Montano Flamiano - Associates Law Experienced Corporate And Annulment Lawyers In The Philippines, Jo

Dear PAO, I am a mother of three children. My husband left us, and we have been separated for 15 years now. He has not given enough support for our children. For the most part, he will just give when and as he pleases. Now that our children are in college, he no longer provides support.

If truth be told, I am no longer after the support for my children. I was able to raise them with very little support from my husband. I am more after now for the nullification of our marriage so that I can finally free myself from him, and so that if ever I will invest in properties, it will not form part of our community property, because it will be unfair for me and for my children. What are the requirements needed and the process which I must undertake? I hope you can advise me. Thank you and more power. Jhing

Dear Jhing, Physical separation between spouses does not necessarily entitle either party to the filing of a petition to nullify or annul his or her marriage. Our laws require that there be legal basis in filing such petition in court.

Pursuant to our Family Code, only the following are considered as valid grounds for the declaration of absolute nullity of marriage: (1) either party is below 18 years of age, even with the consent of parents or guardians; (2) marriage was solemnized by a person not legally authorized to perform marriages, unless it was contracted with either or both parties believing in good faith that the solemnizing officer had the legal authority to do so; (3) marriage was solemnized without license, except those allowed under the law; (4) bigamous or polygamous marriages not falling under Article 41; (5) marriage was contracted through mistake of one contracting party as to the identity of the other; (6) subsequent marriages that are void under Article 53; (7) either party was psychologically incapacitated to comply with the essential marital obligations of marriage at the time of the celebration of the marriage; (8) incestuous marriages; (9) marriages which are void from the beginning for reasons of public policy (Articles 35, 36, 37 and 38, Ibid.)

Insofar as filing a petition for annulment of marriage, any of the following grounds must be present: (1) either party was 18 years of age or over but below twenty-one, and the marriage was solemnized without the consent of his parents, guardian or person having substitute parental authority over the party, in that order, unless after attaining the age of twenty-one, he/she freely cohabited with the other party; (2) either party was of unsound mind, unless such party after coming to reason, freely cohabited with the other as husband and wife; (3) consent of either party was obtained by fraud, unless such party afterwards, with full knowledge of the facts constituting the fraud, freely cohabited with the other; (4) the consent of either party was obtained by force, intimidation or undue influence, unless the same having disappeared or ceased, such party thereafter freely cohabited with the other; (5) either party was physically incapable of consummating the marriage with the other, and such incapacity continues and appears to be incurable; or (6) either party was afflicted with a sexually-transmissible disease found to be serious and appears to be incurable (Article 45, Id.)

Accordingly, you may only file a petition to nullify or annul your marriage if any of the foregoing grounds exist in your marriage. Such petition must be filed before the regional trial court, sitting as a family court, of the place where you reside or where your husband resides, at your election. Should the court grant your petition, the absolute community of property or the conjugal partnership which was established between you and your husband during your marriage, as the case may be, shall be dissolved and liquidated. (Article 43 (2) in relation to Article 50, Id.) Any property acquired thereafter shall solely belong to the party who purchased or obtained it, or to whoever is named as donee if it be by reason of donation.

We hope that we were able to answer your queries. Please be reminded that this advice is based solely on the facts you have narrated and our appreciation of the same. Our opinion may vary when other facts are changed or elaborated.

Editor’s note: Dear PAO is a daily column of the Public Attorney’s Office. Questions for Chief Acosta may be sent to [email protected] net

Source: The Manila Times

He calls you from time to time wanting to get back together. You’ve told him that you two are better off living separate lives, but he’s just not getting the hint. Sometimes, he would send you text messages at 3:00 a. m. visit you at work, or worse, stalk you.

You two dated for a while but there was really no spark between you two–you can’t even remember his name or what he looks like.

The guy you’re better off being friends with

You two started off as friends and developed feelings at some point. The problem is, the more you got to know him, the more you wanted him to remain your friend instead of being your boyfriend. He’s fun, protective, and easy to be with–but you’d rather save the friendship than spend forever with him.

The one you made a promise to marry to by the time you reach a certain age

A friend you can rely on every d*mn time. Sharon Cuneta and Aga Muhlach’s movie, Kung Ako Na Lang Sana, is the perfect example. As long as you’re both single, the offer still stands.

The one you’ll never seem to get over

This guy would always be the standard for your future boyfriends. Sometimes, you catch yourself thinking about him when you’re supposed to be getting over him. He seemed to be the perfect guy, but things between you two just didn’t work so you decided to part ways.

The guy your family misses

Your family likes him so much that your mom, dad, and younger siblings keep asking what *insert his name here* has been up to. They always ask you how he is and when he’ll be visiting you so they could hang out again.

The one that got away

It was the perfect love story until something or someone got in the way between you two–it could be your parents, pride, or a simple misunderstanding that was blown out of proportion. He’s the guy you wish you had another chance with and given that opportunity, you’ll try your best to make everything work with.

When was the last time you thanked your partner for the effort and love they’ve put into your relationship? Recent research from the University of Georgia, from the U. S. shows that the key to a better marriage might lie in this one simple word: gratitude.

The study was published in the journal Personal Relationships .

“We found that feeling appreciated and believing that your spouse values you directly influences how you feel about your marriage, how committed you are to it, and your belief that it will last,” said study co-author Ted Futris . In short, you’ll feel more secure in your relationship if you know that your spouse appreciates you.

The study involved a survey of near 468 participants asking about their financial well-being, how well they communicated and how often they expressed gratitude to one another.

Results showed that “expression of gratitude” was “the most consistent significant predictor of marital quality”. Couples who showed gratitude and appreciation for one another even through times of distress tended to be happier about their relationship.

In particular, they found that showing gratitude acted as a buffer from poor communication brought about by financial troubles. “When couples are stressed about making ends meet, they are more likely to engage in negative ways. They are more critical of each other and defensive, and they can even stop engaging or withdraw from each other, which can then lead to lower marital quality,” says Futris.

“It goes to show the power of ‘thank you,’” says lead author Allen Barton . a postdoctoral research associate at the university. “Even if a couple is experiencing distress and difficulty in other areas, gratitude in the relationship can help promote positive marital outcomes.”

Concluding, Futris shares his advice. “What distinguishes the marriages that last from those that don’t is not how often they argue, but how they argue and how they treat each other on a daily basis.”

It is a profound pleasure for us in the law firm to attend a union of clients who were given second chances in life like this lovely wedding in San Juan, Batangas. Kudos to Mr. and Mrs. Grassi!

Atty. Francisco “Atty. Jojo” R. Flamiano, Jr. attending a Family Law Seminar in Melbourne, Australia last 29 April 2014 sponsored by Carew Counsel Family Law Barristers and Solicitors, with focus on divorce, division of property, and child custody.

Annulment vs. Divorce

While annulment and divorce are similar in concept and process, an annulment treats the marriage as if it never happened. Legally, an annulment declares that the marriage was never valid and therefore never existed.

Divorce is the legal dissolution of a valid marriage. The outcome in divorce is not that the marriage never existed, but that it is legally concluded and that each party now has single status and the ability to remarry if so desired.

Common Grounds for Annulment or Divorce

Both parties in the marriage have the right and ability to initiate either annulment or divorce proceedings. The party initiating the process must prove to the court that he or she has the grounds to begin the annulment or divorce process.

While grounds for annulment and divorce vary from state to state and country to country, there are some requirements that are common in nearly every state and in many countries around the world.

Grounds for Annulment

Bigamy . One party was already married to someone else at the time of the marriage.

Fraud: One party agreed to the marriage based on gross misrepresentation of the other party.

Inability to Consummate Marriage: One party was unable to have sexual relations during the marriage.

Psychological Incapacity: One party has a mental illness or was determined to be under extreme emotional duress at the time of the marriage.

Mental Incapacity . One party is or was under the influence of drugs or alcohol at the time of the marriage.

Prohibited Marriage: The marriage was between parties who are related.

Grounds for Divorce

Adultery: One party has engaged in extramarital relationships during the marriage.

Desertion: One party physically and/or emotionally abandons the other for a long period of time.

Irreconcilable Differences: Both parties have differences that make living together and being in a relationship impossible.

Physical or Emotional Abuse: One party subjects the other party to violent physical attacks or emotional abuse such as threats of violence and other harsh language.

Is Getting an Annulment or Divorce Difficult?

Annulments are usually sought within a few days or weeks of the marriage. Pop culture aficionados may remember that Britney Spears married a childhood friend in Las Vegas, then got the marriage annulled two days later.

With the duration of the marriage being extremely short in most annulment cases, the legal process is generally very quick, as there are few financial or custodial matters to be concerned with.

Divorce, on the other hand, can be a much longer, messier process. In most divorce cases, finances must be dealt with and assets must be divided. If there are children involved, child custody must be determined, as well as child support and visitation rights.

The law in your state or country and the particulars of your individual situation will contribute to whether your annulment or divorce will be a simple process or not. It’s best to find legal representation and familiarize yourself with the law in case of an annulment or divorce.

“I saw the texts Dad sent you last night,” my eldest son said to me recently. He hung his head sadly.

We had amended our parenting time schedule to accommodate some work travel for me, and I was planning to take my son to lunch on his birthday since I wouldn’t see him that day. His dad didn’t want me taking our son to lunch on what he saw as “his time.” He spit at me in text messages. I spit back, having not learned even five years after divorcing to just not engage in the madness.

Ready to begin dating with kids. Here are nine tips to help you get started.

It’s ridiculous that my ex and I still have bouts this long after we split; it’s even worse when the kids get tied up in our stupidity.

“Dad told me you were going to say bad things about him,” my son said. I never disparage my ex to our children, yet I had to reassure my son. He knew it would never happen, but I could see how much it hurt him to even consider the idea. And it should. No kid asks to be part of a divorced scenario, and they shouldn’t have to bear the brunt of adult mistakes.

I told my son we both love him, and said it isn’t fair to involve him in our bad behavior. I’m not proud that, at 41, I still can’t play nicely with my ex all the time.

Divorce can bring out the worst in us. Perhaps there’s lingering hurt because one person left, or someone cheated, or someone fell out of love.

But whatever the reason that prompts a split, it’s never OK to drag kids through the mud. They are part mom, part dad, and if ex-spouses can remember that, they’ll be on a good path to successful co-parenting.

Solo moms and dads can’t do it alone. Check out our single parent survival guide .

“The biggest obstacles to successful co-parenting are emotions,” says Alisa Peskin-Shepherd, principal of Transitions Legal, a family law practice in Bloomfield Hills that specializes in mediative divorce. “Emotional obstacles are usually anger, resentment and jealousy. Often parents have a hard time separating those feelings toward their former spouse from their attempt to focus on their children.”

