Dramavol Para Que Sirve, Dramavol

Dramavol

Tenga especial cuidado durante el embarazo .

Revise siempre que no sea alergico a ninguno de los componentes de Dramavol . podria poner en peligro su salud

Recuerda antes de tomar este medicamento consultar siempre con su medico, la informacion que ofrecemos es orientativa y no sustituye en ningun caso la de su medico u otro profesional de la salud.

Prospecto e indicaciones

COMPOSICION

Cada Ampolla contiene: Dimenhidrinato 50 mg Vehiculo, c. s.p. 2 ml.

INDICACIONES

Vomitos, nauseas, vertigos provocados por la enfermedad de Meniere o por otras circunstancias, migrana, alcoholismo, embarazo, estados posquirurgicos, radiacion.

DOSIS Y VIA DE ADMINISTRACION

Dosis postanestesia y postoperatoria, dosis postradia­cion. Via intramuscular: Administrar una ampolla cada 4 horas. Via endovenosa lenta: Diluir una ampolla en 10 ml de solucion salina y administrar cada 4 horas.

CONTRAINDICACIONES

No usarlo en neonatos ni concomitante con alcohol, hipersensibilidad a algun componente de la formula.

PRECAUCIONES

Se recomienda no conducir vehiculos ni maquinaria que requiera concen­tracion. Puede producir somnolencia.

PRESENTACION

Caja con estuche de seguridad que contiene: ampolla con 2 ml, jeringa descartable y algodon con alcohol.

Baca Dan Jaga Kesehatan Selalu Ya Khasiat Benzolac Buat Jerawat, Benzolac Cl

Khasiat benzolac buat jerawat

Wajah cantik dan cakep adalah idaman, bagaimana kalau wajah berjerawat?…oh, betapa sedihnya. Hari ini, saya buatkan artikel khusus untuk mengatasi jerawat. Banyak sekali tulisan mengenai jerawat tapi belum pernah yang sukses membersihkan diri dengan namanya “ JERAWAT ”. Untuk mengatasi masalah jerawat tentu harus dari ahlinya. Dan kebetulan saya sudah ber-wawancara dengan dokter umum sekaligus dokter ahlinya kecantikan bagi pria dan wanita. Beliau bernama dr. adibroto. seorang dokter yang bekerja di Madiun hingga kini masih banyak yang ber-konsultasi dengannya. Dan saya menyiapkan artikel ini untuk anda asli dari saya hasil wawancara/konsultasi dari ahlinya, bukan dari karya copy paste. Ingin menghilangkan jerawat? ikuti artikel berikut ini. Apakah jerawat itu ? Ya, jerawat adalah semacam penyakit kulit. karena kondisi kulit yang tidak seimbang hormonnya, akibatnya terbentuklah penebalan pada permukaan kulit dan menutupi pori – pori wajah yang berupa bintik besar yang tidak sedap dipandang.

Ada Berbagai banyak jenis jerawat, timbulnya jerawat utamanya pada jenis kulit yang berminyak, dengan ciri2 sebagai berikut :

Kulit menghasilkan minyak berlebih ( bisa mengkilat )

Pori – Pori melebar dan permukaan kulit tampak kasar.

Kulit cenderung bernoda hitam, berbintik – bintik dan berjerawat.

Kapan terbentuknya jerawat. kelenjar minyak yang terus memproduksi sebum yang menyebabkan folikel membengkak, sehingga timbul noda – noda putih. Setelah noda putih terkena udara akan berubah menjadi noda hitam. Noda hitam berasal dari pigmen kulit yang normal, dan karena bakteri pada kulit normal(p. acnes) memulai berkembang biak dengan cepat dalam tolikel rambut yang tersumbat. Jerawat yang membatu merupakan jerawat yang besar dan menyakitkan yang bisa mengakibatkan bekas luka yang permanen. Bagaimana cara mengatasi jerawat tersebut? ikuti langkah berikut ini :

1. Cegah kulit anda jangan sampai menambah jerawat yg sudah ada. Apabila berjerawat :

Cegah jangan sampai terjadi iritasi, karena akibat penggunaan salep jerawat secara berlebihan.

Basuh wajah anda 2-3 kali sehari. Pertahankan kadar ph wajah anda. Cara membasuh wajah pun jangan terlalu sering menggosok wajah anda terlalu keras. Misalnya dengan handuk / tisu. Basuhlah wajah anda dengan lembut, ingat jerawat karena pasti ada iritasi kulit.

2. Pembersihan Wajah

Gunakan cleansing cair ( bukan cleansing milk )

Carilah di apotek terdekat, tanyakan apakah tersedia cleansing kulit berjerawat ( Kalau kesulitan, saya menyediakan cleansing jerawat + kompres dengan harga murah belum termasuk ongkos kirim, kirim email ke saya [email protected] com ) atau produk jadi di apotik yg mengandung AHA (alphahidroxyacid) misalnya exfoliac cleansing foom ve with AHA. Saya menyediakannya bagi anda yg minat.

Gunakan obat jerawat dalam bentuk cair/lotion. Dipakai malam hari saja. (juga saya menyediakan) dan sabun jerawat khusus (saya menyediakan juga). Produk jadi yg di apotik misalnya Banzolac jeli, Benzolac CL, Notace dan lainnya.

Membersihkan wajah dua kali sehari, kalau anda mempunyai cleansing milk, dalam penggunaanya encerkan dahulu dengan air.

3 . Bila akan tumbuh jerawat lagi, kompreslah es batu pada tempat yang akan timbulnya jerawat, bungkuslah bongkahan es batu dan kompreslah selama beberapa menit. bisa diulang 3 kali sehari.

4. Konsumsilah air, minimal setengah dari berat anda. Wow, memang sebanyak itulah yang dibutuhkan, Air bukanlah menghilangkan jerawat tapi untuk membantu kulit anda tetap sehat dan bebas jerawat.

5 . infeksi. Apabila ada di kulit wajah anda, gunakan antibiotika. Harus menggunakan resep dokter, pakailah yang generik, dari golongan jenis doxsacyclin 50 mg per hariatau golongan clindamycin300 mg sekali sehariatau obat olesyg khususiunfeksi (gunakan clindamycyn dalam bentuk gel, atau golongan erytromycin (AKNEMYCIN SOL( R).ERYMED SOL (R),ERYDerm(r),mungkin bisa dibeli tanpa resap dokter

6. pori pori yg besar, kencangkan pori pori itu karena akan mengurangi produksi minyak secara berlebih yg menjadi penyebab jerawat. Kalau pori anda besar akan sangat mengganggu, saya menyediakan produk untuk mengencangkan kulit dan mengecilkan pori pori (produk terbatas)

7 . konsumsi vitamin yg mengandung tembaga dan mangan setiap hariserta zeng yg merupakan zat efektif dalam perawatan jerawat yg juga merupakan proses penyembuhanjaringan& membantu mencegahnya timbulnya bekas luka. MULTIVITAMIN yg tersedia di APOTEK (ZEGAVIT(R).bECOM ZET (R).Benovit M, VIDAYLIN M dan masih banyak lagi. pemakaian obat sekali sehari

8.kurangi diet lemak, pasti anda tau yg dimaksud lemak, jenis masakan yg berlemak mis daging2an. kacang juga kurangi konsumsi gula, waspadalah terhadap makanan ringan/cemilan.

9. Hindari make up berlebih, mulai penggunaan alas bedak/hindari. gunakan make up berbahan dasar air & cukup gunakan bedak tabur saja.

10.Hindari sinar matahari ; pakailah lotion penahan sinar matahari dipakai saat kita berada dilar rumah, utamanya siang hari. Gunakan Sun Block SPF dIATAS 20.

11 Hindari memencet jerewat

13 Kurangi menyentuh wajah

14 Hindari penggunaan strip pembuka pori pori

15 Jangan terlalu sering FACIAL …INGAT IRITASI!!

ANDA BOLEH MENCOBA SEMUA LANGKAH PENGOBATAN YG BISA ANDA LAKUKANSENDIRI, SELAMA LANGKAH LANGKAH TIDAK MENIMBULKAN EFEK YG MERUGIKAN BAGI ANDA.

S ELAMAT MENJADI CANTIK KEMBALI………

Flodemex, Flodemex

Flodemex

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Investors - Hysan Development Company Limited, Hysan

Investors

We are committed to maintaining a policy of open and timely disclosure of relevant information on our activities to shareholders and other stakeholders, subject to applicable legal requirements.

In line with international best practices, we communicate with shareholders through our annual and interim reports, annual and other general meetings, regular analyst and press briefings, press releases, disclosures to the Stock Exchange and relevant regulatory bodies, as well as the Group’s website.

2016 Hysan Development Co. Ltd. Interim Results Analyst Briefing Live Webcast

Date: 2 August 2016 (Tuesday) Starting time: 5pm

Due to Typhoon NIDA, we will have the following special arrangement: If Typhoon Signal No.8 or above and/or the Black Rainstorm Warning signal is still in place at 12:00 (noon) on 2 August, the webcast will be re-scheduled to the next business day (3 August) and will remain at 5:00pm. Otherwise, the webcast will start at 5:00 pm on 2 August, 2016.

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©2014 Hysan. All Rights Reserved.

Clinical Experience With Spersadex Comp, Spersadex

Cesk Slov Oftalmol. 1997 Feb;53(1):49-56.

Abstract

The preparation Spersadex comp. gtt. was tested on three groups of patients (60 patients, 109 eyes) in order to assess its effectiveness in indications outlined by the manufacturer. The preparation has a very favourable antimicrobial, and antiphlogistic action. It proved very effective also in the treatment of chlamydial infections and in the postoperative treatment the combination of the antiphlogistic effect and the antibiotic action proved very useful, though tested only in small groups of patients. Spersadex comp. gtt. is a very effective preparation, well tolerated by patients and it supplements in a useful way the range of eye drops by a new antibiotic-corticoid combination.

PMID

9213525 [PubMed - indexed for MEDLINE]

Article in Czech.

Benison, Benison

benison

Did You Know?

Benison and its synonym "benediction" share more than a common meaning; the two words come from the same root, the Latin benedicere, meaning "to bless." ("Benedicere" comes from the Latin bene dicere - "to speak well of" - a combination of the Latin bene, meaning "well," and "dicere," to say.) Of the two words, "benediction" is more common today, but "benison" has a longer history in English. Records show that "benison" has been used in our language since the 14th century. "Benediction" didn't appear in print until nearly a century later.

Origin and Etymology of benison

Middle English beneson, from Anglo-French beneicon, from Late Latin benediction-, benedictio

First Known Use: 14th century

Rheugesic, Rheugesic

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Rheugesic (Piroxicam)

Topiramate Glenmark 100mg Film-Coated Tablets, Toramat

TOPIRAMATE GLENMARK 100MG FILM-COATED TABLETS

Transcript

Topiramate 25-200mg Insert Open Size: 180 x 420 mm (Fldg. Size: 180 x 35 mm) (Paper: 40 gsm Bible Paper) Date: 02.05.2014 (Front) V2 (Remarks: var to add 200’s blister pack GPEL a/ws)

PACKAGE LEAFLET: INFORMATION FOR THE USER Topiramate Glenmark 25mg film-coated tablets Topiramate Glenmark 50mg film-coated tablets Topiramate Glenmark 100mg film-coated tablets Topiramate Glenmark 200mg film-coated tablets Topiramate Read all of this leaflet carefully before you start taking this medicine because it contains important information for you. • Keep this leaflet. You may need to read it again. • If you have any further questions, ask your doctor or pharmacist. • This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours. • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4. What is in this leaflet: 1. What Topiramate tablets are and what they are used for 2. What you need to know before you take Topiramate tablets 3. How to take Topiramate tablets 4. Possible side effects 5. How to store Topiramate tablets 6. Contents of the pack and other information 1. WHAT TOPIRAMATE TABLETS ARE AND WHAT THEY ARE USED FOR Topiramate belongs to a group of medicines called “antiepileptic medicines”. It is used: • alone to treat seizures in adults and children over age 6 • with other medicines to treat seizures in adults and children aged 2 years and above • to prevent migraine headaches in adults 2. WHAT YOU NEED TO KNOW BEFORE YOU TAKE TOPIRAMATE TABLETS Do not take Topiramate tablets • If you are allergic to topiramate or any of the other ingredients of this medicine (listed in section 6) • for migraine prevention if you are pregnant or you are able to become pregnant but you are not using effective contraception (see section ‘pregnancy and breastfeeding’ for further information). If you are not sure if the above applies to you, talk to your doctor or pharmacist before using this medicine. Warnings and precautions Talk to your doctor or pharmacist before taking this medicine if you: • have kidney problems, especially kidney stones, or are getting kidney dialysis • have a history of blood and body fluid abnormality (metabolic acidosis) • have liver problems • have eye problems, especially glaucoma • have a growth problem • are on a high fat diet (ketogenic diet) • are pregnant or could become pregnant (see section ‘pregnancy and breastfeeding’ for further information) If you are not sure if any of the above applies to you, talk to your doctor or pharmacist before using this medicine. It is important that you do not stop taking your medicine without first consulting your doctor. You may lose weight if you use topiramate so your weight should be checked regularly when using this medicine. If you are losing too much weight or a child using this medicine is not gaining enough weight, you should consult your doctor. A small number of people being treated with anti-epileptics such as topiramate have had thoughts of harming or killing themselves. If at any time you have thoughts like this, immediately contact your doctor. Topiramate might decrease perspiration, especially in children, causing body temperature to rise during exercise and exposure to warm environments. Therefore, it is important to drink plenty of water during the treatment with topiramate, especially if you are taking exercise or the weather is hot to reduce the risk of heat-related adverse events, like headache and nausea. Other medicines and Topiramate tablets Tell your doctor or your pharmacist if you are taking, have recently taken or might take any other medicines, including medicines obtained without a prescription, vitamins and herbal medicines. Topiramate and certain other medicines can affect each other. Sometimes the dose of some of your other medicines or topiramate will have to be adjusted. Especially, tell your doctor or pharmacist if you are taking: • other medicines that impair or decrease your thinking, concentration, or muscle coordination (e. g. central nervous system depressant medicines such as muscle relaxants and sedatives). • birth control pills. Topiramate may make your birth control pills less effective. Tell your doctor if your menstrual bleeding changes while you are taking birth control pills and Topiramate. Keep a list of all the medicines you take. Show this list to your doctor and pharmacist before you start a new medicine. Other medicines you should discuss with your doctor or pharmacist include other antiepileptic medicines, risperidone, lithium, hydrochlorothiazide, metformin, pioglitazone, glyburide, amitriptyline, propranolol, diltiazem, venlafaxine, flunarazine, St. John’s wort (Hypericum perforatum) (a herbal preparation used to treat depression). If you are not sure if any of the above applies to you, talk to your doctor or pharmacist before using this medicine. Topiramate tablets with food and drink You can take the tablets with or without food. Drink plenty of fluids during the day to prevent kidney stones while taking topiramate. You should avoid drinking when taking topiramate. Pregnancy, breast-feeding and fertility If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine. Your doctor will decide if you can take topiramate. As with other anti-epilepsy medicines, there is a risk of harm to the unborn child if topiramate is used during pregnancy. Make

sure you are very clear about the risks and the benefits of using topiramate for epilepsy during pregnancy. You should not take topiramate for migraine prevention if you are pregnant or you are able to become pregnant and you are not using effective contraception. Mothers who breastfeed while taking topiramate must tell the doctor as soon as possible if the baby experiences anything unusual. Ask your doctor or pharmacist for advice before taking any medicine. Driving and using machines Dizziness, tiredness, and vision problems may occur during treatment with topiramate. Do not drive or use any tools or machines without talking to your doctor first. Topiramate tablets contains lactose If you have been told by your doctor that you have intolerance to some sugars, contact your doctor before taking this medicinal product. Topiramate tablets 50mg film-coated tablets contain sunset yellow which may cause allergic reactions. The bottles of Topiramate tablets contain a canister of silica gel desiccant. The desiccant canister must not be swallowed. 3. HOW TO TAKE TOPIRAMATE TABLETS Always take Topiramate tablets exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure. • Take Topiramate tablets exactly as prescribed. Your doctor will usually start you on a low dose of topiramate and slowly increase your dose until the best dose is found for you. • Topiramate tablets are to be swallowed whole. Avoid chewing the tablets as they may leave a bitter taste. • Topiramate tablets can be taken before, during, or after a meal. Drink plenty of fluids during the day to prevent kidney stones while taking these tablets. If you take more Topiramate tablets than you should • See a doctor right away. Take the medicine pack with you. • You may feel sleepy, tired or less alert, lack coordination, have difficulty speaking or concentrating, have double or blurred vision, feel dizzy due to low blood pressure, feel depressed or agitated, have abdominal pain or seizures (fits). Overdose can happen if you are taking other medicines together with Topiramate tablets If you forget to take Topiramate tablets • If you forget to take a dose, take it as soon as you remember. However if it is almost time for your next dose, skip the missed dose and continue as usual. If you miss two or more doses, contact your doctor. • Do not take a double dose (two doses at the same time) to make up for a forgotten dose. If you stop taking Topiramate tablets DO NOT STOP taking this medicine unless told to do so by your doctor. Your symptoms may return. If your doctor decides to stop this medication, your dose may be decreased gradually over a few days. If you have any further questions on the use of this product ask your doctor or pharmacist. 4. POSSIBLE SIDE EFFECTS Like all medicines, Topiramate tablets can cause side effects, although not everybody gets them. Tell your doctor, or seek medical attention immediately if you have the following side effects: Very common (may affect more than 1 in 10 people) • Depression (new or worse) Common (may affect up to 1 in 10 people) • Seizures (fits) • Anxiety, irritability, changes in mood, confusion, disorientation • Problems with concentration, slowness of thinking, loss of memory, problems with memory (new onset, sudden change or increased severity) • Kidney stone, frequent or painful urination Uncommon (may affect up to 1 in 100 people) • Increased acid level in the blood (may cause troubled breathing including shortness of breath, loss of apetite, nausea, vomiting, excessive tiredness, and fast or uneven heart beats) • Decreased or loss of sweating • Having thoughts of serious self-harm, trying to cause serious self-harm Rare :(may affect up to 1 in 1,000 people) • Glaucoma – blockage of fluid in eye causing increased pressure in the eye, pain or decreased vision Other side effects include the following, if they get serious, please tell your doctor or pharmacist: Very common (may affect more than 1 in 10 people) • Stuffy, runny nose or sore throat • Tingling, pain and/or numbness of various body parts • Sleepiness, tiredness • Dizziness • Nausea, diarrhoea • Weight loss

Topiramate 25-200mg Insert Open Size: 180 x 420 mm (Fldg. Size: 180 x 35 mm) (Paper: 40 gsm Bible Paper) Date: 02.05.2014 (Back) V2 (Remarks: var to add 200’s blister pack GPEL a/ws)

Common (may affect up to 1 in 10 people) • Anaemia (low blood count) • Allergic reaction (such as skin rash, redness, itching, facial swelling, hives) • Loss of appetite, decreased appetite • Aggression, agitation, anger • Difficulty falling or staying asleep • Problems with speech or speech disorder, slurred speech • Clumsiness or lack of coordination, feeling of unsteadiness when walking • Decreased ability to complete routine tasks • Decreased, loss of, or no sense of taste • Involuntary trembling or shaking; rapid, uncontrollable movements of the eyes • Visual disturbance, such as double vision, blurred vision, decreased vision, difficulty focusing • Sensation of spinning (vertigo), ringing in the ears, ear pain • Shortness of breath • Nose bleeds • Fever, not feeling well, weakness • Vomiting, constipation, abdominal pain or discomfort, indigestion, stomach or intestinal infection • Dry mouth • Hair loss • Itching • Joint pain or swelling, muscle spasms or twitching, muscle aches or weakness, chest pain • Weight gain Uncommon (may affect up to 1 in 100 people) • Decrease in platelets (blood cells that help stop bleeding), decrease in white blood cells that help to protect you against infection, decrease in potassium level in the blood • Increase in liver enzymes, increase in eosinophils (a type of white blood cell) in the blood • Swollen glands in the neck, armpit, or groin • Increased appetite • Elevated mood • Hearing, seeing, or feeling things that are not there, severe mental disorder (psychosis) • Showing and/or feeling no emotion, unusual suspiciousness, panic attack • Problems with reading, speech disorder, problems with handwriting • Restlessness, hyperactivity • Slowed thinking, decreased wakefulness or alertness • Reduced or slow body movements, involuntary abnormal or repetitive muscle movements • Fainting • Abnormal sense of touch; impaired sense of touch • Impaired, distorted, or no sense of smell • Unusual feeling or sensation that may precede a migraine or a certain type of seizure • Dry eye, sensitivity of the eyes to light, eyelid twitching, watery eyes • Decreased or loss of hearing, loss of hearing in one ear • Slow or irregular heartbeat, feeling your heart beating in your chest • Low blood pressure, low blood pressure upon standing (consequently, some people taking Topamax may feel faint, dizzy, or may pass out when they stand up or sit up suddenly) • Flushing, feeling warm • Pancreatitis (inflammation of the pancreas) • Excessive passing of gas or wind, heartburn, abdominal fullness or bloating • Bleeding gums, increased saliva, drooling, breath odour • Excessive intake of fluids, thirst • Skin discolouration • Muscle stiffness, pain in side • Blood in urine, incontinence (lack of control) of urine, urgent desire to urinate, flank or kidney pain • Difficulty getting or keeping an erection, sexual dysfunction • Flu-like symptoms • Cold fingers and toes • Feeling drunk • Learning disability Rare :(may affect up to 1 in 1,000 people) • Abnormally elevated mood • Loss of consciousness • Blindness in one eye, temporary blindness, night blindness • Lazy eye • Swelling in and around the eyes • Numbness, tingling and colour change (white, blue then red) in fingers and toes when exposed to the cold • Inflammation of the liver, liver failure • Stevens Johnson syndrome, a potentially life-threatening condition that may present with sores in multiple mucosal sites (such as the mouth, nose, and eyes), a skin rash, and blistering • Abnormal skin odour • Discomfort in your arms or legs • Kidney disorder • Increased acid level in the blood • Not known (frequency cannot be estimated from the available data) Maculopathy is a disease of the macula, the small spot in the retina where vision is keenest. You should call your doctor if you notice a change or decrease in your vision. • Swelling of the conjunctiva of the eye. • Toxic epidermal necrolysis which is a more severe form of Stevens-Johnson syndrome, characterized by widespread blistering and sloughing of the outer layers of the skin (see rare side effects) • Cough. Children and adolescents The side effects in children are generally similar to those seen in adults. However, some side effects are either seen more frequently in children and/or can be more severe in children than in adults. Side effects which may be more severe include decreased or loss of sweating and increase of the acid level in the blood. Side effects which may occur more frequently in children include upper respiratory tract illnesses.

Reporting of side effects If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via www. mhra. gov. uk/yellowcard. By reporting side effects you can help provide more information on the safety of this medicine. 5. HOW TO STORE TOPIRAMATE TABLETS Keep this medicine out of the sight and reach of children. Do not use Topiramate tablets after the expiry date which is stated on the blister/bottle and the outer carton. The expiry date refers to the last day of that month. Plastic bottles • Do not store above 25°C. • Keep the container tightly closed in order to protect from moisture. Blisters • Do not store above 25°C. • Store in the original blister package in order to protect from moisture. Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help to protect the environment. 6. CONTENTS OF THE PACK AND OTHER INFORMATION What Topiramate Tablets contain - The active substance is topiramate. Each film-coated tablet contains 25 mg, 50 mg, 100 mg, 200 mg of topiramate. - The other ingredients are: • tablet core Lactose monohydrate, microcrystalline cellulose (E460), pregelatinised maize starch, sodium starch glycollate (Type A), magnesium stearate. • tablet coating - for Topiramate Tablets 25mg film-coated tablets, hypromellose, macrogol 400, polysorbate 80, titanium dioxide (E171). - for Topiramate Tablets 50mg film - coated tablets, hypromellose, macrogol 400, polysorbate 80, sunset yellow lake (E110). titanium dioxide (E171) and yellow iron oxide (E172). - for Topiramate Tablets 100mg and 200mg fim-coated tablets, hypromellose, macrogol 400, polysorbate 80, titanium dioxide (E171), red iron oxide (E172) and yellow iron oxide (E172). What Topiramate Tablets look like and contents of the pack Film-coated tablet Topiramate Tablets 25mg film-coated tablets: round, white, film-coated tablets with ‘G’ engraved on one side and ‘25’ on the other. Topiramate Tablets 50mg film-coated tablets. round, yellow, film-coated tablets with ‘G’ engraved on one side and ‘50’ on the other. Topiramate Tablets 100mg film-coated tablets. round, yellow, film-coated tablets with ‘G’ engraved on one side and ‘100’ on the other. Topiramate Tablets 200mg film-coated tablets. round, pink, film-coated tablets with ‘G’ engraved on one side and ‘200’ on the other. Topiramate Tablets 25mg, 50mg, 100mg and 200mg filmcoated tablets are available in plastic bottles with tamperproof, flip-open caps containing 20, 28, 30, 50, 56, 60, 100 and 200* tablets and a dessicant cannister. The desiccant must not be swallowed. Topiramate Tablets 25mg, 50mg, 100mg and 200mg filmcoated tablets are also available in aluminium foil blisters of 4, 7, 10, 14, 20, 28, 30, 50, 56, 60, 84, 90, 100, 120 and 200* tablets. *Not all packs sizes may be marketed. Marketing Authorisation Holder and Manufacturer Marketing Authorisation Holder: Glenmark Pharmaceuticals Europe Ltd, Laxmi House, 2-B Draycott Avenue, Kenton, Harrow, Middlesex, HA3 OBU, United Kingdom Manufacturer: Glenmark Pharmaceuticals s. r.o.,Hvezdova 1716/2b, 140 78 Prague 4, Czech Republic Tillomed Laboratories Limited, 3 Howard Road, Eaton Socon, St. Neots, Cambridgeshire, PE19 8ET, United Kingdom Glenmark Pharmaceuticals Europe Ltd. Building 2, Croxley Green Business Park, Croxley Green, Hertfordshire, WD18 8YA, United Kingdom This medicinal product is authorised in the Member States of the EEA under the following names: DE Topiramat Glenmark 25 /50 /100 /200 mg Filmtabletten CZ Topimark 25 /50 /100 mg NL Topiramaat Glenmark 25 /50 /100 /200 mg Filmomhulde tabletten PL Toramat RO Torlepta 25 /50 /100 mg SK Topimark 25 /50 /100 /200 mg UK Topiramate 25 /50 /100 /200 mg Film-coated tablets This leaflet was last revised in: 05/2014

Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

Percocet (Oxycodone And Acetaminophen) Drug Information Medication Guide And Patient Information - P

PATIENT INFORMATION

The following information should be provided to patients receiving PERCOCET tablets by their physician, nurse, pharmacist, or caregiver:

Do not take PERCOCET if you are allergic to any of its ingredients.

If you develop signs of allergy such as a rash or difficulty breathing stop taking PERCOCET and contact your healthcare provider immediately.

Do not take more than 4000 milligrams of acetaminophen per day. Call your doctor if you took more than the recommended dose.

Patients should be aware that PERCOCET tablets contain oxycodone. which is a morphinelike substance.

Patients should be instructed to keep PERCOCET tablets in a secure place out of the reach of children. In the case of accidental ingestions, emergency medical care should be sought immediately.

When PERCOCET tablets are no longer needed, the unused tablets should be destroyed by flushing down the toilet.

Patients should be advised not to adjust the medication dose themselves. Instead, they must consult with their prescribing physician.

Patients should be advised that PERCOCET tablets may impair mental and/or physical ability required for the performance of potentially hazardous tasks (e. g. driving, operating heavy machinery).

Patients should not combine PERCOCET tablets with alcohol, opioid analgesics, tranquilizers, sedatives, or other CNS depressants unless under the recommendation and guidance of a physician. When co-administered with another CNS depressant, PERCOCET tablets can cause dangerous additive central nervous system or respiratory depression, which can result in serious injury or death.

The safe use of PERCOCET tablets during pregnancy has not been established; thus, women who are planning to become pregnant or are pregnant should consult with their physician before taking PERCOCET tablets.

Nursing mothers should consult with their physicians about whether to discontinue nursing or discontinue PERCOCET tablets because of the potential for serious adverse reactions to nursing infants.

