Aklav, Aklav

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Our company, Aklav – Equestrian Obstacles offers a wide variety of show jumping course obstacles, training obstacles and separate parkour elements such as parkour stands, bars, wall bases, posts and rails, planks, cavaletti and advertising banners.

Our products are made from high quality materials to provide durability and safety. Quality and attention to details distinguish our company from the competition. We produce and customize whole parkours as well as separate obstacles.

We guarantee an individual approach to every client.

We look forward to doing business with you in the future!

Metformin Side Effects In Detail, Metformine

Metformin Side Effects

In Summary

Commonly reported side effects of metformin include: lactic acidosis, diarrhea, nausea, vomiting, nausea and vomiting, and flatulence. Other side effects include: diarrhea, nausea, vomiting, decreased vitamin b12 serum concentrate, and weakness. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to metformin: oral solution, oral tablet, oral tablet extended release

In addition to its needed effects, some unwanted effects may be caused by metformin. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking metformin:

More common:

Abdominal or stomach discomfort

cough or hoarseness

decreased appetite

diarrhea

fast or shallow breathing

fever or chills

general feeling of discomfort

lower back or side pain

muscle pain or cramping

painful or difficult urination

sleepiness

Less common:

Anxiety

blurred vision

chest discomfort

cold sweats

coma

confusion

cool, pale skin

depression

difficult or labored breathing

dizziness

fast, irregular, pounding, or racing heartbeat or pulse

feeling of warmth

headache

increased hunger

increased sweating

nausea

nervousness

nightmares

redness of the face, neck, arms, and occasionally, upper chest

seizures

shakiness

shortness of breath

slurred speech

tightness in the chest

unusual tiredness or weakness

wheezing

Rare

Behavior change similar to being drunk

difficulty with concentrating

drowsiness

lack or loss of strength

restless sleep

unusual sleepiness

Minor Side Effects

Some of the side effects that can occur with metformin may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:

Acid or sour stomach

belching

bloated

excess air or gas in the stomach or intestines

full feeling

heartburn

indigestion

loss of appetite

metallic taste in the mouth

passing of gas

stomachache

stomach upset or pain

vomiting

weight loss

Less common:

Abnormal stools

bad, unusual, or unpleasant (after) taste

change in taste

difficulty with moving

discoloration of the fingernails or toenails

flu-like symptoms

joint pain

rash

runny nose

sneezing

stuffy nose

swollen joints

For Healthcare Professionals

Applies to metformin: compounding powder, oral solution, oral tablet, oral tablet extended release

General

Gastrointestinal events such as nausea, vomiting, diarrhea, abdominal pain, and loss of appetite have been frequently reported during therapy initiation and resolve spontaneously in most cases.

Adverse events in the pediatric population appear to be similar in nature and severity to that published in adults. [Ref ]

Metabolic

Common (1% to 10%): Hypoglycemia Very rare (less than 0.01%): Lactic acidosis [Ref ]

Gastrointestinal

Very common (10% or more): Diarrhea (53.2%), nausea/vomiting (25.5%), flatulence (12.1%) Common (1% to 10%): Indigestion, abdominal discomfort, abnormal stools, dyspepsia, loss of appetite [Ref ]

Hematologic

Very rare (less than 0.01%): Subnormal vitamin B12 levels [Ref ]

Other

Common (1% to 10%): Asthenia, chills, flu syndrome, accidental injury [Ref ]

Hepatic

Very rare (less than 0.01%): Liver function test abnormalities, hepatitis [Ref ]

Cardiovascular

Common (1% to 10%): Chest discomfort, flushing, palpitation [Ref ]

Dermatologic

Common (1% to 10%): Rash, nail disorder, increased sweating Very rare (less than 0.01%): Erythema, pruritus, urticaria [Ref ]

Endocrine

Frequency not reported: Reduction in thyrotropin (TSH) levels [Ref ]

Immunologic

Very common (10% or more): Infection (20.5%) [Ref ]

Musculoskeletal

Common (1% to 10%): Myalgia [Ref ]

Nervous system

Common (1% to 10%): Lightheadedness, taste disturbances [Ref ]

Psychiatric

Common (1% to 10%): Headache [Ref ]

Respiratory

Common (1% to 10%): Rhinitis [Ref ]

References

1. "Product Information. Glucophage (metformin)." Bristol-Myers Squibb, Princeton, NJ.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. "Product Information. Fortamet (metFORMIN)." Physicians Total Care, Tulsa, OK.

4. Cerner Multum, Inc. "Australian Product Information." O 0

5. "Product Information. Riomet (metFORMIN)." Ranbaxy Pharmaceuticals, Jacksonville, FL.

6. "Product Information. Glumetza (metFORMIN)." Biovail Pharmaceuticals Canada, Mississauga, IA.

Not all side effects for metformin may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here .

More about metformin

Consumer resources

Professional resources

Related treatment guides

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. The information is not a substitute for the knowledge and judgement of a healthcare professional. Always consult with your doctor, nurse, or pharmacist before taking medication.

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Buy Dix-Tr - Diclofenac - Online Without Prescriptions, Dix-Tr

Diclofenac (Dix-tr)

Diclofenac is used primarily for the treatment of inflammation and pain caused by conditions such as rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. It is also effective in treating soft tissue inflammations due to tendinitis and bursitis, and treating dysmenorrhea (menstrual cramps). Diclofenac is an NSAID. NSAIDs treat the symptoms of pain and inflammation. They do not treat the disease that causes those symptoms.

Use Diclofenac as directed by your doctor!

Take Diclofenac by mouth. It may be taken with food if it upsets your stomach. Taking it with food may not lower the risk of stomach or bowel problems (eg, bleeding, ulcers). Talk with your doctor or pharmacist if you have persistent stomach upset.

Take Diclofenac with a full glass of water (8 oz/240 mL) as directed by your doctor.

If you miss a dose of Diclofenac, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Diclofenac.

Store Diclofenac at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Diclofenac out of the reach of children and away from pets.

Do NOT use Diclofenac if:

you are allergic to any ingredient in Diclofenac or to bovine (cow) protein

you have had a severe allergic reaction (eg, severe rash, hives, trouble breathing, growths in the nose, dizziness) to aspirin or an NSAID (eg, ibuprofen, celecoxib)

you have recently had or will be having bypass heart surgery

you have severe kidney problems

you are in the last 3 months of pregnancy.

Contact your doctor or health care provider right away if this applies to you.

Some medical conditions may interact with Diclofenac. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of kidney or liver problems, diabetes, or stomach or bowel problems (eg, bleeding, perforation, ulcers)

if you have a history of swelling or fluid buildup, asthma, growths in the nose (nasal polyps), or mouth inflammation

if you have high blood pressure, blood disorders (eg, porphyria), bleeding or clotting problems, heart problems (eg, heart failure), or blood vessel disease, or if you are at risk for any of these diseases

if you have poor health, dehydration or low fluid volume, or low blood sodium levels, you smoke, drink alcohol, or have a history of alcohol abuse

if you are taking an antibiotic or an anti-seizure medicine. The risk of liver problems may be increased with some of these medicines.

Some medicines may interact with Diclofenac. Tell your health care provider if you are taking any other medicines, especially any of the following:

Anticoagulants (eg, warfarin), aspirin, clopidogrel, corticosteroids (eg, prednisone), heparin and other blood thinners (eg, dalteparin), or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) because the risk of stomach bleeding may be increased

Acetaminophen because the risk of liver problems may be increased

Probenecid because it may increase the risk of Diclofenac's side effects

Cyclosporine, lithium, metformin, methotrexate, oral NSAIDs (eg, ibuprofen), or quinolones (eg, ciprofloxacin) because the risk of their side effects may be increased by Diclofenac

Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril) or diuretics (eg, furosemide, hydrochlorothiazide) because their effectiveness may be decreased by Diclofenac.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Diclofenac may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Diclofenac may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Diclofenac with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Serious stomach ulcers or bleeding can occur with the use of Diclofenac. Taking it in high doses, for a long time, smoking, or drinking alcohol increases the risk of these side effects. Taking Diclofenac with food will NOT reduce the risk of these effects. If you have severe stomach or back pain; black, tarry stools; vomit that looks like blood or coffee grounds; or unusual weight gain or swelling, contact your doctor or emergency room right away.

Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.

Diclofenac is an NSAID. Before you start any new medicine, check the label to see if it has an NSAID (eg, ibuprofen) in it too. If it does or if you are not sure, check with your doctor or pharmacist.

Do not take aspirin while you are using Diclofenac unless your doctor tells you to.

Check with your doctor or pharmacist before you take acetaminophen while you are taking Diclofenac. The risk of liver problems may be increased.

Do not switch between different forms of Diclofenac (eg, enteric-coated tablets, immediate-release tablets, capsules) unless your doctor tells you to. They may not provide the same amount of medicine to your body.

Lab tests, including kidney function, liver function, blood electrolyte levels, complete blood cell counts, and blood pressure, may be performed while you use Diclofenac. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Diclofenac with caution in the elderly; they may be more sensitive to its effects, especially stomach bleeding and kidney problems.

Diclofenac should be used with extreme caution in children; safety and effectiveness in children have not been confirmed.

Pregnancy and breast-feeding: Diclofenac may cause harm to the fetus. Do not use it during the last 3 months of pregnancy. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Diclofenac while you are pregnant. It is not known if Diclofenac is found in breast milk. Do not breastfeed while taking Diclofenac.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Constipation; diarrhea; dizziness; drowsiness; headache; mild stomach pain or heartburn; nausea; vomiting.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; trouble breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody or black, tarry stools; change in the amount of urine produced; chest pain; confusion; depression; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; mental or mood changes; numbness of an arm or leg; one-sided weakness; persistent flu-like symptoms; red, swollen, blistered, or peeling skin; ringing in the ears; seizures; severe headache or dizziness; severe or persistent stomach pain or nausea; severe vomiting or diarrhea; shortness of breath; sudden or unexplained weight gain; swelling of the hands, legs, or feet; symptoms of liver problems (eg, dark urine, pale stools, persistent loss of appetite, yellowing of the skin or eyes); unusual bruising or bleeding; unusual joint or muscle pain; unusual tiredness or weakness; vision or speech changes; vomit that looks like coffee grounds.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Spatanil, Spatanil

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Zyrtec (Cetirizine)

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DISCLAIMER: MediGuard is not intended to be a substitute for professional medical advice. MediGuard cannot and does not take into consideration every possible interaction or account for individual responses to medicine. Different individuals may respond to medication in different ways. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective, or appropriate for any given patient. Always seek the advice of a qualified health provider with any questions you may have before making any changes to your treatment. The use of the MediGuard site and its content is at your own risk. The MediGuard site and the information contained in it is intended for users in the United States and information in other countries may be different.

© Quintiles 2016

Zyrtec (cetirizine) is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Zyrtec is used to treat cold or allergy symptoms such as sneezing, itching, watery eyes, or runny nose.

Zyrtec is also used to treat itching and swelling caused by chronic urticaria (hives).

Zyrtec may also be used for purposes not listed in this medication guide.

Use Zyrtec exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

You may take Zyrtec with or without food.

The chewable tablet must be chewed before you swallow it.

Do not swallow the Zyrtec dissolving tablet whole. Allow it to dissolve in your mouth without chewing. Swallow several times as the tablet dissolves. If desired, you may drink liquid to help swallow the dissolved tablet.

Call your doctor if your symptoms do not improve, if they get worse, or if you also have a fever. Store this medicine at room temperature away from moisture and heat. Do not allow the liquid form of this medicine to freeze.

Use Zyrtec exactly as directed on the label, or as prescribed by your doctor.

Ask your health care provider any questions you may have about how to use Zyrtec.

Store at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture. Brief storage between 59-86 degrees F (15-30 degrees C) is permitted. Or store in the refrigerator between 36-46 degrees F (2-8 degrees C). Do not store in the bathroom. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Active ingredient: Cetirizine

Inactive ingredients: colloidal silicon dioxide, croscarmellose sodium, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, polyethylene glycol, titanium dioxide

Do NOT use Zyrtec if:

You are allergic to any ingredient in Zyrtec or to hydroxyzine Contact your doctor or health care provider right away if any of these apply to you. Some medical conditions may interact with Zyrtec. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you: if you are pregnant, plan to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have kidney or liver problems, or are receiving dialysis

Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Zyrtec ; it may add to their effects.

Ask a doctor or pharmacist if it is safe for you to take this medicine if you have any medical conditions.

Tell your doctor if you regularly use other medicines that make you sleepy (such as other cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by Zyrtec.

This list is not complete and other drugs may interact with Zyrtec. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Important safety information:

Do not use with any other antihistamines applied to the skin (such as diphenhydramine cream, ointment, spray) because increased side effects may occur.

If you are scheduled for allergy testing, ask your doctor if you should stop taking this medication for several days before testing. This drug may affect your allergy test results.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and health care provider.

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Zyrtec:

Drowsiness; dry mouth; stomach pain (in children); tiredness; trouble sleeping (in children).

Seek medical attention right away if any of these SEVERE side effects occur when using Zyrtec:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); dark urine; fainting; fast or irregular heartbeat; mental or mood changes; persistent fatigue; seizures; severe dizziness; unusual bruising or bleeding; yellowing of eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects.

Zyrtec (cetirizine) is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Zyrtec is used to treat cold or allergy symptoms such as sneezing, itching, watery eyes, or runny nose.

Zyrtec is also used to treat itching and swelling caused by chronic urticaria (hives).

Zyrtec may also be used for purposes not listed in this medication guide.

Use Zyrtec exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

You may take Zyrtec with or without food.

The chewable tablet must be chewed before you swallow it.

Do not swallow the Zyrtec dissolving tablet whole. Allow it to dissolve in your mouth without chewing. Swallow several times as the tablet dissolves. If desired, you may drink liquid to help swallow the dissolved tablet.

Call your doctor if your symptoms do not improve, if they get worse, or if you also have a fever. Store this medicine at room temperature away from moisture and heat. Do not allow the liquid form of this medicine to freeze.

Use Zyrtec exactly as directed on the label, or as prescribed by your doctor.

Ask your health care provider any questions you may have about how to use Zyrtec.

Store at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture. Brief storage between 59-86 degrees F (15-30 degrees C) is permitted. Or store in the refrigerator between 36-46 degrees F (2-8 degrees C). Do not store in the bathroom. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Active ingredient: Cetirizine

Inactive ingredients: colloidal silicon dioxide, croscarmellose sodium, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, polyethylene glycol, titanium dioxide

Do NOT use Zyrtec if:

You are allergic to any ingredient in Zyrtec or to hydroxyzine Contact your doctor or health care provider right away if any of these apply to you. Some medical conditions may interact with Zyrtec. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you: if you are pregnant, plan to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have kidney or liver problems, or are receiving dialysis

Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Zyrtec ; it may add to their effects.

Ask a doctor or pharmacist if it is safe for you to take this medicine if you have any medical conditions.

Tell your doctor if you regularly use other medicines that make you sleepy (such as other cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by Zyrtec.

This list is not complete and other drugs may interact with Zyrtec. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Important safety information:

Do not use with any other antihistamines applied to the skin (such as diphenhydramine cream, ointment, spray) because increased side effects may occur.

If you are scheduled for allergy testing, ask your doctor if you should stop taking this medication for several days before testing. This drug may affect your allergy test results.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and health care provider.

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Zyrtec:

Drowsiness; dry mouth; stomach pain (in children); tiredness; trouble sleeping (in children).

Seek medical attention right away if any of these SEVERE side effects occur when using Zyrtec:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); dark urine; fainting; fast or irregular heartbeat; mental or mood changes; persistent fatigue; seizures; severe dizziness; unusual bruising or bleeding; yellowing of eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects.

Bactoderm For Animal Use, Bactoderm

Bactoderm

This page contains information on Bactoderm for veterinary use . The information provided typically includes the following:

Bactoderm Indications

Warnings and cautions for Bactoderm

Direction and dosage information for Bactoderm

Bactoderm

This treatment applies to the following species:

Dogs

Manufacturer: Pfizer Animal Health

For dermatologic use on dogs

Bactoderm Caution

Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Description

Each gram of Bactoderm ointment contains 20 mg of mupirocin in a bland, water-washable ointment base consisting of polyethylene glycol 400 and polyethylene glycol 3350 (polyethylene glycol ointment, NF). Mupirocin is a naturally-occurring, broad-spectrum antibiotic. The chemical name is 9 - 4 - [5S - (2S,3S - epoxy - 5S - hydroxy - 4S - methylhexyl) - 3R,4R - dihydroxytetrahydropyran - 2S - yl] - 3 - methylbut - 2(E) - enoyloxy - nonanoic acid. The chemical structure is:

Clinical Pharmacology

Mupirocin is a chemical entity produced by fermentation of the organism Pseudomonas fluorescens. Mupirocin inhibits bacterial protein synthesis by reversibly and specifically binding to bacterial isoleucyl transfer-RNA synthetase. Due to this mode of action, mupirocin shows no cross resistance with chloramphenicol, erythromycin, gentamicin, lincomycin, neomycin, novobiocin, penicillin, streptomycin, and tetracycline. Mupirocin is an antimicrobial agent that inhibits the growth of gram-positive and gram-negative bacteria.

Bacteria susceptible to the action of mupirocin in vitro include the aerobic isolates of Staphylococcus aureus (including methicillin-resistant strains and β-lactamase-producing strains), Staphylococcus intermedius, Staphylococcus epidermidis, other coagulase positive or negative Staphylococci, α-hemolytic Streptococci, β group A Streptococci (including S. pyogenes), other β Streptococci (including S. agalactiae), group D Streptococci (including S. faecalis and S. faecium), group Viridans Streptococci, Streptococcus pneumoniae, Corynebacterium hofmanii, Bacillus subtilis, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Proteus vulgaris, Enterobacter cloacae, Enterobacter aerogenes, Citrobacter freundii, Hemophilus influenzae (including β-lactamase-producing strains), Neisseria gonorrheae (including β-lactamase-producing strains), Neisseria meningitidis, Branhamella catarrhalis and Pasteurella multocida, and the anaerobic isolates of Peptostreptococcus anaerobius, Clostridium difficile, and Clostridium sporogenes.

Clinical significance of the in vitro data is unknown except for susceptible strains of Staphylococcus aureus and Staphylococcus intermedius.

Bactoderm Indications For Use

Bactoderm ointment is indicated for the topical treatment of canine bacterial infections of the skin, including superficial pyoderma, caused by susceptible strains of Staphylococcus aureus and Staphylococcus intermedius.

Contraindications

This drug is contraindicated in animals with a history of sensitivity reactions to any of its components.

Warnings

Because of the potential hazard of nephrotoxicity due to the polyethylene glycol content of the base, care should be exercised when using this product in treating extensive deep lesions where absorption of large quantities of polyethylene glycol is possible.

Safety of use in pregnant or breeding animals has not been determined.

Bactoderm ointment is not for ophthalmic use.

Adverse Reactions

No adverse reactions have been reported with this product. If a skin reaction such as irritation should occur, treatment should be discontinued and appropriate therapy instituted.

Bactoderm Dosage And Administration

Prior to treatment, the lesion should be cleansed. Bactoderm ointment should be applied to the affected area twice a day. Apply a sufficient amount of ointment to completely cover the infected area. Maximum duration of treatment should not exceed 30 days.

How Supplied

Bactoderm ointment is supplied in 15-gram tubes.

Store Between 15° And 30°c (59° And 86°f)

Keep Out Of Reach Of Children

NADA #140-839, Approved by FDA

Manufactured by: SmithKline Beecham Pharmaceuticals, Philadelphia, PA 19101

Distributed by: Pfizer Animal Health, Exton, PA 19341, USA, Div. of Pfizer Inc, NY, NY 10017

Pinaclor, Pinaclor

Pinaclor - (Cefaclor)

Pinaclor capsules and oral suspension contain the active ingredient cefaclor, which is a type of medicine called an antibiotic. Pinaclor is a type of antibiotic called a cephalosporin. These antibiotics are related to penicillin. Pinaclor is used to treat infections wih bacteria.

How does Pinaclor work?

Pinaclor works by interfering with the ability of bacteria to form cell walls. The cell walls of bacteria are vital for their survival. They keep unwanted substances from entering their cells and stop the contents of their cells from leaking out. Pinaclor impairs the bonds that hold the bacterial cell wall together. This allows holes to appear in the cell walls and kills the bacteria.

Pinaclor is a broad-spectrum antibiotic that kills a wide variety of bacteria that cause a wide variety of commonly-occuring infections. Pinaclor is given by mouth to treat infections of the upper and lower airways, ears, skin and soft tissue.

It may also be used to treat urinary tract infections.

To make sure the bacteria causing an infection are susceptible to cefaclor your doctor may take a tissue sample, for example a swab from the throat or skin, or a urine or blood sample.

What is Pinaclor used for?

Bacterial infections of the lungs and airways, including nasal passages, sinuses and windpipe (respiratory tract), eg sinusitis, bronchitis , pneumonia .

Bacterial infections of the ears, nose or throat, eg otitis media, pharyngitis, tonsillitis.

Bacterial infections of the skin or soft tissue, eg abscesses, cellulitis, mastitis, erysipelas.

Bacterial infections of the kidneys (pyelonephritis).

Bacterial infections of the urinary tract .

How do I take Pinaclor?

The dose of this medicine and how long it needs to be taken for depends on the type of infection you have, your age and your kidney function. Follow the instructions given by your doctor. These will be printed on the dispensing label that your pharmacist has put on the packet of medicine.

Pinaclor can be taken either with or without food. You should try to space the doses evenly throughout the day.

The capsules should be swallowed with liquid.

Bottles of suspension should be shaken before measuring out a dose. Only use the measuring spoon provided with the suspension. You should not use a regular teaspoon or tablespoon to take the medicine, as this will not give an accurate dose.

Unless your doctor tells you otherwise, it is important that you finish the prescribed course of this antibiotic medicine, even if you feel better or it seems the infection has cleared up. Stopping the course early increases the chance that the infection will come back and that the bacteria will grow resistant to the antibiotic .

Side Effects of Pinaclor:

Gastro?intestinal: The most frequent side?effect has been diarrhoea. It is rarely severe enough to warrant cessation of therapy. Colitis, including rare instances of pseudomembranous colitis, has been reported. Nausea and vomiting have also occurred.

Hypersensitivity: Allergic reactions such as morbilliform eruptions, pruritus and urticaria have been observed. These reactions usually subside upon discontinuation of therapy. Serum sickness?like reactions (erythema multiforme minor, rashes or other skin manifestations accompanied by arthritis /arthralgia, with or without fever) have been reported. Lymphadenopathy and proteinuria are infrequent; there are no circulating immune complexes and no evidence of sequelae. Occasionally, solitary symptoms may occur, but do not represent a serum sickness?like reaction. Serum sickness?like reactions are apparently due to hypersensitivity and have usually occurred during or following a second (or subsequent) course of therapy with cefaclor. Such reactions have been reported more frequently in children than in adults. Signs and symptoms usually occur a few days after initiation of therapy and usually subside within a few days of cessation of therapy. Antihistamines and corticosteroids appear to enhance resolution of the syndrome. No serious sequelae have been reported.

There are rare reports of erythema multiforme major (Stevens?Johnson syndrome), toxic epidermal necrolysis, and anaphylaxis. Anaphylaxis may be more common in patients with a history of penicillin allergy. Anaphylactoid events may present as solitary symptoms, including angioedema, asthenia, oedema (including face and limbs), dyspnoea, paraesthesias, syncope, or vasodilatation.

Rarely, hypersensitivity symptoms may persist for several months.

Haematological: Eosinophilia, positive Coombs' tests and, rarely, thrombocytopenia. Transient lymphocytosis, leucopenia and, rarely, haemolytic anaemia, aplastic anaemia. agranulocytosis and reversible neutropenia of possible clinical significance. See 'Interactions with other medicaments and other forms of interaction'.

Hepatic: Transient hepatitis and cholestatic jaundice have been reported rarely, slight elevations in AST, ALT or alkaline phosphatase values.

Renal: Reversible interstitial nephritis has occurred rarely, also slight elevations in blood urea or serum creatinine or abnormal urinalysis.

Central nervous system: Reversible hyperactivity, agitation, nervousness, insomnia, confusion, hypertonia, dizziness, hallucinations and somnolence have been reported rarely.

Miscellaneous: Genital pruritus, vaginitis and vaginal moniliasis.

Pregnancy and breastfeeding

Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

This medicine is not known to be harmful when used by pregnant women. However, as with all medicines, it should be used with caution during pregnancy and only when considered essential by your doctor, particularly during the first trimester. Seek medical advice from your doctor.

This medicine passes into breast milk. It should be used with caution in breastfeeding mothers and only if the expected benefit to the mother is greater than any possible risk to the nursing infant. Seek medical advice from your doctor.

Storage:

Capsule: Store below 25°C. Keep containers tightly closed and protect from light.

Suspensions: Store at room temperature (15?25°C). Keep containers tightly closed and protect from light. After reconstitution, the suspension should be stored in a refrigerator (2?8°C) and be used within 14 days.

If you have any more questions please ask your Pharmacist.

Remember to keep all medicines out of reach of children

Please Note: We have made every effort to ensure that the content of this information sheet is correct at time of publish, but remember that information about drugs may change. This sheet does not list all the uses and side-effects associated with this drug. For full details please see the drug information leaflet which comes with your medicine. Your doctor will assess your medical circumstances and draw your attention to any information or side-effects which may be relevant in your particular case.

References:

Feature And Application, Duranol

Asahi Kasei's polycarbonatediol (PCD)

HOME > Feature and Application

Feature and Application

Introduction of polycarbonatediol (PCD)

PCD has a carbonate skeleton and is a long-chain diol having hydroxyl groups at its both ends. Generally, polyurethane using PCD offers excellent heat resistance, hydrolysis resistance, chemical resistance, weather resistance, and mechanical properties when compared to those using polyether polyol (PTMG) or polyester polyol (PHA/PCL).

PTMG:Polytetramethylene glycol(Polyether polyol) PHA:Poly1,6-hexamethylene adipate(Polyester polyol) PCL:Polycaprolactone polyol(Polyester polyol)

Feature of DURANOL™

Although PCD offers excellent durability, hydrolysis resistance, and chemical resistance when compared to other polyols, its flexibility is inferior to that of the polyols. Our PCD, DURANOL™ maintains the features of PCD as described above and has the following features when compared to PCD of homopolymer type due to its improved flexibility.

Ease of handling due to liquid state at room temperature T5652?T5651?T5650J?T5650E?G4672?T4671

Low crystallinity and high solubility to various solvents T5652?T5651?T5650J?T5650E

Excellemt chemical resistance and abrasion resistance G3452?G3450J?T4692?T4691

Major application of DURANOL™

DURANOL™ is suitable for applications that require durability in particular, such as leather (synthetic leather, artificial leather, etc.), paint, adhesive, and elastomer.