It may be easier said than done to “focus on the children,” but here are 10 tips for doing it well from local parents who are succeeding in co-parenting without resentment.

1. Start with a ‘timeout’

Take time to reflect on how your behavior and your decisions are affecting your child, says Peskin-Shepherd. “Especially where there is constant disagreement, try to accept that you are not going to change the other person and find a way to make something work without being dependent on the other parent’s response.”

If you can’t do it yourself, consult a “co-parenting coordinator,” attorney or counselor – with or without your ex-spouse. Having an objective third party guide you can be incredibly helpful.

“Our expectations that two people who didn’t get along when they are married will suddenly be able to co-parent without some help is not reasonable,” Peskin-Shepherd says.

It is imperative for ex-spouses to heal fully from the pain of divorce if they plan to co-parent effectively, says Alison Willett, a Birmingham resident and psychologist who has worked with high-conflict divorce and is the mother of three daughters and two step-daughters.

“People going through divorce need to take the necessary time to grieve the end of this major relationship and remember that at one time, they loved or cared about the other parent,” says Willett. “When parents are psychologically intact, it will be easier for them to put the needs of their children first.”

2. Play to your ex’s strengths

“You probably know your ex-spouse better than anyone else,” says Chris Tucker, Oak Park father of Finn, 9, and Simon, 7, and step-dad to Lucas, 6. “Play to those strengths – not in a manipulative way, but in a spirit of making the best use of one another’s talents.”

Tucker has his boys two-thirds of the year; their mother visits monthly from Virginia and takes them over school breaks and summer. Tucker, his wife, his ex-wife and her husband work well together to parent the children.

“We like to think of ourselves – Colleen, her husband, my wife and I – as members of a family ecosystem,” says Tucker. “This means that everyone involved is invested in and accountable for raising our kids, and it goes a long way in building trust and mutual respect.”

3. Commit to cooperation

Effective co-parenting does not require friendship, says Shaindle Braunstein-Cohen, West Bloomfield mother of Seth, 14, but it does require cooperation.

“My ex and I get along when we have contact, but we never have contact outside of our son,” she says. “When my son wanted to show his dad his new room in our new home, he did. Successful co-parenting involves only one thing: loving your child more than you hate your ex.”

Because her ex moved out-of-state, Braunstein-Cohen has her son full-time. However, when he wants to see his dad or vice versa, they bend over backwards to make it happen. “Sure, that meant I had many holidays without him, but it wasn’t about me,” she says.

It also does no good to stay mired in the past.

“The kids can become an obsession, a club to beat your ex over the head with,” says Braunstein-Cohen. “You can’t live in the past, and you also can’t live in the future. Just live in the now. The moment is here; it’s what you’ve got. Make the best of it.”

In that effort, Peskin-Shepherd advises divorced parents to put everything in writing and kindly communicate your plans to the other parent, to establish a path of collegiality – even when you don’t have to.

Vacation time and money issues are common post-divorce problems, she says. “Parents can agree on how to pay for extracurricular activities, summer camps, boots and winter coats,” she says. “Have a mindset of cooperation to avoid problems. Likely the compromise your ex-spouse is asking of you today will be the one you need tomorrow.”

4. Set high intentions

Keely Henry did not want the ugliness of her divorce to run her life or affect her son, Sullivan, 8. “I knew I could not let this ugly experience lead our lives,” she says. “I was going to have to communicate with my ex over the course of our son’s life. The only thing to do was set the ideal on a higher notion, above emotional distress.”

Henry and her ex celebrate holidays and birthdays with Sully together – including Henry’s new life partner and her ex’s partner, the woman he left her for. “We all collaborate on my son’s parenting, with his dad and I as the final sayers,” she says. “It really is simple. Set the goal for the higher, not the lower.”

5. Let go of control

Thirteen years after their divorce, Jodi Rubin and her ex-husband still disagree about the same things they didn’t agree about when they were married. But they’ve reached a place of mutual respect and effective co-parenting for their three children, Jordan, 19, Paige, 15, and Ethan, 13.

So he lets them play video games more than you do or keeps them up too late on a school night. So what? Unless the kids are truly in emotional or physical jeopardy, let go of the need to control every moment of their lives. What happens at the other parent’s house, stays there – and vice versa.

“It’s not about you,” says Rubin, a Royal Oak resident. “Instead of worrying about each other, worry about the kids. It’s a parent’s job to turn their children into productive and emotionally healthy adults, and you can’t do that if you’re focused on each other.”

6. Silence your support system

It doesn’t help when your mother complains about your ex or his father sends nasty emails. A support system needs to remain impartial and follow the same co-parenting advice: Keep all eyes on the kids and not on the nasty details of your breakup.

“There were times I had to check my mom as she ranted and raved about what went down,” Henry says. “Or girlfriends – awesome friends who had not been married or had children – not understanding how I could handle some of the things the way I did. There were moments I could hardly do anything but scream and cry – and I did, but on my own watch. There will be tough times. You can get something positive from them.”

Linda Ferrante’s divorce runs smoothly because she and her ex involve their respective ex-inlaws in raising their son, Anthony, 10. The Farmington Hills mother encourages her son to call his father’s parents on holidays and her ex asks her parents to baby-sit. The village they’ve created to raise their son works well to give him a sense of security and safety, she says.

7. Check your ego at the door

While it is tempting to play into the “lizard brain” fear that your children will love your ex more than they love you, it’s immature and stupid. Resist the urge.

“It’s easy to see your ex-spouse as a threat,” says Tucker. “Remind yourself that your ex is also your children’s parent and would also step in front of a bus for them. Trust that they also have your children’s best interests at heart.”

Says Braunstein-Cohen, “Be totally honest with yourself. Everyone has ego involved; they want their child to know they were not at fault, that they are a better parent. Let it go and really think about what makes your kids happy.

“Obviously you don’t agree or sometimes even like each other very much – that’s why you got divorced,” she adds. “Get over it.”

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Diclofenac Informaci - N Espa - Ola De La Droga, Diclonex

diclofenac

¿Qué es diclofenac?

Diclofenac es una droga antiinflamatoria no esteroide (AINE o NSAID, por sus siglas en inglés). Esta medicina trabaja reduciendo sustancias en el cuerpo que causan dolor e inflamación.

Diclofenac se usa para tratar el dolor leve a moderado, o los signos y síntomas de la osteoartritis o artritis reumatoide. La marca Cataflam de esta medicina también se usa para tratar los cólicos menstruales.

Diclofenac en polvo (Cambia) se usa para el tratamiento de ataques de migrañas. Cambia no tratará un dolor de cabeza que ya ha empezado. Este no evitará los dolores de cabeza o reducirá la cantidad de ataques.

Diclofenac puede también usarse para fines no mencionados en esta guía del medicamento.

¿Cuál es la información más importante que debo saber sobre diclofenac?

Diclofenac puede aumentar su riesgo de ataques al corazón o accidentes cerebrovasculares fatales, especialmente si usted la usa por largo tiempo o toma dosis elevadas, o si tiene enfermedad del corazón. No use esta medicina justo antes o después de tener una cirugía de puente (bypass) aortocoronario con injerto (CABG por sus siglas en Inglés).

Diclofenac también puede causar sangrado del estómago o intestino, lo que podría ser fatal. Estas condiciones pueden ocurrir sin ninguna advertencia mientras esté usando diclofenac, especialmente en los adultos mayores.

¿Qué debería discutir con el profesional de la salud antes de tomar diclofenac?

Diclofenac puede aumentar su riesgo de ataques al corazón o accidentes cerebrovasculares fatales, especialmente si usted la usa por largo tiempo o toma dosis elevadas, o si usted tiene enfermedad del corazón. Aun las personas sin enfermedad del corazón o factores de riesgo podrían tener un accidente cerebrovascular o ataque al corazón mientras toman esta medicina.

No use esta medicina justo antes o después de tener una cirugía de puente (bypass) aortocoronario con injerto (CABG por sus siglas en Inglés).

Diclofenac también puede causar sangrado del estómago o intestino, lo que podría ser fatal. Estas condiciones pueden ocurrir sin ninguna advertencia mientras esté usando diclofenac, especialmente en los adultos mayores.

Usted no debe usar diclofenac si es alérgico a éste, o si usted alguna vez ha tenido un ataque de asma o reacción alérgica severa después de tomar aspirin o un AINE.

No use Cambia para el tratamiento de dolores de cabeza en racimo (cluster). No use Zipsor si usted es alérgico a la carne de res (vaca) o a la proteínas de la carne.

Para asegurarse que diclofenac es seguro para usted, dígale a su médico si usted tiene:

enfermedad del corazón, presión arterial alta, colesterol elevado, diabetes, o si fuma;

un historial de ataque al corazón, accidente cerebrovascular, o coágulo sanguíneo;

un historial de úlceras o de sangrados en el estómago;

enfermedad del hígado o riñón; o

retención de líquido.

Tomar diclofenac en los últimos 3 meses del embarazo puede hacerle daño al bebé nonato. Dígale a su médico si usted está embarazada o planea un embarazo.

No se sabe si diclofenac pasa a la leche materna o si le puede hacer daño al bebé lactante. Usted no debe amamantar mientras usa esta medicina.

Diclofenac no está aprobada para usarse en cualquier persona menor de 18 años de edad.

¿Cómo debo tomar diclofenac?

Diferentes marcas de diclofenac contienen cantidades diferentes de la medicina y pueden tener diferentes usos . Si cambia de marca, su dosis puede cambiar. Siga las instrucciones de su médico acerca de la cantidad de medicina que debe tomar. Consulte con su farmacéutico si usted tiene alguna pregunta acerca de la marca de diclofenac que recibe en la farmacia.

Siga todas las instrucciones en la etiqueta de su prescripción. Tal vez su médico en ocasiones cambie su dosis para asegurarse de que está obteniendo los mejores resultados. No tome esta medicina en cantidades mayores, o por más tiempo de lo recomendado. Use la dosis más baja que es efectiva en el tratamiento de su condición.

Tome Zorvolex con el estómago vacío, por lo menos 1 hora antes o 2 horas después de comer una comida.

No triture, mastique, o rompa una tableta de liberación extendida o tableta de liberación retardada . Tráguela entera.

Disuelva el diclofenac en polvo (Cambia) con 1 a 2 onzas de agua. No use ningún otro tipo de líquido. Revuelva la mezcla y beba todo de inmediato. El diclofenac en polvo funciona mejor si lo toma con el estómago vacío.