Patients who are treated with PERCOCET tablets for more than a few weeks should be advised not to abruptly discontinue the medication. Patients should consult with their physician for a gradual discontinuation dose schedule to taper off the medication.

Patients should be advised that PERCOCET tablets are a potential drug of abuse. They should protect it from theft, and it should never be given to anyone other than the individual for whom it was prescribed.

Last reviewed on RxList: 12/18/2015 This monograph has been modified to include the generic and brand name in many instances.

Percocet FDA Prescribing Information

Additional Percocet Information

Percocet - User Reviews

Percocet User Reviews

Now you can gain knowledge and insight about a drug treatment with Patient Discussions.

Here is a collection of user reviews for the medication Percocet sorted by most helpful.

See User Reviews

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Tizanidine Uses, Dosage, Side Effects, Tizanidinum

Tizanidine

What is tizanidine?

Tizanidine is a short-acting muscle relaxer. It works by blocking nerve impulses (pain sensations) that are sent to your brain.

Tizanidine is used to treat spasticity by temporarily relaxing muscle tone.

Tizanidine may also be used for purposes other than those listed in this medication guide.

Important information

Tizanidine is a short-acting medication that should be taken only for daily activities that require relief from muscle spasticity.

Do not take tizanidine if you are also taking the antidepressant fluvoxamine (Luvox), or the antibiotic ciprofloxacin (Cipro). Do not use tizanidine at a time when muscle tone is needed to assure safe balance and movement for certain activities. In some situations, it may endanger your physical safety to be in a state of reduced muscle tone.

Switching between tizanidine tablets and capsules, or changing the way you take it with regard to eating, can cause an increase in side effects or a decrease in therapeutic effect. Follow your doctor's instructions carefully. After making any changes in how you take tizanidine, contact your doctor if you notice any change in how well the medicine works or if it causes increased side effects.

Do not take more than three doses (36 mg) of tizanidine in a 24-hour period. Too much of tizanidine can damage your liver. Cold or allergy medicine, narcotic pain medicine, sleeping pills, other muscle relaxers, and medicine for seizures, depression or anxiety can add to sleepiness caused by tizanidine. Tell your doctor if you need to use any of these other medicines together with tizanidine. Avoid drinking alcohol. It can increase some of the side effects of tizanidine.

What should I discuss with my healthcare provider before taking tizanidine?

Do not use this medication if you are allergic to tizanidine, or if you are also taking the antidepressant fluvoxamine (Luvox), or the antibiotic ciprofloxacin (Cipro).

Before using tizanidine, tell your doctor if you are allergic to any drugs, or if you have:

high or low blood pressure; or

a history of "Long QT syndrome."

If you have any of these conditions, you may not be able to use tizanidine, or you may need a dosage adjustment or special tests during treatment.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether tizanidine passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. In older adults, tizanidine may take much longer to clear from the body. Follow your doctor's instructions about your specific dosage and medication schedule.

How should I take tizanidine?

Take tizanidine exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results from tizanidine.

Take this medication with a full glass of water.

Tizanidine is a short-acting medication, and its effects will be most noticeable between 1 and 6 hours after you take it. This medication should be taken only for daily activities that require relief from muscle spasticity.

In most cases, you may take up to three doses in one day if needed. Allow 6 to 8 hours to pass between doses.

Carefully follow your doctor's instructions about taking this medication with or without food. Taking tizanidine tablets with food can increase the levels of tizanidine in your blood stream, but taking tizanidine capsules with food can decrease the levels.

Switching between tizanidine tablets and capsules, or changing the way you take it with regard to eating, can cause an increase in side effects or a decrease in therapeutic effect. Follow your doctor's instructions carefully. After making any changes in how you take tizanidine, contact your doctor if you notice any change in how well the medicine works or if it causes increased side effects.

Do not take more than three doses (36 mg) in a 24-hour period. Too much of this medication can damage your liver.

To be sure tizanidine is not causing harmful effects, your liver function will need to be tested on a regular basis. Do not miss any scheduled visits to your doctor.

You may have withdrawal symptoms such as dizziness, fast heart rate, tremors, anxiety, and increased spasticity when you stop using tizanidine after using it over a long period of time. Do not stop using this medication suddenly without first talking to your doctor. You may need to use less and less before you stop the medication completely.

Store tizanidine at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include drowsiness, confusion, slow heart rate, shallow breathing, feeling light-headed, fainting, or coma.

What should I avoid?

Tizanidine can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Dizziness is most likely to occur when you rise from a sitting or lying position. Get up slowly to prevent dizziness and a possible fall. Do not use tizanidine at a time when muscle tone is needed to assure safe balance and movement for certain activities. In some situations, it may endanger your physical safety to be in a state of reduced muscle tone. Cold or allergy medicine, narcotic pain medicine, sleeping pills, other muscle relaxers, and medicine for seizures, depression or anxiety can add to sleepiness caused by tizanidine. Tell your doctor if you need to use any of these other medicines together with tizanidine. Avoid drinking alcohol. It can increase some of the side effects of tizanidine.

Tizanidine side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:

feeling light-headed, fainting, slow heart rate;

hallucinations, confusion, unusual thoughts or behavior;

nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or

burning or pain when you urinate.

Less serious tizanidine side effects may be more likely to occur, such as:

drowsiness or dizziness;

feeling anxious or nervous;

sweating or skin rash.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Tizanidine dosing information

Usual Adult Dose for Muscle Spasm:

The initial dosage of tizanidine recommended for this patient with increased muscle tone associated with spasticity related to multiple sclerosis or spinal cord injury is 4 mg orally once a day.

The dose of tizanidine may be repeated as needed at 6 to 8 hour intervals to a maximum dose 3 doses per 24 hours. The dose may be gradually increased (every 4 to 7 days) in increments of 1 to 2 mg until desired response is attained. The manufacturer recommends that total daily dose should not exceed 36 mg. Additionally. the use of single doses greater than 12 mg is not recommended.

Starting at a lower dose and titrating upward minimizes the risk for adverse effects. Experience with single doses greater than 8 mg and total daily dose greater than 24 mg is limited.

Effects appear to be dose related and gradually diminish within 3 to 6 hours after a dose. Use must be individualized and directed at times and activities where benefit is most important.

Usual Geriatric Dose for Muscle Spasm:

In geriatric patients, a starting dose of 2 mg orally once a day may be appropriate.

What other drugs will affect tizanidine?

Before taking tizanidine, tell your doctor if you are using any of the following drugs:

birth control pills;

antibiotics such as enoxacin (Penetrex), gatifloxacin (Tequin), levofloxacin (Levaquin), lomefloxacin (Maxaquin), moxifloxacin (Avelox), ofloxacin (Floxin), sparfloxacin (Zagam), trovafloxacin (Trovan), or norfloxacin (Noroxin);

blood pressure medications such as clonidine (Catapres), guanabenz (Wytensin), guanfacine (Tenex), or methyldopa (Aldomet); or

heart rhythm medications such as amiodarone (Cordarone, Pacerone), mexiletine (Mexitil), propafenone (Rhythmol), and verapamil (Calan, Covera, Isoptin).

This list is not complete and there may be other drugs that can interact with tizanidine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

More about tizanidine

Consumer resources

Professional resources

Related treatment guides

Where can I get more information?

Your pharmacist can provide more information about tizanidine.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use tizanidine only for the indication prescribed.

Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2016 Cerner Multum, Inc. Version: 2.05. Revision Date: 4/12/2009 4:42:37 PM.

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Denver, Co Concrete Contractor, Glez

V. GLEZ. Concrete Contractors L. L.C.

Concrete Contractor in Denver, CO

For premium-quality concrete services in Denver and the surrounding areas, choose V. GLEZ. Concrete Contractors as your partner. We're local to this community, and our owner and lead contractor, Victor Gonzalez, has been providing great service for more than 20 years. If you're searching for a reliable concrete contractor with advanced skills, you have no need to look any further.

Our contractor and crew are appreciated for providing a broad array of concrete masonry services in a quick and professional manner. Some of the jobs we regularly perform include:

Patio installation

Concrete flooring

Concrete driveway repair

Walkway paving

If you need a solid foundation for your new home or business, V. GLEZ. Concrete Contractors is a wise choice. We'll show up on time for your appointment and lay the foundation for your new life with speed and proficiency. We can break up your old concrete and haul it away and deliver and spread pea gravel, and we've even constructed streets and parking lots throughout Thornton, CO. Contact our office to schedule service with our concrete contractor today.

SERVICES

Commercial Concrete Services

Concrete elements play critical roles in and around commercial facilities. And V. GLEZ. Concrete Contractors L. L.C. is your source for expert commercial concrete service in Denver, CO.

Are you looking to add a new deck to your home or commercial facility? Though many people opt to build their decks using wood or newer composite materials, there are many reasons to consider concrete. Concrete is durable and easy to care for. And at V. GLEZ. Concrete Contractors L. L.C. we build and install concrete decks for commercial and residential customers alike throughout Denver, CO.

Concrete Driveway Repair

Even the most well-constructed concrete driveways are likely to succumb to wear and tear over time. If your concrete driveway needs some attention, our team is at your service. At V. GLEZ. Concrete Contractors L. L.C. we offer reliable concrete driveway repair services in Denver, CO. No matter the extent of the damage, we have the tools and skills to get your driveway looking and functioning its best.

Because concrete is so versatile, durable, and easy to maintain, it's a natural choice for residential and commercial driveways. A concrete driveway indicates quality construction from the first glance at your property's exterior. And at V. GLEZ. Concrete Contractors L. L.C. we pride ourselves on offering high-quality concrete driveways for property owners throughout Denver, CO.

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Niszol; Capsule, Neiss Labs Ltd, Niszol

Niszol - Capsule, Neiss Labs Ltd

If you are Pharmaceutical manufacturer. contract manufacturer, machine manufacturer. bulk drug manufacturer or provide facility like pharmaceutical product printing. packaging and consulting then dawabazar. in is a perfect place to promote your business with your brand/products/services.

Create profile and manage brand/products/services for free and get listed in various search

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Create profile and manage products for free and get listed in various search

If you are pharmaceutical retailer or chemist then this place for you to increase your sales and get medicine enquiry from common person. You can find pharmaceutical dealers and stockiest list according to your city for any pharmaceutical company and its product.

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Dawabazar. in is a free content encyclopedia especially for pharmaceutical field. This website provides information about all manufacturing. marketing companies and their products, its compositions along with its dealers. retailers in India. This website also provides many findings on medicines, Pharma companies, Pharma dealers, Pharma retailers, active pharmaceutical ingredients, therapeutic index and pharmacological index which is useful for doctors. medical students and common person.

Fentanyl - Side Effects, Dosage, Interactions, Phentinil

Fentanyl

Fentanyl is the generic form of the brand-name drug Duragesic, a prescription opioid (narcotic) drug used to treat chronic, "around-the-clock" pain.

It should be used only by people who are "opioid-tolerant," or who are already taking opioid pain medications, such as morphine and oxycodone. regularly.

Fentanyl is in a class of drugs called opioid analgesics. which work by binding to nervous system proteins called opioid receptors, thereby blocking the transmission of pain signals to the brain.

Duragesic is a transdermal (through the skin) patch.

Fentanyl is also sold as a lozenge under the brand name Actiq, a tablet that goes under the tongue (Abstral), a film that's applied to the inner lining of the cheek or lip (Onsolis), a tablet that goes between the gum and cheek (Fentora) a nasal spray (Lazanda), a sublingual tablet (Abstral), and a sublingual spray (Subsys).

The Food and Drug Administration (FDA) first approved fentanyl, which is produced by Johnson & Johnson, in 1968.

Over the years, Johnson & Johnson has issued several recalls of its Duragesic pain-relief skin patches.

In 2004 and 2008, the company recalled some of its patches because of damage that could have caused the medication to leak potentially fatal fentanyl gel.

In 2012, Johnson & Johnson recalled more than 53,000 Duragesic patches after fentanyl crystals were found in a patch (the drug is supposed to be completely dissolved).

Fentanyl Abuse

Fentanyl use can lead to addiction, abuse, and misuse, even at the recommended doses — this risk is higher for people with a personal or family history of substance abuse or mental illness.

Fentanyl is almost 100 times more potent than morphine, but the drug is designed to deliver small amounts of fentanyl each hour over an extended period of time.

When ingested, however, the Duragesic patch can deliver its entire dose all at once, increasing the risk of an overdose.

In 2008, a study in the Journal of Forensic Sciences reviewed seven case reports of oral abuse of Duragesic and found that fentanyl overdose caused or contributed to the deaths of the persons in each case.

Fentanyl Withdrawal

As with other addictive drugs, stopping fentanyl suddenly may result in withdrawal symptoms, including:

Restlessness, yawning, and difficulty falling asleep or staying asleep

Teary eyes and runny nose

Sweating and chills

Muscle, joint, and back pain

Enlarged pupils

Irritability and anxiety

Weakness

Stomach cramps, nausea, loss of appetite, vomiting, and diarrhea

Fast heartbeat and rapid breathing

Fentanyl Warnings

Fentanyl carries a black-box warning about its potential for addiction, abuse, misuse, and its associated risk of fatal overdose.

People who are accidentally exposed to fentanyl, particularly children, are especially vulnerable to a fatal overdose.

Fentanyl should be used only by people with chronic pain who are opioid tolerant.

You should not use it to treat mild, post-operative, intermittent, or short-term pain.

People with significant respiratory problems, acute or severe asthma, paralytic ileus (an obstruction of the intestine), or a known sensitivity to fentanyl shouldn't take fentanyl.

People who are non-opioid tolerant shouldn't take fentanyl, because the drug carries a high risk of life-threatening respiratory depression (low breathing rate).

Respiratory depression may also occur in opioid-tolerant people, even when the drug is used as directed, especially when first going on fentanyl or increasing the dosage.

If you're older, debilitated, or have a wasting syndrome called cachexia, you're more likely to experience respiratory depression.

Potentially fatal respiratory depression may also occur if you use fentanyl while taking cytochrome P450 3A4 (CYP3A4) inhibitors, such as ritonavir (Norvir), nefazodone (Serzone), nelfinavir (Viracept), and after consuming grapefruit or grapefruit juice.

Using fentanyl while taking central nervous system depressants, such as sedatives, hypnotics, alcohol, and other opioids, can cause abnormally low blood pressure, profound sedation, coma, respiratory depression, and death.

When using fentanyl, don't expose the patch or surrounding area to direct external heat sources such as saunas, hot tubs, and heating pads, as this may increase your body's rate of fentanyl absorption, possibly leading to a fatal overdose.

You're also at risk for increased fentanyl exposure if you have a fever or an increased core body temperature, such as from strenuous exercise.

Pregnancy and Fentanyl

Prolonged use of opioid analgesics (painkillers), including fentanyl, during pregnancy can produce drug dependence in newborns.

It can also result in neonatal opioid withdrawal syndrome, which has various symptoms and signs, including:

Poor feeding and irritability

Diarrhea

Tremor and seizures

Rigidity

Animal pregnancy studies have shown that fentanyl can have an "adverse" effect on the fetus, and so there's a possibility the opioid may harm developing human fetuses.

It should only be used during pregnancy if the potential pain-relieving benefits outweigh the potential risks to the fetus.

Fentanyl shouldn't be used during or immediately before labor because opioids can cross the placenta and potentially cause respiratory depression in newborns. The drug may also prolong labor.

Because fentanyl is excreted in breast milk, do not use fentanyl if you're breastfeeding.

Fentanyl FAQ

Q: I was prescribed fentanyl patch (25) for excruciating back pain, but after reading all of the side effects from the included pamphlet, I am actually afraid to use it. The first thing that struck me was that it can cause "fatal breathing problems." It also went on to say that it is more addicting than morphine, and if you have heart disease and hypothyroidism (of which I have both), I should not use it. Please give me some ideas on whether or not I should use the fentanyl patch (25).

A: The problems that you noted are in the literature. I would discuss this more with your health care provider for peace of mind before trying the patch. I would ask him if there is any other type of medication that you could use to help with the pain. Be sure to bring the pamphlet with you which contains this information.

Q: My doctor put me on fentanyl patches 25 mcg. I have been on Lortab 10mg for many years which I tolerate well. I've only been on the patch 72 hours but I feel tired. Will I adapt to this medicine and get over this feeling? I am a 65 year old male who likes to stay active despite my pain and do not like this feeling!

A: Fentanyl (Duragesic) skin patches are used to relieve moderate to severe pain that is expected to last for some time, that does not go away, and that cannot be treated with other pain medications. Fentanyl skin patches are only used to treat people who are tolerant (used to the effects of the medication) to narcotic pain medications. Fentanyl is in a class of medications called opiate (narcotic) analgesics. It works by changing the way the brain and nervous system respond to pain. Side effects of Fentanyl include headache, dizziness, confusion, weakness, drowsiness and constipation. If you take Fentanyl on a regular basis, these effects usually wear off 1-2 weeks after you start taking the medication or increase your dose. For more information on Fentanyl see http://www. everydayhealth. com/drugs/fentanyl Lori Poulin, PharmD

Q: I have pain, and my doctor prescribed fentanyl patches 25 mcg. I've been on lortab 10 mg for many years, which I tolerate well. I've only been on the patch 72 hours, but i feel tired. I like to stay active despite my pain. Will I adapt to this medicine and get through this feeling?

A: Fentanyl (Duragesic) skin patches are used to relieve moderate to severe pain that is expected to last for some time, that does not go away, and that cannot be treated with other pain medications. Fentanyl skin patches are only used to treat people who are tolerant (used to the effects of the medication) to narcotic pain medications. Fentanyl is in a class of medications called opiate (narcotic) analgesics. It works by changing the way the brain and nervous system respond to pain. Side effects of fentanyl include headache, dizziness, confusion, weakness, drowsiness and constipation. If you take fentanyl on a regular basis, these effects usually wear off 1-2 weeks after you start taking the medication or increase your dose. You may also find helpful information on fentanyl at http://www. everydayhealth. com/drugs/fentanyl Lori, PharmD

Q: Can the Duragesic patch cause intestinal obstruction?

A: The Duragesic skin patch contains fentanyl, a narcotic (or opioid) for the treatment of moderate to severe chronic pain. As with all narcotic pain relievers, fentanyl can be habit-forming and should only be used by the person for whom it was prescribed. According to the package insert, the most significant side effect is the potential for respiratory depression, which can lead to weak and shallow breathing. If this occurs, the patch should be removed and you should contact your doctor. The most common side effects include nausea, vomiting, stomach pain, constipation, gas, dizziness, drowsiness, anxiety, sleep problems (insomnia), muscle stiffness, back pain, itching, blistering, redness, or swelling where the patch was worn, and increased sweating or urinating. Because Duragesic can cause significant drowsiness, it is important to understand how the medication affects you before driving or operating machinery or performing other tasks that require mental alertness. All narcotic pain relievers can cause constipation because of their effects on gastrointestinal motility and secretions. Many patients require a bowel regimen consisting of a stool softener and mild stimulant throughout therapy with narcotic pain relieves. If you do not have a bowel movement for three days, an enema or suppository should be administered to prevent impaction. For more information, please consult your health care provider and visit http://www. everydayhealth. com/drugs/duragesic-12. Michelle McDermott, PharmD

Q: How should fentanyl patches be administered?

A: Fentanyl skin patches are used in the treatment of persistent moderate to severe chronic pain. Fentanyl is an opioid analgesic, or pain killer. It works by changing the way the brain and nervous system respond to pain. Fentanyl patches are only for people whose pain cannot be controlled by other pain medications including oral opioids. Fentanyl patches are only indicated to be used in people who are already receiving opioid pain medications. Fentanyl patches are used for pain relief that is needed around the clock, not on an as needed basis. Fentanyl patches can be habit forming. Some of the common side effects associated with fentanyl patches include confusion, headache, drowsiness, dizziness, slowed breathing and heart rate, constipation and dehydration. Here are some suggestions for applying the fentanyl patch according to the prescribing information. A· The patch should be applied to flat, non-irritated skin -- like the back, flank, chest or upper arm A· If there is hair on the area, remove by clipping, not shaving A· If the skin needs to be cleaned prior to application, use clear water A· Do not use lotions, oils, soaps, or alcohol on the skin that may irritate it or change its characteristics A· Allow the skin to dry completely before applying the patch A· Use the palm of the hand to press and hold down the patch on the skin for 30 seconds, making sure contact is complete, especially around the edges If there is a problem with the patch adhering to the skin, a transparent adhesive film dressing, like Bioclusive or Askina Derm, may be placed over the patch. This may not be a complete list of side effects or directions for patch application. It is important to speak with your health care provider in regards to appropriate dosing and application of the fentanyl patch, and follow the complete directions provided with your prescription. Kristen Dore, PharmD

Q: How long does fentanyl stay in the body?

A: Fentanyl is a potent pain relieving medication delivered topically through a skin patch. According to the prescribing literature, once the Fentanyl patch is removed, the concentration of Fentanyl in the blood stream is reduced gradually. It can take approximately 20 to 27 hours for the blood concentration of Fentanyl patch to be decreased by 50% once the patch is removed. Therefore, it could possibly take 48 to 72 hours for the body to completely eliminate Fentanyl from the blood stream. The breakdown of medications is dependent on kidney function, liver function, other medications, age, medical conditions, health status, the use of herbal products and other nonprescription products. The manufacturer recommends that a patient discontinuing the patch should be monitored for at least 24 hours following the removal of the patch for any adverse effects. Consuelo Worley, RPh, MS

Q: How do you stop taking a fentanyl patch?

A: Fentanyl (Duragesic) is classified as an opioid analgesic medication. Fentanyl is approved for the treatment of persistent, moderate to severe pain that requires continuous, around-the-clock opioid administration for a prolonged period of time and for pain that can't be controlled with other medications such as nonsteroidal anti-inflammatory medications, opioid combination medications or immediate-release opioids. If you feel that you should not be using fentanyl patches any longer, it is important that you talk to your physician. You should not stop the medication or decrease the dose of the medication without first talking to your physician. According to the prescribing information for fentanyl, if the medication is to be stopped, your physician may prescribe a tapering down of your fentanyl dose. Abruptly discontinuing the medication can result in withdrawal symptoms. There are specific directions and charts that your physician can utilize to convert a patient to different pain medications if this is required. Tapering of dosages and converting patients to different pain medications is done at the discretion of your physician. Your physician can provide you specific directions on how to stop taking fentanyl patches, if this is an appropriate therapeutic decision. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Jen Marsico, RPh

By Joseph Bennington-Castro | Medically Reviewed by Sanjai Sinha, MD

Latest Update: 2015-01-09 Copyright © 2014 Everyday Health Media, LLC

Azithromycin Medlineplus Drug Information, Althromicin

Azithromycin

Azithromycin is used to treat certain bacterial infections, such as bronchitis; pneumonia; sexually transmitted diseases (STD); and infections of the ears, lungs, sinuses, skin, throat, and reproductive organs. Azithromycin also is used to treat or prevent disseminated Mycobacterium avium complex (MAC) infection [a type of lung infection that often affects people with human immunodeficiency virus (HIV)]. Azithromycin is in a class of medications called macrolide antibiotics. It works by stopping the growth of bacteria. Antibiotics will not kill viruses that can cause colds, flu, or other infections.

How should this medicine be used?

Azithromycin comes as a tablet, an extended-release (long-acting) suspension (liquid) and a suspension (liquid) to take by mouth. The tablets and suspension (Zithromax) are usually taken with or without food once a day for 1 to 5 days. When used for the prevention of disseminated MAC infection, azithromycin tablets are usually taken with or without food once weekly. The extended-release suspension (Zmax) is usually taken on an empty stomach (at least 1 hour before or 2 hours after a meal) as a one-time dose. To help you remember to take azithromycin, take it around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take azithromycin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Shake the liquid well before each use to mix the medication evenly. Use a dosing spoon, oral syringe, or measuring cup to measure the correct amount of medication. Rinse the measuring device with water after taking the full dose of medication.

If you receive azithromycin powder for suspension in the single-dose, 1-gram packet, you must first mix it with water before you take the medication. Mix the contents of the 1-gram packet with 1/4 cup (60 mL) of water in a glass and consume the entire contents immediately. Add an additional 1/4 cup (60 mL) of water to the same glass, mix, and consume the entire contents to ensure that you receive the entire dose.

If you receive azithromycin extended-release suspension as a dry powder you must first add water to the bottle before you take the medication. Open the bottle by pressing down on the cap and twisting. Measure 1/4 cup (60 mL) of water and add to the bottle. Close the bottle tightly and shake well to mix.

Use the extended-release liquid within 12 hours of receiving it from the pharmacy or adding water to the powder.

If you vomit within an hour after taking azithromycin, call your doctor right away. Your doctor will tell you if you need to take another dose. Do not take another dose unless your doctor tells you to do so.

You should begin to feel better during the first few days of treatment with azithromycin. If your symptoms do not improve, or get worse, call your doctor.

Take azithromycin until you finish the prescription, even if you feel better. Do not stop taking azithromycin unless you experience the severe side effects described in the SIDE EFFECTS section. If you stop taking azithromycin too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

Other uses for this medicine

Azithromycin is also used sometimes to treat H. pylori infection, travelers' diarrhea, and other gastrointestinal infections; Legionnaires' disease (a type of lung infection); pertussis (whooping cough; a serious infection that can cause severe coughing); and babesiosis (an infectious disease carried by ticks). It is also used to prevent heart infection in people having dental or other procedures, and to prevent STD in victims of sexual assault. Talk to your doctor about the possible risks of using this medication for your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking azithromycin,

tell your doctor and pharmacist if you are allergic to azithromycin, clarithromycin (Biaxin, in Prevpac), dirithromycin (not available in the U. S.), erythromycin (E. E.S. E-Mycin, Erythrocin), telithromycin (Ketek), any other medications, or any of the ingredients in azithromycin tablets or suspension (liquid). Ask your pharmacist for a list of the ingredients.

tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); cyclosporine (Neoral, Sandimmune); digoxin (Lanoxin); dihydroergotamine (D. H.E. 45, Migranal); ergotamine (Ergomar); medications for irregular heartbeat such as amiodarone (Cordarone, Pacerone), dofetilide (Tikosyn), procainamide (Procanbid), quinidine, and sotalol (Betapace, Sorine); nelfinavir (Viracept); phenytoin (Dilantin); and terfenadine (not available in the U. S.). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

if you are taking antacids containing aluminum hydroxide or magnesium hydroxide (Maalox, Mylanta, Tums, others), you will need to allow some time to pass between when you take a dose of these antacids and when you take a dose of azithromycin tablets or liquid. Ask your doctor or pharmacist how many hours before or after you take azithromycin you may take these medications. The extended-release suspension may be taken at any time with antacids.

tell your doctor if you have ever had jaundice (yellowing of the skin or eyes) or other liver problems while taking azithromycin. Your doctor will probably tell you not to take azithromycin.

tell your doctor if you or anyone in your family has or has ever had a prolonged QT interval (a rare heart problem that may cause irregular heartbeat, fainting, or sudden death) or a fast, slow, or irregular heartbeat, and if you have low levels of magnesium or potassium in your blood; if you have a blood infection; heart failure; cystic fibrosis; AIDS or human immunodeficiency virus (HIV) infection; myasthenia gravis (a condition of muscles and the nerves that control them); or if you have kidney or liver disease.

tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking azithromycin, call your doctor.

What special dietary instructions should I follow?

Azithromycin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

Some side effects can be serious. If you experience any of these symptoms, stop taking azithromycin and call your doctor immediately or get emergency medical treatment:

fast, pounding, or irregular heart beat

dizziness

fainting

rash

hives

itching

wheezing or difficulty breathing or swallowing

swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs

hoarseness

mouth sores

severe diarrhea (watery or bloody stools) that may occur with or without fever and stomach cramps (may occur up to 2 months or more after your treatment)

yellowing of the skin or eyes

extreme tiredness

unusual bleeding or bruising

lack of energy

loss of appetite

pain in the upper right part of the stomach

flu-like symptoms

dark-colored urine

blisters or peeling of the skin

unusual muscle weakness or difficulty with muscle control

Azithromycin may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www. fda. gov/Safety/MedWatch ) or by phone (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store azithromycin tablets and suspension at room temperature and away from excess heat and moisture (not in the bathroom). Do not refrigerate or freeze the suspension. Throw away any azithromycin suspension that is left over after 10 days and any medication that is outdated or no longer needed. Throw away any unused extended-release azithromycin suspension after dosing is complete. Talk to your pharmacist about the proper disposal of your medication.