[Paint] Use of DURANOL™ allows you to obtain a polyurethane paint with excellent scratch resistance, chemical resistance, abrasion resistance, and weather resistance. Above all, liquid type DURANOL™ is amorphous and its stress at a low strain is smaller than that of solid type PCD, thus it can offer softer feeling as a binder of a soft feel paint. Additionally, its solubility to solvents is high and thus, for solvent paints, allows reduction of the amount of solvent used and higher solid content. Furthermore, for water-based paint, it disperses into water with a small amount of solvent (or without solvent) and thus allows environmentally friendly paint design. DURANOL™ is used in a wide range of fields such as automobile, home appliances, mobile devices, and general industries

[Leather] Use of DURANOL™ allows you to obtain a polyurethane resin with excellent hydrolysis resistance, moisture heat resistance, chemical resistance, and abrasion resistance, as well as to improve the durability of polyurethane resins for leather, such as a binder of synthetic leather/artificial leather and surface treatment agents for various leathers. DURANOL™ is used in a wide range of fields such as automobile, furniture, shoes, clothing, and sundry goods.

[Elastomer] Use of DURANOL™ allows you to obtain thermoplastic and thermoset elastomer and resin with excellent chemical resistance, abrasion resistance, and flexibility. DURANOL™ is used in a wide range of fields such as various rollers, rolls, belts, sealing, and gaskets.

[Adhesive] Use of DURANOL™ allows you to obtain a polyurethane adhesive with excellent moisture heat resistance, hydrolysis resistance, and flexibility. DURANOL™ is used in a wide range of fields such as various structural materials, electronic materials, and general industries.

Privacy Policy | Terms Conditions Copyright (C) Asahi Kasei Corporation. All rights reserved.

Phenergan - Sleep Aid, Synvomin

Product Description Common use Phenergan is an antihistamine used to treat different types of allergy symptoms, including itching, runny nose, sneezing, itchy or watery eyes, hives, and itchy skin rashes. It works by decreasing the effects of histamine, a chemical the body releases in response to certain irritants. Also Phenegran is used as a sedative and sleep aid for all types of patients and prevent or control nausea and vomiting, treat motion sickness. You can use it with other medications, for pain after surgery also.

Dosage and direction Take it orally with or without food/milk. It is better take this medication with food if you want to avoid stomach upset. For treating allergy the recommended dose is 25 mg before sleeping. You can repeat the dose within two hours if necessary. For treating motion sickness the recommended dose is 25 mg twice daily. Note: this instruction presented here just for review. It's very necessary to consult your doctor before using. It will help you to get better results.

Precautions Do not give this drug to patients in coma. Do not use alcohol while taking Phenergan because it can extreme drowsiness. Avoid alcohol use. Phenergan may increase sensitivity to sunlight. Wear a sunscreen and protective clothing when you are exposed to the sun, it'll help you to avoid a heat stroke. Phenergan should not be used during pregnancy, becoming pregnancy or lactating without telling your doctor. Do not use before breast-feeding without doctor's advice.

Contraindications Phenergan is not allowed to children under 2 years of age. Phenergan is contraindicated in comatose states, and in individuals known to be hypersensitive or to have had an idiosyncratic reaction to promethazine or to other phenothiazines. Also this drug is contraindicated for use in the treatment of lower respiratory tract symptoms including asthma.

Possible side effect They may include an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Also the most possible side effects include: twitching, or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs; tremor (uncontrolled shaking), drooling, trouble swallowing, problems with balance or walking; feeling restless, jittery, or agitated; high fever, stiff muscles, confusion, sweating, fast or uneven heartbeats, rapid breathing; feeling like you might pass out; seizure (convulsions); pale skin, easy bruising or bleeding, fever, sore throat, flu symptoms; decreased night vision, tunnel vision, watery eyes, increased sensitivity to light; hallucinations, agitation; nausea and stomach pain, skin rash, and jaundice (yellowing of the skin or eyes); urinating less than usual or not at all; joint pain or swelling with fever, swollen glands, muscle aches, chest pain, vomiting, unusual thoughts or behavior, and patchy skin color; or slow heart rate, weak pulse, fainting, slow breathing (breathing may stop).

Less serious include: dizziness, drowsiness, anxiety; blurred vision, dry mouth, stuffy nose; ringing in your ears; weight gain, swelling in your hands or feet; impotence, trouble having an orgasm; or constipation. If you experience one of them stop using Phenegran and tell your doctor as soon as possible. Also consult with your doctor about any side effect that seems unusual.

Drug interaction Phenergan interact with such drugs as: lithium (Eskalith, Lithobid); atropine (Atreza, Sal-Tropine), belladonna (Donnatal, and others), benztropine (Cogentin), dimenhydrinate (Dramamine), methscopolamine (Pamine), or scopolamine (Transderm-Scop); blood pressure medication such as guanadrel (Hylorel), guanethidine (Ismelin), propranolol (Inderal), and others; a blood thinner such as warfarin (Coumadin); bronchodilators such as ipratropium (Atrovent) or tiotropium (Spiriva); bladder or urinary medications such as oxybutynin (Ditropan, Oxytrol), solifenacin (Vesicare), and others; an MAO inhibitor such as isocarboxazid (Marplan), tranylcypromine (Parnate), phenelzine (Nardil), selegiline (Eldepryl, Emsam); medicines to treat Parkinson's disease, restless leg syndrome, or pituitary gland tumor (prolactinoma); medicine to treat stomach ulcer or irritable bowel syndrome, such as dicyclomine (Bentyl), glycopyrrolate (Robinul), hyoscyamine (Anaspaz, Cystospaz, Levsin, and others), mepenzolate (Cantil), or propantheline (Pro-Banthine). Also note that interaction between two medications does not always mean that you must stop taking one of them. As usual it affects the the effect of drugs, so consult with your doctor about how it interactions are being managed or should be managed.

Missed dose If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not take double or extra doses. Take your usually dose next day in the same regularly time.

Overdose Symptoms of Phenergan overdose may include: severe drowsiness, dizziness, dry mouth, large pupils, flushing, nausea, vomiting, shallow breathing, and fainting. If you experience one of them call your doctor immediately.

Storage Store at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture, kids and pets. Do not use after expiration term.

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Buy Naclodin Clonidine Online Without Prescriptions, Naclodin

Clonidine is used to treat hypertension (high blood pressure). It is sometimes used together with other blood pressure medications. Clonidine lowers blood pressure by decreasing the levels of certain chemicals in your blood. This allows your blood vessels to relax and your heart to beat more slowly and easily.

Use Clonidine as directed by your doctor.

Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the instructions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results from Clonidine.

Clonidine is usually taken in the morning and at bedtime. Follow your doctor's instructions.

If you need to have any type of surgery, tell the surgeon ahead of time that you are taking Clonidine. You may need to stop using the medicine for a short time. Do not stop taking this medication suddenly without first talking to your doctor. Stopping this medication suddenly can cause nervousness, agitation, headache, tremors, severe high blood pressure, or life-threatening symptoms. Talk with your doctor about how to avoid withdrawal symptoms when you stop taking Clonidine.

Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

If you miss a dose of Clonidine, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Clonidine.

Store Clonidine at 77 degrees F (25 degrees C) away from heat, moisture, and light. Do not store in the bathroom. Keep Clonidine out of the reach of children and away from pets.

Do NOT use Clonidine if:

you are allergic to any ingredient in Clonidine

you are pregnant, in labor, or about to begin labor

you have bleeding problems

you are taking an anticoagulant (eg, warfarin, heparin).

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Clonidine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have kidney problems, porphyria, or depression

if you have blood vessel disease affecting the brain or severe heart disease, or you have had a stroke or a recent heart attack

if you are scheduled for surgery.

Some medicines may interact with Clonidine. Tell your health care provider if you are taking any other medicines, especially any of the following:

Beta-blockers (eg, propranolol), calcium channel blockers (eg, verapamil), or digitalis because a severe decrease in heart rate may occur

Tricyclic antidepressants (eg, amitriptyline) because the effectiveness of Clonidine may be decreased and certain side effects may be increased

Anticoagulant therapy (eg, warfarin, heparin) because the risk of bleeding at the injection site may be increased.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Clonidine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Clonidine may cause drowsiness, dizziness, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Clonidine with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Clonidine; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.

Clonidine may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.

Do not suddenly stop taking Clonidine. Doing so may cause withdrawal symptoms like nervousness, irritability, or shakiness. You could also get a headache and high blood pressure. The risk of these effects may be greater if you have been taking high doses of Clonidine. The risk may also be greater if you are taking a beta-blocker (eg, atenolol). Rarely, very serious effects like increased blood pressure in the brain, stroke, or death have occurred. Check with your doctor before you change your dose or stop Clonidine.

If you experience dry mouth, use candy or gum, or melt bits of ice in your mouth.

Use Clonidine with caution in the elderly; they may be more sensitive to its effects, especially dizziness.

Clonidine should be used with extreme caution in children; safety and effectiveness in children have not been confirmed. Use is limited to patients old enough to tolerate placement and management of an epidural catheter.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Clonidine while you are pregnant. Clonidine is found in breast milk. If you are or will be breast-feeding while you use Clonidine, check with your doctor. Discuss any possible risks to your baby.

If you stop taking Clonidine suddenly, you may have withdrawal symptoms. These may include nervousness, agitation, headache, tremor, and rapid increase in blood pressure.

Misolast - Misoprostol Over The Counter Medication, Misolast

Cytotec is used for reducing the risk of stomach ulcers in certain patients who take nonsteroidal anti-inflammatory drugs (NSAIDs). Cytotec is a prostaglandin. It works by reducing the amount of acid released by the stomach and protecting the stomach lining, which helps to reduce the risk of stomach ulcers.

Use Cytotec as directed by your doctor!

Take Cytotec by mouth with food.

The last dose of the day should be taken at bedtime. Taking Cytotec after meals and at bedtime may decrease the risk of diarrhea.

Do not take an antacid that has magnesium in it within 1 hour before or 2 hours after you take Cytotec.

If you miss a dose of Cytotec, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Cytotec.

Store Cytotec at or below 77 degrees F (25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Cytotec out of the reach of children and away from pets.

Active Ingredient: Misoprostol.

Do NOT use Cytotec if:

you are allergic to any ingredient in Cytotec or to similar medicines (prostaglandins)

you are pregnant.

Contact your doctor right away if any of these apply to you.

Some medical conditions may interact with Cytotec. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are planning to become pregnant or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of heart disease, inflammatory bowel disease (eg, irritable bowel syndrome [IBS]), dehydration, or other problems that may be worsened if you become dehydrated.

Some medicines may interact with Cytotec. However, no specific interactions with Cytotec are known at this time.

Important safety information:

Cytotec may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Cytotec with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Cytotec may cause diarrhea, nausea, or stomach pain or cramps. If this occurs, it usually develops within the first few weeks after starting Cytotec. If these effects develop and last longer than 1 week, contact your health care provider.

Cytotec should be used with extreme caution in children; safety and effectiveness in children have not been confirmed.

If you may become pregnant, you must use an effective form of birth control while you take Cytotec. If you have questions about effective birth control, talk with your doctor.

Pregnancy and breast-feeding: Do not use Cytotec if you are pregnant. It has been shown to cause harm to the fetus. Avoid becoming pregnant while you are taking it. Avoid becoming pregnant for at least 1 month or through 1 menstrual cycle after you stop taking it. If you think you may be pregnant, contact your doctor right away. Cytotec is found in breast milk. Do not breastfeed while taking Cytotec.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Diarrhea; stomach pain.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; blood in the urine; changes in hearing or deafness; chest pain; fever; headache, dizziness, blurred vision; irregular heartbeat; mood or mental changes (eg, anxiety, confusion, depression); persistent or severe vomiting or diarrhea; severe fatigue, fainting; unusual bleeding or bruising; unusual tiredness or weakness; vomit that looks like coffee grounds; wheezing or shortness of breath.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Interactions, Usage, Facts, And Information On Napratec, Napratec

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Napratec

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Share your story! Tell us how MediGuard has helped you or someone you love. Download the MediGuard Mobile App to manage your prescription and over-the-counter medications, for free. Taking multiple medications puts you at risk for possible drug-drug interactions Monitor the medical treatment of you and your loved ones.

DISCLAIMER: MediGuard is not intended to be a substitute for professional medical advice. MediGuard cannot and does not take into consideration every possible interaction or account for individual responses to medicine. Different individuals may respond to medication in different ways. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective, or appropriate for any given patient. Always seek the advice of a qualified health provider with any questions you may have before making any changes to your treatment. The use of the MediGuard site and its content is at your own risk. The MediGuard site and the information contained in it is intended for users in the United States and information in other countries may be different.

© Quintiles 2016

Coverex As 10mg Tablets, Coverex-As

COVEREX AS 10MG TABLETS

Transcript

Coversyl Arginine 10mg Tablets (perindopril arginine) Patient Information Leaflet Read all of this leaflet carefully before you start taking this medicine because it contains important information for you. * Keep this leaflet. You may need to read it again. * If you have any further questions, ask your doctor, pharmacist or nurse. * This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours. * If you get any side effects, talk to your doctor, or pharmacist or nurse. This includes any possible side effects not listed in this leaflet. See section 4. Your medicine is called Coversyl Arginine 10mg tablets but will be reffered to as Coversyl Arginine through out this leaflet. What is in this leaflet: 1

What Coversyl Arginine is and what it is used for

What you need to know before you take Coversyl Arginine

How to take Coversyl Arginine

Possible side effects

How to store Coversyl Arginine

Content of the pack and other information

What Coversyl Arginine is and what it is used for

Coversyl Arginine is an angiotensin converting enzyme (ACE) inhibitor. These work by widening the blood vessels, which makes it easier for your heart to pump blood through them. Coversyl Arginine is used: * to treat high blood pressure (hypertension), * to treat heart failure (a condition where the heart is unable to pump enough blood to meet the body’s needs), * to reduce the risk of cardiac events, such as heart attack, in patients with stable coronary artery disease (a condition where the blood supply to the heart is reduced or blocked) and who have already had a heart attack and/or an operation to improve the blood supply to the heart by widening the vessels that supply it.

What you need to know before you take Coversyl Arginine

Do not take Coversyl Arginine * if you are allergic to perindopril, or any of the other ingredients of this medicine (listed in Section 6), or to any other ACE inhibitor * if you have experienced symptoms such as wheezing, swelling of the face, tongue or throat, intense itching or severe skin rashes with previous ACE inhibitor treatment or if you or a member of your family have had these symptoms in any other circumstances (a condition called angioedema). * if you are more than 3 months pregnant (it is also better to avoid Coversyl Arginine in early pregnancy - see pregnancy section), * if you have diabetes or impaired kidney function and you are treated with a blood pressure lowering medicine containing aliskiren. Warnings and precautions If any of the following apply to you please talk to your doctor or pharmacist or nurse before taking Coversyl Arginine if you: * have aortic stenosis (narrowing of the main blood vessel leading from the heart) or hypertrophic cardiomyopathy (heart muscle disease) or renal artery stenosis (narrowing of the artery supplying the kidney with blood), * have any other heart problems, * have liver problems, * have kidney problems or if you are receiving dialysis, * suffer from a collagen vascular disease (disease of the connective tissue) such as systemic lupus erythematosus or scleroderma, * have diabetes, * are on a salt restricted diet or use salt substitutes which contain potassium, * are to undergo anaesthesia and/or major surgery, * are to undergo LDL apheresis (which is removal of cholesterol from your blood by a machine), * are going to have desensitisation treatment to reduce the effects of an allergy to bee or wasp stings, * have recently suffered from diarrhoea or vomiting, or are dehydrated, * have been told by your doctor that you have an intolerance to some sugars. * are taking any of the following medicines used to treat high blood pressure: - an “angiotensin II receptor blocker” (ARBs) (also known as sartans - for example valsartan, telmisartan, irbesartan), in particular if you have diabetes-related kidney problems, - aliskiren Your doctor may check your kidney function, blood pressure, and the amount of electrolytes (e. g. potassium) in your blood at regular intervals. See also information under the heading “Do not take Coversyl Arginine”. * are of black origin since you may have a higher risk of angioedema and this medicine may be less effective in lowering your blood pressure than in non-black patients. Angioedema Angioedema (a severe allergic reaction with swelling of the face, lips, tongue or throat with difficulty in swallowing or breathing) has been reported in patients treated with ACE inhibitors, including Coversyl Arginine. This may occur at any time during treatment. If you develop such symptoms, you should stop taking Coversyl Arginine and see a doctor immediately. See also section 4.

You must tell your doctor if you think you are (or might become) pregnant. Coversyl Arginine is not recommended in early pregnancy, and must not be taken if you are more than 3 months pregnant, as it may cause serious harm to your baby if used at that stage (see pregnancy section). Children and adolescents The use of perindopril in children and adolescents up to the age of 18 years is not recommended. Other medicines and Coversyl Arginine Please tell your doctor or pharmacist if you are taking or have recently taken or might take any other medicines. Treatment with Coversyl Arginine can be affected by other medicines. Your doctor may need to change your dose and/or to take other precautions. These include: * other medicines for high blood pressure, including angiotensin II receptor blockers (ARB), aliskiren (see also information under the headings “Do not take Coversyl Arginine” and “Warnings and precautions”) or diuretics (medicines which increase the amount of urine produced by the kidneys), * potassium-sparing drugs (e. g. triamterene, amiloride), potassium supplements or potassium-containing salt substitutes, * potassium-sparing drugs used in the treatment of heart failure: eplerenone and spironolactone at doses between 12.5mg to 50mg per day. * lithium for mania or depression, * non-steroidal anti-inflammatory drugs (e. g. ibuprofen) for pain relief or high dose aspirin, * medicines to treat diabetes (such as insulin or metformin), * baclofen (used to treat muscle stiffness in diseases such as multiple sclerosis), * medicines to treat mental disorders such as depression, anxiety, schizophrenia etc (e. g. tricyclic antidepressants, antipsychotics), * immunosuppressants (medicines which reduce the defence mechanism of the body) used for the treatment of auto-immune disorders or following transplant surgery (e. g. ciclosporin, tacrolimus), * trimethoprim (for the treatment of infections), * estramustine (used in cancer therapy), * allopurinol (for the treatment of gout), * procainamide (for the treatment of an irregular heart beat), * vasodilators including nitrates (products that make the blood vessels become wider), * heparin (medicines used to thin blood), * medicines used for the treatment of low blood pressure, shock or asthma (e. g. ephedrine, noradrenaline or adrenaline). * gold salts, especially with intravenous administration (used to treat symptoms of rheumatoid arthritis). Coversyl Arginine with food and drink It is preferable to take Coversyl Arginine before a meal. Pregnancy and breast-feeding If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine. Pregnancy You must tell your doctor if you think you are (or might become) pregnant. Your doctor will normally advise you to stop taking Coversyl Arginine before you become pregnant or as soon as you know you are pregnant and will advise you to take another medicine instead of Coversyl Arginine. Coversyl Arginine is not recommended in early pregnancy, and must not be taken when more than 3 months pregnant, as it may cause serious harm to your baby if used after the third month of pregnancy. Breast-feeding Tell your doctor if you are breast-feeding or about to start breast-feeding. Coversyl Arginine is not recommended for mothers who are breast-feeding, and your doctor may choose another treatment for you if you wish to breast-feed, especially if your baby is newborn, or was born prematurely. Driving and using machines Coversyl Arginine usually does not affect alertness but dizziness or weakness due to low blood pressure may occur in certain patients. If you are affected in this way, your ability to drive or to operate machinery may be impaired. Coversyl Arginine contains lactose Coversyl Arginine contains lactose. If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product.

How to take Coversyl Arginine

Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure. Swallow your tablet with a glass of water, preferably at the same time each day, in the morning, before a meal. Your doctor will decide on the correct dose for you. The recommended dosages are as follows: High blood pressure: the usual starting and maintenance dose is 5 mg once daily. After one month, this can be increased to 10 mg once a day if required. 10 mg a day is the maximum recommended dose for high blood pressure. If you are 65 or older, the usual starting dose is 2.5 mg once a day. After a month this can be increased to 5 mg once a day and then if necessary to 10 mg once daily.

Coversyl Arginine 10mg Tablets (perindopril arginine) Patient Information Leaflet (continued) Heart failure: the usual starting dose is 2.5 mg once daily. After two weeks, this can be increased to 5 mg once a day, which is the maximum recommended dose for heart failure. Stable coronary artery disease: the usual starting dose is 5 mg once daily. After two weeks, this can be increased to 10 mg once daily, which is the maximum recommended dose in this indication. If you are 65 or older, the usual starting dose is 2.5 mg once a day. After a week this can be increased to 5 mg once a day and after a further week to 10 mg once daily. Use in children and adolescents Use in children and adolescents is not recommended. If you take more Coversyl Arginine than you should If you take too many tablets, contact your nearest accident and emergency department or tell your doctor immediately. The most likely effect in case of overdose is low blood pressure which can make you feel dizzy or faint. If this happens, lying down with the legs raised can help. If you forget to take Coversyl Arginine Its important to take your medicine every day as regular treatment works better. However, if you forget to take a dose of Coversyl Arginine, take the next dose at the usual time. Do not take a double dose to make up for a forgotten dose. If you stop taking Coversyl Arginine As the treatment with Coversyl Arginine is usually life-long, you should discuss with your doctor before stopping this medicinal product. If you have any further questions on the use of this medicine, ask your doctor, pharmacist or nurse.

chest pain, malaise, oedema peripheral, fever, fall, change in laboratory parameters: high blood level of potassium reversible on discontinuation, low level of sodium, hypoglycaemia (very low blood sugar level) in case of diabetic patients, increased blood urea, and increased blood creatinine.

Rare (may affect up to 1 in 1000 people): * changes in laboratory parameters: Increased level of liver enzymes, high level of serum bilirubin. Very rare (may affect up to 1 in 10,000 people): * confusion * eosinophilic pneumonia (a rare type of pneumonia), * rhinitis (blocked up or runny nose), * acute renal failure * changes in blood values such as a lower number of white and red blood cells, lower haemoglobin, lower number of blood platelets. Reporting of side effects If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at www. mhra. gov. uk/yellowcard By reporting side effects, you can help provide more information on the safety of this medicine.

How to store Coversyl Arginine

Keep out of the sight and reach of children. Keep container tightly closed, protect from mositure. 4

Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them. Stop taking the medicinal product and see a doctor immediately, if you experience any of the following side effects that can be serious: * swelling of the face, lips, mouth, tongue or throat, difficulty in breathing (angioedema) (See section 2 “Warnings and precautions”) (Uncommon - may affect up to 1 in 100 people), * severe dizziness or fainting due to low blood pressure (Common - may affect up to 1 in 10 people), * unusual fast or irregular heart beat, chest pain (angina) or heart attack (Very rare - may affect up to 1 in 10,000 people), * weakness of arms or legs, or problems speaking which could be a sign of a possible stroke (Very rare - may affect up to 1 in 10,000 people), * sudden wheeziness, chest pain, shortness of breath, or difficulty in breathing (bronchospasm) (Uncommon - may affect up to 1 in 100 people), * inflamed pancreas which may cause severe abdominal and back pain accompanied with feeling very unwell (Very rare - may affect up to 1 in 10,000 people), * yellowing of the skin or eyes (jaundice) which could be a sign of hepatitis (Very rare - may affect up to 1 in 10,000 people), * skin rash which often starts with red itchy patches on your face, arms or legs (erythema multiforme) (Very rare - may affect up to 1 in 10,000 people). Tell your doctor if you notice any of the following side effects: Common (may affect up to 1 in 10 people): * headache, * dizziness, * vertigo, * pins and needles, * vision disturbances, * tinnitus (sensation of noises in the ears), * cough, * shortness of breath (dyspnoea), * gastrointestinal disorders (nausea, vomiting, abdominal pain, taste disturbances, dyspepsia or difficulty of digestion, diarrhoea, constipation), * allergic reactions (such as skin rashes, itching), * muscle cramps, * feeling of weakness, Uncommon (may affect up to 1 in 100 people): * mood swings, * sleep disturbances, * dry mouth, * intense itching or severe skin rashes, * formation of blister clusters over the skin, * kidney problems, * impotence, * sweating, * excess of eosinophils (a type of white blood cells), * somnolence, * fainting, * palpitations, * tachycardia, * vasculitis (inflammation of blood vessels), * photosensitivity reaction (increased sensitivity of the skin to sun), * arthralgia (joint pain), * myalgia (muscle pain),

Do not use Coversyl Arginine after the expiry date which is stated on the carton and bottle. The expiry date refers to the last day of that month. If your medicine becomes discoloured or shows any other signs of deterioration consult your pharmacist who will tell you what to do. Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

Content of the pack and other information

What Coversyl Arginine contains * The active substance is perindopril arginine. One film-coated tablet contains 6.790 mg perindopril corresponding to 10 mg Perindopril Arginine. * The other ingredients in the tablet core are: lactose monohydrate, magnesium stearate E470B, maltodextrin, hydrophobic colloidal silica, sodium starch glycolate (type A), and in the tablet film-coating: glycerol E422, hypromellose E464, macrogol, magnesium stearate E470B , titanium dioxide E171 and copper chlorophyllin complex E141. What Coversyl Arginine looks like and contents of the pack Coversyl Arginine is green, round, biconvex, film-coated tablet engraved with a heart on one side and the Servier logo on the other side. Coversyl Arginine is available in bottles of 30. Manufacturer and Licence Holder This medicine is manufactured by Les Laboratoires Servier Industrie, 905, route de Saran, Gidy 45520, France. Procured from within the EU. Product Licence Holder: LTT Pharma Limited, Unit 18, Oxleasow Road, East Moons Moat, Redditch, Worcestershire, B98 0RE. Repackaged by Lexon (UK) Limited, B98 0RE. If you have any questions or are not sure about anything, ask your doctor or pharmacist. They will have additional information about this medicine and will be able to advise you.

Coversyl Arginine 10mg Tablets

Coversyl is a registered trademark of Biofarma. Revision date: 24/02/16

Blind or partially sighted? Is this leaflet hard to see or read? Phone LTT Pharma Limited, Tel: 01527 505414 for help.

