If you develop severe diarrhea after starting this medication, even several weeks after treatment, contact your doctor as soon as possible.

Discoloration of teeth: The use of minocycline during tooth development (from the last trimester of pregnancy to the age of 13 years) may cause permanent discoloration of the teeth (yellow-grey-brown). Though more commonly associated with long-term use of tetracyclines, this effect has also been known to occur after taking the medication for a short time. For this reason, minocycline should not be used by children 13 years old or younger unless other medications are unlikely to be effective or can't be used.

Drowsiness/reduced alertness: People who take minocycline may experience headaches, lightheadedness, dizziness, or loss of balance. Decreased hearing has been reported rarely by those who take this medication. These symptoms may disappear during therapy and usually disappear rapidly when the medication is stopped. Avoid activities requiring alertness, such as driving vehicles or using hazardous machinery if the medication affects you in this way.

Medical conditions: If you have liver disease or lupus, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Overgrowth of organisms: The use of antibiotics may occasionally result in an overgrowth of organisms not killed by medication. This can cause conditions such as yeast infections to occur for some women. Women may be able to prevent yeast infections by eating yogurt daily while taking minocycline.

Sun sensitivity: An exaggerated sunburn reaction may occur for some people taking minocycline. If skin redness appears, stop taking the medication and check with your doctor.

Pregnancy: This medication should not be used during pregnancy. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: This medication passes into breast milk. If you are a breast-feeding mother and are taking minocycline, it may affect your baby. Do not breast-feed while taking this medication.

Children: Minocycline is not recommended for use by children younger than 13 years of age.

What other drugs could interact with this medication?

There may be an interaction between minocycline and any of the following:

alcohol

antacids containing aluminum, calcium, or magnesium

birth control pills

bismuth subsalicylate

calcium supplements

cholestyramine

colestipol

digoxin

iron and iron-containing vitamins

penicillins (e. g. penicillin V, amoxicillin, ampicillin)

potassium citrate

quinapril

retinoic acid derivatives (e. g. acitretin, tretinoin)

sodium bicarbonate or citrate

sucralfate

warfarin

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

stop taking one of the medications,

change one of the medications to another,

change how you are taking one or both of the medications, or

leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

All material © 1996-2016 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.

Pediazole Indications, Side Effects, Warnings, Diazole

Pediazole

Treating ear infections caused by certain bacteria. It may also be used for other conditions as determined by your doctor.

Pediazole is a macrolide and sulfonamide antibiotic combination. It works by slowing the growth of and killing sensitive bacteria.

Do NOT use Pediazole if:

you are allergic to any ingredient in Pediazole or to any other sulfonamide medicine (eg, sulfamethoxazole)

you are pregnant and at term (38 to 42 weeks)

you are breast-feeding a child younger than 2 months old

the patient is a child younger than 2 months old

you have severe kidney problems, bladder blockage, or anemia caused by folic acid deficiency

you have a very slow heartbeat or a certain type of irregular heartbeat (QT prolongation, long QT syndrome)

you have low blood potassium or magnesium levels

you are taking certain antiarrhythmics (eg, amiodarone, dofetilide, dronedarone, procainamide, propafenone, quinidine, sotalol), asenapine, astemizole, cisapride, diltiazem, eletriptan, an ergot alkaloid (eg, dihydroergotamine, ergotamine), an HIV protease inhibitor (eg, ritonavir), certain imidazole antifungals (eg, itraconazole, ketoconazole, voriconazole), nilotinib, pimozide, a streptogramin (eg, quinupristin/dalfopristin), terfenadine, tetrabenazine, tolvaptan, or verapamil

Contact your doctor or health care provider right away if any of these apply to you.

Before using Pediazole:

Some medical conditions may interact with Pediazole. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have diarrhea or throat inflammation

if you have a history of asthma, blood problems, a glucose-6-phosphate dehydrogenase (G6PD) deficiency, kidney or liver problems, heart problems (eg, fast, slow, or irregular heartbeat), low blood potassium or magnesium levels, myasthenia gravis, or the blood disease porphyria

if you take any medicine that may increase the risk of a certain type of irregular heartbeat (prolonged QT interval). Check with your doctor or pharmacist if you are unsure if any of your medicines may increase the risk of this type of irregular heartbeat

Some MEDICINES MAY INTERACT with Pediazole. Tell your health care provider if you are taking any other medicines, especially any of the following:

Many prescription and nonprescription medicines (eg, used for aches and pains, allergies, blood thinning, breathing problems, cancer, diabetes, erection problems, gout, hepatitis C infection, high blood calcium levels, high blood pressure, high cholesterol, HIV infection, inflammation, infections, irregular heartbeat or other heart problems, low blood sodium levels, migraine, mood or mental problems, nausea and vomiting, overactive bladder, Parkinson disease, prevention of organ transplant rejection, seizures, stomach problems, trouble sleeping), multivitamin products, and herbal or dietary supplements (eg, herbal teas, coenzyme Q10, garlic, ginseng, ginkgo, St. John's wort) may also interact with Pediazole. Ask your doctor or pharmacist if you are unsure if any of your medicines might interfere with Pediazole

This may not be a complete list of all interactions that may occur. Ask your health care provider if Pediazole may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Pediazole:

Use Pediazole as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take Pediazole by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.

Drinking extra fluids while you are taking Pediazole is recommended. Check with your doctor for instructions.

Do not eat grapefruit or drink grapefruit juice while you use Pediazole.

Pediazole works best if it is taken at the same time(s) each day.

To clear up your infection completely, take Pediazole for the full course of treatment. Keep taking it even if you feel better in a few days.

If you miss a dose of Pediazole, take it as soon as possible. If it is almost time for the next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Pediazole.

Important safety information:

Pediazole may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Pediazole with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

Mild diarrhea is common with antibiotic use. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.

Pediazole only works against bacteria; it does not treat viral infections (eg, the common cold).

Be sure to use Pediazole for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.

Long-term or repeated use of Pediazole may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.

Infrequently, a serious stomach problem called infantile hypertrophic pyloric stenosis (IHPS) has been reported in infants taking erythromycin. Contact your child's doctor right away if severe vomiting or irritability with feeding occurs.

Tell your doctor or dentist that you take Pediazole before you receive any medical or dental care, emergency care, or surgery.

Rarely, patients taking Pediazole have developed reversible hearing loss. This risk is greater if you have kidney problems or you take high doses of Pediazole. Contact your doctor if you develop decreased hearing or hearing loss.

Pediazole may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Pediazole. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.

Pediazole may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Pediazole.

Lab tests, including liver function, kidney function, complete blood counts, and urinalysis, may be performed while you use Pediazole. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Pediazole should not be used in CHILDREN younger than 2 months old; safety and effectiveness in these children have not been confirmed.

Use Pediazole with caution in the ELDERLY; they may be more sensitive to its effects, especially irregular heartbeat (prolonged QT interval).

PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Pediazole while you are pregnant. Do not take Pediazole if you are pregnant and at term (38 to 42 weeks). Pediazole is found in breast milk. Do not breast-feed while taking Pediazole.

Possible side effects of Pediazole:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; headache; loss of appetite; mild diarrhea; nausea; stomach pain; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); bloody or dark urine; bloody stools; change in the amount of urine produced; decreased hearing or hearing loss; fainting; fast or irregular heartbeat; fever, chills, or sore throat; mood or mental changes; numbness or tingling of the hands or feet; pale skin; red, swollen, blistered, or peeling skin; ringing in the ear; seizures; severe or persistent diarrhea, dizziness, or headache; severe stomach pain; shortness of breath; sore mouth or tongue; stomach cramps; symptoms of liver problems (eg, yellowing of skin or eyes; pale stools; severe or persistent nausea, vomiting, or loss of appetite; dark urine); unusual bruising or bleeding; unusual weakness or fatigue; vision changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA .

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center. or emergency room immediately. Symptoms may include blood in the urine; high fever; loss of consciousness; severe nausea, dizziness, drowsiness, headache, or vomiting; severe or persistent loss of appetite.

Proper storage of Pediazole:

Store Pediazole in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze. Throw away any unused medicine after 14 days. Store away from heat, moisture, and light. Do not store in the bathroom. Keep tightly closed. Keep Pediazole out of the reach of children and away from pets.

General information:

If you have any questions about Pediazole, please talk with your doctor, pharmacist, or other health care provider.

Pediazole is to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Pediazole or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Pediazole. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Pediazole. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Pediazole.

Review Date: August 8, 2016

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

More about Pediazole (erythromycin / sulfisoxazole)

Peromax Afo Latest In Afo Technology, Piromax

PEROMAX AFO Latest in AFO Technology

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Euro International brings you the latest in AFO technology with the carbon-fiber PEROMAX . The prepreg construction provides excellent stability and dynamic gait with a minimal weight. As a result, the PEROMAX is suitable for faster walking and higher load capacity, up to 125 kg. The Y-Shaped calf-bar allows patients with a larger calf to wear the PEROMAX comfortably. The PEROMAX can be used for peroneal paralysis, ankle-joint arthritis, and postoperative treatment of a ruptured Achilles tendon. This fine new product became available in mid-June 2006.

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Clindamycin - Brand Name List From, Euroclin

Clindamycin

See also.

Disclaimer: The indications, uses and warnings for individual medications outside the USA are determined by local regulatory bodies in each country or region. The Drugs. com website is intended primarily for audiences in the United States and its territories. Indications, uses and warnings on Drugs. com patient information leaflets are derived from FDA product labels and may differ in countries outside the USA. Every effort has been made to ensure that the information provided on this page is accurate, up-to-date and complete, but no guarantee is made to that effect. Drugs. com does not endorse drugs, diagnose patients or recommend specific therapies. The information on this page is not a substitute for the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that a drug or drug combination is safe, effective or appropriate for any given patient. Drugs. com does not assume any responsibility for any aspect of healthcare administered with the aid of information provided here. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Always consult your doctor or healthcare specialist for medical advice.

Buy Giardyl - Metronidazole - Online Without Prescriptions, Giardyl

Flagyl ER (Giardyl)

Flagyl ER is used for treating certain bacterial infections of the vagina (bacterial vaginosis). Flagyl ER is an oral antiprotozoal and antibacterial. It is thought to work by entering the bacterial cell, acting on some components of the cell, and destroying the bacteria.

Use Flagyl ER as directed by your doctor.

Take Flagyl ER by mouth on an empty stomach at least 1 hour before or 2 hours after eating.

Swallow Flagyl ER whole. Do not break, crush, or chew before swallowing.

To clear up your infection completely, take Flagyl ER for the full course of treatment. Keep taking it even if you feel better in a few days.

If you miss a dose of Flagyl ER, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Flagyl ER.

Store Flagyl ER at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Flagyl ER out of the reach of children and away from pets.

Active Ingredient: Metronidazole.

Do NOT use Flagyl ER if:

you are allergic to any ingredient in Flagyl ER or to another nitroimidazole (eg, tinidazole)

you are in the first trimestr of pregnancy

you are taking busulfan, an ergot alkaloid (eg, ergotamine), or you have taken disulfiram within the past 2 weeks

you are taking an HIV protease inhibitor that contains alcohol (eg, amprenavir solution); check with your pharmacist if you are unsure if the medicine contains alcohol

you drink alcohol.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Flagyl ER. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have nerve, brain, or blood problems; Crohn disease; or a history of liver problems or seizures.

Some medicines may interact with Flagyl ER. Tell your health care provider if you are taking any other medicines, especially any of the following:

Disulfiram because side effects, such as mental or mood changes, may occur

Amiodarone because the risk of irregular heartbeat may be increased

Barbiturates (eg, phenobarbital) or phenytoin because they may decrease Flagyl ER's effectiveness

Anticoagulants (eg, warfarin), busulfan, cyclosporine, ergot alkaloids (eg, ergotamine), HIV protease inhibitors containing alcohol (eg, amprenavir solution ), lithium, or macrolide immunosuppressants (eg, tacrolimus) because the risk of their side effects may be increased by Flagyl ER.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Flagyl ER may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Flagyl ER may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Flagyl ER with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

Do not drink alcohol while you are taking Flagyl ER and for at least 3 days after the last dose.

Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.

Flagyl ER only works against bacteria; it does not treat viral infections (eg, the common cold).

Be sure to use Flagyl ER for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.

Long-term or repeated use of Flagyl ER may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.

Flagyl ER may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Flagyl ER.

Lab tests, including liver function and white blood cell counts, may be performed while you use Flagyl ER. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Flagyl ER with caution in the elderly; they may be more sensitive to its effects.

Flagyl ER should be used with extreme caution in children; safety and effectiveness in children have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Flagyl ER while you are pregnant. Do not use Flagyl ER in the first 3 months of pregnancy. Flagyl ER is found in breast milk. Do not breastfeed while taking Flagyl ER.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Appetite loss; constipation; diarrhea; dizziness; headache; metallic taste; nausea; stomach upset; vomiting.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools; decreased coordination; increased or decreased urination; numbness, tingling, or burning of the arms, hands, legs, or feet; red, swollen, blistered, or peeling skin; seizures; severe diarrhea; severe or persistent dizziness or headache; sore throat, chills, or fever; speech problems; stiff neck; stomach pain or cramps; vaginal itching, odor, or discharge; vision loss or other vision changes; white patches in the mouth.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Indonal Prirodni Pripravek, Indolan

INDONAL prirodni pripravek

Indonal Woman

Kazda zena prochazi pravidelnymi mesicnimi cykly, behem kterych se vyrazne meni hormonalni hladiny. Vytvareji se nove estrogeny a stare – vyuzite – by se mely z organismu rychle vyloucit. Zena vnima tyto zmeny jako tlaky a bolestivost v prsech a deloze. Vyuzite estrogeny maji zmenenou strukturu a mohou byt „potravou“ pro bulky, cysty a myomy v uvedenych organech.

Indonal Woman dokaze vazat nepotrebne estrogeny a vyplavit je z tela ven. Zena nasledne citi ulevu od premenstruacnich tlaku a bolesti. Indonal je taky silny antioxidant. Ma v sobe latky zvysujici imunitu organismu. Doporucujeme ho zenam pro udrzeni krasy a zdravi prsu a delohy.

Charakteristika

pomaha udrzovat zdravou hladinu zenskych hormonu

chrani tkane v prsou a deloze

zvysuje imunitu a ocistuje, je to silny antioxidant

potlacuje sireni HPV viru, ktery muze zpusobovat bunecne zmeny

je to doplnek stravy – 100% prirodni produkt (zdrojem aktivni latky je brokolice a kapustovita zelenina

Pouziti a davkovani

Doporucujeme uzivat jednu kapsli denne pro podporu imunity, zdrave hladiny zenskych pohlavnich hormonu a zdravi prsou a delohy. Pri pritomnosti lekarskeho nalezu 2 kapsle denne po dobu 3 mesicu, aby hladina ucinnych latek Indonalu neklesala. Kombinace s dalsimi leky a antibiotiky je mozna, lze ho uzivat i v prubehu radioterapie.

Idonal MAN

Charakteristika

Muzi se o uzivani preventivnich pripravku zajimaji v mensi mire nez zeny, jejich pozornost vice zaujme muzska sexualita – schopnost reprodukce. Jedno s druhym se vsak nevylucuje.

Mnoho muzu slyselo o problemech prostaty, ale ne vsichni vedi, k cemu tento organ slouzi – tvori se v nem tekutina, ktera prepravuje spermie.

Pro zdravy sexualni zivot a take „chut“ je tedy dulezite, aby byla zdrava take prostata a varlata.

Indonal Man, pomaha udrzovat tyto organy zdrave, pusobi proti nadorum, udrzuje optimalni hladiny hormonu a podporuje imunitu. Je to silny antioxidant.

Doporucujeme vsem, nejen sexualne aktivnim muzum 1 kapsli denne (trimesicni kura) na podporu zdravi pohlavnich organu.

Pripravek je take vhodny proti lidskemu papillomaviru (HPV).

Davkovani:

U muzu do 70 kg 2 cps. denne, nad 71 kg 3 cps denne. Prevetivni uzivani: jedna kapsle denne po dobu 3 mesicu, nasledne dodrzet 3 mesicni pauzu. Kombinace doplnku INDONAL MAN s jinymi leky je mozna.

Rozumnym resenim pro kazdeho muze je INDONAL MAN jako podpora pri prevenci a zdraveho sexualniho zivota.

Indonal PARTNER

Upozornujeme, ze pripravek Indonal Partner for Woman je nove dostupny pod nazvem Indonal Partner .

Nas novy produkt Indonal Partner for Woman obsahuje stejne mnozstvi ucinne latky I3C jako Indonal Woman, ale je navic obohaceny silnym antioxidantem „RESVERATROLem“ cimz je mnohem silnejsi a ucinnejsi. Zvysuje imunitu organismu a pomaha proti viru HPV, pusobi take proti mykozam a plisnim uvnitr organismu. Prave mykozy a plisne jsou v soucasne dobe velmi rozsirene a organismus se jich obtizne zbavuje. Doporucujeme ho uzivat pravidelne predevsim v mesicich, kdy citime oslabeni organismu (1 kapsli)

Resveratrol – nejsilnejsi antioxidant

Je 20? silnejsi nez vitamin C, 5? nez betakaroten a 50? ucinnejsi nez vitamin E.

Resveratrol je efektivni kosmeticky prostredek, protoze zabranuje predcasnemu starnuti, obnovuje kolagenove vlakna, pokozku udrzuje hladkou a pruznou. Funguje jako aktivator sirtuinu – enzymu chranicich bunecnou DNA, znamych jako geny mladi.

Resveratrol chrani kardiovaskularni system, ma protizanetlive, antibakterialni a protiplisnove ucinky. Snizuje hladinu cukru v krvi.

Charakteristika

pomaha udrzovat zdravou hladinu zenskych pohlavnich hormonu

chrani tkane v prsou a deloze

zvysuje imunitu a ocistuje, je to silny antioxidant

potlacuje sireni viru HPV, ktery muze zpusobovat bunecne zmeny

je to doplnek stravy – 100% prirodni produkt (zdrojem aktivni latky je brokolice a kapustovita zelenina

Pouziti a davkovani

Doporucujeme uzivat jednu kapsli denne pro podporu imunity, zdrave hladiny zenskych pohlavnich hormonu a zdravi prsou a delohy. Pri pritomnosti lekarskeho nalezu 2 kapsle denne po dobu 3 mesicu, aby hladina ucinnych latek Indonalu neklesala. Kombinace s dalsimi leky a antibiotiky je mozna, lze ho uzivat i v prubehu radioterapie.

