Oracefal - Drug Review Dosage, Side Effects, Action, Buy Oracefal, Oracefal

Oracefal

Oracefal review

Oracefal . a broad-spectrum antibiotic, is effective against a variety of bacteria, including Gram-positive and Gram-negative bacteria. It belongs to a group of medicaments called cephalosporin antibiotics, used to treat many different types of bacterial infections from mild to moderate. It is not effective against viral infections including colds or the flu. Oracefal can be used as an antibiotic prophylaxis for dental procedures. Oracefal acts via quick absorption in the gastrointestinal tract, even when taken with food. It travels through the body to seek out traces of bacterial infection and attack them.

Patients should tell their physician if they are allergic to penicillin or other types of antibiotics prior to taking this medicament. Patients with a history of kidney disease, or any stomach or gastrointestinal tract disorder like colitis should tell their physician, because these conditions require a different dosage and close monitoring while taking this medicament.

Additionally, patients need to tell their physician if they have diabetes. Since Oracefal in liquid form (suspension) contains sucrose, it would not be the ideal medicament for a patient with diabetes. Although this medicament is not harmful to unborn babies, it is still important to let the physician know if the patient is pregnant or plans to become pregnant during the course of treatment.

Patients should tell their physician of any prescription or over-the-counter medicaments, including vitamin and herbal products. These may have negative results when taken with Oracefal. Some products may lessen the medicament's healing effect.

Oracefal is known by its fast absorbing action and may affect breast milk, causing harm to nursing infants. Patients should tell their physician if they are breastfeeding before starting Oracefal.

Symptoms of an infection usually clear before the bacteria are eradicated. Oracefal should be taken for the prescribed length of time to prevent a recurrence of the same infection in the future.

Antibiotics may cause diarrhea. which is often a sign of a new infection. If the diarrhea is exceptionally watery or contains blood. patients should call their physician and refrain from taking any medicament for the diarrhea unless told by a physician to do so.

Other known side effects include an upset stomach, mild nausea. arthralgia, and vaginal itching or discharge. If the medicament causes hives. breathing difficulties or skin edema of the face and mouth area, emergency medical attention should be sought immediately.

In some cases, the patient will experience extreme blistering and peeling, a red skin rash, fever and chills, throat soreness and flu symptoms, unexplained bleeding or bruising, nausea and loss of appetite. jaundice, dark urine and grey-colored stools, and even seizures. These side effects are serious and need to be reported to the physician as soon as possible.

Oracefal is taken as prescribed, usually with a full glass of water or milk. The liquid form of the medicament should be measured with a measuring spoon or cup to ensure the proper dose. Oracefal should be taken at regular intervals over the prescribed period of time for the best results.

Oracefal has the following structural formula:

• Molecular formula of oracefal is C16H17N3O5S • Chemical IUPAC Name is 7-[[2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3-methyl-8-oxo - 5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid • Molecular weight is 363.3883 g/mol • Oracefal available. 250mg tablets, 500mg tablets

Generic name: Cefadroxil

Allopurinol Oral Uses, Side Effects, Interactions, Pictures, Warnings - Dosing, Purinol

allopurinol

Uses

Allopurinol is used to treat gout and certain types of kidney stones. It is also used to prevent increased uric acid levels in patients receiving cancer chemotherapy. These patients can have increased uric acid levels due to release of uric acid from the dying cancer cells. Allopurinol works by reducing the amount of uric acid made by the body. Increased uric acid levels can cause gout and kidney problems.

How to use allopurinol

Take this medication by mouth. usually once daily or as directed by your doctor. Take this medication after a meal to reduce stomach upset. If your dose is more than 300 milligrams a day, you will need to take several smaller doses during the day to get this amount (ask your doctor for directions).

It is best to drink a full glass of water with each dose and at least 8 more glasses (8 ounces each) of fluid a day. If your doctor has directed you to drink less fluid for other medical reasons, consult your doctor for further instructions. Your doctor may also instruct you on how to decrease acid in your urine (e. g. avoiding large amounts of ascorbic acid /vitamin C ).

Dosage is based on your medical condition and response to treatment. Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day.

For the treatment of gout. it may take up to several weeks for this medicine to have an effect. You may have more gout attacks for several months after starting this medicine while the body removes extra uric acid. Allopurinol is not a pain reliever. To relieve pain from gout, continue to take your prescribed medicines for gout attacks (e. g. colchicine. ibuprofen. indomethacin ) as directed by your doctor.

Tell your doctor if your condition persists or worsens.

Side Effects

Stomach upset, nausea. diarrhea. or drowsiness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if any of these rare but very serious side effects occur: numbness/tingling of arms/legs, easy bleeding/bruising, signs of infection (e. g. fever, persistent sore throat ), unusual tiredness, signs of kidney problems (such as change in the amount of urine, painful/bloody urination), yellowing eyes /skin. severe stomach/abdominal pain. persistent nausea/vomiting. dark urine, unusual weight loss. eye pain. vision changes.

A very serious (possibly fatal) allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction. including: rash. itching /swelling (especially of the face/tongue /throat), severe dizziness. trouble breathing .

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking allopurinol, tell your doctor or pharmacist if you are allergic to it; or if you have had a severe reaction to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease. diabetes. high blood pressure (hypertension ), unusual diets (e. g. fasting ).

This drug may make you drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely.

Alcohol may decrease the effectiveness of this drug. Limit alcoholic beverages.

Kidney function declines as you grow older. This medication is removed by the kidneys. Therefore, older adults may be at greater risk for side effects while using this drug.

During pregnancy. this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

Allopurinol passes into breast milk. Consult your doctor before breast - feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (such as prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug are: certain asthma drugs (aminophylline, theophylline), azathioprine, "blood thinners" (e. g. warfarin), chlorpropamide, cyclosporine, didanosine, mercaptopurine.

Overdose

If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Notes

Do not share this medication with others.

Laboratory and/or medical tests (e. g. uric acid blood levels, liver/kidney function tests, complete blood count) may be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

If you are taking allopurinol to treat kidney stones, you may benefit from a special diet. Consult your doctor for more details.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store the US product at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture. Do not store in the bathroom.

Store the Canadian product at room temperature between 59-86 degrees F (15-30 degrees C) away from light and moisture.

Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Information last revised May 2016. Copyright(c) 2016 First Databank, Inc.

Images

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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Buy Anthelmin (Vermox) Online No Prescription, Anthelmin

Buy Anthelmin (Vermox) without Prescription

Anthelmin Marketing Information

Anthelmin Description

Generic Anthelmin is used to treat infections caused by worms such as whipworm, pinworm, roundworm, and hookworm. It is also used to treat infections caused by more than one of these worms at the same time.

Generic Anthelmin is an antihelmintic, or anti-worm, medication. It prevents worms from growing or multiplying in your body.

Generic name of Generic Anthelmin is Mebendazole.

Brand name of Generic Anthelmin is Anthelmin.

Anthelmin Dosage

Generic Anthelmin is available in:

100mg Standard Dosage

Generic Anthelmin tablets may be swallowed, chewed, or crushed and mixed with food.

It may be up to 3 days after treatment before the worm is removed from your stomach and intestines. The amount of time it takes to cure the infection depends on how susceptible the worm is to Generic Anthelmin, and how quickly your own digestive system is moving. If the infection has not been cured within 3 weeks, a second treatment may be necessary.

Treatment of family members and other close contacts may be necessary. Pinworm is spread very easily to others in close contact with the infected person.

If you want to achieve most effective results do not stop taking Generic Anthelmin suddenly.

Anthelmin Missing of dose

Do not take double dose. If you miss a dose you should take it as soon as you remember about your missing. If it is the time for the next dose you should continue your regular dosing schedule.

Anthelmin Overdose

If you overdose Generic Anthelmin and you don't feel good you should visit your doctor or health care provider immediately.

Anthelmin Side effects

Generic Anthelmin has its side effects. The most common are:

Less common but more serious side effects during taking Generic Anthelmin: allergy reactions (urticaria, breathing difficulties, rash, and eruption).

Side effects manifestations are not only depend on medicine you are taking but also depend on your health state and on the other factors.

Anthelmin Contra-indications

Do not take Generic Anthelmin if you are allergic to Generic Anthelmin components.

Do not take Generic Anthelmin if you are pregnant, planning to become pregnant. Do not breast-feed while taking Generic Anthelmin.

Children younger than 2 years of age should not take mebendazole unless otherwise directed by your doctor.

It can be dangerous to stop Generic Anthelmin taking suddenly.

Anthelmin Frequently asked questions

Q: What does Generic Anthelmin mean?

A: Generic Anthelmin is used to treat infections caused by worms such as whipworm, pinworm, roundworm, and hookworm. It is also used to treat infections caused by more than one of these worms at the same time.

Q: What are brand and generic names of Generic Anthelmin?

A: Generic name of Generic Anthelmin is Mebendazole. Brand name of Generic Anthelmin is Anthelmin.

Q: In what way does Generic Anthelmin operate?

A: Generic Anthelmin is an antihelmintic, or anti-worm, medication. It prevents worms from growing or multiplying in your body.

Q: Can pregnant women use Generic Anthelmin?

A: Do not take Generic Anthelmin if you are pregnant, planning to become pregnant. Do not breast-feed while taking Generic Anthelmin.

Flexase, Flexase

Flexase

Important Notice: The Drugs. com international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

Was this page helpful?

Common use Feldene is a non-steroidal anti-inflammatory drug, which is used to treat rheumatoid arthritis or osteoarthritis. Feldene reduces hormones that cause inflammation and pain in the body.

Dosage and direction

Consult your doctor before using. Use no more than was prescribed. Take it orally with food or milk. For osteoarthritis and rheumatoid arthritis the recommended dose is 20 milligrams (mg) once a day or 10 mg twice a day. Do not use this medication in children without a doctor's permission. Note: this instruction presented here is just for review. It's very necessary to consult your doctor before using. It will help you to get best results.

Precautions If you have heart disease, or high blood pressure, or other conditions that cause fluid retention, use Feldene with caution. This medication can increase water retention and is not recommended for people with advanced kidney disease, also Feldene cause liver damage. Also medications such as Feldene may cause eye disturbances in some patients. If you develop visual problems, tell your eye doctor. Feldene can increase the risk of serious stomach or bowel problems. If your health is poor, if you have a history of smoking or drinking alcohol, if you take corticosteroid medicines or "blood thinners", or if you take this medicine for a long period of time the risk of taking Feldene will be increased. Feldene should not be used during pregnancy ( if becoming pregnant) or when lactating without doctor's advice. Do not use Feldene before breast-feeding without doctor's advice.

Contraindications Feldene is not allowed in people with active peptic ulcer, inflammatory gastrointestinal disorder, gastrointestinal bleeding or hypersensitive to Feldene, Aspirin, or similar drugs. Also if you have had asthma attacks caused by Aspirin or other drugs of this type, you should not take this medication. Do not use Feldene for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery.

Possible side effects They may include all types of an allergic reaction. Also the most possible side effects include: weakness, chest pain, shortness of breath, problems with vision or balance, slurred speech; bloody, black, or tarry stools; coughing up blood or vomit that looks like coffee grounds; swelling or rapid weight gain; urinating less than usual or not at all; dark urine, nausea, low fever, loss of appetite, clay-colored stools, jaundice, stomach pain; fever, sore throat, and headache with a severe blistering, peeling, and red skin rash; bruising, severe tingling, numbness, pain, muscle weakness; fever, headache, neck stiffness, chills, increased sensitivity to light, purple spots on the skin, and/or seizure. Less serious include: upset stomach, mild heartburn or stomach pain, diarrhea, constipation; bloating, gas; dizziness, headache, nervousness; skin itching or rash; blurred vision; ringing in your ears. If you experience one of them stop using Feldene and tell your doctor as soon as possible. Also consult your doctor about any side effect that seems unusual.

Drug interaction Feldene interacts with the following drugs: a blood thinner such as warfarin; lithium; methotrexate; diuretics such as furosemide; steroids; aspirin or other NSAIDs such as etodolac, flurbiprofen, indomethacin, ketoprofen, ketorolac, mefenamic acid, meloxicam, nabumetone, naproxen, and others; an ACE inhibitor such as benazepril, captopril, fosinopril, enalapril, lisinopril, ramipril, and others. Also note that interaction between two medications does not always mean that you must stop taking one of them. As usual it affects the effect of drugs, so consult your doctor about how the way these interactions are being managed or should be managed.

Missed dose If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not increase your recommended dose. Take your usual dose next day in the same regular time.

Overdose Symptoms of Feldene overdose may include: stomach pain, nausea, drowsiness, vomiting, black or bloody stools, shallow breathing, coughing up blood, fainting, or coma. If you experience one of them or any unusual symptoms call your doctor immediately.

Storage Store at room temperature between 20-25 C (68-77 F).

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Caprimida-D Forte - Proveedores, Fabricantes Y Distribuidores, Caprimida

Proveedores de Caprimida-d forte

Si usted desea saber quién vende, comercializa, distribuye u ofrece Caprimida-d forte o productos similares, a continuación le mostramos una lista de vendedores o comercializadores que son fabricantes (productores), exportadores, distribuidores y en general suplidores / proveedores de Caprimida-d forte. Para poder elegir mejor, en el listado puede ver de acuerdo a su ubicación donde comprar Caprimida-d forte, solicitar información, precios o una cotización a las empresas que venden, exportan, menejan, manufacturan, ofrecen o comercializan este producto.

Osteolab. Ofrecemos Caprimida-d forte en.

Actualizado: menos de una hora Contactar

Urbania Pest Control Solutions. Ofrecemos Agroquel forte 1kg. en 8 Oriente 2009 Col. Acocota, Puebla, Puebla C. P. 72050. Mexico.

Actualizado: hace 6 horas Contactar Llamar

Sehyex. Somos proveedores de GINGI FORTE PET en Cda. Alfredo del Mazo 4 - 1 Col. México Nuevo Ex Hacienda el Pedregal, Atizapán de Zaragoza, Estado de México C. P. 52966. Mexico.

Actualizado: hace 6 horas Contactar Llamar

Grupo Malla-Aceros. Somos un proveedor de Reja Forte en Camino a la Luz S/N Col. Zacatepec, Córdoba, Veracruz C. P. 94560. Mexico.

Actualizado: hace 3 horas Contactar Llamar

Janssen Farmaceutica. Somos proveedores de Stugeron forte / retard en Canoa 79 Col. Tizapán San Angel, MEXICO C. P. 1090. Mexico.

Actualizado: hace 3 horas Contactar Llamar

Siegfried Rhein. Ofrecemos Metoxiprim / forte en Presidente Mazarik 191 Col. piso 4, MEXICO Mexico.

Actualizado: hace 21 horas Contactar Llamar

Diverflow. Ofrecemos Divosan forte en.

Actualizado: hace 5 horas Contactar

Baux Chemical. Somos un proveedor de Divosan forte en Carrera 65B No. 12-71 Bogotá, Colombia Colombia.

Actualizado: hace 5 horas Contactar Llamar

Abbot Chile. Somos un proveedor de Pantomicina ees 200/ ees 400 forte en.

Actualizado: hace 4 horas Contactar

Abbott Argentina. Ofrecemos Klaricid forte en.

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Aventis Pharma Argentina. Somos proveedores de Iridus forte ap en.

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Beiersdorf. Ofrecemos Hidrofugal forte en.

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Benguerel. Somos proveedores de Elcal-d forte en 154 street Madison Bangkok, Bangkok Cameroon.

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Bestpharma. Ofrecemos Cotrimoxazol forte en.

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Silverlit Toys Manufactory Ltd, Silverit

For a perfect PiccoZ, play around the hinge axis on the main rotor should be zero, while beeing absolutely free to move around that same hinge. Easy to understand that this is nearly impossible to accomplisch in mass production. So most PiccoZ come with somewhat too much play to avoid that there is the slightest friction given variances in plastic schrinkage and assembly tolerances. For those who want to get the best results, there is a simple way of reducing the hinge play, altough if done the wrong way, it will make it fly worse.

So, on your own risk (no warranty), you could try the following.

First measure play by moving one blad tip up and down without bending. Take a metal rod of about 2mm diameter (not critical) and sharpen it to a tip like a pencil. Avoid to make it needle sharp or it will make holes in the plastic (that is not the purpose, see further). You can use the tip of a small phillips screwdriver too. Locate on top side of the rotor, about 3-4 mm each side of the central hole along the hinge axis. Beneath that are hidden the molded plastic hinge pins. Put one finger on the underside of the rotor for support, and CAREFULLY but FIRMLY press with the pin on the top side (right above the hinge pin) to make a small dent in the plastic. Do the same the other side. These dents actually reduce the gap between the plastic of the rotor and the hinge pin, reducing play. Do this in small steps, and check each time if play has been reduced, and if more could be done. It's better to stop too early rather than too late. In the latter case, there will be friction and that is a realy not what we want. There may be a way back, but I never had to try I have done it a couple of times and it's actually not too difficult for a carefull and delicate modeller's hand. It's best when play is 'just a little bit'.

Try it in case your PiccoZ does not has this 'solid' feel and you will be amazed.

Once that done, you can check if blade tips (with stabilizer rotor at 90degrees to the vertical rotor axis) are at 90 degrees to that axis too. If not bent one end till it does.

Last, check if incidence of one blade side equals that of the other side. If not, adjust one side at the root end by pressure (NOT at the tip)

Some small strips of tape on one end or the other can further help to smoothen out things.

I emphasise that this is at your own risk (if you screw it up), or satisfaction (if you succeed).

Doxysol

Doxysol

TABLETTER 100 mg: Hver tablett inneh. Doksycyklinmonohydrat aeqv. doksycyklin 100 mg.

Avhenger av infeksjonens art. Overskrides anbefalt dosering kan det medfore okt frekvens av bivirkninger. Enhver behandling bor fortsettes i 1-2 dogn etter symptom-, feberfrihet. Voksne og barn over 12 ar: Forste dogn 2 tabletter (200 mg), senere 1 tablett (100 mg) pr. dogn. Ved mer alvorlige/vanskelige tilfeller kan 2 tabletter gis pr. dogn under hele behandlingstiden. Tablettene tas til et lett maltid og rikelig drikke eller de slemmes ut i litt vann. Pase da at alt innholdet svelges. Ved langvarig behandling og leverinsuffisiens bor serumkonsentrasjonen folges og dosen justeres. Ved nedsatt nyrefunksjon kan doksycyklin gis i vanlig dosering. Spesielle infeksjoner: Chlamydia uretritt: 200 mg forste dag, deretter 100 mg daglig i 7-10 dager. Chlamydia salpingitt: 100 mg 2 ganger daglig i 10 dager. Ureaplasma urealyticum (T-mycoplasma) infeksjoner: 100 mg 2 ganger daglig (ogsa partner).Lavdosert tetracyklin. Overgang i placenta: Se Forsiktighetsregler. Bor ikke brukes av gravide pga. risiko for tannskader hos fosteret. Risiko for andre misdannelser kan heller ikke utelukkes. Overgang i morsmelk: Utskilles i morsmelk. Risiko for pavirkning av barnet er tilstede.

Forholdsregler, negative reaksjoner og kontraindikasjoner

Kan pga. sin affinitet til kalsium i voksende benvev, tenner og tannanlegg gi irreversible forandringer i emalje og tannsubstans, og reversible forandringer av benvev. Effekten er storst siste halvdel av svangerskapet og hos barn under 12 ar, hvor preparatet bare bor brukes unntaksvis og pa klare indikasjoner. For ovrig frarades bruk av tetracykliner i hele svangerskapet. I sjeldne tilfeller har osofagitt og ulcerasjon i oesophagus v?rt rapportert hos pasienter som har fatt perorale tetracyklinpreparater. Det er forelopig ikke rapportert for doksycyklinmonohydrat. En teoretisk risiko for at det kan skje, vil v?re minimal dersom tabletten pa forhand slemmes ut i litt vann, noe som spesielt kan v?re aktuelt hos pasienter som er sengeliggende eller har svelgeproblemer. Forsiktighet bor utvises ved leversykdom. Ved langtidsbehandling bor det gjores periodiske laboratorieundersokelser av blod, nyre - og leverfunksjon.

Seponer preparatet. Gi symptomatisk behandling og stotteterapi. Dialyse ikke ansett av verdi.