Llame a su médico si su dolor de cabeza no desaparece después de tomar Cambia. No tome una segunda dosis de diclofenac en polvo sin la aprobación de su médico.

Si usted usa diclofenac a largo plazo, usted puede necesitar pruebas médicas frecuentes.

Guarde a temperatura ambiente lejos de la humedad y calor. Mantenga la botella bien cerrada cuando no la esté usando.

Lea toda la información para el paciente, las guías del medicamento y las hojas de instrucción que le proporcionaron. Hable con su médico o farmacéutico si tiene alguna pregunta.

¿Qué sucede si me salto una dosis?

Tome la dosis que dejó de tomar tan pronto se acuerde. Sáltese la dosis que dejó de tomar si ya casi es hora para la siguiente dosis. No use más medicina para alcanzar la dosis que dejó de tomar.

¿Qué sucedería en una sobredosis?

Busque atención médica de emergencia o llame a la línea de Poison Help al 1-800-222-1222.

¿Qué debo evitar mientras tomo diclofenac?

No consuma alcohol mientras esté tomando diclofenac. El alcohol puede aumentar su riesgo de sangrado del estómago.

Evite tomar aspirin u otros AINEs mientras esté tomando diclofenac.

Pregúntele a su médico o farmacéutico antes de usar cualquier medicamento para el resfriado, alergias, o el dolor. Muchas de las medicinas que se consiguen sin receta contienen aspirin u otras medicinas similares a diclofenac. El tomar ciertos productos juntos puede hacer que tome demasiado de este tipo de medicamento. Revise la etiqueta para ver si una medicina contiene aspirin, ibuprofen, ketoprofen, o naproxen.

¿Cuáles son los efectos secundarios posibles de diclofenac?

Busque atención médica de emergencia si tiene síntomas de una reacción alérgica: estornudo, nariz mocosa o congestionada; silbido o dificultad para respirar; ronchas; hinchazón de la cara, labios, lengua, o garganta.

Busque ayuda médica de emergencia si usted tiene síntomas de un ataque al corazón o accidente cerebrovascular: dolor del pecho que se extiende a la mandíbula u hombro, entumecimiento o debilidad repentina en un lado de su cuerpo, habla arrastrada, sensación de que le falta aire al respirar.

Deje de usar diclofenac y llame a su médico de inmediato si usted tiene:

el primer signo de cualquier sarpullido, no importa que sea muy leve;

falta de aire al respirar (aún cuando la actividad es leve);

hinchazón o aumento de peso rápido;

signos de sangrado en el estómago-- heces con sangre o alquitranadas, tos con sangre o vómito que parece café molido;

problemas del hígado--náusea, dolor en la parte superior del estómago, picazón, sensación de cansancio, síntomas parecidos a la gripe, pérdida del apetito, orina oscura, heces fecales de color arcilla, ictericia (color amarillo de la piel u ojos);

problemas del riñón--orinar poco o nada, dolor o dificultad al orinar, hinchazón en sus pies o tobillos, sensación de cansancio o le falta aire al respirar;

presión arterial alta--dolor de cabeza severo, palpitaciones en su cuello o en sus oídos, sangrado por la nariz, ansiedad, confusión;

bajo conteo de glóbulos rojos (anemia)--piel pálida, sentir que se va a desmayar o le falta aire al respirar, latido cardíaco rápido, dificultad para concentrarse; o

reacción severa de la piel--fiebre, dolor de garganta, hinchazón en su cara o lengua, quemazón en sus ojos, dolor de la piel seguido por un sarpullido rojo o púrpura que se extiende (especialmente en la cara o la parte superior del cuerpo) y causa ampollas y descamación.

Efectos secundarios comunes pueden incluir:

indigestión, gas, dolor de estómago, náusea, vómito;

dolor de cabeza, mareo, somnolencia;

picazón, aumento del sudor;

aumento de la presión arterial; o

hinchazón o dolor en sus brazos o piernas.

Esta lista no menciona todos los efectos secundarios y puede ser que ocurran otros. Llame a su médico para consejos médicos relacionados a efectos secundarios. Usted puede reportar efectos secundarios llamando al FDA al 1-800-FDA-1088.

¿Qué otras drogas afectarán a diclofenac?

Pregúntele a su médico antes de usar diclofenac si usted toma un antidepresivo como citalopram, escitalopram, fluoxetine (Prozac), fluvoxamine, paroxetine (Paxil), sertraline (Zoloft), trazodone, o vilazodone. Tomar cualquiera de estas medicinas con un AINE puede causarle moretones o sangrado fácil.

Dígale a su médico todas las medicinas que usa, y cualquiera que comience o deje de usar, especialmente:

un anticoagulante (warfarin, Coumadin, Jantoven);

medicamento para el corazón o la presión arterial, incluyendo un diurético o "pastilla para eliminar el agua";

otras formas de diclofenac (Flector, Pennsaid, Solaraze, Voltaren Gel);

otros AINEs--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib (Celebrex), indomethacin, meloxicam, y otras; o

medicina esteroide (prednisone y otros).

Esta lista no está completa. Otras drogas pueden interactuar con diclofenac, incluyendo medicinas que se obtienen con o sin receta, vitaminas, y productos herbarios. No todas las interacciones posibles aparecen en esta guía del medicamento.

¿Dónde puedo obtener más información?

Su farmacéutico le puede dar información acerca de diclofenac.

Recuerde, mantenga ésta y todas las otras medicinas fuera del alcance de los niños, no comparta nunca sus medicinas con otros, y use este medicamento sólo para la condición por la que fue recetada.

Se ha hecho todo lo posible para que la información que proviene de Cerner Multum, Inc. ('Multum') sea precisa, actual, y completa, pero no se hace garantía de tal. La información sobre el medicamento incluida aquí puede tener nuevas recomendaciones. La información preparada por Multum se ha creado para uso del profesional de la salud y para el consumidor en los Estados Unidos de Norteamérica (EE. UU.) y por lo cual Multum no certifica que el uso fuera de los EE. UU. sea apropiado, a menos que se mencione específicamente lo cual. La información de Multum sobre drogas no sanciona drogas, ni diagnóstica al paciente o recomienda terapia. La información de Multum sobre drogas sirve como una fuente de información diseñada para la ayuda del profesional de la salud licenciado en el cuidado de sus pacientes y/o para servir al consumidor que reciba este servicio como un suplemento a, y no como sustituto de la competencia, experiencia, conocimiento y opinión del profesional de la salud. La ausencia en éste de una advertencia para una droga o combinación de drogas no debe, de ninguna forma, interpretarse como que la droga o la combinación de drogas sean seguras, efectivas, o apropiadas para cualquier paciente. Multum no se responsabiliza por ningún aspecto del cuidado médico que reciba con la ayuda de la información que proviene de Multum. La información incluida aquí no se ha creado con la intención de cubrir todos los usos posibles, instrucciones, precauciones, advertencias, interacciones con otras drogas, reacciones alérgicas, o efectos secundarios. Si usted tiene alguna pregunta acerca de las drogas que está tomando, consulte con su médico, enfermera, o farmacéutico.

Copyright 1996-2012 Cerner Multum, Inc. Version: 14.03. Revision Date: 1/13/2016 2:28:56 PM.

Antibiotics Buy Flagyl Er At, Strazyl

Antibiotics

Flagyl ER (Strazyl)

Flagyl ER is used for treating certain bacterial infections of the vagina (bacterial vaginosis). Flagyl ER is an oral antiprotozoal and antibacterial. It is thought to work by entering the bacterial cell, acting on some components of the cell, and destroying the bacteria.

Use Flagyl ER as directed by your doctor.

Take Flagyl ER by mouth on an empty stomach at least 1 hour before or 2 hours after eating.

Swallow Flagyl ER whole. Do not break, crush, or chew before swallowing.

To clear up your infection completely, take Flagyl ER for the full course of treatment. Keep taking it even if you feel better in a few days.

If you miss a dose of Flagyl ER, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Flagyl ER.

Store Flagyl ER at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Flagyl ER out of the reach of children and away from pets.

Active Ingredient: Metronidazole.

Do NOT use Flagyl ER if:

you are allergic to any ingredient in Flagyl ER or to another nitroimidazole (eg, tinidazole)

you are in the first trimestr of pregnancy

you are taking busulfan, an ergot alkaloid (eg, ergotamine), or you have taken disulfiram within the past 2 weeks

you are taking an HIV protease inhibitor that contains alcohol (eg, amprenavir solution); check with your pharmacist if you are unsure if the medicine contains alcohol

you drink alcohol.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Flagyl ER. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have nerve, brain, or blood problems; Crohn disease; or a history of liver problems or seizures.

Some medicines may interact with Flagyl ER. Tell your health care provider if you are taking any other medicines, especially any of the following:

Disulfiram because side effects, such as mental or mood changes, may occur

Amiodarone because the risk of irregular heartbeat may be increased

Barbiturates (eg, phenobarbital) or phenytoin because they may decrease Flagyl ER's effectiveness

Anticoagulants (eg, warfarin), busulfan, cyclosporine, ergot alkaloids (eg, ergotamine), HIV protease inhibitors containing alcohol (eg, amprenavir solution ), lithium, or macrolide immunosuppressants (eg, tacrolimus) because the risk of their side effects may be increased by Flagyl ER.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Flagyl ER may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Flagyl ER may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Flagyl ER with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

Do not drink alcohol while you are taking Flagyl ER and for at least 3 days after the last dose.

Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.

Flagyl ER only works against bacteria; it does not treat viral infections (eg, the common cold).

Be sure to use Flagyl ER for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.

Long-term or repeated use of Flagyl ER may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.

Flagyl ER may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Flagyl ER.

Lab tests, including liver function and white blood cell counts, may be performed while you use Flagyl ER. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Flagyl ER with caution in the elderly; they may be more sensitive to its effects.

Flagyl ER should be used with extreme caution in children; safety and effectiveness in children have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Flagyl ER while you are pregnant. Do not use Flagyl ER in the first 3 months of pregnancy. Flagyl ER is found in breast milk. Do not breastfeed while taking Flagyl ER.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Appetite loss; constipation; diarrhea; dizziness; headache; metallic taste; nausea; stomach upset; vomiting.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools; decreased coordination; increased or decreased urination; numbness, tingling, or burning of the arms, hands, legs, or feet; red, swollen, blistered, or peeling skin; seizures; severe diarrhea; severe or persistent dizziness or headache; sore throat, chills, or fever; speech problems; stiff neck; stomach pain or cramps; vaginal itching, odor, or discharge; vision loss or other vision changes; white patches in the mouth.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Your order will be packed safely and secure and dispatched within 24 hours. This is how your parcel will look like, the images are photographs of real shipments. It has the size of a normal protected envelope and it does not disclose its contents.