Operace nemusi byt vzdy nutna

Duverujte Indonalu, pomohl uz tisicovkam zen

Davkovani

Dospeli: 1?1 az 1?2 tobolky denne, 10 minut pred jidlem. Zapit sklenici vody nebo caje.

Deti: starsi 3 let s hmotnosti 25 az 44 kg 1?1 tobolku denne, nad 45 kg 1?2 tobolky denne, 10 minut pred jidlem. Zapit vodou, mineralkou nebo cajem.

INDONAL je vhodne uzivat alespon 3 mesice = vyuzivat 1 baleni – 3 baleni (zavaznejsi stavy).

Upozorneni

Doplnek stravy. Tento pripravek se nesmi pouzivat jako nahrazka za leky predepsane lekarem. Pripravek neni lekem, ani nemuze nahradit pestrou a vyvazenou stravu. Pripravek ma charakteristicky zapach, ktery neznamena zhorsenou kvalitu vyrobku.

Pripravek neobsahuje zadne konzervacni latky, neobsahuje lepek, neobsahuje cukr, barviva ani latky na zvyrazneni chuti. Pripravek neni urcen detem do 3 let.

Pripravek se nesmi uzivat v dobe tehotenstvi a kojeni.

Pripravek je nevhodny pro osoby uzivajici leky na snizeni obsahu zaludecni kyseliny.

Vase dotazy na pouziti indol-3-karbinolu (INDONAL), objednavky na preventivni vysetreni delozniho cipku citlivou metodou PCR na papillomaviry, pripadne na dalsi infekce vam radi zodpovime na e-mailu: medigen@ volny. cz. telefon +420 777 269 499 Po predchozim telefonickem objednani nas muzete osobne navstivit na adrese: MediGEN s. r.o. Poliklinika Sporilov, Bozkovska 2967, Praha 4.

Slozeni v jedne kapsli

Indonal Woman

150 mg ciste ucinne latky indol-3-karbinol.

Indonal Partner

150 mg ciste ucinne latky indol-3-karbinol, 100 mg resveratrolu.

Indonal Man

150 mg ciste ucinne latky indol-3-karbinol + Saw Palmetto 45 % 100 mg.

Zelatina tobolky neobsahuje latky z hoveziho skotu.

Doplnek stravy

Neni urcen jako nahrada pestre stravy. Neprekracujte doporucene davkovani. Ukladejte mimo dosah deti. Minimalni trvanlivost vyznacena na obalu.

Vase nazory, zkusenosti:

Prosim, chtela jsem se zeptat, jestli se muze uzivat dohromady lek Esmya (uzivani na myomy) a Indonal woman. Jestli to bude mit nejaky pozitivni vliv na delohu a myomy. Dekuji.

Esmya se s Indonalem woman jiste snese. Pozitivni vliv na stagnaci ci lepe zmenseni myomu by velmi pravdepodobne byt mel hlavne diky ucinku ulipristal acetatu v Esmyi. O pridatnem efektu I3C lze pouze spekulovat. Nicmene mi prijde velmi vhodne navazat na 3 mesicni cyklus Esmyi Indonal for woman na 3 mesice a dle efektu tento „pulz“ jeste jednou zopakovat…pripadne po ukonceni lecby ulipristalem pokracovat dlouhodobe s I3C v cyklech a 3 mesice s 3 mesicni pauzou.

6. 1. 2016 13:37 Hana Vrzalova

Dobry den, je vhodne pouzivat Indonal, jestli zaroven uzivam rano na lacno pred jidlem Helicid? Pri kontrolnich sterech mi byly zjisteny mirne zmeny deloznim cipku, tak jsem slysela ze uzivani tohoto potravinoveho dopnku by mohlo byt uzitecne. Je to tak?

Ano, pripravek by mohl pomoci.

10. 1. 2016 19:36 Marketa

Dobry den, mohu se zeptat:

Je nejaka sance, ze HPV zmizi pri uzivani Indonalu Partner?

Je mozne, aby se zdrav. stav pacientky zhorsil?

Jak je to s partnerem, je potreba, aby tento pripravek taky bral? Jde mi o prenos HPV.

Dekuji za odpoved.

sance, ze HPV infekce zmizi („vycisti se“) skutecne je, at uz s Indonalem nebo i bez nej.

urcite je i mozne, aby se zdravotni stav pacientky zhorsil (chapu to tak, ze HPV infekce a nasledna ji vyvolana dysplasie epitelu hrdla delozniho muze navzdory uzivani Indonalu progredovat) … I3C v tom ale nebude hrat onu „zhorsujici“ roli!

pri doporuceni uzivani Indonalu v ramci HPV infekce je jiste mnohem vyhodnejsi, budou-li jej uzivat oba (vsichni) sexualni partneri.

Dobry den, mohu pouzivat soucasne Indonal Partner s Wobenzynem a Betaglucanem? Jsem po konikaci, HPV tet. T

Novex Brazilian Keratin Deep Conditioning Treatment, Novex

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Mani Monday: Crazy For Color

Make your nails stand out by painting each one with a different color. We went bold for spring. Starting with the thumb, we used Nina Ultra Pro Ocean View, China Glaze Spontaneous, OPI I Just Can’t Cope-Acabana, FingerPaints A-Cry-Lic A Girl and China Glaze Four Leaf Clover. Let your nails dry completely.

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Brazilian Keratin Deep Conditioning Treatment

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Novex Brazilian Keratin is enriched with Vitamin E and the most genuine Brazilian Keratin. Keratin is a substance that reinforces the structure of the hair, increasing shine and leaving hair healthy, manageable and soft to the touch. The Brazilian Keratin is hydrolyzed, which guarantees fast absorption by the hair fibers.

Wash your hair with Novex Shampoo and remove excess of water.

Apply Novex Brazilian Keratin Deep Conditioning Treatment, massage gently and leave it on for 15 minutes. Rinse well and remove excess if water.

Finish as desired. (Natural, blow dried ir flat ironed.)

Also use as a Conditioner with 3 minutes application for a daily care.

Aqua, CetearylAlcohol, Petrolatum, Hydrolyzed Keratin, Zea Mays Starch, Cetrimonium Chloride, Parfum, Phenyl Trimethicone, Methylparaben, Propylparaben, Lactic Acid, Tocopheryl Acetate, Methylisothiazolinone, Methylchloroisothiazolinone.

Additional Information on recomended and recently viewd prods

Eurocefix Capsules, Eurocefix

Eurocefix Capsules

Alta Care Laboratoires offers a wide range of products which includes eurocefix capsules. Components: 8 capsules. Active ingredient (inn): cefaclor monohydrate 500mg. Doses, directions and administration: it is administered orally and can be administered independently without meals. Adults: 250mg every 8 hours. For more severe infections doses may be increased. The maximum recommended dose is of 2g a day. For the treatment of acute urethritis gonococcus in both sexes, a unique administration of cefaclor 3g eventually combined to 1g of probenecid is advisable. Children: 20 mg/kg/day in divided doses every 8 hours: in more serious infections, otitis media,40 mg/kg/day are recommended, with a maximum dosage of 1 g/day. Treatment option: for the treatment of otitis media and pharyngitis, the total daily dosage may be divided and administered every 12 hours; the dosage should be as follow. Up to 8 kg syringe from 8 to 16 kg syringe or meter from 16 to 21 kg meter over 21 kg meter 2 times the (unitary dose) 150mg (3ml) 300mg (6ml) 400mg (8ml) 500mg (10ml). Contact us for more information.

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Placid - Definition Of Placid By The Free Dictionary, Pacid

placid

placid

[ˈplæsɪd] adj → placido/a, calmo/a

placid

calm and not easily disturbed or upset. a placid child. vreedsaam, kalm ????? ????? спокоен placido klidny, mirny ruhig fredsommelig ?????? placido rahulik ??????? ???? tyyni placide ???? ????? miran, spokojan bekes tenang rolegur, stilltur placido ????? ??? ramus rams tenang rustig rolig. stillferdig pogodny ????? ???? ???? ???? ???? ?????? ????? placido linistit спокойный mierny, spokojny miren miran lugn, mild, blid ??????? sakin ??? спокійний, безтурботний ????? ????? di?m tinh ???

vreedsaam ???????? ????????? спокойно placidamente klidne ruhig fredsommeligt ????? placidamente rahulikult ?? ??????? tyynesti placidement ?????????? ????? ??, ??????? ?? mirnoca, vedrina bekesen dengan tenang rolega placidamente ????? ???? ramiai rami dgn tenang rustig rolig. stillferdig pogodnie ?? ????? ?? ?? ???? ?? ??? ???? placidamente (cu) calm спокойно mierne, spokojne, nerusene spokojno mirno lugnt ???????????? sakin sakin ??? безтурботно ???? ?? m?t cach di?m tinh ???

vreedsaamheid ?????? ??????? кроткост placidez mirnost die Ruhe fredsommelighed ?????? placidez rahulikkus ????? tyyneys placidite ????? ???????, ????? spokoj, mir bekes volta vminek ketenangan rolegheit calma ????? ??? ramuma(s) ramums ketenangan rust stillferdighet. ro pogoda ducha ?????? placidez calm спокойствие miernost, spokojnost spokojnost mirnoca lugn, mildhet, blidhet ??????? sakinlik ?? безтурботність ???? ???? s? di?m tinh ??

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Jo was determined to have it out now, and tried to look quite placid. though she quaked a little after her bold speech.

She was very quiet but beneath a placid exterior a continual ferment went on.

See," he said, pointing through the trees toward a spot where a little basin of water reflected the stars from its placid bosom, "here is the 'bloody pond'; and I am on ground that I have not only often traveled, but over which I have fou't the enemy, from the rising to the setting sun.

What thanks, what ardent and ceaseless thanks are due to that all-superintending Providence which has turned a cruel war into peace, brought order out of confusion, made the fierce savages placid. and turned away their hostile weapons from our country

and she stood there with a plate in her hand, beaming at our companion, who looked from one of us to the other with placid heavenly eyes that contained nothing to check us.

For that strange spectacle observable in all sperm whales dying --the turning sunwards of the head, and so expiring --that strange spectacle, beheld of such a placid evening, somehow to Ahab conveyed a wondrousness unknown before.

The snowy fisse crape cap, made after the strait Quaker pattern,--the plain white muslin handkerchief, lying in placid folds across her bosom,--the drab shawl and dress,--showed at once the community to which she belonged.

and I looked around on the company with placid satisfaction, for I had slipped up on him gradually and tied him hand and foot, you see, without his ever noticing that he was being tied at all.

Hoch placid and content, Gretchen weeping over her hard fate.

Blake's dull face flushed under this gibe, but before he could set his retort in order Tom had turned to Wilson, and was saying, with placid indifference of manner and voice:

Rebecca flew down over the hill to get a last pail of spring water, and as she lifted the bucket from the crystal depths and looked out over the glowing beauty of the autumn landscape, she saw a company of surveyors with their instruments making calculations and laying lines that apparently crossed Sunnybrook at the favorite spot where Mirror Pool lay clear and placid. the yellow leaves on its surface no yellower than its sparkling sands.

April advanced to May: a bright serene May it was; days of blue sky, placid sunshine, and soft western or southern gales filled up its duration.

Buy Kefungin Ketoconazole Online Without Prescriptions, Kefungin

Nizoral is used for treating fungal infections. Nizoral is an azole antifungal. It kills sensitive fungi by interfering with the formation of the fungal cell membrane.

Use Nizoral as directed by your doctor!

Take Nizoral by mouth with or without food.

Do not take an antacid within 1 hour before or 2 hours after you take Nizoral.

If you are also taking an anticholinergic (eg, hyoscyamine), an H 2 antagonist (eg, famotidine), or a proton pump inhibitor (eg, omeprazole), take Nizoral at least 2 hours before the H 2 antagonist, proton pump inhibitor, or anticholinergic.

To clear up your infection completely, take Nizoral for the full course of treatment. Keep taking it even if you feel better in a few days.

Nizoral works best if it is taken at the same time each day.

If you miss a dose of Nizoral, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Nizoral.

Store Nizoral between 59 and 77 degrees F (15 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Nizoral out of the reach of children and away from pets.

Active Ingredient: Ketoconazole.

Do NOT use Nizoral if:

you are allergic to any ingredient in Nizoral

you have a fungal infection in the brain membranes (fungal meningitis)

you are taking an aldosterone blocker (eg, eplerenone), astemizole, cisapride, conivaptan, dofetilide, an ergot alkaloid (eg, ergotamine), erythromycin, midazolam, nevirapine, pimozide, a quinazoline (eg, alfuzosin), quinidine, rifabutin, rifampin, terfenadine, triazolam, or a 5-HT receptor agonist (eg, eletriptan).

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Nizoral. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you are allergic to other azole antifungals (eg, itraconazole)

if you have low stomach acid (eg, hypochlorhydria)

if you have a history of liver disease, regular alcohol use, alcohol abuse or dependence, or blood problems (eg, prophyria).

Some medicines may interact with Nizoral. Tell your health care provider if you are taking any other medicines, especially any of the following:

Many prescription and nonprescription medicines (eg, used for infections, HIV, seizures, anxiety, sleep, heartburn, diabetes, high cholesterol, heart problems, high blood pressure, allergies, irregular heartbeat, pain, blood thinning, asthma, migraines, mood or mental problems, cancer, prostate problems, immune system suppression, erectile dysfunction, urinary problems, or contraception [birth control]), multivitamin products, and herbal or dietary supplements may interact with Nizoral, increasing the risk of serious side effects

Nevirapine, rifabutin, or rifampin because they may decrease Nizoral's effectiveness

Astemizole, cisapride, dofetilide, erythromycin, pimozide, quinidine, or terfenadine because the risk of severe heart effects may be increased

Midazolam or triazolam because their actions and the risk of their side effects may be increased by Nizoral, resulting in increased risk of sedation and breathing difficulties

Aldosterone blockers (eg, eplerenone), conivaptan, ergot alkaloids (eg, ergotamine), quinazolines (eg, alfuzosin) or 5-HT receptor agonists (eg, eletriptan) because the risk of their side effects may be increased by Nizoral.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Nizoral may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Nizoral may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Nizoral with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Rarely, Nizoral may cause a severe allergic reaction right after you take the first dose. Symptoms may include difficulty breathing; tightness in the chest; swelling of the eyelids, face, or lips; or rash or hives. If this happens, seek medical care at once.

Use of alcohol with Nizoral has rarely caused symptoms such as flushing, rash, swelling of the hands and feet, nausea, and headache. Talk with your doctor before drinking alcohol while taking Nizoral.

Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.

Nizoral only works against fungi; it does not treat viral infections (eg, the common cold) or bacterial infections.

Be sure to use Nizoral for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The infection could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.

Diabetes patients - Nizoral may increase the risk of low blood sugar from your diabetes medicine. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

Hormonal birth control (eg, birth control pills) may not work as well while you are using Nizoral. To prevent pregnancy, use an extra form of birth control (eg, condoms).

Lab tests, including liver function tests, may be performed while you use Nizoral. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Nizoral should be used with extreme caution in children; safety and effectiveness in children have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Nizoral while you are pregnant. Nizoral is found in breast milk. Do not breastfeed while using Nizoral.

Oracea Side Effects In Detail, Oracea

Oracea Side Effects

Note: This page contains side effects data for the generic drug doxycycline. It is possible that some of the dosage forms included below may not apply to the brand name Oracea.

For the Consumer

Applies to doxycycline: oral capsule, oral capsule delayed release, oral capsule extended release, oral powder for suspension, oral syrup, oral tablet, oral tablet delayed release

Other dosage forms:

As well as its needed effects, doxycycline (the active ingredient contained in Oracea) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking doxycycline, check with your doctor immediately:

Incidence not known:

Abdominal or stomach tenderness

bloating

clay-colored stools

cough

dark urine

decreased appetite

diarrhea

diarrhea, watery and severe, which may also be bloody

difficulty with swallowing

dizziness

fast heartbeat

feeling of discomfort

fever

headache

hives, itching, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

hives or welts, itching, or rash

increased thirst

inflammation of the joints

joint or muscle pain

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

loss of appetite

nausea and vomiting

numbness or tingling of the face, hands, or feet

pain

redness and soreness of the eyes

redness of the skin

sore throat

sores in the mouth

stomach cramps

stomach pain or tenderness

swelling of the feet or lower legs

swollen lymph glands

tightness in the chest

unusual tiredness or weakness

unusual weight loss

yellow eyes or skin

Minor Side Effects

Some doxycycline side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Incidence not known:

Back, leg, or stomach pains

black, tarry stools

bleeding gums

blood in the urine or stools

blurred vision

bulging soft spot on the head of an infant

change in the ability to see colors, especially blue or yellow

chest pain, discomfort, or burning

chills

cracks in the skin

decrease in vision

difficulty breathing

discoloration of the thyroid glands

double vision

general body swelling

heartburn

increased sensitivity of the skin to sunlight

loss of heat from the body

lower back or side pain

nosebleeds

pain or burning in the throat

pain with swallowing

painful or difficult urination

pale skin

pinpoint red spots on the skin

rash with flat lesions or small raised lesions on the skin

red, swollen skin

redness or other discoloration of the skin

redness, swelling, or soreness of the tongue

scaly skin

severe nausea

severe stomach pain

severe sunburn

sores, ulcers, or white spots on the lips or tongue or inside the mouth

unusual bleeding or bruising

vomiting blood

For Healthcare Professionals

Applies to doxycycline: injectable powder for injection, oral capsule, oral delayed release capsule, oral delayed release tablet, oral kit, oral powder for reconstitution, oral syrup, oral tablet, oral and topical kit

Nervous system

Benign intracranial hypertension resulting in significant loss of vision has been reported.