Coverex AS 10mg Tablets (perindopril arginine) Patient Information Leaflet Read all of this leaflet carefully before you start taking this medicine because it contains important information for you. * Keep this leaflet. You may need to read it again. * If you have any further questions, ask your doctor, pharmacist or nurse. * This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours. * If you get any side effects, talk to your doctor, or pharmacist or nurse. This includes any possible side effects not listed in this leaflet. See section 4. Your medicine is called Coverex AS 5mg tablets but will be referred to as Coverex AS through out this leaflet. What is in this leaflet: 1 What Coverex AS is and what it is used for 2

What you need to know before you take Coverex AS

How to take Coverex AS

Possible side effects

How to store Coverex AS

Content of the pack and other information

What Coverex AS is and what it is used for

Coverex AS is an angiotensin converting enzyme (ACE) inhibitor. These work by widening the blood vessels, which makes it easier for your heart to pump blood through them. Coverex AS is used: * to treat high blood pressure (hypertension), * to treat heart failure (a condition where the heart is unable to pump enough blood to meet the body’s needs), * to reduce the risk of cardiac events, such as heart attack, in patients with stable coronary artery disease (a condition where the blood supply to the heart is reduced or blocked) and who have already had a heart attack and/or an operation to improve the blood supply to the heart by widening the vessels that supply it. 2

What you need to know before you take Coverex AS

Do not take Coverex AS

* if you are allergic to perindopril, or any of the other ingredients of this medicine (listed in Section 6), or to any other ACE inhibitor * if you have experienced symptoms such as wheezing, swelling of the face,

tongue or throat, intense itching or severe skin rashes with previous ACE inhibitor treatment or if you or a member of your family have had these symptoms in any other circumstances (a condition called angioedema). if you are more than 3 months pregnant (it is also better to avoid Coverex AS in early pregnancy - see pregnancy section), If you have diabetes or impaired kidney function and you are treated with a blood pressure lowering medicine containing aliskiren.

Warnings and precautions If any of the following apply to you please talk to your doctor or pharmacist or nurse before taking Coverex AS if you: * have aortic stenosis (narrowing of the main blood vessel leading from the heart) or hypertrophic cardiomyopathy (heart muscle disease) or renal artery stenosis (narrowing of the artery supplying the kidney with blood), * have any other heart problems, * have liver problems, * have kidney problems or if you are receiving dialysis, * suffer from a collagen vascular disease (disease of the connective tissue) such as systemic lupus erythematosus or scleroderma, * have diabetes, * are on a salt restricted diet or use salt substitutes which contain potassium, * are to undergo anaesthesia and/or major surgery, * are to undergo LDL apheresis (which is removal of cholesterol from your blood by a machine), * are going to have desensitisation treatment to reduce the effects of an allergy to bee or wasp stings, * have recently suffered from diarrhoea or vomiting, or are dehydrated, * have been told by your doctor that you have an intolerance to some sugars. * are taking any of the following medicines used to treat high blood pressure: - an “angiotensin II receptor blocker” (ARBs) (also known as sartans - for example valsartan, telmisartan, irbesartan), in particular if you have diabetes-related kidney problems, - aliskiren Your doctor may check your kidney function, blood pressure, and the amount of electrolytes (e. g. potassium) in your blood at regular intervals. See also information under the heading “Do not take Coverex AS”. * are of black origin since you may have a higher risk of angioedema and this medicine may be less effective in lowering your blood pressure than in non-black patients. Angioedema Angioedema (a severe allergic reaction with swelling of the face, lips, tongue or throat with difficulty in swallowing or breathing) has been reported in patients treated with ACE inhibitors, including Coverex AS. This may occur at any time during treatment. If you develop such symptoms, you should stop taking Coverex AS and see a doctor immediately. See also section 4.

You must tell your doctor if you think you are (or might become) pregnant. Coverex AS is not recommended in early pregnancy, and must not be taken if you are more than 3 months pregnant, as it may cause serious harm to your baby if used at that stage (see pregnancy section). Children and adolescents The use of perindopril in children and adolescents up to the age of 18 years is not recommended. Other medicines and Coverex AS Please tell your doctor or pharmacist if you are taking or have recently taken or might take any other medicines. Treatment with Coverex AS can be affected by other medicines. Your doctor may need to change your dose and/or to take other precautions. These include: * other medicines for high blood pressure, including angiotensin II receptor blockers (ARB), aliskiren (see also information under the headings “Do not take Coverex AS” and “Warnings and precautions”) or diuretics (medicines which increase the amount of urine produced by the kidneys), * potassium-sparing drugs (e. g. triamterene, amiloride), potassium supplements or potassium-containing salt substitutes, * potassium-sparing drugs used in the treatment of heart failure: eplerenone and spironolactone at doses between 12.5mg to 50mg per day. lithium for mania or depression, * * non-steroidal anti-inflammatory drugs (e. g. ibuprofen) for pain relief or high dose aspirin, * medicines to treat diabetes (such as insulin or metformin), * baclofen (used to treat muscle stiffness in diseases such as multiple sclerosis), * medicines to treat mental disorders such as depression, anxiety, schizophrenia etc (e. g. tricyclic antidepressants, antipsychotics), * immunosuppressants (medicines which reduce the defence mechanism of the body) used for the treatment of auto-immune disorders or following transplant surgery (e. g. ciclosporin, tacrolimus), * trimethoprim (for the treatment of infections), * estramustine (used in cancer therapy), * allopurinol (for the treatment of gout), * procainamide (for the treatment of an irregular heart beat), * vasodilators including nitrates (products that make the blood vessels become wider), * heparin (medicines used to thin blood), * medicines used for the treatment of low blood pressure, shock or asthma (e. g. ephedrine, noradrenaline or adrenaline). * gold salts, especially with intravenous administration (used to treat symptoms of rheumatoid arthritis). Coverex AS with food and drink It is preferable to take Coverex AS before a meal. Pregnancy and breast-feeding If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine. Pregnancy You must tell your doctor if you think you are (or might become) pregnant. Your doctor will normally advise you to stop taking Coverer AS before you become pregnant or as soon as you know you are pregnant and will advise you to take another medicine instead of Coverex AS. Coverex AS is not recommended in early pregnancy, and must not be taken when more than 3 months pregnant, as it may cause serious harm to your baby if used after the third month of pregnancy. Breast-feeding Tell your doctor if you are breast-feeding or about to start breast-feeding. Coverex AS is not recommended for mothers who are breast-feeding, and your doctor may choose another treatment for you if you wish to breast-feed, especially if your baby is newborn, or was born prematurely. Driving and using machines Coverex AS usually does not affect alertness but dizziness or weakness due to low blood pressure may occur in certain patients. If you are affected in this way, your ability to drive or to operate machinery may be impaired. Coverex AS contains lactose Coverex AS contains lactose. If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product.

How to take Coverex AS

Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure. Swallow your tablet with a glass of water, preferably at the same time each day, in the morning, before a meal. Your doctor will decide on the correct dose for you. The recommended dosages are as follows: High blood pressure: the usual starting and maintenance dose is 5 mg once daily. After one month, this can be increased to 10 mg once a day if required. 10 mg a day is the maximum recommended dose for high blood pressure. If you are 65 or older, the usual starting dose is 2.5 mg once a day. After a month this can be increased to 5 mg once a day and then if necessary to 10 mg once daily.

Coverex AS 10mg Tablets (perindopril arginine) Patient Information Leaflet (continued) Heart failure: the usual starting dose is 2.5 mg once daily. After two weeks, this can be increased to 5 mg once a day, which is the maximum recommended dose for heart failure. Stable coronary artery disease: the usual starting dose is 5 mg once daily. After two weeks, this can be increased to 10 mg once daily, which is the maximum recommended dose in this indication. If you are 65 or older, the usual starting dose is 2.5 mg once a day. After a week this can be increased to 5 mg once a day and after a further week to 10 mg once daily. Use in children and adolescents Use in children and adolescents is not recommended. If you take more Coverex AS than you should If you take too many tablets, contact your nearest accident and emergency department or tell your doctor immediately. The most likely effect in case of overdose is low blood pressure which can make you feel dizzy or faint. If this happens, lying down with the legs raised can help. If you forget to take Coverex AS Its important to take your medicine every day as regular treatment works better. However, if you forget to take a dose of Coverex AS, take the next dose at the usual time. Do not take a double dose to make up for a forgotten dose. If you stop taking Coverex AS As the treatment with Coverex AS is usually life-long, you should discuss with your doctor before stopping this medicinal product. If you have any further questions on the use of this medicine, ask your doctor, pharmacist or nurse.

Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them. Stop taking the medicinal product and see a doctor immediately, if you experience any of the following side effects that can be serious: * swelling of the face, lips, mouth, tongue or throat, difficulty in breathing (angioedema) (See section 2 “Warnings and precautions”) (Uncommon - may affect up to 1 in 100 people), * severe dizziness or fainting due to low blood pressure (Common - may affect up to 1 in 10 people), * unusual fast or irregular heart beat, chest pain (angina) or heart attack (Very rare - may affect up to 1 in 10,000 people), * weakness of arms or legs, or problems speaking which could be a sign of a possible stroke (Very rare - may affect up to 1 in 10,000 people), * sudden wheeziness, chest pain, shortness of breath, or difficulty in breathing (bronchospasm) (Uncommon - may affect up to 1 in 100 people), * inflamed pancreas which may cause severe abdominal and back pain accompanied with feeling very unwell (Very rare - may affect up to 1 in 10,000 people), * yellowing of the skin or eyes (jaundice) which could be a sign of hepatitis (Very rare - may affect up to 1 in 10,000 people), skin rash which often starts with red itchy patches on your face, arms or * legs (erythema multiforme) (Very rare - may affect up to 1 in 10,000 people). Tell your doctor if you notice any of the following side effects: Common (may affect up to 1 in 10 people): * headache, * dizziness, * vertigo, * pins and needles, * vision disturbances, * tinnitus (sensation of noises in the ears), * cough, * shortness of breath (dyspnoea), * gastrointestinal disorders (nausea, vomiting, abdominal pain, taste disturbances, dyspepsia or difficulty of digestion, diarrhoea, constipation), * allergic reactions (such as skin rashes, itching), * muscle cramps, * feeling of weakness, Uncommon (may affect up to 1 in 100 people): * mood swings, * sleep disturbances, * dry mouth, * intense itching or severe skin rashes, * formation of blister clusters over the skin, * kidney problems, * impotence, * sweating, * excess of eosinophils (a type of white blood cells), * somnolence, * fainting, * palpitations, * tachycardia, * vasculitis (inflammation of blood vessels), * photosensitivity reaction (increased sensitivity of the skin to sun), * arthralgia (joint pain), * myalgia (muscle pain), * chest pain, * malaise, * oedema peripheral,

fever, fall, change in laboratory parameters: high blood level of potassium reversible on discontinuation, low level of sodium, hypoglycaemia (very low blood sugar level) in case of diabetic patients, increased blood urea, and increased blood creatinine.

Rare (may affect up to 1 in 1000 people): * changes in laboratory parameters: Increased level of liver enzymes, high level of serum bilirubin. Very rare (may affect up to 1 in 10,000 people): * confusion * eosinophilic pneumonia (a rare type of pneumonia), * rhinitis (blocked up or runny nose), * acute renal failure * changes in blood values such as a lower number of white and red blood cells, lower haemoglobin, lower number of blood platelets. Reporting of side effects If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at www. mhra. gov. uk/yellowcard. By reporting side effects, you can help provide more information on the safety of this medicine.

How to store Coverex AS

Keep out of the sight and reach of children. Keep container tightly closed, protect from mositure. Do not use Coverex AS after the expiry date which is stated on the carton and bottle. The expiry date refers to the last day of that month. If your medicine becomes discoloured or shows any other signs of deterioration consult your pharmacist who will tell you what to do. Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

Content of the pack and other information

What Coverex AS contains * The active substance is perindopril arginine. One film-coated tablet contains 6.790 mg perindopril corresponding to 10 mg Perindopril Arginine. * The other ingredients in the tablet core are: lactose monohydrate, magnesium stearate E470B, maltodextrin, hydrophobic colloidal silica, sodium starch glycolate (type A), and in the tablet film-coating: glycerol E422, hypromellose E464, macrogol, magnesium stearate E470B , titanium dioxide E171 and copper chlorophyllin complex E141. What Coverex AS looks like and contents of the pack Coverex AS is green, round, biconvex, film-coated tablet engraved with a heart on one side and the Servier logo on the other side. Coverex AS is available in bottles of 30. Manufacturer and Licence Holder This medicine is manufactured by Les Laboratoires Servier Industrie, 905, route de Saran, Gidy 45520, France. Procured from within the EU. Product Licence Holder: LTT Pharma Limited, Unit 18, Oxleasow Road, East Moons Moat, Redditch, Worcestershire, B98 0RE. Repackaged by Lexon (UK) Limited, B98 0RE. If you have any questions or are not sure about anything, ask your doctor or pharmacist. They will have additional information about this medicine and will be able to advise you.

Coverex AS 10mg Tablets

Coverex is a registered trademark of Biofarma. Revision date: 24/02/16

Blind or partially sighted? Is this leaflet hard to see or read? Phone LTT Pharma Limited, Tel: 01527 505414 for help.

Perindopril Arginine 10mg Tablets (perindopril arginine) Patient Information Leaflet Read all of this leaflet carefully before you start taking this medicine because it contains important information for you. * Keep this leaflet. You may need to read it again. * If you have any further questions, ask your doctor, pharmacist or nurse. * This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours. * If you get any side effects, talk to your doctor, or pharmacist or nurse. This includes any possible side effects not listed in this leaflet. See section 4. Your medicine is called Perindopril Arginine 5mg tablets but will be referred to as Perindopril Arginine through out this leaflet. What is in this leaflet: 1 What Perindopril Arginine is and what it is used for 2 What you need to know before you take Perindopril Arginine 3 How to take Perindopril Arginine 4 Possible side effects 5 How to store Perindopril Arginine 6 Content of the pack and other information

What Perindopril Arginine is and what it is used for

Perindopril Arginine is an angiotensin converting enzyme (ACE) inhibitor. These work by widening the blood vessels, which makes it easier for your heart to pump blood through them. Perindopril Arginine is used: * to treat high blood pressure (hypertension), * to treat heart failure (a condition where the heart is unable to pump enough blood to meet the body’s needs), * to reduce the risk of cardiac events, such as heart attack, in patients with stable coronary artery disease (a condition where the blood supply to the heart is reduced or blocked) and who have already had a heart attack and/or an operation to improve the blood supply to the heart by widening the vessels that supply it.

What you need to know before you take Perindopril Arginine

Do not take Perindopril Arginine * if you are allergic to perindopril, or any of the other ingredients of this medicine (listed in Section 6), or to any other ACE inhibitor * if you have experienced symptoms such as wheezing, swelling of the face, tongue or throat, intense itching or severe skin rashes with previous ACE inhibitor treatment or if you or a member of your family have had these symptoms in any other circumstances (a condition called angioedema). * if you are more than 3 months pregnant (it is also better to avoid Perindopril Arginine in early pregnancy - see pregnancy section), * If you have diabetes or impaired kidney function and you are treated with a blood pressure lowering medicine containing aliskiren. Warnings and precautions If any of the following apply to you please talk to your doctor or pharmacist or nurse before taking Perindopril Arginine if you: * have aortic stenosis (narrowing of the main blood vessel leading from the heart) or hypertrophic cardiomyopathy (heart muscle disease) or renal artery stenosis (narrowing of the artery supplying the kidney with blood), * have any other heart problems, * have liver problems, * have kidney problems or if you are receiving dialysis, * suffer from a collagen vascular disease (disease of the connective tissue) such as systemic lupus erythematosus or scleroderma, * have diabetes, * are on a salt restricted diet or use salt substitutes which contain potassium, * are to undergo anaesthesia and/or major surgery, * are to undergo LDL apheresis (which is removal of cholesterol from your blood by a machine), * are going to have desensitisation treatment to reduce the effects of an allergy to bee or wasp stings, * have recently suffered from diarrhoea or vomiting, or are dehydrated, * have been told by your doctor that you have an intolerance to some sugars. * are taking any of the following medicines used to treat high blood pressure: - an “angiotensin II receptor blocker” (ARBs) (also known as sartans - for example valsartan, telmisartan, irbesartan), in particular if you have diabetes-related kidney problems, - aliskiren Your doctor may check your kidney function, blood pressure, and the amount of electrolytes (e. g. potassium) in your blood at regular intervals. See also information under the heading “Do not take Perindopril Arginine”. * are of black origin since you may have a higher risk of angioedema and this medicine may be less effective in lowering your blood pressure than in non-black patients. Angioedema Angioedema (a severe allergic reaction with swelling of the face, lips, tongue or throat with difficulty in swallowing or breathing) has been reported in patients treated with ACE inhibitors, including Perindopril Arginine. This may occur at any time during treatment. If you develop such symptoms, you should stop taking Perindopril Arginine and see a doctor immediately. See also section 4.

You must tell your doctor if you think you are (or might become) pregnant. Perindopril Arginine is not recommended in early pregnancy, and must not be taken if you are more than 3 months pregnant, as it may cause serious harm to your baby if used at that stage (see pregnancy section). Children and adolescents The use of perindopril in children and adolescents up to the age of 18 years is not recommended. Other medicines and Perindopril Arginine Please tell your doctor or pharmacist if you are taking or have recently taken or might take any other medicines. Treatment with Perindopril Arginine can be affected by other medicines. Your doctor may need to change your dose and/or to take other precautions. These include: * other medicines for high blood pressure, including angiotensin II receptor blockers (ARB), aliskiren (see also information under the headings “Do not take Perindopril Arginine and “Warnings and precautions”) or diuretics (medicines which increase the amount of urine produced by the kidneys), * potassium-sparing drugs (e. g. triamterene, amiloride), potassium supplements or potassium-containing salt substitutes, * potassium-sparing drugs used in the treatment of heart failure: eplerenone and spironolactone at doses between 12.5mg to 50mg per day. * lithium for mania or depression, * non-steroidal anti-inflammatory drugs (e. g. ibuprofen) for pain relief or high dose aspirin, * medicines to treat diabetes (such as insulin or metformin), * baclofen (used to treat muscle stiffness in diseases such as multiple sclerosis), * medicines to treat mental disorders such as depression, anxiety, schizophrenia etc (e. g. tricyclic antidepressants, antipsychotics), * immunosuppressants (medicines which reduce the defence mechanism of the body) used for the treatment of auto-immune disorders or following transplant surgery (e. g. ciclosporin, tacrolimus), * trimethoprim (for the treatment of infections), * estramustine (used in cancer therapy), * allopurinol (for the treatment of gout), * procainamide (for the treatment of an irregular heart beat), * vasodilators including nitrates (products that make the blood vessels become wider), * heparin (medicines used to thin blood), * medicines used for the treatment of low blood pressure, shock or asthma (e. g. ephedrine, noradrenaline or adrenaline). * gold salts, especially with intravenous administration (used to treat symptoms of rheumatoid arthritis). Perindopril Arginine with food and drink It is preferable to take Perindopril Arginine before a meal. Pregnancy and breast-feeding If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine. Pregnancy You must tell your doctor if you think you are (or might become) pregnant. Your doctor will normally advise you to stop taking Perindopril Arginine before you become pregnant or as soon as you know you are pregnant and will advise you to take another medicine instead of Perindopril Arginine. Perindopril Arginine is not recommended in early pregnancy, and must not be taken when more than 3 months pregnant, as it may cause serious harm to your baby if used after the third month of pregnancy. Breast-feeding Tell your doctor if you are breast-feeding or about to start breast-feeding. Perindopril Arginine is not recommended for mothers who are breastfeeding, and your doctor may choose another treatment for you if you wish to breast-feed, especially if your baby is newborn, or was born prematurely. Driving and using machines Perindopril Arginine usually does not affect alertness but dizziness or weakness due to low blood pressure may occur in certain patients. If you are affected in this way, your ability to drive or to operate machinery may be impaired. Perindopril Arginine contains lactose Perindopril Arginine contains lactose. If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product.

How to take Perindopril Arginine

Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure. Swallow your tablet with a glass of water, preferably at the same time each day, in the morning, before a meal. Your doctor will decide on the correct dose for you. The recommended dosages are as follows: High blood pressure: the usual starting and maintenance dose is 5 mg once daily. After one month, this can be increased to 10 mg once a day if required. 10 mg a day is the maximum recommended dose for high blood pressure.

Perindopril Arginine 10mg Tablets (perindopril arginine) Patient Information Leaflet (continued) If you are 65 or older, the usual starting dose is 2.5 mg once a day. After a month this can be increased to 5 mg once a day and then if necessary to 10 mg once daily. Heart failure: the usual starting dose is 2.5 mg once daily. After two weeks, this can be increased to 5 mg once a day, which is the maximum recommended dose for heart failure. Stable coronary artery disease: the usual starting dose is 5 mg once daily. After two weeks, this can be increased to 10 mg once daily, which is the maximum recommended dose in this indication. If you are 65 or older, the usual starting dose is 2.5 mg once a day. After a week this can be increased to 5 mg once a day and after a further week to 10 mg once daily. Use in children and adolescents Use in children and adolescents is not recommended. If you take more Perindopril Arginine than you should If you take too many tablets, contact your nearest accident and emergency department or tell your doctor immediately. The most likely effect in case of overdose is low blood pressure which can make you feel dizzy or faint. If this happens, lying down with the legs raised can help. If you forget to take Perindopril Arginine Its important to take your medicine every day as regular treatment works better. However, if you forget to take a dose of Perindopril Arginine, take the next dose at the usual time. Do not take a double dose to make up for a forgotten dose.

chest pain, malaise, oedema peripheral, fever, fall, change in laboratory parameters: high blood level of potassium reversible on discontinuation, low level of sodium, hypoglycaemia (very low blood sugar level) in case of diabetic patients, increased blood urea, and increased blood creatinine.

Rare (may affect up to 1 in 1000 people): * changes in laboratory parameters: Increased level of liver enzymes, high level of serum bilirubin. Very rare (may affect up to 1 in 10,000 people): * confusion * eosinophilic pneumonia (a rare type of pneumonia), * rhinitis (blocked up or runny nose), * acute renal failure * changes in blood values such as a lower number of white and red blood cells, lower haemoglobin, lower number of blood platelets. Reporting of side effects If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at www. mhra. gov. uk/yellowcard By reporting side effects, you can help provide more information on the safety of this medicine. 5

If you stop taking Perindopril Arginine As the treatment with Perindopril Arginine is usually life-long, you should discuss with your doctor before stopping this medicinal product. If you have any further questions on the use of this medicine, ask your doctor, pharmacist or nurse.

How to store Perindopril Arginine

Keep out of the sight and reach of children. Keep container tightly closed, protect from mositure. Do not use Perindopril Arginine after the expiry date which is stated on the carton and bottle. The expiry date refers to the last day of that month.

Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them. Stop taking the medicinal product and see a doctor immediately, if you experience any of the following side effects that can be serious: * swelling of the face, lips, mouth, tongue or throat, difficulty in breathing (angioedema) (See section 2 “Warnings and precautions”) (Uncommon - may affect up to 1 in 100 people), * severe dizziness or fainting due to low blood pressure (Common - may affect up to 1 in 10 people), * unusual fast or irregular heart beat, chest pain (angina) or heart attack (Very rare - may affect up to 1 in 10,000 people), * weakness of arms or legs, or problems speaking which could be a sign of a possible stroke (Very rare - may affect up to 1 in 10,000 people), * sudden wheeziness, chest pain, shortness of breath, or difficulty in breathing (bronchospasm) (Uncommon - may affect up to 1 in 100 people), * inflamed pancreas which may cause severe abdominal and back pain accompanied with feeling very unwell (Very rare - may affect up to 1 in 10,000 people), * yellowing of the skin or eyes (jaundice) which could be a sign of hepatitis (Very rare - may affect up to 1 in 10,000 people), * skin rash which often starts with red itchy patches on your face, arms or legs (erythema multiforme) (Very rare - may affect up to 1 in 10,000 people). Tell your doctor if you notice any of the following side effects: Common (may affect up to 1 in 10 people): * headache, * dizziness, * vertigo, * pins and needles, * vision disturbances, * tinnitus (sensation of noises in the ears), * cough, * shortness of breath (dyspnoea), * gastrointestinal disorders (nausea, vomiting, abdominal pain, taste disturbances, dyspepsia or difficulty of digestion, diarrhoea, constipation), * allergic reactions (such as skin rashes, itching), * muscle cramps, * feeling of weakness, Uncommon (may affect up to 1 in 100 people): * mood swings, * sleep disturbances, * dry mouth, * intense itching or severe skin rashes, * formation of blister clusters over the skin, * kidney problems, * impotence, * sweating, * excess of eosinophils (a type of white blood cells), * somnolence, * fainting, * palpitations, * tachycardia, * vasculitis (inflammation of blood vessels), * photosensitivity reaction (increased sensitivity of the skin to sun), * arthralgia (joint pain), * myalgia (muscle pain),

If your medicine becomes discoloured or shows any other signs of deterioration consult your pharmacist who will tell you what to do. Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

Content of the pack and other information

What Perindopril Arginine contains * The active substance is perindopril arginine. One film-coated tablet contains 6.790 mg perindopril corresponding to 10 mg Perindopril Arginine. * The other ingredients in the tablet core are: lactose monohydrate, magnesium stearate E470B, maltodextrin, hydrophobic colloidal silica, sodium starch glycolate (type A), and in the tablet film-coating: glycerol E422, hypromellose E464, macrogol, magnesium stearate E470B, titanium dioxide E171 and copper chlorophyllin complex E141. What Perindopril Arginine looks like and contents of the pack Perindopril Arginine is green, round, biconvex, film-coated tablet engraved with a heart on one side and the Servier logo on the other side. Perindopril Arginine is available in bottles of 30. Manufacturer and Licence Holder This medicine is manufactured by Les Laboratoires Servier Industrie, 905, route de Saran, Gidy 45520, France. Procured from within the EU. Product Licence Holder: LTT Pharma Limited, Unit 18, Oxleasow Road, East Moons Moat, Redditch, Worcestershire, B98 0RE. Repackaged by Lexon (UK) Limited, B98 0RE. If you have any questions or are not sure about anything, ask your doctor or pharmacist. They will have additional information about this medicine and will be able to advise you.

Perindopril Arginine 10mg Tablets

Revision date: 24/02/16

Blind or partially sighted? Is this leaflet hard to see or read? Phone LTT Pharma Limited, Tel: 01527 505414 for help.

Coversyl Arginine 10mg Tablets (perindopril arginine) Patient Information Leaflet Read all of this leaflet carefully before you start taking this medicine because it contains important information for you. * Keep this leaflet. You may need to read it again. * If you have any further questions, ask your doctor, pharmacist or nurse. * This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours. * If you get any side effects, talk to your doctor, or pharmacist or nurse. This includes any possible side effects not listed in this leaflet. See section 4. Your medicine is called Coversyl Arginine 10mg tablets but will be reffered to as Coversyl Arginine through out this leaflet. What is in this leaflet: 1

What Coversyl Arginine is and what it is used for

What you need to know before you take Coversyl Arginine

How to take Coversyl Arginine

Possible side effects

How to store Coversyl Arginine

Content of the pack and other information

What Coversyl Arginine is and what it is used for

Coversyl Arginine is an angiotensin converting enzyme (ACE) inhibitor. These work by widening the blood vessels, which makes it easier for your heart to pump blood through them. Coversyl Arginine is used: * to treat high blood pressure (hypertension), * to treat heart failure (a condition where the heart is unable to pump enough blood to meet the body’s needs), * to reduce the risk of cardiac events, such as heart attack, in patients with stable coronary artery disease (a condition where the blood supply to the heart is reduced or blocked) and who have already had a heart attack and/or an operation to improve the blood supply to the heart by widening the vessels that supply it.