Also you may like:

Fluoxetine - Brand Name List From, Serotyl

Fluoxetine

See also.

Disclaimer: The indications, uses and warnings for individual medications outside the USA are determined by local regulatory bodies in each country or region. The Drugs. com website is intended primarily for audiences in the United States and its territories. Indications, uses and warnings on Drugs. com patient information leaflets are derived from FDA product labels and may differ in countries outside the USA. Every effort has been made to ensure that the information provided on this page is accurate, up-to-date and complete, but no guarantee is made to that effect. Drugs. com does not endorse drugs, diagnose patients or recommend specific therapies. The information on this page is not a substitute for the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that a drug or drug combination is safe, effective or appropriate for any given patient. Drugs. com does not assume any responsibility for any aspect of healthcare administered with the aid of information provided here. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Always consult your doctor or healthcare specialist for medical advice.

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Coracten, Coracten

Coracten

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Coracten

nicotine transdermal system

Adalat CC, Adalat LA (UK), Adalat P. A. Adalat Retard (UK), Adalat XL, Adipine (UK), Afeditab CR, Angiopine (UK), Apo-Nifed, Calchan (UK), Cardilate MR (UK), Coracten (UK), Fortipine (UK), Gen-Nifedical, Hypolar Retard (UK), Neozipine XL (UK), Nifediac CC, Nifedical XL, Nifedipress MR (UK), Nifopress MR (UK), Novo-Nifedin, Nu-Nifed, Procardia, Procardia XL, Slofedipine (UK), Tensipine (UK), Valni Retard (UK), Valni XL (UK)TasignaAnandron, NilandronNimotopSular, Syscor (UK)AliniaApo-Nitrofurantoin, Furadantin, Novo-Furantoin

Pharmacologic class: Cholinergic

Therapeutic class: Smoking deterrent

Pregnancy risk category C (gum), D (inhalation, nasal, transdermal)

Pregnancy risk category C (gum), D (inhalation, nasal, transdermal)

Pharmacologic class: Calcium channel blocker

Therapeutic class: Antianginal, anti-hypertensive

Pregnancy risk category C

Pharmacologic class: Protein-tyrosine kinase inhibitor

Therapeutic class: Antineoplastic

Pregnancy risk category D

Pharmacologic class: Antiandrogen

Therapeutic class: Antineoplastic

Pregnancy risk category C

Pharmacologic class: Calcium channel blocker

Therapeutic class: Cerebral vasodilator

Pregnancy risk category C

Pharmacologic class: Antiprotozoal

Therapeutic class: Anti-infective

Pregnancy risk category B

FDA Box Warning

Drug prolongs QT interval and may lead to sudden death. Don't give to patients with hypokalemia, hypomagnesemia, or long-QT syndrome. Correct hypokalemia or hypomagnesemia before starting drug and monitor for these imbalances periodically. Avoid concomitant drugs known to prolong QT interval; also avoid strong CYP3A4 inhibitors. Instruct patient not to eat 2 hours before or 1 hour after taking dose. Obtain ECG to monitor QTc at baseline, 7 days after drug initiation, periodically thereafter, and after dosage adjustments.

Reduce dosage in patients with hepatic impairment.

Action

Supplies nicotine during controlled withdrawal from cigarette smoking. Binds selectively to nicotinic-choliner-gic receptors in central and peripheral nervous systems, autonomic ganglia, adrenal medulla, and neuromuscular junction. At low doses, has a stimulating effect; at high doses, a reward effect.

Availability

Chewing gum: 2 mg, 4 mg

Inhalation: 42 cartridges/system, each containing 10 mg nicotine (delivers 4 mg)

Nasal spray: 10 mg/ml (0.5 mg/spray) in 10-ml bottles (100 doses)

Transdermal patch: 7 mg/day, 11 mg/day, 14 mg/day, 15 mg/day, 21 mg/day, 22 mg/day

⊘ Indications and dosages

➣ Adjunctive therapy (with behavior modification) for nicotine withdrawal Transdermal system -

Adults: 21 mg/day transdermally (Habitrol) for 4 to 8 weeks, then 14 mg/day for 2 to 4 weeks, then 7 mg/day for 2 to 4 weeks, for a total of 8 to 16 weeks; patient must wear system 24 hours/day. Or 21 mg/day transdermally (Nicoderm CQ) for 6 weeks, then 14 mg/day for 2 weeks, then 7 mg/day for 2 weeks, for a total of 10 weeks; patient must wear system 24 hours/day. Or 15 mg/day transdermally (one Nicotrol patch) for 6 weeks; patient must wear system 16 hours/day, removing it at bedtime.

Adults, adolescents, and children weighing less than 45 kg (100 lb) who smoke fewer than 10 cigarettes daily or have underlying cardiovascular disease: 14 mg/day transdermally (Habitrol) for 4 to 8 weeks, then 7 mg/day for 2 to 4 weeks, for a total of 6 to 8 weeks; patient must wear system 24 hours/day. Or 14 mg/day transdermally (Nicoderm CQ) for 6 weeks, then 7 mg/day for 2 weeks, for a total of 8 weeks; patient must wear system 24 hours/day. Nasal spray -

Adults: One spray intranasally in each nostril once or twice per hour, up to five times per hour or 40 times per day, for no longer than 6 months Inhalation -

Adults: For optimal response, at least six cartridges inhaled daily for first 3 to 6 weeks, to a maximum of 16 cartridges daily for up to 12 weeks. Patient self-titrates dosage to required nicotine level (usually 6 to 16 cartridges daily), followed by gradual withdrawal over 6 to 12 weeks.

Adults: Use as needed depending on smoking urge or chewing rate, or use on fixed schedule q 1 to 2 hours. Initial requirement may range from 18 to 48 mg/day, not to exceed 60 mg/day.

Contraindications

• Hypersensitivity to drug or its components or to menthol (inhaler only) • Allergy to adhesive (transdermal forms only)

Precautions

Use cautiously in: • cardiovascular disease, hypertension, bronchospastic disease, diabetes mellitus, pheochromocytoma, peripheral vascular disease, hyperthyroidism, peptic ulcer disease, hepatic disease • immediately after myocardial infarction, severe arrhythmia, or severe or worsening angina (use not recommended) • skin disorders (transdermal form) • dental disorders, esophagitis, pharyngitis, stomatitis (gum form) • females of childbearing age • pregnant or breastfeeding patients. • children under age 18 (safety and efficacy not established).

Administration

• Apply patch when patient awakens and remove patch (as prescribed) at same time each day. • Administer nasal spray regularly during first week, to help patient get used to irritant effects. • With inhalation use, give at least six cartridges daily for first 3 to 6 weeks. • Encourage patient to titrate dosage to level required, followed by gradual withdrawal.

Adverse reactions

CNS: headache, dizziness, drowsiness, poor concentration, nervousness, weakness, paresthesia, insomnia, abnormal dreams

CV: chest pain, hypertension, tachycardia, atrial fibrillation

EENT: sinusitis; pharyngitis (with gum); mouth and throat irritation (with inhaler); nasopharyngeal irritation, rhinitis, sneezing, watering eyes, eye irritation (with nasal spray)

GI: nausea, vomiting, diarrhea, constipation, abdominal pain, dry mouth, dyspepsia; increased salivation, sore mouth (with gum)

Musculoskeletal: joint pain, back pain, myalgia; jaw ache (with gum)

Respiratory: increased cough (with nasal spray or inhaler), bronchospasm

Skin: burning at patch site, erythema, pruritus, cutaneous hypersensitivity, rash, sweating (all with transdermal patch)

Other: abnormal taste, increased appetite (with gum), allergy, hiccups

Interactions

Drug-drug. Acetaminophen, adrenergic antagonists (such as prazosin, labetalol), clozapine, furosemide, imipramine, oxazepam, pentazocine, propranolol and other beta-adrenergic blockers, theophylline: increased effects of these drugs

Bupropion: treatment-emergent hypertension

Insulin: decreased insulin requirement

Isoproterenol, phenylephrine: increased requirements for these drugs

Propoxyphene: decreased nicotine metabolism

Drug-food. Caffeine-containing foods and beverages: increased nicotine effects

Drug-behaviors. Cigarette smoking: increased nicotine metabolism and effects

Patient monitoring

• Assess for signs and symptoms of nicotine withdrawal (irritability, drowsiness, fatigue, headache).

Watch for bronchospasm and evidence of nicotine toxicity (nausea, vomiting, diarrhea, increased salivation, headache, dizziness, visual disturbances).

Patient teaching

Caution patient against any type of smoking during therapy. Urge him to immediately report chest tightness or difficulty breathing. • If patient uses gum, advise him to chew one piece whenever nicotine craving occurs. Instruct him to chew it slowly until he feels a tingling sensation, then store it between cheek and gum until tingling disappears. • Instruct patient to apply transdermal patch to clean, dry skin of upper arm or torso when he awakens; to keep it in place when showering, bathing, or swimming; and to remove it at same time each day. • If patient uses nasal spray, instruct him to tilt head back slightly when spraying. Remind him not to sniff, swallow, or inhale through nose. • If patient uses inhalation form, teach him to puff continuously for 20 minutes and to use at least six cartridges daily for first 3 to 6 weeks. • As appropriate, review all significant and life-threatening adverse reactions and interactions, especially those related to the drugs, foods, and behaviors mentioned above.

nifedipine

Adalat CC, Adalat LA (UK). Adalat P. A. Adalat Retard (UK). Adalat XL, Adipine (UK). Afeditab CR, Angiopine (UK). Apo-Nifed, Calchan (UK). Cardilate MR (UK). Coracten (UK). Fortipine (UK). Gen-Nifedical, Hypolar Retard (UK). Neozipine XL (UK). Nifediac CC, Nifedical XL, Nifedipress MR (UK). Nifopress MR (UK). Novo-Nifedin, Nu-Nifed, Procardia, Procardia XL, Slofedipine (UK). Tensipine (UK). Valni Retard (UK). Valni XL (UK)

Pharmacologic class: Calcium channel blocker

Therapeutic class: Antianginal, anti-hypertensive

Pregnancy risk category C

Action

Inhibits calcium transport into myocardial and vascular smooth muscle cells, suppressing contractions. Dilates main coronary arteries and arterioles and inhibits coronary artery spasm, increasing oxygen delivery to heart and decreasing frequency and severity of angina attacks.