A 70-year-old female patient with no significant medical history suddenly developed a severe headache followed by vomiting about 15 minutes after the initial dose of doxycycline (the active ingredient contained in Oracea) The patient also experienced memory dysfunction; she could not remember the events of the afternoon prior to the doxycycline dose and could not retain the information after she was reminded. The incident lasted about 30 minutes and she was transported to the hospital for further evaluation. No further cause, such as intoxication or trauma, could be elicited. Once at the hospital, the patient was able to remember the events of the afternoon and could retain new information, but amnesia regarding the events of the 30 minutes following the onset of the headache persisted. The patient's laboratory results, CT scan, MRI scan, cerebrospinal fluid, and EEG showed no pathology. When the patient was discharged 2 days later, the amnesia for the 30 minutes continued. After elimination of other symptomatic causes, the amnesia was concluded to be due to the doxycycline because of the close relation of the doxycycline dose and the onset of symptoms. [Ref ]

Very common (10% or more): Headache (up to 26%) Frequency not reported: Sinus headache, dizziness, drowsiness, amnesia, paresthesias of body areas exposed to sunlight, phrenic nerve paralysis after sclerotherapy Postmarketing reports: Pseudotumor cerebri (benign intracranial hypertension), headache

Tetracyclines: Frequency not reported: Bulging fontanels in infants, benign intracranial hypertension (pseudotumor cerebri) in adults [Ref ]

Gastrointestinal

Very common (10% or more): Nausea (up to 13.4%) Common (1% to 10%): Vomiting (8.1%), toothache (7%), tooth disorder (6%), dyspepsia (6%), diarrhea (up to 6%), periodontal abscess (4%), acid indigestion (4%), upper abdominal pain (2%), abdominal distention (1%), abdominal pain (1%), stomach discomfort (1%), dry mouth (1%) Uncommon (0.1% to 1%): Gum pain (less than 1%) Rare (less than 0.1%): Adult tooth staining (at least 1 case) Frequency not reported: Clostridium difficile associated diarrhea, esophageal irritation, ulceration, epigastric burning, black hairy tongue

Tetracyclines: Frequency not reported: Nausea, vomiting, diarrhea, glossitis, dysphagia, enterocolitis, inflammatory lesions (with monilial overgrowth) in the anogenital region, esophagitis, esophageal ulcerations [Ref ]

Numerous cases of esophageal ulceration have been reported. In most of the cases the patients had taken their medication at bedtime, usually without enough liquid. Patients often present with severe retrosternal pain and difficulty swallowing. Ulcerations generally resolve within a week after discontinuation of the medication. One case report describes severe hiccups of 4-day duration associated with esophagitis following the first dose of doxycycline.

Esophagitis and esophageal ulcerations have been reported in patients receiving capsule and tablet formulations of tetracycline-class drugs. Most took medication immediately before going to bed. [Ref ]

Other

Very common (10% or more): Common cold (22%), influenza symptoms (11%) Common (1% to 10%): Injury (5%), pain (up to 4%), back pain (up to 3%), back ache (2%), infection (2%), fungal infection (2%), influenza (2%) Frequency not reported: Possible overgrowth of nonsusceptible organisms (superinfection)

Tetracyclines: Frequency not reported: Microscopic brown-black discoloration of the thyroid gland [Ref ]

The long-term use of tetracyclines has been associated with microscopic brown-black discoloration of the thyroid gland; abnormal thyroid function has not been reported. [Ref ]

Musculoskeletal

Common (1% to 10%): Joint pain (6%), muscle pain (1%)

Respiratory

Common (1% to 10%): Nasopharyngitis (5%), sore throat (5%), sinus congestion (5%), coughing (4%), sinus headache (up to 4%), sinusitis (3%), bronchitis (3%), nasal congestion (2%), pharyngolaryngeal pain (1%)

Dermatologic

Common (1% to 10%): Rash (4%) Frequency not reported: Nail discoloration, phototoxicity, photoallergic reaction, photo-onycholysis

Tetracyclines: Frequency not reported: Photosensitivity, maculopapular and erythematous rashes, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, exfoliative dermatitis, hyperpigmentation [Ref ]

In a double-blinded study, doxycycline was found to be more phototoxic than minocycline and demeclocycline. Paresthesias of the body areas exposed to sunlight may be early signs of sunburn reactions.

A case report of a possible photoallergic reaction describes scaly erythema and vesicles on the face and neck associated with doxycycline administration. Upon rechallenge, a flare with erythema, itching and burning occurred in the same area.

Another case report was documented in Australian troops treated with doxycycline 100 mg daily for malaria prophylaxis while on deployment in East Timor, a group of islands within the Malaysian archipelago located close to the equator. Of the 135 troops, 22 exhibited phototoxic reactions to low dosages of doxycycline that resembled severe sunburn with erythematous plaques on the sun-exposed areas. The troops used a sunscreen containing oxybenzone.

An 11-year-old boy treated with doxycycline for brucellosis was evaluated for painless brown nail discoloration. Doxycycline was initiated for brucellosis but stopped when the boy developed photosensitivity, but 15 days after the initiation of therapy brown nail discoloration developed. Other than the brown discoloration, the boy's physical condition was normal and the discoloration disappeared within one month. [Ref ]

Genitourinary

Common (1% to 10%): Menstrual cramp (4%), bacterial vaginitis (3.3%), vulvovaginal mycotic infection (2%) Frequency not reported: Vaginal itch

Tetracyclines: Frequency not reported: Vaginal candidiasis [Ref ]

Cardiovascular

Common (1% to 10%): Hypertension (3%), increased blood pressure (2%)

Hepatic

Common (1% to 10%): Increased aspartate aminotransferase (2%) Frequency not reported: Acute hepatocellular injury, cholestatic reactions

Tetracyclines: Frequency not reported: Hepatotoxicity [Ref ]

Metabolic

Hypoglycemia in a nondiabetic patient has been reported. [Ref ]

Common (1% to 10%): Increased blood lactate dehydrogenase (2%), increased blood glucose (1%) Frequency not reported: Hypoglycemia

Tetracyclines: Frequency not reported: Anorexia [Ref ]

Psychiatric

Common (1% to 10%): Anxiety (2%)

Hypersensitivity

Tetracyclines: Frequency not reported: Hypersensitivity reactions (including urticaria, angioneurotic edema, anaphylaxis, anaphylactoid purpura, serum sickness, pericarditis, exacerbation of systemic lupus erythematosus, drug rash with eosinophilia and systemic symptoms [DRESS]) [Ref ]

Hematologic

Tetracyclines: Frequency not reported: Hemolytic anemia, thrombocytopenia, neutropenia, eosinophilia [Ref ]

Ocular

Frequency not reported: Diplopia, papilledema, loss of vision (associated with doxycycline-induced benign intracranial hypertension) [Ref ]

Renal

Tetracyclines: Frequency not reported: Dose-related rise in BUN [Ref ]

Immunologic

Tetracyclines: Frequency not reported: Autoimmune syndromes

References

1. Tabibian JH, Gutierrez MA "Doxycycline-induced pseudotumor cerebri." South Med J 102 (2009): 310-1

2. Digre KB "Not so benign intracranial hypertension." BMJ 326 (2003): 613-4

3. Kirse DJ, Suen JY, Stern SJ "Phrenic nerve paralysis after doxycycline sclerotherapy for chylous fistula." Otolaryngol Head Neck Surg 116 (1997): 680-3

4. Del Rosso JQ, Webster GF, Jackson M, et al. "Two randomized phase III clinical trials evaluating anti-inflammatory dose doxycycline (40-mg doxycycline, USP capsules) administered once daily for treatment of rosacea." J Am Acad Dermatol 56 (2007): 791-802

5. Heveling T, Kubalek R "Doxycycline-induced amnesia. a case report." Eur J Clin Pharmacol 63 (2006): 95-6

6. "Product Information. Acticlate (doxycycline)." Aqua Pharmaceuticals LLC, Malvern, PA.

7. Hasin T, Davidovitch N, Cohen R, et al. "Postexposure treatment with doxycycline for the prevention of tick-borne relapsing fever." N Engl J Med 355 (2006): 148-55

8. Friedman DI, Gordon LK, Egan RA, et al. "Doxycycline and intracranial hypertension." Neurology 62 (2004): 2297-9

9. "Product Information. Adoxa (doxycycline)." Doak Dermatologics Division, Fairfield, NJ.

10. Amendola MA, Spera TD "Doxycycline-induced esophagitis." JAMA 253 (1985): 1009-11

11. Akhyani M, Ehsani AH, Ghiasi M, Jafari AK "Comparison of efficacy of azithromycin vs. doxycycline in the treatment of rosacea: a randomized open clinical trial." Int J Dermatol 47 (2008): 284-8

12. Tzianetas I, Habal F, Keystone JS "Short report: severe hiccups secondary to doxycycline-induced esophagitis during treatment of malaria." Am J Trop Med Hyg 54 (1996): 203-4

13. Story MJ, McCloud PI, Boehm G "Doxycycline tolerance study: incidence of nausea after doxycycline administration to healthy volunteers: a comparison of 2 formulations (Doryx' vs vibramycin')." Eur J Clin Pharmacol 40 (1991): 419-21

14. Aarons B, Bruns BJ "Oesophageal ulceration associated with ingestion of doxycycline." N Z Med J 91 (1980): 27

15. de Vries HJ, Smelov V, Middelburg JG, Pleijster J, Speksnijder AG, Morre SA "Delayed microbial cure of lymphogranuloma venereum proctitis with doxycycline treatment." Clin Infect Dis 48 (2009): e53-6

16. Grochenig HP, Tilg H, Vogetseder W "Clinical challenges and images in GI. Pill esophagitis." Gastroenterology 131 (2006): 996, 1365

17. Freedman DO "Clinical practice. Malaria prevention in short-term travelers." N Engl J Med 359 (2008): 603-12

18. Geschwind A "Oesophagitis and oesophageal ulceration following ingestion of doxycycline tablets." Med J Aust 140 (1984): 223

19. "Product Information. Periostat (doxycycline)" Collagenex Pharmaceuticals, Newtown, PA.

20. Golledge CL, Riley TV "Clostridium difficile-associated diarrhoea after doxycycline malaria prophylaxis." Lancet 345 (1995): 1377-8

21. Ramsakal A, Mangat L "Images in clinical medicine. Lingua villosa nigra." N Engl J Med 357 (2007): 2388

22. "Product Information. Oracea (doxycycline)." Collagenex Pharmaceuticals, Newtown, PA.

23. Nelson R, Parker SR "Doxycycline-induced staining of adult teeth: the first reported case." Arch Dermatol 142 (2006): 1081-2

24. Foster JA, Sylvia LM "Doxycyline-induced esophageal ulceration." Ann Pharmacother 28 (1994): 1185-7

25. Wormser GP "Clinical practice. Early Lyme disease." N Engl J Med 354 (2006): 2794-801

26. "Low-Dose Doxycycline (Oracea) for Rosacea." Med Lett Drugs Ther 49 (2007): 5-6

27. Croft AM, Jackson CJ, Darbyshire AH "Doxycycline for the prevention of tick-borne relapsing fever." N Engl J Med 355 (2006): 1614; author reply 1614-5

28. Adverse Drug Reactions Advisory Committee "Doxycycline-induced oesophageal ulceration." Med J Aust 161 (1994): 490

29. "Product Information. Vibramycin (doxycycline)." Pfizer US Pharmaceuticals, New York, NY.

30. Hasanjani Roushan MR, Mohraz M, Hajiahmadi M, Ramzani A, Valayati AA "Efficacy of Gentamicin plus Doxycycline versus Streptomycin plus Doxycycline in the Treatment of Brucellosis in Humans." Clin Infect Dis 42 (2006): 1075-80

31. Smith K, Leyden JJ "Safety of doxycycline and minocycline: a systematic review." Clin Ther 27 (2005): 1329-42

32. Passier A, Smits-van Herwaarden A, van Puijenbroek E "Photo-onycholysis associated with the use of doxycycline." BMJ 329 (2004): 265

33. Frost P, Weinstein GD, Gomez EC "Phototoxic potential of minocycline and doxycycline." Arch Dermatol 105 (1972): 681-3

34. Lim DS, Murphy GM "High-level ultraviolet A photoprotection is needed to prevent doxycycline phototoxicity: lessons learned in East Timor." Br J Dermatol 149 (2003): 213-4

35. Tanaka N, Kawada A, Ohnishi Y, Hiruma M, Tajima S, Akiyama M, Ishibashi A "Photosensitivity due to doxycycline hydrochloride with an unusual flare." Contact Dermatitis 37 (1997): 93-4

36. Akcam M, Artan R, Akcam FZ, Yilmaz A "Nail discoloration induced by doxycycline." Pediatr Infect Dis J 24 (2005): 845-846

37. Curley RK, Verbov JL "Stevens-Johnson syndrome due to tetracyclines: a case report (doxycycline) and review of the literature." Clin Exp Dermatol 12 (1987): 124-5

38. Lewis-Jones MS, Evans S, Thompson CM "Erythema multiforme occurring in association with lupus erythematosus during therapy with doxycycline." Clin Exp Dermatol 13 (1988): 245-7

39. Habif TP "Images in clinical medicine. Doxycycline-induced phototoxicity." N Engl J Med 355 (2006): 182

40. Bjornsson E, Lindberg J, Olsson R "Liver reactions to oral low-dose tetracyclines." Scand J Gastroenterol 32 (1997): 390-5

41. Basaria S, Braga M, Moore WT "Doxycycline-induced hypoglycemia in a nondiabetic young man." South Med J 95 (2002): 1353-4

42. Raeder JC "Anaphylactoid reaction caused by intravenous doxycycline during general anesthesia and beta-blockade treatment." Drug Intell Clin Pharm 18 (1984): 481-2

43. Lochhead J, Elston JS "Doxycycline induced intracranial hypertension." BMJ 326 (2003): 641-2

44. Chan AY, Liu DT, Friedman DI, Gordon LK, Egan RA "Doxycycline and intracranial hypertension." Neurology 64 (2005): 765-6

It is possible that some side effects of Oracea may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Ftizopiram - (Phthizopiram), Tab, Phthizopiram

ФТИЗОПИРАМ® (PHTHIZOPIRAM)

Торговое название: ФТИЗОПИРАМ® (PHTHIZOPIRAM) (расширенная инструкция) (аналоги и цены)

Активное вещество: пиразинамид (pyrazinamide)

Международное непатентованное название: Rec. INN / зарегистрированное ВОЗ

Форма выпуска: таб. 150 мг+500 мг: 50 или 100 шт.

ATX: J04AC51 (Изониазид в комбинации с другими препаратами)

Фармакологическая группа: Противотуберкулезное комбинированное средство

Клиническая группа: Противотуберкулезный препарат

Регистрационный номер: Р N003731/01

Дата регистрации: 2009-10-16 05:40:07

Статус регистрации: Срок действия рег. уд. не ограничен

Отпуск: По рецепту

Владелец регистрационного удостоверения: Химико-фармацевтический комбинат АКРИХИН, ОАО (Россия)

Представительство: АКРИХИН ОАО (Россия)

Вспомогательные вещества . крахмал картофельный - 22 мг, карбоксиметилкрахмал натрия - 7 мг, стеариновая кислота - 7 мг, кремния диоксид коллоидный - 7 мг, тальк - 7 мг.

10 шт. - упаковки контурные ячейковые (5) - пачки картонные. 10 шт. - упаковки контурные ячейковые (10) - пачки картонные. 50 шт. - банки полипропиленовые (1) - пачки картонные. 100 шт. - банки полипропиленовые (1) - пачки картонные. 50 шт. - банки полиэтиленовые (1) - пачки картонные. 100 шт. - банки полиэтиленовые (1) - пачки картонные.

— лечение туберкулеза, вызванного чувствительными микобактериями к изониазиду и пиразинамиду (всех форм и локализаций).

Препарат Фтизопирам применяется внутрь после еды, 1 раз/сут. Дозирование Фтизопирама проводится по изониазиду из расчета 5-10 мг/кг массы больного.

Препарат применяется ежедневно в период интенсивной терапии (3-4 мес), в последующее время - через день. Общая курсовая доза Фтизопирама для каждого больного индивидуальна и зависит от характера заболевания, эффективности лечения и переносимости.

Со стороны гепато-билиарной системы: может отмечаться нарушение функции печени, особенно у пациентов с гипотрофией или предшествующими заболеваниями печени, а также у пациентов пожилого возраста.

Со стороны ЖКТ: тошнота, рвота, диарея, боли в животе.

Со стороны нервной системы: головная боль, головокружение, редко - раздражительность, эйфория, бессонница, психозы. Иногда возможно развитие периферической нейропатии, особенно у пожилых пациентов, беременных женщин, пациентов с гипотрофией, больных сахарным диабетом, а также у пациентов с хроническими заболеваниями печени, в том числе, алкогольной этиологии. Для профилактики периферической нейропатии рекомендуется принимать пиридоксин. У больных эпилепсией могут учащаться припадки.

Со стороны сердечно-сосудистой системы: сердцебиение, стенокардия, повышение АД.

Аллергические реакции: кожная сыпь, зуд.

Прочие: очень редко - гинекомастия, меноррагия.

Со стороны гепато-билиарной системы: реакции со стороны печени варьируют от бессимптомного нарушения функции печеночных клеток, выявляемого только с помощью лабораторных методов, до тяжелого нарушения функции печени, проявляющегося желтухой. Эти побочные эффекты обычно не возникают при приеме пиразинамида в дозах, не превышающих 25 мг/кг массы тела в сутки; добавление пиразинамида к рифампицину и изониазиду не приводит к увеличению общей частоты токсического поражения печени.

Со стороны пищеварительной системы: могут отмечаться снижение аппетита, тошнота, рвота, диарея, "металлический" привкус во рту, обострение пептической язвы.

Со стороны ЦНС: головокружение, головная боль, нарушения сна, повышенная возбудимость, депрессии; в отдельных случаях - галлюцинации, судороги, спутанность сознания.

Со стороны органов кроветворения и системы гемостаза: тромбоцитопения, сидеробластная анемия, вакуолизация эритроцитов, порфирия, повышение свертывания крови, спленомегалия.

Со стороны опорно-двигательного аппарата: артралгия, миалгия.

Со стороны мочевыделительной системы: дизурия, интерстициальный нефрит.

Аллергические реакции: кожная сыпь, крапивница, фотосенсибилизация.

Прочие: гипертермия, акне, гиперурикемия, повышение концентрации сывороточного железа. Может развиваться подагрический артрит.

Противопоказания к применению

Фтизопирам противопоказан пациентам:

— с гиперчувствительностью к изониазиду и пиразинамиду;

— при эпилепсии и других заболеваниях, сопровождающихся склонностью к судорогам;

— неконтролируемой артериальной гипертензии;

— тяжелой коронарной недостаточности;

— циррозе печени;

— острых гепатитах;

— язвенной болезни желудка и двенадцатиперстной кишки;

— бронхиальной астме;

— беременности и в период лактации.