In case of emergency/overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Aloprim - Fda Prescribing Information, Side Effects And Uses, Aloprol

Aloprim

Aloprim (allopurinol sodium) for Injection is the brand name for allopurinol, a xanthine oxidase inhibitor. Aloprim (allopurinol sodium) for Injection is a sterile solution for intravenous infusion only. It is available in vials as the sterile lyophilized sodium salt of allopurinol equivalent to 500 mg of allopurinol. Aloprim (allopurinol sodium) for Injection contains no preservatives.

The chemical name for allopurinol sodium is 1,5-dihydro-4 H - pyrazolo[3,4- d ]pyrimidin-4-one monosodium salt. It is a white amorphous mass with a molecular weight of 158.09 and molecular formula C 5 H 3 N 4 NaO. The structural formula is:

The pKa of allopurinol sodium is 9.31.

Aloprim - Clinical Pharmacology

Allopurinol acts on purine catabolism without disrupting the biosynthesis of purines. It reduces the production of uric acid by inhibiting the biochemical reactions immediately preceding its formation. The degree of this decrease is dose dependent.

Allopurinol is a structural analogue of the natural purine base, hypoxanthine. It is an inhibitor of xanthine oxidase, the enzyme responsible for the conversion of hypoxanthine to xanthine and of xanthine to uric acid, the end product of purine metabolism in man. Allopurinol is metabolized to the corresponding xanthine analogue, oxypurinol (alloxanthine), which also is an inhibitor of xanthine oxidase.

Reutilization of both hypoxanthine and xanthine for nucleotide and nucleic acid synthesis is markedly enhanced when their oxidations are inhibited by allopurinol and oxypurinol. This reutilization does not disrupt normal nucleic acid anabolism, however, because feedback inhibition is an integral part of purine biosynthesis. As a result of xanthine oxidase inhibition, the serum concentration of hypoxanthine plus xanthine in patients receiving allopurinol for treatment of hyperuricemia is usually in the range of 0.3 to 0.4 mg/dL compared to a normal level of approximately 0.15 mg/dL. A maximum of 0.9 mg/dL of these oxypurines has been reported when the serum urate was lowered to less than 2 mg/dL by high doses of allopurinol. These values are far below the saturation levels, at which point their precipitation would be expected to occur (above 7 mg/dL).

The renal clearance of hypoxanthine and xanthine is at least 10 times greater than that of uric acid. The increased xanthine and hypoxanthine in the urine have not been accompanied by problems of nephrolithiasis. There are isolated case reports of xanthine crystalluria in patients who were treated with oral allopurinol.

The action of oral allopurinol differs from that of uricosuric agents, which lower the serum uric acid level by increasing urinary excretion of uric acid. Allopurinol reduces both the serum and urinary uric acid levels by inhibiting the formation of uric acid. The use of allopurinol to block the formation of urates avoids the hazard of increased renal excretion of uric acid posed by uricosuric drugs.

PHARMACOKINETICS

Following intravenous administration in six healthy male and female subjects, allopurinol was rapidly eliminated from the systemic circulation primarily via oxidative metabolism to oxypurinol, with no detectable plasma concentration of allopurinol after 5 hours post dosing. Approximately 12% of the allopurinol intravenous dose was excreted unchanged, 76% excreted as oxypurinol, and the remaining dose excreted as riboside conjugates in the urine. The rapid conversion of allopurinol to oxypurinol was not significantly different after repeated allopurinol dosing. Oxypurinol was present in systemic circulation in much higher concentrations and for a much longer period than allopurinol; thus, it is generally believed that the pharmacological action of allopurinol is mediated via oxypurinol. Oxypurinol was primarily eliminated unchanged in urine by glomerular filtration and tubular reabsorption, with a net renal clearance of about 30 mL/min.

To compare the pharmacokinetics of allopurinol and oxypurinol between intravenous (i. v.) and oral (p. o.) administration of Aloprim (allopurinol sodium) for Injection, a well-controlled, four-way crossover study was conducted in 16 male healthy volunteers. Aloprim (allopurinol sodium) for Injection was administered via an intravenous infusion over 30 minutes. Pharmacokinetic parameter estimates of allopurinol (mean ± S. D.) following single i. v. and p. o. administration of Aloprim (allopurinol sodium) for Injection are summarized as follows:

Administration of Aloprim ® (allopurinol sodium) for Injection

In general, the ratio of the area under the plasma concentration vs time curve (AUC 0->∞ ) between oxypurinol and allopurinol was in the magnitude of 30 to 40. The C max and AUC 0->∞ for both allopurinol and oxypurinol following i. v. administration of Aloprim (allopurinol sodium) for Injection were dose proportional in the dose range of 100 to 300 mg. The half-life of allopurinol and oxypurinol was not influenced by the route of Aloprim (allopurinol sodium) for Injection administration. Oral and intravenous administration of Aloprim (allopurinol sodium) for Injection at equal doses produced nearly superimposable oxypurinol plasma concentration vs time profiles, and the relative bioavailability of oxypurinol (F relative ) was approximately 100%. Thus, the pharmacokinetics and plasma profiles of oxypurinol, the major pharmacological component derived from allopurinol, are similar after intravenous and oral administration of Aloprim (allopurinol sodium) for Injection.

A compassionate plea trial was conducted from 1977 through 1989 in which 718 evaluable patients with malignancies requiring treatment with cytotoxic chemotherapy, but who were unable to ingest or retain oral medication, received i. v. Aloprim (allopurinol sodium) for Injection in the U. S. Of these patients, 411 had established hyperuricemia and 307 had normal serum urate levels at the time that treatment was initiated. Normal serum uric acid levels were achieved in 68% (reduction of serum uric acid was documented in 93%) of the former, and were maintained throughout chemotherapy in 97% of the latter. Because of the study design, it was not possible to assess the impact of the treatment upon the clinical outcome of the patient groups.

Indications and Usage for Aloprim

Aloprim (allopurinol sodium) for Injection is indicated for the management of patients with leukemia, lymphoma, and solid tumor malignancies who are receiving cancer therapy which causes elevations of serum and urinary uric acid levels and who cannot tolerate oral therapy.

Contraindications

Patients who have developed a severe reaction to allopurinol should not be restarted on the drug.

Warnings

ALLOPURINOL SHOULD BE DISCONTINUED AT THE FIRST APPEARANCE OF SKIN RASH OR OTHER SIGNS WHICH MAY INDICATE AN ALLERGIC REACTION. In some instances with oral allopurinol, a skin rash may be followed by more severe hypersensitivity reactions such as exfoliative, urticarial, and purpuric lesions as well as Stevens-Johnson syndrome (erythema multiforme exudativum), and/or generalized vasculitis, irreversible hepatotoxicity and, on rare occasions, death.

In patients receiving mercaptopurine or azathioprine, the concomitant administration of 300 to 600 mg of Aloprim (allopurinol sodium) for Injection per day will require a reduction in dose to approximately one-third to one-fourth of the usual dose of mercaptopurine or azathioprine. Subsequent adjustment of doses of mercaptopurine or azathioprine should be made on the basis of therapeutic response and the appearance of toxic effects (see PRECAUTIONS: Drug Interactions ).

A few cases of reversible clinical hepatotoxicity have been noted in patients taking oral allopurinol, and in some patients asymptomatic rises in serum alkaline phosphatase or serum transaminase have been observed. If anorexia, weight loss, or pruritus develop in patients on allopurinol, evaluation of liver function should be part of their diagnostic workup. In patients with pre-existing liver disease, periodic liver function tests are recommended during the early stages of therapy.

Due to the occasional occurrence of drowsiness, patients should be alerted to the need for due precaution when engaging in activities where alertness is mandatory.

The occurrence of hypersensitivity reactions to allopurinol may be increased in patients with decreased renal function receiving thiazides and allopurinol concurrently. Thus, in patients with decreased renal function, such combinations should be administered with caution.

Precautions

General

A fluid intake sufficient to yield a daily urinary output of at least two liters in adults and the maintenance of a neutral or, preferably, slightly alkaline urine are desirable to (1) avoid the theoretical possibility of formation of xanthine calculi under the influence of allopurinol therapy and (2) help prevent renal precipitation of urates in patients receiving concomitant uricosuric agents.

A few patients with pre-existing renal disease or poor urate clearance have shown a rise in BUN during allopurinol administration, although a decrease in BUN has also been observed. In patients with hyperuricemia due to malignancy, the vast majority of changes in renal function are attributable to the underlying malignancy rather than to therapy with allopurinol. Concurrent conditions such as multiple myeloma and congestive myocardial disease were present among those patients whose renal function deteriorated after allopurinol was begun. Renal failure is rarely associated with hypersensitivity reactions to allopurinol.

Patients with decreased renal function do require lower doses of allopurinol. Patients should be carefully observed during the early stages of allopurinol administration so that the dosage can be appropriately adjusted for renal function.

In patients with severely impaired renal function or decreased urate clearance, the half-life of oxypurinol in the plasma is greatly prolonged. Patients should be treated with the lowest effective dose, in order to minimize possible side effects. The appropriate dose of Aloprim (allopurinol sodium) for Injection for patients with a creatinine clearance ≤10 mL/min is 100 mg per day. For patients with a creatinine clearance between 10 and 20 mL/min, a dose of 200 mg per day is recommended. With extreme renal impairment (creatinine clearance less than 3 mL/min), the interval between doses may also need to be extended.

Bone marrow suppression has been reported in patients receiving allopurinol; however, most of these patients were receiving concomitant medications with the known potential to cause such an effect. The suppression has occurred from as early as 6 weeks to as long as 6 years after the initiation of allopurinol therapy.

Laboratory Tests

The correct dosage and schedule for maintaining the serum uric acid within the normal range is best determined by using the serum uric acid as an index.

In patients with pre-existing liver disease, periodic liver function tests are recommended during the early stages of therapy (see WARNINGS ).

Allopurinol and its primary active metabolite, oxypurinol, are eliminated by the kidneys; therefore, changes in renal function have a profound effect on dosage. In patients with decreased renal function, or who have concurrent illnesses which can affect renal function such as hypertension and diabetes mellitus, periodic laboratory parameters of renal function, particularly BUN and serum creatinine or creatinine clearance, should be performed and the patient's allopurinol dosage reassessed.

The prothrombin time should be reassessed periodically in the patients receiving dicumarol who are given allopurinol.

Drug Interactions

The following drug interactions were observed in some patients undergoing treatment with oral allopurinol. Although the pattern of use for oral allopurinol includes longer term therapy, particularly for gout and renal calculi, the experience gained may be relevant.

Allopurinol inhibits the enzymatic oxidation of mercaptopurine and azathioprine to 6-thiouric acid. This oxidation, which is catalyzed by xanthine oxidase, inactivates mercaptopurine. Therefore, the concomitant administration of 300 to 600 mg of oral allopurinol per day will require a reduction in dose to approximately one-third to one-fourth of the usual dose of mercaptopurine or azathioprine. Subsequent adjustment of doses of mercaptopurine or azathioprine should be made on the basis of therapeutic response and the appearance of toxic effects.

It has been reported that allopurinol prolongs the half-life of the anticoagulant, dicumarol. Consequently, prothrombin time should be reassessed periodically in patients receiving both drugs. The clinical basis of this drug interaction has not been established.

Since the excretion of oxypurinol is similar to that of urate, uricosuric agents, which increase the excretion of urate, are also likely to increase the excretion of oxypurinol. As a result, the concomitant administration of uricosuric agents decreases the inhibition of xanthine oxidase by oxypurinol and increases the urinary excretion of uric acid.

Reports that the concomitant administration of allopurinol and thiazide diuretics contributed to increased allopurinol toxicity were reviewed; a causal mechanism or cause-and-effect relationship was not found. Renal function should be monitored in patients on thiazide diuretics and allopurinol (see WARNINGS ).

An increase in the frequency of skin rash has been reported among patients receiving ampicillin or amoxicillin concurrently with allopurinol compared to patients who are not receiving both drugs. The cause of this reaction has not been established.

Enhanced bone marrow suppression by cyclophosphamide and other cytotoxic agents has been reported among patients with neoplastic disease, except leukemia, in the presence of allopurinol. However, in a well-controlled study of patients with lymphoma on combination therapy, allopurinol did not increase the marrow toxicity of patients treated with cyclophosphamide, doxorubicin, bleomycin, procarbazine, and/or mechlorethamine.

The half-life of chlorpropamide in the plasma may be prolonged by allopurinol, since allopurinol and chlorpropamide may compete for excretion in the renal tubule. The risk of hypoglycemia secondary to this mechanism may be increased if allopurinol and chlorpropamide are given concomitantly in the presence of renal insufficiency.

Reports indicate that cyclosporine levels may be increased during concomitant treatment with Aloprim (allopurinol sodium) for Injection. Monitoring of cyclosporine levels and possible adjustment of cyclosporine dosage should be considered when these drugs are co-administered.

Drug/Laboratory Test Interactions

Allopurinol is not known to alter the accuracy of laboratory tests.

Carcinogenesis, Mutagenesis and Impairment of Fertility

Allopurinol was administered at doses up to 20 mg/kg/day to mice and rats for the majority of their life span. No evidence of carcinogenicity was seen in either mice or rats (at doses about 1/6 or 1/3 the recommended human dose on a mg/m 2 basis, respectively).

Allopurinol administered intravenously to rats (50 mg/kg) was not incorporated into rapidly replicating intestinal DNA. No evidence of clastogenicity was observed in an in vivo micronucleus test in rats, or in lymphocytes taken from patients treated with allopurinol (mean duration of treatment 40 months), or in an in vitro assay with human lymphocytes.

Impairment of Fertility

Allopurinol oral doses of 20 mg/kg/day had no effect on male or female fertility in rats or rabbits (about 1/3 or 1/2 the human dose on a mg/m 2 basis, respectively).

Pregnancy

Pregnancy Category C

There was no evidence of fetotoxicity or teratogenicity in rats or rabbits treated during the period of organogenesis with oral allopurinol at doses up to 200 mg/kg/day and up to 100 mg/kg/day, respectively (about three times the human dose on a mg/m 2 basis). However, there is a published report in pregnant mice that single intraperitoneal doses of 50 or 100 mg/kg (about 1/3 or 3/4 the human dose on a mg/m 2 basis) of allopurinol on gestation days 10 or 13 produced significant increases in fetal deaths and teratogenic effects (cleft palate, harelip, and digital defects). It is uncertain whether these findings represented a fetal effect or an effect secondary to maternal toxicity. There are, however, no adequate or well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Experience with allopurinol during human pregnancy has been limited partly because women of reproductive age rarely require treatment with allopurinol. Two unpublished reports and one published paper describe women giving birth to normal offspring after receiving oral allopurinol during pregnancy. There have been no pregnancies reported in patients receiving Aloprim (allopurinol sodium) for Injection, but it is assumed that the same risks would apply.

Nursing Mothers

Allopurinol and oxypurinol have been found in the milk of a mother who was receiving allopurinol. Since the effect of allopurinol on the nursing infant is unknown, caution should be exercised when allopurinol is administered to a nursing woman.

Pediatric Use

Clinical data are available on approximately 200 pediatric patients treated with Aloprim (allopurinol sodium) for Injection. The efficacy and safety profile observed in this patient population were similar to that observed in adults (see INDICATIONS and DOSAGE AND ADMINISTRATION ).

Geriatric Use

Clinical studies of Aloprim (allopurinol sodium) for Injection did not include sufficient numbers of patients aged 65 and over to determine whether they respond differently than younger patients. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.

Adverse Reactions

In an uncontrolled, compassionate plea protocol, 125 of 1,378 patients reported a total of 301 adverse reactions while receiving Aloprim (allopurinol sodium) for Injection. Most of the patients had advanced malignancies or serious underlying diseases and were taking multiple concomitant medications. Side effects directly attributable to Aloprim (allopurinol sodium) for Injection were reported in 19 patients. Fifteen of these adverse experiences were allergic in nature (rash, eosinophilia, local injection site reaction). One adverse experience of severe diarrhea and one incidence of nausea were also reported as being possibly attributable to Aloprim (allopurinol sodium) for Injection. Two patients had serious adverse experiences (decreased renal function and generalized seizure) reported as being possibly attributable to Aloprim (allopurinol sodium) for Injection.

A listing of the adverse reactions regardless of causality reported from clinical trials follows:

Incidence Greater Than 1%:

The most frequent adverse reaction to oral allopurinol is skin rash. Skin reactions can be severe and sometimes fatal. Therefore, treatment with Aloprim (allopurinol sodium) for Injection should be discontinued immediately if a rash develops (see WARNINGS ). For further details on hypersensitivity reactions to treatment with oral allopurinol, refer to the package insert for allopurinol tablets.

Overdosage

Massive overdosing or acute poisoning by Aloprim (allopurinol sodium) for Injection has not been reported.

In mice, the minimal lethal dose is 45 mg/kg given intravenously or 500 mg/kg orally (about 1/3 or 4 times the usual human dose on a mg/m 2 basis). Hypoactivity was observed with these doses. In rats, the minimum lethal dose is 100 mg/kg i. v. and 5000 mg/kg orally (about 1.5 and 75 times the usual human dose on a mg/m 2 basis).

In the management of overdosage, there is no specific antidote for Aloprim (allopurinol sodium) for Injection. There has been no clinical experience in the management of a patient who has taken massive amounts of allopurinol.

Both allopurinol and oxypurinol are dialyzable; however, the usefulness of hemodialysis or peritoneal dialysis in the management of an overdose of Aloprim (allopurinol sodium) for Injection is unknown.

Aloprim Dosage and Administration

Children and Adults

The dosage of Aloprim (allopurinol sodium) for Injection to lower serum uric acid to normal or near-normal varies with the severity of the disease. The amount and frequency of dosage for maintaining the serum uric acid just within the normal range is best determined by using the serum uric acid level as an index. In adults, in one clinical trial, doses over 600 mg a day did not appear to be more effective. The recommended daily dose of Aloprim (allopurinol sodium) for Injection is as follows:

Recommended Daily Dose

Administration

In both adults and children, the daily dose can be given as single infusion or in equally divided infusions at 6-, 8-, or 12- hour intervals at the recommended final concentration of not greater than 6 mg/mL (see Preparation of Solution ). The rate of infusion depends on the volume of infusate. Whenever possible, therapy with Aloprim (allopurinol sodium) for Injection should be initiated 24 to 48 hours before the start of chemotherapy known to cause tumor cell lysis (including adrenocortical steroids).

Aloprim (allopurinol sodium) for Injection should not be mixed with or administered through the same intravenous port with agents which are incompatible in solution with Aloprim (allopurinol sodium) for Injection (see Preparation of Solution ).

Preparation of Solution

Aloprim (allopurinol sodium) for Injection must be reconstituted and diluted. The contents of each 30 mL vial should be dissolved with 25 mL of Sterile Water for Injection. Reconstitution yields a clear, almost colorless solution with no more than a slight opalescence. This concentrated solution has a pH of 11.1 to 11.8. It should be diluted to the desired concentration with 0.9% Sodium Chloride Injection or 5% Dextrose for Injection. Sodium bicarbonate-containing solutions should not be used. A final concentration of no greater than 6 mg/mL is recommended. The solution should be stored at 20° to 25°C (68° to 77°F) and administration should begin within 10 hours after reconstitution. Do not refrigerate the reconstituted and/or diluted product.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Do not use this product if particulate matter or discoloration is present.

The following table lists drugs that are physically incompatible in solution with Aloprim (allopurinol sodium) for Injection.

Drugs That Are Physically Incompatible in Solution with Aloprim ® (allopurinol sodium) for Injection

How is Aloprim Supplied

STERILE SINGLE-USE VIAL FOR INTRAVENOUS INFUSION.

Aloprim (allopurinol sodium) for Injection, 30 mL flint glass vials with rubber stoppers each containing allopurinol sodium equivalent to 500 mg of allopurinol (white lyophilized powder).

NDC 67457-187-50 carton containing one vial

Store unreconstituted powder at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]

Manufactured for: Mylan Institutional LLC Rockford, IL 61103 U. S.A.

Manufactured by: Patheon Manufacturing Services LLC Greenville, NC 27834

013401 REVISED JUNE 2014 MI:ALOPIJ:R4

Aloprim ® is a registered trademark of Mylan Teoranta.

PRINCIPAL DISPLAY PANEL - 500 mg Label

NDC 67457-187-50 500 mg

Aloprim ® (allopurinol sodium) for Injection 500 mg

equivalent to 500 mg allopurinol

For Intravenous Infusion

Rx only Single-Use Vial

Preparation of Solution: Inject 25 mL Sterile Water for Injection into vial. Swirl vial until solution results. The solution should be stored at 20° to 25°C (68° to 77°F) and administration should begin within 10 hours after reconstitution. Further dilution is required before intravenous administration.

Usual Dosage and Reconstitution Instructions: See accompanying prescribing information.

Store at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]

Aloprim® is a registered trademark of Mylan Teoranta

Manufactured for: Mylan Institutional LLC Rockford, IL 61103 U. S.A.

Anacin - Pain Relief, Algocit

Anacin is a pain reliever intended for the temporary relief of minor aches and pains. Anacin is a combination salicylate and stimulant. It works by blocking several different chemical processes within the body that cause pain, inflammation, and fever. It also reduces the tendency for blood to clot.

Availability: In Stock (17 packs)

Anacin is used for treating pain including, headache, muscle aches, sprains, tooth extraction and toothache, menstrual cramps, arthritis and rheumatism, and pain and fever of the common cold. It may also be used for other conditions as determined by your doctor.

Use Anacin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take Anacin by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation. Taking it with food may not decrease the risk of stomach or bowel problems (eg, bleeding, ulcers) that may occur while taking Anacin.

Take Anacin with a full glass of water (8 oz/240 mL). Do not lie down for 30 minutes after taking Anacin.

Use Anacin exactly as directed on the package, unless instructed differently by your doctor. If you are taking Anacin without a prescription, follow any warnings and precautions on the label.

If you miss a dose of Anacin and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Anacin.

Store Anacin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Anacin out of the reach of children and away from pets.

Anacin may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Anacin with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

Avoid large amounts of food or drink that have caffeine (eg, coffee, tea, cocoa, cola, chocolate). This includes any medicines that contain caffeine.

Anacin has aspirin in it. Before you start any new medicine, check the label to see if it has aspirin in it too. If it does or if you are not sure, check with your doctor or pharmacist.

Talk to your doctor before you take Anacin or other pain relievers/fever reducers if you drink more than 3 drinks with alcohol per day. Serious stomach ulcers or bleeding can occur with the use of Anacin. Taking it in high doses or for a long time, smoking, or drinking alcohol increases the risk of these side effects. Taking Anacin with food will NOT reduce the risk of these effects. Contact your doctor or emergency room at once if you develop severe stomach or back pain; black, tarry stools; vomit that looks like blood or coffee grounds; or unusual weight gain or swelling.

Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor. Taking more than the recommended dose or taking Anacin regularly may be habit-forming.

Anacin may reduce the number of clot-forming cells (platelets) in your blood. To prevent bleeding, avoid situations in which bruising or injury may occur. Report any unusual bleeding, bruising, blood in stools, or dark, tarry stools to your doctor.

Aspirin has been linked to a serious illness called Reye syndrome. Do not give Anacin to a child or teenager who has the flu, chickenpox, or a viral infection. Contact your doctor with any questions or concerns.

Diabetes patients - Anacin may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

If Anacin has a strong vinegar-like smell upon opening, do not use. It means the medicine is breaking down. Throw the bottle away safely and out of the reach of children; contact your pharmacist and replace.

Tell your doctor or dentist that you take Anacin before you receive any medical or dental care, emergency care, or surgery.

Do not take Anacin for at least 7 days after any surgery unless directed by your health care provider.

Do not take Anacin for more than 10 days for pain or for more than 3 days for fever unless directed to do so by your health care provider.

Different brands of Anacin may have different dosing instructions for CHILDREN. Follow the dosing instructions on the package labeling. If your doctor has given you instructions, follow those. If you are unsure of the dose to give a child, check with your doctor or pharmacist.

Do NOT use Anacin if:

you are allergic to any ingredient in Anacin

you are a child or teenager with influenza (flu) or chickenpox

you have bleeding problems such as hemophilia, von Willebrand disease, or low blood platelets, or you have active severe bleeding

you have had a severe allergic reaction (eg, severe rash, hives, breathing difficulties, dizziness) to aspirin, tartrazine, or a nonsteroidal anti-inflammatory drug (NSAID) (eg, ibuprofen, naproxen, celecoxib)

you are taking anticoagulants (eg, heparin, warfarin) or methotrexate

Before using Anacin:

Some medical conditions may interact with Anacin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have alcoholism or if you consume 3 or more alcohol-containing drinks every day

if you have asthma, bleeding or clotting problems, growths in the nose (nasal polyps), kidney or liver problems, stomach or intestinal problems (eg, ulcer, inflammation), heart problems, heartburn, upset stomach, stomach pain, hives, influenza (flu) or chickenpox, or vitamin K deficiency

if you have anxiety, trouble sleeping, or heart problems

if you are a child with a stroke, a weakened blood vessel (cerebral aneurysm) or bleeding in the brain, rheumatic disease (eg, rheumatoid arthritis), or Kawasaki syndrome (a rare inflammation causing heart problems in children)

Some MEDICINES MAY INTERACT with Anacin. Tell your health care provider if you are taking any other medicines.

PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Anacin while you are pregnant. Anacin is not recommended during the last 3 months (third trimester) of pregnancy because it may cause harm to the fetus. Anacin is found in breast milk. If you are or will be breast-feeding while you use Anacin, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects. Anacin's side effects may include dizziness, heartburn, irritability, nausea, nervousness, rashes, hives, bloody stools, drowsiness, hearing loss, ringing in the ears, and trouble sleeping.

Check with your doctor if any of the listed above most COMMON side effects persist or become bothersome.

Seek medical attention right away if any of these SEVERE side effects occur: severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black or bloody stools; confusion; diarrhea; drowsiness; hearing loss; ringing in the ears; severe or persistent dizziness; severe or persistent stomach pain or heartburn; shakiness; trouble sleeping; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects.

Anacin is a pain reliever intended for the temporary relief of minor aches and pains. Anacin is a combination salicylate and stimulant. It works by blocking several different chemical processes within the body that cause pain, inflammation, and fever. It also reduces the tendency for blood to clot.

Availability: In Stock (17 packs)

Other names of Anacin:

Anacin is used for treating pain including, headache, muscle aches, sprains, tooth extraction and toothache, menstrual cramps, arthritis and rheumatism, and pain and fever of the common cold. It may also be used for other conditions as determined by your doctor.

Use Anacin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take Anacin by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation. Taking it with food may not decrease the risk of stomach or bowel problems (eg, bleeding, ulcers) that may occur while taking Anacin.

Take Anacin with a full glass of water (8 oz/240 mL). Do not lie down for 30 minutes after taking Anacin.

Use Anacin exactly as directed on the package, unless instructed differently by your doctor. If you are taking Anacin without a prescription, follow any warnings and precautions on the label.

If you miss a dose of Anacin and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Anacin.

Store Anacin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Anacin out of the reach of children and away from pets.

Anacin may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Anacin with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

Avoid large amounts of food or drink that have caffeine (eg, coffee, tea, cocoa, cola, chocolate). This includes any medicines that contain caffeine.

Anacin has aspirin in it. Before you start any new medicine, check the label to see if it has aspirin in it too. If it does or if you are not sure, check with your doctor or pharmacist.

Talk to your doctor before you take Anacin or other pain relievers/fever reducers if you drink more than 3 drinks with alcohol per day. Serious stomach ulcers or bleeding can occur with the use of Anacin. Taking it in high doses or for a long time, smoking, or drinking alcohol increases the risk of these side effects. Taking Anacin with food will NOT reduce the risk of these effects. Contact your doctor or emergency room at once if you develop severe stomach or back pain; black, tarry stools; vomit that looks like blood or coffee grounds; or unusual weight gain or swelling.

Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor. Taking more than the recommended dose or taking Anacin regularly may be habit-forming.