Availability

Capsules: 5 mg, 10 mg, 20 mg

Tablets (extended-release): 10 mg, 20 mg, 30 mg, 60 mg, 90 mg

⊘ Indications and dosages

➣ Vasospastic (Prinzmetal's) angina; chronic stable angina

Adults: Initially, 10 mg P. O. (immediate-release) t. i.d. titrated over 7 to 14 days; usual effective range is 10 to 20 mg t. i.d. not to exceed 180 mg/day. Patient may be switched to extended-release at nearest equivalent of immediate-release daily dosage (for instance, 30-mg immediate-release dose may be switched to 90-mg extended-release dose). Total extended-release dosage should not exceed 90 mg/day.

Adults: 30 to 60 mg/day P. O. (extended-release only) titrated over 7 to 14 days to a maximum of 120 mg/day

Off-label uses

• Aortic regurgitation • Heart failure • Migraine • Prevention of labor

Contraindications

• Hypersensitivity to drug

Precautions

Use cautiously in: • chronic renal insufficiency • hypotension, aortic stenosis, heart failure, significant left ventricular dysfunction (especially when used with beta-adrenergic blockers), peripheral edema • elderly patients • pregnant or breastfeeding patients (safety not established) • children (safety not established).

Administration

• Give immediate-release form with or without food. If GI upset occurs, give with meals, but never with grapefruit or grapefruit juice. • Don't crush or break extended-release tablet. Make sure patient swallows it whole. Give on empty stomach, and not with grapefruit or grapefruit juice. • Know that Procardia XL and Adalat CC are not equivalent because of their pharmacokinetic differences. • Be aware that only extended-release tablets are used to treat hypertension.

Adverse reactions

CNS: headache, dizziness, fatigue, asthenia, paresthesia, vertigo

CV: peripheral edema, chest pain, hypotension

EENT: epistaxis, rhinitis

GI: nausea, constipation

GU: urinary frequency, erectile dysfunction

Musculoskeletal: leg cramps

Skin: flushing, rash

Interactions

Drug-drug. Beta-adrenergic blockers: increased risk of heart failure, severe hypotension, or angina exacerbation

Cimetidine: increased nifedipine blood level

Coumarin anticoagulants: increased prothrombin time

Digoxin: increased risk of digoxin toxicity

Quinidine: decreased quinidine blood level

Drug-diagnostic tests. Antinuclear antibody, direct Coombs' test false-positive results

Drug-food. Grapefruit, grapefruit juice: increased nifedipine blood level and effects

Drug-herbs. Ephedra (ma huang), yohimbine: antagonism of nifedipine effect

Ginkgo, ginseng: increased nifedipine blood level

St. John's wort: decreased nifedipine blood level

Drug-behaviors. Alcohol use: additive hypotension

Patient monitoring

• Monitor vital signs and cardiovascular status. Stay alert for chest pain and edema. • Watch for rash.

Patient teaching

• Tell patient he may take immediate-release form with or without meals. If GI upset occurs, tell him to take it with meals, but never with grapefruit or grapefruit juice. • Caution patient not to crush or break extended-release tablets. Tell him to swallow them whole. Advise him to take on empty stomach, and not with grapefruit or grapefruit juice. • Inform patient that angina attacks may occur 30 minutes after a dose. Explain that these attacks are usually temporary and don't mean that drug should be withdrawn.

Tell patient to report rash immediately. • Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration, balance, and alertness. • Instruct patient to consult prescriber before taking herbs or over-the-counter drugs (especially cold remedies). • As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs, tests, foods, herbs, and behaviors mentioned above.

nilotinib

Pharmacologic class: Protein-tyrosine kinase inhibitor

Therapeutic class: Antineoplastic

Pregnancy risk category D

FDA BOXED WARNING

Drug prolongs QT interval and may lead to sudden death. Don't give to patients with hypokalemia, hypomagnesemia, or long-QT syndrome. Correct hypokalemia or hypomagnesemia before starting drug and monitor for these imbalances periodically. Avoid concomitant drugs known to prolong QT interval; also avoid strong CYP3A4 inhibitors. Instruct patient not to eat 2 hours before or 1 hour after taking dose. Obtain ECG to monitor QTc at baseline, 7 days after drug initiation, periodically thereafter, and after dosage adjustments.

Reduce dosage in patients with hepatic impairment.

Action

Inhibits proliferation of murine leukemic cell lines mediated by BCR-ABL kinase and human cell lines derived from patients with Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML)

Availability

Capsules: 200 mg

⊘ Indications and dosages

➣ Chronic-phase or accelerated-phase Ph+ CML in patients resistant or intolerant to previous imatinib therapy

Adults: 400 mg P. O. q 12 hours

➣ Newly diagnosed Philadelphia chromosome positive CML Adults: 300 mg P. O. q 12 hours

Dosage adjustment

• QTc longer than 480 msec • Hematologic toxicity • Moderate or severe non-hematologic toxicity • Concomitant use of CYP3A4 inducers • Hepatic impairment

Off-label uses

• Ph+ acute lymphoblastic leukemia (ALL) • Systemic mastocytosis with c-kit receptor activation • Hypereosinophilic syndrome

Contraindications

• Hypokalemia • Hypomagnesemia • Long-QT syndrome

Precautions

Use cautiously in: • hepatic impairment • rare hereditary problems of galactose intolerance, severe lactase deficiency, or glucose-galactose malabsorption (use not recommended) • myelosuppression • electrolyte abnormalities • history of pancreatitis • pregnant or breastfeeding patients • children (safety and efficacy not established).

Administration

Correct hypophosphatemia and hypokalemia before starting drug. • Don't give with food. Know that patient shouldn't consume food for at least 2 hours before or 1 hour after dose. • Administer capsule whole with water. • Be aware that drug may be given in combination with hematopoietic growth factors, if indicated.

Adverse reactions

CNS: headache, fatigue, asthenia, insomnia, dizziness, paresthesia, vertigo, intracranial hemorrhage

CV: palpitations, hypertension, flushing, QT interval prolongation and sudden death

EENT: dysphonia, nasopharyngitis

GI: nausea, vomiting, diarrhea, constipation, abdominal pain, abdominal discomfort, dyspepsia, flatulence, anorexia

Hematologic: anemia, neutropenia, thrombocytopenia, leukopenia, pan-cytopenia, febrile neutropenia

Metabolic: electrolyte abnormalities

Musculoskeletal: arthralgia, myalgia, extremity pain, bone pain, muscle spasms, back pain, chest pain

Respiratory: cough, dyspnea, exertional dyspnea, pneumonia

Skin: rash, pruritus, eczema, urticaria, alopecia, erythema, hyperhidrosis, dry skin

Other: fever, peripheral edema, night sweats, weight changes

Interactions

Drug-drug. Drugs eliminated by CYP2B6, CYP2C8, or CYP2C9: decreased blood levels of these drugs

Drugs eliminated by CYP3A4 (such as warfarin), CYP2C8, CYP2C9, CYP2D6, or UGT1A1: increased blood levels of these drugs

Drugs that inhibit P-glycoprotein

ABCB1: increased nilotinib blood level

Midazolam: increased midazolam exposure

P-glycoprotein substrates: increased blood levels of these drugs

Strong CYP3A4 inducers (such as carba-mazepine, dexamethasone, phenytoin, rifabutin, rifampin, rifapentin, phenobarbital): decreased nilotinib blood level

Strong CYP3A4 inhibitors (such as atazanavir, clarithromycin, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin, voriconazole): increased nilotinib blood level

Drug-diagnostic tests. Albumin, calcium, magnesium, neutrophils, phosphorus, platelets, sodium, white blood cells: decreased levels

ALP, ALT, AST, bilirubin, blood glucose, creatinine, serum amylase, serum lipase: increased levels

Potassium: increased or decreased level

Drug-food. Grapefruit products: increased nilotinib blood level

High-fat meal: increased nilotinib onset

Drug-herbs. St. John's wort: decreased nilotinib blood level

Patient monitoring

Closely monitor for prolonged QT interval if patient has hepatic impairment or is receiving strong CYP3A4 inhibitors. • Obtain complete blood count every 2 weeks for first 2 months of therapy and monthly thereafter, or as indicated. • Periodically monitor electrolyte and lipase levels and liver function tests.

Patient teaching

• Tell patient not to take drug with food and not to consume food for at least 2 hours before or 1 hour after dose. • Advise patient to take capsules whole with water.

Instruct patient to avoid grapefruit products and St. John's wort. • Tell lactose-intolerant patient that drug contains lactose.

Instruct patient to immediately notify prescriber if symptoms of QTc prolongation (faintness or irregular heartbeat) occur.

Urge patient to immediately report signs or symptoms of liver damage, such as nausea, fatigue, anorexia, yellowing of skin or eyes, dark urine, light-colored stools, itching, or abdominal tenderness. • Advise female patient that drug may harm fetus. Caution her to avoid pregnancy. • Advise breastfeeding patient to seek guidance to help her decide whether to discontinue breastfeeding or discontinue drug. • As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, food, and herbs mentioned above.

nilutamide

Pharmacologic class: Antiandrogen

Therapeutic class: Antineoplastic

Pregnancy risk category C

FDA BOXED WARNING

Drug may cause interstitial pneumonitis. Though rare, interstitial changes have led to hospitalization and death postmarketing. Most cases occurred within first 3 months of therapy and reversed after drug was stopped. Obtain routine chest X-ray before starting treatment, and be prepared to obtain baseline pulmonary function tests if ordered. Instruct patient to report new or worsening shortness of breath; this symptom warrants immediate drug withdrawal pending evaluation.

Action

Inhibits testosterone uptake in target tissue, preventing normal androgenic response and arresting tumor growth in androgen-sensitive tissue

Availability

Tablets: 50 mg, 150 mg

⊘ Indications and dosages

➣ Metastatic prostate cancer (used with surgical castration)

Adults: 300 mg/day P. O. for 30 days, starting on day of or day after surgery; then 150 mg/day P. O.

Contraindications

• Hypersensitivity to drug or its components • Severe hepatic or respiratory insufficiency

Precautions

Use cautiously in: • renal impairment.

Administration

• Give with or without food. • Start therapy on same day as or day after surgical castration.