С осторожностью назначать препарат лицам с хронической почечной недостаточностью.

Фтизопирам может оказывать гепатотоксическое действие, поэтому его следует применять с осторожностью у пациентов с нарушением функции печени, у лиц, страдающих хроническим алкоголизмом, а также у пациентов с гипотрофией.

Применение при беременности и кормлении грудью

В период беременности Фтизопирам назначают только по жизненным показаниям. Изониазид и пиразинамид выделяются с грудным молоком. Женщинам, принимающим Фтизопирам, нельзя кормить ребенка грудью.

Применение при нарушениях функции печени

Фтизопирам может оказывать гепатотоксическое действие, поэтому его следует применять с осторожностью у пациентов с нарушением функции печени, у лиц, страдающих хроническим алкоголизмом.

Применение при нарушениях функции почек

С осторожностью назначать препарат лицам с хронической почечной недостаточностью.

Во время лечения препаратом пациенты должны воздерживаться от приема алкоголя.

При длительной терапии, а также у пациентов с нарушением функции печени рекомендуется регулярно контролировать общий анализ крови и показатели функции печени.

Для профилактики и лечения периферической невропатии, которая может развиваться на фоне терапии изониазидом, рекомендуется дополнительное назначение пиридоксина (витамина В 6 ).

В ряде случаев, особенно у пациентов с приступами подагры в анамнезе, рекомендуется периодически контролировать уровень мочевой кислоты в сыворотке крови.

При назначении пиразинамида пациентам с гипопластической анемией следует учитывать влияние препарата на время свертывания крови.

Рекомендуется контролировать активность АЛТ и ACT в плазме и ежемесячно оценивать функцию печени. Изониазид следует отменять только в тех случаях, если уровни трансаминаз более чем в 3 раза превышают ВГН, поскольку нередко отмечается бессимптомное преходящее повышение уровня печеночных ферментов, которое не требует прекращения приема препарата. При развитии острого или хронического гепатита изониазид необходимо отменить, в последнем случае возобновлять терапию изониазидом нельзя.

При приеме в высоких дозах возможно развитие побочных реакций со стороны нервной системы (периферическая невропатия), что влияет на способность к управлению автомобилем и на работу со сложным оборудованием.

Симптомы передозировки: тошнота, рвота, боли в животе, желтуха, повышение уровня печеночных ферментов, острый отек легких, нарушение сознания, коматозное состояние, судороги, нарушение дыхания, гипергликемия, метаболический кетоацидоз.

Лечение: промывание желудка с введением внутрь активированного угля, форсированный диурез, общие меры по поддержанию жизненно важных функций, гемодиализ.

Изониазид замедляет метаболизм некоторых лекарственных препаратов, включая фенитоин, карбамазепин, вальпроат. При одновременном назначении с изониазидом дозы указанных препаратов рекомендуется снижать.

Следует избегать одновременного применения изониазида и дисульфирама, так как это может приводить к психическим расстройствам. Механизм этого взаимодействия не установлен.

Изониазид повышает сывороточные концентрации карбамазепина и фенитоина, снижает концентрацию в крови кетоконазола и циклоспорина.

Антациды уменьшают абсорбцию изониазида.

Снижает эффективность пероральных контрацептивных препаратов, глипизида, толбутамида, теофиллина, толазомида, витамина В 1 ; усиливает побочные действия фенитоина; подавляет выведение триазолама, усиливает экскрецию витамина В 1 ; снижает содержание ионов цинка в крови, увеличивает их экскрецию.

Употребление алкоголя на фоне терапии изониазидом может повышать риск возникновения гепатита.

Пиразинамид может повышать концентрации мочевой кислоты в сыворотке крови и снижать эффективность препаратов для лечения подагры, таких как аллопуринол, колхицин, пробеницид, сульфинпиразон. В подобных случаях может потребоваться увеличение дозы противоподагрических средств.

При одновременном применении с пиразинамидом концентрации в крови и эффективность циклоспорина могут снижаться.

Условия отпуска из аптек

Препарат отпускается по рецепту.

Условия и сроки хранения

Список Б. В сухом, защищенном от света месте, при температуре не выше 25°С. Хранить в недоступном для детей месте.

Срок годности 2 года 6 мес. Не использовать после истечения срока годности, указанного на упаковке.

ФТИЗОПИРАМ® (PHTHIZOPIRAM)

Торговое название: ФТИЗОПИРАМ® (PHTHIZOPIRAM) (расширенная инструкция) (аналоги и цены)

Активное вещество: пиразинамид (pyrazinamide)

Международное непатентованное название: Rec. INN / зарегистрированное ВОЗ

Форма выпуска: таб. 150 мг+500 мг: 50 или 100 шт.

ATX: J04AC51 (Изониазид в комбинации с другими препаратами)

Фармакологическая группа: Противотуберкулезное комбинированное средство

Клиническая группа: Противотуберкулезный препарат

Регистрационный номер: Р N003731/01

Дата регистрации: 2009-10-16 05:40:07

Статус регистрации: Срок действия рег. уд. не ограничен

Отпуск: По рецепту

Владелец регистрационного удостоверения: Химико-фармацевтический комбинат АКРИХИН, ОАО (Россия)

Представительство: АКРИХИН ОАО (Россия)

Вспомогательные вещества . крахмал картофельный - 22 мг, карбоксиметилкрахмал натрия - 7 мг, стеариновая кислота - 7 мг, кремния диоксид коллоидный - 7 мг, тальк - 7 мг.

10 шт. - упаковки контурные ячейковые (5) - пачки картонные. 10 шт. - упаковки контурные ячейковые (10) - пачки картонные. 50 шт. - банки полипропиленовые (1) - пачки картонные. 100 шт. - банки полипропиленовые (1) - пачки картонные. 50 шт. - банки полиэтиленовые (1) - пачки картонные. 100 шт. - банки полиэтиленовые (1) - пачки картонные.

— лечение туберкулеза, вызванного чувствительными микобактериями к изониазиду и пиразинамиду (всех форм и локализаций).

Препарат Фтизопирам применяется внутрь после еды, 1 раз/сут. Дозирование Фтизопирама проводится по изониазиду из расчета 5-10 мг/кг массы больного.

Препарат применяется ежедневно в период интенсивной терапии (3-4 мес), в последующее время - через день. Общая курсовая доза Фтизопирама для каждого больного индивидуальна и зависит от характера заболевания, эффективности лечения и переносимости.

Со стороны гепато-билиарной системы: может отмечаться нарушение функции печени, особенно у пациентов с гипотрофией или предшествующими заболеваниями печени, а также у пациентов пожилого возраста.

Со стороны ЖКТ: тошнота, рвота, диарея, боли в животе.

Со стороны нервной системы: головная боль, головокружение, редко - раздражительность, эйфория, бессонница, психозы. Иногда возможно развитие периферической нейропатии, особенно у пожилых пациентов, беременных женщин, пациентов с гипотрофией, больных сахарным диабетом, а также у пациентов с хроническими заболеваниями печени, в том числе, алкогольной этиологии. Для профилактики периферической нейропатии рекомендуется принимать пиридоксин. У больных эпилепсией могут учащаться припадки.

Со стороны сердечно-сосудистой системы: сердцебиение, стенокардия, повышение АД.

Аллергические реакции: кожная сыпь, зуд.

Прочие: очень редко - гинекомастия, меноррагия.

Со стороны гепато-билиарной системы: реакции со стороны печени варьируют от бессимптомного нарушения функции печеночных клеток, выявляемого только с помощью лабораторных методов, до тяжелого нарушения функции печени, проявляющегося желтухой. Эти побочные эффекты обычно не возникают при приеме пиразинамида в дозах, не превышающих 25 мг/кг массы тела в сутки; добавление пиразинамида к рифампицину и изониазиду не приводит к увеличению общей частоты токсического поражения печени.

Со стороны пищеварительной системы: могут отмечаться снижение аппетита, тошнота, рвота, диарея, "металлический" привкус во рту, обострение пептической язвы.

Со стороны ЦНС: головокружение, головная боль, нарушения сна, повышенная возбудимость, депрессии; в отдельных случаях - галлюцинации, судороги, спутанность сознания.

Со стороны органов кроветворения и системы гемостаза: тромбоцитопения, сидеробластная анемия, вакуолизация эритроцитов, порфирия, повышение свертывания крови, спленомегалия.

Со стороны опорно-двигательного аппарата: артралгия, миалгия.

Со стороны мочевыделительной системы: дизурия, интерстициальный нефрит.

Аллергические реакции: кожная сыпь, крапивница, фотосенсибилизация.

Прочие: гипертермия, акне, гиперурикемия, повышение концентрации сывороточного железа. Может развиваться подагрический артрит.

Противопоказания к применению

Фтизопирам противопоказан пациентам:

— с гиперчувствительностью к изониазиду и пиразинамиду;

— при эпилепсии и других заболеваниях, сопровождающихся склонностью к судорогам;

— неконтролируемой артериальной гипертензии;

— тяжелой коронарной недостаточности;

— циррозе печени;

— острых гепатитах;

— язвенной болезни желудка и двенадцатиперстной кишки;

— бронхиальной астме;

— беременности и в период лактации.

С осторожностью назначать препарат лицам с хронической почечной недостаточностью.

Фтизопирам может оказывать гепатотоксическое действие, поэтому его следует применять с осторожностью у пациентов с нарушением функции печени, у лиц, страдающих хроническим алкоголизмом, а также у пациентов с гипотрофией.

Применение при беременности и кормлении грудью

В период беременности Фтизопирам назначают только по жизненным показаниям. Изониазид и пиразинамид выделяются с грудным молоком. Женщинам, принимающим Фтизопирам, нельзя кормить ребенка грудью.

Применение при нарушениях функции печени

Фтизопирам может оказывать гепатотоксическое действие, поэтому его следует применять с осторожностью у пациентов с нарушением функции печени, у лиц, страдающих хроническим алкоголизмом.

Применение при нарушениях функции почек

С осторожностью назначать препарат лицам с хронической почечной недостаточностью.

Во время лечения препаратом пациенты должны воздерживаться от приема алкоголя.

При длительной терапии, а также у пациентов с нарушением функции печени рекомендуется регулярно контролировать общий анализ крови и показатели функции печени.

Для профилактики и лечения периферической невропатии, которая может развиваться на фоне терапии изониазидом, рекомендуется дополнительное назначение пиридоксина (витамина В 6 ).

В ряде случаев, особенно у пациентов с приступами подагры в анамнезе, рекомендуется периодически контролировать уровень мочевой кислоты в сыворотке крови.

При назначении пиразинамида пациентам с гипопластической анемией следует учитывать влияние препарата на время свертывания крови.

Рекомендуется контролировать активность АЛТ и ACT в плазме и ежемесячно оценивать функцию печени. Изониазид следует отменять только в тех случаях, если уровни трансаминаз более чем в 3 раза превышают ВГН, поскольку нередко отмечается бессимптомное преходящее повышение уровня печеночных ферментов, которое не требует прекращения приема препарата. При развитии острого или хронического гепатита изониазид необходимо отменить, в последнем случае возобновлять терапию изониазидом нельзя.

При приеме в высоких дозах возможно развитие побочных реакций со стороны нервной системы (периферическая невропатия), что влияет на способность к управлению автомобилем и на работу со сложным оборудованием.

Симптомы передозировки: тошнота, рвота, боли в животе, желтуха, повышение уровня печеночных ферментов, острый отек легких, нарушение сознания, коматозное состояние, судороги, нарушение дыхания, гипергликемия, метаболический кетоацидоз.

Лечение: промывание желудка с введением внутрь активированного угля, форсированный диурез, общие меры по поддержанию жизненно важных функций, гемодиализ.

Изониазид замедляет метаболизм некоторых лекарственных препаратов, включая фенитоин, карбамазепин, вальпроат. При одновременном назначении с изониазидом дозы указанных препаратов рекомендуется снижать.

Следует избегать одновременного применения изониазида и дисульфирама, так как это может приводить к психическим расстройствам. Механизм этого взаимодействия не установлен.

Изониазид повышает сывороточные концентрации карбамазепина и фенитоина, снижает концентрацию в крови кетоконазола и циклоспорина.

Антациды уменьшают абсорбцию изониазида.

Снижает эффективность пероральных контрацептивных препаратов, глипизида, толбутамида, теофиллина, толазомида, витамина В 1 ; усиливает побочные действия фенитоина; подавляет выведение триазолама, усиливает экскрецию витамина В 1 ; снижает содержание ионов цинка в крови, увеличивает их экскрецию.

Употребление алкоголя на фоне терапии изониазидом может повышать риск возникновения гепатита.

Пиразинамид может повышать концентрации мочевой кислоты в сыворотке крови и снижать эффективность препаратов для лечения подагры, таких как аллопуринол, колхицин, пробеницид, сульфинпиразон. В подобных случаях может потребоваться увеличение дозы противоподагрических средств.

При одновременном применении с пиразинамидом концентрации в крови и эффективность циклоспорина могут снижаться.

Условия отпуска из аптек

Препарат отпускается по рецепту.

Условия и сроки хранения

Список Б. В сухом, защищенном от света месте, при температуре не выше 25°С. Хранить в недоступном для детей месте.

Срок годности 2 года 6 мес. Не использовать после истечения срока годности, указанного на упаковке.

Tamoxifen - Woman S Health, Tamoxis

Tamoxifen is used for treating breast cancer that has spread to other sites in the body. It is also used along with other medicines to treat other types of breast cancer. It is used in women who are at high risk of breast cancer and in women with DCIS (after surgery and radiation) to decrease the risk of developing breast cancer. It may also be used for other conditions as determined by your doctor.

Use Tamoxifen as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Tamoxifen comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Tamoxifen refilled.

Tamoxifen may be taken by mouth with or without food.

Take Tamoxifen with water or another nonalcoholic liquid.

Swallow this medication whole. Do not break, crush, or chew before swallowing.

Continue taking Tamoxifen even if you feel well. Do not miss any doses. Take Tamoxifen at the same time each day.

Drug Class and Mechanism

Tamoxifen is an antiestrogen. It works by blocking the effect of estrogen on certain tumors. This may prevent the growth of tumors that are activated by estrogen.

If you miss a dose of Tamoxifen, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Store Tamoxifen between 68 and 77 degrees F (20 and 25 degrees C) in a tightly closed, light-resistant container. Store away from moisture, heat, and light. Do not store in the bathroom. Do not take tablets after the expiration date printed on the label. Keep Tamoxifen out of the reach of children and away from pets.

Do NOT use Tamoxifen if: you are allergic to any ingredient in Tamoxifen you are using Tamoxifen to reduce your risk of breast cancer and you have a history of blood clots in the lung or leg you are using Tamoxifen to reduce your risk of breast cancer and you also take certain anticoagulants (eg, warfarin) you are taking anastrozole Some medical conditions may interact with Tamoxifen. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you: if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have a history of blood clots in the legs or lungs if you have high levels of calcium in your blood, a weakened immune system, or low levels of white blood cells or platelets in your blood if you have high cholesterol or lipid levels if you have cataracts or other vision problems if you are using cytotoxic cancer medicines if you are confined to a bed or chair

Possible Side Effects

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

bone pain; constipation; coughing; hot flashes; muscle pain; nausea; tiredness; vaginal discharge; weight loss.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unexplained hoarseness); abnormal menstrual periods; abnormal vaginal bleeding or bloody discharge; chest pain; coughing up blood; dark urine; decreased sexual desire or ability; depression; fever, chills, or persistent sore throat; groin or pelvic pain or pressure; loss of appetite; loss of balance or coordination; missed menstrual period; new or increased breast tumor or pain; new or unusual lumps; one-sided weakness; pain or swelling in one or both legs; red, swollen, blistered, or peeling skin; severe or persistent tiredness or weakness; shortness of breath; skin changes; stomach pain; sudden severe headache; swelling of the arms or the legs; unusual bleeding or bruising; vision or speech problems; yellowing of the eyes or skin.

If you have any questions about Tamoxifen. please talk with your doctor, pharmacist, or other health care provider. Tamoxifen is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor.

Tamoxifen is used for treating breast cancer that has spread to other sites in the body. It is also used along with other medicines to treat other types of breast cancer. It is used in women who are at high risk of breast cancer and in women with DCIS (after surgery and radiation) to decrease the risk of developing breast cancer. It may also be used for other conditions as determined by your doctor.

Use Tamoxifen as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Tamoxifen comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Tamoxifen refilled.

Tamoxifen may be taken by mouth with or without food.

Take Tamoxifen with water or another nonalcoholic liquid.

Swallow this medication whole. Do not break, crush, or chew before swallowing.

Continue taking Tamoxifen even if you feel well. Do not miss any doses. Take Tamoxifen at the same time each day.

Drug Class and Mechanism

Tamoxifen is an antiestrogen. It works by blocking the effect of estrogen on certain tumors. This may prevent the growth of tumors that are activated by estrogen.

If you miss a dose of Tamoxifen, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Store Tamoxifen between 68 and 77 degrees F (20 and 25 degrees C) in a tightly closed, light-resistant container. Store away from moisture, heat, and light. Do not store in the bathroom. Do not take tablets after the expiration date printed on the label. Keep Tamoxifen out of the reach of children and away from pets.

Do NOT use Tamoxifen if: you are allergic to any ingredient in Tamoxifen you are using Tamoxifen to reduce your risk of breast cancer and you have a history of blood clots in the lung or leg you are using Tamoxifen to reduce your risk of breast cancer and you also take certain anticoagulants (eg, warfarin) you are taking anastrozole Some medical conditions may interact with Tamoxifen. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you: if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have a history of blood clots in the legs or lungs if you have high levels of calcium in your blood, a weakened immune system, or low levels of white blood cells or platelets in your blood if you have high cholesterol or lipid levels if you have cataracts or other vision problems if you are using cytotoxic cancer medicines if you are confined to a bed or chair

Possible Side Effects

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

bone pain; constipation; coughing; hot flashes; muscle pain; nausea; tiredness; vaginal discharge; weight loss.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unexplained hoarseness); abnormal menstrual periods; abnormal vaginal bleeding or bloody discharge; chest pain; coughing up blood; dark urine; decreased sexual desire or ability; depression; fever, chills, or persistent sore throat; groin or pelvic pain or pressure; loss of appetite; loss of balance or coordination; missed menstrual period; new or increased breast tumor or pain; new or unusual lumps; one-sided weakness; pain or swelling in one or both legs; red, swollen, blistered, or peeling skin; severe or persistent tiredness or weakness; shortness of breath; skin changes; stomach pain; sudden severe headache; swelling of the arms or the legs; unusual bleeding or bruising; vision or speech problems; yellowing of the eyes or skin.