Progesterone (Professional Patient Advice), Progestan

Progesterone

Protein Binding

Albumin (50% to 54%) and cortisol-binding protein (43% to 48%)

Use: Labeled Indications

Oral: Prevention of endometrial hyperplasia in nonhysterectomized, postmenopausal women who are receiving conjugated estrogen tablets; secondary amenorrhea

IM: Amenorrhea; abnormal uterine bleeding due to hormonal imbalance

Intravaginal gel: Part of assisted reproductive technology (ART) for infertile women with progesterone deficiency; secondary amenorrhea

Vaginal insert: Part of ART for infertile women with progesterone deficiency

Use: Unlabeled

Reduce the risk of spontaneous preterm birth in women with singleton pregnancies who have either had a prior spontaneous preterm birth or who have a cervix <20 mm before or at 24 weeks gestation (ACOG, 2012).

Contraindications

Hypersensitivity to progesterone or any component of the formulation; undiagnosed abnormal vaginal bleeding; history of or current thrombophlebitis or venous thromboembolic disorders (including DVT, PE); active or history of arterial thromboembolic disease (eg, stroke, MI); history of or known or suspected carcinoma of the breast or genital organs; hepatic dysfunction or disease; missed abortion or ectopic pregnancy; diagnostic test for pregnancy; capsules are also contraindicated for use during pregnancy

Dosing: Adult

Amenorrhea: IM: 5 to 10 mg/day for 6 to 8 consecutive days

Intravaginal gel: 45 mg (4% gel) every other day for 6 doses; if response is inadequate, may increase to 90 mg (8% gel) at same schedule

Oral: 400 mg every evening for 10 days

ART in patients who require progesterone supplementation:

Intravaginal gel: 90 mg (8% gel) once daily. If pregnancy occurs, may continue treatment for 10 to 12 weeks.

Intravaginal insert: 100 mg 2 to 3 times daily starting at oocyte retrieval and continuing for up to 10 weeks.

ART in patients with partial or complete ovarian failure:

Intravaginal gel: 90 mg (8% gel) twice daily. If pregnancy occurs, continue treatment for 10 to 12 weeks.

Endometrial hyperplasia prevention (in postmenopausal women with a uterus who are receiving daily conjugated estrogen tablets): Oral: 200 mg as a single daily dose every evening for 12 days sequentially per 28-day cycle

Functional uterine bleeding: IM: 5 to 10 mg/day for 6 doses

Prevention of spontaneous preterm delivery (singleton pregnancy and prior preterm birth or short cervix) (off-label use): Intravaginal gel: 90 mg (8% gel) once daily (Hassan, 2011; O’Brien, 2009). Treatment initiation is recommended before or at gestational week 24 (ACOG, 2012).

Dosing: Geriatric

Refer to adult dosing.

Dosing: Renal Impairment

Injection, oral: There are no dosage adjustments provided in the manufacturer’s labeling (has not been studied). Use with caution.

Intravaginal gel, insert: There are no dosage adjustments provided in the manufacturer’s labeling.

Dosing: Hepatic Impairment

Use is contraindicated in liver dysfunction or disease.

Administration

IM: Administer deep IM only

Vaginal gel: (A small amount of gel will remain in the applicator following insertion): Administer into the vagina directly from sealed applicator. Remove applicator from wrapper; holding applicator by thickest end, shake down to move contents to thin end; while holding applicator by flat section of thick end, twist off tab; gently insert into vagina and squeeze thick end of applicator.

For use at altitudes above 2500 feet: Remove applicator from wrapper; hold applicator on both sides of bubble in the thick end; using a lancet, make a single puncture in the bubble to relieve air pressure; holding applicator by thickest end, shake down to move contents to thin end; while holding applicator by flat section of thick end, twist off tab; gently insert into vagina and squeeze thick end of applicator.

Vaginal insert: Insert tablet in vagina using disposable applicator provided.

Oral capsule: For patients who experience difficulty swallowing the capsules, taking with a full glass of water in the standing position may be beneficial.

Hazardous agent; use appropriate precautions for handling and disposal (NIOSH 2014 [group 2]) .

Storage

Store at controlled room temperature. Protect capsules from excessive moisture.

Drug Interactions

Afatinib: P-glycoprotein/ABCB1 Inhibitors may increase the serum concentration of Afatinib. Management: Per US labeling: reduce afatinib by 10mg if not tolerated. Per Canadian labeling: avoid combination if possible; if used, administer the P-gp inhibitor simultaneously with or after the dose of afatinib. Consider therapy modification

Anticoagulants: Progestins may diminish the therapeutic effect of Anticoagulants. More specifically, the potential prothrombotic effects of some progestins and progestin-estrogen combinations may counteract anticoagulant effects. Management: Carefully weigh the prospective benefits of progestins against the potential increased risk of procoagulant effects and thromboembolism. Use is considered contraindicated under some circumstances. Refer to related guidelines for specific recommendations. Consider therapy modification

Antidiabetic Agents: Hyperglycemia-Associated Agents may diminish the therapeutic effect of Antidiabetic Agents. Monitor therapy

Antifungal Agents (Vaginal): May diminish the therapeutic effect of Progesterone. Avoid combination

Bosentan: May decrease the serum concentration of CYP3A4 Substrates. Monitor therapy

Bosutinib: P-glycoprotein/ABCB1 Inhibitors may increase the serum concentration of Bosutinib. Avoid combination

Brentuximab Vedotin: P-glycoprotein/ABCB1 Inhibitors may increase the serum concentration of Brentuximab Vedotin. Specifically, concentrations of the active monomethyl auristatin E (MMAE) component may be increased. Monitor therapy

C1 inhibitors: Progestins may enhance the thrombogenic effect of C1 inhibitors. Monitor therapy

Colchicine: P-glycoprotein/ABCB1 Inhibitors may increase the serum concentration of Colchicine. Colchicine distribution into certain tissues (e. g. brain) may also be increased. Management: Colchicine is contraindicated in patients with impaired renal or hepatic function who are also receiving a p-glycoprotein inhibitor. In those with normal renal and hepatic function, reduce colchicine dose as directed. Consider therapy modification

CYP2C19 Inducers (Strong): May increase the metabolism of CYP2C19 Substrates. Management: Consider an alternative for one of the interacting drugs. Some combinations may be specifically contraindicated. Consult appropriate manufacturer labeling. Consider therapy modification

CYP3A4 Inducers (Moderate): May decrease the serum concentration of CYP3A4 Substrates. Monitor therapy

CYP3A4 Inducers (Strong): May increase the metabolism of CYP3A4 Substrates. Management: Consider an alternative for one of the interacting drugs. Some combinations may be specifically contraindicated. Consult appropriate manufacturer labeling. Consider therapy modification

Dabigatran Etexilate: P-glycoprotein/ABCB1 Inhibitors may increase serum concentrations of the active metabolite(s) of Dabigatran Etexilate. Management: Dabigatran dose reductions may be needed. Specific recommendations vary considerably according to US vs Canadian labeling, specific P-gp inhibitor, renal function, and indication for dabigatran treatment. Refer to full monograph or dabigatran labeling. Consider therapy modification

Dabrafenib: May decrease the serum concentration of CYP3A4 Substrates. Management: Seek alternatives to the CYP3A4 substrate when possible. If concomitant therapy cannot be avoided, monitor clinical effects of the substrate closely (particularly therapeutic effects). Consider therapy modification

Dabrafenib: May decrease the serum concentration of CYP2C19 Substrates. Management: Seek alternatives to the CYP2C19 substrate when possible. If concomitant therapy cannot be avoided, monitor clinical effects of the substrate closely (particularly therapeutic effects). Consider therapy modification

Deferasirox: May decrease the serum concentration of CYP3A4 Substrates. Monitor therapy

DOXOrubicin (Conventional): P-glycoprotein/ABCB1 Inhibitors may increase the serum concentration of DOXOrubicin (Conventional). Management: Seek alternatives to P-glycoprotein inhibitors in patients treated with doxorubicin whenever possible. One U. S. manufacturer (Pfizer Inc.) recommends that these combinations be avoided. Consider therapy modification

Edoxaban: P-glycoprotein/ABCB1 Inhibitors may increase the serum concentration of Edoxaban. Management: See full monograph for details. Reduced doses are recommended for patients receiving edoxaban for venous thromboembolism in combination with certain inhibitors. Similar dose adjustment is not recommended for edoxaban use in atrial fibrillation. Consider therapy modification

Enzalutamide: May decrease the serum concentration of CYP3A4 Substrates. Management: Concurrent use of enzalutamide with CYP3A4 substrates that have a narrow therapeutic index should be avoided. Use of enzalutamide and any other CYP3A4 substrate should be performed with caution and close monitoring. Consider therapy modification

Enzalutamide: May decrease the serum concentration of CYP2C19 Substrates. Conversely, concentrations of active metabolites may be increased for those drugs activated by CYP2C19. Management: Concurrent use of enzalutamide with CYP2C19 substrates that have a narrow therapeutic index should be avoided. Use of enzalutamide and any other CYP2C19 substrate should be performed with caution and close monitoring. Consider therapy modification

Everolimus: P-glycoprotein/ABCB1 Inhibitors may increase the serum concentration of Everolimus. Management: Everolimus dose reductions are required for patients being treated for subependymal giant cell astrocytoma or renal cell carcinoma. See prescribing information for specific dose adjustment and monitoring recommendations. Consider therapy modification

Herbs (Progestogenic Properties) (eg, Bloodroot, Yucca): May enhance the adverse/toxic effect of Progestins. Monitor therapy

Mitotane: May decrease the serum concentration of CYP3A4 Substrates. Management: Doses of CYP3A4 substrates may need to be adjusted substantially when used in patients being treated with mitotane. Consider therapy modification

Naloxegol: P-glycoprotein/ABCB1 Inhibitors may increase the serum concentration of Naloxegol. Monitor therapy

PAZOPanib: P-glycoprotein/ABCB1 Inhibitors may increase the serum concentration of PAZOPanib. Avoid combination

P-glycoprotein/ABCB1 Substrates: P-glycoprotein/ABCB1 Inhibitors may increase the serum concentration of P-glycoprotein/ABCB1 Substrates. P-glycoprotein inhibitors may also enhance the distribution of p-glycoprotein substrates to specific cells/tissues/organs where p-glycoprotein is present in large amounts (e. g. brain, T-lymphocytes, testes, etc.). Monitor therapy

Pomalidomide: Progestins may enhance the thrombogenic effect of Pomalidomide. Management: Canadian pomalidomide labeling recommends caution with use of hormone replacement therapy and states that hormonal contraceptives are not recommended. US pomalidomide labeling does not contain these specific recommendations. Consider therapy modification

Prucalopride: P-glycoprotein/ABCB1 Inhibitors may increase the serum concentration of Prucalopride. Monitor therapy

Ranolazine: P-glycoprotein/ABCB1 Inhibitors may increase the serum concentration of Ranolazine. Monitor therapy

RifAXIMin: P-glycoprotein/ABCB1 Inhibitors may increase the serum concentration of RifAXIMin. Monitor therapy

Silodosin: P-glycoprotein/ABCB1 Inhibitors may increase the serum concentration of Silodosin. Avoid combination

Siltuximab: May decrease the serum concentration of CYP3A4 Substrates. Monitor therapy

St John's Wort: May decrease the serum concentration of CYP3A4 Substrates. Management: Consider an alternative for one of the interacting drugs. Some combinations may be specifically contraindicated. Consult appropriate manufacturer labeling. Consider therapy modification

Tocilizumab: May decrease the serum concentration of CYP3A4 Substrates. Monitor therapy

Topotecan: P-glycoprotein/ABCB1 Inhibitors may increase the serum concentration of Topotecan. Avoid combination

Ulipristal: May diminish the therapeutic effect of Progestins. Progestins may diminish the therapeutic effect of Ulipristal. Management: Ulipristal for uterine fibroids (Canadian indication): avoid progestins within 12 days of stopping ulipristal; as emergency contraceptive (U. S. indication): avoid progestins within 5 days of stopping ulipristal. Avoid combination

Venetoclax: P-glycoprotein/ABCB1 Inhibitors may increase the serum concentration of Venetoclax. Management: Reduce the venetoclax dose by at least 50% in patients requiring these combinations. Consider therapy modification

VinCRIStine (Liposomal): P-glycoprotein/ABCB1 Inhibitors may increase the serum concentration of VinCRIStine (Liposomal). Avoid combination

Test Interactions

Thyroid function, metyrapone, liver function, coagulation tests, endocrine function tests

Adverse Reactions

Cardiovascular: Cerebral edema, cerebral thrombosis, edema

Central nervous system: Depression, fever, insomnia, somnolence

Dermatologic: Acne, allergic rash (rare), alopecia, hirsutism, pruritus, rash, urticaria

Endocrine & metabolic: Amenorrhea, breakthrough bleeding, breast tenderness, galactorrhea, menstrual flow changes, spotting

Gastrointestinal: Nausea, weight gain/loss

Genitourinary: Cervical erosion changes, cervical secretion changes

Hepatic: Cholestatic jaundice

Local: Injection site: Irritation, pain, redness

Ocular: Optic neuritis, retinal thrombosis

Respiratory: Pulmonary embolism

Miscellaneous: Anaphylactoid reactions

Oral capsule (percentages reported when used in combination with or cycled with conjugated estrogens):

Central nervous system: Headache (16% to 31%), dizziness (15% to 24%), depression (19%)

Endocrine & metabolic: Breast tenderness (27%), breast pain (6% to 16%)

Gastrointestinal: Abdominal pain (10% to 20%), abdominal bloating (8% to 12%)

Genitourinary: Urinary problems (11%)

Neuromuscular & skeletal: Joint pain (20%), musculoskeletal pain (12%)

Miscellaneous: Viral infection (12%)

Cardiovascular: Chest pain (7%)

Central nervous system: Fatigue (8%), irritability (8%), worry (8%)

Gastrointestinal: Nausea/vomiting (8%), diarrhea (7% to 8%)

Genitourinary: Vaginal discharge (10%)

Respiratory: Cough (8%)

<5%: Breast biopsy, breast cancer, cholecystectomy, constipation

Postmarketing and/or case reports: Aggression, alopecia, anaphylactic reaction, arthralgia, asthma, blurred vision, choking, cholestasis, cholestatic hepatitis, circulatory collapse, confusion, consciousness depressed/loss, convulsion, depersonalization, diplopia, disorientation, drunk feeling, dysarthria, dysphagia, dyspnea, endometrial carcinoma, facial edema, feeling abnormal, gait abnormal, hepatic enzymes increased, hepatic failure, hepatic necrosis, hepatitis, hyperglycemia, hyper-/hypotension, hypersensitivity, jaundice, liver function tests increased, menorrhagia, menstrual disorder, metrorrhagia, muscle cramps, ovarian cyst, pancreatitis (acute), paresthesia, pruritus, sedation, slurred speech, stupor, suicidal ideation, syncope, tachycardia, throat tightness, TIA, tinnitus, tongue swelling, urticaria, vertigo, visual disturbance, walking difficulty, weight gain/loss

Vaginal gel (percentages reported with ART); also refer to oral capsule reactions listing for additional effects noted with progesterone:

Central nervous system: Somnolence (27%), headache (13% to 17%), nervousness (16%), depression (11%)

Endocrine & metabolic: Breast enlargement (40%), breast pain (13%), libido decreased (11%)

Gastrointestinal: Constipation (27%), nausea (7% to 22%), cramps (15%), abdominal pain (12%)

Genitourinary: Perineal pain (17%), nocturia (13%)

Central nervous system: Pain (8%), dizziness (5%)

Gastrointestinal: Diarrhea (8%), bloating (7%), vomiting (5%)

Genitourinary: Vaginal discharge (7%), dyspareunia (6%), genital moniliasis (5%), genital pruritus (5%)

Neuromuscular & skeletal: Arthralgia (8%)

Vaginal insert (percentages reported with ART); also refer to oral capsule reactions listing for additional effects noted with progesterone:

Gastrointestinal: Abdominal pain (12%)

Miscellaneous: Post-oocyte retrieval pain (25% to 28%)

Central nervous system: Headache (3% to 4%), fatigue (2% to 3%)

Endocrine & metabolic: Ovarian hyperstimulation syndrome (7%)

Gastrointestinal: Nausea (7% to 8%), abdominal distension (4%), constipation (2% to 3%), vomiting (2% to 3%)

Genitourinary: Uterine spasm (3% to 4%), vaginal bleeding (3%), urinary tract infection (1% to 2%)

<1%: Burning, discomfort, itching, peripheral edema, urticaria, vaginal irritation

ALERT: U. S. Boxed Warning

Cardiovascular disease (capsule):

Do not use progestins plus estrogens for the prevention of cardiovascular disease.

The Women's Health Initiative (WHI) estrogen plus progestin substudy reported increased risks of myocardial infarction (MI), stroke, pulmonary embolism (PE), and deep vein thrombosis (DVT) in postmenopausal women (50 to 79 years of age) during 5.6 years of treatment with daily oral conjugated estrogens 0.625 mg combined with medroxyprogesterone acetate 2.5 mg relative to placebo.

Do not use progestins plus estrogens for the prevention of dementia.

The Women's Health Initiative Memory Study (WHIMS) estrogen plus progestin ancillary study of the WHI reported an increased risk of developing probable dementia in postmenopausal women 65 years and older during 4 years of treatment with daily conjugated estrogens 0.625 mg combined with medroxyprogesterone acetate 2.5 mg, relative to placebo. It is unknown whether this finding applies to younger postmenopausal women.

Breast cancer (capsule):

The WHI estrogen plus progestin substudy also demonstrated an increased risk of invasive breast cancer.

In the absence of comparable data, assume these risks to be similar for other doses of conjugated estrogens and medroxyprogesterone acetate and other combinations and dosage forms of estrogens and progestins.

Risks vs benefits (capsule):

Prescribe progestins with estrogens at the lowest effective doses and for the shortest duration consistent with treatment goals and risks for the individual woman.

Warnings/Precautions

Concerns related to adverse effects:

• Breast cancer: [US Boxed Warning]: Based on data from the Women’s Health Initiative (WHI) studies, an increased risk of invasive breast cancer was observed in postmenopausal women using conjugated estrogens (CE) in combination with medroxyprogesterone acetate (MPA). This risk may be associated with duration of use and declines once combined therapy is discontinued (Chlebowski, 2009). The risk of invasive breast cancer was decreased in postmenopausal women with a hysterectomy using CE only, regardless of weight. However, the risk was not significantly decreased in women at high risk for breast cancer (family history of breast cancer, personal history of benign breast disease) (Anderson, 2012). An increase in abnormal mammogram findings has also been reported with estrogen alone or in combination with progestin therapy. Use is contraindicated in patients with known or suspected breast cancer.

• CNS effects: Patients should be warned that progesterone might cause transient dizziness or drowsiness during initial therapy.

• Dementia: [US Boxed Warning]: Estrogens with or without progestin should not be used to prevent dementia. In the Women’s Health Initiative Memory Study (WHIMS), an increased incidence of dementia was observed in women ?65 years of age taking CE alone or in combination with MPA .

• Endometrial cancer: Progesterone is used to reduce the risk of endometrial hyperplasia in nonhysterectomized postmenopausal women receiving conjugated estrogens. The use of unopposed estrogen in women with an intact uterus is associated with an increased risk of endometrial cancer. The addition of a progestin to estrogen therapy may decrease the risk of endometrial hyperplasia, a precursor to endometrial cancer. Adequate diagnostic measures, including endometrial sampling if indicated, should be performed to rule out malignancy in postmenopausal women with undiagnosed abnormal vaginal bleeding. Estrogens may exacerbate endometriosis. Malignant transformation of residual endometrial implants has been reported posthysterectomy with unopposed estrogen therapy. Consider adding a progestin in women with residual endometriosis posthysterectomy.

• Ovarian cancer: Postmenopausal estrogen therapy and combined estrogen/progesterone therapy may increase the risk of ovarian cancer; however, the absolute risk to an individual woman is small. Although results from various studies are not consistent, risk does not appear to be significantly associated with the duration, route, or dose of therapy. In one study, the risk decreased after 2 years following discontinuation of therapy (Morch, 2009). Although the risk of ovarian cancer is rare, women who are at an increased risk (eg, family history) should be counseled about the association (NAMS, 2012).