Anacin may reduce the number of clot-forming cells (platelets) in your blood. To prevent bleeding, avoid situations in which bruising or injury may occur. Report any unusual bleeding, bruising, blood in stools, or dark, tarry stools to your doctor.

Aspirin has been linked to a serious illness called Reye syndrome. Do not give Anacin to a child or teenager who has the flu, chickenpox, or a viral infection. Contact your doctor with any questions or concerns.

Diabetes patients - Anacin may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

If Anacin has a strong vinegar-like smell upon opening, do not use. It means the medicine is breaking down. Throw the bottle away safely and out of the reach of children; contact your pharmacist and replace.

Tell your doctor or dentist that you take Anacin before you receive any medical or dental care, emergency care, or surgery.

Do not take Anacin for at least 7 days after any surgery unless directed by your health care provider.

Do not take Anacin for more than 10 days for pain or for more than 3 days for fever unless directed to do so by your health care provider.

Different brands of Anacin may have different dosing instructions for CHILDREN. Follow the dosing instructions on the package labeling. If your doctor has given you instructions, follow those. If you are unsure of the dose to give a child, check with your doctor or pharmacist.

Do NOT use Anacin if:

you are allergic to any ingredient in Anacin

you are a child or teenager with influenza (flu) or chickenpox

you have bleeding problems such as hemophilia, von Willebrand disease, or low blood platelets, or you have active severe bleeding

you have had a severe allergic reaction (eg, severe rash, hives, breathing difficulties, dizziness) to aspirin, tartrazine, or a nonsteroidal anti-inflammatory drug (NSAID) (eg, ibuprofen, naproxen, celecoxib)

you are taking anticoagulants (eg, heparin, warfarin) or methotrexate

Before using Anacin:

Some medical conditions may interact with Anacin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have alcoholism or if you consume 3 or more alcohol-containing drinks every day

if you have asthma, bleeding or clotting problems, growths in the nose (nasal polyps), kidney or liver problems, stomach or intestinal problems (eg, ulcer, inflammation), heart problems, heartburn, upset stomach, stomach pain, hives, influenza (flu) or chickenpox, or vitamin K deficiency

if you have anxiety, trouble sleeping, or heart problems

if you are a child with a stroke, a weakened blood vessel (cerebral aneurysm) or bleeding in the brain, rheumatic disease (eg, rheumatoid arthritis), or Kawasaki syndrome (a rare inflammation causing heart problems in children)

Some MEDICINES MAY INTERACT with Anacin. Tell your health care provider if you are taking any other medicines.

PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Anacin while you are pregnant. Anacin is not recommended during the last 3 months (third trimester) of pregnancy because it may cause harm to the fetus. Anacin is found in breast milk. If you are or will be breast-feeding while you use Anacin, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects. Anacin's side effects may include dizziness, heartburn, irritability, nausea, nervousness, rashes, hives, bloody stools, drowsiness, hearing loss, ringing in the ears, and trouble sleeping.

Check with your doctor if any of the listed above most COMMON side effects persist or become bothersome.

Seek medical attention right away if any of these SEVERE side effects occur: severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black or bloody stools; confusion; diarrhea; drowsiness; hearing loss; ringing in the ears; severe or persistent dizziness; severe or persistent stomach pain or heartburn; shakiness; trouble sleeping; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects.

Artane - Pain Relief, Tenvatil

Pain Relief - Tenvatil (Brand name: artane)

Artane is used to treat the stiffness, tremors, spasms, and poor muscle control of Parkinson's disease. It is also used to treat and prevent the same muscular conditions when they are caused by drugs such as chlorpromazine (Thorazine), fluphenazine (Prolixin), perphenazine (Trilafon), haloperidol (Haldol), thiothixene (Navane), and others.

Active Ingredient: Trihexyphenidyl

Availability: In Stock (14 Packages)

Artane alters unusual nerve impulses and relaxes stiff muscles.

Take trihexyphenidyl exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you. Take each dose with a full glass of water. Trihexyphenidyl may be taken with or without meals. Taking trihexyphenidyl with food may lessen stomach upset.

Before taking trihexyphenidyl, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: certain eye problem (narrow-angle glaucoma), blockage of the bladder/esophagus/stomach/intestines (e. g. bowel obstruction), severe ulcerative colitis.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: alcohol use, breathing problems (e. g. asthma, emphysema), diarrhea caused by an infection, certain eye problem.

To ensure that you get a correct dose, measure the liquid form of trihexyphenidyl with a special dose-measuring spoon or cup, not with a regular table spoon.

If you miss a dose take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and only take the next regularly scheduled dose. Do not take a double dose of this medication.

Dosage should be individualized. The initial dose should be low and then increased gradually, especially in patients over 60 years of age. Whether ARTANE (trihexyphenidyl HCl) may best be given before or after meals should be determined by the way the patient reacts. Postencephalitic patients, who are usually more prone to excessive salivation, may prefer to take it after meals and may, in addition, require small amounts of atropine which, under such circumstances, is sometimes an effective adjuvant. If ARTANE (trihexyphenidyl) tends to dry the mouth excessively, it may be better to take it before meals, unless it causes nausea. If taken after meals, the thirst sometimes induced can be allayed by mint candies, chewing gum or water.

Abrupt withdrawal of treatment for parkinsonism may result in acute exacerbation of parkinsonism symptoms; therefore, abrupt withdrawal should be avoided.

Abrupt withdrawal of treatment may result in neuroleptic malignant syndrome (NMS).

Store Artane at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep in a tight, light-resistant container. Keep Artane out of the reach of children and away from pets.

Dosage should be individualized. The initial dose should be low and then increased gradually, especially in patients over 60 years of age. Whether ARTANE (trihexyphenidyl HCl) may best be given before or after meals should be determined by the way the patient reacts. Postencephalitic patients, who are usually more prone to excessive salivation, may prefer to take it after meals and may, in addition, require small amounts of atropine which, under such circumstances, is sometimes an effective adjuvant. If ARTANE (trihexyphenidyl) tends to dry the mouth excessively, it may be better to take it before meals, unless it causes nausea. If taken after meals, the thirst sometimes induced can be allayed by mint candies, chewing gum or water.

Abrupt withdrawal of treatment for parkinsonism may result in acute exacerbation of parkinsonism symptoms; therefore, abrupt withdrawal should be avoided.

Abrupt withdrawal of treatment may result in neuroleptic malignant syndrome (NMS).

Store Artane at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep in a tight, light-resistant container. Keep Artane out of the reach of children and away from pets.

Patients with cardiac, liver, or kidney disorders, or with hypertension, should be closely monitored.

Since ARTANE (trihexyphenidyl) has atropine-like properties, patients on long-term treatment should be carefully monitored for untoward reactions.

Since ARTANE (trihexyphenidyl) has parasympatholytic activity, it should be used with caution in patients with glaucoma, obstructive disease of the gastrointestinal or genitourinary tracts, and in elderly males with possible prostatic hypertrophy. Incipient glaucoma may be precipitated by parasympatholytic drugs such as ARTANE (trihexyphenidyl).

Do not use Artane without first talking to your doctor if you have:

ever had an allergic reaction to it;

narrow-angle glaucoma;

an obstruction in the bowel or a complication of bowel disease known as megacolon; or

myasthenia gravis.

Before taking this medication, tell your doctor if you have:

enlargement of the prostate or difficulty urinating;

epilepsy or another seizure disorder;

heart disease or an irregular heartbeat;

depression or any other psychiatric illness;

kidney disease; or

liver disease.

You may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above. It is not known whether trihexyphenidyl will be harmful to an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is not known whether trihexyphenidyl passes into breast milk. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

Minor side effects, such as dryness of the mouth, blurred vision, dizziness, mild nausea or nervousness, will be experienced by 30 to 50 percent of all patients. These sensations, however, are much less troublesome with ARTANE (trihexyphenidyl) than with belladonna alkaloids and are usually less disturbing than unallenated parkinsonism. Such reactions tend to become less pronounced, and even to disappear, as treatment continues. Even before these reactions have remitted spontaneously, they may often be controlled by careful adjustment of dosage form, amount of drug, or interval between doses.

If you experience any of the following serious side effects, stop taking trihexyphenidyl and seek emergency medical attention or contact your doctor immediately:

an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);

fever;

fast or irregular heartbeats;

anxiety, hallucinations, confusion, agitation, hyperactivity, or loss of consciousness;

seizures;

eye pain; or

a rash.

Other, less serious side effects may be more likely to occur. Continue to take trihexyphenidyl and talk to your doctor if you experience:

dryness of the mouth;

large pupils or blurred vision;

drowsiness or dizziness;

difficulty urinating or constipation;

nervousness or anxiety;

upset stomach; or

decreased sweating.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

Artane is used to treat the stiffness, tremors, spasms, and poor muscle control of Parkinson's disease. It is also used to treat and prevent the same muscular conditions when they are caused by drugs such as chlorpromazine (Thorazine), fluphenazine (Prolixin), perphenazine (Trilafon), haloperidol (Haldol), thiothixene (Navane), and others.

Availability: In Stock (14 packs)

Other names of Artane:

Artane alters unusual nerve impulses and relaxes stiff muscles.

Take trihexyphenidyl exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you. Take each dose with a full glass of water. Trihexyphenidyl may be taken with or without meals. Taking trihexyphenidyl with food may lessen stomach upset.

Before taking trihexyphenidyl, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: certain eye problem (narrow-angle glaucoma), blockage of the bladder/esophagus/stomach/intestines (e. g. bowel obstruction), severe ulcerative colitis.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: alcohol use, breathing problems (e. g. asthma, emphysema), diarrhea caused by an infection, certain eye problem.

To ensure that you get a correct dose, measure the liquid form of trihexyphenidyl with a special dose-measuring spoon or cup, not with a regular table spoon.

If you miss a dose take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and only take the next regularly scheduled dose. Do not take a double dose of this medication.

Dosage should be individualized. The initial dose should be low and then increased gradually, especially in patients over 60 years of age. Whether ARTANE (trihexyphenidyl HCl) may best be given before or after meals should be determined by the way the patient reacts. Postencephalitic patients, who are usually more prone to excessive salivation, may prefer to take it after meals and may, in addition, require small amounts of atropine which, under such circumstances, is sometimes an effective adjuvant. If ARTANE (trihexyphenidyl) tends to dry the mouth excessively, it may be better to take it before meals, unless it causes nausea. If taken after meals, the thirst sometimes induced can be allayed by mint candies, chewing gum or water.

Abrupt withdrawal of treatment for parkinsonism may result in acute exacerbation of parkinsonism symptoms; therefore, abrupt withdrawal should be avoided.

Abrupt withdrawal of treatment may result in neuroleptic malignant syndrome (NMS).

Store Artane at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep in a tight, light-resistant container. Keep Artane out of the reach of children and away from pets.

Dosage should be individualized. The initial dose should be low and then increased gradually, especially in patients over 60 years of age. Whether ARTANE (trihexyphenidyl HCl) may best be given before or after meals should be determined by the way the patient reacts. Postencephalitic patients, who are usually more prone to excessive salivation, may prefer to take it after meals and may, in addition, require small amounts of atropine which, under such circumstances, is sometimes an effective adjuvant. If ARTANE (trihexyphenidyl) tends to dry the mouth excessively, it may be better to take it before meals, unless it causes nausea. If taken after meals, the thirst sometimes induced can be allayed by mint candies, chewing gum or water.

Abrupt withdrawal of treatment for parkinsonism may result in acute exacerbation of parkinsonism symptoms; therefore, abrupt withdrawal should be avoided.

Abrupt withdrawal of treatment may result in neuroleptic malignant syndrome (NMS).

Store Artane at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep in a tight, light-resistant container. Keep Artane out of the reach of children and away from pets.

Patients with cardiac, liver, or kidney disorders, or with hypertension, should be closely monitored.

Since ARTANE (trihexyphenidyl) has atropine-like properties, patients on long-term treatment should be carefully monitored for untoward reactions.

Since ARTANE (trihexyphenidyl) has parasympatholytic activity, it should be used with caution in patients with glaucoma, obstructive disease of the gastrointestinal or genitourinary tracts, and in elderly males with possible prostatic hypertrophy. Incipient glaucoma may be precipitated by parasympatholytic drugs such as ARTANE (trihexyphenidyl).

Do not use Artane without first talking to your doctor if you have:

ever had an allergic reaction to it;

narrow-angle glaucoma;

an obstruction in the bowel or a complication of bowel disease known as megacolon; or

myasthenia gravis.

Before taking this medication, tell your doctor if you have:

enlargement of the prostate or difficulty urinating;

epilepsy or another seizure disorder;

heart disease or an irregular heartbeat;

depression or any other psychiatric illness;

kidney disease; or

liver disease.

You may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above. It is not known whether trihexyphenidyl will be harmful to an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is not known whether trihexyphenidyl passes into breast milk. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

Minor side effects, such as dryness of the mouth, blurred vision, dizziness, mild nausea or nervousness, will be experienced by 30 to 50 percent of all patients. These sensations, however, are much less troublesome with ARTANE (trihexyphenidyl) than with belladonna alkaloids and are usually less disturbing than unallenated parkinsonism. Such reactions tend to become less pronounced, and even to disappear, as treatment continues. Even before these reactions have remitted spontaneously, they may often be controlled by careful adjustment of dosage form, amount of drug, or interval between doses.

If you experience any of the following serious side effects, stop taking trihexyphenidyl and seek emergency medical attention or contact your doctor immediately:

an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);

fever;

fast or irregular heartbeats;

anxiety, hallucinations, confusion, agitation, hyperactivity, or loss of consciousness;

seizures;

eye pain; or

a rash.

Other, less serious side effects may be more likely to occur. Continue to take trihexyphenidyl and talk to your doctor if you experience:

dryness of the mouth;

large pupils or blurred vision;

drowsiness or dizziness;

difficulty urinating or constipation;

nervousness or anxiety;

upset stomach; or

decreased sweating.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

Fanfic Flim, Flam And The Master Plan Ch 1, My Little Pony, X-Flam

Flim, Flam and the Master Plan by Broken Kindle

A/N: This is my first MLP fanfic. I've been waiting around for an idea that would work well and it came to me while drawing Flim and Flam - some headcanon started forming and it just spiralled from there. I can't guarantee when I'll update, but I'm hoping that this will be a multi-chaptered fic I actually finish. Reviews and crits are always welcomed, so don't be afraid to throw some my way. Without further ado I present you with the Prologue;

Flam repositioned the nozzle of the Super Speedy Cider Squeezy so that it sheltered his sleeping brother from the rain. The machine had taken a good few beatings and no longer worked in the way its creator had intended, but it made for better shelter than their straw hats or cardboard boxes. He had taken first watch again, sleep evading him in much the way they had evaded the projectiles thrown at them in whichever town they stumbled into. That had been before they had decided that living off the land surrounding towns and villages might be a better option, before they had discovered just how cruel other ponies could be. He cast a glance over to where his brother slept. Flim still walked with a limp in his right foreleg.

He folded one foreleg over the other as he looked back out at the surrounding wood and farmland, watching warily for possible dangers. Camping out like this in the middle of zap apple season had to be the worst idea they'd had yet, but there was simply no way Flim could walk the distance with his injured leg, and with his weakened body and magic Flam would have little hope of carrying him. They would just have to make do and hope the timberwolves didn't get to them. The brothers had narrowly avoided them last time and Flam did not want a repeat performance.

Since the Ponyville incident things have been getting steadily worse. Sweet Celestia, Ponyville. It seemed like such a long time ago now. Flam understood why the Apples had objected so vehemently to him and Flim coming along with the Super Speedy Cider Squeezy . The family had been living and working there for generations, and the brothers were only there to make profit, after all. But a pony had to make a living somehow, and Flam couldn't help but feel some resentment towards the residents of Ponyville for shunning them and spreading the news of what had happened. They had long since lost their trademark shirts and bowties, but ponies in the towns and villages still recognised the Flim Flam brothers and pushed them away.

Flam sighed. How had it all come to this?

Prilozheniya Na Google Play – Apo Cal, Apo-Cal

Описание

Don't miss the end of the world with this app!

Apo Cal. Apocalypse's Countdown.

And no, the Mayans did not predict the end of the world, but the end of the fifth cycle of their calendar. No, the one and only true date for the end of the world is Tue Jan 19 03:14:07 2038 .

Apocal indicates in real time the time remaining until the end of the world, but as it won't happen soon, this date can be customized according to each.

NEW. It's your turn to make predictions. Set your own date for the end of the world! =) click anywhere to show the menu.

Initially based upon the estimated date of the 21st December 2012, this application allow you to know precisely the time left before the end of the world.

Now with an amazing widget to remind your there's so little time!

Keywords for this useful app. 21th December 2012, Mayan calendar, prediction, armageddon, apocalypse, end of the world, judgement day, timer, countdown, Year-2039, Tue Jan 19 2038, BUG, POSIX.

Version 3.0. Upgraded date picker + icon design

Version 2.4. Bug fixes and optimisations.

Version 2.3. The new precise date of the end of the world is Tue Jan 19 03:14:07 2038 (cf. Year-2038 Bug).

Version 2.2. New buttons. you can now decide of your own armageddon's date!

Version 2.1. New clickable Widget to quickly remind your the remaining time.

Version 1.3. Graphical optimisations and internationalisation.

Не пропустите конец света с помощью этого приложения!

Апо Cal: Обратный отсчет Апокалипсиса.

И нет, майя не предсказывали конец мира, но и конец пятого цикла их календаря. Нет, один и только правда дата конца света является Вт 19 января 3:14:07 2038.

Apocal указывает в реальном времени время, оставшееся до конца света, но, как это не произойдет в ближайшее время, эта дата может быть настроена в соответствии с каждым.

NEW: Теперь твоя очередь делать прогнозы. Установите свой собственный дата для конца света! =) Щелкните в любом месте, чтобы показать меню.

Первоначально на основе предполагаемой даты 21 декабря 2012 года это приложение позволит вам точно знать, сколько времени осталось до конца света.

Теперь с удивительной виджета, чтобы напомнить ваш там так мало времени!

Ключевые слова для этого полезного приложения: 21 декабря 2012, календарю майя, предсказания, Армагеддон, Апокалипсис, конец света, судный день, таймера, таймер обратного отсчета, год-2039, Вт 19 января 2038, BUG, ??POSIX.

Версия 3.0: Модернизированный выбора даты + дизайн иконок

Версия 2.4: Исправление ошибок и оптимизация.

Версия 2.3: Новая точная дата конца света Пн 19 января 3:14:07 2038 (ср Год-2038 Буг).

Версия 2.2: Новые кнопки: теперь вы можете решить даты вашего собственного Армагеддона!

Версия 2.1: Новые кликабельны Виджет для быстрого напоминать оставшееся время.

Версия 1.3: Графические оптимизация и интернационализация.

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Buy Carlitex (Benicar) Online Without A Prescription, Carlitex

Buy Carlitex (Benicar) Without Prescription

Carlitex (Benicar) Description

Carlitex is an angiotensin II receptor antagonist. It works by inhibiting the action of a chemical transmitter (angiotensin II) and allowing the blood vessels to dilate (widen) and the kidneys to eliminate extra sodium and fluids. These actions combine to help lower blood pressure.

Generic name of Carlitex is Olmesartan.

Carlitex is also known as Olmesartan, Olmetec, Olmezest, Olmecip.

Brand name of Carlitex is Carlitex.

Carlitex (Benicar) Dosage

Carlitex is available in:

20mg Low Dosage

40mg Standard Dosage

Take Carlitex orally with or without food.

If you want to achieve most effective results do not stop taking Carlitex suddenly.

Carlitex (Benicar) Missing of dose

Do not take double dose. If you miss a dose you should take it as soon as you remember about your missing. If it is the time for the next dose you should continue your regular dosing schedule.

Carlitex (Benicar) Overdose

If you overdose Carlitex and you don't feel good you should visit your doctor or health care provider immediately.

Carlitex (Benicar) Storage

Store your medicine at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children and in a container that small children cannot open.

Carlitex (Benicar) Side effects

Carlitex has its side effects. The most common are:

abdominal or stomach pain

cough

diarrhea

dizziness

headache

unusual tiredness

Less common but more serious side effects during taking Carlitex:

allergy reactions (urticaria, breathing difficulties, rash, and eruption)

fainting

increased heartbeat

lightheadedness

Side effects manifestations are not only depend on medicine you are taking but also depend on your health state and on the other factors.

Carlitex (Benicar) Contra-indications

Do not take Carlitex if you are allergic to Carlitex components.

Do not take Carlitex if you're pregnant or you plan to have a baby, or you are a nursing mother.

Avoid machine driving.

Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment.

Be careful if you use salt substitute or a product that has potassium in it.

Do not stop taking Carlitex suddenly.

Carlitex (Benicar) Frequently asked questions

Q: What is Carlitex?

A: Carlitex is used for treating high blood pressure, alone or with other medicines. It may also be used for other conditions. Carlitex is an angiotensin II receptor antagonist. It works by inhibiting the action of a chemical transmitter (angiotensin II) and allowing the blood vessels to dilate (widen) and the kidneys to eliminate extra sodium and fluids. These actions combine to help lower blood pressure.

Q: How should I take Carlitex?

A: Carlitex is available in tablets (20 mg, 40 mg). Take Carlitex orally with or without food. If you want to achieve most effective results do not stop taking Carlitex suddenly.

Q: What should I do in case of overdose?

A: Do not take Carlitex tablets in large quantities. In case of Carlitex overdosage, you need to visit doctor or health care provider immediately.

Q: Is it possible to drink alcohol?

A: No, it is forbidden to drink alcohol.

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Ciproxin Tablets 500mg, Ciprokin

CIPROXIN TABLETS 500MG

Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.

Clonidine - Side Effects, Dosage, Interactions, Clonisin

Clonidine

Clonidine is the generic name of Catapres, a medication used to treat high blood pressure .

Clonidine works by slowing down your heart rate and relaxing blood vessels. You can take clonidine alone or in combination with other medications to lower blood pressure.

Clonidine is in a class of medications called centrally acting alpha-agonist hypotensive agents.

The Food and Drug Administration (FDA) approved clonidine in 1974 for the drug company Boehringer Ingelheim under the brand name Catapres.

The FDA approved generic forms of clonidine in 2009 for several drug companies. Kapvay is another brand name for clonidine.

According to the National Institutes of Health, Consumer Reports and other sources, it's not uncommon for doctors to prescribe clonidine to treat other conditions, including:

Painful menstrual periods

Tourette's syndrome

Attention deficit hyperactivity disorder (ADHD)

Hot flashes from menopause

Smoking cessation

Withdrawal, or detox, from addiction to opioid narcotic drugs (heroin and morphine, for example)

Alcohol abuse or alcoholism

Restless legs syndrome (RLS)

Diabetes-linked diarrhea

Severe cancer pain (in combination with other drugs)

Research published in January 2014 in The Cochrane Library also found that giving children clonidine before surgery could help ease pain after an operation.

However, the potential use of clonidine for post-surgical pain relief requires more research.

Clonidine 'High' and Abuse

According to a 2014 report published in the Journal of Addiction Medicine. clonidine is often abused in combination with opioid narcotics such as methadone, codeine, or heroin.

The authors of the report wrote, "Clonidine reportedly boosts and extends the opioid-related 'high' and reduces the amount of psychoactive drug needed. Clonidine may be easier to acquire than some other drugs of abuse due to limited awareness of its abuse potential and low cost."

Signs of a clonidine addiction or abuse may include any of the following:

An inability to control the use of clonidine

Ignoring your duties at home, work, or school due to clonidine use

Using clonidine despite physical or mental health issues

Increased tolerance, or needing larger amounts of clonidine to feel its effects

Having withdrawal symptoms when you stop using clonidine, or using the drug to avoid withdrawal symptoms

Clonidine Withdrawal

It's dangerous to stop taking clonidine suddenly because that can cause a dangerous withdrawal reaction.

Symptoms of clonidine withdrawal can include:

Nervousness

Headache

Tremor or shaking

A rapid rise in blood pressure

You may be at higher risk for a rise in blood pressure if you are taking clonidine in large doses or if you are taking it along with another blood pressure medication called a beta-blocker .

In rare cases, this reaction can be fatal.

Don't stop taking clonidine on your own. If you need to stop taking clonidine, your doctor will advise you about how to gradually reduce your dose over several days.

Clonidine Warnings

Always tell your doctor if you have allergies to any medications.

Talk to your doctor about the danger of stopping clonidine suddenly, especially if you have any upcoming surgical procedures.

Most likely you will continue to take clonidine until just before surgery, and start up again soon after surgery. Doctors should monitor your blood pressure carefully during surgery.

Use clonidine cautiously if you have a history of heart problems or stroke. and make sure doctor is aware you have had these conditions.

Your doctor will also want to know, before starting you on clonidine, if you have any of these other conditions:

Heart disease

Previous heart attack

Previous stroke

A heart rhythm abnormality such as atrial fibrillation (afib) or ventricular fibrillation (vfib)

Kidney disease

Clonidine and Pregnancy

If you're a woman, let your doctor know if you are or could be pregnant or if you're breastfeeding.

There's not enough evidence to determine whether clonidine is safe to take during pregnancy, but experts do know that clonidine passes into breast milk.

If you become pregnant while taking clonidine, let your doctor know right away. Also, ask your doctor about breastfeeding before taking clonidine.

Children younger than 12 should not take clonidine.

Clonidine comes in tablets of 0.1, 0.2, and 0.3 milligrams (mg), and your doctor will try to find the lowest dose of clonidine that works for you.

You usually take clonidine twice a day at about the same times. A typical dose schedule for an adult with high blood pressure is 0.1 mg taken in the morning and at bedtime.

Your doctor may increase your dose by 0.1 mg each week until you have a good response. In most cases, a daily dose will end up between 0.2 and 0.6 mg given in divided doses.

People older than 65 and those with kidney disease may need to take lower doses of clonidine.

Clonidine Overdose

Symptoms of a clonidine overdose may include:

High blood pressure followed by low blood pressure

Difficulty breathing

Low body temperature

Drowsiness

Weakness

Irritability

Symptoms usually occur within 30 minutes of an overdose, and children are much more likely to have symptoms of an overdose than adults.

A large overdose can cause abnormal heart rhythms, inability to breathe, seizure, and coma.

If you think you or someone else have taken an overdose of clonidine, call a poison control center at 1-800-222-1222 or call 911.

Missed Dose of Clonidine

Take clonidine exactly as directed by your doctor. Don't take more or less.

If you miss a dose of clonidine, take the missed dose as soon as you remember. If it's almost time for your next dose, skip the missed dose and continue your regular dosing schedule.

Don't double your dose to make up for the missed one.

Q: My 13-year-old's doctor wants to start him on clonidine for sleep. He was on melatonin for three years. As a parent I have some concerns with this. I would really appreciate any feedback.

A: Clonidine (Catapres) is sometimes used to treat insomnia or sleep problems in children with attention deficit disorder (ADD/ADHD) or autistic spectrum disorders. Common side effects include dry mouth, headache, nausea, constipation, and fatigue. Serious side effects include allergic reactions, slowed heart rate, and changes in blood pressure. You should share your concerns with your son's doctor, and ask about appropriate monitoring for these side effects if your son takes clonidine. You can find more information on clonidine here: http://www. everydayhealth. com/drugs/clonidine.

Q: Is clonidine safe as a long term medication?

A: The package insert for clonidine does not recommend a limit on the amount of time that clonidine should be used. There is evidence in the medical literature that clonidine, when used long-term, is safe, effective, and well tolerated. This information is solely educational. It is important for patients to consult their physician or healthcare provider about any specific question regarding their medical conditions or medications; particularly before taking any action. Derek Dore, PharmD

Q: Why does the drug clonidine seem to be the drug of choice by doctors in eastern Kentucky?

A: Clonidine lowers blood pressure by decreasing the levels of certain chemicals in your blood. This allows your blood vessels (veins and arteries) to relax (widen) and your heart to beat more slowly and easily. Clonidine is used to treat hypertension (high blood pressure). Consult your healthcare provider for specific information about the prescribing practices in your area. Sarah Lewis, PharmD

Q: I have high blood pressure and am taking Catapres TTS-2 Patch. I've noticed mild swelling in my feet and ankles. Could this be related to the Catapres?