Adverse reactions

CNS: dizziness, depression, hyperes-thesia, insomnia

CV: hypertension, peripheral edema, heart failure

EENT: abnormal vision, impaired dark and light adaptation, chromatopsia

GI: nausea, vomiting, constipation, dyspepsia, anorexia

GU: hematuria, nocturia, urinary tract infection, gynecomastia, testicular atrophy, decreased libido, erectile dysfunction

Hematologic: anemia, aplastic anemia

Respiratory: dyspnea, upper respiratory infection, interstitial pneumonia

Other: flulike symptoms, pain, fever, hot flushes, alcohol intolerance

Interactions

Drug-drug. Phenytoin, theophylline, vitamin K: increased risk of toxicity from these drugs

Drug-diagnostic tests. Alanine aminotransferase, aspartate aminotransferase: increased levels

Drug-behaviors. Alcohol use: disulfiram-like reaction

Patient monitoring

• Check for signs and symptoms of hepatitis. Monitor liver function tests. • Monitor CBC. • Assess fluid intake and output and weight. Watch for signs and symptoms of heart failure. • Monitor respiratory status, including chest X-rays.

Patient teaching

• Advise patient he may take with or without food. • Tell patient therapy will start on day of or day after surgical castration. • Caution patient not to stop taking drug without consulting prescriber. • Instruct patient to weigh himself daily and report sudden increases.

Advise patient to report new onset or worsening of dyspnea as well as signs and symptoms of hepatotoxicity, such as nausea, vomiting, abdominal pain, unusual tiredness, or yellowing of skin or eyes. • Advise patient to avoid alcohol during therapy, because serious adverse reactions may occur. • Tell patient drug may impair his adaptation to darkness and light, which may cause difficulty driving at night or through tunnels. • As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, test, and behaviors mentioned above.

nimodipine

Pharmacologic class: Calcium channel blocker

Therapeutic class: Cerebral vasodilator

Pregnancy risk category C

FDA BOXED WARNING

Don't give by I. V. or other parenteral route. Deaths and serious or life-threatening adverse events have occurred when capsule contents have been injected parenterally.

Action

Inhibits calcium transport into vascular smooth muscle cells, suppressing contractions; also dilates coronary and cerebral arteries

Availability

⊘ Indications and dosages

➣ Subarachnoid hemorrhage

Adults: 60 mg P. O. q 4 hours for 21 days. Therapy should start within 96 hours of subarachnoid hemorrhage.

Dosage adjustment

• Hepatic impairment

Contraindications

Precautions

Use cautiously in: • hepatic impairment, hypotension • elderly patients • pregnant or breastfeeding patients (safety not established) • children (safety not established).

Administration

• Give at least 1 hour before or 2 hours after meals. Don't let patient consume grapefruit or grapefruit juice within 1 hour before or 2 hours after dose. • If patient can't swallow capsule, puncture it with sterile needle and empty contents into syringe. Administer through nasogastric tube, then flush with normal saline solution (30 ml).

Adverse reactions

CNS: headache, depression

CV: hypotension, peripheral edema, ECG abnormalities, bradycardia, tachycardia

GI: nausea, diarrhea, abdominal discomfort

Musculoskeletal: muscle cramps

Skin: acne, flushing, rash

Interactions

Drug-drug. Other calcium channel

blockers: enhanced cardiovascular effects

Drug-diagnostic tests. Liver function

tests: abnormal results

Drug-food. Any food: decreased drug blood level and effects

Grapefruit juice, grapefruit juice: increased drug blood level and effects

Drug-herbs. Ephedra (ma huang) ,

yohimbine: antagonism of nimodipine effects

St. John's wort: decreased drug blood level

Drug-behaviors. Alcohol use: increased hypotension

Patient monitoring

• Monitor weight and fluid intake and output. Stay alert for fluid retention. • Assess neurologic status and mood, watching for signs of depression. • Check vital signs and ECG.

Patient teaching

• Tell patient to complete full course of therapy (21 days). • Advise patient to take on an empty stomach 1 hour before or 2 hours after a meal. Instruct him to not to consume grapefruit or grapefruit juice within 1 hour before or 2 hours after taking drug. • Tell patient to report irregular heartbeat, shortness of breath, rash, or swollen hands or feet. • Instruct patient to minimize GI upset by eating small, frequent meals. • Advise patient to weigh himself daily and report sudden weight gain. • As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs, tests, foods, herbs, and behaviors mentioned above.

nisoldipine

Sular, Syscor (UK)

Pharmacologic class: Calcium channel blocker

herapeutic class: Antihypertensive

Pregnancy risk category C

Action

Suppresses calcium transport into vascular smooth muscle cells. This suppression inhibits vasoconstriction and dilates coronary arteries, improving myocardial oxygen uptake.

Availability

Tablets (extended-release): 8.5 mg, 17 mg, 22.5 mg, 34 mg

⊘ Indications and dosages

Adults: Initially, 17 mg P. O. daily; may increase by 8.5 mg per week or longer intervals to attain adequate blood pressure control. Usual maintenance dosage is 17 to 34 mg daily.

Contraindications

• Hypersensitivity to drug or dihydropyridine calcium channel blockers

Precautions

Use cautiously in: • heart failure and left ventricular dysfunction, hepatic impairment, renal disease, coronary artery disease, hypotension • concurrent phenytoin use • elderly patients • pregnant or breastfeeding patients • children (safety not established).

Administration

• Give with meals, but not with high-fat meals, grapefruit, or grapefruit juice. • Don't crush or break extended-release tablets. Make sure patient swallows them whole. • Know that drug may be given alone or with other antihypertensives.

Adverse reactions

CNS: headache, dizziness

CV: peripheral edema, chest pain, vasodilation, hypotension, palpitations

EENT: pharyngitis, sinusitis

Interactions

Drug-drug. Cimetidine: increased nisoldipine blood level

Phenytoin, other CYP3A4 inducers: decreased nisoldipine blood level and efficacy

Drug-food. Grapefruit juice: significantly increased drug blood level and effects

High-fat meal: decreased drug blood level

Drug-herbs. Ephedra (ma huang), yohimbine: antagonism of nimodipine effects

St. John's wort: decreased nimodipine blood level

Drug-behaviors. Alcohol use: increased hypotensive effects

Patient monitoring

• Check vital signs and ECG. • Monitor fluid intake and output. Watch for peripheral edema.

Patient teaching

• Tell patient to swallow extended-release tablets whole and not to crush or break them. • Advise patient to take with food, but not high-fat food. Recommend small, frequent meals. • Instruct patient to avoid high-fat meals, alcohol, grapefruit, and grapefruit juice. • Tell patient to immediately report irregular heart beat, shortness of breath, swelling, pronounced dizziness, rash, or chest pain. • As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs, foods, herbs, and behaviors mentioned above.

nitazoxanide

Pharmacologic class: Antiprotozoal

Therapeutic class: Anti-infective

Pregnancy risk category B

Action

Impedes pyruvate:ferredoxin oxidoreductase enzyme-dependent electron transfer reaction, which is essential to anaerobic energy metabolism

Availability

Oral suspension: 100 mg/5 ml

⊘ Indications and dosages

➣ Diarrhea caused by Giardia lamblia or Cryptosporidium parvum

Adults and children ages 12 and older: 500 mg (tablet or 25 ml suspension) P. O. every 12 hours with food for 3 days

Children ages 4 to 11 . 200 mg (10 ml suspension) P. O. every 12 hours with food for 3 days

Children ages 1 to 3: 100 mg (5 ml suspension) P. O. every 12 hours with food for 3 days

Contraindications

• Hypersensitivity to drug or its components

Precautions

Use cautiously in: • renal, hepatic, or biliary disease or dysfunction; immunodeficiency (including human immunodeficiency virus); diabetes mellitus (suspension) • concurrent use of warfarin or other highly plasma protein-bound drugs • elderly patients • pregnant or breastfeeding patients • children younger than age 11 (tablets) or age 1 (suspension).

Administration

• Give with food. • Because a single tablet contains more nitazoxanide than recommended for pediatric dosing, don't give tablets to children younger than age 11. • Keep suspension container tightly closed and shake well before each use. Suspension may be stored for 7 days; after that, discard unused portion.

Adverse reactions

GI: nausea, vomiting, diarrhea, abdominal pain

Interactions

Drug-drug. Warfarin and other highly plasma protein-bound drugs with narrow therapeutic index: competition for binding sites, resulting in increased nitazoxanide blood level and efficacy

Patient monitoring

• Monitor renal and liver function tests frequently in patients with renal, hepatic, or biliary dysfunction. • Monitor blood glucose levels in diabetic patients taking oral suspension.

Patient teaching

• Instruct patient to take drug with food. • Inform diabetic patient that oral suspension contains sucrose. • As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs mentioned above.

nitrofurantoin

Apo-Nitrofurantoin, Furadantin, Novo-Furantoin

Coracten

Metoprolol Medlineplus Medicinas, Meprolol

Metoprolol

No deje de tomar el metoprolol sin consultar a su medico. Dejar de tomar el metoprolol de forma repentina puede provocar dolor de pecho o ataque cardiaco. Es probable que el medico opte por disminuir gradualmente la dosis.

?Para cuales condiciones o enfermedades se prescribe este medicamento?

El metoprolol se usa solo o en combinacion con otros medicamentos para tratar la presion arterial alta. Tambien se usa para prevenir la angina de pecho (dolor en el pecho) y para tratar los ataques cardiacos. El metoprolol se usa tambien en combinacion con otros medicamentos, para tratar la insuficiencia cardiaca. El metoprolol pertenece a una clase de medicamentos llamados bloqueadores beta. Funciona al relajar los vasos sanguineos y la disminucion de la frecuencia cardiaca para mejorar el flujo sanguineo y disminuir la presion arterial.

La hipertension arterial es una condicion comun y cuando no se trata, puede causar danos en el cerebro, el corazon, los vasos sanguineos, los rinones y otras partes del cuerpo. El dano a estos organos puede causar enfermedades del corazon, un infarto, insuficiencia cardiaca, apoplejia, insuficiencia renal, perdida de la vision y otros problemas. Ademas de tomar medicamentos, hacer cambios de estilo de vida tambien le ayudara a controlar su presion arterial. Estos cambios incluyen comer una dieta que sea baja en grasa y sal, mantener un peso saludable, hacer ejercicio al menos 30 minutos casi todos los dias, no fumar y consumir alcohol con moderacion.

?Como se debe usar este medicamento?

Las presentaciones del metoprolol son tabletas normales y tabletas de liberacion prolongada (accion prolongada) para administrarse por via oral. En general, las tabletas normales se toman una o dos veces al dia, con las comidas o inmediatamente despues de estas. Por lo comun, las tabletas de liberacion prolongada se toman una vez al dia. Para que no olvide tomar el metoprolol, tomelo aproximadamente a la misma hora todos los dias. Siga atentamente las instrucciones de la receta y pidales a su medico o a su farmaceutico que le expliquen cualquier cosa que no entienda. Tome el metoprolol exactamente segun lo indicado. No aumente ni disminuya la dosis, ni la tome con mas frecuencia que la indicada por su medico.