If you have any questions about Tamoxifen. please talk with your doctor, pharmacist, or other health care provider. Tamoxifen is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor.

Invader-Zidro (Invader Zidro), Zidro

This is the place where you can personalize your profile! But, how?

By moving, adding and personalizing widgets.

You can drag and drop to rearrange.

You can edit widgets to customize them.

The bottom has widgets you can add!

Some widgets you can only access when you get Core Membership.

Some widgets have options that are only available when you get Core Membership.

We've split the page into zones!

Certain widgets can only be added to certain zones.

"Why," you ask? Because we want profile pages to have freedom of customization, but also to have some consistency. This way, when anyone visits a deviant, they know they can always find the art in the top left, and personal info in the top right.

Don't forget, restraints can bring out the creativity in you!

Now go forth and astound us all with your devious profiles!

OK

Zidro

Newest Deviations

Stolen Hey guys, WeeGee2187 here! This is a blog I'm keeping, for a certain purpose. The purpose is for a game. A terrifying video game. It's been haunting me for over 7 months now, and it's getting on my nerves. Don't know what I'm talking about? Let me take you to the beggining. It all started at my favorite store, GameFly. Yes, The internet video game store, widly popular amongst geeks like me and my friends. I had heard about it through commercials that came on TV. Practicly all my friends were buzzing about it, so why not give it a try? I searched up, 'Pokemon'. Tons of results came up, and I chose 'Pokemon Platinum' which was fairly new at the time. It arrived 2 days later, in a large box. Wierd right? I opened the box and pulled out the game. It was beat up, and the cover was missing. "Of course, give me the damn beat up copy." I grumbled, putting the game in my DS. It loaded up, and the account saved on the game was 'Spice'. Spice nearly finished the game, and had last saved it som Stolen by Invader-Zidro

Invader Dib CHAPTER 2: Dib finally woke up. His back hurt BAD, and he also had a headache. "I really should learn not to mess with things." He told himself, standing up. He got out of the nursery, And looked for a way off of the planet. "How about. That Ship!!" Dib yelled, pointing to a large ship, Not realiizing it was The Massive's ship. He climbed in using a door on the side, and ran down a long hallway. At the end, was a retro-looking door. "I wonder what's going on in there. " Dib asked, listening to voices talk. "WELCOME TO THE IRKEN INVADER ASSIGNING. 2!!" Tallest Red yelled, smiling. "Today, We will assign 2 Invaders who missed the first assigning, A PLANET!" Tallest Purple yelled. "Now, BRING OUT THE LUCKY INVADERS!" Tallest Red commanded, pointing to the door Dib was behind. The door opened, and Dib tried to hide. "Hey, where's the other lucky Invader. " Tallest Purple asked, looking around. Suddenly, One of the Irkens pointed to where Dib was, and Dragged him out. "No, WAIT! YOU D Invader Dib by Invader-Zidro

Invader Dib CHAPTER 1: "ZIM! YOU WON'T GET AWAY WITH THIS!!" Dib yelled, strapped down in a chair. "I just did." Zim said, lowering a helmet over Dib's head. There was a huge, purple visor in front of it. "HAHAHAHAHA!!" Zim laughed, as Dib struggled to get free. "What is this going to do anyway??" Dib asked. "REMOVE YOUR BRAIN!!" Zim yelled, as he turned on the machine. Suddenly, GIR tripped over over the cord, And the machine shocked Dib. "OWWWW. THIS HURTS!!" Dib screamed, tugging at the helmet. Zim ran around franticly, pressing buttons. "This is not going as planned! GIR! YOUR RUINED MY PLAN!!" Zim yelled. Finnaly, The machine shut down, and Dib sat there, not moving. "It must have worked then. HAHAHAH!!" Zim laughed. GIR poked at Dib, until he twitched. "YAY!!" GIR yelled, poking Dib everywhere. "THE MISSION!!" Dib yeled, getting out of the seat. He stumbled on a cord and fell on the floor. "Oh well, I'll just put Dib in the Failed Experiment area." Zim said, dragging Dib. 2 Hours later, Invader Dib by Invader-Zidro

Clovate 0, Clovate

Clovate 0.5 mg/g Reviews: Unpopular Drug for Severe Skin Complaints

Country of Origin: India

Clovate (10, 30, or 50 gm) is a medication used to treat skin complaints like lichen sclerosis, psoriasis, discoid lupus erythematosus and eczema. This type of corticosteroid is effective at reducing redness and inflammation caused by certain chemicals in the body. It is manufactured by Dermocare Laboratories (Guj) Pvt. Ltd.

The active ingredient of Clobetasol is prescribed for short-term treatment and treats the more severe cases of skin disorders. This is a topical medication and used externally only. It shouldn’t be applied to the skin of those under 18-years-old. Make sure to carefully apply the cream and avoid contact with the nose, mouth, and eyes.

Clobetasol is able to function by working inside the cell walls to help slow the movement of certain inflammatory substances. By decreasing the release of these substances it is possible to prevent the unfortunate episodes of itching, redness, or swelling.

The active ingredient (Clobetasol) in Clovate is quite potent and should only be applied to the more serious skin complaints, such as psoriasis and eczema, which aren’t likely to respond to the low-strength medications.

The use of Clovate is limited to four week treatment periods. However, this time-frame is further shortened to five days if applying to a child’s skin or to the face. If signs of improvement aren’t noticed within a period of four weeks, make sure to discuss the matter with your doctor.

Clovate Reviews

We were unable to find reliable reviews or feedback from customers on the internet. Because of this lack of information, it might be more practical to look at close alternative medications that include the same active ingredient of Clobetasol. Even though it is possible to determine that Clovate includes the active substance of Clobetasol, there is nothing to say the remaining ingredients are entirely safe and acceptable to use. It is possible to confirm that Clobetasol is a satisfactory treatment option for skin conditions, but the overall effectiveness of the Clovate branded product from Dermocare Laboratories (Guj) Pvt Ltd is difficult to confirm. Limit the use of this medication to those occasions when prescribed by the doctor. When it comes to identifying the qualities of a particular type of drug, make sure to carefully research the specific brand and manufacturer.

Pricing and Dosages

Apply the cream as advised by your doctor. A typical dosage is applying Clovate twice daily (morning and evening) to the affected areas of the body. The pricing of this medication is in the region of Rs28.00 for a single 10 mg tube.

How to Buy Clovate Online

The Clovate medication is easily sourced using the web-based pharmacies that offer attractive deals and free shipping.

How to Use Clovate

Clovate is a topical ointment or cream and is applied externally to the affected skin areas. Make sure to wash the hands before and after using this treatment. Apply in a thin layer and gently rub until it is absorbed into the skin. The use of Clovate should be reduced if the skin complaint starts to improve.

Clovate Side Effects

Common side effects related to this topical treatment include gastralgia, skin rash, sedation, dry mouth, constipation, nausea, fatigue, and headache. Call the doctor for the more severe or persistent effects.

Conclusion

Clovate (Clobetasol) could well be a highly reliable and effective option for those wishing to treat the more serious skin complaints. Patients should be more cautious when there is a past history of allergies, recent vaccinations, scrapes, skin infection, or during pregnancy. Overall, the use of Clovate can only be given the desired mark of approval if relevant reviews from real users were available to read. Therefore, with no online reviews to refer to, we would only be able to rate Clovate with a mark of 1 out of 5 (5 is highest).

RxStars Review - 1 out of 5 stars by Sam W. Johnson

Acheter Alentol (Sarafem) Pas Cher Sans Ordonnance, Alentol

Acheter Alentol (Sarafem) Sans Ordonnance

ALENTOL (SARAFEM) INDICATIONS

Alentol est utilise pour traiter le trouble dysphorique premenstruel (PMDD), une forme grave de syndrome. Alentol premenstruel est un inhibiteur selectif du recaptage de la serotonine (ISRS). Il agit en retablissant l'equilibre de la serotonine, une substance naturelle dans le cerveau, ce qui contribue a ameliorer l'humeur.

ALENTOL (SARAFEM) INSTRUCTIONS

Utilisez Alentol comme dirige par votre medecin.

Prenez Alentol par voie orale avec ou sans nourriture. Prenant Alentol a la meme heure chaque jour vous aidera a vous rappeler de le prendre. Continuer a prendre Alentol, meme si vous vous sentez bien. Ne manquez pas de doses. Ne vous arretez pas brusquement de prendre Alentol sans verifier avec votre medecin. Les effets secondaires peuvent se produire. Ils peuvent inclure des changements mentaux ou d'humeur, des engourdissements ou des picotements de la peau, des etourdissements, de la confusion, des maux de tete, troubles du sommeil, ou une fatigue inhabituelle. Vous serez surveille de pres lorsque vous avez termine et commencez Alentol Chaque fois qu'un changement de dose est fait. Si vous manquez une dose de Alentol, prenez-la des que possible. S'il est presque temps pour votre prochaine dose, sautez la dose oubliee et revenir a votre programme de dosage regulier. Ne prenez pas 2 doses a la fois.

Posez toutes les questions que vous pourriez avoir sur la facon d'utiliser Alentol votre fournisseur de soins de sante.

ALENTOL (SARAFEM) STOCKAGE

Alentol de magasin a la temperature ambiante, entre 59 et 86 degres F (15 et 30 degres C). Conserver a l'abri de la chaleur, l'humidite et la lumiere. Ne pas stocker dans la salle de bain. Gardez Alentol hors de la portee des enfants et loin des animaux.

ALENTOL (SARAFEM) PLUS D'INFO:

Ingredient actif: chlorhydrate fluoxetine.

Ne pas utiliser Alentol si:

vous etes allergique a un ingredient de Alentol vous prenez ou avez pris un inhibiteur de la monoamine oxydase (IMAO) (par exemple, phenelzine), selegiline, ou le millepertuis Dans les 14 derniers jours vous prenez un derive de la fenfluramine (par exemple, la dexfenfluramine), un antagoniste H1 (par exemple, de l'astemizole, la terfenadine), nefazodone, pimozide, un inhibiteur de la recapture de la serotonine et de la noradrenaline (IRSN) (par exemple, la venlafaxine), un autre ISRS (par exemple, la paroxetine), sibutramine, thioridazine, ou le tryptophane.

Contactez votre medecin ou professionnel de la sante immediatement si l'un de ceux-ci s'appliquent a vous.

Certaines conditions medicales peuvent interagir avec Alentol. Dites a votre medecin ou votre pharmacien si vous avez des conditions medicales, surtout si une des conditions suivantes s'appliquent a vous:

si vous etes enceinte, prevoyez le devenir enceintes, ou l'allaitement au sein si vous prenez n'importe quelle prescription ou sans ordonnance, preparation a base de plantes ou de supplements alimentaires si vous avez des allergies aux medicaments, d'aliments ou d'autres substances si vous ou un membre de la famille a des antecedents de trouble bipolaire (maniaco-depression), d'autres problemes mentaux ou d'humeur, les pensees suicidaires ou de tentatives ou de l'alcool ou de toxicomanie si vous avez des antecedents de convulsions, problemes cardiaques, problemes de foie, des problemes renaux severes, l'estomac ou l'intestin saignement, le diabete ou des problemes de metabolisme si vous etes deshydrate, ont des niveaux de sodium dans le sang, ou boire de l'alcool si vous aurez la therapie par electrochocs (ECT).

Certains medicaments peuvent interagir avec Alentol. Dites a votre fournisseur de soins de sante si vous prenez d'autres medicaments, en particulier un des elements suivants:

Anorexigenes (par exemple, la phentermine), les derives de la fenfluramine (par exemple, dexfenfluramine), linezolide, IMAO (par exemple, phenelzine), le metoclopramide, la nefazodone, la selegiline, les agonistes de la serotonine des recepteurs 5-HT1 (par exemple, le sumatriptan), la sibutramine, IRSN (par exemple, la venlafaxine). l'herbe, la trazodone, ou le tryptophane de Saint-Jean en raison des effets secondaires graves. tels que dans cette reaction peuvent inclure fievre, rigidite musculaire, des changements de la pression arterielle, les changements mentaux, la confusion, irritabilite, agitation, delire, ou coma, peuvent se produire Anticoagulants (ex: warfarine), l'aspirine, ou des medicaments anti-inflammatoires non steroidiens (AINS) (ibuprofene, etc) Parce que le risque de saignement, y compris saignement de l'estomac, peut etre augmente a Les diuretiques (par exemple, le furosemide, hydrochlorothiazide), car le risque de niveaux de sodium dans le sang peut etre augmentee a Tramadol parce que le risque de convulsions peut etre augmentee a Cyclobenzaprine ou H1 antagonistes (par exemple, de l'astemizole, terfenadine) Parce que les problemes cardiaques graves, y compris les battements de c?ur irreguliers, peuvent se produire Inhibiteurs de la protease du VIH (par exemple, le ritonavir) car ils peuvent augmenter le risque d'effets secondaires de Alentol Cyproheptadine Parce qu'il peut diminuer l'efficacite de Alentol Aripiprazole, les benzodiazepines (par exemple, alprazolam), les beta-bloquants (par exemple, le propranolol), la carbamazepine, la clozapine, le dextromethorphane, la digoxine, flecainide, l'haloperidol, les hydantoines (par exemple, la phenytoine), le lithium, les inhibiteurs de la recapture de la noradrenaline (par exemple, l'atomoxetine), les phenothiazines ( par exemple, la chlorpromazine, thioridazine), le pimozide, la propafenone, la risperidone, antidepresseurs tricycliques (par exemple, amitriptyline), ou la vinblastine, car le risque de leurs effets secondaires peut etre augmente par A Alentol.

Cela peut ne pas etre une liste complete de toutes les interactions qui peuvent se produire. Demandez a votre fournisseur de soins de sante si Alentol peut interagir avec d'autres medicaments que vous prenez. Verifiez avec votre fournisseur de soins de sante avant de demarrer, d'arreter ou modifier la dose de tout medicament. Informations de securite importantes:

Alentol peut causer de la somnolence ou des etourdissements. Ces effets mai etre pire si vous le prenez avec de l'alcool ou certains medicaments. Prenez Alentol avec prudence. Ne pas conduire ou d'effectuer d'autres taches dangereuses possibles jusqu'a ce que vous savez comment vous reagissez. Verifiez aupres de votre medecin avant de consommer de l'alcool ou utilisez des medicaments qui peuvent causer de la somnolence (par exemple, somniferes, relaxants musculaires) pendant que vous prenez Alentol, il peut ajouter a leurs effets font. Demandez a votre pharmacien si vous avez des questions sur les medicaments qui peuvent causer de la somnolence. Plusieurs semaines peuvent s'ecouler avant que votre ameliorer les symptomes. Ne prenez pas mures que la dose recommandee, modifiez votre dose, ou prendre Alentol pour plus longtemps que prevu sans avoir consulte votre medecin. Les enfants et les adolescents qui prennent Alentol peut etre augmentee a un risque de pensees suicidaires ou des actions. Aussi les adultes peuvent etre affectes. Le risque peut etre plus eleve chez les patients qui ont eu des pensees suicidaires ou des actions dans le passe. En outre, le risque peut etre plus eleve chez les patients qui ont eu bipolaire (maniaco-depressif) maladie, ou si leurs membres de la famille ont eu il. Regardez les patients qui prennent Alentol pres. Contacter le medecin immediatement si nouveau, aggrave, ou soudaine des symptomes tels que: l'humeur depressive, comportement anxieux, agite ou irritable, les attaques de panique, ou tout changement inhabituel, d'humeur ou de comportement se produisent. Contactez immediatement le medecin si des signes de pensees suicidaires ou des actions se produisent. Les patients diabetiques - Alentol peuvent affecter votre taux de sucre dans le sang. Verifiez des niveaux de sucre dans le sang. Demandez a votre medecin avant de modifier la dose de votre medicament de diabete. Le syndrome serotoninergique est un syndrome eventuellement mortelle qui peut etre causee par Alentol. Le risque peut etre plus eleve si vous prenez Alentol avec les Nations Unies certains autres medicaments (par exemple, les IMAO, ISRS, «triptans»). Les symptomes peuvent inclure l'agitation, coma, confusion, transpiration excessive, rythme cardiaque rapide ou irregulier, la fievre, des hallucinations, des nausees, des vomissements ou de la diarrhee, des tremblements. Contactez votre medecin immediatement si vous avez un de ces symptomes. Syndrome malin des neuroleptiques (SMN) est un syndrome eventuellement mortelle qui peut etre causee par Alentol. Les symptomes peuvent comprendre de la fievre, une raideur des muscles, de la confusion, troubles de la pensee, un rythme cardiaque rapide ou irregulier, et la transpiration. Contactez votre medecin immediatement si vous avez un de ces symptomes. Si votre medecin vous dit de cesser de prendre Alentol, vous devrez attendre plusieurs semaines avant de commencer a prendre des nations unies certains autres medicaments (par exemple, les IMAO, nefazodone, thioridazine). Demandez a votre medecin quand vous avez fini devriez commencer a prendre vos medicaments nouveaux apres avoir cesse de prendre Alentol. Alentol peut rarement causer une erection prolongee et douloureuse. Cela pourrait se produire meme lorsque vous avez fini pas de sexe. Si ce n'est pas traitee immediatement, il pourrait conduire a des problemes sexuels permanents tels que l'impuissance. Contactez votre medecin immediatement si cela se produit. Alentol contient quelques-uns des memes ingredients que le Prozac, un medicament utilise pour traiter la depression et d'autres problemes de sante mentale, et Symbyax, un medicament utilise pour traiter la depression chez les patients atteints de trouble bipolaire. Ne prenez pas Alentol Aussi, si vous prenez du Prozac ou Symbyax. Discuter des questions ou des preoccupations a votre medecin. Utilisez Alentol avec prudence chez les personnes agees, ils ne peuvent pas etre plus sensibles a ses effets, les niveaux sanguins de sodium particulierement bas. La prudence est recommandee en cas d'utilisation Alentol enfants, ils ne peuvent etre plus sensibles aux effets, particulierement accrue au risque de pensees suicidaires ou des actions. Alentol doit etre utilise avec extreme prudence chez les enfants, la securite et l'efficacite chez les enfants n'ont pas ete confirmees. Alentol peut provoquer des changements de poids. Les enfants et les adolescents peuvent avoir besoin de poids reguliere et des controles de croissance pendant qu'ils prennent Alentol. Grossesse et allaitement: Alentol peut causer des dommages au foetus s'il est utilise pendant les 3 derniers mois de grossesse. Si vous tombez enceinte, contactez votre medecin. Vous aurez besoin de discuter des avantages et des risques de Alentol pendant que vous etes enceinte. Alentol se trouve dans le lait maternel. Ne pas allaiter pendant que vous prenez Alentol.