A: It is possible that the swelling is related to taking Catapres TTS (clonidine transdermal). However, swelling in the feet and ankles is not listed as a common reaction or side effect to this medication. Side effects are patient-specific and often dose-related. Please check with your physician if the condition persists.

Q: If I miss my dosage of clonidine at night, the next day I am extremely nauseated and dizzy. Is this normal?

A: Clonidine (Catapress) is a medication prescribed for the treatment of hypertension. Clonidine has also been prescribed to treat opiate withdrawal symptoms and attention deficit syndrome in children. A search of the prescribing literature for clonidine lists dizziness as a common side effect and nausea and vomiting as less frequent side effects. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. Consuelo Worley, RPh

Q: Does clonidine cause weight gain?

A: Drugs can cause weight gain in several different ways. Some can increase appetite or make you crave certain types of foods like those high in carbohydrates or fat. Other medications may slow down metabolism or cause fluid retention. However, the effect of prescription drugs on body weight is complex. Some drugs have no effect on weight, while others cause weight gain or weight loss. Also, the same medications can cause weight gain in certain individuals and weight loss in others. There are also drugs that initially cause weight loss and then lead to weight gain with long-term use. Most prescription medications associated with changes in body weight affect the central nervous system. These include antidepressants like monoamine oxidase inhibitors (MAOIs), tricyclic antidepressants, and selective serotonin reuptake inhibitors (SSRIs). Mood stabilizers (lithium, valproic acid), antipsychotics, and anticonvulsants have also been linked with weight gain. Other drugs that have been reported to cause weight gain include diabetes medications (insulin, sulfonylureas, and thiazolidinediones), antihypertensive drugs, certain hormonal contraceptives, corticosteroids, antihistamines, some chemotherapy regimens, and antiretroviral protease inhibitors. Catapres (clonidine) is a medication that is used in the treatment of high blood pressure. The most common side effects with clonidine are dry mouth, drowsiness, dizziness, constipation, sedation, low blood pressure, weakness, and nausea. A search of the prescribing information did not specifically list weight gain as a side effect. This is not a complete list of the side effects associated with clonidine. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action. If you think a drug you are taking is causing weight gain, tell your health care provider. Do not stop any medication or change the dose without first talking to your provider. Megan Uehara, PharmD

Q: Dealing with diabetes and trying to get my numbers down, I took atenolol for 14 yrs at bedtime for blood pressure. Now instead I'm on clonidine. My numbers for blood sugar are high in the morning. Recently, I took 1/2 of a pill at night. My numbers are a little lower in the morning, about 50 pts lower. Does clonidine affect blood sugar levels?

A: I have reviewed your question regarding Tenormin (atenolol), Catapres (clonidine) and your blood glucose levels. I can find nothing in the available literature to indicate that Catapres (clonidine) will alter your blood glucose level. You may find the information on Everyday Health under the Diabetes Center useful: http://www. everydayhealth. com/diabetes/index. aspx For immediate questions or concerns, please contact your physician or health care provider. Joseph Hall, RPh

Q: How does clonidine help people quit smoking?

A: Clonidine (Catapress) is a blood pressure medication that has been studied as a second line agent for smoking cessation. In clinical studies, Clonidine along with behavioral therapy was effective at decreasing irritability symptoms, anxiety symptoms, and nicotine cravings in heavy smokers. The Clonidine patch was more effective than the oral tablets in decreasing these withdrawal symptoms and nicotine cravings. However, the exact mechanism by which clonidine decreases irritability, anxiety, and the nicotine cravings in unknown. Clonidine has also been effective in managing withdrawal symptoms in the treatment of alcoholism and opiate dependency. Clonidine has many side effects which limit its use in smoking cessation. These side effects include dry mouth, drowsiness, dizziness, constipation, sudden drops in blood pressure and skin irritation. Consuelo Worley, RPH

Q: I was prescribed clonidine for high blood pressure a week ago. Now, my mouth is dry and all food has a strange, somewhat sour, taste. Will this diminish over time or will it continue, as it seems to get worse each day?

A: One of the common negative responses for Catapres (clonidine) has been reports of a dry mouth. According to the prescribing information for clonidine, taking the larger portion of the daily dose at night may help minimize the dry mouth and drowsiness experienced. However, do not change how you take the medication, without first consulting your health care provider. Taste alteration was not listed in the prescribing information as a possible side effect. If your reactions do not improve in the near future, you may want to let your doctor know, as there are many different medications used to approach the management of hypertension (high blood pressure). You or your doctor are also encouraged to report your reactions to the FDA (Food and Drug Administration) at 1-800-FDA-1088. Catapres (clonidine) is an alpha-blocker that is not used as often anymore, but can be an excellent choice in some cases. Other options may include the diuretic "water pills," such as Lasix (furosemide) or HCTZ (hydrochlorothiazide); the calcium channel blockers, such as Norvasc (amlodipine); beta-blockers, such as Lopressor (metoprolol); and ACE (angiotensin converting enzyme) inhibitors or ARBs (angiotensin receptor blockers), such as Zestril/Prinivil (lisinopril) or Cozaar (losartan). Sometimes medications from more than one of these groups are used as well to control the blood pressure. Everyone reacts differently to medications, so it is important that you work with your doctor to find the best option available for your specific circumstances. Patti Brown, PharmD

By Chris Iliades, MD, and Mary Elizabeth Dallas | Medically Reviewed by Niya Jones, MD, MPH

Latest Update: 2014-07-23

Actoplus Met, Cipla-Pioglitazone

Cipla-pioglitazone is used for treating type 2 diabetes. It is used along with diet and exercise. It may be used alone or with other antidiabetic medicines.

Use Cipla-pioglitazone as directed by your doctor. Check the label on the medicine for exact dosing instructions. An extra patient leaflet is available with Cipla-pioglitazone. Talk to your pharmacist if you have questions about this information. Take Cipla-pioglitazone by mouth with meals. Take Cipla-pioglitazone on a regular schedule to get the most benefit from it. Taking Cipla-pioglitazone at the same times each day will help you remember to take it. Continue to take Cipla-pioglitazone even if you feel well. Do not miss any doses.

Drug Class and Mechanism

Cipla-pioglitazone is a biguanide and thiazolidinedione antidiabetic combination. It works by decreasing the amount of sugar the liver produces and the intestines absorb. It also helps to make your body more sensitive to the insulin that you naturally produce.

If you miss a dose of Cipla-pioglitazone. take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Store this medicine at room temperature at 77 degrees F (25 degrees C) in a tightly-closed container, away from heat, moisture, and light. Brief storage between 59 and 86 degrees F (15 and 30 degrees C) is permitted.

Do NOT use Cipla-pioglitazone if: you are allergic to any ingredient in Cipla-pioglitazone you have type 1 diabetes you have moderate to severe heart failure you have a severe infection, low blood oxygen levels, kidney or liver problems, or high blood ketone or acid levels (eg, diabetic ketoacidosis), or you are severely dehydrated you have had a stroke or a recent heart attack, or you are in shock you are 80 years old or more and have not had a kidney function test you will be having surgery or certain lab procedures you have a history of liver problems, including jaundice (yellowing of the skin or eyes), during therapy with a similar medicine called troglitazone

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Cipla-pioglitazone. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you: if you are pregnant, planning to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have a history of heart problems (eg, heart failure), abnormal liver function tests, lung or breathing problems, thyroid problems, stomach or bowel problems (eg, paralysis, blockage), adrenal or pituitary problems, eye or vision problems (eg, macular degeneration), bladder cancer, or lactic acidosis if you have fluid retention or swelling problems, vomiting, diarrhea, poor health or nutrition, low blood calcium or vitamin B12 levels, or anemia, or if you are dehydrated if you have an infection, fever, recent injury, or moderate to severe burns if you have a history of bone fracture, weak bones (eg, osteoporosis), or low calcium intake if you drink alcohol or have a history of alcohol abuse if you will be having surgery or certain lab procedures if you take a beta-blocker (eg, propranolol) Some MEDICINES MAY INTERACT with Cipla-pioglitazone. Tell your health care provider if you are taking any other medicines, especially any of the following: Amiloride, cimetidine, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, or vancomycin because they may increase the risk of Cipla-pioglitazone 's side effects Calcium channel blockers (eg, nifedipine), corticosteroids (eg, prednisone), diuretics (eg, furosemide, hydrochlorothiazide), estrogen, hormonal contraceptives (eg, birth control pills), insulin, isoniazid, nicotinic acid, oral antidiabetics (eg, glipizide), phenothiazines (eg, chlorpromazine), phenytoin, sympathomimetics (eg, albuterol, pseudoephedrine), or thyroid hormones (eg, levothyroxine) because the risk of high or low blood sugar may be increased Gemfibrozil because it may increase the risk of Cipla-pioglitazone 's side effects Rifampin because it may decrease Cipla-pioglitazone 's effectiveness, resulting in high blood sugar Anticoagulants (eg, warfarin) because their effectiveness may be decreased or the risk of their side effects may be increased by Actoplus Met

Possible Side Effects

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome: Cold-like symptoms; diarrhea; headache; indigestion; mild weight gain; nausea; stomach upset.

Seek medical attention right away if any of these SEVERE side effects occur: Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision or other vision changes; bone pain; chest pain or discomfort; dark urine; difficult or painful urination; dizziness or lightheadedness; fainting; fast or difficult breathing; feeling of being unusually cold; general feeling of being unwell; muscle pain or weakness; pale stools; persistent loss of appetite; severe or persistent headache, nausea, or vomiting; shortness of breath; slow or irregular heartbeat; sudden unexplained weight gain; swelling of the hands, ankles, or feet; unusual stomach pain or discomfort; unusual drowsiness; unusual tiredness or weakness; yellowing of the eyes or skin.

If you have any questions about Cipla-pioglitazone. please talk with your doctor, pharmacist, or other health care provider. Cipla-pioglitazone is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor. If using Cipla-pioglitazone for an extended period of time, obtain refills before your supply runs out.

Azahexal At The Medical Dictionary, Azahexal

Azahexal

Azathioprine is a chemotherapy drug, now rarely used for chemotherapy but more for immunosuppression in organ transplantation and autoimmune disease such as rheumatoid arthritis or inflammatory bowel disease or Crohn's disease. It is a pro-drug, converted in the body to the active metabolite 6-mercaptopurine. more.

Azathioprine was first introduced into clinical practice by Sir Roy Calne, the British pioneer in transplantation. Following the work done by Sir Peter Medawar in discovering the immunological basis of rejection of transplanted tissues and organs, Calne introduced 6-mercaptopurine as an experimental immunosuppressant for kidney transplants. When azathioprine was discovered, he then introduced it as a less toxic replacement for 6-mercaptopurine. For many years, dual therapy with azathioprine and steroids was the standard anti-rejection regime, until cyclosporine was introduced into clinical practice (also by Calne) in 1978.

Azathioprine acts to inhibit purine synthesis necessary for the proliferation of cells, especially leukocytes and lymphocytes. It is a safe and effective drug used alone in certain autoimmune diseases, or in combination with other immunosuppressants in organ transplantation. Its most severe side effect is bone marrow suppression, and it should not be given in conjunction with purine analogues such as allopurinol. The enzyme thiopurine S-methyltransferase (TPMT) deactivates 6-mercaptopurine. Genetic polymorphisms of TPMT can lead to excessive drug toxicity, thus assay of serum TPMT may be useful to prevent this complication.

Mycophenolate mofetil is increasingly being used in place of azathioprine in organ transplantation, but azathioprine certainly still has a major role.

Mycophenolate mofetil (MMF): seven RCTs compared MMF to azathioprine (AZA). MMF reduced the incidence of acute rejection. There was no significant difference in patient survival or graft loss at 1-year or 3-year follow-up. There appeared to be differences in the side-effect profiles of MMF and AZA. No RCTs comparing MMF with azathioprine were identified. Woodroffe R, Yao GL, Meads C, Bayliss S, Ready A, Raftery J, et al. Clinical and cost-effectiveness of newer immunosuppressive regimens in renal transplantation: a systematic review and modelling study. Health Technol Assess 2005;9(21).

Reference

Konstantopoulou M, Belgi A, Griffiths KD, Seale JR, Macfarlane AW. Azathioprine-induced pancytopenia in a patient with pompholyx and deficiency of erythrocyte thiopurine methyltransferase. BMJ 2005;330:350-1. PMID 15705694.

Buy Ceti-Puren - Cetirizine - Online Without Prescriptions, Ceti-Puren

Zyrtec (Ceti-puren)

Zyrtec (cetirizine) is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Zyrtec is used to treat cold or allergy symptoms such as sneezing, itching, watery eyes, or runny nose.

Zyrtec is also used to treat itching and swelling caused by chronic urticaria (hives).

Zyrtec may also be used for purposes not listed in this medication guide.

Use Zyrtec exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

You may take Zyrtec with or without food.

The chewable tablet must be chewed before you swallow it.

Do not swallow the Zyrtec dissolving tablet whole. Allow it to dissolve in your mouth without chewing. Swallow several times as the tablet dissolves. If desired, you may drink liquid to help swallow the dissolved tablet.

Call your doctor if your symptoms do not improve, if they get worse, or if you also have a fever. Store this medicine at room temperature away from moisture and heat. Do not allow the liquid form of this medicine to freeze.

Use Zyrtec exactly as directed on the label, or as prescribed by your doctor.

Ask your health care provider any questions you may have about how to use Zyrtec.

Store at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture. Brief storage between 59-86 degrees F (15-30 degrees C) is permitted. Or store in the refrigerator between 36-46 degrees F (2-8 degrees C). Do not store in the bathroom. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Active ingredient: Cetirizine

Inactive ingredients: colloidal silicon dioxide, croscarmellose sodium, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, polyethylene glycol, titanium dioxide

Do NOT use Zyrtec if:

You are allergic to any ingredient in Zyrtec or to hydroxyzine Contact your doctor or health care provider right away if any of these apply to you. Some medical conditions may interact with Zyrtec. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you: if you are pregnant, plan to become pregnant, or are breast-feeding if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement if you have allergies to medicines, foods, or other substances if you have kidney or liver problems, or are receiving dialysis

Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Zyrtec ; it may add to their effects.

Ask a doctor or pharmacist if it is safe for you to take this medicine if you have any medical conditions.

Tell your doctor if you regularly use other medicines that make you sleepy (such as other cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by Zyrtec.

This list is not complete and other drugs may interact with Zyrtec. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Important safety information:

Do not use with any other antihistamines applied to the skin (such as diphenhydramine cream, ointment, spray) because increased side effects may occur.

If you are scheduled for allergy testing, ask your doctor if you should stop taking this medication for several days before testing. This drug may affect your allergy test results.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and health care provider.

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Zyrtec:

Drowsiness; dry mouth; stomach pain (in children); tiredness; trouble sleeping (in children).

Seek medical attention right away if any of these SEVERE side effects occur when using Zyrtec:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); dark urine; fainting; fast or irregular heartbeat; mental or mood changes; persistent fatigue; seizures; severe dizziness; unusual bruising or bleeding; yellowing of eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects.

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Ciproxin Tablets 500mg - Summary Of Product Characteristics (Spc), Ciploxx

Ciproxin Tablets 500mg

250-500 mg every 24 h

In patients with impaired liver function no dose adjustment is required.

Dosing in children with impaired renal and/or hepatic function has not been studied.

Method of administration

Tablets are to be swallowed unchewed with fluid. They can be taken independent of mealtimes. If taken on an empty stomach, the active substance is absorbed more rapidly. Ciprofloxacin tablets should not be taken with dairy products (e. g. milk, yoghurt) or mineral-fortified fruit-juice (e. g. calcium-fortified orange juice) (see section 4.5).

In severe cases or if the patient is unable to take tablets (e. g. patients on enteral nutrition), it is recommended to commence therapy with intravenous ciprofloxacin until a switch to oral administration is possible.

• Hypersensitivity to the active substance, to other quinolones or to any of the excipients listed in section 6.1.

• Concomitant administration of ciprofloxacin and tizanidine (see section 4.5).

4.4 Special warnings and precautions for use

Severe infections and mixed infections with Gram-positive and anaerobic pathogens

Ciprofloxacin monotherapy is not suited for treatment of severe infections and infections that might be due to Gram-positive or anaerobic pathogens. In such infections ciprofloxacin must be co-administered with other appropriate antibacterial agents.

Streptococcal Infections (including Streptococcus pneumoniae)

Ciprofloxacin is not recommended for the treatment of streptococcal infections due to inadequate efficacy .

Genital tract infections

Gonococcal uretritis, cervicitis, epididymo-orchitis and pelvic inflammatory diseases may be caused by fluoroquinolone-resistant Neisseria gonorrhoeae isolates.

Therefore, ciprofloxacin should be administered for the treatment of gonococcal uretritis or cervicitis only if ciprofloxacin-resistant Neisseria gonorrhoeae can be excluded.

For epididymo-orchitis and pelvic inflammatory diseases, empirical ciprofloxacin should only be considered in combination with another appropriate antibacterial agent (e. g. a cephalosporin) unless ciprofloxacin-resistant Neisseria gonorrhoeae can be excluded. If clinical improvement is not achieved after 3 days of treatment, the therapy should be reconsidered.

Urinary tract infections

Resistance to fluoroquinolones of Escherichia coli – the most common pathogen involved in urinary tract infections – varies across the European Union. Prescribers are advised to take into account the local prevalence of resistance in Escherichia coli to fluoroquinolones.

The single dose of ciprofloxacin that may be used in uncomplicated cystitis in pre-menopausal women is expected to be associated with lower efficacy than the longer treatment duration. This is all the more to be taken into account as regards the increasing resistance level of Escherichia coli to quinolones.

There are limited data on the efficacy of ciprofloxacin in the treatment of post-surgical intra-abdominal infections.

The choice of ciprofloxacin should take into account information on resistance to ciprofloxacin in relevant pathogens in the countries visited.

Infections of the bones and joints

Ciprofloxacin should be used in combination with other antimicrobial agents depending on the results of the microbiological documentation.

Use in humans is based on in-vitro susceptibility data and on animal experimental data together with limited human data. Treating physicians should refer to national and/or international consensus documents regarding the treatment of anthrax.

The use of ciprofloxacin in children and adolescents should follow available official guidance. Ciprofloxacin treatment should be initiated only by physicians who are experienced in the treatment of cystic fibrosis and/or severe infections in children and adolescents.

Ciprofloxacin has been shown to cause arthropathy in weight-bearing joints of immature animals. Safety data from a randomised double-blind study on ciprofloxacin use in children (ciprofloxacin: n=335, mean age = 6.3 years; comparators: n=349, mean age = 6.2 years; age range = 1 to 17 years) revealed an incidence of suspected drug-related arthropathy (discerned from joint-related clinical signs and symptoms) by Day +42 of 7.2% and 4.6%. Respectively, an incidence of drug-related arthropathy by 1-year follow-up was 9.0% and 5.7%. The increase of suspected drug-related arthropathy cases over time was not statistically significant between groups. Treatment should be initiated only after a careful benefit/risk evaluation, due to possible adverse events related to joints and/or surrounding tissue (see section 4.8).

Broncho-pulmonary infections in cystic fibrosis

Clinical trials have included children and adolescents aged 5-17 years. More limited experience is available in treating children between 1 and 5 years of age.

Complicated urinary tract infections and pyelonephritis

Ciprofloxacin treatment of urinary tract infections should be considered when other treatments cannot be used, and should be based on the results of the microbiological documentation.

Clinical trials have included children and adolescents aged 1-17 years.

Other specific severe infections

Other severe infections in accordance with official guidance, or after careful benefit-risk evaluation when other treatments cannot be used, or after failure to conventional therapy and when the microbiological documentation can justify a ciprofloxacin use.

The use of ciprofloxacin for specific severe infections other than those mentioned above has not been evaluated in clinical trials and the clinical experience is limited. Consequently, caution is advised when treating patients with these infections.

Hypersensitivity and allergic reactions, including anaphylaxis and anaphylactoid reactions, may occur following a single dose (see section 4.8) and may be life-threatening. If such reaction occurs, ciprofloxacin should be discontinued and an adequate medical treatment is required.

Ciprofloxacin should generally not be used in patients with a history of tendon disease/disorder related to quinolone treatment. Nevertheless, in very rare instances, after microbiological documentation of the causative organism and evaluation of the risk/benefit balance, ciprofloxacin may be prescribed to these patients for the treatment of certain severe infections, particularly in the event of failure of the standard therapy or bacterial resistance, where the microbiological data may justify the use of ciprofloxacin.

Tendinitis and tendon rupture (especially Achilles tendon), sometimes bilateral, may occur with ciprofloxacin, even within the first 48 hours of treatment. Inflammation and ruptures of tendon may occur even up to several months after discontinuation of ciprofloxacin therapy. The risk of tendinopathy may be increased in elderly patients or in patients concomitantly treated with corticosteroids (see section 4.8).

At any sign of tendinitis (e. g. painful swelling, inflammation), ciprofloxacin treatment should be discontinued. Care should be taken to keep the affected limb at rest.

Ciprofloxacin should be used with caution in patients with myasthenia gravis, because symptoms can be exacerbated (see section 4.8).

If vision becomes impaired or any effects on the eyes are experienced, an eye specialist should be consulted immediately.

Ciprofloxacin has been shown to cause photosensitivity reactions. Patients taking ciprofloxacin should be advised to avoid direct exposure to either extensive sunlight or UV irradiation during treatment (see section 4.8).

Central Nervous System

Ciprofloxacin like other quinolones are known to trigger seizures or lower the seizure threshold. Cases of status epilepticus have been reported. Ciprofloxacin should be used with caution in patients with CNS disorders which may be predisposed to seizure. If seizures occur ciprofloxacin should be discontinued (see section 4.8). Psychiatric reactions may occur even after first administration of ciprofloxacin. In rare cases, depression or psychosis can progress to suicidal ideations/thoughts culminating in attempted suicide or completed suicide. In the occurrence of such cases, ciprofloxacin should be discontinued.

Cases of polyneuropathy (based on neurological symptoms such as pain, burning, sensory disturbances or muscle weakness, alone or in combination) have been reported in patients receiving ciprofloxacin. Ciprofloxacin should be discontinued in patients experiencing symptoms of neuropathy, including pain, burning, tingling, numbness, and/or weakness in order to prevent the development of an irreversible condition (see section 4.8).

Caution should be taken when using fluoroquinolones, including ciprofloxacin, in patients with known risk factors for prolongation of the QT interval such as, for example:

• congenital long QT syndrome

• concomitant use of drugs that are known to prolong the QT interval (e. g. Class IA and III anti-arrhythmics, tricyclic antidepressants, macrolides, antipsychotics)

• uncorrected electrolyte imbalance (e. g. hypokalaemia, hypomagnesaemia)

• cardiac disease (e. g. heart failure, myocardial infarction, bradycardia)

Elderly patients and women may be more sensitive to QTc-prolonging medications. Therefore, caution should be taken when using fluoroquinolones, including ciprofloxacin, in these populations.

(See section 4.2 Elderly patients, section 4.5, section 4.8, section 4.9).

As with other quinolones, hypoglycemia has been reported most often in diabetic patients, predominantly in the elderly population. In all diabetic patients, careful monitoring of blood glucose is recommended (see section 4.8).

The occurrence of severe and persistent diarrhoea during or after treatment (including several weeks after treatment) may indicate an antibiotic-associated colitis (life-threatening with possible fatal outcome), requiring immediate treatment (see section 4.8). In such cases, ciprofloxacin should immediately be discontinued, and an appropriate therapy initiated. Anti-peristaltic drugs are contraindicated in this situation.

Renal and urinary system

Crystalluria related to the use of ciprofloxacin has been reported (see section 4.8). Patients receiving ciprofloxacin should be well hydrated and excessive alkalinity of the urine should be avoided.

Impaired renal function

Since ciprofloxacin is largely excreted unchanged via renal pathway dose adjustment is needed in patients with impaired renal function as described in section 4.2 to avoid an increase in adverse drug reactions due to accumulation of ciprofloxacin.

Cases of hepatic necrosis and life-threatening hepatic failure have been reported with ciprofloxacin (see section 4.8). In the event of any signs and symptoms of hepatic disease (such as anorexia, jaundice, dark urine, pruritus, or tender abdomen), treatment should be discontinued.

Glucose-6-phosphate dehydrogenase deficiency

Haemolytic reactions have been reported with ciprofloxacin in patients with glucose-6-phosphate dehydrogenase deficiency. Ciprofloxacin should be avoided in these patients unless the potential benefit is considered to outweigh the possible risk. In this case, potential occurrence of haemolysis should be monitored.

During or following a course of treatment with ciprofloxacin bacteria that demonstrate resistance to ciprofloxacin may be isolated, with or without a clinically apparent superinfection. There may be a particular risk of selecting for ciprofloxacin-resistant bacteria during extended durations of treatment and when treating nosocomial infections and/or infections caused by Staphylococcus and Pseudomonas species.

Ciprofloxacin inhibits CYP1A2 and thus may cause increased serum concentration of concomitantly administered substances metabolised by this enzyme (e. g. theophylline, clozapine, olanzapine, ropinirole, tizanidine, duloxetine, agomelatine). Therefore, patients taking these substances concomitantly with ciprofloxacin should be monitored closely for clinical signs of overdose, and determination of serum concentrations (e. g. of theophylline) may be necessary (see section 4.5). Co-administration of ciprofloxacin and tizanidine is contra-indicated.

The concomitant use of ciprofloxacin with methotrexate is not recommended (see section 4.5).

Interaction with tests

The in-vitro activity of ciprofloxacin against Mycobacterium tuberculosis might give false negative bacteriological test results in specimens from patients currently taking ciprofloxacin.

4.5 Interaction with other medicinal products and other forms of interaction

Effects of other products on ciprofloxacin:

Drugs known to prolong QT interval

Ciprofloxacin, like other fluoroquinolones, should be used with caution in patients receiving drugs known to prolong QT interval (e. g. Class IA and III anti-arrhythmics, tricyclic antidepressants, macrolides, antipsychotics) (see section 4.4).

Chelation Complex Formation

The simultaneous administration of ciprofloxacin (oral) and multivalent cation-containing drugs and mineral supplements (e. g. calcium, magnesium, aluminium, iron), polymeric phosphate binders (e. g. sevelamer or lanthanum carbonate), sucralfate or antacids, and highly buffered drugs (e. g. didanosine tablets) containing magnesium, aluminium, or calcium reduces the absorption of ciprofloxacin. Consequently, ciprofloxacin should be administered either 1-2 hours before or at least 4 hours after these preparations. The restriction does not apply to antacids belonging to the class of H2 receptor blockers.

Food and Dairy Products

Dietary calcium as part of a meal does not significantly affect absorption. However, the concurrent administration of dairy products or mineral-fortified drinks alone (e. g. milk, yoghurt, calcium-fortified orange juice) with ciprofloxacin should be avoided because absorption of ciprofloxacin may be reduced.

Probenecid interferes with renal secretion of ciprofloxacin. Co-administration of probenecid and ciprofloxacin increases ciprofloxacin serum concentrations.

Metoclopramide accelerates the absorption of ciprofloxacin (oral) resulting in a shorter time to reach maximum plasma concentrations. No effect was seen on the bioavailability of ciprofloxacin.

Concomitant administration of ciprofloxacin and omeprazole containing medicinal products results in a slight reduction of C max and AUC of ciprofloxacin.

Effects of ciprofloxacin on other medicinal products:

Tizanidine must not be administered together with ciprofloxacin (see section 4.3). In a clinical study with healthy subjects, there was an increase in serum tizanidine concentration (C max increase: 7-fold, range: 4 to 21-fold; AUC increase: 10-fold, range: 6 to 24-fold) when given concomitantly with ciprofloxacin. Increased serum tizanidine concentration is associated with a potentiated hypotensive and sedative effect.

Renal tubular transport of methotrexate may be inhibited by concomitant administration of ciprofloxacin, potentially leading to increased plasma levels of methotrexate and increased risk of methotrexate-associated toxic reactions. The concomitant use is not recommended (see section 4.4).

Concurrent administration of ciprofloxacin and theophylline can cause an undesirable increase in serum theophylline concentration. This can lead to theophylline-induced side effects that may rarely be life threatening or fatal. During the combination, serum theophylline concentrations should be checked and the theophylline dose reduced as necessary (see section 4.4).

Other xanthine derivatives

On concurrent administration of ciprofloxacin and caffeine or pentoxifylline (oxpentifylline), raised serum concentrations of these xanthine derivatives were reported.