What you need to know before you take Coversyl Arginine

Do not take Coversyl Arginine * if you are allergic to perindopril, or any of the other ingredients of this medicine (listed in Section 6), or to any other ACE inhibitor * if you have experienced symptoms such as wheezing, swelling of the face, tongue or throat, intense itching or severe skin rashes with previous ACE inhibitor treatment or if you or a member of your family have had these symptoms in any other circumstances (a condition called angioedema). * if you are more than 3 months pregnant (it is also better to avoid Coversyl Arginine in early pregnancy - see pregnancy section), * If you have diabetes or impaired kidney function and you are treated with blood pressure lowering medicine containing aliskiren. Warnings and precautions If any of the following apply to you please talk to your doctor or pharmacist or nurse before taking Coversyl Arginine if you: * have aortic stenosis (narrowing of the main blood vessel leading from the heart) or hypertrophic cardiomyopathy (heart muscle disease) or renal artery stenosis (narrowing of the artery supplying the kidney with blood), * have any other heart problems, * have liver problems, * have kidney problems or if you are receiving dialysis, * suffer from a collagen vascular disease (disease of the connective tissue) such as systemic lupus erythematosus or scleroderma, * have diabetes, * are on a salt restricted diet or use salt substitutes which contain potassium, * are to undergo anaesthesia and/or major surgery, * are to undergo LDL apheresis (which is removal of cholesterol from your blood by a machine), * are going to have desensitisation treatment to reduce the effects of an allergy to bee or wasp stings, * have recently suffered from diarrhoea or vomiting, or are dehydrated, * have been told by your doctor that you have an intolerance to some sugars. * are taking any of the following medicines used to treat high blood pressure: - an “angiotensin II receptor blocker” (ARBs) (also known as sartans - for example valsartan, telmisartan, irbesartan), in particular if you have diabetes-related kidney problems, - aliskiren Your doctor may check your kidney function, blood pressure, and the amount of electrolytes (e. g. potassium) in your blood at regular intervals. See also information under the heading “Do not take Coversyl Arginine”. * are of black origin since you may have a higher risk of angioedema and this medicine may be less effective in lowering your blood pressure than in non-black patients. Angioedema Angioedema (a severe allergic reaction with swelling of the face, lips, tongue or throat with difficulty in swallowing or breathing) has been reported in patients treated with ACE inhibitors, including Coversyl Arginine. This may occur at any time during treatment. If you develop such symptoms, you should stop taking Coversyl Arginine and see a doctor immediately. See also section 4.

You must tell your doctor if you think you are (or might become) pregnant. Coversyl Arginine is not recommended in early pregnancy, and must not be taken if you are more than 3 months pregnant, as it may cause serious harm to your baby if used at that stage (see pregnancy section). Children and adolescents The use of perindopril in children and adolescents up to the age of 18 years is not recommended. Other medicines and Coversyl Arginine Please tell your doctor or pharmacist if you are taking or have recently taken or might take any other medicines. Treatment with Coversyl Arginine can be affected by other medicines. Your doctor may need to change your dose and/or to take other precautions. These include: * other medicines for high blood pressure, including angiotensin II receptor blockers (ARB), aliskiren (see also information under the headings “Do not take Coversyl Arginine” and “Warnings and precautions”) or diuretics (medicines which increase the amount of urine produced by the kidneys), * potassium-sparing drugs (e. g. triamterene, amiloride), potassium supplements or potassium-containing salt substitutes, * potassium-sparing drugs used in the treatment of heart failure: eplerenone and spironolactone at doses between 12.5mg to 50mg per day. * lithium for mania or depression, * non-steroidal anti-inflammatory drugs (e. g. ibuprofen) for pain relief or high dose aspirin, * medicines to treat diabetes (such as insulin or metformin), * baclofen (used to treat muscle stiffness in diseases such as multiple sclerosis), * medicines to treat mental disorders such as depression, anxiety, schizophrenia etc (e. g. tricyclic antidepressants, antipsychotics), * immunosuppressants (medicines which reduce the defence mechanism of the body) used for the treatment of auto-immune disorders or following transplant surgery (e. g. ciclosporin, tacrolimus), * trimethoprim (for the treatment of infections), * estramustine (used in cancer therapy), * allopurinol (for the treatment of gout), * procainamide (for the treatment of an irregular heart beat), * vasodilators including nitrates (products that make the blood vessels become wider), * heparin (medicines used to thin blood), * medicines used for the treatment of low blood pressure, shock or asthma (e. g. ephedrine, noradrenaline or adrenaline). * gold salts, especially with intravenous administration (used to treat symptoms of rheumatoid arthritis). Coversyl Arginine with food and drink It is preferable to take Coversyl Arginine before a meal. Pregnancy and breast-feeding If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine. Pregnancy You must tell your doctor if you think you are (or might become) pregnant. Your doctor will normally advise you to stop taking Coversyl Arginine before you become pregnant or as soon as you know you are pregnant and will advise you to take another medicine instead of Coversyl Arginine. Coversyl Arginine is not recommended in early pregnancy, and must not be taken when more than 3 months pregnant, as it may cause serious harm to your baby if used after the third month of pregnancy. Breast-feeding Tell your doctor if you are breast-feeding or about to start breast-feeding. Coversyl Arginine is not recommended for mothers who are breast-feeding, and your doctor may choose another treatment for you if you wish to breast-feed, especially if your baby is newborn, or was born prematurely. Driving and using machines Coversyl Arginine usually does not affect alertness but dizziness or weakness due to low blood pressure may occur in certain patients. If you are affected in this way, your ability to drive or to operate machinery may be impaired. Coversyl Arginine contains lactose Coversyl Arginine contains lactose. If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product.

How to take Coversyl Arginine

Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure. Swallow your tablet with a glass of water, preferably at the same time each day, in the morning, before a meal. Your doctor will decide on the correct dose for you. The recommended dosages are as follows: High blood pressure: the usual starting and maintenance dose is 5 mg once daily. After one month, this can be increased to 10 mg once a day if required. 10 mg a day is the maximum recommended dose for high blood pressure. If you are 65 or older, the usual starting dose is 2.5 mg once a day. After a month this can be increased to 5 mg once a day and then if necessary to 10 mg once daily.

Coversyl Arginine 10mg Tablets (perindopril arginine) Patient Information Leaflet (continued) Heart failure: the usual starting dose is 2.5 mg once daily. After two weeks, this can be increased to 5 mg once a day, which is the maximum recommended dose for heart failure. Stable coronary artery disease: the usual starting dose is 5 mg once daily. After two weeks, this can be increased to 10 mg once daily, which is the maximum recommended dose in this indication. If you are 65 or older, the usual starting dose is 2.5 mg once a day. After a week this can be increased to 5 mg once a day and after a further week to 10 mg once daily. Use in children and adolescents Use in children and adolescents is not recommended. If you take more Coversyl Arginine than you should If you take too many tablets, contact your nearest accident and emergency department or tell your doctor immediately. The most likely effect in case of overdose is low blood pressure which can make you feel dizzy or faint. If this happens, lying down with the legs raised can help. If you forget to take Coversyl Arginine Its important to take your medicine every day as regular treatment works better. However, if you forget to take a dose of Coversyl Arginine, take the next dose at the usual time. Do not take a double dose to make up for a forgotten dose. If you stop taking Coversyl Arginine As the treatment with Coversyl Arginine is usually life-long, you should discuss with your doctor before stopping this medicinal product. If you have any further questions on the use of this medicine, ask your doctor, pharmacist or nurse.

chest pain, malaise, oedema peripheral, fever, fall, change in laboratory parameters: high blood level of potassium reversible on discontinuation, low level of sodium, hypoglycaemia (very low blood sugar level) in case of diabetic patients, increased blood urea, and increased blood creatinine.

Rare (may affect up to 1 in 1000 people): * changes in laboratory parameters: Increased level of liver enzymes, high level of serum bilirubin. Very rare (may affect up to 1 in 10,000 people): * confusion * eosinophilic pneumonia (a rare type of pneumonia), * rhinitis (blocked up or runny nose), * acute renal failure * changes in blood values such as a lower number of white and red blood cells, lower haemoglobin, lower number of blood platelets. Reporting of side effects If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at www. mhra. gov. uk/yellowcard By reporting side effects, you can help provide more information on the safety of this medicine.

How to store Coversyl Arginine

Keep out of the sight and reach of children. Keep container tightly closed, protect from mositure. 4

Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them. Stop taking the medicinal product and see a doctor immediately, if you experience any of the following side effects that can be serious: * swelling of the face, lips, mouth, tongue or throat, difficulty in breathing (angioedema) (See section 2 “Warnings and precautions”) (Uncommon - may affect up to 1 in 100 people), * severe dizziness or fainting due to low blood pressure (Common - may affect up to 1 in 10 people), * unusual fast or irregular heart beat, chest pain (angina) or heart attack (Very rare - may affect up to 1 in 10,000 people), * weakness of arms or legs, or problems speaking which could be a sign of a possible stroke (Very rare - may affect up to 1 in 10,000 people), * sudden wheeziness, chest pain, shortness of breath, or difficulty in breathing (bronchospasm) (Uncommon - may affect up to 1 in 100 people), * inflamed pancreas which may cause severe abdominal and back pain accompanied with feeling very unwell (Very rare - may affect up to 1 in 10,000 people), * yellowing of the skin or eyes (jaundice) which could be a sign of hepatitis (Very rare - may affect up to 1 in 10,000 people), * skin rash which often starts with red itchy patches on your face, arms or legs (erythema multiforme) (Very rare - may affect up to 1 in 10,000 people). Tell your doctor if you notice any of the following side effects: Common (may affect up to 1 in 10 people): * headache, * dizziness, * vertigo, * pins and needles, * vision disturbances, * tinnitus (sensation of noises in the ears), * cough, * shortness of breath (dyspnoea), * gastrointestinal disorders (nausea, vomiting, abdominal pain, taste disturbances, dyspepsia or difficulty of digestion, diarrhoea, constipation), * allergic reactions (such as skin rashes, itching), * muscle cramps, * feeling of weakness, Uncommon (may affect up to 1 in 100 people): * mood swings, * sleep disturbances, * dry mouth, * intense itching or severe skin rashes, * formation of blister clusters over the skin, * kidney problems, * impotence, * sweating, * excess of eosinophils (a type of white blood cells), * somnolence, * fainting, * palpitations, * tachycardia, * vasculitis (inflammation of blood vessels), * photosensitivity reaction (incre

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Important Notice: The Drugs. com international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

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Ficonax - ?Tu Colega Siempre En Linea, Ficonax

FICONAX

FICONAX TABLETAS Hipoglucemiante oral PISA, S. A. de C. V. LABORATORIOS .

- FORMA FARMACEUTICA Y FORMULACION - INDICACIONES TERAPEUTICAS - FARMACOCINETICA Y FARMACODINAMIA EN HUMANOS - CONTRAINDICACIONES - PRECAUCIONES GENERALES - PRECAUCIONES O RESTRICCIONES DE USO DURANTE EL EMBARAZO O LA LACTANCIA - REACCIONES SECUNDARIAS Y ADVERSAS - INTERACCIONES MEDICAMENTOSAS Y DE OTRO GENERO - ALTERACIONES DE PRUEBAS DE LABORATORIO - PRECAUCIONES Y RELACION CON EFECTOS DE CARCINOGENESIS, MUTAGENESIS, TERATOGENESIS Y SOBRE LA FERTILIDAD - DOSIS Y VIA DE ADMINISTRACION - SOBREDOSIFICACION O INGESTA ACCIDENTAL: MANIFESTACIONES Y MANEJO (ANTIDOTOS) - PRESENTACIONES - RECOMENDACIONES PARA ALMACENAMIENTO - LEYENDAS DE PROTECCION - NOMBRE DEL LABORATORIO Y DIRECCION - NUMERO DE REGISTRO DEL MEDICAMENTO

FORMA FARMACEUTICA Y FORMULACION:

Cada tableta contiene:

Clorhidrato de metformina. 850 mg 1 g

Excipiente c. b.p. 1 tableta 1 tableta

INDICACIONES TERAPEUTICAS: FICONAX* esta indicado en la diabetes mellitus tipo 2 (diabetes mellitus no insulino dependiente) que curse con obesidad exogena, en quienes se halla presentado falla primaria y secundaria a la restriccion calorica y al ejercicio y/o a la administracion de hipoglucemiantes orales.

FICONAX* se toma solo o en combinacion con sulfonilureas u otros hipoglucemiantes orales, obteniendo un mejor control glucemico y mejorando la concentracion lipidica en los pacientes que responden pobremente al control con dieta o hipoglucemiantes solos.

Ya que el mecanismo de accion de FICONAX* no estimula la liberacion de insulina a partir de las celulas beta del pancreas, puede utilizarse tambien en combinacion con la administracion exogena de insulina en aquellos pacientes que no responden al tratamiento con hipoglucemiantes orales. La utilizacion de la combinacion de insulina-metformina a proporcionado un buen control de la glucemia, disminuyendo los requerimientos de insulina.

Existen estudios en los que se ha comprobado que las pacientes con poliquistosis ovarica, tambien conocida como sindrome de ovarios poliquisticos cursan con resistencia a la insulina, por lo que metformina tambien se ha utilizado como parte del tratamiento de esta enfermedad.

FARMACOCINETICA Y FARMACODINAMIA EN HUMANOS: La biguanida metformina (dimetilbiguanida) fue introducida a la practica clinica en 1957 como un agente antihiperglucemiante oral para el tratamiento de la DMNID.

La metformina y otros agentes del tipo biguanida como fenformina y buformina son estructuralmente parecidos a la guanidina, esta es una sustancia activa contenida en las lilas francesas (Galega officinalis) que se utilizo como remedio oficial en Europa para el tratamiento de la diabetes.

La metformina sin embargo, difiere en su estructura quimica y perfil farmacologico, tanto de fenformina como de buformina y se continua utilizando ampliamente en muchos paises para el manejo de la DMNID.

Aunque la metformina ha sido utilizada por mas de 30 anos, su mecanismo de accion aun no esta plenamente esclarecido. Los estudios farmacologicos muestran que al parecer actua favoreciendo la sensibilidad de receptores celulares perifericos y hepatico a la insulina, ademas de retardar la absorcion de glucosa a nivel gastrointestinal. La metformina tiene un efecto benefico en comparacion con otras biguanidas, ya que no incrementa los niveles plasmaticos de insulina e incluso reduce la hiperinsulinemia.

La metformina reduce los niveles de glucosa en pacientes con DMNID, ademas, a diferencia de las sulfonilureas no causa una reduccion de los niveles de glucosa en sujetos normoglucemicos.

Su efecto antihiperglucemiante es principalmente debido a su mecanismo de accion en sitios extrapancreaticos, potencializando los efectos metabolicos de la insulina en los tejidos perifericos, esto resulta en un transporte incrementado de la glucosa al interior de la celula, un aumento de la oxidacion de la glucosa y un incremento en la incorporacion del glucogeno.

La evidente mejoria en la disposicion de la glucosa inducida por metformina se atribuye principalmente al incremento del metabolismo no oxidativo de la glucosa. En estudios con metformina a dosis de 1,000 a 2,550 mg/dia por periodos hasta de 12 semanas en pacientes diabeticos y no diabeticos se demostro aumento en la disposicion de la glucosa.

El metabolismo no oxidativo incluye la formacion del glucogeno, la conversion de glucosa a lactato y la incorporacion de la glucosa dentro de los trigliceridos.

La metformina administrada a razon de 1,000 a 2,550 mg/dia hasta por 3 meses redujo significativamente la produccion hepatica de glucosa basal de 9 hasta 30% comparado contra placebo. Se dice que el exceso en la produccion hepatica de glucosa basal es un factor importante en la etiologia de la DMNID.

La supresion de la produccion hepatica de glucosa basal por la metformina fue propuesta como una causa de reduccion de la hiperglucemia en DMNID mediada particularmente por la reduccion de los acidos grasos libres y la oxidacion de lipidos.

La absorcion de metformina despues de su ingestion oral es lenta e incompleta a nivel gastrointestinal, en especial en el intestino delgado, donde se calcula que se logra 6 horas despues de su administracion en ausencia de alimentos y en presencia de alimentos se retrasa un poco mas (concentracion maxima de 40%), ya que disminuye su area de absorcion (area bajo la curva concentracion-tiempo de 25%). Tiene una biodisponibilidad de 50 a 60%.

La metformina se distribuye rapidamente y tiene un volumen de distribucion promedio de 654 ± 358 mg/lt. seguido de una dosis oral de 850 mg. Los principales sitios de concentracion y acumulacion son la mucosa intestinal y las glandulas salivales. La metformina no se une a proteinas y no es metabolizada. Su vida media plasmatica es de 6.2 horas en promedio con una vida media inicial de 1.7 a 3 horas y con una vida media de eliminacion final de 9 a 17 horas, su concentracion plasmatica en su estado activo es de aproximadamente 1 a 2 mg/ml (6.04 a 12.08 mmol/lt.), su eliminacion es por via renal principalmente. Hasta 90% de la dosis administrada se excreta sin cambios por la orina y su depuracion a nivel renal es de 450 a 513 ml/minuto, por heces se elimina hasta 30% de la dosis administrada. En pacientes con dialisis y hemodialisis con una depuracion renal de 170 ml/minuto se previene la acumulacion de metformina.

CONTRAINDICACIONES: La metformina esta contraindicada en pacientes con:

q Insuficiencia renal y/o trastornos de la funcion renal.

q Enfermedad hepatica conocida.

q Pacientes con antecedentes de acidosis lactica (de cualquier causa).

q Dano cardiaco.

q Enfermedad pulmonar obstructiva cronica (EPOC).

q Acidosis metabolica, incluyendo cetoacidosis diabetica con o sin coma.

q Hipersensibilidad conocida a los componentes de la formula.

PRECAUCIONES GENERALES: La metformina se ha asociado a un riesgo de acidosis lactica que puede llegar a ser fatal en aquellos pacientes susceptibles que presenten o hayan presentado enfermedad hepatica, dano cardiaco, enfermedad pulmonar obstructiva cronica o con antecedente de acidosis lactica de cualquier indole.

Las biguanidas estan contraindicadas en pacientes con coma diabetico o cetoacidosis, en aquellos pacientes con infeccion severa, traumatismos o en personas con antecedentes de alcoholismo cronico.

Sindrome de malabsorcion y anemia megaloblastica por deficiencia de vitamina B12 y folato.

Puede temporalmente retrasar la eliminacion de material de contraste yodado parenteral, ya que el uso de estos productos puede causar una alteracion aguda de la funcion renal (por ejemplo, urograma I. V. colangiografia I. V. etc.).

Asi mismo, metformina, al igual que otros antidiabeticos, no deben utilizarse en pacientes que cursen con hipoglucemia.

Los pacientes con diabetes tipo 2 que cursen por situaciones de estres tales como fiebre, cirugia, traumatismos o infecciones sistemicas pueden requerir la suspension de los antidiabeticos orales y hacer una transferencia temporal a tratamiento con insulina.

PRECAUCIONES O RESTRICCIONES DE USO DURANTE EL EMBARAZO O LA LACTANCIA:

Embarazo: La seguridad de metformina no esta establecida en mujeres embarazadas. En estudios realizados en ratas y conejos machos o hembras a dosis mayores de 600 mg/kg/dia, dos veces mas la dosis maxima recomendada en humanos, la metformina no presento teratogenicidad ni alteracion de la fertilidad.

Se recomienda para el control de la glucosa sanguinea durante el embarazo dieta sola o combinacion de dieta e insulina, mientras el uso de todos los antidiabeticos orales estan descartados. El uso de insulina en la diabetes gestacional permite el mantenimiento de niveles de glucosa sanguinea lo mas cercano posible a lo normal.

Cualquier prescripcion de metformina durante el embarazo es valorando el riesgo-beneficio y depende del medico tratante.

Lactancia: Estudios en ratas lactantes muestran que la metformina se excreta por la leche y los niveles son comparables a los del plasma.

Estudios similares en humanos no reportaron sustancia activa en los conductos de las madres lactantes, su uso queda bajo la responsabilidad del medico.

REACCIONES SECUNDARIAS Y ADVERSAS: Las reacciones secundarias que se han reportado con el uso de metformina son del tipo gastrointestinal como: diarrea, nauseas, vomito, sensacion de plenitud abdominal, flatulencia, sabor metalico y anorexia. Se presentan en 30% aproximadamente, en aquellos pacientes con monoterapia y que van iniciando su tratamiento.

Estos sintomas son generalmente transitorios y se resuelven espontaneamente durante el transcurso del tratamiento, no es necesario suspenderlo y en ocasiones solo se necesita incrementar la dosis lentamente.

Acidosis lactica: Ocurre usualmente en pacientes con factores predisponentes, sobre todo en pacientes con insuficiencia renal.

En raras ocasiones puede asociarse a sindrome de malabsorcion y anemia megaloblastica.

Hipersensibilidad: Vasculitis y pneumonitis.

INTERACCIONES MEDICAMENTOSAS Y DE OTRO GENERO: Los corticosteroides, hormonas tiroideas, anticonceptivos, diureticos y simpaticomimeticos, pueden alterar la tolerancia a la glucosa y reducir el efecto normoglicemiante de metformina.

Al administrarse conjuntamente con cimetidina puede incrementar su concentracion plasmatica y aumentar el riesgo de acidosis lactica. Se recomienda tener precaucion en aquellos pacientes que ingieren medicamentos cationicos (por ejemplo, amilorida, digoxina, morfina, procainamida, ranitidina, trimetropima y vancomicina), ya que se eliminan por secrecion tubular renal y pueden potenciar el efecto de metformina.

El clorhidrato de metformina no causa hipoglicemia por si sola, sin embargo, se debe tener especial cuidado cuando se administra en combinacion con otros hipoglucemiantes orales (sulfonilureas).

ALTERACIONES DE PRUEBAS DE LABORATORIO:

Resultados con prueba diagnostica: Cetonas urinarias (pueden producir falsos positivos).

Valores en pruebas de laboratorio y fisiologicas: Generalmente las concentraciones de colesterol, lipoproteinas de baja densidad y trigliceridos pueden ser disminuidos o mantenerse igual en los usuarios de metformina. Esta es la idea que se tiene independientemente de los efectos hipoglucemiantes de metformina; puede producir supresion de la oxidacion acida de la grasa libre y la oxidacion lipidica o reduccion en los trigliceridos conteniendo fracciones de lipoproteinas de baja densidad y lipoproteinas de muy baja densidad.

Puede ocurrir mala absorcion de la vitamina B12 y en casos aislados llevar al desarrollo de anemia megaloblastica.

Lactato serico en ayuno: Puede incrementar a un nivel arriba de lo normal 2 mEq/lt. [2 mmol/lt.] o no mostrar cambios a dosis terapeuticas aunque el curso es desconocido y cualquier pequeno incremento se piensa es debido al metabolismo de la glucosa en el higado y no en el musculo esqueletico.

PRECAUCIONES Y RELACION CON EFECTOS DE CARCINOGENESIS, MUTAGENESIS, TERATOGENESIS Y SOBRE LA FERTILIDAD: Estudios en ratas y ratones no mostraron evidencias de carcinogenesis.

No se encontro evidencia de mutagenesis potencial de metformina, con la prueba de AMES.

La fertilidad en ratas hembras y machos no se afecto aun a dos veces mas la dosis maxima recomendada para humanos sobre superficie corporal total.

Teratogenesis: No se encontraron anormalidades en estudios con ratas albinas.

DOSIS Y VIA DE ADMINISTRACION: La metformina es un hipoglucemiante oral de la familia de las biguanidas.

Se administra por via oral en el tratamiento de la DMNID a una dosis inicial de 500 o 850 mg dos veces al dia con o sin alimentos, aumentando gradualmente hasta 3 veces al dia sin exceder de 3 g/dia.

SOBREDOSIFICACION O INGESTA ACCIDENTAL: MANIFESTACIONES Y MANEJO (ANTIDOTOS): La metformina se administro con dosis de hasta 85 g/dia, sin encontrar problemas relacionados con la seguridad del medicamento. Sin embargo, la sobredosis con hipoglucemiantes orales puede dar como resultado hipoglucemia, que se manifiesta por aparicion de astenia, confusion, palpitaciones, diaforesis y vomitos, se recomienda tener precaucion al combinarse con sulfonilureas o meglitinidas, o en aquellos pacientes con ingesta baja de calorias en la dieta. En los casos de hipoglucemia leve, bastara con reposo y administracion por via oral de soluciones con glucosa o azucar. En casos de hipoglucemia severa pueden aparecer alteraciones neurologicas manifestadas por crisis convulsivas, confusion y coma. El tratamiento incluye la administracion intravenosa de solucion glucosada al 50% seguida de una infusion intravenosa de solucion glucosada al 10% a una velocidad que logre mantener los niveles de glucosa por arriba de 100 mg/dl. El paciente debe permanecer hospitalizado y monitorizado estrechamente cuando menos 24 a 48 horas. Puede llegar a producir acidosis lactica en aquellos pacientes con falla renal o hepatica.

Caja con 30 tabletas de 850 mg cada una.

Caja con 30 tabletas de 1 g cada una.

RECOMENDACIONES PARA ALMACENAMIENTO: Conservese a temperatura ambiente a no mas de 30°C y en lugar seco.

LEYENDAS DE PROTECCION: Literatura exclusiva para medicos. Su venta requiere receta medica. No se deje al alcance de los ninos. No se administre este medicamento sin leer el instructivo impreso en la caja. El uso de este medicamento durante el embarazo y la lactancia queda bajo la responsabilidad del medico.

NOMBRE DEL LABORATORIO Y DIRECCION: Hecho en Mexico por: LABORATORIOS PISA, S. A. de C. V. Calle 7 No. 1308 Zona Industrial 44940 Guadalajara, Jal. Mexico * Marca registrada

NUMERO DE REGISTRO DEL MEDICAMENTO: Reg. Num. 299M2000, S. S.A. EEAR-04361202613/RM2004/IPPA

Crisasma, Crisasma

Allergies - Crisasma (Brand name: quibron-t)

Preventing and treating symptoms and blockage of airway due to asthma or other lung diseases (eg, emphysema, bronchitis). It may also be used for other conditions as determined by your doctor.

Quibron-T is a xanthine derivative. It works by relaxing the muscle around the airways in the lungs, which allows them to widen and makes breathing easier. It also improves contraction of the diaphragm (the major breathing muscle) and decreases the response of the airways to irritants.

Use Quibron-T as directed by your doctor. Check the label on the medicine for exact dosing instructions. This medicine may be taken on an empty stomach or with food. Try to take this medicine every day at evenly spaced times. If you have questions about the best time to take it, ask your pharmacist.