• Retinal vascular thrombosis: Discontinue pending examination in cases of sudden partial or complete vision loss, sudden onset of proptosis, diplopia, or migraine; discontinue permanently if papilledema or retinal vascular lesions are observed on examination.

• Cardiovascular disease: [US Boxed Warning]: Estrogens with or without progestin should not be used to prevent cardiovascular disease. Using data from the Women’s Health Initiative (WHI) studies, an increased risk of deep vein thrombosis (DVT) and stroke has been reported with CE and an increased risk of DVT, stroke, pulmonary emboli (PE) and myocardial infarction (MI) has been reported with CE with MPA in postmenopausal women. Additional risk factors include diabetes mellitus, hypercholesterolemia, hypertension, SLE, obesity, tobacco use, and/or history of venous thromboembolism (VTE). Risk factors should be managed appropriately; discontinue use if adverse cardiovascular events occur or are suspected.

• Depression: Use with caution in patients with a history of depression.

• Diseases exacerbated by fluid retention: Use with caution in patients with diseases which may be exacerbated by fluid retention, including asthma, epilepsy, migraine, diabetes, or renal dysfunction.

• Pediatric: Not for use prior to menarche.

• Surgical patients: Whenever possible, progestins in combination with estrogens should be discontinued at least 4 to 6 weeks prior to and for 2 weeks following elective surgery associated with an increased risk of thromboembolism or during periods of prolonged immobilization.

Dosage form specific issues:

• Benzyl alcohol and derivatives: Some dosage forms may contain benzyl alcohol; large amounts of benzyl alcohol (?99 mg/kg/day) have been associated with a potentially fatal toxicity (“gasping syndrome”) in neonates; the “gasping syndrome” consists of metabolic acidosis, respiratory distress, gasping respirations, CNS dysfunction (including convulsions, intracranial hemorrhage), hypotension, and cardiovascular collapse (AAP ["Inactive" 1997]; CDC, 1982); some data suggests that benzoate displaces bilirubin from protein binding sites (Ahlfors, 2001); avoid or use dosage forms containing benzyl alcohol with caution in neonates. See manufacturer’s labeling.

• Palm oil: Some products may contain palm oil.

• Peanut oil: Some products may contain peanut oil.

• Sesame oil: Some products may contain sesame oil.

• Hazardous agent: Use appropriate precautions for handling and disposal (NIOSH, 2014 [group 2]) .

• Risks vs benefits: [US Boxed Warning]: Estrogens with or without progestin should be used for the shortest duration possible at the lowest effective dose consistent with treatment goals. Before prescribing estrogen therapy to postmenopausal women, the risks and benefits must be weighed for each patient. Women should be informed of these risks and benefits, as well as possible effects of progestin when added to estrogen therapy. Patients should be reevaluated as clinically appropriate to determine if treatment is still necessary. Available data related to treatment risks are from Women’s Health Initiative (WHI) studies, which evaluated oral CE 0.625 mg with or without MPA 2.5 mg relative to placebo in postmenopausal women. Other combinations and dosage forms of estrogens and progestins were not studied. Outcomes reported from clinical trials using CE with or without MPA should be assumed to be similar for other doses and other dosage forms of estrogens and progestins until comparable data becomes available.

Monitoring Parameters

Routine physical examination that includes blood pressure and Papanicolaou smear, breast exam, mammogram. Adequate diagnostic measures, including endometrial sampling, if indicated, should be performed to rule out malignancy in all cases of undiagnosed abnormal vaginal bleeding. Signs and symptoms of thromboembolic disorders, vision changes

Pregnancy Risk Factor

Pregnancy Considerations

The oral capsules are contraindicated for use during pregnancy.

Adverse events were not observed following oral administration in animal reproduction studies. Adverse events following maternal use in pregnancy (eg, hypospadias, congenital heart disease, cleft lip/palate) have been noted in postmarketing data, however a causal relationship has not been clearly established. Use of vaginal progesterone may be considered to decrease the risk of recurrent spontaneous preterm birth in women with a singleton pregnancy and prior spontaneous preterm singleton birth (therapy may begin at 16 to 24 weeks, regardless of cervical length). It may also be used to prevent spontaneous preterm birth in women with a singleton pregnancy who have a cervix <20 mm before or at 24 weeks gestation. Use is not recommended as an intervention for women with multiple gestations (ACOG, 2012). The vaginal gel and insert are indicated for use in ART.

Patient Education

• Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)

• Patient may experience fatigue, insomnia, more hungry, constipation, hair loss, abdominal pain, cramps, bloating, diarrhea, enlarged breasts, muscle pain, back pain, loss of strength and energy, decreased libido, or injection site irritation. Have patient report immediately to prescriber signs of severe cerebrovascular disease (change in strength on one side is greater than the other, trouble speaking or thinking, change in balance, or change in eyesight), signs of DVT (edema, warmth, numbness, change in color, or pain in the extremities), angina, shortness of breath, coughing up blood, abnormal gait, severe headache, severe nausea, vomiting, severe dizziness, passing out, bulging eyes, vision changes, lump in breast, breast soreness or pain, nipple discharge, vaginitis, vaginal bleeding, pain with urination, polyuria, depression, mood changes, memory impairment, seizures, swelling of hands or feet, signs of liver problems (dark urine, feeling tired, lack of appetite, nausea, abdominal pain, light-colored stools, vomiting, or yellow skin or eyes), or pelvic pain (HCAHPS).

• Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.

Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for healthcare professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience and judgment in diagnosing, treating and advising patients.

Amazonsmile Org Central Customers Shop, Amazolon

Get Started

How do I register and receive donations for my charitable organization?

Registering your organization is easy. In order to register and receive donations, you must be an official representative of an eligible organization, and then follow these easy steps:

Search for your charitable organization by name or EIN number and then select the organization you represent. Be sure to confirm you are selecting the correct organization, as many charitable organizations have similar names.

Create an organization administrator account and accept the AmazonSmile Participation Agreement on behalf of your organization.

Verify your email address (we recommend that you use an email address that is associated with your charitable organization).

Submit your organization’s bank account information.

Upload a copy of a voided check or bank statement to verify your organization’s bank account information.

What is an organization administrator?

An organization administrator is an official representative of an organization that has authority to access and manage AmazonSmile program information on behalf of their charitable organization.

Why do you need an email address for my charitable organization?

We require a valid email address so that we can communicate important program information to each registered organization. From time to time we will send emails with information about your organization’s donation amounts and information about AmazonSmile program promotions.

Can you mail our organization a donation check instead of sending an electronic funds transfer?

We do not mail donation checks due to the expense of check processing and fulfillment. We distribute donations using electronic transfer to reduce operational expenses so we can donate 100% of the funds to eligible charitable organizations.

Will customers still be able to select my charitable organization if I don’t register?

Yes. As long as your organization is listed by GuideStar and meets our eligibility criteria, customers will be able to select your organization. However, no donations will be made to your organization until you complete your free registration. See "What happens if we do not register. " under Receive Donations for more information on how donations are processed for organizations that do not register and provide bank account information.

What happens if another person has already registered my charitable organization and they were not authorized to do so?

If your organization has been registered by an unauthorized person please contact us .

About AmazonSmile

What is AmazonSmile?

AmazonSmile is a website operated by Amazon that lets customers enjoy the same wide selection of products, low prices, and convenient shopping features as on Amazon. com. The difference is that when customers shop on AmazonSmile (smile. amazon. com ), the AmazonSmile Foundation will donate 0.5% of the price of eligible purchases to the charitable organizations selected by customers.

What are the eligibility requirements for charitable organizations to participate?

Organizations must be registered and in good standing with the IRS as a 501(c)(3) to be eligible to participate. Organizations must be public charitable organizations (not private foundations) and may not be supporting organizations, unless identified specifically as a Type I, Type II, or functionally integrated Type III supporting organization. Eligible charitable organizations must also be located in one of the 50 U. S. states or the District of Columbia. Organizations that engage in, support, encourage, or promote intolerance, hate, terrorism, violence, money laundering, or other illegal activities are not eligible to participate. Amazon relies on the US Office of Foreign Assets Control and the Southern Poverty Law Center to determine which registered charities fall into these groups. Charitable organizations must also adhere to the AmazonSmile Participation Agreement to maintain eligibility. Charitable organizations may choose not to participate in AmazonSmile at any time. Although we aim to include only charitable organizations that are in good standing and do not engage in any of the activities described above, we cannot guarantee the good standing and/or conduct of any charitable organization. For complete details, see the AmazonSmile Participation Agreement .

How does AmazonSmile work?

When first visiting AmazonSmile, customers are prompted to select a charitable organization from almost one million eligible organizations. In order to browse or shop at AmazonSmile, customers must first select a charitable organization. For eligible purchases at AmazonSmile, the AmazonSmile Foundation will donate 0.5% of the purchase price to the customer’s selected charitable organization.

Is there any cost to charitable organizations or to customers?

No. There is no cost to charitable organizations or to AmazonSmile customers. The shopping experience is identical to Amazon. com with the added benefit that the AmazonSmile Foundation will donate to the charitable organizations selected by customers.

Do you charge any administrative fees or take any deduction from the donation amount?

No. Charities must register to receive donations and have a valid bank account to which we can route donations, but there is no charge to participate and we do not deduct any fees from the donation amount.

Can charitable organizations outside the U. S. participate?

No. Eligible charitable organizations must be qualified under Section 501(c)(3) and located in one of the 50 U. S. States or the District of Columbia.

What are spotlight charities?

From time to time we may highlight one or more charitable organizations from the total list of eligible organizations. We do this to make it easier for customers to choose an organization to support from the almost one million available, but we do not endorse any particular organization or the causes they support. To apply for consideration as a spotlight charity, please submit a spotlight charity application. Note that you must first register your charitable organization at org. amazon. com. Sign in to org. amazon. com, then click the Help link at the top of the page, then under General Program Information, select the Spotlight Charities link to access the application form.

What is the AmazonSmile Foundation?

The AmazonSmile Foundation is a 501(c)(3) private foundation created by Amazon to administer the AmazonSmile program. All donation amounts generated by the AmazonSmile program are remitted to the AmazonSmile Foundation. In turn, the AmazonSmile Foundation donates those amounts to the charitable organizations selected by our customers. Amazon pays all expenses of the AmazonSmile Foundation; they are not deducted from the donation amounts generated by purchases on AmazonSmile.

May customers make direct donations to charitable organizations through the AmazonSmile program?

Not at this time. The only way for customers to support their selected charitable organization is by shopping at smile. amazon. com.

Does the AmazonSmile Foundation take any portion of donations to fund its operations?

No. Amazon funds the operations of the AmazonSmile Foundation.

How do I contact AmazonSmile?

To submit a question to the org. amazon. com support team, use this contact us form.

If I do not want my organization to participate in the AmazonSmile program, what do I do?

If you do not want your organization to participate in the AmazonSmile program please contact us and request that your organization be removed from the program.

Where did you get my organization's information?

Amazon uses GuideStar as the authoritative source for publicly available charitable organization data. To modify your organization’s address or mission statement, update your Nonprofit Profile at GuideStar. Please contact us to request an update to your organization’s name.

How can we change the AmazonSmile organization administrator to another person?

Sign in to Org Central and select Settings at the top of the page. Click on the "Remove me as administrator" button. Then, a new administrator will need to register the organization and resubmit bank account information at org. amazon. com.

If your administrator is no longer with the company or you believe your account was claimed by someone outside your organization, please contact us and include a request in your message to remove the current administrator. Also please provide contact information for the new organization administrator.

How do I change my account information such as email address and password?

Sign in to Org Central and select Settings and then Edit Account Information or Contact Information. Note that if this same email address is associated with other Amazon. com accounts such as the account you purchase products with, the name, email address, or password will also be changed for your other Amazon. com accounts.

How do I update the bank account information for our electronic transfer?

Log into org. amazon. com and select Settings and then click on the Edit button next to Deposit Method.

How can I update my organization’s name, address, or mission statement?

To modify your organization’s address or mission statement, update your Nonprofit Profile at GuideStar. Please contact us to request an update to your organization’s name.

What do I do if my organization’s administrator is no longer with our nonprofit and we need to change the administrator?

If your org. amazon. com account is registered to an administrator who is no longer with your organization, please contact us and include a request in your message to remove the current administrator. Also please provide contact information for the new organization administrator.

Receive Donations

How does my charity receive the donations?

Each quarter, the AmazonSmile Foundation makes donations to eligible charitable organizations by electronic funds transfer. Donations will be transferred approximately 45 days after the end of each calendar quarter. To account for product returns, a portion of the quarterly donations will be withheld until the next donation cycle, subject to any reduction due to returns from prior quarters. See the AmazonSmile Participation Agreement for more details.

What happens if we do not register our charitable organization and provide a bank account for an electronic transfer?

If you have not registered and have donations allocated to your organization, we will attempt to contact you with instructions on how to register. If you do not register your charitable organization, including providing accurate bank account information for an electronic transfer, the AmazonSmile Foundation will still track and store donations earned in each calendar quarter. Once you’ve registered your charitable organization, your organization will be eligible to receive in the next donation cycle all donation amounts that were previously allocated to your organization and were not subject to reallocation under the Participation Agreement. Please note that donations that have been allocated to an unregistered charitable organization from customers that made their first supporting purchase more than eight full quarters ago and have not been distributed will be reallocated to other registered charitable organizations.

How much of the customers’ purchase price does Amazon donate?

The AmazonSmile Foundation will donate 0.5% of the purchase price from customers’ eligible AmazonSmile purchases to the charitable organizations they select. The purchase price for each item is the sale price, excluding shipping, handling, and gift-wrapping fees, taxes, and service charges, and less any rebates, returns, and bad debt. Certain items are not eligible for and will not result in donations.

What purchases are eligible for donations?

Tens of millions of products on AmazonSmile are eligible for donations. You will see eligible products marked “Eligible for AmazonSmile donation” on their product detail pages. Recurring Subscribe-and-Save purchases and subscription renewals are not currently eligible. For more information, see Qualifying Purchases in the AmazonSmile Participation Agreement .

In order to receive a donation disbursement, what is the minimum amount my organization needs to have accrued from customer purchases?

The minimum amount a charitable organization must accrue to receive a quarterly donation is $5.00. If the total donation amount due to your organization, based on the purchases by all customers who selected your charitable organization, is less than $5.00 as of the end of a given calendar quarter, the AmazonSmile Foundation will hold the donation amounts and add them to donation amounts allocated to your organization in subsequent calendar quarters. However, if you have an accrued donation that remains below $5.00 for four consecutive quarters, the AmazonSmile Foundation will disburse accrued donation amounts to you in the donation cycle following the fourth quarter, even if the donation amount is less than $5.00. For complete details, see the AmazonSmile Participation Agreement .

Can I view the amount of donations my charitable organization has received?

We currently do not provide reports that enable viewing of donations received.

I registered but didn't receive a donation. What happened?

If you registered, but did not receive a donation disbursement, please ensure that you have added the correct bank account information for your organization to your Org Central account. Also, you will not receive a donation disbursement if your organization’s earnings are below the minimum donation amount of $5.00. Note that donations accrued during each calendar quarter are disbursed approximately 45 days after the end of that calendar quarter. Even if your organization does not accrue at least $5.00 in donations, the AmazonSmile Foundation will make a donation at least once per year. If you have questions, please contact us .

Spread the Word

How do we spread the word about AmazonSmile to our supporters?

Visit org. amazon. com to access tools to help you spread the word to your supporters. Sign in to your organization’s org. amazon. com account and click on “Marketing Tools” to obtain a link to a customized AmazonSmile landing page for your organization that you may use in email newsletters, on your website, or in social media posts. Also, access a downloadable website banner and social sharing widgets to reach your Facebook and Twitter followers.

Are there any restrictions regarding the promotion of the AmazonSmile program by charitable organizations?

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Irtan, Irtan

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Iran , a mountainous, arid, ethnically diverse country of southwestern Asia. Much of Iran consists of a central desert plateau. which is ringed on all sides by lofty mountain ranges that afford access to the interior through high passes. Most of the population lives on the edges of this forbidding, waterless waste. The capital is Tehran. a sprawling, jumbled metropolis at the southern foot of the Elburz Mountains. Famed for its handsome architecture and verdant gardens, the city fell somewhat into disrepair in the decades following the Iranian Revolution of 1978–79. though efforts were later mounted to preserve historic buildings and expand the city’s network of parks. As with Tehran, cities such as E?fahan and Shiraz combine modern buildings with important landmarks from the past and serve as major centres of education, culture, and commerce.

Encyclop?dia Britannica, Inc.

The heart of the storied Persian empire of antiquity, Iran has long played an important role in the region as an imperial power and later—because of its strategic position and abundant natural resources, especially petroleum—as a factor in colonial and superpower rivalries. The country’s roots as a distinctive culture and society date to the Achaemenian period, which began in 550 bce. From that time the region that is now Iran—traditionally known as Persia—has been influenced by waves of indigenous and foreign conquerors and immigrants, including the Hellenistic Seleucids and native Parthians and Sasanids. Persia’s conquest by the Muslim Arabs in the 7th century ce was to leave the most-lasting influence, however, as Iranian culture was all but completely subsumed under that of its conquerors.

Encyclop?dia Britannica, Inc.

An Iranian cultural renaissance in the late 8th century led to a reawakening of Persian literary culture, though the Persian language was now highly Arabized and in Arabic script, and native Persian Islamic dynasties began to appear with the rise of the ?ahirids in the early 9th century. The region fell under the sway of successive waves of Persian, Turkish, and Mongol conquerors until the rise of the ?afavids, who introduced Ithna ?Ashari Shi?ism as the official creed, in the early 16th century. Over the following centuries, with the state-fostered rise of a Persian-based Shi?ite clergy, a synthesis was formed between Persian culture and Shi?ite Islam that marked each indelibly with the tincture of the other.

With the fall of the ?afavids in 1736, rule passed into the hands of several short-lived dynasties leading to the rise of the Qajar line in 1796. Qajar rule was marked by the growing influence of the European powers in Iran’s internal affairs, with its attendant economic and political difficulties, and by the growing power of the Shi?ite clergy in social and political issues.

The country’s difficulties led to the ascent in 1925 of the Pahlavi line, whose ill-planned efforts to modernize Iran led to widespread dissatisfaction and the dynasty’s subsequent overthrow in the revolution of 1979. This revolution brought a regime to power that uniquely combined elements of a parliamentary democracy with an Islamic theocracy run by the country’s clergy. The world’s sole Shi?ite state, Iran found itself almost immediately embroiled in a long-term war with neighbouring Iraq that left it economically and socially drained, and the Islamic republic’s alleged support for international terrorism left the country ostracized from the global community. Reformist elements rose within the government during the last decade of the 20th century, opposed both to the ongoing rule of the clergy and to Iran’s continued political and economic isolation from the international community.

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MLA style: "Iran". Encyclopædia Britannica. Encyclopædia Britannica Online. Encyclopædia Britannica Inc. 2016. Web. 19 сен. 2016 < https://www. britannica. com/place/Iran >.

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Buburone, Buburone

Buburone

A nonsteroidal anti-inflammatory agent with analgesic properties used in the therapy of rheumatism and arthritis.

Pharmacology of Buburone

Buburone is a nonsteroidal antiinflammatory drug (NSAID) with analgesic and antipyretic properties. Buburone has pharmacologic actions similar to those of other prototypical NSAIAs, that is thought to be associated with the inhibition of prostaglandin synthesis. Buburone is used to treat rheumatoid arthritis. osteoarthritis. dysmenorrhea, and to alleviate moderate pain.

Buburone for patients

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and inflammation, reduce fever, and treat osteoarthritis. rheumatoid arthritis. and menstrual cramps. Inform your physician if you are pregnant or nursing. Ibuprofen should not be taken during the last three months of pregnancy. Inform your physician if you use alcohol chronically. Ibuprofen should not be taken with aspirin products. This medication should be taken with food, milk or antacids if stomach upset occurs. Ibuprofen may cause dizziness and drowsiness; use caution while driving or operating hazardous machinery. Ibuprofen may cause increased sensitivity to sunlight. Use sunscreens and wear protective clothing until degree of sensitivity is determined. Notify your physician if you develop stomach pain, bloody vomit, bloody or black tarry stools, cloudy urine. trouble breathing, rash or hives.