Simultaneous administration of ciprofloxacin and phenytoin may result in increased or reduced serum levels of phenytoin such that monitoring of drug levels is recommended.

A transient rise in the concentration of serum creatinine was observed when ciprofloxacin and cyclosporin containing medicinal products were administered simultaneously. Therefore, it is frequently (twice a week) necessary to control the serum creatinine concentrations in these patients.

Vitamin K antagonists

Simultaneous administration of ciprofloxacin with a vitamin K antagonist may augment its anti-coagulant effects. The risk may vary with the underlying infection, age and general status of the patient so that the contribution of ciprofloxacin to the increase in INR (international normalised ratio) is difficult to assess. The INR should be monitored frequently during and shortly after co-administration of ciprofloxacin with a vitamin K antagonist (e. g. warfarin, acenocoumarol, phenprocoumon, or fluindione).

In clinical studies, it was demonstrated that concomitant use of duloxetine with strong inhibitors of the CYP450 1A2 isozyme such as fluvoxamine, may result in an increase of AUC and C max of duloxetine. Although no clinical data are available on a possible interaction with ciprofloxacin, similar effects can be expected upon concomitant administration (see section 4.4).

It was shown in a clinical study that concomitant use of ropinirole with ciprofloxacin, a moderate inhibitor of the CYP450 1A2 isozyme, results in an increase of C max and AUC of ropinirole by 60% and 84%, respectively. Monitoring of ropinirole-related side effects and dose adjustment as appropriate is recommended during and shortly after co-administration with ciprofloxacin (see section 4.4).

It was demonstrated in healthy subjects that concomitant use of lidocaine containing medicinal products with ciprofloxacin, a moderate inhibitor of CYP450 1A2 isozyme, reduces clearance of intravenous lidocaine by 22%. Although lidocaine treatment was well tolerated, a possible interaction with ciprofloxacin associated with side effects may occur upon concomitant administration.

Following concomitant administration of 250 mg ciprofloxacin with clozapine for 7 days, serum concentrations of clozapine and N-desmethylclozapine were increased by 29% and 31%, respectively. Clinical surveillance and appropriate adjustment of clozapine dosage during and shortly after co-administration with ciprofloxacin are advised (see section 4.4).

C max and AUC of sildenafil were increased approximately twofold in healthy subjects after an oral dose of 50 mg given concomitantly with 500 mg ciprofloxacin. Therefore, caution should be used prescribing ciprofloxacin concomitantly with sildenafil taking into consideration the risks and the benefits.

In clinical studies, it was demonstrated that fluvoxamine, as a strong inhibitor of the CYP450 1A2 isoenzyme, markedly inhibits the metabolism of agomelatine resulting in a 60-fold increase of agomelatine exposure. Although no clinical data are available for a possible interaction with ciprofloxacin, a moderate inhibitor of CYP450 1A2, similar effects can be expected upon concomitant administration (see 'Cytochrome P450' in section 4.4).

Co-administration of ciprofloxacin may increase blood levels of zolpidem, concurrent use is not recommended.

4.6 Pregnancy and lactation

The data that are available on administration of ciprofloxacin to pregnant women indicates no malformative or feto/neonatal toxicity of ciprofloxacin. Animal studies do not indicate direct or indirect harmful effects with respect to reproductive toxicity. In juvenile and prenatal animals exposed to quinolones, effects on immature cartilage have been observed, thus, it cannot be excluded that the drug could cause damage to articular cartilage in the human immature organism / foetus (see section 5.3).

As a precautionary measure, it is preferable to avoid the use of ciprofloxacin during pregnancy.

Ciprofloxacin is excreted in breast milk. Due to the potential risk of articular damage, ciprofloxacin should not be used during breast-feeding.

4.7 Effects on ability to drive and use machines

Due to its neurological effects, ciprofloxacin may affect reaction time. Thus, the ability to drive or to operate machinery may be impaired.

4.8 Undesirable effects

The most commonly reported adverse drug reactions (ADRs) are nausea and diarrhoea.

ADRs derived from clinical studies and post-marketing surveillance with Ciproxin (oral, intravenous, and sequential therapy) sorted by categories of frequency are listed below. The frequency analysis takes into account data from both oral and intravenous administration of ciprofloxacin.

System Organ Class

International normalised ratio increased (in patients treated with Vitamin K antagonists)

The incidence of arthropathy (arthralgia, arthritis), mentioned above, is referring to data collected in studies with adults. In children, arthropathy is reported to occur commonly (see section 4.4).

Reporting of suspected adverse reactions

Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme

An overdose of 12 g has been reported to lead to mild symptoms of toxicity. An acute overdose of 16 g has been reported to cause acute renal failure.

Symptoms in overdose consist of dizziness, tremor, headache, tiredness, seizures, hallucinations, confusion, abdominal discomfort, renal and hepatic impairment as well as crystalluria and haematuria. Reversible renal toxicity has been reported.

Apart from routine emergency measures, e. g. ventricular emptying followed by medical carbon, it is recommended to monitor renal function, including urinary pH and acidify, if required, to prevent crystalluria. Patients should be kept well hydrated. Calcium or magnesium containing antacids may theoretically reduce the absorption of ciprofloxacin in overdoses

Only a small quantity of ciprofloxacin (<10%) is eliminated by haemodialysis or peritoneal dialysis.

In the event of overdose, symptomatic treatment should be implemented. ECG monitoring should be undertaken, because of the possibility of QT interval prolongation.

5. Pharmacological properties

5.1 Pharmacodynamic properties

Pharmacotherapeutic group: Fluoroquinolones, ATC code: J01MA02

Mechanism of action:

As a fluoroquinolone antibacterial agent, the bactericidal action of ciprofloxacin results from the inhibition of both type II topoisomerase (DNA-gyrase) and topoisomerase IV, required for bacterial DNA replication, transcription, repair and recombination.

Pharmacokinetic/pharmacodynamic relationship relationship

Efficacy mainly depends on the relation between the maximum concentration in serum (C max ) and the minimum inhibitory concentration (MIC) of ciprofloxacin for a bacterial pathogen and the relation between the area under the curve (AUC) and the MIC.

Mechanism of resistance

In-vitro resistance to ciprofloxacin can be acquired through a stepwise process by target site mutations in both DNA gyrase and topoisomerase IV. The degree of cross-resistance between ciprofloxacin and other fluoroquinolones that results is variable. Single mutations may not result in clinical resistance, but multiple mutations generally result in clinical resistance to many or all active substances within the class.

Impermeability and/or active substance efflux pump mechanisms of resistance may have a variable effect on susceptibility to fluoroquinolones, which depends on the physiochemical properties of the various active substances within the class and the affinity of transport systems for each active substance. All in-vitro mechanisms of resistance are commonly observed in clinical isolates. Resistance mechanisms that inactivate other antibiotics such as permeation barriers (common in Pseudomonas aeruginosa ) and efflux mechanisms may affect susceptibility to ciprofloxacin.

Plasmid-mediated resistance encoded by qnr-genes has been reported.

Spectrum of antibacterial activity

Breakpoints separate susceptible strains from strains with intermediate susceptibility and the latter from resistant strains:

1 Staphylococcus spp. - breakpoints for ciprofloxacin relate to high dose therapy.

* Non-species-related breakpoints have been determined mainly on the basis of PK/PD data and are independent of MIC distributions of specific species. They are for use only for species that have not been given a species-specific breakpoint and not for those species where susceptibility testing is not recommended.

The prevalence of acquired resistance may vary geographically and with time for selected species and local information on resistance is desirable, particularly when treating severe infections. As necessary, expert advice should be sought when the local prevalence of resistance is such that the utility of the agent in at least some types of infections is questionable.

Groupings of relevant species according to ciprofloxacin susceptibility (for Streptococcus species see section 4.4).

COMMONLY SUSCEPTIBLE SPECIES

Aerobic Gram-positive micro-organisms

Bacillus anthracis (1)

Aerobic Gram-negative micro-organisms

SPECIES FOR WHICH ACQUIRED RESISTANCE MAY BE A PROBLEM

Aerobic Gram-positive micro-organisms

Staphylococcus spp. * (2)

Aerobic Gram-negative micro-organisms

INHERENTLY RESISTANT ORGANISMS

Aerobic Gram-positive micro-organisms

Aerobic Gram-negative micro-organisms

Excepted as listed above

* Clinical efficacy has been demonstrated for susceptible isolates in approved clinical indications

+ Resistance rate ≥ 50% in one or more EU countries

($): Natural intermediate susceptibility in the absence of acquired mechanism of resistance

(1): Studies have been conducted in experimental animal infections due to inhalations of Bacillus anthracis spores; these studies reveal that antibiotics starting early after exposition avoid the occurrence of the disease if the treatment is made up to the decrease of the number of spores in the organism under the infective dose. The recommended use in human subjects is based primarily on in-vitro susceptibility and on animal experimental data together with limited human data. Two-month treatment duration in adults with oral ciprofloxacin given at the following dose, 500 mg bid, is considered as effective to prevent anthrax infection in humans. The treating physician should refer to national and/or international consensus documents regarding treatment of anthrax.

(2): Methicillin-resistant S. aureus very commonly express co-resistance to fluoroquinolones. The rate of resistance to methicillin is around 20 to 50% among all staphylococcal species and is usually higher in nosocomial isolates.

5.2 Pharmacokinetic properties

Following oral administration of single doses of 250 mg, 500 mg, and 750 mg of ciprofloxacin tablets, ciprofloxacin is absorbed rapidly and extensively, mainly from the small intestine, reaching maximum serum concentrations 1-2 hours later.

Single doses of 100-750 mg produced dose-dependent maximum serum concentrations (C max ) between 0.56 and 3.7 mg/L. Serum concentrations increase proportionately with doses up to 1000 mg.

The absolute bioavailability is approximately 70-80%.

A 500 mg oral dose given every 12 hours has been shown to produce an area under the serum concentration-time curve (AUC) equivalent to that produced by an intravenous infusion of 400 mg ciprofloxacin given over 60 minutes every 12 hours.

Protein binding of ciprofloxacin is low (20-30%). Ciprofloxacin is present in plasma largely in a non-ionised form and has a large steady state distribution volume of 2-3 L/kg body weight. Ciprofloxacin reaches high concentrations in a variety of tissues such as lung (epithelial fluid, alveolar macrophages, biopsy tissue), sinuses, inflamed lesions (cantharides blister fluid), and the urogenital tract (urine, prostate, endometrium) where total concentrations exceeding those of plasma concentrations are reached.

Low concentrations of four metabolites have been reported, which were identified as: desethyleneciprofloxacin (M 1), sulphociprofloxacin (M 2), oxociprofloxacin (M 3) and formylciprofloxacin (M 4). The metabolites display in-vitro antimicrobial activity but to a lower degree than the parent compound.

Ciprofloxacin is known to be a moderate inhibitor of the CYP 450 1A2 iso-enzymes.

Ciprofloxacin is largely excreted unchanged both renally and, to a smaller extent, faecally. The serum elimination half-life in subjects with normal renal function is approximately 4-7 hours.

Excretion of ciprofloxacin (% of dose)

Renal clearance is between 180-300 mL/kg/h and the total body clearance is between 480-600 mL/kg/h. Ciprofloxacin undergoes both glomerular filtration and tubular secretion. Severely impaired renal function leads to increased half lives of ciprofloxacin of up to 12 h.

Non-renal clearance of ciprofloxacin is mainly due to active trans-intestinal secretion and metabolism. 1% of the dose is excreted via the biliary route. Ciprofloxacin is present in the bile in high concentrations.

The pharmacokinetic data in paediatric patients are limited.

In a study in children C max and AUC were not age-dependent (above one year of age). No notable increase in C max and AUC upon multiple dosing (10 mg/kg three times daily) was observed.

In 10 children with severe sepsis C max was 6.1 mg/L (range 4.6-8.3 mg/L) after a 1-hour intravenous infusion of 10 mg/kg in children aged less than 1 year compared to 7.2 mg/L (range 4.7-11.8 mg/L) for children between 1 and 5 years of age. The AUC values were 17.4 mg*h/L (range 11.8-32.0 mg*h/L) and 16.5 mg*h/L (range 11.0-23.8 mg*h/L) in the respective age groups.

These values are within the range reported for adults at therapeutic doses. Based on population pharmacokinetic analysis of paediatric patients with various infections, the predicted mean half-life in children is approx. 4-5 hours and the bioavailability of the oral suspension ranges from 50 to 80%.

5.3 Preclinical safety data

Non-clinical data reveal no special hazards for humans based on conventional studies of single dose toxicity, repeated dose toxicity, carcinogenic potential, or toxicity to reproduction.

Like a number of other quinolones, ciprofloxacin is phototoxic in animals at clinically relevant exposure levels. Data on photomutagenicity/ photocarcinogenicity show a weak photomutagenic or phototumorigenic effect of ciprofloxacin in-vitro and in animal experiments. This effect was comparable to that of other gyrase inhibitors.

As reported for other gyrase inhibitors, ciprofloxacin causes damage to the large weight-bearing joints in immature animals. The extent of the cartilage damage varies according to age, species and dose; the damage can be reduced by taking the weight off the joints. Studies with mature animals (rat, dog) revealed no evidence of cartilage lesions. In a study in young beagle dogs, ciprofloxacin caused severe articular changes at therapeutic doses after two weeks of treatment, which were still observed after 5 months.

6. Pharmaceutical particulars

6.1 List of excipients

Bayer plc

Buy Allergies - Iremofar (Brand Name Atarax) Online - Order Hydroxyzine - Purchase Allergies - Iremo

Common use Atarax has a sedative and anxiolitic effect. It is an antihistamine with anticholinergic and sedative properties used to treat allergy. It positively affects cognitive abilities, improves memory and attention. The medication does not cause psychological dependence and addiction. It relaxes smooth muscles, has a bronchodilator and analgetic effect as well as moderately inhibits gastric secretion, it may be used as antiemetic and myorelaxant. Hydroxyzine reduces itching from hives, eczema, dermatitis, etc. After ingestion Hydroxyzine is converted to its active form named cetirizine (Zyrtec). Both hydroxyzine and cetirizine act as antihistamines.

Dosage and direction

A whole daily dosage of 25-100 mg for adults should be divided into several intakes in general practice, in psychiatry daily dose may be tripled. Usual duration of treatment is four weeks. Volume of the dosage should be diminished for aged persons and also in cases of kidney or liver failure. Do not use this drug unless it was prescribed by your doctor.

Precautions If such side effects like drowsiness and weakness do not disappear after several days of treatment, the dosage of Hydroxyzine should be reduced. Avoid simultaneous intake with MAO inhibitors. It is cautiously prescribed for patients subjected to arrhythmia or taking anti-arrhythmic medications as well for patients predisposed to convulsions, sick with narrow-angle glaucoma, prostatic hypertrophy, hyperthyroidism. Avoid drinking alcohol during the period of treatment with Hydroxyzine. Drivers and employers whose duties demand high concentration of attention should take the medication carefully in the process of their work.

Hypersensitivity, including one to cetirizine, aminophylline or ethylenediamine; porphyria; porphiria, pregnancy, during labor and delivery, breast-feeding.

Possible side effect

Emergency medical help is required if any of these signs of an allergy are found: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. The medication intake should interrupted. Other side effects may include: sedation, tiredness, sleepiness, dizziness, disturbed coordination, drying and thickening of oral and other respiratory secretions, and stomach distress, confusion, nervousness, irritability, blurred vision, double vision, tremor, loss of appetite, nausea.

Drug interaction Hydroxyzine strengthens the sedating effect on central nervous system of alcohol and other drugs that can cause sedation such as the benzodiazepine class of anti-anxiety drugs (Valium, Ativan, Klonopin, Xanax) or drugs which belong to narcotic class of pain medications (Percocet, Vicodin, Dilaudid) and others. Hydroxyzine can also intensify the drying effects of other medications with anticholinergic properties so the dose of Hydorxyzine should be reduced.

Never take a double dose of this medication. If it is almost time of the next dose just skip the missed portion and continue to take the medicine according to the schedule.

Overdose Hypersedation, tremor, convulsions, spasms, hallucinations, delirium, confusion, hypotension, nausea, vomit. General treatment includes induction of vomit (in absence of spontaneous one), gastric lavage, monitoring of vital body functions. Immediate medical attention is needed.

Storage Store at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture, kids and pets. Do not use after expiration term. Keep prepared suspension in a refrigerator during 14 days but do not freeze it, throw away after the term.

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Chefzone - 359 Photos & 64 Reviews - Wholesale Stores - 2888 Ualena St, Honolulu, Hi - Phone Number

ChefZone

ChefZone. (4 stars).

ChefZone is located near the Honolulu International Airport. It is owned by Y. Hata & Co. Ltd.

Membership is required… Read More

ChefZone. (4 stars).

ChefZone is located near the Honolulu International Airport. It is owned by Y. Hata & Co. Ltd.

Membership is required (and at some point ChefZone will have a membership FEE) but for right now all you need to do is sign up and you get a card right there. Don't lose your card though, because if you do, you will be charged $5!!

I love the 3 GALLON TUBS OF DAVE'S HAWAIIAN ICE CREAM. So cheap (cheaper than the Dave's Ice Cream Factory in Pearl City!!). Call ahead to find out what flavors ChefZone has in stock!

I really like the Asian foods aisle at ChefZone! They have a ginormous tub of Sambal Olek (chili garlic sauce) and potato starch (which is really the best for deep frying!!).

There is a kitchen supply area with very useful items that a restaurant and/or home chef/cook could use. Lots of gadgets and baking items as well.

I like the huge selection of flour tortillas that ChefZone has in stock. Tomato and Spinach and a few others. The tortillas come in all different sizes too!!

I'm not a fan of bubble tea but ChefZone does have an extensive array or flavors.

I am however a huge coffee drinker and ChefZone even sells the flavored syrups so I don't have to pay 50? a shot!!

One place I really enjoy going to is the ChillZone. ChefZone even supplies coats so that you don't freeze in there. My favorite thing to get is the fresh vegetables (mushrooms, bok choy, cilantro, etc). ChefZone has a huge selection of fresh vegetables (much more assortment than Costco) and most of the vegetable items are cheaper than Costco. ChillZone is my favorite part of ChefZone hands down!!

There is an aisle filled with restaurant sized seasoning and herbs. I love this aisle. I can find everything I need and it is so much cheaper than buying it from the super market and there are way more varieties of seasoning and herbs here vice Costco. Huge bottles of food coloring too!!

All in all when compared to Costco there are some definite pros to ChefZone! But for the meats and shellfish I would still stick to Costco.

Being that I like to cook, ChefZone is a convenient place to go to find some items that you might not find in Costco or Sam's. The people… Read More

Being that I like to cook, ChefZone is a convenient place to go to find some items that you might not find in Costco or Sam's. The people are friendly and there are lots of parking. Plus, it is very close to where I work and live so that makes it even more attractive to me. No fighting people for parking spaces like Costco, lol! Although some of the products are in bulk pack like Costco, I see that they are slowly making smaller packages in which people can consume in a more timely matter.

First review after a few months hiatus. It's been a busy 2 months with my 2nd oldest son graduating from high school and having family in… Read More

First review after a few months hiatus. It's been a busy 2 months with my 2nd oldest son graduating from high school and having family in town. And before we send him off to college, of course, there has to be a graduation party.

I really was on a tight budget and needed to buy things for his party in bulk. My sister has a membership with all the other major Wholesale Supplier, but she wouldn't always be available to take me. Well on this specific day she was and we realized that the "other" wholesale supplier didn't have frozen spinach. YUP! No frozen spinach. Popeye wouldn't have been happy.

So in our pursuit to find bulk frozen spinach, she took a chance and brought me here, Chef zone (where she also had a membership).

Located near Keehi Lagoon Drive, it was a very simple drive to this location. No traffic, lots of SHADED parking. When we entered, there was a counter with two workers that check your membership card. I was able to get in as my sister's guest. But they asked me if I wanted to sign up for a FREE MEMBERSHIP so I did. Now I wouldn't have to wait for my sister to be available to take me here. Cool deals!

This warehouse is similar to the other wholesale suppliers but smaller. No TV's, No jewelry, no mattresses, no tires, no electronics, no clothes, no furniture. This place was strictly just food and catering needs. It was perfect for what I needed.

They have an enormous walk in refrigerator that housed everything from fruit and veggies to meat, sauces, noodles, etc. Pretty much everything you would see in a refrigerator. I did realize that they didn't have any eggs or milk here though. I could've overlooked it but i don't recall seeing any. But the coolest thing is they have thick jackets hanging on a coat rack before the refrigerator entrance. Of course everyone's using it so if you don't feel comfortable sharing jackets with everyone else, bring your own or suck it up and go all in!

Chef Zone also has a huge selection of oriental/asian selections in bulk. Along with paper goods, mixed drink flavors, gallons and gallons of oil, mayonnaise, and even ketchup. I came to the conclusion that this place was not a Wholesale Supplier for someone just throwing a part. They supply restaurants with high volume. Because if you don't need 3 gallon of ketchup, best to just get a small bottle elsewhere.

Did they have frozen spinach? Yes indeed! Was it in bulk! Uh huh! Was I happy? Ya betcha! (Yes of course I bought other things for the party)

The staff was helpful, the prices are comparable, and the location was perfect. Wish they had better hours but oh well, it'll do for now. Definitely a fan of this place.

You need to sign for a membership card which is free, there is a fee for a lost card. They will check if you have a card when you enter the… Read More

You need to sign for a membership card which is free, there is a fee for a lost card. They will check if you have a card when you enter the store.

This store is HUGE! They have everything you need for a party, from paper goods, cooking ware, lots of vegetables, items sold in bulk.

I made my visit this time around because I heard from my friends they sell lady finger cookies, and my friends knew I been looking at most major stores and gourmet stores. I was happy to had found! They had lots on the shelf so I took what I needed and didn't shop for anything els since they were getting ready to close. People told me to order the lady finger cookies on line, but I didn't want to pay extra for shipping, and didn't want to receive the cookies broken. I was able to make a big batch of chocolate tiramisu for Christmas, thanks to Chef Zone and the variety of unique products.

Sadly, the cashiers were usually quite unhappy each time I went. They don't even greet you, or tell you thank you.

As for parking, there are lots and close to the door entrance

Oh ChefZone, where do I even begin.

Ok first of all, this is the place to go if your Costco card has expired, you don't want to pay for… Read More

Oh ChefZone, where do I even begin.

Ok first of all, this is the place to go if your Costco card has expired, you don't want to pay for membership fees, you rather dislike crazy crowded parking lots (cough *Costco cough) and the flock of people swarming aisles hovering to get free samples. If you are looking to buy in bulk or feigning for chef sized cooking proportions and quality goods, ChefZone is the place to go.

In the Chill Zone you'll find a big selection of meats and produce which is always very fresh. It's pretty cold in here as the name suggests, but wouldn't you rather have your food crisp and fresh than lukewarm and spoiled? Yeah that's what I thought. Take your time as you browse and walk through the aisles. There's everything from asian foods, bubble drink mixes, baking ingredients and much much more.

Look for the red backdrop and white chef hat to find their parking lot which has many stalls.

This is the hidden gem of Ualena street. There's only one thing I would recommend, those free samples. ChefZone how do we make this happen.

I stopped by Chefzone to kill time. It's just like Sam's Club or Costco, but strictly focuses on the restaurant industry. They have bulk… Read More

I stopped by Chefzone to kill time. It's just like Sam's Club or Costco, but strictly focuses on the restaurant industry. They have bulk food items to buy and restaurant equipment, (ex. baking pans, utensils, condiment bottles/holders, spatulas, glasses, mixing containers, etc.) It's pretty cool, I found myself wanting to purchase items to make my home more "restauranty"

The ChillZone. I don't care if I sound like a panty. But I needed to use the jackets they place near the entrance of the refrigerated section. Yes, the thought of using a "community" jacket did cross my mind but it was either use it or freeze my booty. I saw grown manly men walk in with no jacket and come right back out and grab a jacket. So that shows how cold it was in there.

The prices for some of the bulk food items were a little high compared to Sam's club/Costco. I also saw some buckets of chocolate, caramel, etc. Makes me wonder how many places uses these items and say it's made "in-house"

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Jan K.

ChefZone. (4 stars).

ChefZone is located near the Honolulu International Airport. It is owned by Y. Hata & Co. Ltd.

Membership is required (and at some point ChefZone will have a membership FEE) but for right now all you need to do is sign up and you get a card right there. Don't lose your card though, because if you do, you will be charged $5!!

I love the 3 GALLON TUBS OF DAVE'S HAWAIIAN ICE CREAM. So cheap (cheaper than the Dave's Ice Cream Factory in Pearl City!!). Call ahead to find out what flavors ChefZone has in stock!

I really like the Asian foods aisle at ChefZone! They have a ginormous tub of Sambal Olek (chili garlic sauce) and potato starch (which is really the best for deep frying!!).

There is a kitchen supply area with very useful items that a restaurant and/or home chef/cook could use. Lots of gadgets and baking items as well.

I like the huge selection of flour tortillas that ChefZone has in stock. Tomato and Spinach and a few others. The tortillas come in all different sizes too!!

I'm not a fan of bubble tea but ChefZone does have an extensive array or flavors.

I am however a huge coffee drinker and ChefZone even sells the flavored syrups so I don't have to pay 50? a shot!!

One place I really enjoy going to is the ChillZone. ChefZone even supplies coats so that you don't freeze in there. My favorite thing to get is the fresh vegetables (mushrooms, bok choy, cilantro, etc). ChefZone has a huge selection of fresh vegetables (much more assortment than Costco) and most of the vegetable items are cheaper than Costco. ChillZone is my favorite part of ChefZone hands down!!

There is an aisle filled with restaurant sized seasoning and herbs. I love this aisle. I can find everything I need and it is so much cheaper than buying it from the super market and there are way more varieties of seasoning and herbs here vice Costco. Huge bottles of food coloring too!!

All in all when compared to Costco there are some definite pros to ChefZone! But for the meats and shellfish I would still stick to Costco.

George H.

Chef zone is a interesting place. They have a pretty nifty assortment of items and for the most part the staff is pretty nice and helpful.

What really kills it however is their terrible stock levels. I'm not sure how they gear this towards businesses but they run out of items all the time. I've once went in 4 days in a row and they didn't have mint and other items I look for in stock.

Beyond that basic items such as sugar and milk all cost more the Costco so I'm not sure where the advantage of coming here is.

Anita C.

We like coming here to get our jumbo sized caramel syrup for our coffee and some fresh veggies. This place is kinda like Costco/Sams Club, but a smaller version. Except for their walk in cooler. That's huge! Oh and if you want to go in the cooler, wear pants and bring a jacket. It's really cold. There are jackets that they provide outside the 2 entrances/exits to the cooler, but I don't like using them cause everyone else does. Anyways, there are some stuff that you can find at the other places that are cheaper, but this place has somethings that you find are cheaper that you can't find elsewhere. One thing to remember is that the prices on the placard are by UOM (unit of measure). Some actually show the UOM on the placard and the sticker on the item shows the weight. I almost fell over when the guy restocking inside the cooler told me the weight is on the sticker and the cost for the UOM is on the placard! Before he said anything I thought "dang! $20 for that big thing of pork butt was an awesome deal!" Hahaha yeah right. That was 20 lbs at $2.97/lb! Go ahead. Figure that out. Ok that's a good price, but I didn't realize that was 20 LBS worth. Wifey was cracking up all the way out of the cooler. The veggies are pretty fresh and found out they have a big bag of luau leaves and a slightly smaller bag (about half the size) for reasonable prices. Sorry. Forgot to write the prices down. Anyways, can't wait for the next time I make laulau. Everyone there are friendly and helpful if you're looking down every aisle like a lost kid. I jus wish their prices were a little more reasonable for the items that are also found in the club stores.

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Example: There are a few times in life when a meal is so expertly crafted and planned that it is nothing short of genius. Last night, I had one of those meals - the Mahi Mahi.

The dish was excellently prepared. Grilled, juicy, and fresh without a hint of fishiness. A glaze of tangerine sauce brought a hint of tart sweetness. The fish was placed on a mound of sweet plantain rice. The combination of the fish and rice alone was to die for!