Some foods may change the effectiveness or increase the side effects of Quibron-T. Talk to your doctor about how you should take Quibron-T with regard to food. Do not suddenly change your diet or eating habits without first checking with your doctor. Take Quibron-T at evenly spaced times throughout the day. Taking Quibron-T at the same time each day will help you remember to take it. Contact your doctor with any questions or concerns about the best way to take Quibron-T. If you miss a dose of Quibron-T, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Quibron-T.

Use Quibron-T as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Store at room temperature away from sunlight and moisture.

Active Ingredient: Theophylline

Do NOT use Quibron-T if:

you are allergic to any ingredient in Quibron-T, similar medicines (eg, aminophylline), or xanthines (eg, caffeine, chocolate)

you are using large amounts of other products that contain xanthine (such as chocolate or caffeinated drinks)

you are taking dipyridamole intravenously (IV), febuxostat, halothane, or St. John's wort

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Quibron-T. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of heart problems (eg, congestive heart failure, cor pulmonale), an irregular heartbeat, liver problems (eg, cirrhosis, hepatitis), viral infection, thyroid problems, increased acid levels in the body, brain or nerve problems, or seizures (eg, epilepsy)

if you are in shock or have a fever, an ulcer, a severe infection, cystic fibrosis, or fluid in the lungs (pulmonary edema)

if you smoke, are stopping or starting smoking, or are exposed to the smoke from cigarettes or marijuana

if you are in the last 3 months of pregnancy

Important safety information:

Drinking alcohol may increase the risk of side effects of Quibron-T. Talk to your doctor before drinking alcohol while you are taking Quibron-T.

Tell your doctor or dentist that you take Quibron-T before you receive any medical or dental care, emergency care, or surgery.

Do not take more than the recommended dose or use more often than prescribed without checking with your doctor. If your symptoms become worse, contact your doctor.

Carry an ID card at all times that says you take Quibron-T.

Avoid large amounts of food or drink that have caffeine (eg, coffee, tea, cocoa, cola, chocolate).

Notify your doctor if you develop a new illness, especially if it is accompanied by fever; if a chronic illness becomes worse; or if you start or stop smoking cigarettes or marijuana.

Tell your doctor if another doctor prescribes a new medicine or tells you to stop using a medicine that you have already been taking. Tell your doctor if you start or stop any medicine, either prescription or over the counter.

Quibron-T will not stop an asthma attack once one has started. Be sure to always carry appropriate rescue medicine (eg, bronchodilator inhaler) with you in case of an asthma attack.

If you have more than one doctor, be sure to tell each of your doctors that you are taking Quibron-T.

Diabetes patients - Quibron-T may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

Quibron-T may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Quibron-T.

Lab tests, including blood theophylline levels, may be performed while you use Quibron-T. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Quibron-T with caution in the ELDERLY; they may be more sensitive to its effects.

Caution is advised when using Quibron-T in CHILDREN, especially children younger than 1 year old; they may be more sensitive to its effects. Children may be more likely to experience mild, temporary behavior changes.

PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor.

You will need to discuss the benefits and risks of using Quibron-T while you are pregnant. Quibron-T is found in breast milk. If you are or will be breast-feeding while you use Quibron-T, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Irritability; mild, temporary caffeine-like effects (eg, headache, nausea, diarrhea, trouble sleeping); mild, temporary changes in behavior; restlessness; temporary increased urination.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; dizziness; fast breathing; fast or irregular heartbeat; heart rhythm problems; seizures; severe or persistent nausea, diarrhea, or headache; sleeplessness; tremors; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects.

Preventing and treating symptoms and blockage of airway due to asthma or other lung diseases (eg, emphysema, bronchitis). It may also be used for other conditions as determined by your doctor.

Quibron-T is a xanthine derivative. It works by relaxing the muscle around the airways in the lungs, which allows them to widen and makes breathing easier. It also improves contraction of the diaphragm (the major breathing muscle) and decreases the response of the airways to irritants.

Use Quibron-T as directed by your doctor. Check the label on the medicine for exact dosing instructions. This medicine may be taken on an empty stomach or with food. Try to take this medicine every day at evenly spaced times. If you have questions about the best time to take it, ask your pharmacist.

Some foods may change the effectiveness or increase the side effects of Quibron-T. Talk to your doctor about how you should take Quibron-T with regard to food. Do not suddenly change your diet or eating habits without first checking with your doctor. Take Quibron-T at evenly spaced times throughout the day. Taking Quibron-T at the same time each day will help you remember to take it. Contact your doctor with any questions or concerns about the best way to take Quibron-T. If you miss a dose of Quibron-T, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Quibron-T.

Use Quibron-T as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Store at room temperature away from sunlight and moisture.

Active Ingredient: Theophylline

Do NOT use Quibron-T if:

you are allergic to any ingredient in Quibron-T, similar medicines (eg, aminophylline), or xanthines (eg, caffeine, chocolate)

you are using large amounts of other products that contain xanthine (such as chocolate or caffeinated drinks)

you are taking dipyridamole intravenously (IV), febuxostat, halothane, or St. John's wort

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Quibron-T. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of heart problems (eg, congestive heart failure, cor pulmonale), an irregular heartbeat, liver problems (eg, cirrhosis, hepatitis), viral infection, thyroid problems, increased acid levels in the body, brain or nerve problems, or seizures (eg, epilepsy)

if you are in shock or have a fever, an ulcer, a severe infection, cystic fibrosis, or fluid in the lungs (pulmonary edema)

if you smoke, are stopping or starting smoking, or are exposed to the smoke from cigarettes or marijuana

if you are in the last 3 months of pregnancy

Important safety information:

Drinking alcohol may increase the risk of side effects of Quibron-T. Talk to your doctor before drinking alcohol while you are taking Quibron-T.

Tell your doctor or dentist that you take Quibron-T before you receive any medical or dental care, emergency care, or surgery.

Do not take more than the recommended dose or use more often than prescribed without checking with your doctor. If your symptoms become worse, contact your doctor.

Carry an ID card at all times that says you take Quibron-T.

Avoid large amounts of food or drink that have caffeine (eg, coffee, tea, cocoa, cola, chocolate).

Notify your doctor if you develop a new illness, especially if it is accompanied by fever; if a chronic illness becomes worse; or if you start or stop smoking cigarettes or marijuana.

Tell your doctor if another doctor prescribes a new medicine or tells you to stop using a medicine that you have already been taking. Tell your doctor if you start or stop any medicine, either prescription or over the counter.

Quibron-T will not stop an asthma attack once one has started. Be sure to always carry appropriate rescue medicine (eg, bronchodilator inhaler) with you in case of an asthma attack.

If you have more than one doctor, be sure to tell each of your doctors that you are taking Quibron-T.

Diabetes patients - Quibron-T may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

Quibron-T may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Quibron-T.

Lab tests, including blood theophylline levels, may be performed while you use Quibron-T. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Quibron-T with caution in the ELDERLY; they may be more sensitive to its effects.

Caution is advised when using Quibron-T in CHILDREN, especially children younger than 1 year old; they may be more sensitive to its effects. Children may be more likely to experience mild, temporary behavior changes.

PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor.

You will need to discuss the benefits and risks of using Quibron-T while you are pregnant. Quibron-T is found in breast milk. If you are or will be breast-feeding while you use Quibron-T, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Irritability; mild, temporary caffeine-like effects (eg, headache, nausea, diarrhea, trouble sleeping); mild, temporary changes in behavior; restlessness; temporary increased urination.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; dizziness; fast breathing; fast or irregular heartbeat; heart rhythm problems; seizures; severe or persistent nausea, diarrhea, or headache; sleeplessness; tremors; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects.

Clozapine Uses, Dosage - Side Effects, Clozapin

Clozapine

Clozapine is an antipsychotic medication. It works by changing the actions of chemicals in the brain.

Clozapine is used to treat severe schizophrenia. or to reduce the risk of suicidal behavior in people with schizophrenia or similar disorders.

Clozapine is available only from a certified pharmacy under a special program. You must be registered in the program and agree to undergo frequent blood tests.

Important information

You should not take clozapine if you have ever developed a severe infection or severe allergic reaction while taking this medicine. Serious and sometimes fatal infections may occur during treatment.

Call your doctor right away if you have signs of infection (sudden weakness or ill feeling, fever, sore throat) .

Clozapine can cause severe dizziness, slow heartbeats, fainting, or seizures. Do not take more of this medicine than recommended .

Call your doctor at once if you have chest pain, trouble breathing, fluttering in your chest, or if you feel like you might pass out.

Clozapine is not approved for use in psychotic conditions related to dementia. This medicine may increase the risk of death in older adults with dementia-related conditions.

Clozapine is available only from a certified pharmacy under a special program.

Before taking this medicine

You should not take clozapine if you have ever developed a severe infection or severe allergic reaction while taking this medicine.

Clozapine is not approved for use in psychotic conditions related to dementia. Clozapine may increase the risk of death in older adults with dementia-related conditions.

To make sure clozapine is safe for you, tell your doctor if you have:

heart disease, high blood pressure, or history of heart attack or stroke (including "mini-stroke");

a personal or family history of long QT syndrome;

an electrolyte imbalance (such as low levels of potassium or magnesium in your blood);

a history of seizures, head injury, or brain tumor;

diabetes, or risk factors such as being overweight or having a family history of diabetes;

high cholesterol or triglycerides;

a bowel obstruction called paralytic ileus;

liver or kidney disease;

an enlarged prostate or urination problems;

if you are malnourished or dehydrated; or

Tell your doctor if you are pregnant or plan to become pregnant during treatment. Taking antipsychotic medication during the last 3 months of pregnancy may cause problems in the newborn . such as withdrawal symptoms, breathing problems, feeding problems, fussiness, tremors, and limp or stiff muscles. However, you may have withdrawal symptoms or other problems if you stop taking your medicine during pregnancy. If you become pregnant while taking clozapine, do not stop taking it without your doctor's advice.

Clozapine can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are taking this medicine.

How should I take clozapine?

Take clozapine exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Clozapine can be taken with or without food.

The orally-disintegrating tablet (FazaClo) can be taken without water. Keep the tablet in its blister pack until you are ready to take it. Open the package and peel back the foil. Do not push a tablet through the foil or you may damage the tablet. Use dry hands to remove the tablet and place it in your mouth. Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing. If desired, you may drink liquid to help swallow the dissolved tablet.

If your doctor has prescribed one-half of an orally-disintegrating tablet, you will need to break the tablet in half. Throw the other half away. Do not save it for later use.

Clozapine can lower blood cells that help your body fight infections, especially in women and older adults, and in people who are malnourished or have serious medical problems. This can make it easier for you to develop a serious or life-threatening infection. Your blood will need to be tested often. Your future treatments may be delayed based on the results of these tests.

If you need surgery, tell the surgeon ahead of time that you are using clozapine. You may need to stop using the medicine for a short time.

You should not stop using clozapine suddenly or you could have unpleasant withdrawal symptoms. Follow your doctor's instructions about tapering your dose.

Clozapine can have long lasting effects on your body. You may need frequent medical tests for a short time after you stop using this medicine.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. If you miss taking clozapine for more than 2 days in a row, call your doctor before you start taking it again.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking clozapine?

Clozapine can cause severe dizziness, slow heartbeats, fainting, or seizures. Do not take more of this medicine than recommended . Be careful if you drive or do anything that requires you to be alert. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Avoid drinking alcohol. It can increase some of the side effects of clozapine.

Clozapine side effects

Get emergency medical help if you have signs of an allergic reaction to clozapine: hives, skin pain, rash that spreads and causes blistering or peeling; difficult breathing; swelling of your face, lips, tongue, or throat.

Serious and sometimes fatal infections may occur during treatment with clozapine. Call your doctor right away if you have signs of infection such as: sudden weakness or ill feeling; fever, swollen glands, sore throat, flu symptoms; or mouth sores, red or swollen gums, and trouble swallowing.

High doses or long-term use of clozapine can cause a serious movement disorder that may not be reversible. Symptoms of this disorder include uncontrollable muscle movements of your lips, tongue, eyes, face, arms, or legs. The longer you take this medicine, the more likely you are to develop a serious movement disorder. The risk of this side effect is higher in women and older adults.

Also call your doctor at once if you have:

headache with chest pain and severe dizziness, pounding heartbeats or fluttering in your chest;

a light-headed feeling, like you might pass out;

sudden cough, rapid breathing, coughing up blood;

tight feeling in your neck or jaw, twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs;

a seizure (black-out or convulsions);

swelling, rapid weight gain, little or no urinating;

severe nervous system reaction - very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out;

high blood sugar - increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss; or

signs of inflammation in your body - easy bruising or bleeding, severe tingling or numbness, muscle weakness, upper stomach pain, jaundice (yellowing of the skin or eyes), chest pain, new or worsening cough, trouble breathing.

Common clozapine side effects may include:

tremor, dizziness, spinning sensation;

fast heart rate;

dry mouth, or increased salivation;

blurred vision; or

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Clozapine dosing information

Usual Adult Dose for Schizophrenia:

Initial dose: 12.5 mg orally once or twice a day Titration and Maintenance: May increase total daily dose in increments of 25 mg to 50 mg per day to a target dose of 300 mg to 450 mg per day (administered in divided doses) by the end of week 2. Subsequent dose increases can be in increments of up to 100 mg once or twice weekly. Maximum dose: 900 mg per day

Comments: - The absolute neutrophil count (ANC) must be 2000/mm3 or greater and WBC count 3500 mm3 or greater, prior to initiating treatment; the ANC and WBC must be monitored regularly during therapy. - A low starting dose, gradual titration, and divided doses are necessary to minimize the risk of orthostatic hypotension, bradycardia, and syncope. - When therapy is interrupted for 2 or more days, re-initiate with 12.5 mg once or twice a day; based on tolerability, a dose that is restarted may be increased to a previously therapeutic dose more quickly than it was for initial treatment.

Uses: - For the treatment of severely ill patients with schizophrenia who fail to respond adequately to standard antipsychotic treatment. - To reduce the risk of recurrent suicidal behavior in patients with schizophrenia or schizoaffective disorder, who are judged to be at chronic risk for re-experiencing suicidal behavior, based on history and recent clinical state.

What other drugs will affect clozapine?

Clozapine can cause a serious heart problem, especially if you use certain medicines at the same time. Tell your doctor about all medicines you use, and those you start or stop using during your treatment.

Taking clozapine with other drugs that make you sleepy or slow your breathing can cause dangerous or life-threatening side effects. Ask your doctor before taking this medicine with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.

Many drugs can interact with clozapine. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any you start or stop using, especially:

dolasetron, methadone, probucol, tacrolimus;

an antibiotic - ciprofloxacin, enoxacin, erythromycin, pentamidine, rifampin;

an antidepressant - citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline;

anti-malaria medication - mefloquine, halofantrine;

heart rhythm medicine - amiodarone, encainide, flecainide, procainamide, propafenone, quinidine, sotalol;

medicine to treat a psychiatric disorder - chlorpromazine, droperidol, haloperidol, iloperidone, pimozide, thioridazine, ziprasidone; or

seizure medication - carbamazepine, phenytoin.

This list is not complete and many other drugs can interact with clozapine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.

More about clozapine

Consumer resources

Professional resources

Related treatment guides

Where can I get more information?

Your pharmacist can provide more information about clozapine.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use clozapine only for the indication prescribed.

Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2016 Cerner Multum, Inc. Version: 16.01. Revision Date: 2015-11-16, 3:47:23 PM.

Drug Status

Medilax News - Updates, Medilax

Medilax News

Posted 8 Jun 2016 by Drugs. com

-- Laxatives can have unpleasant side effects, especially when overused. The American Academy of Family Physicians says possible problems associated with laxative use include: Abdominal cramps or nausea. Gas, diarrhea or bloating. Electrolyte imbalance, which can affect the muscles, nerves and organs. Those most at risk include children and people with kidney disease or diabetes. Muscle weakness or muscle spasms. Fatigue, confusion, headache or vomiting. Read more

Posted 8 Oct 2014 by Drugs. com

WEDNESDAY, Oct. 8, 2014 – A new study suggests that the type of laxative a person takes might be a factor in their odds for colon cancer. The research indicates that fiber-based laxatives are associated with a lower risk of colorectal cancer, while non-fiber laxatives are linked with a higher risk. The study could only show an association between laxative types and colon cancer risk, it could not prove cause-and-effect, and experts stress that more study is needed. Still, the researchers believe the findings are important because about 20 percent of Americans use laxatives. According to a team led by Jessica Citronberg, a predoctoral fellow at Fred Hutchinson Cancer Research Center in Seattle, non-fiber laxatives are the most widely used in the United States and work by forcing the colon to contract. On the other hand, fiber-based laxatives boost the water content and bulk of the stool. Read more

Posted 28 Jan 2013 by Drugs. com

MONDAY, Jan. 28 – Some treatments are more effective than others for relieving constipation in seniors, according to a new review. And laxatives aren't always enough, researchers say. Constipation is common in seniors and can have serious health consequences and affect quality of life. Excessive straining in frail elderly people can cause them to faint and put them at risk of injury or falling, or restrict blood flow to the heart and brain. Chronic constipation can lead to fecal impaction, a large lump of hard stool that remains stuck in the rectum. Fecal impaction can cause nausea, pain and loss of appetite. "Given the growing proportion of older adults in North America, effective management of constipation by health care professionals will be increasingly necessary," Dr. Dov Gandell, of Sunnybrook Health Sciences Centre in Toronto, and colleagues wrote in an article appearing Jan. 28. Read more

Posted 16 Aug 2011 by Drugs. com

TUESDAY, Aug. 16 – Many women in the United States continue to use a Chinese weight-loss supplement that's been recalled due to dangerous ingredients, a new study indicates. Pai You Guo contains the pharmaceuticals sibutramine and phenolphthalein, both of which are banned in the United States because they increase the risk of heart attack, stroke and cancer. The U. S. Food and Drug Administration announced a recall of Pai You Guo in 2009 but it appears to have had little effect on the number of women using the weight-loss product, this study suggests. Harvard Medical School researchers surveyed more than 550 women who were born in Brazil and live in greater Boston and found that nearly one-quarter of them have used or currently use Pai You Guo. Most of the women using the supplement have experienced side effects such as insomnia, palpitations, fainting and addiction to the product. The. Read more

Posted 17 May 2010 by Drugs. com

-- Laxatives are medications usually purchased over-the-counter to help treat constipation. The American Academy of Family Physicians says side effects are rare if laxatives are taken as their labels direct, but sometimes they can trigger: Diarrhea. Nausea. Cramps. Gas. Bloating. Read more

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Gasprid, Gasprid

Cisapride

Click for further information on drug naming conventions and International Nonproprietary Names .

Important Notice: The Drugs. com international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

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Fluxus, Fluxus

Fluxus

Lisa S. Wainwright

Fluxus , a loose international group of artists, poets, and musicians whose only shared impulse was to integrate life into art through the use of found events, sounds, and materials, thereby bringing about social and economic change in the art world. More than 50 artists were associated with Fluxus, many producing a periodical anthologizing the latest experiments across the world in art and antiart, music and antimusic, and poetry and antipoetry and many taking part for the sheer collaboration opportunities and the built-in audience. Fluxus involved artists from around the world, including the Americans Dick Higgins and Alison Knowles, the Frenchman Ben Vautrier, the Korean artist Nam June Paik. and the German artist Wolf Vostell.

During Yoko Ono’s Sky Piece to Jesus Christ (1965), at Carnegie …

Truman Moore—Time Life Pictures/Getty Images

The name Fluxus, meant to suggest both “flow” and “effluent,” was coined by Fluxus founder George Maciunas (1931–78), a Lithuanian American designer and “cultural entrepreneur.” Maciunas used the word fluxus to describe a wide range of his activities, from a published call for a common front of artists against culture to a New York artists’ housing association, as well as a publishing concern that produced ephemeral interactive multiples and staged live events called Happenings that were precursors to performance art. video art. and other progressive art forms.

In its early years, from 1962 to 1966, Fluxus fused conceptual art. minimalism. new music, poetry, and chance-based work into an intermedia phenomenon, identifiable more through its irreverent attitude toward art than through the use of any distinct style. Utilizing humour—in the spirit of Dada — and everyday materials and experiences, Fluxus created original and often surprising objects and events. The Fluxus event, sometimes a minimal live gesture initially presented as part of a concert or a poetry reading, was researched and developed in part from ideas collected by the American experimental musician La Monte Young and published by him and the American poet and playwright Jackson Mac Low in 1963 as An Anthology of Chance Operations… . This publication—which collected “chance operations, concept art, anti-art, indeterminacy, plans of action, diagrams, music, dance constructions, improvisation, meaningless work, natural disasters, compositions, mathematics, essays, [and] poetry”—was designed by Maciunas and formed much of the material for his “Festum Fluxorum,” a European tour of 1962–63 during which Fluxus became an official movement and its international character was confirmed.

From 1964 Maciunas designed, produced, and promoted hundreds of multiples: a remarkable range of objects from tiny books of compositions to uniquely altered attache cases with compartments full of games in small plastic boxes, plus films, records, jokes, miniature environments, posters, and charts using imagery publicly available from the New York Public Library. All Fluxus production was driven by a utilitarian philosophy in which colour, scale, material, and font were secondary to affordability and available space—a format that brought coherence to the otherwise heterogeneous Fluxus style. More than 30 individuals, from Christo to Yoko Ono. collaborated with Maciunas, who interpreted their ideas, whether for a chess set or for an apron, into multiple forms. Produced on demand by hand, using volunteer labour and the cheapest material, these provocative and amusing items were deliberately ephemeral, inexpensive, and intended for use rather than display.

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Fluxus

Introduction

Founded in 1960 by the Lithuanian/American artist George Maciunas, Fluxus began as a small but international network of artists and composers who challenged accepted ideas about what art is. It characterised itself as a shared attitude rather than a movement. Rooted in experimental music, it was named after a magazine which featured the work of musicians and artists centred around avant-garde composer John Cage .

Fluxus had no single unifying style. Its artists used a range of media and processes adopting a ‘do-it-yourself’ attitude to creative activity, often staging random performances and using whatever materials were at hand to make art. Seeing themselves as an alternative to academic art and music, Fluxus was a democratic form of creativity open to anyone. Collaborations were encouraged between artists and across artforms, and also with the audience or spectator. It valued simplicity and anti-commercialism, with chance and accident playing a big part in the creation of works, and humour also being an important element.

The first Fluxus event was staged in 1961 at the AG Gallery in New York and was followed by festivals in Europe in 1962. The major centres of Fluxus activity were New York, Germany and Japan.

Almost every avant-garde artist of the time took part in Fluxus, including Joseph Beuys. Dick Higgins, Alice Hutchins, Yoko Ono. Nam June Paik. Ben Vautier, Robert Watts, Benjamin Patterson and Emmett Williams.

Explore Fluxus actions and performances in these fascinating photographs from Tate’s Archive:

Ben Vautier performing La Monte Young, 1961

Inspiration and influence

The Latin word Fluxus means flowing, in English a flux is a flowing out. Fluxus founder Maciunas said that the purpose of Fluxus was to ‘promote a revolutionary flood and tide in art, promote living art, anti-art’. This has strong echoes of dada. an early twentieth century art movement which aimed to destroy traditional values in art and create a new art to replace the old.

Fluxus played an important role in opening up the definitions of what art can be. It has profoundly influenced the nature of art production since the 1960s, which has seen a diverse range of art forms and approaches existing and flourishing side-by-side. (See for example conceptual art. performance art. film & video art and postmodernism ).

Fluxus artists in focus: Nam June Paik and Joseph Beuys

Nam June Paik: Father of video and media art

Curator of the 2011 Nam June Paik exhibition at Tate Liverpool provides an introduction to the importance and influence of the artist’s work:

Nam June Paik was born in Seoul in 1932 but his family fled to Japan during the Korean War where Paik studied music and aesthetics at the University of Tokyo. His passion for experimental music led him to Germany, at that time a centre for avant-garde music and there he worked closely with Karlheinz Stockhausen. He also met John Cage whose ideas on music and performance further inspired him to experiment with everyday sounds in his compositions.

Tateshots: Nam June Paik Watch as Nam June Paik’s nephew Ken Hakuta provides some fascinating personal glimpses into the life and art of his unconventional uncle…

Audio Arts: Volume 9 No 4 This interview with Nam June Paik was recorded in London during his exhibition Video Works 1963–88, at the Hayward Gallery, late in 1988. In it he discusses some of the important influences on his work and life.

John Lennon, Yoko Ono, Nam June Paik and Shuya Abe at the Galeria Bonino, New York, 23 November 1971

Photo: Tom Haar Courtesy Kunsthalle Bremen © The Estate of Nam June Paik.

When the future was now Discover more about Nam June Paik’s remarkable work in this Tate Etc. article about the early decades of his life.

Nam June Paik: Room Guide Explore the online guide to Tate Liverpool’s 2011 exhibition for a more detailed look at Nam June Paik’s ideas, work and influences.

Joseph Beuys: Mythmaker and visionary

Joseph Beuys was a sculptor, creator of action-performances, political leader and teacher. In line with the democratic spirit of Fluxus he extended the definition of art, suggesting that ‘everyone is an artist’. He also believed that art had the power to shape a better society and developed the idea of social sculpture as the ultimate, universal work of art, which he claimed could play a creative, participatory role in society and politics.

Watch fascinating archival film clips of Joesph Beuys performing lectures at Tate and the Whitechapel gallery:

The legacy of a myth maker This Tate Etc. article explores Beuys’s influence, looking at how contemporary artists have both borrowed from and developed his approach.

Joseph Beuys: Actions, Vitrines, Environments Discover more about Beuys’s life and art in this online guide to the major 2005 Beuys exhibition at Tate Modern.

For Joseph Beuys the day of his death This poem was written by artist Rebecca Horn in tribute to Joseph Beuys

Katie Guggenheim Recordings – Joseph Beuys Listen to Beuys’s powerful visionary ideas come to life in this audio restaging of interviews with the artist, which used published interviews as scripts.

In context

Claes Oldenburg Lipsticks in Piccadilly Circus, London 1966 Mixed media on board unconfirmed: 254 x 203 mm Presented by Hannah Wilke 1972© Claes Oldenburg

Performance Art 101: The Swinging Sixties, Pop, film, and Fluxus Find out what was happening in the 1960s in fashion, music and art and discover how it was the perfect environment for the founding and development of Fluxus.

Unlock Art: Frank Skinner on performance art Discover how the ideas and performances of Flux artists such as Yoko Ono, George Macunias, Joseph Beuys and Nam June Paik are an important part of the history and development of performance art more generally.

Other perspectives

Is the spirit of Fluxus still relevant in the twenty-first century? Watch these videos to find out how Fluxus-inspired ideas were re-born at Tate Modern…

Performance: The Flux Olympiad Fluxus founder, artist George Maciunas, first conceived of the Flux Olympiad in the 1960s, but it wasn’t until 2008, that his idea was acted upon and a Flux Olympiad was staged at Tate Modern. Watch this video to find out whether Fluxus ideas still have relevance from the perspective of the twenty-first century.