Buburone Interactions

Coumarin-Type Anticoagulants: Several short-term controlled studies failed to wshow that ibuprofen significantly affected prothrombin times or a variety of other clotting factors when administered to individuals on coumarin-type anticoagulants. However, because bleeding has been reported when ibuprofen and other nonsteroidal anti-inflammatory agents have been administered to patients on coumarin-type anticoagulants, the physician should be cautious when administering ibuprofen to patients on anticoagulants.

Aspirin: Animal studies wshow that aspirin given with nonsteroidal anti-inflammatory agents, including ibuprofen, yields a net decrease in anti-inflammatory activity with lowered blood levels of the non-aspirin drug. Single dose bioavailability studies in normal volunteers have failed to wshow an effect of aspirin on ibuprofen blood levels. Correlative clinical studies have not been performed.

Methotrexate: Ibuprofen, as well as other nonsteroidal anti-inflammatory drugs, probably reduces the tubular secretion of methotrexate based on in vitro studies in rabbit kidney slices. This may indicate that ibuprofen could enhance the toxicity of methotrexate. Caution should be used if ibuprofen is administered concomitantly with methotrexate.

H-2 Antagonists: In studies with human volunteers, co-administration of cimetidine or ranitidine with ibuprofen had no substantive effect on ibuprofen serum concentrations.

Furosemide: Clinical studies, as well as random observations, have shown that ibuprofen can reduce the natriuretic effect of furosemide and thiazides in some patients. This response has been attributed to inhibition of renal prostaglandin synthesis. During concomitant therapy with ibuprofen, the patient should be observed closely for signs of renal failure, as well as to assure diuretic efficacy.

Lithium: Ibuprofen produced an elevation of plasma lithium levels and a reduction in renal lithium clearance in a study of eleven normal volunteers. The mean minimum lithium concentration increased 15% and the renal clearance of lithium was decreased by 19% during this period of concomitant drug administration.

This effect has been attributed to inhibition of renal prostaglandin synthesis by ibuprofen. Thus, when ibuprofen and lithium are administered concurrently, subjects should be observed carefully for signs of lithium toxicity. (Read circulars for lithium preparation before use of such concurrent therapy).

Buburone Contraindications

Ibuprofen tablets or ibuprofen children's suspension should not be used in patients who have previously exhibited hypersensitivity to the drug, or in individuals with the syndrome of nasal polyps, angioedema, and bronchospastic reactivity to aspirin or other nonsteroidal anti-inflammatory agents. Anaphylactoid reactions have occurred in such patients.

Additional information about Buburone

Buburone Indication: For the treatment of pain (muscular and rheumatic), sprains, strains, backache and neuralgia Mechanism Of Action: The exact mechanisms of action of Buburone is unknown. Its antiinflammatory effects are believed to be due to inhibition of both cylooxygenase-1 (COX-1) and cylooxygenase-2 (COX-2) which leads to the inhibition of prostaglandin synthesis, and results in the inhibition of prostaglandin synthesis. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation. Drug Interactions: Acebutolol Risk of inhibition of renal prostaglandins Atenolol Risk of inhibition of renal prostaglandins Betaxolol Risk of inhibition of renal prostaglandins Bevantolol Risk of inhibition of renal prostaglandins Bisoprolol Risk of inhibition of renal prostaglandins Carteolol Risk of inhibition of renal prostaglandins Carvedilol Risk of inhibition of renal prostaglandins Esmolol Risk of inhibition of renal prostaglandins Labetalol Risk of inhibition of renal prostaglandins Nadolol Risk of inhibition of renal prostaglandins Metoprolol Risk of inhibition of renal prostaglandins Oxprenolol Risk of inhibition of renal prostaglandins Penbutolol Risk of inhibition of renal prostaglandins Pindolol Risk of inhibition of renal prostaglandins Practolol Risk of inhibition of renal prostaglandins Propranolol Risk of inhibition of renal prostaglandins Sotalol Risk of inhibition of renal prostaglandins Timolol Risk of inhibition of renal prostaglandins Warfarin The NSAID increases the anticoagulant effect Acenocoumarol The NSAID increases the anticoagulant effect Dicumarol The NSAID increases the anticoagulant effect Anisindione The NSAID increases the anticoagulant effect Ethacrynic acid The NSAID decreases the diuretic and antihypertensive effect of the loop diuretic Furosemide The NSAID decreases the diuretic and antihypertensive effect of the loop diuretic Torasemide The NSAID decreases the diuretic and antihypertensive effect of the loop diuretic Bumetanide The NSAID decreases the diuretic and antihypertensive effect of the loop diuretic Aspirin Buburone reduces ASA cardioprotective effects Methotrexate The NSAID increases the effect and toxicity of methotrexate Alendronate Increased risk of gastric toxicity Cyclosporine Monitor for nephrotoxicity Lithium The NSAID increases serum levels of lithium Food Interactions: Avoid alcohol. Take with food to reduce irritation. Generic Name: Ibuprofen Synonyms: P-Isobutylhydratropic Acid; Para-Isobutylhydratropic Acid; Ibuprophen Drug Category: Analgesics; Cyclooxygenase Inhibitors; Anti-inflammatory Agents; Nonsteroidal Antiinflammatory Agents (NSAIDs) Drug Type: Small Molecule; Approved Other Brand Names containing Ibuprofen: Actiprofen; Adran; Advil; Advil Liqui-Gels; Amersol; Amibufen; Anco; Andran; Anflagen; Apo-Ibuprofen; Apsifen; Apsifen-F; Artril 300; Bluton; Brufanic; Brufen; Brufort; Buburone; Butylenin; Cap-Profen; Children's Advil; Children's Elixsure; Children's Ibuprofen; Children's Motrin; Codral; Dolgin; Dolgirid; Dolgit; Dolo-Dolgit; Dolocyl; Ebufac; Emodin; Epobron; Femadon; Fenbid Spansule; Haltran; Ibu; Ibu-Attritin; Ibu-Slo; Ibu-Tab; Ibu-Tab 200; Ibufen; Ibumetin; Ibuprin; Ibuprocin; Ibuprohm; Ibutid; Ifen; Inabrin; Inoven; Junior Strength Advil; Junior Strength Ibuprofen; Junior Strength Motrin; Lamidon; Lebrufen; Lidifen; Liptan; Medipren; Midol; Midol 200; Motrin; Mynosedin; Napacetin; Nobfelon; Nobfen; Nobgen; Novogent N; Novoprofen; Nuprin; Nurofen; Pantrop; Paxofen; Pedia-Profen; Pediaprofen; Pediatric Advil; Profen; Rafen; Rebugen; Roidenin; Rufen; Seclodin; Suspren; Tab-Profen; Tabalon; Trendar; Urem; Absorption: rapidly absorbed Toxicity (Overdose): Abdominal pain, breathing difficulties, coma, drowsiness, headache. irregular heartbeat, kidney failure, low blood pressure, nausea, ringing in the ears, seizures, sluggishness, vomiting; LD 50 =1255mg/kg(orally in mice) Protein Binding: 99% Biotransformation: Hepatic Half Life: 1.8-2.0 hours Dosage Forms of Buburone: Tablet Oral Tablet, chewable Oral Suspension Oral Capsule Oral Chemical IUPAC Name: 2-[4-(2-methylpropyl)phenyl]propanoic acid Chemical Formula: C13H18O2 Ibuprofen on Wikipedia: http://en. wikipedia. org/wiki/Ibuprofen Organisms Affected: Humans and other mammals

Standard Reference Data Program

Ibuprofen

Formula : C 13 H 18 O 2

Molecular weight : 206.2808

IUPAC Standard InChI: InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)

IUPAC Standard InChIKey: HEFNNWSXXWATRW-UHFFFAOYSA-N

CAS Registry Number: 15687-27-1

Chemical structure: View the 3d structure.

Other names: Benzeneacetic acid, α-methyl-4-(2-methylpropyl)-; 4-Isobutyl-α-methylphenylacetic acid; α-(p-isobutylphenyl)propionic acid; α-(4-Isobutylphenyl)propionic acid; (.+/-.)-p-Isobutylhydratropic acid; (.+/-.)-2-(p-Isobutylphenyl)propionic acid; p-Isobutylhydratropic acid; Acide (isobutyl-4 phenyl)-2 propionique; Andran; Brufen; Buburone; Dolgit; Ebufac; Hydratropic acid, p-isobutyl-; Ibu-slo; Ibuprocin; IP-82; Liptan; Motrin; Nobfelon; Pantrop; R. D. 13621; Rebugen; U-18,573; 2-(p-Isobutylphenyl)propionic acid; 2-(4-Isobutylphenyl)propanoic acid; 4-Isobutylhydratropic acid; Adran; Anflagen; Artril 300; Bluton; Brufanic; Butylenin; Dolgin; Emodin; Epobron; Ibufen; Lamidon; Mynosedin; Napacetin; Nobfen; Nobgen; Nurofen; Roidenin; Benzeneacetic acid, α-methyl-4-(2-methylpropyl), (.+/-.)-; Advil; Haltran; Medipren; Midol 200; Nuprin; PediaProfen; Trendar; α-2-(p-Isobutylphenyl)propionic acid; Propanoic acid, 2-(4-isobutylphenyl); RD 13621; 4-Isobutylphenyl)-α-methylacetic acid; (RS)-Ibuprofen; p-Isobutyl-2-phenylpropionic acid; Burana; Butacortelone; Carol; Cobo; Optifen; Ostofen; Panafen; Proartinal; Proflex; Quadrax; Uprofen; Dibufen; Ibupril; Apsifen; α-Methyl-4-(2-methylpropyl)benzeneacetic acid; (±) α-methyl-4-(isobutyl)phenylacetic acid (ibuprofen)

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Standard Reference Data Program

Standard Reference Data Program

Ibuprofen

Formula : C 13 H 18 O 2

Molecular weight : 206.2808

IUPAC Standard InChI: InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)

IUPAC Standard InChIKey: HEFNNWSXXWATRW-UHFFFAOYSA-N

CAS Registry Number: 15687-27-1

Chemical structure: View the 3d structure.

Other names: Benzeneacetic acid, α-methyl-4-(2-methylpropyl)-; 4-Isobutyl-α-methylphenylacetic acid; α-(p-isobutylphenyl)propionic acid; α-(4-Isobutylphenyl)propionic acid; (.+/-.)-p-Isobutylhydratropic acid; (.+/-.)-2-(p-Isobutylphenyl)propionic acid; p-Isobutylhydratropic acid; Acide (isobutyl-4 phenyl)-2 propionique; Andran; Brufen; Buburone; Dolgit; Ebufac; Hydratropic acid, p-isobutyl-; Ibu-slo; Ibuprocin; IP-82; Liptan; Motrin; Nobfelon; Pantrop; R. D. 13621; Rebugen; U-18,573; 2-(p-Isobutylphenyl)propionic acid; 2-(4-Isobutylphenyl)propanoic acid; 4-Isobutylhydratropic acid; Adran; Anflagen; Artril 300; Bluton; Brufanic; Butylenin; Dolgin; Emodin; Epobron; Ibufen; Lamidon; Mynosedin; Napacetin; Nobfen; Nobgen; Nurofen; Roidenin; Benzeneacetic acid, α-methyl-4-(2-methylpropyl), (.+/-.)-; Advil; Haltran; Medipren; Midol 200; Nuprin; PediaProfen; Trendar; α-2-(p-Isobutylphenyl)propionic acid; Propanoic acid, 2-(4-isobutylphenyl); RD 13621; 4-Isobutylphenyl)-α-methylacetic acid; (RS)-Ibuprofen; p-Isobutyl-2-phenylpropionic acid; Burana; Butacortelone; Carol; Cobo; Optifen; Ostofen; Panafen; Proartinal; Proflex; Quadrax; Uprofen; Dibufen; Ibupril; Apsifen; α-Methyl-4-(2-methylpropyl)benzeneacetic acid; (±) α-methyl-4-(isobutyl)phenylacetic acid (ibuprofen)

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Cherepashki-Nindzya (2014), Mutan

Teenage Mutant Ninja Turtles (2014)

Trivia

Danny Woodburn was disappointed that he would only motion-capture Splinter and not get to provide his voice. However, he would get to voice Splinter in the video game Teenage Mutant Ninja Turtles (2014).

Quotes

Splinter . You are extraordinary, my sons. Unlike anything the world has ever seen. Bowed in greatness, destined to protect the people of New York! A dark force is growing: a criminal organization known as the Foot Clan, so named because they step over the.

Goofs

(at around 26 mins) During one of April's video tape reviews one of the turtles' tanks is labeled "Michaelangelo" which is incorrectly spelled. It should be "Michelangelo".

Storyline

Synopsis (WARNING: Spoilers)

Pantoprazol Medlineplus Medicinas, Segregam

Pantoprazol

?Para cuales condiciones o enfermedades se prescribe este medicamento?

El pantoprazol se usa para tratar la enfermedad de reflujo gastroesofagico (gastroesophageal reflux disease, GERD), una condicion en la que el flujo en direccion opuesta del acido del estomago causa acidez y posibles lesiones al esofago (el tubo entre la garganta y el estomago). El pantoprazol se usa para tratar los sintomas de GERD, para permitir que el esofago sane y para prevenir dano futuro al esofago. Tambien se usa para tratar condiciones en las que el estomago produce demasiado acido, como el Sindrome de Zollinger-Ellison. El pantoprazol se encuentra en una clase de medicamentos llamados inhibidores de la bomba de protones. Funciona disminuyendo la cantidad de acido que se produce en el estomago.

?Como se debe usar este medicamento?

El pantoprazol viene en una tableta de liberacion retardada (libera el medicamento en el intestino para evitar que los acidos del estomago desintegren el medicamento) y como suspension oral de liberacion retardada (un liquido que libera el medicamento en el intestino para evitar que los acidos del estomago desintegren el medicamento) para tomar por via oral. Los paquetes de granulos de liberacion retardada para la suspension oral se deben mezclar con jugo de manzana o pure de manzana y tomarlos por via oral o administrarlos mediante una sonda de alimentacion. Las tabletas de liberacion retardada usualmente se toman con o sin alimentos, una o dos veces al dia. La suspension oral usualmente se toma 30 minutos antes de una comida, una o dos veces al dia. Tome el pantoprazol aproximadamente a la misma hora todos los dias. Siga atentamente las instrucciones que se encuentran en la etiqueta de su receta medica y pida a su medico o farmaceutico que le explique cualquier parte que no comprenda. Tome pantoprazol exactamente como se indica. No tome mas ni menos cantidad del medicamento ni lo tome con mas frecuencia ni lo tome por un periodo de tiempo mayor al que indica la receta de su medico.

Trague los comprimidos enteros; no los parta, mastique ni triture. Si su medico le receto la tableta de 40 mg y es demasiado grande para tragarla, pidale a su medico que le recete dos tabletas de 20 mg en su lugar.

Para tomar los granulos para la suspension oral, abra el paquete y deje caer los granulos en una cucharada de pure de manzana o en un vaso que contenga una cucharada de jugo de manzana. No mezcle los granulos con agua, otros liquidos u otros alimentos. Use todos los granulos del paquete; no divida los granulos en dosis mas pequenas. Si deja caer los granulos en jugo de manzana, revuelva la mezcla durante 5 segundos. Trague la mezcla de pure de manzana o jugo de manzana y medicamento de inmediato (en un plazo de 10 minutos) sin masticar ni triturar los granulos. Si dejo caer los granulos en pure de manzana, de varios tragos de agua para que los granulos bajen a su estomago. Si dejo caer los granulos en jugo de manzana, enjuague la taza una vez o dos con jugo de manzana y beba el jugo de manzana de inmediato para asegurarse de tragar cualquier granulo que haya quedado.

Los granulos de pantoprazol mezclados con jugo de manzana se pueden administrar mediante una sonda de alimentacion. Si tiene una sonda de alimentacion, pregunte a su medico como debe tomar el pantoprazol.

Continue tomando pantoprazol incluso si se siente bien. No deje de tomar pantoprazol sin hablar con su medico. Si su condicion no mejora o empeora, llame a su medico.

?Que otro uso se le da a este medicamento?

Este medicamento se puede recetar para otros usos; pida mas informacion a su medico o farmaceutico.

?Cuales son las precauciones especiales que debo seguir?

Antes de tomar pantoprazol,

informe a su medico y farmaceutico si es alergico al pantoprazol, dexlansoprazol (Dexilant), esomeprazol (Nexium, en Vimovo), lansoprazol (Prevacid), omeprazol (Prilosec, en Zegerid), rabeprazol (AcipHex), cualquier otro medicamento, o a alguno de los ingredientes que contienen las tabletas o granulos de pantoprazol. Pida a su farmaceutico una lista de los ingredientes.

Informe a su medico si usted esta tomando rilpivirina (Edurant, en Complera, Odefsey). Su medico probablemente le dira que no tome pantoprazol si usted esta tomando este medicamento.

Informe a su medico y farmaceutico que medicamentos con y sin receta medica, vitaminas, suplementos nutricionales y productos de hierbas esta tomando o tiene planificado tomar. Asegurese de mencionar cualquiera de los siguientes: algunos antibioticos incluyendo ampicilina, anticoagulantes ('diluyentes de la sangre') como warfarina (Coumadin; Jantoven), atazanavir (Reyataz), digoxina (Lanoxin), diureticos ('pildoras que provocan la eliminacion de agua a traves de la orina'), suplementos de hierro, cetoconazol (Nizoral), metotrexato (Trexall) y nelfinavir (Viracept). Es posible que su medico deba cambiar las dosis de sus medicamentos o supervisarle atentamente para saber si sufre efectos secundarios.

Informe a su medico si tiene o ha tenido nivel bajo de magnesio en su sangre o si dio positivo para la bacteria H. pylori .

Informe a su medico si esta embarazada, planea quedar embarazada o esta amamantando. Si queda embarazada mientras toma pantoprazol, llame a su medico.

?Que dieta especial debo seguir mientras tomo este medicamento?

A menos que su medico le indique lo contrario, continue con su dieta normal.

?Que tengo que hacer si me olvido de tomar una dosis?

Tome la dosis que omitio tan pronto como lo recuerde. Sin embargo, si ya es casi la hora de su siguiente dosis, omita la dosis que le falto y continue con su horario regular de dosificacion. No duplique la dosis para compensar una dosis omitida.

?Cuales son los efectos secundarios que podria provocar este medicamento?

El pantoprazol puede ocasionar efectos secundarios. Informe a su medico si cualquiera de estos sintomas es grave o no desaparece:

dolor de cabeza

nausea

vomitos

flatulencia

dolor de articulaciones

estrenimiento

Algunos efectos secundarios pueden ser graves. Si experimenta cualquiera de los sintomas siguientes, llame a su medico inmediatamente, o busque tratamiento medico de emergencia:

ampollas o descamacion de la piel

sarpullido

urticaria

picazon

inflamacion de los ojos, el rostro, los labios, la boca, la garganta o la lengua

dificultad para respirar o tragar

ronquera

ritmo cardiaco fuerte, rapido o irregular

cansancio excesivo

mareos

desvanecimientos

espasmos musculares

temblor incontrolable de una parte del cuerpo

convulsiones

diarrea severa con heces acuosas

dolor de estomago

fiebre

El pantoprazol puede ocasionar otros efectos secundarios. Llame a su medico si tiene algun problema inusual mientras toma este medicamento.

Las personas que toman los inhibidores de la bomba de protones como el pantoprazol pueden tener mas probabilidad de fractura de las munecas, caderas o columna vertebral que las personas que no toman uno de estos medicamentos. El riesgo es mas alto en personas que toman dosis altas de uno de estos medicamentos o que los han tomado por un ano o mas.

Las personas que toman pantoprazol por un largo tiempo pueden desarrollar debilitamiento del recubrimiento del estomago y un bajo nivel de vitamina B12 en la sangre.

Hable con su medico sobre los riesgos de tomar pantoprazol.

Si desarrolla un efecto secundario grave, usted o su doctor puede enviar un informe al programa de divulgacion de efectos adversos 'MedWatch' de la Administracion de Alimentos y Medicamentos (FDA, por su sigla en ingles) en la pagina de Internet (http://www. fda. gov/Safety/MedWatch ) o por telefono al 1-800-332-1088.

?Como debo almacenar o desechar este medicamento?