However, as only expert chefs can achieve, additional garnishes provided even bolder, beautiful tastes. Pickled onions topping the fish made for an even finer taste experience, while green beans hidden under the fish added freshness and completed each bite

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Norbactin, Norbactin

Norbactin

Important Notice: The Drugs. com international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

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Ruduo skaiciuoja dar tik pirmasias dienas, taciau peršalimo ligos pradeda savo plitimo sezona. Permainingas rudeninis oras bei nepakankamas rupinimasis savo ir šeimos nariu sveikata daznai nulemia viena nemaloniausiu bei sunkiausiai prognozuojamu sveikatos sutrikimu – gerkles skausma. „Dazniausiai gerkles skausmo sukelejai yra virusai, kurie pazeidzia gerkles gleivine. Uzklupus virusiniam gerkles uzdegimui peršti, skauda gerkle, juntamas burnos sausumas, kosejama ar ciaudejama, vargina sloga, neretai uzkimstama, šiek tiek pakyla temperatura.

Buvo manoma, kad gyvunams tapus socialesniais, jie tuo paciu pradejo keistis ir ivairiomis infekcijomis, todel išaugo stiprios imunines sistemos poreikis. Mokslininkai iš Virdzinijos universiteto pirma karta irode, kad imunine sistema tiesiogiai reguliuoja smegenu dali, atsakinga uz socialini elgesi. Tai reiškia, kad iš tiesu gyvunu evoliucijos procese viskas vyko atvirkšciai, nei manyta. Zurnale „Nature“ aprašytas tyrimas su grauzikais. Mokslininkai pastebejo, kad peles, kurios neturejo imunines molekules – interferono gama (IFN-γ), buvo maziau socialios ir net turejo polinki i autizma.

Lietuva pradeda bendradarbiavima su Japonijos medicinos tyrimu agentura AMED. Tai buvo sutarta susitikimo Sveikatos apsaugos ministerijoje metu, kuomet sveikatos apsaugos viceministras Valentinas Gavrilovas susitiko su Japonijos delegacija, vadovaujama dr. Makoto Suematsu.

Vyrai kile iš Marso, moterys – iš Veneros. Vieniems šis posakis gali pasirodyti visiškai neteisingas, tuo tarpu kiti mano – „tiesiai i dešimtuka“. Visgi šis posakis tikrai turi pagrindo, ypac kalbant apie svorio metima. Moterims kur kas sunkiau nei vyrams numesti nepageidaujama svori del ivairiu priezasciu. Kartais tai rodosi visiškai neteisinga. Atrodo, jog moterims uztenka zvilgtelti i skanu deserta, ir šlaunys bei klubai savaime paplateja. Tuo tarpu vyrai, tik nezymiai sumazine maisto porciju dydi, pasiekia puikiu rezultatu. Priezastis, kodel moterims sunkiau numesti svorio nei vyrams, ivardija tinklarašcio apie mityba, sveika gyvensena ir sporta ikurejas ir autorius Arnas Slenys.

Ankstyvas senejimas yra viena didziausiu moteru baimiu. Saules spinduliai ir aplinkos tarša daro itaka musu odai, del to atsiranda pigmentines demes, raukšles ir kiti ankstyvo senejimo pozymiai. Puoseledamos grozi, visuomet labiau rupinames veido oda, o pamirštame kakla ir rankas. Tuo tarpu kaklas ir rankos yra tos vietos, kurios labiausiai atspindi musu amziu. Todel ju prieziurai reiketu skirti zymiai daugiau demesio. Tinklapis Econet pateikia efektyvias naturalias priemones, kurias galite pasigaminti pacios.

Ar esate sau uzdave klausima, koks jusu gyvenimo tikslas? Kokia apskritai gyvenimo ir Visatos prasme? Kas jus padaro laimingais? Meikas Wikingas, zinomas Danijos laimes guru ir knygu apie laime autorius, Laimes tyrinejimu instituto Danijoje direktorius, atskleidzia, ka iš tikruju reiškia buti laimingiems. „Hygge“ – štai kuo vadovaujasi danai. Taip vadinamas konceptas, kuris šiems zmonems padeda iškesti ilga ir tamsia ziema. O visa tai, kas slypi tame, suteikia ir itin daug dziaugsmo.

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Buy Gastrointestinal - Uro-Hytrin (Brand Name Hytrin) Online - Order Terazosin - Purchase Gastrointe

Hytrin is used for treating high blood pressure and treating signs and symptoms of benign prostatic hyperplasia (BPH). Hytrin is an alpha-blocker. It works by relaxing muscles in the blood vessels, resulting in lowering of blood pressure. In BPH, alpha-blockers work by relaxing muscles around the urethra (tube that drains urine from the bladder), which improves urinary symptoms.

Use Hytrin as directed by your doctor.

Take Hytrin by mouth with or without food.

Hytrin may cause a sudden drop in blood pressure after the first dose. Take your first dose at bedtime. If you get up during the night, sit up slowly, then stand slowly.

If you miss a dose of Hytrin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. If more than one dose is missed, contact your doctor or pharmacist.

Ask your health care provider any questions you may have about how to use Hytrin.

Store Hytrin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Hytrin out of the reach of children and away from pets.

Active Ingredient: Terazosin hydrochloride.

Do NOT use Hytrin if:

you are allergic to any ingredient in Hytrin or to similar medicines (eg, prazosin).

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Hytrin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have prostate cancer, angina pectoris, heart disease, or kidney or liver problems

if you will be having eye surgery.

Some medicines may interact with Hytrin. Tell your health care provider if you are taking any other medicines, especially any of the following:

Phosphodiesterase type 5 (PDE5) inhibitors (eg, sildenafil) or verapamil because severe dizziness, lightheadedness, or fainting may occur.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Hytrin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Hytrin may cause drowsiness, dizziness, blurred vision, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Hytrin with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Hytrin; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.

Hytrin may cause a sudden drop in blood pressure after the first dose. Take your first dose at bedtime. If you get up during the night, sit up slowly, then stand slowly. This will help to reduce your lightheadedness or dizziness. These effects are more likely to occur after the first few doses or if your dose has increased, but can occur at any time while you are taking the medicine. It can also occur if you stop taking the medicine and then restart treatment.

Hytrin may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.

Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.

Do NOT take more than the recommended dose without checking with your doctor.

Hytrin may rarely cause a prolonged, painful erection. This could happen even when you are not having sex. If this is not treated right away, it could lead to permanent sexual problems such as impotence. Contact your doctor right away if this happens.

Tell your doctor or dentist that you take Hytrin before you receive any medical or dental care, emergency care, or surgery (including eye surgery).

Lab tests, including blood pressure, may be performed while you use Hytrin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Hytrin should not be used in children; safety and effectiveness in children have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Hytrin while you are pregnant. It is not known if Hytrin is found in breast milk. If you are or will be breast-feeding while you use Hytrin, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Dizziness; drowsiness; lightheadedness; nasal congestion; nausea; weakness.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision or other vision changes; chest pain; decreased sexual desire or ability; fainting; fast, slow, or irregular heartbeat;painful, prolonged erection; severe or prolonged dizziness or headache; shortness of breath; swelling of the ankles, feet, or hands.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Teril (Carbamazepine) Drug, Teril

Teril

NOTICE: This Consumer Medicine Information (CMI) is intended for persons living in Australia. This page contains answers to some common questions about Teril. It does not contain all the information that is known about Teril. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risk of you using this medicine against the benefits he/she expects it will have for you. If you have any concerns about using this medicine, ask your doctor or pharmacist. Bookmark or print this page, you may need to read it again.

What Teril is used for

Teril is used to:

control epilepsy, a condition where you have repeated seizures (fits)

treat trigeminal neuralgia, where there are sudden, repeated attacks of facial pain

control mania, a mental condition with episodes of overactivity, elation or irritability

prevent bipolar mood disorder where periods of mania alternate with periods of depression.

Teril belongs to a group of medicines called anticonvulsants. These medicines are thought to work by controlling brain chemicals which send signals to nerves so that seizures do not happen. Teril also regulates other nerve functions in the body.

Teril may be used alone or in combination with other medicines to treat your condition.

Ask your doctor if you have any questions about why Teril has been prescribed for you.

Your doctor may have prescribed Teril for another reason.

Teril is available only with a doctor's prescription.

There is no evidence that Teril is addictive.

Before you take Teril

When you must not take it

Do not take Teril if you are allergic to:

any other medicine containing carbamazepine (e. g. Tegretol)

phenytoin (Dilantin) and oxcarbazepine (Trileptal), which are other medicines for epilepsy.

tricyclic antidepressants, medicines used to treat depression

any of the ingredients listed at the end of this leaflet.

Symptoms of an allergic reaction may include shortness of breath, wheezing or difficulty breathing; swelling of the face, lips, tongue or other parts of the body; rash, itching or hives on the skin.

Do not take Teril if you are currently taking a medicine called a monoamine oxidase inhibitor (MAOI), or have taken one in the last 14 days.

Taking Teril with a MAOI or within 14 days of taking a MAOI may cause a serious reaction with a sudden increase in body temperature, extremely high blood pressure and severe convulsions.

Do not take Teril within 14 days of stopping a MAOI.

Ask your doctor or pharmacist if you are not sure whether you are taking, or have been taking a MAOI medicine.

MAOIs are used to treat depression and Parkinson's disease. Some examples of MAOIs include phenelzine, tranylcypromine, selegiline.

Do not take Teril if you have, or have had, any of the following:

severe liver or heart disease

systemic lupus erythematosus (SLE)

bone marrow depression, a blood disease with a low platelet, red blood cell or white blood cell count

an irregular heartbeat caused by a condition called A-V block

hepatic porphyria, a disturbance in the production of porphyrin, a pigment important for liver function and blood formation.

Do not take this medicine after the expiry date printed on the pack or if the packaging is torn or shows signs of tampering.

If it has expired or is damaged, return it to your pharmacist for disposal.

If you are not sure whether you should start taking Teril, talk to your doctor or pharmacist.

Before you start to take it

Tell your doctor if you are allergic to any other medicines, foods, dyes or preservatives.

Tell your doctor if you are pregnant or plan to become pregnant.

Teril may affect your unborn baby during pregnancy and soon after birth. But it is still important that you control your fits while you are pregnant. Your doctor will discuss the risks and benefits of taking Teril during pregnancy and help you decide whether or not you should take Teril.

Tell your doctor if you are breastfeeding or wish to breastfeed.

Teril passes into breast milk but it is unlikely to affect your baby. You may breast-feed provided that you watch your baby for any signs of any unwanted side effect. If your baby develops a skin rash, becomes very sleepy or has other unusual symptoms, don't breast-feed again until you speak to your doctor. Your doctor will discuss the risks and benefits of taking Teril while breastfeeding.

Tell your doctor if you have, or have had, any medical conditions, especially the following:

increased pressure in the eye (glaucoma)

prostate problems or if you cannot retain your urine

blood disorders caused by other medicines

any mental disorder such as depression or schizophrenia.

Tell your doctor if you are of Asian descent, particularly if you are Chinese or Thai.

Your doctor may want to do a genetic test before you take Teril for the first time.

The risk of serious skin reactions in patients of Han Chinese or Thai origin associated with carbamazepine or chemically-related compounds may be predicted by testing a blood sample of these patients.

You doctor should be able to advise if a blood test is necessary before taking Teril.

If you have not told your doctor about any of the above, tell them before you start taking Teril.

Taking other medicines

Tell your doctor if you are taking any other medicines, including any that you buy without a prescription from a pharmacy, supermarket or health food shop.

Some medicines may be affected by Teril, or may affect how well it works. These include:

MAOI medicines. Teril must not be taken together with a MAOI or within 14 days of taking a MAOI

other medicines used to treat depression such as fluvoxamine, nefazodone, paroxetine, bupropion, citalopram, tricyclic antidepressants and trazodone

other medicines used to treat seizures including phenytoin, levetiracetam and oxcarbazepine

some medicines used to treat mental disorders such as clozapine, haloperidol, thioridazine, lithium, olanzapine, quetiapine, risperidone and ziprasidone

some medicines used to treat heart problems or high cholesterol

some medicines used to help you sleep or calm you down

some pain relievers such as paracetamol, dextro-propoxyphene, tramadol and ibuprofen

warfarin, a medicine used to prevent blood clots

some diuretics (fluid tablets), which are medicines used to reduce water retention and high blood pressure

some antibiotics and antifungal medicines used to treat infections, such as erythromycin, clarithromycin, doxycycline, itraconazole, ketoconazole, fluconazole, voriconazole and rifampicin

corticosteroids such as prednisolone and dexamethasone

St John's Wort, an ingredient in many medicines that you can buy without a prescription from a pharmacy, health food shop or supermarket.

antihistamines such as loratadine and terfenadine, which are medicines used to prevent or relieve the symptoms of allergies such as hay fever

isoniazid, a medicine used to prevent and treat tuberculosis

acetazolamide, a medicine used to reduce fluid retention and to treat glaucoma and some types of seizures

medicines used to treat stomach or duodenal ulcers, such as cimetidine and omeprazole

muscle relaxants such as dantrolene and oxybutynin

ticlopidine, a medicine used to prevent blood clotting

some medicines used to treat asthma, such as theophylline and aminophylline

some medicines used to prevent rejection of organ transplants and to treat severe rheumatoid arthritis and some skin diseases, such as cyclosporin and everolimus

some medicines used to treat cancer, such as cisplatin, doxorubicin and imatinib

methadone, a medicine used to

control severe pain and to treat heroin addiction

metoclopramide, a medicine used to treat nausea and vomiting

isotretinoin, a medicine used to treat acne

danazol, a medicine used to treat endometriosis

a vitamin called nicotinamide

muscle relaxants, which are medicines used during surgery

medicines used to treat HIV such as indinavir, ritonavir and saquinavir

levothyroxine, a medicine used to treat underactive thyroids

praziquantel, a medicine used to treat worm infections of the blood

medicines containing oestrogen and progesterone, including hormone replacement therapy and contraceptives.

The above medicines may be affected by Teril or they may affect how well it works. You may need to take different amounts of your medicines or you may need to take different medicines.

Tell your doctor if you are using hormonal contraceptive (e. g. birth control pill or injections).

If you are taking Teril while you are using hormonal contraceptives, they may not work as well as they should. Unplanned pregnancies can happen. Your doctor can suggest another form of birth control (non-hormonal) while you are taking Teril.

Tell your doctor immediately if you notice irregular vaginal bleeding or spotting.

If you are not sure whether you are taking any of these medicines, check with your doctor or pharmacist.

Your doctor and pharmacist have more information on medicines to be careful with or avoid while taking Teril.

How to take Teril

Follow all directions given to you by your doctor and pharmacist carefully.

They may differ from the information contained in this leaflet.

If you do not understand the instructions on the bottle, ask your doctor or pharmacist.

How much to take

Your doctor will tell you how much Teril you need to take each day. The dose varies from patient to patient and may depend on your age, medical condition and whether or not you are taking other medicines.

Your doctor will usually start you on a low dose and then gradually increase it depending on your condition and how you respond to this medicine.

How to take it

Swallow the tablets with a glass of water.

Teril tablets can be divided in half along the breakline, if advised by your doctor or pharmacist.

When to take it

Take Teril during or immediately after food.

This will lessen the chance of a stomach upset.

Take your medicine at about the same time each day, spaced evenly apart.

Taking it at the same time each day will have the best effect. It will also help you remember when to take it.

How long to take it for

Keep taking Teril for as long as your doctor recommends.

Teril helps to control your condition but does not cure it. You must take it regularly every day, even if you feel well.

Do not stop taking Teril or lower the dose without first checking with your doctor. Do not let yourself run out of medicine over the weekend or on holidays.

Stopping your medicine suddenly or lowering the dose may cause unwanted side effects or make your condition worse. If you are taking this medicine to treat epilepsy, you could develop seizures (fits). Your doctor will usually reduce the dose slowly before you can stop taking it completely.

If you forget to take it

If it is almost time for your next dose, skip the dose you missed and take your next dose when you are meant to.

Otherwise, take the missed dose as soon as you remember, and then go back to taking your tablets as you would normally.

Do not take a double dose to make up for the dose you missed.

If you are not sure what to do or have any questions, ask your doctor or pharmacist.

If you have trouble remembering when to take your medicine, ask your pharmacist for some hints.

If you take too much (overdose)

Immediately telephone your doctor or the Poisons Information Centre (telephone 13 11 26) for advice, or go to Accident and Emergency at the nearest hospital, if you think you or anyone else may have taken too much Teril. Do this even if there are no signs of discomfort or poisoning.

You may need urgent medical attention.

Keep the telephone numbers of these places handy.

Some of the symptoms of an overdose may include agitation, disorientation, drowsiness, fainting, vomiting, difficulty breathing, fast and irregular heartbeat, blurred vision, shakiness and slurred speech.

While you are taking Teril

Things you must do

Before starting any new medicine, tell your doctor or pharmacist that you are taking Teril.

Tell all the doctors, dentists and pharmacists who are treating you that you are taking Teril.

Tell your doctor, if for any reason, you have not taken your medicine exactly as prescribed.

Otherwise your doctor may change your treatment unnecessarily.

If you become pregnant while taking Teril, tell your doctor immediately.

Your doctor can discuss with you the risks of taking it while you are pregnant.

Tell your doctor immediately if at any time you have thought of harming or killing yourself.

A number of people being treated with antiepileptics have had such thoughts or behaviour. Patients and caregivers should be alert and monitor for these effects.

If you or someone you know is showing any of the following warning signs of suicide while taking Teril, contact your doctor or a mental health professional right away or go to the nearest hospital for treatment:

thoughts or talk of death or suicide

thoughts or talk of self-harm or harm to others

any recent attempts of self-harm

increase in aggressive behaviour, irritability, or any other unusual changes in behaviour or mood.

All mentions of suicide or violence must be taken seriously.

If you plan to have surgery, including dental surgery, tell your doctor or dentist that you are taking Teril.

This medicine may interfere with some of the medicines used during surgery.

Visit your doctor regularly so they can check on your progress.

To help prevent unwanted side effects from happening, your doctor may want to do some tests before you start taking Teril and from time to time during the course of your treatment. You may need to have tests to check your eyes, liver, kidneys or blood.

Things you must not do

Do not stop taking Teril, or lower the dose, without checking with your doctor.

Do not let yourself run out of medicine over the weekend or on holidays.

Stopping your medicine suddenly or lowering the dose may cause unwanted side effects or make your condition worse. Your doctor will usually reduce the dose slowly before you can stop taking it completely.

Do not use Teril to treat any other conditions unless your doctor tells you to.

Do not give Teril to anyone else, even if they have the same condition as you.

Things to be careful of

Be careful driving, operating machinery or doing jobs that require you to be alert until you know how Teril affects you. Children should avoid doing things like riding bicycles or climbing trees.

Teril may cause drowsiness, dizziness, blurred vision, double vision or lack of muscle coordination in some people, especially when you first start to use it or when the dose is increased.

Be careful drinking alcohol while taking Teril.

Combining Teril and alcohol can make you more drowsy or dizzy. Your doctor may suggest you avoid alcohol while you are being treated with Teril.

Be careful drinking grapefruit juice while taking Teril.

Taking Teril with grapefruit juice may increase the chances of side effects. Your doctor may suggest you avoid grapefruit juice while you are being treated with Teril.

If outdoors, wear protective clothing and use at least a SPF 30+ sunscreen. Do not use a sunlamp or tanning bed or booth.

Teril may cause your skin to be much more sensitive to sunlight than it normally is. Exposure to sunlight may cause a skin rash, itching, redness or severe sunburn. If your skin does appear to be burning, tell your doctor.

Side effects

Ask your doctor or pharmacist to answer any questions you may have.

Tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking Teril.

Like all other medicines, Teril may have unwanted side effects in some people. Sometimes they are serious, most of the time they are not. You may need medical treatment if you get some of the side effects.

If you are over 65 years of age, you may have an increased chance of getting side effects.

Do not be alarmed by this list of possible side effects.

You may not experience any of them.

Ask your doctor or pharmacist to answer any questions you may have.

Tell your doctor if you notice any of the following and they worry you:

dizziness or lightheadedness

feeling tired or drowsy

weakness, unsteadiness when walking

unusual secretion of breast milk

loss of muscle coordination.

The above list includes the more common side effects of Teril. They tend to be mild and short-lived.

Tell your doctor immediately or go to Accident and Emergency at the nearest hospital if you notice any of the following:

signs of allergy such as swelling of the face, lips, tongue or other parts of the body; wheezing or troubled breathing; difficult swallowing, itching, hives, chest discomfort or tightness, loss of consciousness

skin rash, redness, blisters or peeling skin, accompanied by fever, chills, headache, cough, body aches

sudden increase in body temperature, together with sweating, fast heart beat and muscle stiffness, altered consciousness, high blood pressure, excessive salivation

constant "flu-like" symptoms (chills, fever, sore throat, swollen glands, aching joints, lack of energy)

usual bleeding or bruising under the skin, nosebleeds

shortness of breath and dizziness when exercising

frequent infections such as fever

severe chills, sore throat, swollen glands or mouth ulcers

persistent nausea or vomiting, loss of appetite and feeling generally unwell, which may be accompanied by pain in the abdomen, fever, itching, a yellow colour to skin or eyes (jaundice), dark coloured urine or light coloured bowel motions

diarrhoea, abdominal pain and fever

severe upper stomach pain, often with loss of appetite and vomiting

more frequent or more severe seizures (fits)

sudden onset of uncontrollable muscle spasms affecting the eyes, head, neck and body

trembling, uncontrolled body movements

depression, aggressive behaviour, recurrence of a previous mental illness, hallucinations (hearing or seeing things that are not there)

swelling of the feet and legs or weight increase due to fluid build-up

changes in behaviour, weakness

change in heartbeat (slow, fast or irregular), sometimes with fainting or chest pain

passing less urine than normal, which may occur with lack of energy, vomiting, headache or confusion

blood in the urine

symptoms of sunburn such as redness, itching, swelling or blistering that may happen more quickly than normal

red blotchy rash mainly on the face which may be accompanied by fatigue, fever, nausea, loss of appetite

swelling or redness along a vein or nerve, which is extremely tender when touched

signs that blood clots may have formed, such as sudden severe headache, sudden loss of coordination or vision, pain in calves, thighs or chest

severe headache together with stiffness of the neck, muscle spasms and extreme sensitivity to bright light.

The above side effects are serious and require medical attention or even hospitalisation. These serious side effects are very rare.

Tell your doctor if you notice anything that is making you feel unwell.

Other side effects not listed above may also occur in some patients. Some of these side effects (e. g. changes in sodium levels, thyroid function, structure of bones, cholesterol level or blood pressure) can only be found when your doctor does tests from time to time to check your progress.

After taking Teril

Storage

Keep Teril where children cannot reach it.

A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.

Keep your medicine in the original container until it is time to take it.

Keep your tablets in a cool dry place where the temperature stays below 30°C.

Do not store Teril or any other medicine in the bathroom or near a sink.

Do not leave Teril in the car or on window sills.

Heat and dampness can destroy some medicines.

Disposal

If your doctor tells you to stop taking Teril, or your tablets have passed their expiry date, ask your pharmacist what to do with any that are left over.

Product description

What it looks like

Teril is a round, white, scored tablet marked "CB" over "200" on one side and "G" on the reverse.

Each bottle contains 200 tablets.

Ingredients

The active ingredient in Teril is carbamazepine. Each Teril tablet contains 200 mg of carbamazepine.

The tablets also contain the following inactive ingredients:

pregelatinised maize starch

sodium starch glycollate

Your #1 Choice For Boats For Sale In Maine, Doxymix

Your #1 Choice for Boats for Sale in Maine

Hamlin’s Marine wants you to enjoy every moment on the water.

For over twenty years Hamlin’s Marine has delivered on a simple promise… ”If you purchase a boat from Hamlin’s Marine, we’ll always be there when you need us.” Hamlin’s Marine offers convenience and assurance with our locations in Waterville and Hampden, staff of twenty-five dedicated employees, and a fleet of service trucks.

At Hamlin’s we only sell boats that we can stand behind. Our manufacturers include Bennington Pontoons. Stingray. Mastercraft. Cutwater. Northcoast. Puffin. Alumacraft. Achilles. Scout Boats. and Yamaha Outboards. These manufacturers lead the industry in quality construction, and make it easier to serve you when it matters most.

So come on in and choose from our selection of new and used Pontoon Boats, Tow Boats or any other fishing boats or family fun boats. With two easy locations in Waterville, Maine (Boat Sales and Service) or Hampden, Maine (Boat Sales, Service, and Marina) it couldn't get any more convenient. Choose Hamlin’s Marine as your boat dealer, service center, marina, and indoor storage facility, and we promise you’ll make wonderful memories on the water in Maine.

At Hamlin's Marine we stand behind all of our boats for sale in Maine .

Why Buy From Hamlin's Marine:

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Akorazol Drug & Pharmaceuticals, Akorazol

Medication: Akorazol

Akorazol - Broad spectrum antifungal agent used for long periods at high doses, especially in immunosuppressed patients.

Indication: For the treatment of the following systemic fungal infections: candidiasis, chronic mucocutaneous candidiasis, oral thrush, candiduria, blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis.

Akorazol, like clotrimazole, fluconazole, itraconazole, and miconazole, is an imidazole antifungal agent.

Pharmaceutical active ingredients containing related brand and generic drugs, medications or other health care products:

Akorazol available forms, composition, doses:

Cream; Topical; Ketoconazole 2%

Akorazol destination | category:

Human:

Antifungals

Azoles

Preparations for vaginal conditions

Psoriasis, seborrhea and ichthyosis preparations

Topical antifungals and antiparasites

Indications and usages, anatomical therapeutic chemical and diseases classification codes:

Pharmaceutical companies, researchers, developers, manufacturers, distributors and suppliers:

Reviews:

Dexcom™ Sts™ Continuous Glucose Monitoring System, Dexacom

DexCom™ STS™ Continuous Glucose Monitoring System - P050012

This is a brief overview of information related to FDA's approval to market this product. See the links below to the Summary of Safety and Effectiveness and product labeling for more complete information on this product, its indications for use, and the basis for FDA's approval.

What is it? The DexCom STS Continuous Glucose Monitoring System is a glucose sensor that reports glucose values every 5 minutes for up to 72 hours. These readings are used with fingerstick results to detect trends and patterns in glucose levels in adults with diabetes, age 18 and over.

How does it work? The sensor is inserted in the abdomen. After a 2 hour start-up period, the STS System is calibrated with 2 fingerstick measurements taken by a traditional glucose meter. After calibration, the STS System provides a glucose reading and updated glucose trend information for viewing every 5 minutes. The STS System also contains a built-in alarm that can be programmed to alert the user when results fall below pre-set low and pre-set high levels.

When is it used? The DexCom STS Continuous Glucose Monitoring System is used with fingerstick measurements to provide additional glucose information to adults with diabetes, age 18 and over, and their healthcare practitioners. The Indications for Use are:

The DexCom STS Continuous Glucose Monitoring System is a glucose-monitoring device indicated for detecting trends and tracking patterns in adults (age 18 and older) with diabetes. The DexCom STS System is intended for use by patients at home and in health care facilities. The device is for prescription use.

The DexCom STS Continuous Glucose Monitoring System is indicated for use as an adjunctive device to complement, not replace, information obtained from standard home glucose monitoring devices.

The DexCom STS Continuous Glucose Monitoring System aids in the detection of episodes of high blood glucose (hyperglycemia) and low blood glucose (hypoglycemia), facilitating both acute and long-term therapy adjustments, which may minimize these excursions. Interpretation of the STS System results should be based on the trends and patterns seen with several sequential Sensor readings over time.

What will it accomplish? Additional glucose information may help people with diabetes and their healthcare practitioners to better manage their disease by providing more information on glucose trends and patterns than can be obtained with fingerstick glucose measurements alone.

When should it not be used?

This device is not designed to replace a blood glucose meter. The DexCom STS System must be used with a blood glucose meter.

Treatment decisions should not be based solely on results from the DexCom STS System. You must confirm with a blood glucose meter before making therapeutic adjustments.

Symptoms related to low or high blood glucose levels should not be ignored. If you have symptoms of low or high glucose, use your blood glucose meter to check the STS System results.

You should update the STS System’s calibration every 12 hours at a minimum to ensure device performance. The performance of the STS System when calibrated less frequently than the recommended minimum of every 12 hours, has not been studied.