Performance: Make a Salad American artist Alison Knowles first made a salad in the name of art at London’s ICA Gallery in 1962. ‘Make a Salad’ is what the Flux artists termed an ‘event score’: a written instruction that can be acted out and changed according to the context in which it is performed. In Tate Modern’s giant Turbine Hall, Knowles has given the work a mammoth new dimension.

In detail

Joseph Beuys For Siberian Symphony 1962 Braunkreuz oil and watercolour on paper © DACS, 2009

Joseph Beuys at Tate (exerpts) 1972 For an intense fix of Joseph Beuys watch this video documentation of his visit to what was then the Tate Gallery (now Tate Britain) in 1972.

Audio Arts: Volume 13 No. 2 & 3 Listen to this interview with Flux artist Yoko Ono discussing her installation at the Venice Bienale in 1993.

More Fluxus: External resources you may find helpful

Fluxus Portal A useful resource for researchers which pulls together online texts and projects, and a list of publications for further reading.

Media Art Net Find out more about media art and the important role Fluxus artist Nam June Paik played in its development.

Related glossary terms

Neotack Dye Sublimation Ink Liter, Neotack

Details

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Additional Information

Cefaks, Cefaks

Ceftin is used for treating bacterial infections (sinus, skin, lung, urinary tract, ear, and throat). It may also be used to treat Lyme disease and gonorrhea. Ceftin is a cephalosporin antibiotic. It works by interfering with the formation of the bacteria's cell wall so that the wall ruptures, resulting in the death of the bacteria.

Use Ceftin as directed by your doctor.

Take Ceftin by mouth with or without food.

Swallow Ceftin whole. Do not break, crush, or chew before swallowing.

Ceftin works best if it is taken at the same time each day.

To clear up your infection completely, take Ceftin for the full course of treatment. Keep taking it even if you feel better in a few days.

If you miss a dose of Ceftin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose, and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Ceftin.

Store Ceftin at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Ceftin out of the reach of children and away from pets.

Active Ingredient: Cefuroxime axetil.

Do NOT use Ceftin if:

you are allergic to any ingredient in Ceftin or to any other cephalosporin antibiotic (eg, cephalexin, cefprozil).

Contact your doctor or health care provider right away if any of these apply to you.

Tell your health care provider if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have diarrhea, a stomach or intestinal infection, or a blood clotting problem

if you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to a penicillin antibiotic (eg, amoxicillin) or other beta-lactam antibiotic (eg, imipenem).

Some medicines may interact with Ceftin. Tell your health care provider if you are taking any other medicines, especially any of the following:

Aminoglycosides (eg, gentamicin), cyclosporine, diuretics (eg, furosemide, hydrochlorothiazide), or other medicines affecting the kidney because side effects, such as kidney toxicity, may occur

Hormonal contraceptives (eg, birth control pills) because their effectiveness may be decreased by Ceftin.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Ceftin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur during treatment or within several months after treatment with Ceftin. Do not treat diarrhea without first checking with your doctor.

The tablet and oral suspension forms of Ceftin are not equivalent. Do not substitute one for the other.

Ceftin only works against bacteria; it does not treat viral infections (eg, the common cold).

Be sure to use Ceftin for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.

Long-term or repeated use of Ceftin may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.

Diabetes patients - Ceftin may cause the results of some tests for urine glucose to be wrong. Ask your doctor before you change your diet or the dose of your diabetes medicine.

Hormonal birth control (eg, birth control pills) may not work as well while you are using Ceftin. To prevent pregnancy, use an extra form of birth control (eg, condoms).

Lab tests, including liver function, kidney function, and complete blood cell count, may be performed while you use Ceftin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Ceftin should not be used in children younger 3 months; safety and effectiveness in these children have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Ceftin while you are pregnant. Ceftin is found in breast milk. Do not breastfeed while taking Ceftin.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Diarrhea/loose stools; nausea; vomiting. Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools; change in the amount of urine; dark urine; easy bruising or bleeding; fatigue; fever; seizures; severe diarrhea; stomach cramps/pain; vaginal irritation or discharge; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Ceftin is used for treating bacterial infections (sinus, skin, lung, urinary tract, ear, and throat). It may also be used to treat Lyme disease and gonorrhea. Ceftin is a cephalosporin antibiotic. It works by interfering with the formation of the bacteria's cell wall so that the wall ruptures, resulting in the death of the bacteria.

Use Ceftin as directed by your doctor.

Take Ceftin by mouth with or without food.

Swallow Ceftin whole. Do not break, crush, or chew before swallowing.

Ceftin works best if it is taken at the same time each day.

To clear up your infection completely, take Ceftin for the full course of treatment. Keep taking it even if you feel better in a few days.

If you miss a dose of Ceftin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose, and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Ceftin.

Store Ceftin at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Ceftin out of the reach of children and away from pets.

Active Ingredient: Cefuroxime axetil.

Do NOT use Ceftin if:

you are allergic to any ingredient in Ceftin or to any other cephalosporin antibiotic (eg, cephalexin, cefprozil).

Contact your doctor or health care provider right away if any of these apply to you.

Tell your health care provider if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have diarrhea, a stomach or intestinal infection, or a blood clotting problem

if you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to a penicillin antibiotic (eg, amoxicillin) or other beta-lactam antibiotic (eg, imipenem).

Some medicines may interact with Ceftin. Tell your health care provider if you are taking any other medicines, especially any of the following:

Aminoglycosides (eg, gentamicin), cyclosporine, diuretics (eg, furosemide, hydrochlorothiazide), or other medicines affecting the kidney because side effects, such as kidney toxicity, may occur

Hormonal contraceptives (eg, birth control pills) because their effectiveness may be decreased by Ceftin.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Ceftin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur during treatment or within several months after treatment with Ceftin. Do not treat diarrhea without first checking with your doctor.

The tablet and oral suspension forms of Ceftin are not equivalent. Do not substitute one for the other.

Ceftin only works against bacteria; it does not treat viral infections (eg, the common cold).

Be sure to use Ceftin for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.

Long-term or repeated use of Ceftin may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.

Diabetes patients - Ceftin may cause the results of some tests for urine glucose to be wrong. Ask your doctor before you change your diet or the dose of your diabetes medicine.

Hormonal birth control (eg, birth control pills) may not work as well while you are using Ceftin. To prevent pregnancy, use an extra form of birth control (eg, condoms).

Lab tests, including liver function, kidney function, and complete blood cell count, may be performed while you use Ceftin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Ceftin should not be used in children younger 3 months; safety and effectiveness in these children have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Ceftin while you are pregnant. Ceftin is found in breast milk. Do not breastfeed while taking Ceftin.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Diarrhea/loose stools; nausea; vomiting. Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools; change in the amount of urine; dark urine; easy bruising or bleeding; fatigue; fever; seizures; severe diarrhea; stomach cramps/pain; vaginal irritation or discharge; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Kendral Adkisson, Gastroenterology Associates - Gastroenterology Doctor In Pensacola, Fl, Kendral

Dr. Kendral W. Adkisson, MD

Dr. Adkisson's Overview

Dr. Adkisson graduated from the University of Alabama School of Medicine in 1995. He works in Pensacola, FL and 1 other location and specializes in Gastroenterology. Dr. Adkisson is affiliated with Baptist Hospital, Sacred Heart Hospital and South Baldwin Regional Medical Center.

Dr. Adkisson's Experience

Years in Practice: 21

Conditions Treated by Dr. Adkisson

Procedures Performed by Dr. Adkisson

Dr. Adkisson's Specialties

Dr. Adkisson's Education & Training

Medical School: University of Alabama School of Medicine; Graduated 1995

Dr. Adkisson's Rating

Overall Rating

Physician

Dr. Adkisson's Accepted Insurance

Please verify insurance information directly with your doctor's office as it may change frequently.

Aetna Choice POS II

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BCBS AL PPO

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Dr. Adkisson's Office Information & Appointments

Office Locations

*This physician has multiple office locations. See Office Information for details.

Other Physicians in Dr. Adkisson's Practice

Tamoxifen - Woman S Health, Norflohexal

Tamoxifen is used for treating breast cancer that has spread to other sites in the body. It is also used along with other medicines to treat other types of breast cancer. It is used in women who are at high risk of breast cancer and in women with DCIS (after surgery and radiation) to decrease the risk of developing breast cancer. It may also be used for other conditions as determined by your doctor.

Use Tamoxifen as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Tamoxifen comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Tamoxifen refilled.

Tamoxifen may be taken by mouth with or without food.

Take Tamoxifen with water or another nonalcoholic liquid.

Swallow this medication whole. Do not break, crush, or chew before swallowing.

Continue taking Tamoxifen even if you feel well. Do not miss any doses. Take Tamoxifen at the same time each day.

Drug Class and Mechanism

Tamoxifen is an antiestrogen. It works by blocking the effect of estrogen on certain tumors. This may prevent the growth of tumors that are activated by estrogen.

If you miss a dose of Tamoxifen, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Store Tamoxifen between 68 and 77 degrees F (20 and 25 degrees C) in a tightly closed, light-resistant container. Store away from moisture, heat, and light. Do not store in the bathroom. Do not take tablets after the expiration date printed on the label. Keep Tamoxifen out of the reach of children and away from pets.

Do NOT use Tamoxifen if: you are allergic to any ingredient in Tamoxifen you are using Tamoxifen to reduce your risk of breast cancer and you have a history of blood clots in the lung or leg you are using Tamoxifen to reduce your risk of breast cancer and you also take certain anticoagulants (eg, warfarin) you are taking anastrozole Some medical conditions may interact with Tamoxifen. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you: if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have a history of blood clots in the legs or lungs if you have high levels of calcium in your blood, a weakened immune system, or low levels of white blood cells or platelets in your blood if you have high cholesterol or lipid levels if you have cataracts or other vision problems if you are using cytotoxic cancer medicines if you are confined to a bed or chair

Possible Side Effects

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

bone pain; constipation; coughing; hot flashes; muscle pain; nausea; tiredness; vaginal discharge; weight loss.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unexplained hoarseness); abnormal menstrual periods; abnormal vaginal bleeding or bloody discharge; chest pain; coughing up blood; dark urine; decreased sexual desire or ability; depression; fever, chills, or persistent sore throat; groin or pelvic pain or pressure; loss of appetite; loss of balance or coordination; missed menstrual period; new or increased breast tumor or pain; new or unusual lumps; one-sided weakness; pain or swelling in one or both legs; red, swollen, blistered, or peeling skin; severe or persistent tiredness or weakness; shortness of breath; skin changes; stomach pain; sudden severe headache; swelling of the arms or the legs; unusual bleeding or bruising; vision or speech problems; yellowing of the eyes or skin.

If you have any questions about Tamoxifen. please talk with your doctor, pharmacist, or other health care provider. Tamoxifen is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor.

Drugbank Desogestrel, Desogestrelum

For the prevention of pregnancy in women who elect to use this product as a method of contraception.

Desogestrel is used as a female contraceptive. Desogestrel is a progestin or a synthetic form of the naturally occurring female sex hormone, progesterone. In a woman's normal menstrual cycle, an egg matures and is released from the ovaries (ovulation). The ovary then produces progesterone, preventing the release of further eggs and priming the lining of the womb for a possible pregnancy. If pregnancy occurs, progesterone levels in the body remain high, maintaining the womb lining. If pregnancy does not occur, progesterone levels in the body fall, resulting in a menstrual period. Desogestrel tricks the body processes into thinking that ovulation has already occurred, by maintaining high levels of the synthetic progesterone. This prevents the release of eggs from the ovaries.

Mechanism of action

Binds to the progesterone and estrogen receptors. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins like desogestrel will slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH (luteinizing hormone) surge.

Following oral administration, the relative bioavailability of desogestrel, as measured by serum levels of etonogestrel, is approximately 84%. The absolute oral bioavailability is about 76%.

Volume of distribution

Desogestrel is rapidly and completely metabolized by hydroxylation in the intestinal mucosa and on first pass through the liver. It is primarily metabolized to 3α-hydroxydesogestrel with small amounts of 3β-hydroxydesogestrel being formed. Both of these metabolites are then rapidly oxidized to its active metabolite, etonogestrel (3-ketodesogestrel). Other metabolites (e. g. 2-hydroxydesogestrel) with no pharmacologic action have also been identified. Desogestrel and some of its metabolites (e. g. 3β-hydroxydesogestrel, 15β-hydroxydesogestrel) may also undergo glucuronide and sulfate conjugation. Early in vitro studies demonstrated that CYP2C9 and possibly CYP2C19 were involved in the conversion of desogestrel to 3α-hydroxydesogestrel and 3β-hydroxydesogestrel (PMID 9864282); however, later clinical studies conducted in humans refuted this result (PMID 15963096). The latter study indicates that CYP3A4 plays an important role in metabolizing etonogestrel. Thus, strong CYP3A4 inhibitors or inducers could result in increased side effects or therapeutic failure, respectively.

Targets

Kind Protein Organism Human Pharmacological action yes Actions agonist General Function: Zinc ion binding Specific Function: The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation. Isoform A: inactive in stimulating c-Src/MAPK signaling on hormone stimulation. Isoform 4: Increases mitochondrial. Gene Name: PGR Uniprot ID: P06401 Molecular Weight: 98979.96 Da

References

Bergink EW, van Meel F, Turpijn EW, van der Vies J: Binding of progestagens to receptor proteins in MCF-7 cells. J Steroid Biochem. 1983 Nov;19(5):1563-70. [PubMed:6645495 ]

Fuhrmann U, Slater EP, Fritzemeier KH: Characterization of the novel progestin gestodene by receptor binding studies and transactivation assays. Contraception. 1995 Jan;51(1):45-52. [PubMed:7750284 ]

Kloosterboer HJ, Vonk-Noordegraaf CA, Turpijn EW: Selectivity in progesterone and androgen receptor binding of progestagens used in oral contraceptives. Contraception. 1988 Sep;38(3):325-32. [PubMed:3139361 ]

Macpherson AM, Archer DF, Leslie S, Charnock-Jones DS, Makkink WK, Smith SK: The effect of etonogestrel on VEGF, oestrogen and progesterone receptor immunoreactivity and endothelial cell number in human endometrium. Hum Reprod. 1999 Dec;14(12):3080-7. [PubMed:10601100 ]

Charnock-Jones DS, Macpherson AM, Archer DF, Leslie S, Makkink WK, Sharkey AM, Smith SK: The effect of progestins on vascular endothelial growth factor, oestrogen receptor and progesterone receptor immunoreactivity and endothelial cell density in human endometrium. Hum Reprod. 2000 Aug;15 Suppl 3:85-95. [PubMed:11041225 ]

Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]

Kind Protein Organism Human Pharmacological action yes Actions agonist General Function: Zinc ion binding Specific Function: Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription fact. Gene Name: ESR1 Uniprot ID: P03372 Molecular Weight: 66215.45 Da

References

Fuhrmann U, Slater EP, Fritzemeier KH: Characterization of the novel progestin gestodene by receptor binding studies and transactivation assays. Contraception. 1995 Jan;51(1):45-52. [PubMed:7750284 ]

Rabe T, Bohlmann MK, Rehberger-Schneider S, Prifti S: Induction of estrogen receptor-alpha and - beta activities by synthetic progestins. Gynecol Endocrinol. 2000 Apr;14(2):118-26. [PubMed:10836199 ]

Juchem M, Pollow K: Binding of oral contraceptive progestogens to serum proteins and cytoplasmic receptor. Am J Obstet Gynecol. 1990 Dec;163(6 Pt 2):2171-83. [PubMed:2175153 ]

This project is supported by the Canadian Institutes of Health Research (award #111062), Alberta Innovates - Health Solutions. and by The Metabolomics Innovation Centre (TMIC). a nationally-funded research and core facility that supports a wide range of cutting-edge metabolomic studies. TMIC is funded by Genome Alberta. Genome British Columbia. and Genome Canada. a not-for-profit organization that is leading Canada's national genomics strategy with $900 million in funding from the federal government. Maintenance, support, and commercial licensing is provided by OMx Personal Health Analytics, Inc.

Prandimet (Repaglinide And Metformin Hcl Tablets) Side Effects, Interactions, Warning, Dosage & Uses

Lactic acidosis is a rare but serious complication that can occur due to metformin accumulation. The risk increases with conditions such as sepsis, dehydration, excess alcohol intake, hepatic impairment, renal impairment, and acute congestive heart failure.

The onset of lactic acidosis often is subtle, and accompanied only by nonspecific symptoms such as malaise, myalgias, respiratory distress, increasing somnolence, and nonspecific abdominal distress.

Laboratory abnormalities include low pH, increased anion gap and elevated blood lactate.

If acidosis is suspected, PrandiMet should be discontinued and the patient hospitalized immediately [see WARNINGS AND PRECAUTIONS ].

DRUG DESCRIPTION

PrandiMet (repaglinide and metformin HCl) tablets contain two oral antihyperglycemic drugs used in the management of type 2 diabetes: repaglinide and metformin HCl. The concomitant use of repaglinide and metformin has been previously approved based on clinical trials in patients with type 2 diabetes inadequately controlled on exercise, diet, and metformin HCl alone.

Repaglinide, S(+)2-ethoxy-4(2((3-methyl-1-(2-(1-piperidinyl) phenyl)-butyl) amino)-2-oxoethyl) benzoic acid, is chemically unrelated to the oral sulfonylurea insulin secretagogues. Repaglinide is a white to off-white powder with molecular formula C 27 H 36 N 2 O4 and a molecular weight of 452.6 with the structural formula as shown below. Repaglinide is freely soluble in methanol and ethanol. The pKa of repaglinide in acid is 3.9, and the pKa in amine is 6.0.

Structural formula of Repaglinide

Metformin HCl (N, N-dimethylimidodicarbonimidic diamide hydrochloride) is not chemically or pharmacologically related to any other classes of oral antihyperglycemic agents. Metformin HCl is a white to off-white crystalline compound with a molecular formula of C 4 H 11 N 5 •HCl and a molecular weight of 165.63. Metformin HCl is freely soluble in water and is practically insoluble in acetone, ether, and chloroform. The pKa of metformin HCl is 12.4. The pH of a 1% aqueous solution of metformin HCl is 6.68. The structural formula of metformin HCl is:

PrandiMet is available as a tablet for oral administration containing 1 mg repaglinide with 500 mg metformin HCl (1 mg/500 mg) or 2 mg repaglinide with 500 mg metformin HCl (2 mg/500 mg) formulated with the following inactive ingredients: poloxamer 188, microcrystalline cellulose, polacrillin potassium, magnesium stearate, hypromellose 3cp or 6cp, povidone, meglumine, sorbitol, talc, titanium dioxide, red or yellow iron oxide, and polyethylene glycol. Propylene glycol is present in the 2 mg/500 mg PrandiMet tablets.

What are the possible side effects of metformin and repaglinide (PrandiMet)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Hypoglycemia, or low blood sugar, is the most common side effect of metformin and repaglinide. Symptoms include headache, hunger, weakness, sweating, tremors, irritability, trouble concentrating, rapid breathing, fast heartbeat, fainting, or seizure (severe hypoglycemia can be fatal). Carry hard candy or glucose tablets with you in case you have low blood sugar.

This medication may cause.

What are the precautions when taking repaglinide and metformin hcl tablets (Prandimet)?

See also Warning section.

Before taking this medication, tell your doctor or pharmacist if you are allergic to repaglinide or metformin; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: kidney disease.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: severe breathing problems (such as obstructive lung disease, severe asthma), blood problems (such as anemia, vitamin B12 deficiency), heart problems (such as heart failure, recent heart attack).

Last reviewed on RxList: 5/7/2012 This monograph has been modified to include the generic and brand name in many instances.

Alivax (Antiepilpїѕptico) - Laboratorio Chile Lab, Alivax

ALIVAX - Laboratorio Chile Lab.

ComposiciпїЅn.

Indicaciones.

Tratamiento del dolor neuropпїЅtico central o perifпїЅrico. Esto incluye el dolor asociado a neuropatпїЅa diabпїЅtica perifпїЅrica y la neuralgia post-herpпїЅtica. En epilepsia, como tratamiento asociado para el control de las convulsiones parciales con o sin generalizaciпїЅn secundaria. Tratamiento del desorden de ansiedad generalizado (TAG).

DosificaciпїЅn.

El tratamiento con AlivaxпїЅse puede comenzar con una dosis de 75 mg dos veces al dпїЅa (150 mg al dпїЅa). En funciпїЅn de la respuesta y tolerabilidad individual de cada paciente, la dosis se puede incrementar hasta 150 mg dos veces al dпїЅa (300 mg al dпїЅa), despuпїЅs de un perпїЅodo de 3 a 7 dпїЅas; en raras ocasiones, ha sido пїЅtil una dosis mпїЅxima de 600 mg al dпїЅa despuпїЅs de un intervalo de 7 dпїЅas, pero no se recomienda por sus efectos adversos. Epilepsia: El tratamiento con AlivaxпїЅse puede iniciar con una dosis de 75 mg dos veces al dпїЅa (150 mg al dпїЅa). En funciпїЅn de la respuesta y tolerabilidad individual de cada paciente, la dosis se puede incrementar a 150 mg dos veces al dпїЅa (300 mg al dпїЅa) despuпїЅs de una semana. La dosis mпїЅxima que se puede alcanzar, despuпїЅs de una semana adicional, es de 600 mg al dпїЅa. Trastorno de ansiedad generalizada: El rango de dosis estudiado es de 150 a 600 mg al dпїЅa, dividiendo su administraciпїЅn en dos o tres tomas. Se debe reevaluar de forma periпїЅdica la necesidad del tratamiento. El tratamiento con pregabalina se puede iniciar con una dosis de 150 mg al dпїЅa. En funciпїЅn de la respuesta y tolerabilidad individual de cada paciente, la dosis se puede incrementar a 300 mg al dпїЅa despuпїЅs de una semana. Tras una semana adicional, la dosis se puede incrementar a 450 mg al dпїЅa. La dosis mпїЅxima que se puede alcanzar, despuпїЅs de una semana adicional, es de 600 mg al dпїЅa. En todos los casos es recomendable suspender el tratamiento reduciendo gradualmente la dosis, en el curso de al menos una semana.

Contraindicaciones.

Hipersensibilidad al principio activo o a alguno de los componentes. Madres en perпїЅodo de amamantamiento. NiпїЅos y adolescentes menores de 12 aпїЅos.

Reacciones adversas.

Las de mayor frecuencia han sido mareos y somnolencia. Generalmente, los efectos adversos han sido de intensidad leve a moderada. Las reacciones adversas mпїЅs importantes mencionadas han sido: Trastornos del sistema inmunolпїЅgico: Hipersensibilidad, angioedema, reacciпїЅn alпїЅrgica. Trastornos del metabolismo y de la nutriciпїЅn: Aumento del apetito o anorexia. Trastornos psiquiпїЅtricos: Estado de пїЅnimo eufпїЅrico, confusiпїЅn, irritabilidad, cambios en la libido. Alucinaciones, crisis de angustia, inquietud, agitaciпїЅn, estado de пїЅnimo depresivo, cambios del estado de пїЅnimo, despersonalizaciпїЅn, insomnio exacerbado, dificultad de expresiпїЅn, sueпїЅos anormales, anorgasmia, apatпїЅa. Trastornos del sistema nervioso: Mareos, somnolencia, ataxia, coordinaciпїЅn anormal, temblor, disartria, alteraciпїЅn de la memoria, alteraciпїЅn de la atenciпїЅn, parestesia. Trastornos oculares: VisiпїЅn borrosa, diplopпїЅa. AlteraciпїЅn de la visiпїЅn, hinchazпїЅn ocular, defecto del campo visual, agudeza visual disminuida. Trastornos del oпїЅdo y del laberinto: VпїЅrtigo. Trastornos cardiacos: Taquicardia. Insuficiencia cardiaca congestiva. Trastornos vasculares: RubefacciпїЅn, sofocos. Trastornos respiratorios: Disnea, sequedad nasal. Trastornos gastrointestinales: VпїЅmitos, sequedad de boca, estreпїЅimiento, flatulencia, reflujo gastroesofпїЅgico. Trastornos de la piel: ErupciпїЅn papular, sudoraciпїЅn. Trastornos mпїЅsculo-esquelпїЅticos: Movimientos musculares, hinchazпїЅn articular, calambres musculares, mialgia, artralgia, dolor de espalda, dolor en las extremidades, rigidez muscular. Trastornos renales y urinarios: Incontinencia urinaria, disuria. Trastornos del aparato reproductor: DisfunciпїЅn erпїЅctil, eyaculaciпїЅn retardada, disfunciпїЅn sexual. Otros trastornos: Marcha anormal, sensaciпїЅn de embriaguez, fatiga, edema perifпїЅrico. CaпїЅdas, opresiпїЅn en el pecho, astenia, sed. Aumento de peso. ElevaciпїЅn de creatinfosfoquinasa, alanina aminotransferasa, aspartato aminotransferasa. Recuento disminuido de plaquetas y leucocitos. En algunos pacientes se han observado sпїЅntomas de adicciпїЅn tras la interrupciпїЅn del tratamiento. Se debe informar al paciente sobre esto al inicio del tratamiento.

Interacciones.

Dado a que la pregabalina se excreta principalmente inalterada en orina, experimenta un metabolismo insignificante en humanos (

Nibel, Nibel

Announcements of the 2016 Nobel Prizes

The date and time for the announcements of the Nobel Prizes are now set.

PHYSIOLOGY OR MEDICINE - Monday 3 October, 11:30 a. m. at the earliest PHYSICS - Tuesday 4 October, 11:45 a. m. at the earliest CHEMISTRY - Wednesday 5 October, 11:45 a. m. at the earliest PEACE - Friday 7 October, 11:00 a. m. ECONOMIC SCIENCES - Monday 10 October, 11:45 a. m. at the earliest LITERATURE - The date will be set later. Times listed are local time in Sweden (CET). More details and information for the press

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Youngest Nobel Laureate ever is 17-year old Peace Prize Laureate Malala Yousafzai. 50 out of all Laureates were younger than 40 years old at the year of the award.

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Alfred Nobel. © Nobel Media AB. Photo: A. Mahmoud

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Mt. Nibel

Story Edit

Many years ago, Mt. Nibel was one of the many earliest locations which Shinra decided to open a Mako reactor at. While the nearby town of Nibelheim prospered due to the power it supplied, its forests and wildlife withered away due to its effects, and eventually became a barren coarse wasteland notorious for its dangerous monsters, from which many of the locals speak tales of people who ventured into its heights only to never return alive from again.

In 1995, Tifa Lockhart tried to climb Mt. Nibel to be reunited with her recently deceased mother, whom she believed she could meet if she crossed the mountain. A young Cloud Strife followed, but when Tifa was injured and fell into a coma, the local townsfolk blamed him and Tifa's father forbade Cloud from approaching Tifa.