Mantenga este medicamento en su envase original, cerrado hermeticamente y fuera del alcance de los ninos. Almacenelo a temperatura ambiente y lejos del exceso de calor y humedad (no en el bano).

Los medicamentos que ya no son necesarios se deben desechar de una manera apropiada para asegurarse de que las mascotas, los ninos y otras personas no puedan consumirlos. Sin embargo, no debe desechar estos medicamentos por el inodoro. En su lugar, la mejor manera de deshacerse de sus medicamentos es a traves de un programa de devolucion de medicamentos. Hable con su farmaceutico o pongase en contacto con su departamento de basura/reciclaje local para conocer acerca de los programas de devolucion de medicamentos de su comunidad. Consulte el sitio web de la Administracion de Medicamentos y Alimentos (FDA), (http://goo. gl/c4Rm4p ) para obtener mas informacion de como desechar de forma segura los medicamentos, si no tiene acceso al programa de devolucion de medicamentos.

?Que debo hacer en caso de una sobredosis?

En caso de una sobredosis, llame a la oficina local de control de envenenamiento al 1-800-222-1222. Si la victima esta inconsciente, o no respira, llame inmediatamente al 911.

?Que otra informacion de importancia deberia saber?

Asista a todas las citas con su medico y el laboratorio. Su medico puede ordenar algunas pruebas de laboratorio antes y durante su tratamiento, especialmente si tiene diarrea intensa.

Antes de realizarse alguna prueba de laboratorio, informe al medico y al personal del laboratorio que esta tomando pantoprazol.

No deje que nadie mas tome su medicamento. Haga a su farmaceutico cualquier pregunta que tenga sobre como volver a surtir su receta medica.

Es importante que Ud. mantenga una lista escrita de todas las medicinas que Ud. esta tomando, incluyendo las que recibio con receta medica y las que Ud. compro sin receta, incluyendo vitaminas y suplementos de dieta. Ud. debe tener la lista cada vez que visita su medico o cuando es admitido a un hospital. Tambien es una informacion importante en casos de emergencia.

Marcas comerciales

Documento actualizado - 15/07/2016

American Society of Health-System Pharmacists, Inc. Clausula de Proteccion

AHFS ® Patient Medication Information. © Copyright, 2016. The American Society of Health-System Pharmacists, Inc. 7272 Wisconsin Avenue, Bethesda, Maryland. Todos los derechos reservados. La duplicacion de este documento para su uso comercial, debera ser autorizada por ASHP. Traducido del ingles por HolaDoctor.

Benzamycin (Erythromycin) Side Effects, Interactions, Warning, Dosage & Uses, Benzamycin

DRUG DESCRIPTION

Benzamycin® Pak contains erythromycin [(3R*, 4S*, 5S*, 6R*, 7R*, 9R*, 11R*, 12R*, 13S*, 14R*)-4-[(2,6- dideoxy-3-C-methyl-3-O-methyl-a - L-ribo-hexopyranosyl)-oxy]-14- ethyl-7,12,13-trihydroxy - 3,5,7,9,11,13-hexa-methyl-6-[ [3,4,6-trideoxy-3-(dimethylamino)-b-D - xylo-hexopyranosyl] oxy]oxacyclotetradecane-2,10- dione]. Erythromycin is a macrolide antibiotic produced from a strain of Saccharopolyspora erythraea (formerly Streptomyces erythreus ). It is a base and readily forms salts with acids. Chemically, erythromycin is (C 37 H 67 NO 13 ). It has the following structural formula:

Erythromycin has the molecular weight of 733.94. It is a white crystalline powder and has a solubility of approximately 1 mg/mL in water and is soluble in alcohol at 25°C. Benzamycin (erythromycin) ® Pak also contains benzoyl peroxide for topical use. Benzoyl peroxide is an oxidizing agent demonstrating antibacterial activity. Chemically, benzoyl peroxide is (C 14 H 10 O 4 ). It has the following structural formula:

Benzoyl peroxide has the molecular weight of 242.23. It is a white granular powder and is sparingly soluble in water and alcohol and soluble in acetone. chloroform and ether. Each gram of product, as dispensed, contains 30 mg of erythromycin and 50 mg of benzoyl peroxide in a base of SD Alcohol 40B, purified water, hydroxypropyl cellulose, carbomer 934, sodium hydroxide, dioctyl sodium sulfosuccinate 75%. Each Benzamycin (erythromycin) ® Pak contains 0.8 grams of product.

What are the possible side effects of benzoyl peroxide and erythromycin topical (Benzamycin)?

Serious side effects are not likely to occur. Stop using benzoyl peroxide and erythromycin topical and seek emergency medical attention if you experience an allergic reaction (shortness of breath; closing of the throat; swelling of the lips, face, or tongue; or hives).

You may experience some skin burning, stinging, tingling, itching, redness, dryness, peeling, or irritation while using benzoyl peroxide topical. If these side effects are excessive, apply benzoyl peroxide and erythromycin topical less often.

Side effects other than those listed.

What are the precautions when taking erythromycin (Benzamycin)?

Before using this product, tell your doctor or pharmacist if you are allergic to erythromycin or benzoyl peroxide; or to other macrolide antibiotics (such as azithromycin, clarithromycin); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history.

This medication may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen and wear a hat or other protective clothing when outdoors.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription.

Last reviewed on RxList: 6/10/2008 This monograph has been modified to include the generic and brand name in many instances.

Interactions, Usage, Facts, And Information On Sutril, Sutril

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Sutril (Torsemide)

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DISCLAIMER: MediGuard is not intended to be a substitute for professional medical advice. MediGuard cannot and does not take into consideration every possible interaction or account for individual responses to medicine. Different individuals may respond to medication in different ways. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective, or appropriate for any given patient. Always seek the advice of a qualified health provider with any questions you may have before making any changes to your treatment. The use of the MediGuard site and its content is at your own risk. The MediGuard site and the information contained in it is intended for users in the United States and information in other countries may be different.

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Lamisil - Anti Fungal, Fungorin

Product Description Common use Lamisil is an anti-fungal antibiotic used to treat tinea versicolor, a fungal infection that produces brown, tan, white spots on the trunk of the body or other fungal infections such as athlete's foot, jock itch, and ringworm. Lamisil works by killing sensitive fungi by interfering with the formation of the fungal cell membrane.

Dosage and direction Take it orally with full glass of water. Swallow it without chewing. Usually it taken for 6 to 12 weeks. The recommended dose is different from type of infection: 1. For onychomycosis: Adults and teenagers 250 mg once a day for 6 to 12 weeks. Lamisil is used in children just after doctor's permission. 2. For tinea corporis: Adults and teenagers 250 mg once a day for 2 to 4 weeks. Lamisil is used in children just after doctor's permission. 3. For tinea cruris (ringworm of the groin; jock itch): Adults and teenagers 250 mg once a day for 2 to 4 weeks. Lamisil is used in children just after doctor's permission. 4. For tinea pedis: Adults and teenagers 250 mg once a day for 2 to 6 weeks. Lamisil is used in children just after doctor's permission. Note: this instruction presented here just for review. It's very necessary to consult your doctor before using.

Precautions Before using this medicine, consult your doctor or pharmacist if you have a certain blood disorder or severe liver disease. Don't forget to tell your medical history, especially if it includes lupus. Driving is not recommended while you are taking this medication because it may cause dizziness or less alertness. Drinking alcohol during treatment may cause a fast heartbeat and flushing of the skin. Avoid sun, tanning booths, and sunlamps and use a sunscreen and wear protective clothing when going outdoors. Lamisil should not be used during pregnancy, becoming pregnant or lactating without doctor's advice. Do not use before breast-feeding without doctor's advice.

Contraindications Lamisil is not allowed to people who have problems with their liver or kidneys, hypersensitive to any component of this dug.

Possible side effect They may include an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Also the most possible side effects include: joint pain or swelling, swollen glands, patchy skin color, or a butterfly-shaped skin rash over your cheeks and nose fever, chills, body aches, flu symptoms; changes in your vision; weight loss due to taste changes; scaly, itchy, and flaky skin rash; fever, sore throat, and headache with a severe blistering, peeling, and red skin rash. Less serious include: stomach pain, heartburn, diarrhea; headache; tired feeling; runny or stuffy nose, sore throat, cold symptoms; mild skin rash or itching; unusual or unpleasant taste in your mouth; or decreased taste sensation. If you experience one of them stop using Lamisil and tell your doctor as soon as possible. Also consult your doctor about any side effect that seems unusual.

Drug interaction Lamisil interacts with the following medications: Cyclosporine Metoprolol Nortriptyline Warfarin Also note that interaction between two medications does not always mean that you must stop taking one of them. As usual it affects the effect of drugs, so consult your doctor about its interactions.

Missed dose If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not take double or extra doses. Take your usual dose next day at the same time regularly.

Overdose Symptoms of Lamisil overdose may include: dizziness, stomach pain, nausea, vomiting, skin rash, or urinating more than usual. If you experience one of them call your doctor immediately.

Storage Store at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture, kids and pets. Do not use after expiration date.

Disclaimer We provide only general information about medications that does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Verapamil Medlineplus Drug Information, Verapal

Verapamil

Verapamil is used to treat high blood pressure and to control angina (chest pain). The immediate-release tablets are also used alone or with other medications to prevent and treat irregular heartbeats. Verapamil is in a class of medications called calcium-channel blockers. It works by relaxing the blood vessels so the heart does not have to pump as hard. It also increases the supply of blood and oxygen to the heart and slows electrical activity in the heart to control the heart rate.

High blood pressure is a common condition and when not treated, can cause damage to the brain, heart, blood vessels, kidneys and other parts of the body. Damage to these organs may cause heart disease, a heart attack, heart failure, stroke, kidney failure, loss of vision, and other problems. In addition to taking medication, making lifestyle changes will also help to control your blood pressure. These changes include eating a diet that is low in fat and salt, maintaining a healthy weight, exercising at least 30 minutes most days, not smoking, and using alcohol in moderation.

How should this medicine be used?

Verapamil comes as a tablet, an extended-release (long-acting) tablet, and an extended-release (long-acting) capsule to take by mouth. The regular tablet is usually taken three to four times a day. The extended-release tablets and capsules are usually taken once or twice a day. Take verapamil at around the same time(s) every day. Certain verapamil products should be taken in the morning and others at bedtime. Ask your doctor what the best time is for you to take your medication. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take verapamil exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the extended-release tablets and capsules whole. Do not chew or crush them. Ask your pharmacist if the tablets may be split in half, as the instructions vary by product.

If you can not swallow the extended-release capsules you may carefully open the capsule and sprinkle the entire contents onto a spoonful of applesauce. The applesauce should not be hot, and it should be soft enough to be swallowed without chewing. Swallow the applesauce immediately without chewing, and then drink a glass of cool water to make sure that you have swallowed all of the medicine. Do not store the mixture for future use.

Your doctor will probably start you on a low dose of verapamil and gradually increase your dose.

Verapamil controls arrhythmias, high blood pressure, and angina but does not cure these conditions. Continue to take verapamil even if you feel well. Do not stop taking verapamil without talking to your doctor.

Other uses for this medicine

Verapamil is also sometimes used to treat certain other heart problems. Talk to your doctor about the risks of using this medication for your condition.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking verapamil,

tell your doctor and pharmacist if you are allergic to verapamil, any other medications, or any ingredients in verapamil. Ask your pharmacist for a list of the ingredients.

tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: alpha blockers such as prazosin (Minipress); antifungals such as itraconazole (Onmel, Sporanox) and ketoconazole (Nizoral); aspirin; beta blockers such as atenolol (Tenormin, in Tenoretic), metoprolol (Lopressor, Toprol XL, in Dutoprol), nadolol (Corgard, in Corzide), propranolol (Inderal, Innopran, in Inderide), and timolol (Blocadren, in Timolide); carbamazepine (Carbatrol, Epitol, Equetro, Tegretol); cimetidine (Tagamet); clarithromycin (Biaxin, in Prevpac); cyclosporine (Neoral, Sandimmune); digoxin (Lanoxin); disopyramide (Norpace); diuretics (''water pills''); erythromycin (E. E.S. Eryc, Erythrocin); flecainide; certain HIV protease inhibitors such as indinavir (Crixivan), nelfinavir (Viracept), and ritonavir (Norvir, in Kaletra); quinidine (in Nuedexta); lithium (Lithobid); medications to treat high blood pressure; nefazodone; phenobarbital; pioglitazone (Actos, in Duetact, in Oseni); rifampin (Rifadin, Rimactane); telithromycin (Ketek); and theophylline (Theochron, Theolair, Uniphyl). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with verapamil, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

tell your doctor what herbal products you are taking, especially St. John's wort.

tell your doctor if you have or have ever had narrowing or blockage of your digestive system or any other condition that causes food to move through your digestive system more slowly; heart failure; heart, liver, or kidney disease; muscular dystrophy (inherited disease that causes gradual weakening of muscles); or myasthenia gravis (condition that causes certain muscles to weaken).

tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking verapamil, call your doctor.

if you are having surgery, including dental surgery, tell your doctor or dentist that you are taking verapamil.

talk to your doctor about the safe use of alcoholic beverages during your treatment with verapamil. Verapamil may cause the effects of alcohol to be more severe and longer-lasting.

What special dietary instructions should I follow?

Talk to your doctor about eating grapefruit or drinking grapefruit juice while taking this medicine.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Verapamil may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

constipation

heartburn

dizziness or lightheadedness

headache

Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately or get emergency medical treatment.

swelling of the hands, feet, ankles, or lower legs

difficulty breathing or swallowing

slow heartbeat

fainting

blurred vision

rash

nausea

extreme tiredness

unusual bleeding or bruising

lack of energy

loss of appetite

pain in the upper right part of the stomach

yellowing of the skin or eyes

flu-like symptoms

fever

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www. fda. gov/Safety/MedWatch ) or by phone (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

In case of emergency/overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Symptoms of overdose may include:

dizziness

blurred vision

slow, fast, or irregular heartbeat

seizures

confusion

difficulty breathing or swallowing

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your blood pressure should be checked regularly to determine your response to verapamil. Your doctor may also order certain lab tests to check your body's response to verapamil.

If you are taking certain extended-release tablets (Covera HS), you may notice something that looks like a tablet in your stool. This is just the empty tablet shell, and this does not mean that you did not get your complete dose of medication.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand names

Biofast

BIOFAST BIOTECH ORIGINALITY STUDY CO. LTD has always been devoting its effort on Orthopedics, Foot Cushions, Exercise Care, Skin Care and Household Items, occupying a leading position in the industry for its Biogel technologies, plastic injection molding process, fine sewing process and cushion hot pressing process and so on. At the same time, Biofast provides global customers with great services such as innovation, R&D, production, OEM, ODM, packing and private label. We, Biofast, insist on doing our best on each procedure from product development, production, quality control to after-sales services. On the other hand, we regard promoting the awareness of body and skin care as our main goal and provide customers with the safest, most effective and high-quality products based on our professions and enthusiasm.

New Product

Hiprex Oral Uses, Side Effects, Interactions, Pictures, Warnings - Dosing, Hipres

Hiprex

GENERIC NAME(S): METHENAMINE HIPPURATE

Uses

Methenamine is used to prevent or control returning urinary tract infections caused by certain bacteria. It is not used to treat an active infection. Other antibiotics must be used first to treat and cure the infection. Methenamine is an antibiotic that stops the growth of bacteria in urine. This medication also contains an ingredient that helps to make the urine acidic. When the urine is acidic, methenamine turns into formaldehyde to kill the bacteria.

This antibiotic is effective only against bacterial infections in the urinary tract. It will not work for other types of bacterial infections (such as in the blood ) or for viral infections (such as the common cold or flu ). Unnecessary use or misuse of any antibiotic can lead to its decreased effectiveness.

How to use Hiprex

Take this medication by mouth as directed by your doctor. Dosage is based on the brand of methenamine you are prescribed, your medical condition, and your response to treatment. For children, dosage is also based on age and weight .

Methenamine works better if your urine is more acidic. Your doctor may test the acidity of your urine (urine pH). If necessary, your doctor may recommend ways to increase urine acidity (such as by taking vitamin C /drinking cranberry juice, limiting foods that decrease acidity/increase alkalinity such as milk products/most fruits, adjusting alkalinizing medications). See also Drug Interactions section. Follow your doctor's instructions.

Antibiotics work best when the amount of medicine in your body is kept at a constant level. Therefore, take this drug at evenly spaced intervals. To help you remember, take it at the same times each day.

Continue to take this medication for the full time prescribed, even if you feel well. Skipping doses or stopping the medication too early may allow bacteria to continue to grow, which may result in a return of the infection and make the bacteria more difficult to treat (resistant). Do not take more of this drug than directed because it may increase your chance of side effects.

Tell your doctor if symptoms of a urinary tract infection return (such as burning/painful/frequent urination ).

Side Effects

Nausea. vomiting. diarrhea. abdominal cramps. and loss of appetite may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Painful or difficult urination may occur with methenamine, although less often. Report these side effects to your doctor, who may need to lower your dose of methenamine or change your treatment to make your urine less acidic.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Taking higher than recommended doses of methenamine may cause bladder irritation, painful/frequent urination, and bloody/pink urine. Tell your doctor right away if you have any of these symptoms.

Tell your doctor right away if any of these unlikely but serious side effects occur: mouth sores, unusual headache. ringing in the ears. muscle cramps, swelling of the arms/legs.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction. including: rash. itching /swelling (especially of the face/tongue /throat), severe dizziness. trouble breathing .

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking methenamine, tell your doctor or pharmacist if you are allergic to it; or to formaldehyde; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney problems, liver problems, dehydration .

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy. this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

This drug passes into breast milk and the effect on a nursing infant is unknown. Consult your doctor before breast - feeding.

Interactions

See also How to Use section.

The effects of some drugs can change if you take other drugs or herbal products at the same time. This can increase your risk for serious side effects or may cause your medications not to work correctly. These drug interactions are possible, but do not always occur. Your doctor or pharmacist can often prevent or manage interactions by changing how you use your medications or by close monitoring.

To help your doctor and pharmacist give you the best care, be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products) before starting treatment with this product. While using this product, do not start, stop, or change the dosage of any other medicines you are using without your doctor's approval.

Some products that may interact with this drug include: sulfonamide drugs (including sulfa antibiotics such as sulfamethizole), products that decrease the amount of acid in the urine (urinary alkalinizers such as antacids, sodium bicarbonate. potassium or sodium citrate. carbonic anhydrase inhibitors such as acetazolamide ).

This medication may interfere with certain laboratory tests, possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

This document does not contain all possible drug interactions. Keep a list of all the products you use. Share this list with your doctor and pharmacist to lessen your risk for serious medication problems.

Overdose

If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Notes

Do not share this medication with others.

Laboratory and/or medical tests (such as urine tests, liver function tests ) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

This medication has been prescribed for your current condition only. Do not use it later for another infection unless your doctor directs you to do so. A different medication may be necessary in that case.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store at room temperature between 59-86 degrees F (15-30 degrees C) away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Information last revised October 2015. Copyright(c) 2015 First Databank, Inc.

Images

Zoltun Kulle - Diablo Wiki, Zoltem

Zoltun Kulle

This page provides information on Zoltun Kulle [ e ].

Are you looking for information on Zoltun Kulle (lore) the journal required for Judge of Character achievement? Are you looking for information on Zoltun Kulle conversation with Covetous Shen ?

Zoltun Kulle was one of the original, founding members of the Horadrim who took a precipitous turn towards evil. A mage of immense power, at one time he was the most dangerous man in the world of Sanctuary. To confront this threat, the forces of Sanctuary teamed together and worked in vain to destroy Zolton Kulle, as he had already discovered the secret to immortality. As a working solution to this, his head was severed and buried in the desert while his body was imprisoned in an alternate dimension. [1]

Contents

Background [ edit ]

Much of the background of Zoltun Kulle remains largely a mystery. The scholar, Abd al-Hazir. however, possessed one of the texts written by this Horadric mage: Demonicus de Zoltun Kulle . Abd al-Hazir used this text as a corroborating cross reference to the Vizjerei tomes he frequently consulted. However, the information in Vizjerei texts were highly suspect, as Abd al-Hazir describes:

"As my readers are well aware, early Vizjerei writings are often little more than self-serving propaganda aimed at whitewashing heinous deeds committed by the mage clan."

How Abd al-Hazir came by this records is unknown.