Tous les medicaments peuvent provoquer des effets secondaires, mais beaucoup de gens n'ont pas, ou mineur, les effets secondaires.

Verifiez aupres de votre medecin si l'un de ces effets indesirables les plus courants persistent ou deviennent incommodants:

Anxiete, diminution du desir sexuel ou de la capacite, diarrhee, etourdissements, somnolence, secheresse de la bouche, symptomes pseudo-grippaux (fievre, frissons, douleurs musculaires), a augmente a la transpiration, perte d'appetit, nausees, nervosite, nez qui coule, maux de gorge, de l'estomac estomac, troubles du sommeil, de la faiblesse.

Consulter un medecin immediatement si l'un d'effets secondaires graves ci se produisent:

Les reactions allergiques graves (eruption cutanee, urticaire, demangeaisons, difficulte a respirer, sensation d'oppression dans la poitrine, enflure de la bouche, du visage, des levres ou de la langue, enrouement inhabituel), comportement bizarre, selles noires ou sanglantes, douleur thoracique, confusion, diminution Au concentration; diminue a la coordination, des reflexes exageres, transpiration excessive, evanouissements, rythme cardiaque rapide ou irregulier, la fievre, des frissons ou maux de gorge, hallucinations, augmente a la faim, la soif, ou la miction, des douleurs ou des douleurs articulaires ou du poignet, la perte de memoire, agitation ou d'aggravation, la panique attaques, l'agressivite, l'impulsivite, l'irritabilite, l'hostilite, sentiment exagere de bien-etre, l'agitation ou incapacite a rester assis, sonnerie persistante ou severe dans les oreilles, persistante, une erection douloureuse, la peau rouge, enflee, boursouflee, ou desquamation, des convulsions; l'anxiete graves ou persistants, des troubles du sommeil, ou de la faiblesse, des nausees severes ou persistantes, des vomissements, la diarrhee ou des maux de tete, perte de poids importante, douleurs a l'estomac, des pensees suicidaires ou de tentatives, tremblements, des ecchymoses ou des saignements inhabituels, enrouement inhabituel, inhabituelle ou mentale grave ou changements d'humeur, enflure inhabituelle, faiblesse inhabituelle, des changements de vision, aggravation de la depression.

Ce n'est pas une liste complete de tous les effets secondaires qui peuvent survenir. Si vous avez des questions sur les effets secondaires, communiquez avec votre fournisseur de soins de sante.

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Paroxetine Side Effects In Detail, Paxetin

Paroxetine Side Effects

In Summary

Commonly reported side effects of paroxetine include: nausea, insomnia, dizziness, weakness, erectile dysfunction, male genital disease, drowsiness, ejaculatory disorder, diarrhea, constipation, headache, diaphoresis, decreased libido, delayed ejaculation, and xerostomia. Other side effects include: infection, lack of concentration, vasodilatation, female genital tract disease, tremor, orgasm disturbance, blurred vision, visual disturbance, impotence, anxiety, paresthesia, yawning, abnormal dreams, and decreased appetite. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to paroxetine: oral capsule, oral suspension, oral tablet, oral tablet extended release

As well as its needed effects, paroxetine may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking paroxetine, check with your doctor immediately:

Less common:

Agitation

chest congestion

chest pain

chills

cold sweats

confusion

difficulty with breathing

dizziness, faintness, or lightheadedness when getting up from a lying or sitting position

fast, pounding, or irregular heartbeat or pulse

muscle pain or weakness

skin rash

Rare

Absence of or decrease in body movements

bigger, dilated, or enlarged pupils (black part of the eye)

convulsions (seizures)

difficulty with speaking

dry mouth

fever

inability to move the eyes

incomplete, sudden, or unusual body or facial movements

increased sensitivity of the eyes to light

poor coordination

red or purple patches on the skin

restlessness

shivering

sweating

talking, feeling, and acting with excitement and activity you cannot control

trembling or shaking, or twitching

Incidence not known:

Back, leg, or stomach pains

blindness

blistering, peeling, or loosening of the skin

blue-yellow color blindness

blurred vision

constipation

cough or hoarseness

dark urine

decreased frequency or amount of urine

decreased vision

difficulty with swallowing

electric shock sensations

eye pain

fainting

general body swelling

headache

high fever

hives or itching skin

inability to move the arms and legs

inability to sit still

increased thirst

incremental or ratchet-like movement of the muscle

joint pain

light-colored stools

lockjaw

loss of appetite

loss of bladder control

lower back or side pain

muscle spasm, especially of the neck and back

muscle tension or tightness

painful or difficult urination

painful or prolonged erection of the penis

pale skin

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

raised red swellings on the skin, the buttocks, legs, or ankles

red, irritated eyes

sensitivity to the sun

skin redness or soreness

slow heart rate

sores, ulcers, or white spots on the lips or in the mouth

spasms of the throat

stiff muscles

stomach pain

sudden numbness and weakness in the arms and legs

swelling of the breasts

swelling of the face, fingers, or lower legs

swollen or painful glands

tightness in the chest

unexpected or excess milk flow from the breasts

unusual bleeding or bruising

unusual tiredness or weakness

vomiting

weight gain

yellowing of the eyes or skin

Minor Side Effects

Some paroxetine side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:

Acid or sour stomach

belching

decreased appetite

decreased sexual ability or desire

heartburn

pain or tenderness around the eyes and cheekbones

passing gas

problems with urinating

runny or stuffy nose

sexual problems, especially ejaculatory disturbances

sleepiness or unusual drowsiness

stomach discomfort or upset

trouble sleeping

Less common:

Abnormal dreams

change in sense of taste

congestion

discouragement, feeling sad, or empty

drugged feeling

fast or irregular breathing

feeling of unreality

headache, severe and throbbing

increased appetite

itching of the vagina or genital area

itching, pain, redness, or swelling of the eye or eyelid

lack of emotion

loss of interest or pleasure

lump in the throat

menstrual changes

pain during sexual intercourse

problems with memory

sense of detachment from self or body

sneezing

thick, white vaginal discharge with no odor or with a mild odor

tightness in the throat

tingling, burning, or prickling sensations

trouble concentrating

voice changes

watering of the eyes

weight loss

yawn

For Healthcare Professionals

Applies to paroxetine: oral capsule, oral suspension, oral tablet, oral tablet extended release

General

Side effects are generally reported as mild. The most common side effects associated with treatment discontinuation in clinical trials included somnolence, insomnia, agitation, tremor, anxiety, dizziness, headache, constipation, nausea, diarrhea, dry mouth, vomiting, flatulence, asthenia, abnormal ejaculation, sweating, impotence, and decreased libido.

The most common dose-dependent side effects associated with treatment discontinuation in clinical trials for the treatment of premenstrual dysphoric disorder with controlled-release paroxetine 25 mg compared with 12.5 mg included nausea, somnolence, impaired concentration, dry mouth, dizziness, decreased appetite, sweating, tremor, and yawn.

The most common side effects associated with treatment discontinuation in the treatment of vasomotor symptoms in clinical trials included abdominal pain, attention disturbances, headache, and suicidal ideation.

In a placebo-controlled study in elderly patients with major depressive disorder, the most common side effects associated with treatment discontinuation of controlled-release paroxetine included nausea, headache, depression, and abnormal LFTs.

There may be adaptation to some side effects (such as nausea and dizziness) but not to others (such as dry mouth, somnolence, and asthenia) with continued therapy. Paroxetine is less likely than tricyclic antidepressants to be associated with dry mouth, constipation, and somnolence. [Ref ]

Psychiatric

Very common (10% or more): Insomnia Common (1% to 10%): Abnormal dreams, agitation, anxiety, depersonalization, depression, drugged feeling, emotional lability, lack of emotion, nervousness Uncommon (0.1% to 1%): Abnormal thinking, alcohol abuse, bruxism, euphoria, hallucinations, hostility, lack of emotion, manic reaction, neurosis, paranoid reaction Rare (less than 0.1%): Abnormal electroencephalogram, antisocial reaction, bulimia, delirium, delusions, drug dependence, hysteria, irritability, manic-depressive reaction, panic attacks, psychosis, psychotic depression, stupor, withdrawal syndrome Frequency not reported: Suicidal ideation and behavior Postmarketing reports: Confusional state, disorientation, homicidal ideation, restlessness [Ref ]

Antidepressants may have a role in inducing worsening of depression and the emergence of suicidality in certain patients during the early phases of treatment. An increased risk of suicidal thinking and behavior in children, adolescents, and young adults (aged 18 to 24 years) with major depressive disorder (MDD) and other psychiatric disorders has been reported with short-term use of antidepressant drugs.

Adult and pediatric patients receiving antidepressants for MDD, as well as for psychiatric and nonpsychiatric indications, have reported symptoms that may be precursors to emerging suicidality, including anxiety, agitation, panic attacks, insomnia, irritability, hostility, aggressiveness, impulsivity, akathisia, hypomania, and mania. Causality has not been established.

Pooled results from clinical trials report hallucinations in 22 of 9089 patients who received paroxetine and 4 of 3187 patients who received placebo. [Ref ]

Nervous system

Extrapyramidal symptoms such as akathisia, bradykinesia, cogwheel rigidity, dystonia, hypertonia, and oculogyric crisis have been associated with concomitant pimozide therapy.

Potentially life-threatening serotonin syndrome has been reported with SSRIs and SNRIs as monotherapy, but particularly with concomitant use of other serotonergic drugs and drugs that impair the metabolism of serotonin. Signs and symptoms associated with serotonin syndrome or neuroleptic malignant syndrome included agitation, confusion, diaphoresis, diarrhea, fever, hypertension, rigidity, and tachycardia, and were in some cases associated with concomitant use of serotonergic drugs. [Ref ]

Very common (10% or more): Dizziness, headache, somnolence, tremor Common (1% to 10%): Amnesia, anxiety, CNS stimulation, confusion, hypertonia, impaired concentration, migraine, myoclonus, paresthesia, taste perversion Uncommon (0.1% to 1%): Ataxia, convulsion, dyskinesia, dystonia, hyperesthesia, hyperkinesia, hypokinesia, incoordination, neuralgia, neuropathy, nystagmus, paralysis, syncope Rare (less than 0.1%): Abnormal gait, adrenergic syndrome, akathisia, akinesia, anticholinergic syndrome, aphasia, cerebral ischemia, cerebrovascular accident, choreoathetosis, circumoral paresthesia, dysarthria, extrapyramidal syndrome, fasciculations, grand mal convulsions, hyperalgesia, meningitis, myelitis, peripheral neuritis, reflexes decreased, reflexes increased, taste loss, torticollis, trismus, vascular headache Postmarketing reports: Eclampsia, Guillain-Barre syndrome, neuroleptic malignant syndrome, restless legs syndrome, serotonin syndrome, status epilepticus [Ref ]

Metabolic

The results of one study appear to indicate that treatment with selective serotonin reuptake inhibitors (i. e. paroxetine, sertraline, citalopram) may cause an increase in serum total cholesterol, HDL cholesterol, and/or LDL cholesterol. However, additional studies are necessary to confirm these findings.

Numerous cases of hyponatremia have been reported following treatment with a selective serotonin reuptake inhibitor (SSRI). Risk factors for the development of SSRI - associated hyponatremia including advanced age, female gender, concomitant use of diuretics, low body weight, and lower baseline serum sodium levels have been identified. Hyponatremia tends to develop within the first few weeks of treatment (range 3 to 120 days) and typically resolves within 2 weeks (range 48 hours to 6 weeks) after therapy has been discontinued with some patients requiring treatment. The proposed mechanism for the development of hyponatremia involves the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) via release of antidiuretic hormone. [Ref ]

Common (1% to 10%): Decreased appetite, increased appetite, increases in cholesterol levels, weight gain, weight loss Uncommon (0.1% to 1%): Hypoglycemia, hypokalemia, thirst Rare (less than 0.1%): Alkaline phosphatase increased, creatinine phosphokinase increased, dehydration, diabetes mellitus, gamma globulins increased, gout, hypercalcemia, hypercholesteremia, hyperglycemia, hyperkalemia, hyperphosphatemia, hypocalcemia, hyponatremia, ketosis, lactic dehydrogenase increased, non-protein nitrogen increased, obesity Postmarketing reports: Porphyria [Ref ]

Cardiovascular

Common (1% to 10%): Chest pain, edema, palpitation, peripheral edema, tachycardia, vasodilation (usually flushing) Uncommon (0.1% to 1%): Abnormal electrocardiogram, angina pectoris, bradycardia, conduction abnormalities, hematoma, hypertension, hypotension, palpitation, postural hypotension, sinus tachycardia, supraventricular tachycardia Rare (less than 0.1%): Arrhythmia, arrhythmia nodal, atrial arrhythmia, atrial fibrillation, bundle branch block, cellulitis, congestive heart failure, extrasystoles, heart block, low cardiac output, myocardial infarct, myocardial ischemia, pallor, phlebitis, substernal chest pain, supraventricular extrasystoles, thrombophlebitis, thrombosis, varicose vein, ventricular extrasystoles Postmarketing reports: Atrial fibrillation, pulmonary edema, ventricular fibrillation, ventricular tachycardia (including torsades de pointes) [Ref ]

Other

Fatigue, malaise, and lethargy were very commonly reported in Phase 2 and 3 clinical trials with paroxetine for treatment of vasomotor symptoms in postmenopausal women. [Ref ]

Very common (10% or more): Asthenia Common (1% to 10%): Chills, pain, tinnitus, trauma, vertigo Uncommon (0.1% to 1%): Ear pain, fever, malaise, otitis media, overdose Rare (less than 0.1%): Abscess, deafness, hypothermia, otitis externa, sepsis, ulcer, abnormal laboratory value, cyst, hernia, intentional overdose Postmarketing reports: Death [Ref ]

Genitourinary

Very common (10% or more): Decreased libido, ejaculation disturbance, other male genital disorders (primarily ejaculatory delay) Common (1% to 10%): Female genital disorders (primarily anorgasmia and difficulty reaching climax/orgasm), dysmenorrhea, impotence, menorrhagia, menstrual disorder, urinary disorder (primarily difficulty with micturition and urinary hesitancy), urinary frequency, urination impaired, urinary tract infection, vaginal moniliasis, vaginitis Uncommon (0.1% to 1%): Albuminuria, amenorrhea, breast pain, cystitis, dysuria, hematuria, increased libido, nocturia, ovarian cyst, polyuria, pyuria, pregnancy and puerperal disorders, testes pain, urinary incontinence, urinary retention, urinary urgency, Rare (0.01% to 0.1%): Abortion, breast atrophy, breast enlargement, endometrial disorder, epididymitis, female lactation, fibrocystic breast, kidney calculus, kidney pain, leukorrhea, mastitis, metrorrhagia, nephritis, oliguria, pelvic pain, salpingitis, urethritis, urinary abnormality, urinary casts, uterine spasm, urolith, vaginal hemorrhage Very rare (less than 0.01%): Priapism Postmarketing reports: Premature births in pregnant women, symptoms suggestive of galactorrhea [Ref ]

There are several reports of priapism associated with paroxetine use. In cases in which outcome was reported, all patients fully recovered.

In placebo-controlled clinical trials, ejaculatory disturbance in men was reported in 13% to 28% of men taking paroxetine, compared to 0% to 2% in the placebo group. Decreased libido was reported in 6% to 15% in men treated with paroxetine, compared to 0% to 5% in the placebo group, and in 0% to 9% in women treated with paroxetine, compared with 0% to 2% in placebo patients. The estimates of the incidence of untoward sexual experience and performance may underestimate their actual incidence, partly because patients and physicians may be reluctant to discuss this issue. [Ref ]

Dermatologic

Seven cases of alopecia have been reported. In all cases, hair loss was eventually reversible.