Five years prior to the events of Final Fantasy VII . Sephiroth. Zack Fair. and several Shinra troops — including Cloud Strife — were sent to Nibelheim to investigate the reactor. With Tifa as their guide, the party was forced to advance through the caverns after a rope bridge snapped. They came across a Mako fountain, and while Tifa marveled at it Sephiroth explained the nature of magic and Materia.

Mt. Nibel is later revisited during Final Fantasy VII when the party crosses the mountain to reach Rocket Town.

Locations Edit

This article or section is a stub about a location in Final Fantasy VII. You can help the Final Fantasy Wiki by expanding it.

Path Edit

Bridge Edit

Cave Infrastructure Edit

Mountainside Edit

North Mako Cave Edit

Mako Fountain Edit

South Mako Cave Edit

Items found Edit

Crisis Core - Final Fantasy VII - Edit

Final Fantasy VII Edit

Enemies Edit

Approach Edit

Wooden Bridge Edit

Sonic Speed x3

Sonic Speed x2 (doesn't appear during the flashback)

Zuu (doesn't appear during the flashback)

Sonic Speed x2 (Ambush) (doesn't appear during the flashback)

Western Base Edit

Cave - Western Base Edit

Cave - Past Mako Fountain Edit

In Front of the Reactor Edit

Pipe Room* Edit

Eleanor - Name Meaning, What Does Eleanor Mean, Eleonor

♀ Eleanor

What does Eleanor mean?

E leanor [ele anor] as a girls' name is pronounced EL-a-nor . It is of Old French and Old German origin, and the meaning of Eleanor is "other, foreign". From an Old French respelling of the Proven?al name Alienor . from German ali . though sometimes it is taken as a variant of Helen . May also derive from Greek eleos meaning "compassion". Queen Eleanor of Aquitaine (12th century) was heiress to a large part of France. wife of two kings and mother of two more (Richard the Lionhearted and John). Her powerful personality, intelligence, and energy made her unique then. Literary: Jane Austen's Elinor Dashwood in "Sense and Sensibility". First Lady Eleanor Roosevelt; Italian actress Eleonora Duse; actress Elinor Donahue; women's rights activist Eleanor Smeal.

Variations

Eleanor has 3 more alternative forms via Helen: Elana . Ileana and Lienor .

Creative forms: (female) Eleanel, Eleanie. (male) Eleanan, Eleanen.

Middle name pairings: Eleanor Tyler (E. T.).

How popular is Eleanor?

Eleanor is a very popular first name for women (#148 out of 4276, Top 3%) but a unique surname for all people. (2000 U. S. Demographics)

Eleanor reached its peak rank of #29 in the U. S. during the years 1920-1929, and is currently at #60. (2015 U. S. SSA Records)

Micardis Side Effects In Detail, Cholstat

Micardis Side Effects

For the Consumer

Applies to telmisartan: oral tablet

In addition to its needed effects, some unwanted effects may be caused by telmisartan (the active ingredient contained in Micardis). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking telmisartan:

Rare

Changes in vision

dizziness, lightheadedness, or fainting

fast heartbeat

large hives

painful urination or changes in urinary frequency

swelling in the hands, lower legs, and feet

Incidence not known:

Blurred vision

chest pain or discomfort

confusion

dark-colored urine

decreased urine output

dilated neck veins

extreme fatigue

flushing

hives or welts

hoarseness

irregular breathing

irritation

itching

joint pain, stiffness, or swelling

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

muscle cramps or stiffness

numbness or tingling in the hands, feet, or lips

pain or discomfort in the arms, jaw, back, or neck

pounding in the ears

rash

redness of the skin

slow, fast, or irregular heartbeat

sweating

swelling of the eyelids, face, or lips

tightness in the chest

trouble breathing or swallowing

trouble with speaking or walking

trouble with thinking

unusual tiredness or weakness

unusually warm skin

weakness or heaviness of the legs

weakness, numbness, or tingling in the arms or legs

weight gain

Minor Side Effects

Some of the side effects that can occur with telmisartan may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common:

Abdominal or stomach pain

back pain

bloating or gas

changes in appetite

coughing

diarrhea

dry mouth

ear pain or hearing problems

fever

general tiredness or weakness

headache

heartburn

increased sweating

muscle pain or spasm

nausea

nervousness

runny or stuffy nose

sneezing

sore throat

Incidence not known:

Acid or sour stomach

belching

decreased interest in sexual intercourse

difficulty with moving

inability to have or keep an erection

indigestion

joint pain

lack or loss of strength

leg cramps

loss in sexual ability, desire, drive, or performance

muscle aching

stomach discomfort or upset

swelling

weakness

For Healthcare Professionals

Applies to telmisartan: oral tablet

General

The most common adverse events reported in hypertension trials were back pain, sinusitis, and diarrhea. The most common adverse events reported in cardiovascular risk reduction trials were intermittent claudication and skin ulcer. [Ref ]

Gastrointestinal

Common (1% to 10%): Diarrhea, dyspepsia, nausea, abdominal pain Uncommon (0.1% to 1%): Flatulence, vomiting, dry mouth, stomach discomfort, constipation, gastritis, hemorrhoids, gastroenteritis, enteritis, gastroesophageal reflux, toothache [Ref ]

Cardiovascular

Common (1% to 10%): Hypotension, palpitation, intermittent claudication, hypertension Uncommon (0.1% to 1%): Bradycardia, orthostatic hypotension, tachycardia, angina pectoris, flushing, dependent edema, abnormal ECG Postmarketing reports: Atrial fibrillation, congestive heart failure, myocardial infarction, blood pressure increased, hypertension aggravated [Ref ]

Respiratory

Common (1% to 10%): Coughing, upper respiratory tract infection, sinusitis, pharyngitis, bronchitis Uncommon (0.1% to 1%): Dyspnea, asthma, epistaxis, rhinitis Very rare (less than 0.01%): Interstitial lung disease [Ref ]

Musculoskeletal

Common (1% to 10%): Back pain, myalgia, arthralgia, muscle spasms Uncommon (0.1% to 1%): Gout, pain in extremity, arthritis Rare (less than 0.1%): Tendon pain, blood creatine phosphokinase increased Postmarketing reports: Rhabdomyolysis [Ref ]

Psychiatric

Common (1% to 10%): Insomnia, anxiety, depression Uncommon (0.1% to 1%): Nervousness [Ref ]

Nervous system

Common (1% to 10%): Headache, dizziness Uncommon (0.1% to 1%): Syncope, somnolence, migraine, paresthesia, hypoesthesia, cerebrovascular disorder Rare (less than 0.1%): Dysgeusia [Ref ]

Dermatologic

Common (1% to 10%): Rash, skin ulcer Uncommon (0.1% to 1%): Pruritus, hyperhidrosis, eczema, dermatitis, sweating increased Rare (less than 0.1%): Erythema, urticaria, drug eruption, toxic skin eruption [Ref ]

Genitourinary

Common (1% to 10%): Urinary tract infection Uncommon (0.1% to 1%): Micturition frequency, impotence, cystitis Postmarketing reports: Erectile dysfunction [Ref ]

Other

Common (1% to 10%): Pain, fatigue, influenza-like illness, chest pain, peripheral edema Uncommon (0.1% to 1%): Vertigo, asthenia, tinnitus, earache, malaise, fever, leg edema Postmarketing reports: Face edema [Ref ]

Immunologic

Uncommon (0.1% to 1%): Infection, fungal infection, abscess, otitis media, allergy, sepsis Rare (less than 0.1%): Anaphylactic reaction, angioedema, hypersensitivity Postmarketing reports: Angioneurotic edema [Ref ]

Metabolic

Uncommon (0.1% to 1%): Hyperkalemia, hypercholesterolemia, diabetes mellitus Rare (less than 0.1%): Hypoglycemia in diabetic patients [Ref ]

Hematologic

Uncommon (0.1% to 1%): Anemia, hemoglobin decreased Rare (less than 0.1%): Eosinophilia, thrombocytopenia [Ref ]

Renal

Uncommon (0.1% to 1%): Renal impairment including acute renal failure, blood creatinine increased Rare (less than 0.1%): Blood uric acid increased Frequency not reported: Acute renal failure [Ref ]

Ocular

Uncommon (0.1% to 1%): Conjunctivitis, visual disturbance [Ref ]

Hepatic

Rare (less than 0.1%): Hepatic function abnormal/liver disorder, hepatic enzyme increased [Ref ]

References

1. "Product Information. Micardis (telmisartan)." Boehringer-Ingelheim, Ridgefield, CT.

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Not all side effects for Micardis may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here .

Olanzapine Oral Uses, Side Effects, Interactions, Pictures, Warnings - Dosing, Olanzepine

olanzapine

GENERIC NAME(S): OLANZAPINE

Warnings

There may be a slightly increased risk of serious, possibly fatal side effects (such as stroke. heart failure. fast/irregular heartbeat. pneumonia ) when this medication is used by older adults with dementia. This medication is not approved for the treatment of dementia-related behavior problems. Discuss the risks and benefits of this medication, as well as other effective and possibly safer treatments for dementia-related behavior problems, with the doctor.

If you are using olanzapine in combination with other medication to treat depression. also carefully read the drug information for the other medication.

Uses

Olanzapine is used to treat certain mental/mood conditions (such as schizophrenia. bipolar disorder ). It may also be used in combination with other medication to treat depression. This medication can help to decrease hallucinations and help you to think more clearly and positively about yourself, feel less agitated, and take a more active part in everyday life.

Olanzapine belongs to a class of drugs called atypical antipsychotics. It works by helping to restore the balance of certain natural substances in the brain .

Talk to the doctor about the risks and benefits of treatment (especially when used by teenagers). See also Precautions section.

OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.

This medication may also be used to prevent nausea and vomiting caused by cancer drug treatment (chemotherapy ).

How to use olanzapine

Read the Medication Guide provided by your pharmacist before you start taking olanzapine and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth with or without food as directed by your doctor, usually once daily.

The dosage is based on your medical condition and response to treatment. To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's instructions carefully.

Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. It is important to continue taking this medication as prescribed even if you feel well. Do not stop taking this medication without consulting your doctor.

Tell your doctor if your condition persists or worsens.

Side Effects

Drowsiness, dizziness. lightheadedness, stomach upset, dry mouth. constipation. increased appetite, or weight gain may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: difficulty swallowing, shaking (tremor), signs of infection (such as fever, persistent sore throat. swollen lymph nodes ), slow heartbeat, fainting. mental/mood changes (such as confusion, restlessness), numbness/tingling of arms/legs, yellowing eyes /skin. severe stomach /abdominal pain. shortness of breath, trouble urinating.

This drug may rarely make your blood sugar level rise, which can cause or worsen diabetes. Tell your doctor right away if you develop symptoms of high blood sugar. such as increased thirst and urination. If you already have diabetes. be sure to check your blood sugars regularly. Your doctor may need to adjust your diabetes medication, exercise program. or diet.

This drug may also cause significant weight gain and a rise in your blood cholesterol (or triglyceride ) levels, especially in teenagers. These effects, along with diabetes, may increase your risk for developing heart disease. Discuss the risks and benefits of treatment with your doctor. (See also Notes section.)

Olanzapine may rarely cause a condition known as tardive dyskinesia. In some cases, this condition may be permanent. Tell your doctor right away if you develop any unusual/uncontrolled movements (especially of the face, lips, mouth. tongue. arms or legs).

This medication may increase a certain natural substance (prolactin ) made by your body. For females, this increase in prolactin may result in unwanted breast milk, missed/stopped periods, or difficulty becoming pregnant. For males, it may result in decreased sexual ability, inability to produce sperm. or enlarged breasts. If you develop any of these symptoms, tell your doctor right away.

Get medical help right away if you have any very serious side effects, including: seizures, chest pain.

This medication may rarely cause a very serious condition called neuroleptic malignant syndrome (NMS). Get medical help right away if you have any of the following symptoms: fever, muscle stiffness/pain/tenderness/weakness, severe tiredness, severe confusion, sweating, fast/irregular heartbeat, dark urine, signs of kidney problems (such as change in the amount of urine).

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking olanzapine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver problems, seizures, difficulty swallowing, low white blood cell count, dementia, difficulty urinating (for example, due to enlarged prostate), glaucoma (narrow angle), stomach/intestinal disease (such as blockage, paralytic ileus), smoking, personal or family history of diabetes, heart disease, high cholesterol/triglyceride levels.

This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Avoid alcoholic beverages.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

This medication may make you sweat less, making you more likely to get heat stroke. Avoid doing things that may cause you to overheat, such as hard work or exercise in hot weather, or using hot tubs. When the weather is hot, drink a lot of fluids and dress lightly. If you overheat, quickly look for a place to cool down and rest. Get medical help right away if you have a fever that does not go away, mental/mood changes, headache, or dizziness.

Teenagers may be more sensitive to the side effects of this drug, especially weight gain, and also increased amounts of cholesterol, triglycerides, and prolactin. See also Side Effects section for more details.

Older adults may be more sensitive to the side effects of this drug, especially drowsiness, constipation, trouble urinating, confusion, or dizziness upon standing. Drowsiness, confusion, and dizziness can increase the risk of falling.

During pregnancy, this medication should be used only when clearly needed. Babies born to mothers who have used this drug during the last 3 months of pregnancy may rarely develop symptoms including muscle stiffness or shakiness, drowsiness, feeding/breathing difficulties, or constant crying. If you notice any of these symptoms in your newborn especially during their first month, tell the doctor right away.

Since untreated mental/mood problems (such as schizophrenia, bipolar disorder, depression) can be a serious condition, do not stop taking this medication unless directed by your doctor. If you are planning pregnancy, become pregnant, or think you may be pregnant, immediately discuss with your doctor the benefits and risks of using this medication during pregnancy.

This drug passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

A product that may interact with this drug is: metoclopramide.

Tell your doctor or pharmacist if you are taking other products that cause drowsiness including alcohol, antihistamines (such as cetirizine, diphenhydramine), drugs for sleep or anxiety (such as alprazolam, diazepam, zolpidem), muscle relaxants, and narcotic pain relievers (such as codeine).

Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.

Overdose

If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: severe drowsiness/dizziness, fast/irregular heartbeat, unusual/uncontrolled movements, seizures.

Notes

Do not share this medication with others.

Laboratory and/or medical tests (such as blood sugar, weight, blood pressure, blood cholesterol/triglyceride levels, liver function tests) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Information last revised May 2016. Copyright(c) 2016 First Databank, Inc.

Images

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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Traffic, Demographics And Competitors, Pronor

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Where can I find more info about pronor. com?

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Heart Disease And Antiplatelet Drugs, Antiplat

Heart Disease and Antiplatelet Drugs

Antiplatelet drugs are used to treat heart disease. They are a group of powerful medications that prevent the formation of blood clots. When you are wounded, platelets arrive on the scene and group together, forming a blood clot that stops the bleeding. When an injury involves a break in your skin. this is a good thing. But platelets can also aggregate when injury to a blood vessel occurs from within the inside, as may happen in an artery affected by atherosclerosis. In this situation, the platelets cause blood clots to develop in an already injured artery. Antiplatelet medications can prevent this process from happening.

Why Are Antiplatelets Used?

Antiplatelets may be prescribed for patients with a history of:

Antiplatelets are also used:

After angioplasty and stent placement.

After heart bypass or valve replacement surgery.

To prevent the formation of blood clots in people with atrial fibrillation .

How Are Antiplatelets Taken?

Antiplatelets are pills that are usually taken once or twice a day. They should not be taken on an empty stomach .

Before this medication is prescribed, tell your doctor if you are allergic to aspirin. ibuprofen. or naproxen .

People with bleeding problems, ulcers, or those who are planning to undergo surgery, including dental surgery, should talk to their doctor before taking these drugs, as they may cause excessive bleeding.

You should not stop taking your antiplatelet drug unless advised by your doctor.

These drugs may need to be taken for the rest of your life, depending on your condition. You may need to undergo regular blood tests to monitor your medication dosage. Keep all appointments with your doctor and the laboratory so that your response to the medication can be checked.

While taking these antiplatelets, ask your doctor what medicines you may take for pain relief or minor colds. Read the labels of other pain relievers and cold products to make sure they are aspirin-free. Medicines containing aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs ) may cause bleeding problems when taken along with antiplatelet drugs.

Before any surgery, dental procedure, or emergency treatment, tell the doctor or dentist that you are taking this medicine. You might need to stop taking it for five to seven days before dental work or surgery. However, do not stop taking this medicine without first consulting with your doctor.

Use caution during activities requiring alertness (such as driving a car) until you know how this drug affects you.

Continued

Are There Side Effects of Antiplatelets?

Antiplatelets may have side effects. Nausea. upset stomach. stomach pain. diarrhea. rash. and itching are the most common side effects. To reduce nausea and stomach upset, take these medications with meals. Contact your doctor if these side effects are severe or do not go away.

People taking antiplatelet medication are advised to contact their doctor immediately if they experience any of the following:

Any signs of unusual bleeding, such as blood in the urine or stool, nosebleeds. any unusual bruising, heavy bleeding from cuts, black tarry stools, coughing up of blood, unusually heavy menstrual bleeding or unexpected vaginal bleeding. vomit that looks like coffee grounds.

Dizziness

Severe headache

Difficulty swallowing

Shortness of breath

Difficulty breathing or wheezing

Tightness in chest, chest pain

Fever, chills, sore throat

Swelling of face or hands

Ringing in the ears

Severe stomach pain

Side effects of antiplatelets can be worse in people with asthma and allergies .

Can Pregnant Women Take Antiplatelets?

If you are pregnant or are trying to become pregnant, inform your doctor before taking antiplatelets.

Taking antiplatelets during the last two weeks of pregnancy may cause bleeding problems in the baby or mother both before and after delivery.

Can I Breastfeed My Baby While Taking Antiplatelets?

Antiplatelets can be passed to the infant through breast milk. However, their effect on nursing infants is unknown. You should discuss the benefits and risks with your doctor and your baby's doctor.

WebMD Medical Reference Reviewed by James Beckerman, MD, FACC on January 16, 2015

Sources

Aquarius Horoscope Aquarius Zodiac Sign Dates Compatibility, Traits And Characteristics, Aquarius

Aquarius Zodiac Sign Aquarius Horoscope

Aquarius Horoscope: Yesterday

Communicate freely but be careful not to judge others for who they are. Just because you have the "right way" of doing things, this doesn't necessarily mean somebody else doesn't have it too. Prejudice can go a long way, especially when it comes to family members and people you have an intimate relationship with.

As the Moon comes to a conjunction with Uranus, you will get sensitive and stressed, even more so than usual. Have enough time for rest and exercise to strengthen your physical body.

Aquarius Horoscope: Today

People who eat spicy food tend to live longer, according to a 2015 study. Still, you shouldn't overdo eating spicy food today, for even though it might give you the energy you need, it could also spark some sort of aggressive behavior that you don't know how to control.

This is a day that could feel tiring and as if it will never end, mostly because of the need you have to spend some time at home, relax and enjoy simple things in life.

Aquarius Horoscope: This Week

After a quarrel or maybe even a serious conflict that took place in this previous week, you will need some time to recover and understand which side you are really on. While you do this, remember that there are no actual "sides" and we are all separated only by the narrowness of our minds and hearts.

Do your best to heal yourself and mend some wounds that are hard to ever forget. If you've learned your lessons there is no reason to feel fear or surrender to weakness and give up on anything you want to fight for.

This week’s affirmation: "I am stable and connected to the ground."

Aquarius Horoscope: This Month

You will feel acceptance for other people rising day after day, and your social life finally resembling the one you’ve had before. The liberation and fulfillment of finished work on yourself and your inner shadows will bring a lot of satisfaction in weeks to come. Hopefully, you didn’t dismiss too many emotions and valuable people, excluding them from your life.

You still have a lot to learn. Think of this time as your opportunity to find direction and hope for everything the future might bring. Your mission is at the grasp of your hand and once you realize what it is, steps towards it will be a lot simpler. Clarity in your attempts and motivation will ultimately lead to easier circumstances and support from the Universe to follow your cause.

Aquarius Love and Sex

Intellectual stimulation is by far the greatest aphrodisiac for Aquarius. There's nothing that can attract an Aquarius more than an interesting conversation with a person. Openness, communication, imagination and willingness to risk are the qualities that fit well in the perspective of life of this zodiac sign. Their compatibility with other signs can be complex, Integrity and honesty are essential for anyone who wants a long-term relationship with this dynamic person. In love, they are loyal, committed and not at all possessive - they give independence to their partners and consider them as equals.

Aquarius Friends and Family

Although Aquarius-born are communicative, they need time to get close to people. Considering that they are highly sensitive people, closeness to them means vulnerability.

Their immediacy behavior combined with their strong views, makes them a challenge to meet. Aquarius will do anything for a loved one to the point of self-sacrifice if necessary.

Their friends should possess these three qualities: creativity, intellect and integrity. When it comes to family, their expectations are nothing less. Although they have a sense of duty to relatives, they will not maintain close ties if the same expectations as in friendship are not fulfilled.

Aquarius Career and Money

Aquarius-born bring enthusiasm to the job and have a remarkable ability of exploitation of their imagination for business purposes. Career which enables a development and demonstration of the concept will suit this zodiac sign. Their high intellect combined with their willingness to share their talents, inspires many who work in their environment. Aquarius is a visionary type who likes to engage in activities that aim to make humanity better.

When it comes to money, this zodiac sign has a talent to maintain a balance between spending and saving money. Most people born under the sign of Aquarius are well adapted to their feel for style and they are not afraid to show it. It is not uncommon to see an Aquarius boldly dressed in brightly colored suits.

Careers such as acting, writing, teaching, photography or piloting, are suitable for this sign. The best environment for them is one that gives them the freedom to solve the problem without strict guidelines. Aquarius is an unconventional type and if given the opportunity to express their talent, can achieve remarkable success.

How to Attract the Aquarius Man

You should learn about all the positive and negative Aquarius traits if you want to seduce man born under this zodiac sign. Aquarius men are unpredictable, intelligent, social, independent and excellent communicators. Some of the negative Aquarius characteristics include unreliability, stubbornness, indecision, and inflexibility.

If you want to seduce the man born under the Aquarius astrology sign, you will have to be cool about it. If you ever come on too strong emotionally for this man, he will never even think about taking you to bed.

The Aquarius man can often live inside his own mind, so he needs a companion to talk about the progressive thoughts he creates. So, if you want to seduce him, you should be friends first. Most of their romances tend to start out as friendships which gradually evolve into something more serious. This means that the Aquarius men will never enter into a romantic relationship with someone who isn't already a friend. Be patient and keep things on a platonic basis until you're ready to make your first big move. Respect his need for freedom, his individuality, and his desire to make a difference in the world.

How to Attract the Aquarius Woman

Aquarius personality is independent, mysterious, free-spirited and eccentric. Aquarius women have a unique sense of humour and a practical outlook in life. However, inconsistency is a constant problem for women born under the Aquarius zodiac sign.

The Aquarius woman longs for romance and good conversation, although she may seem like a cold and aloof person. She is an excellent sex partner, but only if she is convinced that you are interested in more than just a one night stand.

If you want to seduce a woman born under the Aquarius star sign, you will have to appeal to the multiple different sides of her personality. Aquarius women are drawn to people who stand out from the crowd, so if you want to attract her attention it's important to come across as a bit different from everyone else she knows.

The Aquarius woman is a highly imaginative sex partner, who wants to try out new things on a regular basis. However, make sure to let her know that she is more than just a sex partner to you.

The worst mistake you can make when trying to seduce the Aquarius woman is to be too demanding and pushy. Give her lots of freedom, because she is a very independent woman and won't tolerate any kind of control. In order to attract her attention, show her that you're the cool and calm type. The Aquarius woman feels uncomfortable with people who openly express their feelings, so avoid emotionally charged issues and appeal to her intellect instead.

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Important Notice: The Drugs. com international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

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Buy Robax Platinum Online From Canada Drugs - Online Canadian, Robax Platinum

Robax Platinum and/or Equivalents

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Canada Drugs is the leading international prescription service provider in patient safety. Under strict quality assurance measures, every step is taken to ensure the safety and accuracy of each prescription when you order Robax Platinum from our online pharmacy.

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Notice: The above information is an educational aid only. It is not intended as medical advice for individual conditions or treatments. Talk to your doctor, nurse or pharmacist before following any medical regimen to see if it is safe and effective for you.

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Buy Nittyfor - Permethrin - Online Without Prescriptions, Nittyfor

Acticin (Nittyfor)

Acticin Cream is used for treating scabies. Acticin Cream is a scabicide. It works by killing the scabies mite (Sarcoptes scabiei).

Use Acticin Cream as directed by your doctor.

Thoroughly massage into the skin from the head to the soles of the feet. It is not necessary to put the medicine on the scalp except children and older patients.

Remove the medicine by washing after 8 to 14 hours.

You may experience itching after treatment. This is not a sign of treatment failure. However if living mites are seen after 14 days, retreatment is necessary.

If you miss a dose of Acticin Cream, use it as soon as you remember. Continue to use it as directed by your doctor.

Ask your health care provider any question you may have about how to use Acticin Cream.

Store Acticin Cream at room temperature, between 59 and 77 degrees F (15 and 25 degrees C). Store away from heat, moisture, and light. Keep Acticin Cream out of the reach of children and away from pets.

Active Ingredient: Permethrin.

Do NOT use Acticin Cream if:

you are allergic to any ingredient in Acticin Cream.

Some medical conditions may interact with Acticin Cream. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances.

Some medicines may interact with Acticin Cream.

Important safety information:

Acticin Cream is for external use only. Do not use it near the eyes or allow it to come into contact with the inside of the nose, mouth, or genitals. Irritation may occur if Acticin Cream comes into contact with these areas. If Acticin Cream gets in your eyes, flush with water immediately.

Acticin Cream should not be used by children younger than 2 months ; safety and effectiveness in these age have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Acticin Cream while you are pregnant. It is not known if Acticin Cream is found in breast milk after topical use. Do not breast-feed while using Acticin Cream.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Itching; mild burning or stinging; redness; swelling.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Prometazina - Bula De Prometazina, Prometazina

Prometazina

Indicacao

Para que serve?

Cloridrato de prometazina e indicado para o tratamento de reacoes alergicas e anafilaticas, na prevencao de vomitos do pos-operatorio e enjoos de viagens, entre outras indicacoes.

Uso adulto - Uso oral

Farmacocinetica

Como funciona?

O cloridrato de prometazina e um medicamento que apresenta propriedades antialergicas, sedativas e antiemeticas.

Os efeitos clinicos do cloridrato de prometazina comprimido revestido sao notados dentro de 20 minutos apos a administracao e geralmente duram de 4 a 6 horas, embora possam persistir ate por 12 horas.

Posologia

Como usar?

Adultos: 2 a 6 comprimidos por dia.

Estas doses devem ser divididas em duas, tres ou quatro vezes, reservando-se a maior fracao para a noite.