Brother of the Horadrim [ edit ]

Zoltun Kulle was among the founding members of the Horadrim, alongside six other mages. Records passed down from Jered Cain to his descendant, Deckard Cain. implied Zoltun Kulle was an accomplished member of the Ennead clain, implying implicit skill in transmutation, alteration and alchemy. While Kulle originally proved to be a noble and insightful addition to the Horadric brotherhood, the hunt for the three Prime Evils left him hollow and twisted. He endeavored to craft a soulstone empowered to contain the souls of angels and demons. While its creation may have originally been an attempt at repairing his broken spirit, an aspect of madness and hunger for power manifested itself. At some point in the throes of madness, Kulle was convinced that this singular Black Soulstone would prove critical in saving mankind from an unseen threat.

The remainder of the Horadrim learned of Zoltun Kulle's experiments. Under Jered Cain, the brotherhood hunted down their former comrade-in-arms. Although Kulle was acknowledged as being one of the most powerful beings in the world, the combined efforts of the Horadrim finally defeated him. The Black Soulstone, though left incomplete by Kulle, was never found.

Much to the chagrin of the Horadrim, Kulle's experiments had left him effectively immortal. They dismembered his body, isolating his head and draining his blood. Even so, Kulle's spirit remained restless and refused to leave the mortal plain.

Rise of the Nephalem [ edit ]

Centuries after Zoltun Kulle's defeat, the Prime Evils were released from their bondage and once more wreaked havoc on the world of Sanctuary. Diablo, Mephisto and Baal, empowered by the Soulstones that once bound them, rallied the armies of Hell and attempted to conquer humanity. However, a brave band of warriors retraced the steps of the Horadrim and defeated the Prime Evils one by one. In the end, only Baal, the Lord of Destruction, remained. He was successful at corrupting the World Stone, the monolithic artifact that hid the world from Heaven and Hell, as well as limited the power of humanity. After Baal's defeat, the archangel Tyrael obliterated the Worldstone. As a result, Baal's spirit was cast into the Black Abyss, and Sanctuary was unveiled to Heaven and Hell. Most importantly, its power restrictions over humanity were lifted, paving the way for the power of the Nephalem to resurface in humanity.

Twenty years later, the remaining lords of Hell, Belial and Azmodan, began their plans to conquer Sanctuary. A party of Nephalem emerged to counter the armies of Hell. In time, the adventurers crossed paths with Adria, a witch and former resident of Tristram. She discovered the Black Soulstone of Zoltun Kulle and posited it would be pivotal in turning the tide against Hell. The Black Soulstone would be capable of imprisoning all the lords of Hell, saving the world from their corruption forever. However, the Black Soulstone had been left incomplete, necessitating the revival of Zoltun Kulle himself.

Archives of Zoltun Kulle [ edit ]

The Archives of Zoltun Kulle was an area that was teased during Blizzcon 2011. Portions of it were playable in the Blizzcon 2009 floor demo and were the crumbling underground dungeons within the desert surrounding Caldeum.

The subterranean complex is a place of great power, with the relics of an age long past still humming with magical energy. Ancient wards and defenses were placed to guard the imprisoned head of Zoltun Kulle from the ill-intentioned seeking to restore or disturb the once great, Horadric mage.

The Archives of Zoltun Kulle will feature into the main quest of Diablo III in some way, but the pretext for the heroes' exploration of these ruins is still a mystery.

The Archives of Zoltun Kulle, lair of the twisted Horadric mage.

Boss Abilities [ edit ]

The boss encounter with Zoltun Kulle is a bit different from others as he begins the fight with two very large Sand Golems. called the Eternal Guardians. accompanying him. The sand golems have no real special abilities other than hitting hard, and occasionally performing a knockback attack.

Kulles abilities are listed below:

Fiery Boulder - Kulle will launch a fiery boulder at the player which explodes for AoE damage, leaving behind a desecrator - like lava pool.

Time Bubble - Similar to Slow Time. Kulle will erect a bubble right on top of a player that slows their movement and attack speed.

Ceiling Collapse - Kulle will laugh, and then strike his staff against the ground. The screen will shake, and loose rock from the ceiling will fall in a small area, dealing low damage.

Energy Twister - Similar to the Wizard 's Energy Twister. he will launch a whirling cone at the player which deals moderate damage, and normally this is cast when the time bubble is up.

Vanish - Kulle will vanish from sight in a puff of dust to re-appear somewhere else in the arena.

Creepy Laugh - Kulle will laugh, creeping out the player.

Inferno Difficulty - As of Patch 1.0.3. after 3 minutes, Kulle will teleport more frequently and inflict damage on the player upon arrival. This is Kulle's enrage timer .

Lore [ edit ]

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Pregnancy risk category D

Pharmacologic class: Alpha-adrenergic blocker

Therapeutic class: Anti-adrenergic

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For women with ductal carcinoma in situ or high risk of breast cancer, serious and life-threatening events associated with drug use in riskreduction setting include stroke, pulmonary embolism, and uterine cancer. Some of these events were fatal. Discuss potential benefits versus potential risks of these events with these patients. In women already diagnosed with breast cancer, drug's benefits outweigh risks.

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Adults: 20 to 40 mg P. O. daily for 5 years. Daily dosages of 20 mg may be taken as a single dose; daily dosages above 20 mg should be divided and taken b. i.d. (morning and evening).

➣ To reduce breast cancer incidence in high-risk women; treatment of ductal carcinoma in situ

Adults: 20 mg P. O. daily for 5 years

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• Mastalgia • Ovulation stimulation

Contraindications

• Hypersensitivity to drug • Concurrent warfarin use • Women with a history of deep-vein thrombosis or pulmonary embolism • Pregnancy or breastfeeding

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Use cautiously in: • decreased bone marrow reserve, leukopenia, thrombocytopenia, cataracts, hyperlipidemia • females of childbearing age.

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Adverse reactions

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CV: chest pain, deep-vein thrombosis

EENT: blurred vision, ocular lesion, retinopathy, corneal opacity

GI: nausea, vomiting, abdominal cramps, anorexia

GU: vaginal bleeding, discharge, or dryness; irregular menses; amenorrhea; oligomenorrhea; ovarian cyst; pruritus vulvae; endometrial or uterine cancer

Hematologic: leukopenia, thrombocytopenia

Metabolic: hypercalcemia, fluid retention

Musculoskeletal: bone pain

Respiratory: cough, pulmonary embolism

Skin: skin changes, hair thinning or partial hair loss

Other: altered taste, weight loss, tumor flare, tumor pain, hot flashes, edema

Interactions

Drug-drug . Aminoglutethimide, estrogens: decreased tamoxifen effects

Antineoplastics: increased risk of thromboembolic events

Bromocriptine: increased tamoxifen blood level

Warfarin: increased anticoagulant effect

Drug-diagnostic tests . Aspartate aminotransferase, bilirubin, calcium, creatinine, hepatic enzymes: increased levels

Platelets, white blood cells: decreased counts

Patient monitoring

• Monitor lipid panel, calcium level, mammography results, and gynecologic exam results.

Watch for signs and symptoms of thromboembolic events, including cerebrovascular accident and pulmonary embolism. • Monitor menstrual cycle pattern for changes that may signal endometrial or uterine cancer.

Patient teaching

• Tell patient to swallow enteric-coated tablets whole without breaking or crushing.

Instruct patient to immediately report leg or calf pain, swelling, or tenderness; unexpected shortness of breath; sudden chest pain; coughing up blood; new breast lumps; vaginal bleeding; menstrual irregularities; changes in vaginal discharge; pelvic pain or pressure; and vision changes. • Inform patient that increase in bone or tumor pain usually means drug will be effective. Advise her to discuss pain management with prescriber. • Stress importance of undergoing regular blood tests, mammograms, and gynecologic exams to identify early signs of serious adverse reactions. • As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs and tests mentioned above.

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Therapeutic class: Anti-adrenergic

Pregnancy risk category B

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The deal has been signed for Gelclair, an FDA-approved bioadherent oral rinse gel to treat the aching symptoms of oral mucositis (OM), as well as Soltamox (tamoxifen citrate) oral liquid solution, to be available to RainTree's Nationwide Oncology Membership.

Those factors include risks and uncertainties relating to DARA's ability to timely commercialize and generate revenues or profits from Bionect, Soltamox. Gelclair or other products given that DARA only recently hired its initial sales force and DARA's lack of history as a revenue-generating company, FDA and other regulatory risks relating to DARA's ability to market Bionect, Soltamox. Gelclair or other products in the U.

The Company has the exclusive United States marketing rights to its Soltamox (oral liquid tamoxifen).

As with other versions of tamoxifen, the SOLTAMOX product label also includes a black box warning with information on the potential risk of adverse events.

Soltamox is the only FDA-approved oral liquid version of tamoxifen citrate and fulfills a vital clinical need for patients who cannot tolerate existing solid tablet formulations of this drug.

DARA's three FDA-approved/cleared products (Bionect, Soltamox and Gelclair [sup.

QUADRAMET is approved for the treatment of pain in patients whose cancer has spread to the bone, PROSTASCINT is a PSMA-targeting monoclonal antibody-based agent to image the extent and spread of prostate cancer, and SOLTAMOX is the first liquid hormonal therapy approved in the U.

Those factors include risks and uncertainties relating to DARA's ability to timely commercialize and generate revenues or profits from Bionect[R], Soltamox [R], Gelclair[R] or other products given that DARA only recently hired its initial sales force and DARA's lack of history as a revenue-generating company, FDA and other regulatory risks relating to DARA's ability to market Bionect, Soltamox. Gelclair or other products in the U.

In particular, Cytogen's business is subject to a number of significant risks, which include, but are not limited to: the risk of successfully marketing SOLTAMOX and CAPHOSOL; the risk of obtaining the necessary regulatory approvals; the risk of whether products result from development activities; the risk of shifts in the regulatory environment affecting sales of Cytogen's products such as third - party payor reimbursement issues; the risk associated with Cytogen's dependence on its partners for development of certain projects, as well as other factors expressed from time to time in Cytogen's periodic filings with the Securities and Exchange Commission (the "SEC").

Funds Earmarked for Soltamox Commercial Activities, Gelclair Launch and Working Capital

Those factors include risks and uncertainties relating to DARA's ability to timely commercialize and generate revenues or profits from Bionect([R]), Soltamox ([R]), Gelclair([R]) or other products given that DARA only recently hired its initial sales force and DARA's lack of history as a revenue-generating company, FDA and other regulatory risks relating to DARA's ability to market Bionect, Soltamox. Gelclair or other products in the U.

In particular, Cytogen's business is subject to a number of significant risks, which include, but are not limited to: the risk of successfully marketing SOLTAMOX and CAPHOSOL; the risk of obtaining the necessary regulatory approvals; the risk of whether products result from development activities; the risk of shifts in the regulatory environment affecting sales of Cytogen's products such as third-party payor reimbursement issues; the risk associated with Cytogen's dependence on its partners for development of certain projects, as well as other factors expressed from time to time in Cytogen's periodic filings with the Securities and Exchange Commission (the "SEC").

Ciclofosfamida Medlineplus Medicinas, Ciclofosfamida

Ciclofosfamida

?Para cuales condiciones o enfermedades se prescribe este medicamento?

La ciclofosfamida se usa sola o en combinacion con otros medicamentos para tratar el linfoma de Hodgkin (enfermedad de Hodgkin) y linfoma no Hodgkin (tipos de cancer que empiezan en un tipo de globulo blanco cuya funcion es combatir las infecciones); linfoma cutaneo de celulas T (CTCL, por sus siglas en ingles) (un grupo de tipos de cancer del sistema inmunitario que aparecen inicialmente en forma de sarpullidos en la piel); mieloma multiple (un tipo de cancer de la medula osea); y determinados tipos de leucemia (cancer de los globulos blancos), que incluyen leucemia linfocitica cronica (CLL, por sus siglas en ingles), leucemia mielogena cronica (CML, por sus siglas en ingles), leucemia mieloide aguda (AML y ANLL, por sus siglas en ingles), y leucemia linfoblastica aguda (ALL, por sus siglas en ingles). Tambien se utiliza para tratar el retinoblastoma (cancer en los ojos), el neuroblastoma (cancer que empieza en las celulas nerviosas que afecta principalmente a los ninos), cancer de ovario (cancer que empieza en los organos reproductores femeninos donde se forman los ovulos) y cancer de seno. La ciclofosfamida tambien se usa para tratar el sindrome nefrotico (una enfermedad provocada por dano en los rinones) en los ninos en los que la enfermedad no ha mejorado, ha empeorado o ha vuelto a aparecer despues de tomar otros medicamentos, o en los ninos que han experimentado efectos secundarios intolerables con otros medicamentos. La ciclofosfamida pertenece a una clase de medicamentos llamados agentes alquilantes. Cuando la ciclofosfamida se usa para tratar el cancer, actua retardando o deteniendo el crecimiento de las celulas cancerosas en su cuerpo. Cuando la ciclofosfamida se usa para tratar el sindrome nefrotico, actua suprimiendo el sistema inmunitario del cuerpo.

?Como se debe usar este medicamento?

La presentacion de la ciclofosfamida es en tabletas y en capsulas para administrarse por via oral una vez al dia. La duracion del tratamiento depende del tipo de medicamentos que este tomando, de la manera en que su cuerpo responda a ellos y del tipo de cancer o afeccion que tenga. Tome la ciclofosfamida aproximadamente a la misma hora todos los dias. Siga atentamente las instrucciones del medicamento recetado, y pidales a su medico o a su farmaceutico que le expliquen cualquier cosa que no entienda. Tome la ciclofosfamida segun lo indicado. No aumente ni disminuya la dosis, ni la tome con mas frecuencia que la indicada por su medico.

Es posible que su medico necesite posponer su tratamiento o ajustar su dosis de ciclofosfamida segun su respuesta al tratamiento y segun los efectos secundarios que tenga. Hable con su medico acerca de como se siente durante su tratamiento. No deje de tomar la ciclofosfamida sin consultar a su medico.

?Que otro uso se le da a este medicamento?

La ciclofosfamida tambien se usa a veces para tratar un determinado tipo de cancer de pulmon (cancer de pulmon de celulas pequenas; SCLC, por sus siglas en ingles). Tambien se usa para tratar el rabdomiosarcoma (un tipo de cancer de los musculos) y el sarcoma de Ewing (un tipo de cancer oseo) en los ninos. Consulte a su medico sobre los riesgos de usar este medicamento para tratar su afeccion.

Este medicamento puede recetarse para otros usos; pidales mas informacion a su medico o a su farmaceutico.

?Cuales son las precauciones especiales que debo seguir?

Antes de tomar la ciclofosfamida:

Informe a su medico y a su farmaceutico si es alergico a la ciclofosfamida, a otros agentes alquilantes como la bendamustina (Treanda ® ), el busulfan (Myerlan ®. Busulfex ® ), la carmustina (BiCNU ®. Gliadel ® Wafer), el clorambucilo (Leukeran ® ), la ifosfamida (Ifex ® ), la lomustina (CeeNU ® ), el melfalan (Alkeran ® ), la procarbazina (Mutalane ® ) o la temozolomida (Temodar ® ), a algun otro medicamento o a alguno de los ingredientes de la ciclofosfamida. Pidale a su farmaceutico una lista de los ingredientes.

Informe a su medico y a su farmaceutico que otros medicamentos con y sin receta, vitaminas, suplementos nutricionales y productos herbarios esta tomando o planea tomar. No olvide mencionar ninguno de los siguientes: alopurinol (Zyloprim ® ), acetato de cortisona, doxorrubicina (Adriamycin ®. Doxil ® ), hidrocortisona (Cortef ® ) o fenobarbital (Luminal ® Sodium). Es posible que su medico deba cambiar las dosis de sus medicamentos o vigilarlo de cerca por si presentara efectos secundarios. Muchos otros medicamentos tambien pueden interactuar con la ciclofosfamida, por lo que no olvide informar a su medico sobre todos los medicamentos que este tomando, incluso los que no aparezcan en esta lista.

Informe a su medico si previamente ha recibido tratamiento con otros medicamentos usados en la quimioterapia o si recientemente le han hecho una radiografia. Ademas, informe a su medico si tiene o alguna vez ha tenido enfermedad del rinon o del higado.

Tenga en cuenta que la ciclofosfamida puede interferir en el ciclo (periodo) menstrual normal en las mujeres y detener la produccion de espermatozoides en los hombres. La ciclofosfamida puede provocar infertilidad (dificultad para quedar embarazada) permanente; no obstante, eso no significa que usted no pueda quedar embarazada o dejar embarazada a otra persona. Las mujeres embarazadas o que estan dando el pecho deben decirselo a su medico antes de empezar a tomar este medicamento. No debe quedar embarazada mientras este en tratamiento con quimioterapia o por un tiempo despues de los tratamientos.(Hable con su medico para que le de mas informacion). Use un metodo anticonceptivo confiable para evitar el embarazo. La ciclofosfamida puede causarle danos al feto.

Si se va a realizar una cirugia, incluso una cirugia dental, informe al medico o al dentista que esta tomando ciclofosfamida.

?Que dieta especial debo seguir mientras tomo este medicamento?

Documento actualizado - 15/09/2011

American Society of Health-System Pharmacists, Inc. Clausula de Proteccion

AHFS ® Patient Medication Information. © Copyright, 2016. The American Society of Health-System Pharmacists, Inc. 7272 Wisconsin Avenue, Bethesda, Maryland. Todos los derechos reservados. La duplicacion de este documento para su uso comercial, debera ser autorizada por ASHP. Traducido del ingles por HolaDoctor.

Furosemide - Brand Name List From, Furosetron

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See also.

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Chemical formula: C12H11ClN2O5S Drugbank ID: DB00695 ATC code(s): C03CA01, C03CB01, C03EB01

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Mirzalux - ?Tu Colega Siempre En Linea, Mirzalux

MIRZALUX

MIRZALUX TABLETAS Antidepresivo SANDOZ, S. A. de C. V.

- DENOMINACION GENERICA - FORMA FARMACEUTICA Y FORMULACION - INDICACIONES TERAPEUTICAS - FARMACOCINETICA Y FARMACODINAMIA EN HUMANOS - CONTRAINDICACIONES - PRECAUCIONES GENERALES - RESTRICCIONES DE USO DURANTE EL EMBARAZO Y LA LACTANCIA - REACCIONES SECUNDARIAS Y ADVERSAS - INTERACCIONES MEDICAMENTOSAS Y DE OTRO GENERO - ALTERACIONES EN LOS RESULTADOS DE PRUEBAS DE LABORATORIO - PRECAUCIONES EN RELACION CON EFECTOS DE CARCINOGENESIS, MUTAGENESIS, TERATOGENESIS Y SOBRE LA FERTILIDAD - DOSIS Y VIA DE ADMINISTRACION - MANIFESTACIONES Y MANEJO DE LA SOBREDOSIFICACION O INGESTA ACCIDENTAL - PRESENTACIONES - RECOMENDACIONES SOBRE ALMACENAMIENTO - LEYENDAS DE PROTECCION - LABORATORIO Y DIRECCION - NUMERO DE REGISTRO Y CLAVE IPPA

FORMA FARMACEUTICA Y FORMULACION:

Antidepresivo. Episodios de depresion mayor, leve, moderada o severa.

FARMACOCINETICA Y FARMACODINAMIA EN HUMANOS:

Caracteristicas farmacocineticas: Despues de la administracion oral de MIRZALUX® Tabletas, el componente activo mirtazapina es rapida y adecuadamente absorbido (biodisponibilidad = 50%), alcanzando niveles maximos en plasma despues de aproximadamente 2 horas. La union de la mirtazapina a las proteinas plasmaticas es aproximadamente de 85%. La vida media de eliminacion en promedio es de 20 a 40 horas; ocasionalmente se han registrado vidas medias mas prolongadas, hasta de 65 horas, asi como vidas medias mas cortas han sido observadas en hombres jovenes. La vida media de eliminacion es suficiente para justificar la administracion una vez al dia.

El estado estable plasmatico se alcanza despues de 3 a 4 dias, despues de lo cual no existe acumulacion adicional. La mirtazapina muestra una farmacocinetica lineal, dentro del rango de la dosis recomendada. La mirtazapina es extensamente metabolizada y eliminada a traves de la orina y las heces dentro de algunos dias. Las principales vias de biotransformacion son la desmetilacion y la oxidacion, seguidas de la conjugacion. El metabolito desmetilado es farmacologicamente activo y parece tener el mismo perfil farmacocinetico que el compuesto relacionado. La depuracion de la mirtazapina parece disminuir como resultado de la insuficiencia hepatica y renal.