A case of cutaneous leukocytoclastic vasculitis has been reported following treatment with paroxetine. The patient originally developed the lesions after treatment with escitalopram. The lesions disappeared one week following discontinuation of escitalopram and reappeared upon rechallenge. When the patient was switched to paroxetine a similar reaction occurred. [Ref ]

Very common (10% or more): Sweating Common (1% to 10%): Eczema, hypertension, photosensitivity, pruritus, rash, sweat gland disorder Uncommon (0.1% to 1%): Acne, alopecia, contact dermatitis, dry skin, ecchymosis, furunculosis, purpura, urticaria Rare (0.01% to 0.1%): Angioedema, erythema multiforme, erythema nodosum, exfoliative dermatitis, fungal dermatitis, hirsutism, maculopapular rash, pustular rash, seborrhea, skin discoloration, skin hypertrophy, skin ulcer, sweating decreased, vesiculobullous rash Very rare (less than 0.01%): Severe cutaneous reactions such as Stevens Johnson syndrome and toxic epidermal necrolysis) Postmarketing reports: Vasculitic syndromes (such as Henoch-Schonlein purpura) [Ref ]

Endocrine

Rare (less than 0.1%): Goiter, hyperthyroidism, hypothyroidism, thyroiditis Postmarketing reports: Syndrome of inappropriate antidiuretic hormone secretion, symptoms suggestive of prolactinemia [Ref ]

Gastrointestinal

A study of 26,005 antidepressant users has reported 3.6 times more upper GI bleeding episodes with the use of SSRIs relative to the population who did not receive antidepressant medications. Upper gastrointestinal tract bleeding was observed up to 3.2 times more frequently in patients receiving paroxetine. [Ref ]

Very common (10% or more): Constipation, diarrhea, dry mouth, nausea Common (1% to 10%): Abdominal pain, dyspepsia, flatulence, gastrointestinal disorder, gingivitis, stomatitis, tooth disorder, vomiting Uncommon (0.1% to 1%): Buccal cavity disorders, colitis, dysphagia, eructation, gastritis, gastroenteritis, gastroesophageal reflux, gastrointestinal flu, gingivitis, glossitis, increased salivation, melena, pancreatitis, rectal hemorrhage, toothache, ulcerative stomatitis Rare (less than 0.1%): Aphthous stomatitis, bloody diarrhea, cardiospasm, cholelithiasis, duodenitis, enteritis, esophagitis, fecal impaction, fecal incontinence, gum hemorrhage, gum hyperplasia, hematemesis, ileitis, ileus, intestinal obstruction, mouth ulceration, peptic ulcer, peritonitis, salivary gland enlargement, sialadenitis, stomach ulcer, tooth caries, tongue discoloration, tongue edema, tooth malformation Postmarketing reports: Acute pancreatitis, pancreatitis hemorrhagic [Ref ]

Hematologic

Uncommon (0.1% to 1%): Anemia, eosinophilia, hypochromic anemia, leukocytosis, leukopenia, lymphadenopathy, WBC abnormality Rare (less than 0.1%): Abnormal erythrocytes, abnormal lymphocytes, anisocytosis, basophilia, bleeding time increased, iron deficiency anemia, lymphedema, lymphocytosis, lymphopenia, microcytic anemia, monocytosis, normocytic anemia, thrombocytopenia, thrombocythemia, Postmarketing reports: Events related to impaired hematopoiesis (including aplastic anemia, pancytopenia, bone marrow aplasia, agranulocytosis), hemolytic anemia, idiopathic thrombocytopenic purpura [Ref ]

Hepatic

Uncommon (0.1% to 1%): Abnormal liver function tests, SGOT increased, SGPT increased Rare (less than 0.1%): Bilirubinemia, hepatitis, hepatosplenomegaly, jaundice Postmarketing reports: Drug-induced liver injury, elevated liver function tests, hepatic failure [Ref ]

In placebo-controlled clinical trials patients receiving paroxetine experienced abnormal values on liver function tests at a rate equal to or less than that reported in patients receiving placebo. However, there have been postmarketing reports of patients developing elevated serum transaminases resulting in severe liver dysfunction, as well as, a few cases of elevated liver function tests resulting in death secondary to liver necrosis. [Ref ]

Hypersensitivity

Uncommon (0.1% to 1%): Allergic reaction, face edema Rare (less than 0.1%): Anaphylactoid reaction Postmarketing reports: Anaphylaxis [Ref ]

Immunologic

Common (1% to 10%): Infection Uncommon (0.1% to 1%): Flu syndrome, herpes simplex Rare (less than 0.1%): Herpes zoster, moniliasis [Ref ]

Musculoskeletal

Epidemiological studies, primarily in patients aged 50 years or older, have shown an increased risk of bone fractures in patients receiving SSRIs or TCAs. [Ref ]

Common (1% to 10%): Arthralgia, back pain, migraine, myalgia, myasthenia, myopathy Uncommon (0.1% to 1%): Arthritis, arthrosis, bursitis, myositis, neck pain, tendonitis, traumatic fracture Rare (less than 0.1%): Cartilage disorder, generalized spasm, myositis, neck rigidity, osteoporosis, tenosynovitis, tetany [Ref ]

Ocular

Common (1% to 10%): Abnormality of accommodation, abnormal vision, blurred vision Uncommon (0.1% to 1%): Conjunctivitis, eye pain, keratoconjunctivitis, mydriasis, photophobia, retinal hemorrhage Rare (less than 0.1%): Anisocoria, blepharitis, cataract, conjunctival edema, corneal lesion, corneal ulcer, diplopia, exophthalmos, eye hemorrhage, glaucoma, hyperacusis, night blindness, ptosis, visual field defect Frequency not reported: Angle-closure glaucoma, eye pain Postmarketing reports: Acute glaucoma, optic neuritis [Ref ]

Renal

Rare (less than 0.1%): Abnormal kidney function, BUN increased Postmarketing reports: Acute renal failure [Ref ]

Respiratory

Common (1% to 10%): Bronchitis, cough increased, oropharynx disorder, pharyngitis, respiratory disorder, rhinitis, sinusitis, yawn Uncommon (0.1% to 1%): Asthma, dyspnea, epistaxis, hyperventilation, laryngitis, pneumonia, respiratory flu Rare (less than 0.1%): Dysphonia, emphysema, hemoptysis, hiccups, lung fibrosis, parosmia, pulmonary edema, pulmonary embolus, sputum increased, stridor, throat tightness, voice alteration Postmarketing reports: Allergic alveolitis, laryngismus, pulmonary hypertension [Ref ]

References

1. "Product Information. Pexeva (PARoxetine)." Synthon Pharmaceuticals Ltd, Chapel Hill, NC.

2. "Product Information. Paxil CR (paroxetine)." SmithKline Beecham, Philadelphia, PA.

3. Cerner Multum, Inc. "Australian Product Information." O 0

4. "Product Information. Brisdelle (PARoxetine)." Noven Pharmaceuticals, Inc. New York, NY.

5. "Product Information. Paxil (paroxetine)." GlaxoSmithKline, Research Triangle Park, NC.

6. Boyer WF, Blumhardt CL "The safety profile of paroxetine." J Clin Psychiatry 53 Suppl (1992): 61-6

7. Staner L, Kerkhofs M, Detroux D, Leyman S, Linkowski P, Mendlewicz J "Acute, subchronic and withdrawal sleep EEG changes during treatment with paroxetine and amitriptyline: a double-blind randomized trial in major depression." Sleep 18 (1995): 470-7

8. Adler LA, Angrist BM "Paroxetine and akathisia." Biol Psychiatry 37 (1995): 336-7

9. Paruchuri P, Godkar D, Anandacoomarswamy D, Sheth K, Niranjan S "Rare case of serotonin syndrome with therapeutic doses of paroxetine." Am J Ther 13 (2006): 550-552

10. Patkar AA, Masand PS, Krulewicz S, et al. "A randomized, controlled, trial of controlled release paroxetine in fibromyalgia." Am J Med 120 (2007): 448-54

11. Fava GA, Grandi S "Withdrawal syndromes after paroxetine and sertraline discontinuation." J Clin Psychopharmacol 15 (1995): 374-5

12. Bloch M, Stager SV, Braun AR, Rubinow DR "Severe psychiatric symptoms associated with paroxetine withdrawal." Lancet 346 (1995): 57

13. Phillips SD "Possible paroxetine withdrawal syndrome." Am J Psychiatry 152 (1995): 645-6

14. Jacob S, Spinler SA "Hyponatremia associated with selective serotonin-reuptake inhibitors in older adults." Ann Pharmacother 40 (2006): 1618-22

15. Herran A, Ramirez ML, Carrera M, et al. "Panic disorder, treatment with selective serotonin reuptake inhibitors, and cholesterol levels." J Clin Psychopharmacol 26 (2006): 538-40

16. Rothschild AJ "Sexual side effects of antidepressants." J Clin Psychiatry 61 (2000): 28-36

17. Ahmad S "Paroxetine-induced priapism." Arch Intern Med 155 (1995): 645

18. Flores-Suarez LF, Vega-Memije ME, Chanussot-Deprez C "Cutaneous vasculitis during selective serotonin reuptake inhibitor therapy." Am J Med 119 (2006): e1-3

19. Ahmed R, Eagleton C "Toxic epidermal necrolysis after paroxetine treatment." N Z Med J 121 (2008): 86-9

20. Margolese HC, Chouinard G, Beauclair L, Rubino M "Cutaneous vasculitis induced by paroxetine." Am J Psychiat 158 (2001): 497

21. Gautam M "Alopecia due to psychotropic medications." Ann Pharmacother 33 (1999): 631-7

22. Ayonrinde OT, Reutens SG, Sanfilippo FM "Paroxetine-induced SIADH." Med J Aust 163 (1995): 390

23. Madhusoodanan S, Brenner R, Brafman I, Bogunovic O "Hyponatremia associated with paroxetine use." South Med J 92 (1999): 843

24. Chua TP, Vong SK "Hyponatraemia associated with paroxetine." BMJ 306 (1993): 143

25. Odeh M, Seligmann H, Oliven A "Severe life-threatening hyponatremia during paroxetine therapy." J Clin Pharmacol 39 (1999): 1290-1

26. Goddard C, Paton C "Hyponatraemia associated with paroxetine." BMJ 305 (1992): 1332

27. van Campen JP, Voets AJ "SIADH caused by paroxetine." Ann Pharmacother 30 (1996): 1499

28. Spigset O, hedenmalm K "Hyponatremia in relation to treatment with antidepressants: a survey of reports in the World Health Organization data base for spontaneous reporting of adverse drug reactions." Pharmacotherapy 17 (1997): 348-52

29. Dalton SO, Johansen C, Mellemkjaer L, Norgard B, Sorensen HT, Olsen JH "Use of selective serotonin reuptake inhibitors and risk of upper gastrointestinal tract bleeding: a population-based cohort study." Arch Intern Med 163 (2003): 59-64

30. Ottervanger JP, Stricker BH, Huls J, Weeda JN "Bleeding attributed to the intake of paroxetine." Am J Psychiatry 151 (1994): 781-2

31. Odeh M, Misselevech I, Boss JH, Oliven A "Severe hepatotoxicity with jaundice associated with paroxetine." Am J Gastroenterol 96 (2001): 2494-6

32. Liu B, Anderson G, Mittmann N, To Teresa, Axcell T, Shear N "Use of selective serotonin-reuptake inhibitors or tricyclic antidepressants and risk of hip fractures in elderly people." Lancet 351 (1998): 1303-7

It is possible that some side effects of paroxetine may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

More about paroxetine

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Related treatment guides

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill. knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs. com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

Drug Status

Disulfiram - Fda Prescribing Information, Side Effects And Uses, Disulfiramo

Disulfiram

STRUCTURAL FORMULA:

Disulfiram occurs as a white to off-white, odorless, and almost tasteless powder, soluble in water to the extent of about 20 mg in 100 mL, and in alcohol to the extent of about 3.8 g in 100 mL.

Each tablet for oral administration contains 250 mg or 500 mg Disulfiram, USP. Tablets also contain crospovidone, lactose monohydrate, magnesium stearate, microcrystalline cellulose, povidone and silicon dioxide.

CLINICAL PHARMACOLOGY:

Disulfiram produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol.

Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage. During alcohol metabolism following Disulfiram intake, the concentration of acetaldehyde occurring in the blood may be 5 to 10 times higher than that found during metabolism of the same amount of alcohol alone.

Accumulation of acetaldehyde in the blood produces a complex of highly unpleasant symptoms referred to hereinafter as the Disulfiram-alcohol reaction. This reaction, which is proportional to the dosage of both Disulfiram and alcohol, will persist as long as alcohol is being metabolized. Disulfiram does not appear to influence the rate of alcohol elimination from the body.

Disulfiram is absorbed slowly from the gastrointestinal tract and is eliminated slowly from the body. One (or even two) weeks after a patient has taken his last dose of Disulfiram, ingestion of alcohol may produce unpleasant symptoms.

Prolonged administration of Disulfiram does not produce tolerance; the longer a patient remains on therapy, the more exquisitely sensitive he becomes to alcohol.

INDICATIONS AND USAGE:

Disulfiram is an aid in the management of selected chronic alcohol patients who want to remain in a state of enforced sobriety so that supportive and psychotherapeutic treatment may be applied to best advantage.

Disulfiram is not a cure for alcoholism. When used alone, without proper motivation and supportive therapy, it is unlikely that it will have any substantive effect on the drinking pattern of the chronic alcoholic.

CONTRAINDICATIONS:

Patients who are receiving or have recently received metronidazole, paraldehyde, alcohol, or alcohol-containing preparations, e. g. cough syrups, tonics and the like, should not be given Disulfiram.

Disulfiram is contraindicated in the presence of severe myocardial disease or coronary occlusion, psychoses, and hypersensitivity to Disulfiram or to other thiuram derivatives used in pesticides and rubber vulcanization.

WARNINGS:

Disulfiram should never be administered to a patient when he is in a state of alcohol intoxication, or without his full knowledge. The physician should instruct relatives accordingly.

The patient must be fully informed of the Disulfiram-alcohol reaction. He must be strongly cautioned against surreptitious drinking while taking the drug, and he must be fully aware of the possible consequences. He should be warned to avoid alcohol in disguised forms, i. e. in sauces, vinegars, cough mixtures, and even in aftershave lotions and back rubs. He should also be warned that reactions may occur with alcohol up to 14 days after ingesting Disulfiram.

The Disulfiram-Alcohol Reaction:

Disulfiram plus alcohol, even small amounts, produce flushing, throbbing in head and neck, throbbing headache, respiratory difficulty, nausea, copious vomiting, sweating, thirst, chest pain, palpitation, dyspnea, hyperventilation, tachycardia, hypotension, syncope, marked uneasiness, weakness, vertigo, blurred vision, and confusion. In severe reactions there may be respiratory depression, cardiovascular collapse, arrhythmias, myocardial infarction, acute congestive heart failure, unconsciousness, convulsions, and death.

The intensity of the reaction varies with each individual, but is generally proportional to the amounts of Disulfiram and alcohol ingested. Mild reactions may occur in the sensitive individual when the blood alcohol concentration is increased to as little as 5 to 10 mg per 100 mL. Symptoms are fully developed at 50 mg per 100 mL, and unconsciousness usually results when the blood alcohol level reaches 125 to 150 mg.

The duration of the reaction varies from 30 to 60 minutes, to several hours in the more severe cases, or as long as there is alcohol in the blood.

Concomitant Conditions:

Because of the possibility of an accidental Disulfiram-alcohol reaction, Disulfiram should be used with extreme caution in patients with any of the following conditions: diabetes mellitus, hypothyroidism, epilepsy, cerebral damage, chronic and acute nephritis, hepatic cirrhosis or insufficiency.

PRECAUTIONS:

Patients with a history of rubber contact dermatitis should be evaluated for hypersensitivity to thiuram derivatives before receiving Disulfiram (see CONTRAINDICATIONS) .

It is suggested that every patient under treatment carry an Identification Card stating that he is receiving Disulfiram and describing the symptoms most likely to occur as a result of the Disulfiram-alcohol reaction. In addition, this card should indicate the physician or institution to be contacted in an emergency. (Cards may be obtained from Sigmapharm Laboratories, LLC. upon request.)

Alcoholism may accompany or be followed by dependence on narcotics or sedatives. Barbiturates and Disulfiram have been administered concurrently without untoward effects; the possibility of initiating a new abuse should be considered.

Hepatic toxicity including hepatic failure resulting in transplantation or death have been reported. Severe and sometimes fatal hepatitis associated with Disulfiram therapy may develop even after many months of therapy. Hepatic toxicity has occurred in patients with or without prior history of abnormal liver function. Patients should be advised to immediately notify their physician of any early symptoms of hepatitis, such as fatigue, weakness, malaise, anorexia, nausea, vomiting, jaundice, or dark urine.

Baseline and follow-up liver function tests (10-14 days) are suggested to detect any hepatic dysfunction that may result with Disulfiram therapy. In addition, a complete blood count and serum chemistries, including liver function tests, should be monitored.

Patients taking Disulfiram tablets should not be exposed to ethylene dibromide or its vapors. This precaution is based on preliminary results of animal research currently in progress that suggest a toxic interaction between inhaled ethylene dibromide and ingested Disulfiram resulting in a higher incidence of tumors and mortality in rats. A correlation between this finding and humans, however, has not been demonstrated.

Drug Interactions:

Disulfiram appears to decrease the rate at which certain drugs are metabolized and therefore may increase the blood levels and the possibility of clinical toxicity of drugs given concomitantly.

Disulfiram SHOULD BE USED WITH CAUTION IN THOSE PATIENTS RECEIVING PHENYTOIN AND ITS CONGENERS, SINCE THE CONCOMITANT ADMINISTRATION OF THESE TWO DRUGS CAN LEAD TO PHENYTOIN INTOXICATION. PRIOR TO ADMINISTERING Disulfiram TO A PATIENT ON PHENYTOIN THERAPY, A BASELINE PHENYTOIN SERUM LEVEL SHOULD BE OBTAINED. SUBSEQUENT TO INITIATION OF Disulfiram THERAPY, SERUM LEVELS OF PHENYTOIN SHOULD BE DETERMINED ON DIFFERENT DAYS FOR EVIDENCE OF AN INCREASE OR FOR A CONTINUING RISE IN LEVELS. INCREASED PHENYTOIN LEVELS SHOULD BE TREATED WITH APPROPRIATE DOSAGE ADJUSTMENT.

It may be necessary to adjust the dosage of oral anticoagulants upon beginning or stopping Disulfiram, since Disulfiram may prolong prothrombin time.

Patients taking isoniazid when Disulfiram is given should be observed for the appearance of unsteady gait or marked changes in mental status, the Disulfiram should be discontinued if such signs appear.

In rats, simultaneous ingestion of Disulfiram and nitrite in the diet for 78 weeks has been reported to cause tumors, and it has been suggested that Disulfiram may react with nitrites in the rat stomach to form a nitrosamine, which is tumorigenic. Disulfiram alone in the rat’s diet did not lead to such tumors. The relevance of this finding to humans is not known at this time.

Usage in Pregnancy:

The safe use of this drug in pregnancy has not been established. Therefore, Disulfiram should be used during pregnancy only when, in the judgment of the physician, the probable benefits outweigh the possible risks.

Pediatric Use:

Safety and effectiveness in pediatric patients have not been established.

Nursing Mothers:

It is not known whether this drug is excreted in human milk. Since many drugs are so excreted, Disulfiram should not be given to nursing mothers.

Geriatric Use:

A determination has not been made whether controlled clinical studies of Disulfiram included sufficient numbers of subjects aged 65 and over to define a difference in response from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal or cardiac function, and of concomitant disease or other drug therapy.

ADVERSE REACTIONS:

OPTIC NEURITIS, PERIPHERAL NEURITIS, POLYNEURITIS, AND PERIPHERAL NEUROPATHY MAY OCCUR FOLLOWING ADMINISTRATION OF Disulfiram.

Multiple cases of hepatitis, including both cholestatic and fulminant hepatitis, as well as hepatic failure resulting in transplantation or death, have been reported with administration of Disulfiram.

Occasional skin eruptions are, as a rule, readily controlled by concomitant administration of an antihistaminic drug.

In a small number of patients, a transient mild drowsiness, fatigability, impotence, headache, acneform eruptions, allergic dermatitis, or a metallic or garlic-like aftertaste may be experienced during the first two weeks of therapy. These complaints usually disappear spontaneously with the continuation of therapy, or with reduced dosage.