Este medicamento nao pode ser partido ou mastigado.

Efeitos Colaterais

Quais os males que pode me causar?

Embora sejam infrequentes, alguns efeitos colaterais podem ocorrer durante o tratamento com cloridrato de prometazina comprimido revestido.

Sonolencia e o efeito colateral mais comum.

Outros efeitos, embora raros, podem ocorrer, como tontura, confusao mental, secura da boca, palpitacoes, queda de pressao, erupcoes na pele (como urticaria, eczema, e manchas avermelhadas no corpo), nauseas e vomitos.

Podem ocorrer alteracao na contagem de leucocitos e hemacias e sintomas neurologicos.

Contraindicacoes

Quando nao devo usar?

O cloridrato de prometazina comprimido revestido nao deve ser utilizado por pacientes com conhecida hipersensibilidade a prometazina ou outros derivados fenotiazinicos ou a qualquer componente da formula, assim como aos portadores ou com antecedentes de doencas sanguineas causadas por outros fenotiazinicos, em pacientes com risco de retencao urinaria ligado a disturbios uretro prostaticos, e em pacientes com glaucoma.

A prometazina nao deve ser utilizada em criancas menores de dois anos devido ao risco de depressao respiratoria fatal.

Este medicamento e contraindicado na faixa etaria de 0 a 2 anos.

Advertencias e Precaucoes

O que devo saber antes de usar?

Cloridrato de prometazina na gravidez e lactacao: informe seu medico a ocorrencia de gravidez na vigencia do tratamento com cloridrato de prometazina ou apos o seu termino.

Informar ao medico se estiver amamentando.

Este medicamento so deve ser utilizado durante a gravidez sob orientacao medica e, seu uso e desaconselhado durante a amamentacao.

Em caso de persistencia ou de agravamento dos sintomas alergicos (dispneia, edema, lesoes cutaneas, etc) ou de sinais associados de infeccao viral, deve-se reavaliar o paciente e as condutas adotadas.

Deve-se, se possivel, identificar a causa de insonia e de possiveis fatores subjacentes tratados.

A persistencia de insonia depois de 5 dias de tratamento pode indicar uma doenca subjacente, e o tratamento dever ser reavaliado.

O cloridrato de prometazina deve ser usado com precaucao em pacientes que estejam em tratamento com tranquilizantes ou barbituricos, pois podera ocorrer potencializacao da atividade sedativa.

A vigilancia clinica e, eventualmente, eletroencefalografica, deve ser reforcada em pacientes epilepticos devido a possibilidade de diminuicao do limiar epileptogenico dos fenotiazinicos.

Este medicamento deve ser utilizado com cautela nas seguintes situacoes:

Individuos (especialmente os idosos) com sensibilidade aumentada a sedacao, a hipotensao ortostatica, e as vertigens; em pacientes com constipacao cronica por causa do risco de ileo paralitico; em eventual hipertrofia prostatica. Nos individuos portadores de determinadas afeccoes cardiovasculares, por causa dos efeitos taquicardizantes e hipotensores das fenotiazinas. Em casos de insuficiencia hepatica e/ou renal grave por causa do risco de acumulo.

Como as demais drogas sedativas ou depressoras do SNC, o cloridrato de prometazina deve ser evitado em pacientes com historia de apneia noturna.

Bebidas alcoolicas e medicamentos contendo alcool devem ser evitados durante tratamento com cloridrato de prometazina. Durante o tratamento, o paciente nao deve dirigir veiculos ou operar maquinas, pois sua habilidade e atencao podem estar prejudicadas.

Considerando os efeitos fotossensibilizantes das fenotiazinas, a exposicao a luz solar ou a luz artificial e desaconselhada durante o tratamento.

O uso de prometazina deve ser evitado em criancas e adolescentes com sinais e sintomas sugestivos da Sindrome de Reye.

Recomenda-se cautela na administracao do cloridrato de prometazina comprimido revestido em individuos idosos, com sensibilidade aumentada a sedacao, a hipotensao ortostatica e as vertigens, em pacientes com constipacao cronica por causa do risco de ileo paralitico e em eventual hipertrofia prostatica.

Os pacientes idosos, em razao das funcoes hepatica e renal reduzidas, podem se mostrar mais suscetiveis a apresentar reacoes adversas, particularmente sintomas extrapiramidais, falta de coordenacao motora e tremores e, por isso, recomenda-se cautela na administracao do cloridrato de prometazina comprimido revestido.

A associacao com alcool aumenta os efeitos sedativos dos anti-histaminicos H1.

A alteracao da vigilancia pode tornar perigosa a conducao de veiculos e operacao de maquinas.

Por isso recomenda-se evitar a ingestao de bebidas alcoolicas e de medicamentos contendo alcool durante o tratamento.

A associacao com sultoprida apresenta um risco maior de alteracoes do ritmo cardiaco ventricular, por adicao dos efeitos eletrofisiologicos.

Associacoes a serem consideradas:

A acao sedativa da prometazina e aditiva aos efeitos de outros depressores do SNC, como derivados morfinicos (analgesicos narcoticos e antitussigenos), metadona, clonidina e compostos semelhantes, sedativos, hipnoticos, antidepressivos triciclicos e tranquilizantes. Portanto, estes agentes devem ser evitados ou, entao, administrados em doses reduzidas a pacientes em uso de prometazina.

A associacao com atropina e outras substancias atropinicas (antidepressivos imipraminicos, antiparkinsonianos, anticolinergicos, antiespasmodicos atropinicos, disopiramida, neurolepticos fenotiazinicos) pode resultar em efeitos aditivos dos efeitos indesejaveis atropinicos como a retencao urinaria, constipacao intestinal e secura na boca.

Evitar o uso com IMAO, pois estes prolongam e intensificam os efeitos anticolinergicos da prometazina.

Superdosagem

O que fazer se alguem usar uma quantidade maior do que a indicada?

O quadro clinico resultante da superdose com cloridrato de prometazina vai desde leve depressao do SNC e sistema cardiovascular, ate profunda hipotensao, depressao respiratoria e perda da consciencia.

Pode ocorrer agitacao, especialmente em pacientes geriatricos.

Convulsoes raramente ocorrem.

Sinais e sintomas do tipo atropinico, como boca seca, pupilas fixas e dilatadas, “flushing” e sintomas gastrointestinais tambem podem ocorrer.

O tratamento e essencialmente sintomatico e de suporte.

Lavagem gastrica deve ser feita o mais precocemente possivel.

Somente em casos extremos torna-se necessaria a monitorizacao dos sinais vitais.

A naloxona reverte alguns dos efeitos depressivos, mas nao todos. Hipotensao severa, em geral, responde a administracao de norepinefrina ou fenilefrina.

Epinefrina nao deve ser utilizada, ja que seu uso em pacientes com bloqueio adrenergico parcial pode baixar ainda mais a pressao arterial.

Experiencias limitadas com dialise indicam que ela nao e util nestes casos.

Composicao

Cada comprimido revestido de 25 mg contem:

cloridrato de prometazina. 25 mg

excipientes q. s.p. 1 comprimido revestido

Excipientes: lactose monoidratada, amido, metabissulfito de sodio, povidona, estearato de magnesio, copolimero de polivinil alcool-polietilenoglicol, dioxido de titanio, corante amarelo laca aluminio n? 5, macrogol 6.000.

Comprimido revestido de 25 mg: embalagem com 20, 80, 120, 240, 320 e 500 comprimidos revestidos.

Armazenamento

Onde como e por quanto tempo posso guardar?

Este medicamento deve ser armazenado em sua embalagem original, em temperatura ambiente (entre 15? e 30 ?C), em lugar seco, fresco e ao abrigo da luz (evite armazena-lo no banheiro).

Nestas condicoes o prazo de validade e de 24 meses a contar da data de fabricacao.

Antes de usar observe o aspecto do medicamento.

O cloridrato de prometazina e um comprimido revestido de coloracao amarela, circular e nao sulcado.

Laboratorio

- SAC: 0800 709 9333

Farmaceutico Responsavel: Dr. Luiz Donaduzzi CRF-PR 5842

Nebivolol (Professional Patient Advice), Nebilox

Nebivolol

Drug Interactions

Acetylcholinesterase Inhibitors: May enhance the bradycardic effect of Beta-Blockers. Monitor therapy

Alfuzosin: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy

Alpha-/Beta-Agonists (Direct-Acting): Beta-Blockers may enhance the vasopressor effect of Alpha-/Beta-Agonists (Direct-Acting). Epinephrine used as a local anesthetic for dental procedures will not likely cause clinically relevant problems. Some beta-adrenoceptor mediated effects of Alpha-/Beta-Agonists (Direct-Acting), including anti-anaphylactic effects of epinephrine, may be diminished by Beta-Blockers. Management: Cardioselective beta-blockers and lower doses of epinephrine may confer a more limited risk. Patients who may require acute subcutaneous epinephrine (e. g. bee sting kits) should probably avoid beta blockers. Exceptions: Dipivefrin. Consider therapy modification

Alpha1-Blockers: Beta-Blockers may enhance the orthostatic hypotensive effect of Alpha1-Blockers. The risk associated with ophthalmic products is probably less than systemic products. Monitor therapy

Alpha2-Agonists: May enhance the AV-blocking effect of Beta-Blockers. Sinus node dysfunction may also be enhanced. Beta-Blockers may enhance the rebound hypertensive effect of Alpha2-Agonists. This effect can occur when the Alpha2-Agonist is abruptly withdrawn. Management: Closely monitor heart rate during treatment with a beta blocker and clonidine. Withdraw beta blockers several days before clonidine withdrawal when possible, and monitor blood pressure closely. Recommendations for other alpha2-agonists are unavailable. Exceptions: Apraclonidine. Consider therapy modification

Amifostine: Blood Pressure Lowering Agents may enhance the hypotensive effect of Amifostine. Management: When amifostine is used at chemotherapy doses, blood pressure lowering medications should be withheld for 24 hours prior to amifostine administration. If blood pressure lowering therapy cannot be withheld, amifostine should not be administered. Consider therapy modification

Aminoquinolines (Antimalarial): May decrease the metabolism of Beta-Blockers. Monitor therapy

Amiodarone: May enhance the bradycardic effect of Beta-Blockers. Possibly to the point of cardiac arrest. Amiodarone may increase the serum concentration of Beta-Blockers. Monitor therapy

Amphetamines: May diminish the antihypertensive effect of Antihypertensive Agents. Monitor therapy

Anilidopiperidine Opioids: May enhance the bradycardic effect of Beta-Blockers. Anilidopiperidine Opioids may enhance the hypotensive effect of Beta-Blockers. Monitor therapy

Antipsychotic Agents (Phenothiazines): May enhance the hypotensive effect of Beta-Blockers. Beta-Blockers may decrease the metabolism of Antipsychotic Agents (Phenothiazines). Antipsychotic Agents (Phenothiazines) may decrease the metabolism of Beta-Blockers. Monitor therapy

Antipsychotic Agents (Second Generation [Atypical]): Blood Pressure Lowering Agents may enhance the hypotensive effect of Antipsychotic Agents (Second Generation [Atypical]). Monitor therapy

Barbiturates: May decrease the serum concentration of Beta-Blockers. Monitor therapy

Barbiturates: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy

Beta2-Agonists: Beta-Blockers (Beta1 Selective) may diminish the bronchodilatory effect of Beta2-Agonists. Of particular concern with nonselective beta-blockers or higher doses of the beta1 selective beta-blockers. Monitor therapy

Bradycardia-Causing Agents: May enhance the bradycardic effect of other Bradycardia-Causing Agents. Monitor therapy

Bretylium: May enhance the bradycardic effect of Bradycardia-Causing Agents. Bretylium may also enhance atrioventricular (AV) blockade in patients receiving AV blocking agents. Monitor therapy

Brimonidine (Topical): May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy

Bupivacaine: Beta-Blockers may increase the serum concentration of Bupivacaine. Monitor therapy

Calcium Channel Blockers (Nondihydropyridine): May enhance the hypotensive effect of Beta-Blockers. Bradycardia and signs of heart failure have also been reported. Calcium Channel Blockers (Nondihydropyridine) may increase the serum concentration of Beta-Blockers. Exceptions: Bepridil. Monitor therapy

Cardiac Glycosides: Beta-Blockers may enhance the bradycardic effect of Cardiac Glycosides. Monitor therapy

Ceritinib: Bradycardia-Causing Agents may enhance the bradycardic effect of Ceritinib. Management: If this combination cannot be avoided, monitor patients for evidence of symptomatic bradycardia, and closely monitor blood pressure and heart rate during therapy. Avoid combination

Cholinergic Agonists: Beta-Blockers may enhance the adverse/toxic effect of Cholinergic Agonists. Of particular concern are the potential for cardiac conduction abnormalities and bronchoconstriction. Management: Administer these agents in combination with caution, and monitor for conduction disturbances. Avoid methacholine with any beta blocker due to the potential for additive bronchoconstriction. Monitor therapy

CYP2D6 Inhibitors (Moderate): May increase the serum concentration of Nebivolol. Monitor therapy

CYP2D6 Inhibitors (Strong): May increase the serum concentration of Nebivolol. Monitor therapy

Diazoxide: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy

Dipyridamole: May enhance the bradycardic effect of Beta-Blockers. Monitor therapy

Disopyramide: May enhance the bradycardic effect of Beta-Blockers. Beta-Blockers may enhance the negative inotropic effect of Disopyramide. Monitor therapy

Dronedarone: May enhance the bradycardic effect of Beta-Blockers. Dronedarone may increase the serum concentration of Beta-Blockers. This likely applies only to those agents that are metabolized by CYP2D6. Management: Use lower initial beta-blocker doses; adequate tolerance of the combination, based on ECG findings, should be confirmed prior to any increase in beta-blocker dose. Consider therapy modification

DULoxetine: Blood Pressure Lowering Agents may enhance the hypotensive effect of DULoxetine. Monitor therapy

Ergot Derivatives: Beta-Blockers may enhance the vasoconstricting effect of Ergot Derivatives. Exceptions: Nicergoline. Consider therapy modification

Fingolimod: Beta-Blockers may enhance the bradycardic effect of Fingolimod. Management: Avoid the concomitant use of fingolimod and beta-blockers if possible. If coadministration is necessary, patients should have overnight continuous ECG monitoring conducted after the first dose of fingolimod. Monitor patients for bradycardia. Consider therapy modification

Floctafenine: May enhance the adverse/toxic effect of Beta-Blockers. Avoid combination

Grass Pollen Allergen Extract (5 Grass Extract): Beta-Blockers may enhance the adverse/toxic effect of Grass Pollen Allergen Extract (5 Grass Extract). More specifically, Beta-Blockers may inhibit the ability to effectively treat severe allergic reactions to Grass Pollen Allergen Extract (5 Grass Extract) with epinephrine. Some other effects of epinephrine may be unaffected or even enhanced (e. g. vasoconstriction) during treatment with Beta-Blockers. Consider therapy modification

Herbs (Hypertensive Properties): May diminish the antihypertensive effect of Antihypertensive Agents. Monitor therapy

Herbs (Hypotensive Properties): May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy

Hypotension-Associated Agents: Blood Pressure Lowering Agents may enhance the hypotensive effect of Hypotension-Associated Agents. Monitor therapy

Insulin: Beta-Blockers may enhance the hypoglycemic effect of Insulin. Monitor therapy

Ivabradine: Bradycardia-Causing Agents may enhance the bradycardic effect of Ivabradine. Monitor therapy

Lacosamide: Bradycardia-Causing Agents may enhance the AV-blocking effect of Lacosamide. Monitor therapy

Levodopa: Blood Pressure Lowering Agents may enhance the hypotensive effect of Levodopa. Monitor therapy

Lidocaine (Systemic): Beta-Blockers may increase the serum concentration of Lidocaine (Systemic). Monitor therapy

Lidocaine (Topical): Beta-Blockers may increase the serum concentration of Lidocaine (Topical). Monitor therapy

Mepivacaine: Beta-Blockers may increase the serum concentration of Mepivacaine. Monitor therapy

Methacholine: Beta-Blockers may enhance the adverse/toxic effect of Methacholine. Avoid combination

Methylphenidate: May diminish the antihypertensive effect of Antihypertensive Agents. Monitor therapy

Midodrine: Beta-Blockers may enhance the bradycardic effect of Midodrine. Monitor therapy

Molsidomine: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy

Naftopidil: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy

Nicergoline: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy

Nicorandil: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy

NIFEdipine: May enhance the hypotensive effect of Beta-Blockers. NIFEdipine may enhance the negative inotropic effect of Beta-Blockers. Monitor therapy

Nitroprusside: Blood Pressure Lowering Agents may enhance the hypotensive effect of Nitroprusside. Monitor therapy

Nonsteroidal Anti-Inflammatory Agents: May diminish the antihypertensive effect of Beta-Blockers. Monitor therapy

Obinutuzumab: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Management: Consider temporarily withholding blood pressure lowering medications beginning 12 hours prior to obinutuzumab infusion and continuing until 1 hour after the end of the infusion. Consider therapy modification

Pentoxifylline: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy

Phosphodiesterase 5 Inhibitors: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy

Propafenone: May increase the serum concentration of Beta-Blockers. Propafenone possesses some independent beta blocking activity. Monitor therapy

Prostacyclin Analogues: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy

Quinagolide: May enhance the hypotensive effect of Blood Pressure Lowering Agents. Monitor therapy

Regorafenib: May enhance the bradycardic effect of Beta-Blockers. Monitor therapy

Reserpine: May enhance the hypotensive effect of Beta-Blockers. Monitor therapy

Rifamycin Derivatives: May decrease the serum concentration of Beta-Blockers. Exceptions: Rifabutin. Monitor therapy

Rivastigmine: May enhance the bradycardic effect of Beta-Blockers. Avoid combination

Ruxolitinib: May enhance the bradycardic effect of Bradycardia-Causing Agents. Management: Ruxolitinib Canadian product labeling recommends avoiding use with bradycardia-causing agents to the extent possible. Monitor therapy

Selective Serotonin Reuptake Inhibitors: May increase the serum concentration of Beta-Blockers. Exceptions: Citalopram; Escitalopram; FluvoxaMINE. Monitor therapy

Sulfonylureas: Beta-Blockers may enhance the hypoglycemic effect of Sulfonylureas. Cardioselective beta-blockers (eg, acebutolol, atenolol, metoprolol, and penbutolol) may be safer than nonselective beta-blockers. All beta-blockers appear to mask tachycardia as an initial symptom of hypoglycemia. Ophthalmic beta-blockers are probably associated with lower risk than systemic agents. Monitor therapy

Theophylline Derivatives: Beta-Blockers (Beta1 Selective) may diminish the bronchodilatory effect of Theophylline Derivatives. Management: Monitor for reduced theophylline efficacy during concomitant use with any beta-blocker. Beta-1 selective agents are less likely to antagonize theophylline than nonselective agents, but selectivity may be lost at higher doses. Monitor therapy

Tofacitinib: May enhance the bradycardic effect of Bradycardia-Causing Agents. Monitor therapy

Yohimbine: May diminish the antihypertensive effect of Antihypertensive Agents. Monitor therapy

Adverse Reactions

Cardiovascular: Peripheral edema (1%), bradycardia (?1%), chest pain (?1%)

Central nervous system: Headache (6% to 9%), fatigue (dose related; 2% to 5%), dizziness (2% to 4%), insomnia (1%)

Dermatologic: Rash (?1%)

Endocrine & metabolic: HDL levels decreased, hypercholesterolemia, triglyceride levels increased, uric acid levels increased

Gastrointestinal: Diarrhea (dose related; 2% to 3%), nausea (1% to 3%), abdominal pain

Hematologic: Platelet count decreased

Neuromuscular & skeletal: Paresthesia, weakness

Renal: BUN increased

Respiratory: Dyspnea (?1%)

<1% (Limited to important or life-threatening): Acute pulmonary edema, acute renal failure, allergic vasculitis, angioedema, AST increased, ALT increased, AV block (second and third degree), bilirubin increased, bronchospasm, claudication, erectile dysfunction, hepatic function abnormal, hypersensitivity reaction, MI, peripheral ischemia, pruritus, psoriasis, Raynaud's phenomenon, skin disorder, somnolence, syncope, thrombocytopenia, urticaria, vertigo, vomiting

Warnings/Precautions

Concerns related to adverse effects:

• Anaphylactic reactions: Use caution with history of severe anaphylaxis to a variety of allergens; patients taking beta-blockers may become more sensitive to repeated challenges. Treatment of anaphylaxis (eg, epinephrine) in patients taking beta-blockers may be ineffective or promote undesirable effects.

• Bronchospastic disease: In general, patients with bronchospastic disease should not receive beta-blockers; for patients with bronchospastic disease who do not respond to or cannot tolerate other therapies, initial low doses of beta 1 - selective nebivolol may be employed and used cautiously with close monitoring. Ensure patient has an inhaled beta 2 - agonist immediately available.

• Diabetes: Use with caution in patients with diabetes mellitus; may potentiate hypoglycemia and/or mask signs and symptoms.

• Heart failure (HF): Note: Nebivolol has not been shown to reduce morbidity or mortality in the general HF population; only beta-blockers proven to reduce mortality (ie, bisoprolol, carvedilol, or extended-release metoprolol succinate) should be used in the treatment of heart failure. Use with caution in patients with compensated HF and monitor for a worsening of the condition. If condition worsens, consider temporary discontinuation or dosage reduction of nebivolol. Patients should be stabilized on HF regimen prior to initiation of beta-blocker. Beta-blocker therapy should be initiated at very low doses with gradual and very careful titration. Adjustment of other medications (ACE inhibitors and/or diuretics) may be required.

• Hepatic impairment: Use with caution in patients with hepatic impairment; dosage adjustment required with moderate impairment (Child-Pugh class B). Use is contraindicated in patients with Child-Pugh class C hepatic impairment.

• Myasthenia gravis: Use with caution in patients with myasthenia gravis.

• Peripheral vascular disease (PVD) and Raynaud's disease: Can precipitate or aggravate symptoms of arterial insufficiency in patients with PVD and Raynaud's disease. Use with caution and monitor for progression of arterial obstruction. Canadian labeling contraindicates use in severe peripheral vascular disease.

• Pheochromocytoma (untreated): Adequate alpha-blockade is required prior to use of any beta-blocker.

• Psoriasis: Beta-blocker use has been associated with induction or exacerbation of psoriasis, but cause and effect have not been firmly established.

• Psychiatric disease: Use with caution in patients with a history of psychiatric illness; may cause or exacerbate CNS depression.

• Renal impairment: Use with caution in patients with renal impairment; dosage adjustment required with severe renal impairment (CrCl <30 mL/minute). Nebivolol has not been evaluated in dialysis-dependent patients.

• Thyroid disease: May mask signs of hyperthyroidism (eg, tachycardia). If thyrotoxicosis is suspected, carefully manage and monitor; abrupt withdrawal may exacerbate symptoms of hyperthyroidism or precipitate thyroid storm.

Concurrent drug therapy issues:

• Drug-drug interactions: Potentially significant interactions may exist, requiring dose or frequency adjustment, additional monitoring, and/or selection of alternative therapy. Consult drug interactions database for more detailed information.

• Elderly: Bradycardia may be observed more frequently in elderly patients (>65 years of age); dosage reductions may be necessary.

• Abrupt withdrawal: Beta-blocker therapy should not be withdrawn abruptly (particularly in patients with coronary artery disease), but gradually tapered over 1-2 weeks to avoid acute tachycardia, hypertension, and/or ischemia. Severe exacerbation of angina, ventricular arrhythmias, and myocardial infarction (MI) have been reported following abrupt withdrawal of beta-blocker therapy. Temporary but prompt resumption of beta-blocker therapy may be indicated with worsening of angina or acute coronary insufficiency.

• Major surgery: Chronic beta-blocker therapy should not be routinely withdrawn prior to major surgery.

Monitoring Parameters

Blood pressure, ECG; serum glucose (in diabetic patients)

Pregnancy Risk Factor

Pregnancy Considerations

Adverse events have been observed in some animal reproduction studies. Adverse events, such as fetal/neonatal bradycardia, hypoglycemia, reduced birth weight, have been observed following in utero exposure to beta-blockers as a class. Adequate facilities for monitoring infants at birth is generally recommended.

Untreated chronic maternal hypertension and preeclampsia are also associated with adverse events in the fetus, infant, and mother (ACOG 2015; Magee 2014). Although beta-blockers may be used when treatment of hypertension in pregnancy is indicated, agents other than nebivolol are preferred (ACOG 2013; Magee 2014; Regitz-Zagrosek 2011).

Patient Education

• Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)

• Patient may experience headache or loss of strength and energy. Have patient report immediately to prescriber signs of low blood sugar (dizziness, headache, fatigue, feeling weak, shaking, a fast heartbeat, confusion, hunger, or sweating), angina, severe dizziness, passing out, shortness of breath, excessive weight gain, swelling of arms or legs, arrhythmia, bradycardia, or burning or numbness feeling (HCAHPS).

• Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.

Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for healthcare professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience and judgment in diagnosing, treating and advising patients.

Holoshape Products, Inc, Multigram

Imaging

Mastering, Tooling, and Setup

We offer the widest variety of holographic imaging techniques available today. From simple pattern/logo surface images to the most sophisticated security holograms, we can meet your imaging needs.

Creating a custom hologram starts with your concepts and project requirements. Descriptions and illustartions of the six most common types of holographic imaging are below.

2D Holograms and Gratings

2D holograms use the characteristic "rainbow" coloration directly on the surface of a label, ID pouch, etc. offering a bright active image surface. 2D hologram images are primarily used for patterns for IDs, packaging applications, and backgrounds for overprinted labels.

Multi-Level Graphic Holograms

Multi-level graphic holograms create 3D images by placing 2D graphic images on different levels. Commonly called "2D/3D" holograms, their brightness and vivid colors make this technique very popular for logos and character properties.

3D Holograms

3D holograms record actual 3D objects and models created specifically for the composition. 2D graphics are often used to accent or add additional depth to the image.

Dot Matrix Holograms

Dot matrix holograms are produced from computer generated images that are pixelated. Each pixel, or dot, can be individually oriented. When combined, the many dots of the hologram create the image or images that change as the hologram is tipped in the light. Resolutions range from 100 DPI to 1000+ DPI.

Stereogram Holograms

Versitile stereograms are produced from film or computer generated images. This type of hologram is used to capture 3D images of people and large objects. Animation and multi-level graphic images are also produced using this method.

Multigram®

Multigram holograms are produced using a combination of holographic imaging techniques. Primarily used for security applications, these holograms require a sophisticated lab that can produce a number of hologram image styles and have the ability to combine these diverse styles into a single image.

Setup, Mastering, and Tooling Costs

One time costs to produce custom hologram images start at $2250.00 US and cost $8,500.00 US for multigram security projects. Each hologram project will be qualified and quoted on a per job basis.

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