Las tabletas de accion prolongada pueden partirse. Trague las tabletas enteras o en mitades, pero no las mastique ni las triture.

Es posible que el medico le recete al principio una dosis baja de metoprolol y que, luego, la aumente de modo gradual.

El metoprolol controla la presion arterial alta y la angina (dolor en el pecho), pero no las cura. El metoprolol de liberacion prolongada controla la insuficiencia cardiaca, pero no la cura. Pueden pasar varias semanas antes de que sienta los beneficios totales del metoprolol. Siga tomando el metoprolol aunque se sienta bien.

?Que otro uso se le da a este medicamento?

El metoprolol tambien se usa a veces para prevenir la migrana, y para tratar los latidos cardiacos irregulares y los trastornos del movimiento ocasionados por los medicamentos para la enfermedad mental. Consulte a su medico sobre los posibles riesgos de usar este medicamento en su caso.

A veces se receta este medicamento para otros usos; pidales mas informacion a su medico o a su farmaceutico.

Super Gels - Scents, Pro-Cure

Super Gels

Super Gel has gotten more effective with the addition of UV enhancement. It's like attaching a lit light bulb to your lure or bait. The visibility brings fish in to investigate, and the scent gets them to feed. There is no other product on the market that even comes close to performing like Super Gel. Made from real bait and enhanced with powerful amino acids in a sticky base that sticks to lures, spoons, spinners, swim baits, soft baits, etc. for an exceptionally long time. Word of mouth has spread like wild fire, and in 26 years of making great products we've never had a product catch on like Super Gel. In both fresh and salt water formulas. Available in 2 oz. squeeze bottles or 8 oz. Guide Size squeeze bottles.

You can NOT inject gels with the bait injectors or the injector heads. The gel is too thick.

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Pure ground up anchovies. Perfect for swim baits, soft plastics, plugs, spoons, and stick baits. Learn More

Metrolag Generic Name Metronidazole Online, Metrolag

Metrolag General Information

Metrolag - Pharmacology:

Unionized metronidazole is selective for anaerobic bacteria due to their ability to intracellularly reduce metronidazole to its active form. This reduced metronidazole then disrupts DNA's helical structure, inhibiting bacterial nucleic acid synthesis and resulting in bacterial cell death.

Metrolag for patients

Patients using METROGEL O (metronidazole gel) 1% should receive the following information and instructions:

1. This medication is to be used as directed.

2. It is for external use only.

3. Avoid contact with the eyes.

4. Cleanse affected area(s) before applying METROGEL O (metronidazole gel) 1%.

5. This medication should not be used for any other condition than that for which it is prescribed.

6. Patients should report any adverse reaction to their physician.

This description is suitable for active ingredient Metronidazole

Metrolag Interactions

Oral metronidazole has been reported to potentiate the anticoagulant effect of coumarin and warfarin, resulting in a prolongation of prothrombin time. Drug interactions should be kept in mind when METROGEL O (metronidazole gel), 1% is prescribed for patients who are receiving anticoagulant treatment, although they are less likely to occur with topical metronidazole administration because of low absorption.

Metrolag Contraindications

METROGEL O (metronidazole gel), 1% is contraindicated in those patients with a history of hypersensitivity to metronidazole or to any other ingredient in this formulation.

This description is suitable for active ingredient Metronidazole

Generic name, Overdose, Half Life Metrolag, Food Interactions, Chemical, etc..

Metrolag see also

Omeprol, Omeprol

Omeprol

Important Notice: The Drugs. com international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

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Orapred Odt (Prednisolone Sodium Phosphate) Drug Information Indications, Dosage And How Supplied -

Orapred ODT (prednisolone sodium phosphate orally disintegrating tablet) is indicated in the treatment of the following diseases or conditions:

Allergic Conditions

Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment in adult and pediatric populations with:

Atopic dermatitis

Drug hypersensitivity reactions

Seasonal or perennial allergic rhinitis

Serum sickness

Dermatologic Diseases

Endocrine Conditions

Congenital adrenal hyperplasia

Hypercalcemia of malignancy

Nonsuppurative thyroiditis

Primary or secondary adrenocortical insufficiency: hydrocortisone or cortisone is the first choice; synthetic analogs may be used in conjunction with mineralocorricoids where applicable.

Gastrointestinal Diseases

During acute episodes in:

Hematologic Diseases

Neoplastic Conditions

For the treatment of:

Nervous System Conditions

Ophthalmic Conditions

Sympathetic ophthalmia

Uveitis and ocular inflammatory conditions unresponsive to topical corricosteroids

Conditions Related to Organ Transplantation

Acute or chronic solid organ rejection

Pulmonary Diseases

Acute exacerbations of chronic obstructive pulmonary disease (COPD)

Allergic bronchopulmonary aspergillosis

Aspiration pneumonitis

Asthma

Fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate chemotherapy

Hypersensitivity pneumonitis

Idiopathic bronchiolitis obliterans with organizing pneumonia

Idiopathic eosinophilic pneumonias

Idiopathic pulmonary fibrosis Pneumocystis carinii pneumonia (PCP) associated with hypoxemia occurring in an HIV (+) individual who is also under treatment with appropriate anti-PCP antibiotics

Symptomatic sarcoidosis

Renal Conditions

To induce a diuresis or remission of proteinuria in nephrotic syndrome, without uremia. of the idiopathic type or that due to lupus erythematosus

Rheumatologic Conditions

Specific Infectious Diseases

Trichinosis with neurologic or myocardial involvement

Tuberculous meningitis with subarachnoid block or impending block, (used concurrently with appropriate antituberculous chemotherapy

DOSAGE AND ADMINISTRATION

Recommended Dosing

Dosage of Orapred ODT (prednisolone sodium phosphate) should be individualized according to the severity of the disease and the response of the patient. For pediatric patients, the recommended dosage should be governed by the same considerations rather than strict adherence to the ratio indicated by age or body weight.

Do not break or use partial Orapred ODT (prednisolone sodium phosphate) tablets. Use an appropriate formulation of prednisolone if indicated dose cannot be obtained using Orapred ODT. This may become important in the treatment of conditions that require tapering doses that cannot be adequately accommodated by Orapred ODT (prednisolone sodium phosphate). e. g. tapering the dose below 10 mg.

The initial dose of Orapred ODT (prednisolone sodium phosphate) may vary from 10 to 60 mg (prednisolone base) per day, depending on the specific disease entity being treated. In situations of less severity, lower doses will generally suffice while in selected patients higher initial doses may be required. The initial dosage should be maintained or adjusted until a satisfactory response is noted. If after a reasonable period of time, there is a lack of satisfactory clinical response, Orapred should be discontinued and the patient placed on other appropriate therapy. IT SHOULD BE EMPHASIZED THAT DOSAGE REQUIREMENTS ARE VARIABLE AND MUST BE INDIVIDUALIZED ON THE BASIS OF THE DISEASE UNDER TREATMENT AND THE RESPONSE OF THE PATIENT. After a favorable response is noted, the proper maintenance dosage should be determined by decreasing the initial drug dosage in small decrements at appropriate time intervals until the lowest dosage that will maintain an adequate clinical response is reached. It should be kept in mind that constant monitoring is needed in regard to drug dosage. Included in the situations which may make dosage adjustments necessary are changes in clinical status secondary to remissions or exacerbations in the disease process, the patient's individual drug responsiveness, and the effect of patient exposure to stressful situations not directly related to the disease entity under treatment; in this latter situation it may be necessary to increase the dosage of Orapred ODT (prednisolone sodium phosphate) for a period of time consistent with the patient's condition. If after long term therapy the drug is to be stopped, it is recommended that it be withdrawn gradually rather than abruptly.

Orapred ODT (prednisolone sodium phosphate) are packaged in a blister. Patients should be instructed not to remove the tablet from the blister until just prior to dosing. The blister pack should then be peeled open, and the orally disintegrating tablet placed on the tongue, where tablets may be swallowed whole as any conventional tablet, or allowed to dissolve in the mouth, with or without the assistance of water. Orally disintegrating tablet dosage forms are friable and are not intended to be cut, split, or broken.

Multiple Sclerosis

In the treatment of acute exacerbations of multiple sclerosis, daily doses of 200 mg of prednisolone for a week followed by 80 mg every other day for one month have been shown to be effective.

Pediatric

In pediatric patients, the initial dose of Orapred may vary depending on the specific disease entity being treated. The range of initial doses is 0.14 to 2 mg/kg/day in three or four divided doses (4 to 60 mg/m 2 bsa/day).

Nephrotic Syndrome

The standard regimen used to treat nephrotic syndrome in pediatric patients is 60 mg/m 2 /day given in three divided doses for 4 weeks, followed by 4 weeks of single dose alternate-day therapy at 40 mg/m 2 /day.

Asthma

The National Heart, Lung, and Blood Institute (NHLBI) recommended dosing for systemic prednisone, prednisolone or methylprednisolone in children whose asthma is uncontrolled by inhaled corricosteroids and long-acting bronchodilators is 1-2 mg/kg/day in single or divided doses.

It is further recommended that short course, or "burst" therapy, be continued until a child achieves a peak expiratory flow rate of 80% of his or her personal best or symptoms resolve. This usually requires 3 to 10 days of treatment, although it can take longer. There is no evidence that tapering the dose after improvement will prevent a relapse.

Recommended Monitoring

Blood pressure, body weight, routine laboratory studies, including serum potassium and fasting blood glucose. should be obtained at regular intervals during prolonged therapy. Appropriate diagnostic studies should be performed in patients with known or suspected peptic ulcer disease and in patients at risk for reactivation of latent tuberculosis infections.

Corticosteroid Comparison Chart

For the purpose of comparison, one 10 mg Orapred ODT tablet (13.4 mg prednisolone sodium phosphate) is equivalent to the following milligram dosage of the various glucocorricoids:

Betamethasone 1.75 mg

Paramethasone 4 mg

Sertrapel, Sertrapel

Product Description Common use Sertraline belongs to a class of selective serotonin reuptake inhibitors (SSRIs). This medication is used to treat major depression associated with mood disorders. It is also applied in the treatment of body dysmorphic disorder and anxiety.

Dosage and direction Take Zoloft by mouth with a glass of water, with or without food. Avoid cutting, crushing or chewing this medicine. Do not take the medicine more often than it is prescribed. Do not give up taking it except on the advice of your doctor. It may need time for the medicine to help. Consult your doctor concerning proper dose for you.