Other Resources

Rinobudex Kaufen - Rinobudex (Mometasone) Ohne Rezept, Rinobudex

Elocon Creme ist zur Behandlung von Juckreiz, Rotung und Schwellung der vielen Hautkrankheiten verwendet. Elocon Creme ist eine topische Kortikosteroide. Es wirkt, indem es Entzundungsreaktionen und Modifizieren Immunreaktionen im Korper.

Verwenden Sie Elocon Creme wie von Ihrem Arzt verordnet wurde.

Tragen Sie eine kleine Menge von Elocon Creme auf die betroffene Stelle einmal pro Tag. Reiben Sie die Medizin, bis sie gleichma?ig verteilt wird. Waschen Sie Ihre Hande nach dem Auftragen Elocon Cream, es sei denn, Ihre Hande Teil der behandelten Flache sind.

Wenn Sie eine Dosis von Elocon Creme, verwenden Sie es so bald wie moglich. Wenn es fast Zeit fur Ihre nachste Dosis ist, uberspringen Sie die vergessene Dosis und gehen Sie zuruck zu Ihrem regelma?igen Dosierungsschema. Verwenden Sie nicht 2 Dosen auf einmal.

Fragen Sie Ihren Arzt Fragen konnen Sie sich daruber, wie Sie Elocon Creme verwenden, haben konnen.

Shop Elocon Creme zwischen 59 und 86 Grad F (15 und 30 Grad C). Lager weg von der Hitze, Feuchtigkeit und Licht. Nicht im Bad. Halten Sie Elocon Creme aus der Reichweite von Kindern und weg von Haustieren.

Verwenden Sie KEINE Elocon Creme, wenn:

Sie sind allergisch gegen jegliche Zutaten in Elocon Cream.

Fragen Sie Ihren Arzt oder Ihre Arztin sofort, wenn einer dieser Punkte auf Sie zutreffen.

Einige medizinische Bedingungen konnen mit Elocon Creme interagieren. Informieren Sie Ihren Arzt oder Apotheker, wenn Sie irgendwelche medizinischen Bedingungen haben, vor allem, wenn einer der folgenden Punkte auf Sie zutrifft:

wenn Sie schwanger sind, planen, schwanger zu werden, oder stillen

wenn Sie verschreibungspflichtige oder nicht verschreibungspflichtige Arzneimittel, pflanzliche Zubereitung oder Nahrungserganzungsmittel

wenn Sie Allergien gegen Medikamente, Nahrungsmittel oder andere Substanzen,

wenn Sie Akne-ahnliche Lasionen, Masern, Entzundungen um den Mund; positive Tuberkulin-Hauttest, Tuberkulose, Varizellen (Windpocken); hatte kurzlich eine Impfung, haben eine Infektion der Haut oder Atrophie (verschwenden) der Haut.

Einige Arzneimittel konnen mit Elocon Creme interagieren. Weil wenig, wenn uberhaupt, von Elocon Creme in das Blut aufgenommen wird, ist die Gefahr, dass es die Interaktion mit anderen Medikamenten gering.

Dies kann nicht eine vollstandige Liste aller Interaktionen, die auftreten konnen. Fragen Sie Ihren Arzt, wenn Elocon Creme mit anderen Arzneimitteln, die Sie einnehmen. Prufen Sie mit Ihrem Arzt, bevor Sie starten, stoppen, oder andern Sie die Dosis einer Medizin.

Dies ist nur zur au?erlichen Anwendung. Vermeiden Sie den Kontakt mit den Augen. Verwenden Sie keine Elocon Creme auf dem Gesicht, Achseln oder Leistengegend, es sei denn beraten, wenn Sie von Ihrem Arzt oder Arztin.

Verwenden Elocon Creme nur fur die Haut Problem, fur das es bestimmt ist.

Nicht Verband oder decken den behandelten Bereich, es sei denn, dies wurde von Ihrem Arzt oder Arztin. Wenn Elocon Creme verschrieben wurde, um die Windel Bereich ein Kind zu behandeln, vermeiden Sie eng anliegende Windeln oder Gummihosen.

Stop mit Elocon Creme, wenn die Haut Gebiet wieder normal. Kontaktieren Sie Ihren Arzt, wenn die Verbesserung nicht innerhalb von 2 Wochen nicht gesehen.

Fragen Sie Ihren Arzt vor der Verwendung anderer Arzneimittel, Steroide. Wenn Sie unsicher sind, ob Ihr andere Medikamente Kortikosteroide enthalten, sind mit Ihrem Apotheker.

Vorsicht ist geboten bei der Verwendung Elocon Creme bei Kindern, sie moglicherweise empfindlicher auf deren Auswirkungen. Elocon Creme sollte nicht bei Kindern junger 2 Jahre verwendet werden, Sicherheit und Wirksamkeit bei diesen Kindern haben sich nicht bestatigt. Kortikosteroide konnen Wachstumsrate bei Kindern und Jugendlichen in einigen Fallen beeinflussen. Sie konnen regelma?ige Kontrollen Wachstum brauchen, wahrend sie Elocon Creme verwenden.

Schwangerschaft und Stillzeit: Wenn Sie schwanger werden, wenden Sie sich an Ihren Arzt. Sie mussen die Vorteile und Risiken der Verwendung von Elocon Creme zu diskutieren, wahrend Sie schwanger sind. Es ist nicht bekannt, ob Elocon Cream in der Muttermilch zu finden ist. Wenn Sie sind oder werden stillen, wahrend Sie Elocon Creme verwenden sind, mit Ihrem Arzt uberprufen. Diskutieren Sie mogliche Risiken fur Ihr Baby.

Alle Arzneimittel konnen Nebenwirkungen haben, die aber viele Menschen haben keine oder nur geringfugige, Nebenwirkungen.

Erkundigen Sie sich bei Ihrem Arzt, wenn dieser am haufigsten auftretenden Nebenwirkungen fortbestehen oder storend empfunden werden:

Brennen, Hitzegefuhl, Juckreiz, Rotung; zweite Infektion, die Haut dunner und Verfarbungen, Schwellungen, Kribbeln / Stechen; verschwenden der Haut.

Arztlich behandeln lassen, sofort, wenn dieser schwere Nebenwirkungen auftreten:

Schwere allergische Reaktionen (Hautausschlag, Nesselsucht, Juckreiz, Atembeschwerden, Engegefuhl in der Brust, Schwellungen im Mund-, Gesichts-, Lippen oder Zunge).

Dies ist keine vollstandige Liste aller Nebenwirkungen, die auftreten konnen. Wenn Sie Fragen zu Nebenwirkungen haben, wenden Sie sich an Ihren Arzt.

Kunden, die diesen Artikel gekauft haben, schaffen auch folgende Artikel an.

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Nimodipina Medlineplus Medicinas, Nidip

Nimodipina

Las capsulas y el liquido de nimodipina se deben tomar por la boca. Si no esta consciente o no puede tragar, es posible que se le administre el medicamento a traves de una sonda de alimentacion que se le coloca en la nariz o directamente en el estomago. La nimodipina no se debe administrar nunca de forma intravenosa (en la vena), ya que esto podria causar efectos secundarios graves o que pongan en peligro su vida, o incluso la muerte.

?Para cuales condiciones o enfermedades se prescribe este medicamento?

La nimodipina se usa para reducir el dano cerebral que puede ser ocasionado por una hemorragia por debajo del aracnoide (sangrado en el espacio que rodea el cerebro y que ocurre cuando estalla un vaso sanguineo debilitado del cerebro). La nimodipina pertenece a una clase de medicamentos llamados bloqueadores del canal de calcio. Funciona al relajar los vasos sanguineos del cerebro para permitir que fluya mas sangre a las areas danadas.

?Como se debe usar este medicamento?

La nimodipina tiene presentacion en capsulas y en solucion oral (liquido) para tomar por via oral o para administrar a traves de una sonda. Por lo general se toma cada 4 horas durante 21 dias consecutivos. El tratamiento con nimodipina se debe iniciar tan pronto sea posible, a mas tardar 96 horas despues de que ocurra una hemorragia por debajo del aracnoide. La nimodipina se debe tomar con el estomago vacio, por lo menos 1 hora antes de una comida o 2 horas despues de comer. Siga atentamente las instrucciones que se encuentran en la etiqueta de su receta medica y pida a su medico o farmaceutico que le explique cualquier parte que no comprenda. Tome la nimodipina exactamente como se indica. No tome mas ni menos cantidad del medicamento ni lo tome con mas frecuencia de lo que indica la receta de su medico.

Trague las capsulas enteras con agua.

Es importante terminar todo el tratamiento con nimodipina. Continue tomando nimodipina aunque se sienta bien. No deje de tomar la nimodipina sin hablar con su medico.

?Que otro uso se le da a este medicamento?

Este medicamento se puede recetar para otros usos. Pida mas informacion a su medico o farmaceutico.

?Cuales son las precauciones especiales que debo seguir?

Antes de tomar nimodipina,

indique a su medico y farmaceutico si es alergico a la nimodipina, a cualquier otro medicamento o a alguno de los ingredientes que contienen las capsulas o la solucion oral de nimodipina. Pida a su medico o farmaceutico una lista de los ingredientes.

Informe a su medico o farmaceutico si esta tomando alguno de los siguientes medicamentos: ciertos medicamentos antihongos incluyendo itraconazol (Onmel, Sporanox), cetoconazol (Nizoral) y voriconazol (Vfend); claritromicina (Biaxin); ciertos medicamentos para el VIH, incluyendo indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, en Kaletra) y saquinavir (Invirase); nefazodona; y telitromicina (Ketek). Su medico podria indicarle que no tome nimodipina.

Informe a su medico y farmaceutico que otros medicamentos con y sin receta medica, suplementos nutricionales y vitaminas esta tomando o tiene planificado tomar. Asegurese de mencionar cualquiera de los siguientes: aprepitant (Emend); armodafinil (Nuvigil); alprazolam (Niravam, Xanax); amiodarona (Cordarone, Pacerone, Nexterone); atazanavir (Reyataz), bosentan (Tracleer); cimetidina (Tagamet); conivaptan (Vaprisol); ciclosporina (Gengraf, Neoral, Sandimmune); delavirdina (Rescriptor);diltiazem (Cardizem, Dilacor, Tiazac); combinacion de dalfopristina/quinupristina (Synercid); efavirenz (Sustiva, en Atripla); eritromicina (E. E.S, E-Mycin); etravirina (Intelence); fluconazol (Diflucan); fluoxetina (Prozac, Sarafem, en Symbyax); isoniacida (en Rifater, en Rifamate); medicamentos para hipertension arterial o enfermedad del corazon incluyendo diureticos (pildoras que provocan la eliminacion de agua a traves de la orina): ciertos medicamentos para la hepatitis incluyendo boceprevir (Victrelis) y telaprevir (Incivek); ciertos medicamentos para convulsiones incluyendo carbamazepina (Carbatrol, Equetro, Tegretol), fenobarbital (Luminal) y fenitoina (Dilantin); modafinil (Provigil); nafcilina (Nallpen); anticonceptivos orales (pildoras para evitar embarazos); inhibidores de fosfodiesterasa (PDE-5) incluyendo sildenafil (Revatio, Viagra), tadalafil (Cialis) y vardenafilo (Levitra, Staxyn); pioglitazona (Actos, en Actoplus Met, en Duetact, en Oseni); posaconazol (Noxafil);prednisolona (Rayos); rifampicina (Rifadin, Rifater, Rimactane, en Rifamate); rufinamida (Banzel); acido valproico (Depakene); verapamilo (Calan, Covera, Tarka, Verelan) y vemurafenib (Zelburaf). Muchos otros medicamentos tambien podrian interactuar con nimodipina, asi que asegurese de informar a su medico sobre todos los medicamentos que esta tomando, incluso si no aparecen en esta lista. Es posible que su medico deba cambiar las dosis de sus medicamentos o supervisar mas de cerca si sufre efectos secundarios.

Informe a su medico que productos a base de plantas esta tomando, especialmente Equinacea y la hierba de San Juan.

Informe a su medico si sufre o alguna vez sufrio alguna enfermedad hepatica.

Informe a su medico si esta embarazada, si planea quedar embarazada o esta amamantando. Si queda embarazada mientras toma nimodipina, llame a su medico.

?Que dieta especial debo seguir mientras tomo este medicamento?

No tome jugo de toronja ni coma toronja mientras esta tomando nimodipina.

?Que tengo que hacer si me olvido de tomar una dosis?

Tome la dosis que omitio tan pronto como lo recuerde. Sin embargo, si ya casi es hora de la proxima dosis, no tome la dosis que omitio y continue con su dosificacion regular. No duplique la dosis para compensar la dosis omitida.

?Cuales son los efectos secundarios que podria provocar este medicamento?

La nimodipina puede ocasionar efectos secundarios. Informe a su medico si cualquiera de estos sintomas es grave o no desaparece:

Algunos efectos secundarios pueden ser graves. Si experimenta algunos de los siguientes sintomas, llame a su medico inmediatamente o busque tratamiento medico de emergencia:

mareos

mareos leves

ritmo cardiaco rapido o lento

inflamacion de los brazos, manos, pies o piernas

Si desarrolla un efecto secundario grave, usted o su doctor puede enviar un informe al programa de divulgacion de efectos adversos 'MedWatch' de la Administracion de Alimentos y Medicamentos (FDA, por su sigla en ingles) en la pagina de Internet (http://www. fda. gov/Safety/MedWatch ) o por telefono al 1-800-332-1088.

?Como debo almacenar o desechar este medicamento?

Mantenga este medicamento en su envase original, cerrado hermeticamente y fuera del alcance de los ninos. Almacenelo a temperatura ambiente y lejos de la luz, del exceso de calor y humedad (no en el bano). Deseche cualquier medicamento que este vencido o que ya no necesite. Hable con el farmaceutico sobre la forma adecuada para desechar el medicamento.

?Que debo hacer en caso de una sobredosis?

En caso de una sobredosis, llame a la oficina local de control de envenenamiento al 1-800-222-1222. Si la victima esta inconsciente, o no respira, llame inmediatamente al 911.

Ome 20 Ome 20 Pill - Omeprazole 20 Mg, Omecap

OME 20 OME 20 (Omeprazole 20 mg)

Pill imprint OME 20 OME 20 has been identified as Omeprazole 20 mg .

Omeprazole is used in the treatment of gerd; barrett's esophagus; gastritis/duodenitis; erosive esophagitis; duodenal ulcer (and more ), and belongs to the drug class proton pump inhibitors. Risk cannot be ruled out during pregnancy. Omeprazole 20 mg is not a controlled substance under the Controlled Substance Act (CSA).

Images for OME 20 OME 20

Omeprazole Imprint: OME 20 OME 20 Strength: 20 mg Color: White Size: 16.00 mm Shape: Capsule-shape Availability: Rx and/or OTC

Buy Actipram - Citalopram - Online Without Prescriptions, Actipram

Celexa (Actipram)

Celexa is used for treating depression. Celexa is a selective serotonin reuptake inhibitor (SSRI). It works by restoring the balance of serotonin, a natural substance in the brain, which helps to improve certain mood problems.

Use Celexa as directed by your doctor.

Take Celexa by mouth with or without food.

Taking Celexa at the same time each day will help you remember to take it.

Continue to take Celexa even if you feel well. Do not miss any dose.

Do not suddenly stop taking Celexa without checking with your doctor. Side effects may occur. They may include mental or mood changes, numbness or tingling of the skin, dizziness, confusion, headache, trouble sleeping, or unusual tiredness.

If you miss a dose of Celexa, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Celexa.

Store Celexa at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Celexa out of the reach of children and away from pets.

Active Ingredient: Citalopram hydrobromide.

Do NOT use Celexa if:

you are allergic to any ingredient in Celexa

you are taking escitalopram

you are taking or have taken a monoamine oxidase inhibitor (MAOI) (eg, phenelzine), selegiline, or St. John's wort within the last 14 days

you are taking a fenfluramine derivative (eg, dexfenfluramine), an H 1 antagonist (eg, astemizole, terfenadine), nefazodone, pimozide, or sibutramine.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Celexa. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you or a family member has a history of bipolar disorder (manic-depression), other mental or mood problems, suicidal thoughts or attempts, or alcohol or substance abuse

if you have a history of seizures, liver problems, severe kidney problems, stomach or bowel bleeding, or metabolism problems

if you are dehydrated, have low blood sodium levels, or drink alcohol

if you will be having electroconvulsive therapy (ECT).

Some medicines may interact with Celexa. Tell your health care provider if you are taking any other medicines, especially any of the following:

Fenfluramine derivatives (eg, dexfenfluramine), linezolid, lithium, MAOIs (eg, phenelzine), metoclopramide, nefazodone, selegiline, serotonin 5-HT 1 receptor agonists (eg, sumatriptan), sibutramine, St. John's wort, or trazodone because severe side effects, such as a reaction that may include fever, rigid muscles, blood pressure changes, mental changes, confusion, irritability, agitation, delirium, and coma, may occur

Anticoagulants (eg, warfarin), aspirin, or nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen) because the risk of bleeding, including stomach bleeding, may be increased

Diuretics (eg, furosemide, hydrochlorothiazide) because the risk of low blood sodium levels may be increased

Tramadol because the risk of seizures may be increased

H 1 antagonists (eg, astemizole, terfenadine) or phenothiazines (eg, chlorpromazine, thioridazine) because severe heart problems, including irregular heartbeat, may occur

Carbamazepine or cyproheptadine because they may decrease Celexa's effectiveness

Clozapine, pimozide, risperidone, or tricyclic antidepressants (eg, amitriptyline) because the risk of their side effects may be increased by Celexa.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Celexa may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Celexa may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Celexa with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Do not drink alcohol while you are using Celexa.

Check with your doctor before you use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Celexa; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.

One to 4 weeks may pass before your symptoms improve. Do NOT take more than the recommended dose, change your dose, or use Celexa for longer than prescribed without checking with your doctor.

Children, teenagers, and young adults who take Celexa may be at increased risk for suicidal thoughts or actions. Watch all patients who take Celexa closely. Contact the doctor at once if new, worsened, or sudden symptoms such as depressed mood; anxious, restless, or irritable behavior; panic attacks; or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur.

Celexa and a medicine called escitalopram have the same active ingredient. Do not take Celexa if you are also taking escitalopram.

If your doctor tells you to stop taking Celexa, you will need to wait for several weeks before beginning to take certain other medicines (eg, MAOIs, nefazodone). Ask your doctor when you should start to take your new medicines after you have stopped taking Celexa.

Celexa may rarely cause a prolonged, painful erection. This could happen even when you are not having sex. If this is not treated right away, it could lead to permanent sexual problems such as impotence. Contact your doctor right away if this happens.

Serotonin syndrome is a possibly fatal syndrome that can be caused by Celexa. Your risk may be greater if you take Celexa with certain other medicines (eg, "triptans," MAOIs). Symptoms may include agitation; confusion; hallucinations; coma; fever; fast or irregular heartbeat; tremor; excessive sweating; and nausea, vomiting, or diarrhea. Contact your doctor at once if you have any of these symptoms.

Neuroleptic malignant syndrome (NMS) is a possibly fatal syndrome that can be caused by Celexa. Symptoms may include fever; stiff muscles; confusion; abnormal thinking; fast or irregular heartbeat; and sweating. Contact your doctor at once if you have any of these symptoms.

Use Celexa with caution in the elderly; they may be more sensitive to its effects, especially low blood sodium levels.

Caution is advised when using Celexa in children; they may be more sensitive to its effects, especially increased risk of suicidal thoughts or actions.

Celexa should be used with extreme caution in children; safety and effectiveness in children have not been confirmed.

Celexa may cause weight changes. Children and teenagers may need regular weight and growth checks while they take Celexa.

Pregnancy and breast-feeding: Celexa may cause harm to the fetus if it is used during the last 3 months of pregnancy. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Celexa while you are pregnant. Celexa is found in breast milk. Do not breastfeed while taking Celexa.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Decreased sexual desire or ability; diarrhea; dizziness; drowsiness; dry mouth; increased sweating; lightheadedness when you stand or sit up; loss of appetite; nausea; stuffy nose; tiredness.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); absent menstrual period; bizarre behavior; black or bloody stools; chest pain; confusion; decreased concentration; decreased coordination; fainting; fast or irregular heartbeat; hallucinations; memory loss; new or worsening agitation, panic attacks, aggressiveness, impulsiveness, irritability, hostility, exaggerated feeling of well-being, restlessness, or inability to sit still; persistent, painful erection; red, swollen, blistered, or peeling skin; seizures; severe or persistent anxiety or trouble sleeping; severe or persistent headache; stomach pain; suicidal thoughts or attempts; tremor; unusual bruising or bleeding; unusual or severe mental or mood changes; unusual weakness; vision changes; worsening of depression.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Fluconazole Medlineplus Drug Information, Flucozole

Fluconazole

Fluconazole is used to treat fungal infections, including yeast infections of the vagina, mouth, throat, esophagus (tube leading from the mouth to the stomach), abdomen (area between the chest and waist), lungs, blood, and other organs. Fluconazole is also used to treat meningitis (infection of the membranes covering the brain and spine) caused by fungus. Fluconazole is also used to prevent yeast infections in patients who are likely to become infected because they are being treated with chemotherapy or radiation therapy before a bone marrow transplant (replacement of unhealthy spongy tissue inside the bones with healthy tissue). Fluconazole is in a class of antifungals called triazoles. It works by slowing the growth of fungi that cause infection.

How should this medicine be used?

Fluconazole comes as a tablet and a suspension (liquid) to take by mouth. It is usually taken once a day, with or without food. You may need to take only one dose of fluconazole, or you may need to take fluconazole for several weeks or longer. The length of your treatment depends on your condition and on how well you respond to fluconazole. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take fluconazole exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor may tell you to take a double dose of fluconazole on the first day of your treatment. Follow these directions carefully.

Shake the liquid well before each use to mix the medication evenly.

You should begin to feel better during the first few days of treatment with fluconazole. If your symptoms do not improve or get worse, call your doctor.

Continue to take fluconazole until your doctor tells you that you should stop, even if you feel better. Do not stop taking fluconazole without talking to your doctor. If you stop taking fluconazole too soon, your infection may come back after a short time.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

Other uses for this medicine

Fluconazole is also sometimes used to treat serious fungal infections that begin in the lungs and can spread through the body and fungal infections of the eye, prostate (a male reproductive organ), skin and nails. Fluconazole is also sometimes used to prevent fungal infections in people who are likely to become infected because they have human immunodeficiency virus (HIV) or cancer or have had a transplant operation (surgery to remove an organ and replace it with a donor or artificial organ). Talk to your doctor about the possible risks of using this medication for your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking fluconazole,

tell your doctor and pharmacist if you are allergic to fluconazole, other antifungal medications such as itraconazole (Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), or voriconazole (Vfend), any other medications, or any of the ingredients in fluconazole tablets or suspension. Ask your pharmacist for a list of the ingredients.

tell your doctor if you are taking astemizole (Hismanal) (not available in the US), cisapride (Propulsid) (not available in the US), erythromycin (E. E.S. E-Mycin, Erythrocin); pimozide (Orap), quinidine (Quinidex), or terfenadine (Seldane) (not available in the US). Your doctor will probably tell you not to take fluconazole if you are taking any of these medications.

tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking, or plan to take. Also you should tell your doctor you have taken fluconazole before starting to take any new medications within 7 days of receiving fluconazole. Be sure to mention any of the following: amitriptyline; amphotericin B (Abelcet, AmBisome, Amphotec, Fungizone); anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); benzodiazepines such as midazolam (Versed); calcium channel blockers such as amlodipine (Norvasc, in Caduet, in Lotrel), felodipine (Plendil, in Lexxel), isradipine (DynaCirc), and nifedipine (Adalat, Procardia); carbamazepine (Carbatrol, Epitol, Tegretol); celecoxib (Celebrex); cholesterol-lowering medications (statins) such as atorvastatin (Lipitor, in Caduet), fluvastatin (Lescol), and simvastatin (Zocor, in Simcor, in Vytorin); clopidogrel (Plavix); cyclophosphamide (Cytoxan); cyclosporine (Gengraf, Neoral, Sandimmune); diuretics ('water pills') such as hydrochlorothiazide (HydroDIURIL, Microzide); fentanyl (Actiq, Duragesic, Fentora, Sublimaze); isoniazid (INH, Nydrazid); losartan (Cozaar, in Hyzaar); methadone (Methadose); nevirapine (Viramune); nonsteroidal anti-inflammatory drugs (NSAIDS) such as ibuprofen (Advil, Motrin, others) and naproxen (Aleve, Anaprox, Naprelan); oral contraceptives (birth control pills); oral medication for diabetes such as glipizide (Glucotrol), glyburide (Diabeta, Micronase, Glycron, others), and tolbutamide (Orinase); nortriptyline (Pamelor); phenytoin (Dilantin, Phenytek); prednisone (Sterapred); rifabutin (Mycobutin); rifampin (Rifadin, Rimactane, in Rifamate, in Rifater); saquinavir (Invirase); sirolimus (Rapamune); tacrolimus (Prograf); theophylline (Elixophyllin, Theo-24, Uniphyl, others); tofacitinib (Xeljanz); triazolam (Halcion); valproic acid (Depakene, Depakote); vinblastine; vincristine; vitamin A; voriconazole (Vfend); and zidovudine (Retrovir). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with fluconazole, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

tell your doctor if you have or have ever had cancer; acquired immunodeficiency syndrome (AIDS); an irregular heartbeat; a low level of calcium, sodium, magnesium, or potassium in your blood; rare, inherited conditions where the body is not able to tolerate lactose or sucrose;or heart, kidney, or liver disease.

tell your doctor if you are pregnant, especially if you are in the first 3 months of your pregnancy, plan to become pregnant, or are breast-feeding. If you become pregnant while taking fluconazole, call your doctor. Fluconazole may harm the fetus.

if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking fluconazole.

you should know that fluconazole may make you dizzy or cause seizures. Do not drive a car or operate machinery until you know how this medication affects you.

What special dietary instructions should I follow?

Fluconazole may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

headache

dizziness

diarrhea

stomach pain

heartburn

change in ability to taste food

Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately or get emergency treatment:

nausea

vomiting

extreme tiredness

unusual bruising or bleeding

lack of energy

loss of appetite

pain in the upper right part of the stomach

yellowing of the skin or eyes

flu-like symptoms

dark urine

pale stools

seizures

rash

blistering or peeling skin

hives

itching

swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs

difficulty breathing or swallowing

Fluconazole may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www. fda. gov/Safety/MedWatch ) or by phone (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Throw away any unused liquid medication after 14 days. Talk to your pharmacist about the proper disposal of your medication.

In case of emergency/overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Symptoms of overdose may include the following:

hallucinations (seeing things or hearing voices that do not exist)

extreme fear that others are trying to harm you

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your response to fluconazole.

Do not let anyone else use your medication. Ask your pharmacist if you have questions about refilling your prescription. If you still have symptoms of infection after you finish taking the fluconazole, call your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand names

Elstatin (20mg), Elstatin

Elstatin (20mg)

Dysbetalipoproteinemia, Hypercholesterolaemia, Hypertriglyceridaemia, Secondary Hyperlipidemias.

Mechanism of action of Lovastatin :

Lovastatin Is A Prodrug That Is Activated In Vivo Via Hydrolysis Of The Lactone Ring To Form The ?-hydroxyacid. The Hydrolyzed Lactone Ring Mimics The Tetrahedral Intermediate Produced By The Reductase Allowing The Agent To Bind To HMG-CoA Reductase With 20,000 Times Greater Affinity Than Its Natural Substrate.

Drug Interaction of Lovastatin :

Lovastatin Is Known To Interact With Other Drugs Like Clarithromycin, Cyclosporin A, Itraconazole, Ketoconazole, Mibefradil (Di HCl), Pectin, Pioglitazone, Repaglinide, Silymarin, Warfarin (Na). Always Consult Your Physician For The Change Of Dose Regimen Or An Alternative Drug Of Choice That May Strictly Be Required.

Side effects of Lovastatin :

Weakness, Nausea, Diarrhea, Myalgia, Constipation, Abdominal Pain, Skin Rash, Rhabdomyolysis, Muscle Tenderness, Elevation Of CPK, Muscle Pain.

INTERACTIONS OF LOVASTATIN

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