Psychotic reactions have been noted, attributable in most cases to high dosage, combined toxicity (with metronidazole or isoniazid), or to the unmasking of underlying psychoses in patients stressed by the withdrawal of alcohol.

To report SUSPECTED ADVERSE REACTIONS. contact Rising Pharmaceuticals at 1-866-562-4597 or FDA at 1-800-FDA-1088 or www. fda. gov/medwatch.

OVERDOSAGE:

No specific information is available on the treatment of overdosage with Disulfiram. It is recommended that the physician contact the local Poison Control Center.

DOSAGE AND ADMINISTRATION:

Disulfiram should never be administered until the patient has abstained from alcohol for at least 12 hours.

Initial Dosage Schedule:

In the first phase of treatment, a maximum of 500 mg daily is given in a single dose for one to two weeks. Although usually taken in the morning, Disulfiram may be taken on retiring by patients who experience a sedative effect. Alternatively, to minimize, or eliminate, the sedative effect, dosage may be adjusted downward.

Maintenance Regimen:

The average maintenance dose is 250 mg daily (range, 125 to 500 mg), it should not exceed 500 mg daily.

Note: Occasionally patients, while seemingly on adequate maintenance doses of Disulfiram, report that they are able to drink alcoholic beverages with impunity and without any symptomatology. All appearances to the contrary, such patients must be presumed to be disposing of their tablets in some manner without actually taking them. Until such patients have been observed reliably taking their daily Disulfiram tablets (preferably crushed and well mixed with liquid), it cannot be concluded that Disulfiram is ineffective.

Duration of Therapy:

The daily, uninterrupted administration of Disulfiram must be continued until the patient is fully recovered socially and a basis for permanent self-control is established. Depending on the individual patient, maintenance therapy may be required for months or even years.

Trial with Alcohol:

During early experience with Disulfiram, it was thought advisable for each patient to have at least one supervised alcohol-drug reaction. More recently, the test reaction has been largely abandoned. Furthermore, such a test reaction should never be administered to a patient over 50 years of age. A clear, detailed and convincing description of the reaction is felt to be sufficient in most cases.

However, where a test reaction is deemed necessary, the suggested procedure is as follows:

After the first one to two weeks’ therapy with 500 mg daily, a drink of 15 mL (1/2 oz) of 100 proof whiskey, or equivalent, is taken slowly. This test dose of alcoholic beverage may be repeated once only, so that the total dose does not exceed 30 mL (1 oz) of whiskey. Once a reaction develops, no more alcohol should be consumed. Such tests should be carried out only when the patient is hospitalized, or comparable supervision and facilities, including oxygen, are available.

Management of Disulfiram-Alcohol Reaction:

In severe reactions, whether caused by an excessive test dose or by the patient’s unsupervised ingestion of alcohol, supportive measures to restore blood pressure and treat shock should be instituted. Other recommendations include: oxygen, carbogen (95% oxygen and 5% carbon dioxide), vitamin C intravenously in massive doses (1 g) and ephedrine sulfate. Antihistamines have also been used intravenously. Potassium levels should be monitored, particularly in patients on digitalis, since hypokalemia has been reported.

HOW SUPPLIED:

Disulfiram Tablets, USP:

250 mg - White, capsule shaped tablets debossed “Σ 28” on one side and plain on the other side. They are available in bottles of 30’s (NDC 64980-171-03).

500 mg - White, capsule shaped bisected tablets debossed with “Σ” and “29” on either side of the bisection and plain on the other side. They are available in bottles of 30’s (NDC 64980-172-03).

Dispense in original container. Do not remove desiccant and adsorbent canisters from the bottle. Store at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature].

Manufactured by: Sigmapharm Laboratories, LLC Bensalem, PA 19020

Disulfiram 250 mg Container Label

Disulfiram Tablets, USP

Proscar - Man S Health, Chibro-Proscar

Finasteride is used to treat Benign prostatic hyperplasia (BPH) also known as benign enlargement of the prostate (BEP). This medicine helps to control your symptoms, diminish urinary retention and reduced your risk of needing the surgery.

Dosage and direction Take Proscar by mouth with a glass of water, with or without food. Avoid cutting, crushing or chewing this medicine. Consult your doctor concerning proper dose for you.

Before taking Proscar tell your doctor or chemist if you are allergic to Finasteride or Dutasteride; or if you have other allergies. As this medicament can be absorbed by skin, women who are pregnant or may become pregnant should not manipulate this medicine.

Contraindications Proscar should not be used by women or children as well as by the patients who have demonstrated a reaction of hypersensitivity to Finasteride.

Possible side effect The most common side effects are dizziness, unusual weakness, drowsiness, troubled sleeping, blurred vision, runny nose, or problems ejaculating. Stop using Proscar and call your doctor at once if you have any of these serious side effects: penis erection that is painful or lasts 4 hours or longer, severe dizziness or fainting. A very serious allergic reaction rarely occurs. In case you notice the effects not listed here, contact your doctor or pharmacist.

Drug interaction No drug interactions of clinical importance have been identified. Tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use before using this medication.

Missed dose If you have missed your dose, take it as soon as you remember. If you see that it is near the time for the next dose, skip the missed dose and resume your usual dosing schedule. Do not take your dose twice.

Overdose If you think you have used too much of this medicine, seek emergency medical attention right away. The symptoms of overdose usually include chest pain, nausea, irregular heartbeat, and feeling light-headed or fainting.

Storage Store your medicines at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture. Do not store them in the bathroom. Keep all drugs away from reach of children and pets.

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. The specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Pribalovy Letak Jenamazol 2%, Jenamazol

Pribalovy letak JENAMAZOL 2%

Humanni lecivy pripravek

JENAMAZOL 2%

vaginalni krem (Clotrimazolum)

Prectete si pozorne tento pribalovy letak, protoze obsahuje pro vas dulezite udaje. Tento pripravek je dostupny bez lekarskeho predpisu. Presto vsak pripravek JENAMAZOL 2% musite pouzivat peclive podle navodu, aby Vam co nejvice prospel.

Ponechte si pribalovy letak pro pripad, ze si jej budete potrebovat precist znovu.

Pozadejte sveho lekarnika, pokud potrebujete dalsi informace nebo radu.

Pokud se vase priznaky zhorsi nebo se nezlepsi do 5 dnu, musite se poradit s lekarem.

Pokud se kterykoli z nezadoucich ucinku vyskytne v zavazne mire, nebo pokud si vsimnete jakychkoli nezadoucich ucinku, ktere nejsou uvedeny v teto pribalove informaci, prosim, sdelte to svemu lekari.

V pribalovem letaku naleznete:

Co je JENAMAZOL 2% a k cemu se pouziva.

Cemu musite venovat pozornost, nez zacnete vaginalni krem JENAMAZOL 2% pouzivat.

Jak se JENAMAZOL 2% pouziva.

Mozne nezadouci ucinky.

Jak JENAMAZOL 2% uchovavat.

Dalsi informace.

1. CO JE PRIPRAVEK JENAMAZOL 2% A K CEMU SE POUZIVA

Charakteristika Jenamazol 2%, vaginalni krem, je sirokospektre antimykotikum, pusobici proti rade choroboplodnych houbovitych mikroorganizmu, vcetne dermatofytu, kvasinek a plisni. Navic pusobi proti bicikovci posevnimu (Trichomonas vaginalis) a nekterym druhum bakterii.

Indikace Nasledujici indikace s uvedenymi priznaky je pacientka schopna si diagnostikovat sa­ma:

vaginalni mykoza nebo zanety pochvy vyvolane choroboplodnymi houbami (obvykle kvasinkami);

posevni vytok podmineny kvasinkovou infekci (obvykle Candidou);

kandidovy zanet vulvy.

Hlavnimi priznaky vyse uvedenych indikaci je svedeni a/nebo bodani ci paleni casto provazene zluto-bilym vytokem vetsinou bez zapachu. Muze dojit i ke zdureni a zarudnuti v okoli vulvy a vaginalniho otvoru. Zanet s lokalnimi priznaky, ktery nema zadne sekundarni ucinky, ovlivnuje nepriznive celkovy dobry pocit pacienta a jeho pracovni vykon. Tento stav je charakterizovan akutnim nastupem priznaku, ktere se zhorsuji postupne nebo se vyskytnou nahle s vetsi intenzitou.

kandidovy zanet zaludu pohlavniho udu (balanitida)

Sexualni partner, u ktereho se objevi zanet zaludu vyvolany kvasinkami, by mel take podstoupit lecbu. Tuto indikaci je muz schopen si diagnostikovat sam. V nejlehci a nejtypictejsi forme se projevuje zarudnutim, svedenim, pachnoucim vytokem z predkozkove­ho vaku.

Pri nasledujicich priznacich by pripravek mela pacientka uzivat pouze po porade s lekarem:

pokud se vyse uvedene priznaky vyskytnou u pacientky poprve,

pokud se mykoticke infekce stejneho druhu vyskytnou vice nez 4? v poslednich 12ti mesicich,

priznaky odlisne od vyse uvedenych (necekane krvaceni nebo krvavy vytok, zapachajici, hnisavy a/nebo vodovy vytok, vredy, puchyre nebo bolest v genitani oblasti, bolest panve nebo bolest pri moceni, horecka nebo zimnice).

Pri lecbe infekce vyvolane trichomonadami (Trichomonas vaginalis) je nutna soucasna lecba vhodnymi antibiotiky podle doporuceni osetrujiciho lekare.

Ozdraveni porodnich cest v poslednich 4–6 tydnech tehotenstvi.

2. CEMU MUSITE VENOVAT POZORNOST, NEZ ZACNETE JENAMAZOL 2% POUZIVAT

Pripravek se nesmi pouzivat pri precitlivelosti vuci klotrimazolu nebo na nekterou slozku kremoveho zakladu. Pripravek by se nemel pouzivat u divek do 12 let. V tehotenstvi (napr. pri ozdraveni porodnich cest v poslednich 4–6 tydnech tehotenstvi) a v obdobi kojeni musi o vhodnosti lecby pripravkem Jenamazol 2% rozhodnout a pripadne zavedeni v tehotenstvi provest lekar. Lecba by nemela byt provadena behem menstruace, popripade by mela byt ukoncena jeste pred jejim zacatkem.

Vzajemne pusobeni s dalsimi lecivymi pripravky Bez porady s lekarem nepouzivejte soucasne zadne volne prodejne pripravky pro mistni lecbu sveho onemocneni. Pokud Vam bude lekar predepisovat nejaky jiny lek, informujte ho, ze pouzivate JENAMAZOL 2%, vaginalni krem.

Tehotenstvi a kojeni V tehotenstvi (napr. pri ozdraveni porodnich cest v poslednich 4 – 6 tydnech a v obdobi kojeni musi o vhodnosti lecby pripravkem JENAMAZOL 2% rozhodnout a pripadne zavedeni vaginalniho kremu v tehotenstvi provest lekar.

3. JAK SE JENAMAZOL 2% POUZIVA

Obsah 1 aplikatoru vaginalniho kremu (asi 5 g) se zavadi kazdy vecer 3 po sobe nasledujici dny. Kandidovy zanet vulvy/Kandidovy zanet zaludu (balanitida): Jenamazol 2%, vaginalni krem se tence nanese na postizene oblasti (na zevni pohlavni organy az ke konecniku u zen, na zalud a predkozku u muzu) 2–3krat denne a vetre se. Normalni doba lecby je 1–2 tydny. V pripade potreby lze lecbu zopakovat. Protoze obvykle jsou postizene jak vagina, tak i vulva, kombinovana lecba (lecba obou techto oblasti) by mela probihat soucasne. Lecba by nemela probihat behem menstruace, ale mela by skoncit do zacatku menstruace. Pripravek by se nemel pouzivat u divek do 12 let. Pri lecbe pripravkem Jenamazol 2% behem tehotenstvi musi aplikaci provadet lekar. Vaginalni krem by mel byt vecer zaveden do pochvy tak hluboko, jak je to jen mozne. Aplikace kremu se nejlepe docili v poloze na zadech s lehce natazenyma nohama.

Zpusob pouziti Zavedeni vaginalniho kremu pomoci aplikatoru:

Umyjte si peclive ruce

Aplikator vyjmete z baleni. Tycinku vytahnete z aplikatoru nadoraz.

Otevrete tubu. Pripojte aplikator k tube, drzte je pevne u sebe a naplnte aplikator opatrnym mackanim tuby.

Odpojte aplikator od tuby. Zavedte aplikator do pochvy tak hluboko, jak je to mozne (nejsnadneji vleze na zadech) a vyprazdnete obsah do pochvy tlacenim pistu.

Vyndejte aplikator a znehodnotte ho.

Predavkovani Pri predavkovani nebo nahodnem poziti pripravku ditetem se poradte s lekarem

Upozorneni Jenamazol 2% vaginalni krem muze snizit bezpecnost antikoncepcnich metod, napr. pri uziti spermicidnich pripravku, kondomu a nebo pesaru. Tento vliv je docasny a pretrvava pouze v dobe lecby. Leceni nema byt provadeno tesne pred nebo behem menstruace. Sexualni partner by mel take podstoupit lecbu, a to nejen pokud ma priznaky infekce, napr. svedeni, zanet. Lecba obou sexualnich partneru predchazi vzniku opakovane infekce (reinfekce). Pri zhorseni priznaku vyhledejte lekare a konzultujte s nim dalsi lecbu. Lecba jednim balenim vaginalniho kremu JENAMAZOL 2% (3 dny) je obycejne dostacujici k odstraneni mykoticke infekce. Pokud je to ale nutne, je mozne cyklus jeste jednou opakovat. Priznaky se obvykle podstatne zlepsi po 3–4 dnech od zahajeni terapie a vyresi se kompletne kratce pote. Pokud se vnejsi priznaky infekce uplne neodstrani po dokonceni terapie, je nutne vyhledat lekare.

Mate-li jakekoli dalsi otazky, tykajici se pouzivani tohoto pripravku, zeptejte se sveho lekare nebo lekarnika.

4. MOZNE NEZADOUCI UCINKY

Podobne jako vsechny leky, muze mit i JENAMAZOL 2%, nezadouci ucinky, ktere se ale nemusi vyskytnout u kazdeho. Vzacne se mohou vyskytnout mistni reakce jako je napr. paleni, bodave pocity nebo zarudnuti a svedeni sliznice. O vyskytu techto nebo jinych neobvyklych reakci informujte sveho lekare. Pokud se kterykoli z nezadoucich ucinku vyskytne v zavazne mire, nebo pokud si vsimnete jakychkoli nezadoucich ucinku, ktere nejsou uvedeny v teto pribalove informaci, prosim, sdelte to svemu lekari.

5. JAK JENAMAZOL 2% UCHOVAVAT

Uchovavejte pri teplote do 25 °C. Uchovavejte mimo dosah a dohled deti Pripravek JENAMAZOL 2% nepouzivejte po uplynuti doby pouzitelnosti, uvedene na krabicce i tube. Doba pouzitelnosti se vztahuje k poslednimu dni uvedeneho mesice. Lecive pripravky se nesmi vyhazovat do odpadnich vod nebo domaciho odpadu. Zeptejte se sveho lekarnika, jak mate likvidovat pripravky, ktere jiz nepotrebujete. Tato opatreni pomahaji chranit zivotni prostredi.

6. DALSI INFORMACE

Co JENAMAZOL 2% obsahuje Lecivou latkou je: Clotrimazolum 0,02 g v 1 g vaginalniho kremu, obsah aplikatoru (asi 5 g kremu) odpovida 0,1 g Clotrimazolum. Pomocnymi latkami jsou: sorbitan-stearat, polysorbat 60, vorvanovina, cetylstearylal­kohol, benzylalkohol, oktyldodekanol, cistena voda.

Jak pripravek JENAMAZOL 2% vypada a co obsahuje toto baleni Tuba s 20 g vaginalniho kremu a 3 aplikatory.

Drzitel rozhodnuti o registraci Quintesence s. r.o. Tenisova 845/6, 102 00 Praha 10 Ceska republika Tel. +42 606499073 E-mail: ganev@ quintesence. cz

Vyrobce WAKE s. r.o. Arbesova 797/III Rokycany Ceska republika

Datum posledni revize 16.9.2009

Vice informaci o lecivem pripravku naleznete zde .

Upozorneni: Vyse uvedene udaje maji pouze informacni charakter. Kompletni a aktualni informace o lecivych pripravcich naleznete na webovych strankach Statniho ustavu pro kontrolu leciv www. sukl. cz .

O spravnem davkovani nebo nezadoucich ucincich se poradte se svym lekarem nebo lekarnikem.

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5-Year Impact Factor: 2.808 ? Five-Year Impact Factor: 2015: 2.808 To calculate the five year Impact Factor, citations are counted in 2015 to the previous five years and divided by the source items published in the previous five years. © Journal Citation Reports 2016, Published by Thomson Reuters

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The Journal of Alloys and Compounds is intended to serve as an international medium for the publication of work on solid materials comprising compounds as well as alloys . Its great strength lies in the diversity of discipline which it encompasses, drawing together results from materials science . solid-state chemistry and physics . The interdisciplinary nature of the journal is evident in many subject areas. Experimental and theoretical approaches to materials problems require an active interplay between a variety of traditional and novel scientific disciplines. In much of the work published in the journal, synthetic and structural studies are combined with investigations of chemical and physical properties of alloys and compounds, contributing to the development of areas of current scientific interest. Papers submitted for publication should contain new experimental or theoretical results. The Journal of Alloys and Compounds provides a unique international forum where materials scientists.

The Journal of Alloys and Compounds is intended to serve as an international medium for the publication of work on solid materials comprising compounds as well as alloys . Its great strength lies in the diversity of discipline which it encompasses, drawing together results from materials science . solid-state chemistry and physics . The interdisciplinary nature of the journal is evident in many subject areas. Experimental and theoretical approaches to materials problems require an active interplay between a variety of traditional and novel scientific disciplines. In much of the work published in the journal, synthetic and structural studies are combined with investigations of chemical and physical properties of alloys and compounds, contributing to the development of areas of current scientific interest. Papers submitted for publication should contain new experimental or theoretical results. The Journal of Alloys and Compounds provides a unique international forum where materials scientists, chemists and physicists can present their results both to workers in their own fields and to others active in related areas.

The journal will not consider topics on casting, liquid alloys, wear, creep, welding, conducting polymers, purely synthetic papers without any properties, coordination chemistry, ionic liquids, catalysis, biochemistry, and organic materials.

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