Caracteristicas farmacodinamicas: La mirtazapina es un antagonista presinaptico de los receptores alfa2 activo a nivel central, que aumenta la neurotransmision serotoninergica y adrenergica central. La mejoria de la neurotransmision serotoninergica esta especificamente mediada a traves de los receptores 5-HT1, debido a que los receptores 5-HT2 y 5-HT3 son bloqueados por la mirtazapina.

Se supone que ambos enantiomeros de la mirtazapina contribuyen a la actividad antidepresiva, el enantiomero S (+) bloqueando a los receptores alfa2 y 5-HT2 y el enantiomero R (-) bloqueando a los receptores 5-HT3. La actividad antagonista de los receptores H1 de la histamina que ejerce la mirtazapina es responsable de su actividad sedante.

La mirtazapina generalmente es bien tolerada. Practicamente carece de actividad anticolinergica y a dosis terapeuticas practicamente no tiene efectos sobre el sistema cardiovascular.

Hipersensibilidad a la mirtazapina, menores de 18 anos.

Con la mayoria de los antidepresivos se ha reportado el desarrollo de depresion de la medula osea durante el tratamiento oral, que usualmente se manifiesta como granulocitopenia o agranulocitosis. Esto se manifiesta usualmente despues de 4 a 6 semanas de tratamiento y es generalmente reversible despues de terminar el tratamiento. Tambien se ha reportado agranulocitosis reversible como evento raro en los estudios clinicos realizados con MIRZALUX®. El medico debe estar alerta de sintomas como fiebre, irritacion faringea, estomatitis u otros signos de infeccion; cuando se presenten estos sintomas, el tratamiento debera suspenderse y realizar biometrias hematicas.

Al igual que otros antidepresivos, se debera tener cuidado en los pacientes con:

Alteraciones de la miccion secundaria a hipertrofia de prostata (aun cuando no son de esperarse problemas debido a que MIRZALUX® posee unicamente una muy debil actividad anticolinergica). Glaucoma de angulo estrecho en fase aguda y aumento de la presion intraocular (tambien en estos casos existe muy poca posibilidad de que se produzcan alteraciones con MIRZALUX®, debido a su muy debil actividad anticolinergica). Diabetes mellitus. El tratamiento debera suspenderse si aparece ictericia. Por otra parte, al igual que otros agentes antidepresivos, los siguientes eventos deberan tomarse en consideracion: Puede ocurrir empeoramiento de los sintomas psicoticos cuando se administran antidepresivos a pacientes con esquizofrenia u otras alteraciones psicoticas; se considera que pueden intensificarse los pensamientos paranoides. Cuando se da tratamiento a la fase depresiva de la psicosis maniaco-depresiva, se puede pasar a la fase maniaca. Con respecto a la posibilidad de suicidio, en particular al inicio del tratamiento, debera darse un numero limitado de tabletas de MIRZALUX® al paciente. Aun cuando los antidepresivos no causan adiccion, la terminacion abrupta del tratamiento despues de un periodo prolongado con el medicamento puede producir sintomas como nausea, cefalea y malestar general. Los pacientes ancianos generalmente son mas sensibles, especialmente en lo que respecta a los efectos secundarios de los antidepresivos. Durante los estudios clinicos realizados con MIRZALUX®, los efectos secundarios no fueron reportados con una frecuencia mayor en los pacientes ancianos que en otros grupos de edad; sin embargo, la experiencia hasta ahora es limitada. MIRZALUX® puede alterar la concentracion y el estado de alerta. Los pacientes tratados con antidepresivos deberan evitar realizar tareas potencialmente peligrosas que requieran del estado de alerta y una buena concentracion, como manejar un vehiculo motorizado u operar maquinaria.

RESTRICCIONES DE USO DURANTE EL EMBARAZO Y LA LACTANCIA:

Aun cuando los estudios en animales no demostraron ningun efecto teratogenico de importancia toxicologica, no se ha establecido la seguridad de MIRZALUX® en el embarazo humano. MIRZALUX® podra ser utilizado durante el embarazo unicamente si esta claramente indicado.

Aun cuando los experimentos en animales mostraron que la mirtazapina se excreta unicamente en cantidades muy pequenas en la leche, no se recomienda el uso de MIRZALUX® en mujeres en lactacion, debido a que no se dispone de informacion en humanos acerca del paso del medicamento a la leche materna.

REACCIONES SECUNDARIAS Y ADVERSAS:

Los pacientes deprimidos presentan una serie de sintomas que estan asociados a la enfermedad misma. Por lo tanto, algunas veces es dificil identificar cuales sintomas son producidos por la enfermedad misma y cuales son el resultado del tratamiento con MIRZALUX®.

Los efectos adversos mas comunmente reportados durante el tratamiento con MIRZALUX®, son:

Aumento del apetito y ganancia ponderal. Somnolencia/sedacion, que generalmente ocurre durante las primeras semanas del tratamiento (nota: la reduccion de la dosis generalmente no conduce a la disminucion de la sedacion, pero puede aminorar la eficacia antidepresiva). Pueden ocurrir los siguientes efectos secundarios en raros casos: Hipotension (ortostatica). Mania. Convulsiones (induccion), tremor, mioclonia. Edema que se acompana de aumento de peso corporal. Depresion aguda de la medula osea (eosinofilia, granulocitopenia, agranulocitosis, anemia aplasica y trombocitopenia). Elevacion de las transaminasas sericas. Exantema. INTERACCIONES MEDICAMENTOSAS Y DE OTRO GENERO

La mirtazapina puede potenciar la accion sedante del alcohol sobre el sistema nervioso central; los pacientes deberan, por lo tanto, ser aconsejados de evitar el consumo de alcohol durante el tratamiento con MIRZALUX®.

MIRZALUX® no debera administrarse concomitantemente con inhibidores de la MAO ni dentro de las 2 semanas de haber suspendido la terapia con estos agentes. La mirtazapina puede potenciar los efectos sedantes de las benzodiazepinas; debera tenerse cuidado cuando estos dos agentes se prescriban concomitantemente co

ALTERACIONES EN LOS RESULTADOS DE PRUEBAS DE LABORATORIO:

En raros casos se ha observado incremento de las transaminasas hepaticas.

PRECAUCIONES EN RELACION CON EFECTOS DE CARCINOGENESIS, MUTAGENESIS, TERATOGENESIS Y SOBRE LA FERTILIDAD:

No se han realizado estudios de carcinogenicidad con la mirtazapina. Los estudios en animales no han demostrado ningun efecto teratogenico de importancia toxicologica. Este medicamento no modifica la fertilidad.

DOSIS Y VIA DE ADMINISTRACION:

Las tabletas deben ser ingeridas por via oral, de ser necesario con liquidos y ser deglutidas sin masticar.

Adultos: El tratamiento debe iniciarse con 15 mg al dia. La dosis generalmente requiere ser incrementada para obtener una respuesta clinica optima.

La dosis diaria efectiva es usualmente entre 15 y 45 mg.

Ancianos: La dosis recomendada es la misma que para los adultos. En los pacientes ancianos, los incrementos de las dosis deberan realizarse bajo una supervision estrecha, hasta obtener una respuesta segura y satisfactoria.

Ninos: Debido a que no se ha establecido la seguridad y eficacia de MIRZALUX® en los ninos, no se recomienda el tratamiento con MIRZALUX® en esta poblacion.

La velocidad de depuracion de la mirtazapina puede estar disminuida en los pacientes con insuficiencia hepatica o renal. Esto debera tomarse en consideracion al prescribir MIRZALUX® a este tipo de pacientes. La mirtazapina tiene una vida media de 20 a 40 horas y, por lo tanto, MIRZALUX® es ideal para ser administrado una vez al dia. Debera tomarse preferentemente como dosis unica por la noche, antes de acostarse a dormir. Asimismo, MIRZALUX® tambien puede administrarse en dos dosis igualmente divididas (una toma por la manana y otra por la noche). El tratamiento debera preferentemente ser continuado hasta que el paciente se encuentre completamente libre de sintomas durante 4 a 6 meses. Despues de este periodo, el tratamiento puede ser gradualmente discontinuado. El tratamiento con una dosis adecuada producira una respuesta positiva dentro de las 2 a 4 semanas siguientes. En caso de una respuesta insuficiente dentro de las 2 a 4 semanas, se puede aumentar la dosis hasta la dosis maxima. Si no hay respuesta en las siguientes 2 a 4 semanas, habra de suspenderse el tratamiento.

Se requiere un cuidadoso ajuste de la dosis y de un estrecho monitoreo en forma regular, en pacientes con:

Epilepsia y sindrome organico cerebral; de la experiencia clinica se observo que en pacientes tratados con MIRZALUX®, el medicamento parece producir raramente agudizacion de estos cuadros. Insuficiencia hepatica y renal. Enfermedades cardiacas como alteraciones de la conduccion, angina de pecho e infarto reciente del miocardio, donde se deben tomar las precauciones normales y administrarse con cuidado los medicamentos concomitantes. Presion arterial baja. MANIFESTACIONES Y MANEJO DE LA SOBREDOSIFICACION O INGESTA ACCIDENTAL:

No se ha establecido la seguridad clinica de MIRZALUX® en casos de sobredosificacion. Los estudios de toxicidad demostraron que los efectos de cardiotoxicidad clinicamente relevantes, no se presentaron con la sobredosificacion de MIRZALUX®. En los estudios clinicos de MIRZALUX®, ademas de la sedacion excesiva, no se observaron efectos clinicamente importantes con la sobredosificacion. Los casos de sobredosis deben ser tratados con lavado gastrico y la administracion del tratamiento sintomatico y de apoyo para las funciones vitales.

Caja con 30 tabletas de 15 mg.

Caja con 30 tabletas de 30 mg.

RECOMENDACIONES SOBRE ALMACENAMIENTO:

Conservese a temperatura ambiente a no mas de 30°C y en lugar seco. Protejase de la luz.

LEYENDAS DE PROTECCION:

Dosis: la que el medico senale. Su venta requiere receta medica. Via de administracion: oral. No se deje al alcance de los ninos.

LABORATORIO Y DIRECCION: Hecho en Espana por: Kern Pharma, SL, Barcelona

Distribuido por: SANDOZ, S. A. de C. V. A Novartis Company Calle Candelaria No. 186 Colonia Atlantida, 04370 Mexico, D. F. ® Marca registrada

NUMERO DE REGISTRO Y CLAVE IPPA: Reg. Num. 158M2005, S. S.A. IV DEAR-05330020510783/RM2006/IPPA

Dolotec And Risperdal Drug Interactions, Dolotec

Drug interactions between Dolotec and Risperdal

Drug Interaction Classification

The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.

Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.

Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.

Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Do not stop taking any medications without consulting your healthcare provider.

Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Multum's information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2016 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.

How to Prevent Deadly Drug Interactions

Some mixtures of medications can lead to serious and even fatal consequences.

Yosprala Yosprala (aspirin and omeprazole) is a platelet aggregation inhibitor and proton pump inhibitor.

Cuvitru Cuvitru (immune globulin subcutaneous (human)) is indicated as replacement therapy in the treatment.

Erelzi Erelzi (etanercept-szzs) is a tumor necrosis factor (TNF) blocker biosimilar to Enbrel indicated.

Troxyca ER Troxyca ER (oxycodone hydrochloride and naltrexone hydrochloride) is an extended-release.

FDA Consumer Updates

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Depacon Indications, Side Effects, Warnings, Depicor

Depacon

Generic Name: valproate (val-PROE-ate) Brand Name: Depacon

Liver failure and death from liver failure has occurred in patients taking Depacon. This has usually occurred within the first 6 months of treatment. Tell your doctor right away if you notice symptoms of liver problems (eg, a general feeling of discomfort, sluggishness, unusual tiredness or weakness, swelling of the face, loss of appetite, vomiting, stomach pain, dark urine, pale stools, or yellowing of the skin or eyes). In patients who have seizures, loss of seizure control may occur. You should have lab tests done before and during treatment to check for liver problems. Be sure to keep all doctor and lab appointments.

Children younger than 2 years old have an increased risk of fatal liver problems, especially if they take more than 1 seizure medicine or have a metabolic disorder, a severe seizure disorder along with mental retardation, or organic brain disease. Discuss any questions or concerns with your doctor.

There is an increased risk of liver failure and death from liver failure in patients who have a genetic liver problem caused by a mitochondrial disorder (eg, Alpers-Huttenlocher syndrome). You may need to have a special genetic test to check for this condition. Certain patients who have known or suspected mitochondrial disorders should not take Depacon. Talk with your doctor for more information.

Depacon can cause severe birth defects if it is used during pregnancy. It can also cause the child to have a lower IQ. Do not take Depacon to prevent migraine headaches if you are pregnant. If you are pregnant and take Depacon for seizures or bipolar disorder, talk to your doctor to decide if you will continue to take Depacon.

If you are able to become pregnant, you must use an effective form of birth control while you take Depacon. Contact your doctor right away if you become pregnant or think you may be pregnant while taking Depacon.

Depacon comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Depacon refilled.

Severe and sometimes fatal pancreas problems (pancreatitis) have occurred with the use of Depacon. This has been reported shortly after starting treatment as well as after several years of use. Seek immediate medical attention if you notice any stomach pain, nausea, vomiting, or loss of appetite.

Depacon is used for:

Controlling certain types of seizures in the treatment of epilepsy in patients who are unable to take the oral form of Depacon. It may also be used for other conditions as determined by your doctor.

Depacon is an anticonvulsant. It works by increasing a certain chemical in the brain.

Do NOT use Depacon if:

you are allergic to any ingredient in Depacon

you have liver problems or a urea cycle disorder

you have a genetic liver problem caused by a mitochondrial disorder (eg, Alpers-Huttenlocher syndrome)

the patient is younger than 2 years old and has a mitochondrial disorder

you are taking Depacon to prevent migraine headaches and you are pregnant

Contact your doctor or health care provider right away if any of these apply to you.

Before using Depacon:

Some medical conditions may interact with Depacon. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, are breast-feeding, or are of childbearing age

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of liver problems, cancer, blood disease (eg, low levels of white blood cells, low blood platelet levels), HIV infection, cytomegalovirus (CMV) infection, kidney problems, pancreas problems, low blood albumin levels, or high blood glycine levels

if you have a history of metabolic problems, ornithine transcarbamylase deficiency, brain problems (eg, organic brain disease), coma, high blood ammonia or glutamine levels, low body temperature, mental retardation, recurring vomiting and sluggishness, or recurring extreme irritability

if you have a history of mental or mood problems, suicidal thoughts or actions, or alcohol abuse or dependence

if you have decreased food or fluid intake, or if you are scheduled for surgery

if you have a family history of urea cycle disorders or unexplained infant deaths

if you take any other medicine for seizures

Some MEDICINES MAY INTERACT with Depacon. Tell your health care provider if you are taking any other medicines, especially any of the following:

Clonazepam because the risk of seizures may be increased

Topiramate because the risk of high ammonium levels and brain problems may be increased

Benzodiazepines (eg, diazepam), felbamate, or salicylates (eg, aspirin) because they may increase the risk of Depacon's side effects

Carbamazepine, carbapenem antibiotics (eg, imipenem), hormonal birth control (eg, birth control pills), hydantoins (eg, phenytoin), mefloquine, rifampin, or ritonavir because they may decrease Depacon's effectiveness

Anticoagulants (eg, warfarin), barbiturates (eg, phenobarbital, primidone), ethosuximide, lamotrigine, methylphenidate, quetiapine, rufinamide, tolbutamide, tricyclic antidepressants (eg, amitriptyline), or zidovudine because the risk of their side effects may be increased by Depacon

This may not be a complete list of all interactions that may occur. Ask your health care provider if Depacon may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Depacon:

Use Depacon as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Depacon is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Depacon at home, a health care provider will teach you how to use it. Be sure you understand how to use Depacon. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.

Do not use Depacon if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.

Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.

Do not suddenly stop using Depacon. Suddenly stopping Depacon may cause seizures to occur more often. If you need to stop Depacon, your doctor will gradually lower your dose.

Depacon works best if it is used at the same time each day.

Continue to use Depacon even if you feel well. Do not miss any doses.

If you miss a dose of Depacon, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Depacon.

Important safety information:

Depacon may cause dizziness, drowsiness, or vision changes. These effects may be worse if you take it with alcohol or certain medicines. Use Depacon with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

Check with your doctor before you drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Depacon; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.

Patients who take Depacon may be at increased risk for suicidal thoughts or actions. The risk may be greater in patients who have had suicidal thoughts or actions in the past. Watch patients who take Depacon closely. Contact the doctor at once if new, worsened, or sudden symptoms, such as depressed mood; anxious, restless, or irritable behavior; panic attacks; or any unusual change in mood or behavior, occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur.

Inflammation of the pancreas is a potentially life-threatening illness associated with Depacon. Symptoms include stomach pain, vomiting, or loss of appetite. Contact your doctor at once if any of these symptoms occur.

A very bad and sometimes deadly reaction has happened with this drug. Most of the time, this reaction has signs like fever, rash, or swollen glands with problems in body organs like the liver, kidney, blood, heart, muscles and joints, or lungs. Talk with the doctor.

Depacon may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.

Tell your doctor or dentist that you use Depacon before you receive any medical or dental care, emergency care, or surgery.

Certain brain problems have happened with the use of valproic acid products. Sometimes, these problems have led to health problems that may not go away. Discuss any questions or concerns with your doctor.

Diabetes patients - Depacon may cause the results of some tests for urine ketones to be wrong. Ask your doctor before you change your diet or the dose of your diabetes medicine.

Depacon may interfere with certain lab tests, including thyroid function. Be sure your doctor and lab personnel know you are taking Depacon.

Lab tests, including complete blood cell counts and liver function, may be performed while you use Depacon. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Depacon with caution in the ELDERLY; they may be more sensitive to its effects, especially drowsiness.

Depacon has been shown to cause harm to the fetus. If you may become pregnant, discuss other possible treatment options with your doctor. If a decision is made to take Depacon, use effective birth control while you are taking it. Talk with your doctor if you are planning to become pregnant, or if you have questions or concerns about this information.

PREGNANCY and BREAST-FEEDING: Depacon has been shown to cause harm to the fetus. If you think you may be pregnant, contact your doctor right away. You will need to discuss the benefits and risks of using Depacon while you are pregnant. You and your doctor will need to decide if you will continue to take Depacon while you are pregnant. Depacon is found in breast milk. Do not breast-feed while you are using Depacon.

Possible side effects of Depacon:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Change in appetite; constipation; diarrhea; dizziness; drowsiness; hair loss; headache; indigestion; mild pain or redness at the injection site; nausea; stomach cramps or pain; trouble sleeping; vomiting; weakness; weight changes.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing or swallowing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue); abnormal thinking; blurred vision or other vision changes; changes in behavior; change in menstrual period; chest pain; chills; confusion; difficulty speaking; difficulty urinating or other urination problems; extreme tiredness; fainting; fast or irregular heartbeat; fever; general body discomfort; hallucinations; hearing loss; involuntary movements of the arms and legs; involuntary movements or chewing movements of the face, jaw, mouth, or tongue; joint or muscle pain or weakness; lack of energy; loss of coordination; memory loss; new or worsening mental or mood changes (eg, aggressiveness, agitation, anxiety, depression, exaggerated feeling of well-being, hostility, impulsiveness, inability to sit still, irritability, panic attacks, restlessness); new or worsening seizures; nosebleed; red, swollen, blistered, or peeling skin; ringing in the ears; severe or persistent nausea, vomiting, or stomach pain; severe or persistent pain; shortness of breath; sore throat; suicidal thoughts or actions; swelling of the arms or legs; swollen lymph nodes; symptoms of liver problems (eg, dark urine, loss of appetite, pale stools, severe stomach pain, yellowing of the skin or eyes); tremor; unusual bleeding or bruising; unusual weakness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA .

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center. or emergency room immediately.

Proper storage of Depacon:

Store the undiluted solution of Depacon at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Because the product does not contain a preservative, any unused mixed portion should be discarded. Depacon is stable for 24 hours when added to compatible intravenous solutions and stored in glass or polyvinyl chloride (PVC) bags at room temperature between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Depacon out of the reach of children and away from pets.

General information:

If you have any questions about Depacon, please talk with your doctor, pharmacist, or other health care provider.

Depacon is to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take Depacon or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Depacon. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Depacon. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using Depacon.

Review Date: August 8, 2016

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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Take Metoclopramide by mouth 30 minutes before meals unless directed otherwise by your doctor.

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you are allergic to any ingredient in Metoclopramide

you have seizures (eg, epilepsy); bleeding, blockage, or perforation in your stomach or intestines; or tumors on your adrenal gland (pheochromocytoma)

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you are taking medicines, such as phenothiazines (eg, chlorpromazine), that may cause extrapyramidal reactions (abnormal, involuntary muscle movements of the head, neck, or limbs). Check with your doctor if you are unsure if any of your medicines may cause extrapyramidal reactions.

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Some medicines may interact with Metoclopramide. Tell your health care provider if you are taking any other medicines, especially any of the following:

Monoamine oxidase inhibitors (MAOIs) (eg, phenelzine) because the risk of serious side effects (eg, high blood pressure, seizures) may be increased

Anticholinergic medicine (eg, hyoscyamine) or narcotic pain medicines (eg, codeine) because they may decrease Metoclopramide's effectiveness

Acetaminophen, benzodiazepines (eg, diazepam), cyclosporine, insulin, levodopa, phenothiazines (eg, chlorpromazine), sedatives (eg, zolpidem), selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine), succinylcholine, or tetracycline because the risk of their side effects may be increased by Metoclopramide

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Do NOT take more than the recommended dose or use Metoclopramide for longer than 12 weeks without checking with your doctor.

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Tell your doctor or dentist that you take Metoclopramide before you receive any medical or dental care, emergency care, or surgery.

Neuroleptic malignant syndrome (NMS) is a possibly fatal syndrome that can be caused by Metoclopramide. Symptoms may include fever; stiff muscles; confusion; abnormal thinking; fast or irregular heartbeat; and sweating. Contact your doctor at once if you have any of these symptoms.

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Lab tests, including liver and kidney function tests, may be performed while you use Metoclopramide. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Metoclopramide with caution in the elderly; they may be more sensitive to its effects, especially drowsiness, confusion, and uncontrolled muscle movements, including tardive dyskinesia.

Metoclopramide should be used with extreme caution in children; safety and effectiveness in children have not been confirmed. The risk of developing uncontrolled muscle movements may be greater in children.

Pregnancy and breast feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Metoclopramide while you are pregnant. Metoclopramide is found in breast milk. If you are or will be breast-feeding while you use Metoclopramide, check with your doctor. Discuss any possible risks to your baby.

A small number of patients have experienced withdrawal symptoms when stopping Metoclopramide. These symptoms may include dizziness, nervousness, and headache.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Decreased energy; diarrhea; dizziness; drowsiness; headache; nausea; restlessness; tiredness; trouble sleeping.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); abnormal thinking; confusion; dark urine; decreased balance or coordination; decreased sexual ability; fast, slow, or irregular heartbeat; fever; hallucinations; loss of bladder control; mental or mood changes (eg, depression, anxiety, agitation, jitteriness); seizures; severe or persistent dizziness, headache, or trouble sleeping; severe or persistent restlessness, including inability to sit still; shortness of breath; stiff or rigid muscles; sudden increased sweating; sudden, unusual weight gain; suicidal thoughts or actions; swelling of the arms, legs, or feet; uncontrolled muscle spasms or movements (eg, of the arms, legs, tongue, jaw, cheeks; twitching; tremors); vision changes; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking clarithromycin, tell your doctor or pharmacist if you are allergic to it; or to other macrolide antibiotics (such as erythromycin. azithromycin ); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease (including liver problems with past clarithromycin use), kidney disease. a certain type of muscle disease (myasthenia gravis ).

Clarithromycin may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.

The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using clarithromycin, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (heart failure. slow heartbeat, QT prolongation in the EKG ), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).

Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/"water pills") or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using clarithromycin safely.

Clarithromycin may cause live bacterial vaccines (such as typhoid vaccine) not to work as well. Therefore, do not have any immunizations/vaccinations while using this medication without the consent of your doctor.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Older adults may be more sensitive to the side effects of this drug, especially hearing loss and QT prolongation (see above).

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

This medication passes into breast milk. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

A product that may interact with this drug is: clindamycin.

Many drugs besides clarithromycin may affect the heart rhythm (QT prolongation), including amiodarone, dofetilide, pimozide, procainamide, quinidine, sotalol, among others.

Other medications can affect the removal of clarithromycin from your body, which may affect how clarithromycin works. Examples include rifamycins (such as rifabutin), efavirenz, nevirapine, among others.

Clarithromycin can slow down the removal of other medications from your body, which may affect how they work. Examples of affected drugs include apixaban, colchicine, digoxin, some drugs used to treat erectile dysfunction-ED/pulmonary hypertension (such as sildenafil, tadalafil), ergot alkaloids (such as ergotamine, dihydroergotamine), some statin drugs (such as lovastatin, simvastatin), tamsulosin, tolvaptan, ticagrelor, among others.

Although most antibiotics are unlikely to affect hormonal birth control such as pills, patch, or ring, a few antibiotics (such as rifampin, rifabutin) can decrease their effectiveness. This could result in pregnancy. If you use hormonal birth control, ask your doctor or pharmacist for more details.

Overdose

If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Notes

Do not share this medication with others.

This medication has been prescribed for your current condition only. Do not use it later for another infection unless your doctor directs you to do so. A different medication may be necessary in that case.

Laboratory and/or medical tests (such as cultures, liver or kidney function tests) may be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Information last revised February 2016. Copyright(c) 2016 First Databank, Inc.

Images

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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Profood - Food Ingredient Supplier And Distributor, Nifin

The bacteriocin nisin is a natural antimicrobial agent with activity against a wide variety of undesirable food borne (pathogenic) bacteria. It is a peptide which is produced by the food grade dairy starter bacterium Lactococcus lactis. Nisin is used as a preservative in heat processed and low pH foods. Nisin cannot be synthesised chemically, so the nisin-producing L. lactis bacteria are used for the synthesis of nisin. A nisin preparation is applied as a concentrate of dry material derived from the controlled fermentation of L. lactis.

Structure of Biopreservation with Nisin

. Purposes of the Usage

The purposes of application of nisin in foods are multifold:

1) Extend shelf life

2). Cost saving for food processors

Reduce the temperature of the heat processing

Shorten the time of the heat processing.

Protect against temperature abuse of chilled products during storage and distribution.

In certain cases use ambient instead of chilled condition for storage and distribution.

3). Ensure Food Safety

Nisin is effective in controlling of pathogenic/food poisoning organisms such as Listeria, Bacillus cereus and Clostridium botulinum as part of an overall safe processing system.

4). Improve Food Quality

Usage Directions and Recommendations

U. S. FDA?s Gras notice indicated that for use on casings for frankfurters and on cooked meat and poultry products as an antimicrobial agent. Nisin would be used

*: Delves-Broughton, J. (2005) Nisin as a food preservative. Food Australia, 57(12):525-527.

Known Regulations

Nisin is currently recognized as a safe food preservative in approximately 50 countries.

Nisin is the only lantibiotic allowed as a food supplement. In 1969 the FAO/WHO Expert Committee on Food Additives stated nisin to be safe and natural food additive (FAO/WHO, 1969).

Some fifteen years later nisin was commercially used in at least 39 countries (Hurst, 1983). In 1983 nisin was incorporated to the EEC food additive list and given the designation E234 (EEC, 1983). In the US, the Food and Drug Agency gave nisin a GRAS status (Generally Regarded As Safe) in 1988 (Federal Register, 1988). By the year 1996 nisin was allowed as a food additive in more than 50 countries, including the EU, China, and the US (Delves-Broughton et al. 1996).

The concerned part on nisin from U. S. CFR - Code of Federal Regulations Title 21. is incorporated here: PART 184, Subpart B, Sec. 184.1538 Nisin preparation.

(a) Nisin preparation is derived from pure culture fermentations of certain strains of Streptococcus lactis Lancefield Group N. Nisin preparation contains nisin (CAS Reg. No. 1414-45-5), a group of related peptides with antibiotic activity.

(b) The ingredient is a concentrate or dry material that meets the specifications.

? (1) Nisin content, not less than 900 international units per milligram.

? (2) Arsenic, not more than 1 part per million.

? (3) Lead, not more than 2 parts per million.

? (4) Zinc, not more than 25 parts per million.

? (5) Copper, zinc plus copper not more than 50 parts per million.

? (6) Total plate count, not more than 10 per gram.

? (7) Escherichia coli, absent in 10 grams.

? (8) Salmonella, absent in 10 grams.

? (9) Coagulase positive staphylococci, absent in 10 grams.

Glipid Indication, Action Of Glipid, Interactions, Glipid

Glipid [in more detail]

Glipid Indication:

For use as an adjunct to diet for the control of hyperglycemia and its associated symptomatology in patients with non-insulin-dependent diabetes mellitus (NIDDM; type II), formerly known as maturity-onset diabetes, after an adequate trial of dietary therapy has proved unsatisfactory.

Glipid Mechanism Of Action:

Sulfonylureas likely bind to ATP-sensitive potassium-channel receptors on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Depolarization stimulates calcium ion influx through voltage-sensitive calcium channels, raising intracellular concentrations of calcium ions, which induces the secretion, or exocytosis, of insulin.

Glipid Drug Interactions:

Food Interactions:

Avoid alcohol. Avoid sugar and sugary food. Take 30-60 minutes before breakfast.

Cetafrin, Cetafrin

Why register with MediGuard?

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Nostrilla 12 Hour (Oxymetazoline)

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Share your story! Tell us how MediGuard has helped you or someone you love. Download the MediGuard Mobile App to manage your prescription and over-the-counter medications, for free. Taking multiple medications puts you at risk for possible drug-drug interactions Monitor the medical treatment of you and your loved ones.

DISCLAIMER: MediGuard is not intended to be a substitute for professional medical advice. MediGuard cannot and does not take into consideration every possible interaction or account for individual responses to medicine. Different individuals may respond to medication in different ways. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective, or appropriate for any given patient. Always seek the advice of a qualified health provider with any questions you may have before making any changes to your treatment. The use of the MediGuard site and its content is at your own risk. The MediGuard site and the information contained in it is intended for users in the United States and information in other countries may be different.

© Quintiles 2016

Buy Frisolona Forte - Online Without Prescriptions, Frisolona Forte

Prednisolone (Frisolona forte)

Prednisolone is used for treating allergies, arthritis, breathing problems (eg, asthma), certain blood disorders, collagen diseases (eg, lupus), certain eye diseases (eg, keratitis), cancer (eg, leukemia), endocrine problems (eg, adrenocortical insufficiency), intestinal problems (eg, ulcerative colitis), swelling due to certain conditions, or skin conditions (eg, psoriasis). Prednisolone is a corticosteroid. It works by modifying the body's immune response to various conditions and decreasing inflammation.

Use Prednisolone as directed by your doctor.

Take Prednisolone by mouth with food.

If you miss a dose of Prednisolone, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Prednisolone.

Store Prednisolone at room temperature, between 68 and 77 degrees F (20 and 25 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Prednisolone out of the reach of children and away from pets.

Do NOT use Prednisolone if:

you are allergic to any ingredient in Prednisolone

you have a systemic fungal infection, a certain type of malaria, inflammation of the optic nerve, or herpes infection of the eye

you are scheduled to have a live or attenuated live vaccination (eg, smallpox)

you are taking mifepristone.

Contact your doctor right away if any of these apply to you.

Some medical conditions may interact with Prednisolone. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of heart problems (eg, congestive heart failure), heart attack, high blood pressure, kidney problems, liver problems, diabetes, seizures, an underactive thyroid, adrenal gland problems, fluid retention (eg, swelling of the hands, ankles, or feet), or any mental or mood problems

if you have or have recently had a fungal, bacterial, viral, or other type of infection; herpes infection of the eye; chickenpox; measles; or shingles

if you have HIV infection or tuberculosis (TB) infection, or if you have had ever had a positive TB skin test

if you have any stomach problems (eg, ulcers), intestinal problems (eg, blockage, perforation, or infection; unexplained diarrhea; diverticulitis; ulcerative colitis), recent intestinal surgery, or inflammation of the esophagus

if you have weak bones (eg, osteoporosis) or muscle problems (eg, myasthenia gravis)

if you have had a recent vaccination (eg, smallpox).

Some medicines may interact with Prednisolone. Tell your health care provider if you are taking any other medicines, especially any of the following:

Clarithromycin, cyclosporine, estrogens (eg, estradiol), oral contraceptives (eg, birth control pills), or ketoconazole because they may increase the risk of Prednisolone's side effects

Barbiturates (eg, phenobarbital), carbamazepine, ephedrine, hydantoins (eg, phenytoin), or rifampin because they may decrease Prednisolone's effectiveness

Anticholinesterases (eg, pyridostigmine), aspirin, diuretics (eg, hydrochlorothiazide, furosemide), methotrexate, mifepristone, quinolone antibiotics (eg, ciprofloxacin), ritodrine, or live or attenuated live vaccines because the risk of their side effects may be increased by Prednisolone

Anticoagulants (eg, warfarin), hydantoins (eg, phenytoin), or killed or inactivated vaccines because their effectiveness may be decreased by Prednisolone.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Prednisolone may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Avoid alcohol while you are using Prednisolone.

Prednisolone may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.

If you have not had chickenpox, shingles, or measles, avoid contact with anyone who does.

If you are taking Prednisolone regularly over a long period of time, carry an ID card at all times that says you take Prednisolone.

Do not receive a live vaccine (eg, measles, mumps, smallpox) while you are taking Prednisolone. Talk with your doctor before you receive any vaccine.

Tell your doctor or dentist that you take Prednisolone before you receive any medical or dental care, emergency care, or surgery.

Diabetes patients - Prednisolone may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

Lab tests, including adrenal function tests, may be performed while you use Prednisolone. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Caution is advised when using Prednisolone in children; they may be more sensitive to its effects.

Corticosteroids may affect growth rate in children and teenagers in some cases. They may need regular growth checks while they take Prednisolone.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Prednisolone while you are pregnant. Prednisolone is found in breast milk. If you are or will be breast-feeding while you use Prednisolone, check with your doctor. Discuss any possible risks to your baby.

If you are on long-term or high dosage therapy and you suddenly stop taking Prednisolone, you may have withdrawal symptoms, including fever, vomiting, appetite loss, diarrhea, nausea, dizziness, weight loss, weakness, general body discomfort, joint or muscle pain.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Acne; clumsiness; dizziness; facial flushing; feeling of a whirling motion; general body discomfort; headache; increased appetite; increased sweating; nausea; nervousness; sleeplessness; upset stomach.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; changes in body fat; changes in menstrual period; changes in skin color; chest pain; easy bruising or bleeding; increased hunger, thirst, or urination; mental or mood changes (eg, depression); muscle pain, weakness, or wasting; seizures; severe nausea or vomiting; shortness of breath; signs of infection (eg, fever, chills, persistent sore throat); sudden severe dizziness or headache; swelling of ankles, feet, or hands; tendon or bone pain; thinning of skin; unusual skin sensation; unusual weight gain; vision changes or other eye problems; vomit that looks like coffee grounds.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Customers who bought this product also bought

Prednisolone (Frisolona forte)

Prednisolone is used for treating allergies, arthritis, breathing problems (eg, asthma), certain blood disorders, collagen diseases (eg, lupus), certain eye diseases (eg, keratitis), cancer (eg, leukemia), endocrine problems (eg, adrenocortical insufficiency), intestinal problems (eg, ulcerative colitis), swelling due to certain conditions, or skin conditions (eg, psoriasis). Prednisolone is a corticosteroid. It works by modifying the body's immune response to various conditions and decreasing inflammation.

Use Prednisolone as directed by your doctor.

Take Prednisolone by mouth with food.

If you miss a dose of Prednisolone, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Prednisolone.

Store Prednisolone at room temperature, between 68 and 77 degrees F (20 and 25 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Prednisolone out of the reach of children and away from pets.

Do NOT use Prednisolone if:

you are allergic to any ingredient in Prednisolone

you have a systemic fungal infection, a certain type of malaria, inflammation of the optic nerve, or herpes infection of the eye

you are scheduled to have a live or attenuated live vaccination (eg, smallpox)

you are taking mifepristone.

Contact your doctor right away if any of these apply to you.

Some medical conditions may interact with Prednisolone. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of heart problems (eg, congestive heart failure), heart attack, high blood pressure, kidney problems, liver problems, diabetes, seizures, an underactive thyroid, adrenal gland problems, fluid retention (eg, swelling of the hands, ankles, or feet), or any mental or mood problems

if you have or have recently had a fungal, bacterial, viral, or other type of infection; herpes infection of the eye; chickenpox; measles; or shingles

if you have HIV infection or tuberculosis (TB) infection, or if you have had ever had a positive TB skin test

if you have any stomach problems (eg, ulcers), intestinal problems (eg, blockage, perforation, or infection; unexplained diarrhea; diverticulitis; ulcerative colitis), recent intestinal surgery, or inflammation of the esophagus

if you have weak bones (eg, osteoporosis) or muscle problems (eg, myasthenia gravis)

if you have had a recent vaccination (eg, smallpox).

Some medicines may interact with Prednisolone. Tell your health care provider if you are taking any other medicines, especially any of the following:

Clarithromycin, cyclosporine, estrogens (eg, estradiol), oral contraceptives (eg, birth control pills), or ketoconazole because they may increase the risk of Prednisolone's side effects

Barbiturates (eg, phenobarbital), carbamazepine, ephedrine, hydantoins (eg, phenytoin), or rifampin because they may decrease Prednisolone's effectiveness

Anticholinesterases (eg, pyridostigmine), aspirin, diuretics (eg, hydrochlorothiazide, furosemide), methotrexate, mifepristone, quinolone antibiotics (eg, ciprofloxacin), ritodrine, or live or attenuated live vaccines because the risk of their side effects may be increased by Prednisolone

Anticoagulants (eg, warfarin), hydantoins (eg, phenytoin), or killed or inactivated vaccines because their effectiveness may be decreased by Prednisolone.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Prednisolone may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Avoid alcohol while you are using Prednisolone.

Prednisolone may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.

If you have not had chickenpox, shingles, or measles, avoid contact with anyone who does.

If you are taking Prednisolone regularly over a long period of time, carry an ID card at all times that says you take Prednisolone.

Do not receive a live vaccine (eg, measles, mumps, smallpox) while you are taking Prednisolone. Talk with your doctor before you receive any vaccine.

Tell your doctor or dentist that you take Prednisolone before you receive any medical or dental care, emergency care, or surgery.

Diabetes patients - Prednisolone may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

Lab tests, including adrenal function tests, may be performed while you use Prednisolone. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Caution is advised when using Prednisolone in children; they may be more sensitive to its effects.

Corticosteroids may affect growth rate in children and teenagers in some cases. They may need regular growth checks while they take Prednisolone.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Prednisolone while you are pregnant. Prednisolone is found in breast milk. If you are or will be breast-feeding while you use Prednisolone, check with your doctor. Discuss any possible risks to your baby.

If you are on long-term or high dosage therapy and you suddenly stop taking Prednisolone, you may have withdrawal symptoms, including fever, vomiting, appetite loss, diarrhea, nausea, dizziness, weight loss, weakness, general body discomfort, joint or muscle pain.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Acne; clumsiness; dizziness; facial flushing; feeling of a whirling motion; general body discomfort; headache; increased appetite; increased sweating; nausea; nervousness; sleeplessness; upset stomach.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; changes in body fat; changes in menstrual period; changes in skin color; chest pain; easy bruising or bleeding; increased hunger, thirst, or urination; mental or mood changes (eg, depression); muscle pain, weakness, or wasting; seizures; severe nausea or vomiting; shortness of breath; signs of infection (eg, fever, chills, persistent sore throat); sudden severe dizziness or headache; swelling of ankles, feet, or hands; tendon or bone pain; thinning of skin; unusual skin sensation; unusual weight gain; vision changes or other eye problems; vomit that looks like coffee grounds.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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