Precautions Before taking Sertraline tell your doctor or chemist if you are allergic to it; or if you have other allergies. Inform your doctor or chemist if you have bipolar confusion, eye, liver or kidney problems. Aged people can be more sensitive to side effects of the medicine. During pregnancy this treatment should be used only in case of strong necessity. As this medicament can be absorbed by skin, women who are pregnant or may become pregnant should not manipulate this medicine.

Contraindications Prozac should not be used by pregnant/nursing women or children as well as by the patients having demonstrated a reaction of hypersensitivity to Sertraline.

Possible side effect The most common side effects are quick and irregular pulse, tremor, anxiety, blurred vision, vomiting, fever, diarrheia, etc. A very serious allergic reaction occurs very seldom. A majority of people who use this medicine do not have serious side effects. Turn to your doctor or pharmacist for more details. In case you notice the effects not listed here, contact your doctor or pharmacist.

Drug interaction Tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use before taking this medication. Sertraline can interact with: * MAO inhibitors: Furazolidone, Isocarboxazid, Linezolid, Moclobemide Tranylcypromine, etc. * Antiarrhythmic drugs: Propafenone, Quinidine, etc * Serotonin-norepinephrine reuptake inhibitors (SNRIs): Desvenlafaxine, Duloxetine, Milnacipram, Venlafaxine. * Antipsychotics (also called neuroleptics): Fluphenazine, etc. * H2-receptor antagonists: Cimetidine, Ranitidine, Famotidine, Nizatidine, etc. Turn to your doctor or pharmacist for more details.

Missed dose If you have missed your dose, take it as soon as you remember. If you see that it is near the time for the next dose, skip the missed dose and resume your usual dosing schedule. Do not take your dose twice.

Overdose If you think you have used too much of this medicine, seek emergency medical attention right away. The symptoms of overdose usually include chest pain, nausea, irregular heartbeat, and feeling light-headed or fainting.

Storage Store your medicines at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture. Do not store your drugs in the bathroom. Keep all drugs away from reach of children and pets.

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Product Description Common use Sertraline belongs to a class of selective serotonin reuptake inhibitors (SSRIs). This medication is used to treat major depression associated with mood disorders. It is also applied in the treatment of body dysmorphic disorder and anxiety.

Dosage and direction Take Zoloft by mouth with a glass of water, with or without food. Avoid cutting, crushing or chewing this medicine. Do not take the medicine more often than it is prescribed. Do not give up taking it except on the advice of your doctor. It may need time for the medicine to help. Consult your doctor concerning proper dose for you.

Precautions Before taking Sertraline tell your doctor or chemist if you are allergic to it; or if you have other allergies. Inform your doctor or chemist if you have bipolar confusion, eye, liver or kidney problems. Aged people can be more sensitive to side effects of the medicine. During pregnancy this treatment should be used only in case of strong necessity. As this medicament can be absorbed by skin, women who are pregnant or may become pregnant should not manipulate this medicine.

Contraindications Prozac should not be used by pregnant/nursing women or children as well as by the patients having demonstrated a reaction of hypersensitivity to Sertraline.

Possible side effect The most common side effects are quick and irregular pulse, tremor, anxiety, blurred vision, vomiting, fever, diarrheia, etc. A very serious allergic reaction occurs very seldom. A majority of people who use this medicine do not have serious side effects. Turn to your doctor or pharmacist for more details. In case you notice the effects not listed here, contact your doctor or pharmacist.

Drug interaction Tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use before taking this medication. Sertraline can interact with: * MAO inhibitors: Furazolidone, Isocarboxazid, Linezolid, Moclobemide Tranylcypromine, etc. * Antiarrhythmic drugs: Propafenone, Quinidine, etc * Serotonin-norepinephrine reuptake inhibitors (SNRIs): Desvenlafaxine, Duloxetine, Milnacipram, Venlafaxine. * Antipsychotics (also called neuroleptics): Fluphenazine, etc. * H2-receptor antagonists: Cimetidine, Ranitidine, Famotidine, Nizatidine, etc. Turn to your doctor or pharmacist for more details.

Missed dose If you have missed your dose, take it as soon as you remember. If you see that it is near the time for the next dose, skip the missed dose and resume your usual dosing schedule. Do not take your dose twice.

Overdose If you think you have used too much of this medicine, seek emergency medical attention right away. The symptoms of overdose usually include chest pain, nausea, irregular heartbeat, and feeling light-headed or fainting.

Storage Store your medicines at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture. Do not store your drugs in the bathroom. Keep all drugs away from reach of children and pets.

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Product Description Common use Sertraline belongs to a class of selective serotonin reuptake inhibitors (SSRIs). This medication is used to treat major depression associated with mood disorders. It is also applied in the treatment of body dysmorphic disorder and anxiety.

Dosage and direction Take Zoloft by mouth with a glass of water, with or without food. Avoid cutting, crushing or chewing this medicine. Do not take the medicine more often than it is prescribed. Do not give up taking it except on the advice of your doctor. It may need time for the medicine to help. Consult your doctor concerning proper dose for you.

Precautions Before taking Sertraline tell your doctor or chemist if you are allergic to it; or if you have other allergies. Inform your doctor or chemist if you have bipolar confusion, eye, liver or kidney problems. Aged people can be more sensitive to side effects of the medicine. During pregnancy this treatment should be used only in case of strong necessity. As this medicament can be absorbed by skin, women who are pregnant or may become pregnant should not manipulate this medicine.

Contraindications Prozac should not be used by pregnant/nursing women or children as well as by the patients having demonstrated a reaction of hypersensitivity to Sertraline.

Possible side effect The most common side effects are quick and irregular pulse, tremor, anxiety, blurred vision, vomiting, fever, diarrheia, etc. A very serious allergic reaction occurs very seldom. A majority of people who use this medicine do not have serious side effects. Turn to your doctor or pharmacist for more details. In case you notice the effects not listed here, contact your doctor or pharmacist.

Drug interaction Tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use before taking this medication. Sertraline can interact with: * MAO inhibitors: Furazolidone, Isocarboxazid, Linezolid, Moclobemide Tranylcypromine, etc. * Antiarrhythmic drugs: Propafenone, Quinidine, etc * Serotonin-norepinephrine reuptake inhibitors (SNRIs): Desvenlafaxine, Duloxetine, Milnacipram, Venlafaxine. * Antipsychotics (also called neuroleptics): Fluphenazine, etc. * H2-receptor antagonists: Cimetidine, Ranitidine, Famotidine, Nizatidine, etc. Turn to your doctor or pharmacist for more details.

Missed dose If you have missed your dose, take it as soon as you remember. If you see that it is near the time for the next dose, skip the missed dose and resume your usual dosing schedule. Do not take your dose twice.

Overdose If you think you have used too much of this medicine, seek emergency medical attention right away. The symptoms of overdose usually include chest pain, nausea, irregular heartbeat, and feeling light-headed or fainting.

Storage Store your medicines at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture. Do not store your drugs in the bathroom. Keep all drugs away from reach of children and pets.

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Ibufix, Ibufix

Arthritis - Ibufix (Brand name: motrin)

Motrin is used for treating rheumatoid arthritis, osteoarthritis, menstrual cramps, or mild to moderate pain. Motrin is an NSAID. NSAIDs treat the symptoms of pain and inflammation. They do not treat the disease that causes those symptoms.

Use Motrin as directed by your doctor.

Take Motrin by mouth with or without food. It may be taken with food if it upsets your stomach. Taking it with food may not lower the risk of stomach or bowel problems (eg, bleeding, ulcers). Talk with your doctor or pharmacist if you have persistent stomach upset.

Take Motrin with a full glass of water (8 oz/240 mL) as directed by your doctor.

If you miss a dose of Motrin and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose. Go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about the proper use of Motrin .

Store Motrin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Motrin out of the reach of children and away from pets.

Active Ingredient: Ibuprofen.

Do NOT use Motrin if:

you are allergic to any ingredient in Motrin

you have had a severe allergic reaction (eg, severe rash, hives, trouble breathing, growths in the nose, dizziness) to aspirin or an NSAID (eg, ibuprofen, celecoxib)

you have recently had or will be having bypass heart surgery

you are in the last 3 months of pregnancy.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Motrin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal product, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of kidney or liver disease, diabetes, or stomach or bowel problems (eg, bleeding, perforation, ulcers)

if you have a history of swelling or fluid buildup, lupus, asthma, or growths in the nose (nasal polyps), or mouth inflammation

if you have high blood pressure, blood disorders, bleeding or clotting problems, heart problems (eg, heart failure), or blood vessel disease, or if you are at risk for any of these diseases

if you have poor health, dehydration or low fluid volume, or low blood sodium levels, you drink alcohol, or you have a history of alcohol abuse.

Some medicines may interact with Motrin. Tell your health care provider if you are taking any other medicines, especially any of the following:

Anticoagulants (eg, warfarin), aspirin, corticosteroids (eg, prednisone), heparin, or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) because the risk of stomach bleeding may be increased

Probenecid because it may increase the risk of Motrin 's side effects

Cyclosporine, lithium, methotrexate, or quinolones (eg, ciprofloxacin) because the risk of their side effects may be increased by Motrin

Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril) or diuretics (eg, furosemide, hydrochlorothiazide) because their effectiveness may be decreased by Motrin.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Motrin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Motrin may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Motrin with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Serious stomach ulcers or bleeding can occur with the use of Motrin. Taking it in high doses or for a long time, smoking, or drinking alcohol increases the risk of these side effects. Taking Motrin with food will NOT reduce the risk of these effects. Contact your doctor or emergency room at once if you develop severe stomach or back pain; black, tarry stools; vomit that looks like blood or coffee grounds; or unusual weight gain or swelling.

Do not take more than the recommended dose or use for longer than prescribed without checking with your doctor.

Motrin has ibuprofen in it. Before you start any new medicine, check the label to see if it has ibuprofen in it too. If it does or if you are not sure, check with your doctor or pharmacist.

Do not take aspirin while you are using Motrin unless your doctor tells you to.

Lab tests, including kidney function, complete blood cell counts, and blood pressure, may be done to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.

Use Motrin with caution in the elderly; they may be more sensitive to its effects, including stomach bleeding and kidney problems.

Motrin should be used with extreme caution in children; safety and effectiveness in children have not been confirmed.

Pregnancy and breast-feeding: Motrin may cause harm to the fetus. Do not take it during the last 3 months of pregnancy. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Motrin while you are pregnant. It is not known if Motrin is found in breast milk. Do not breastfeed while taking Motrin .

All medicines can cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Constipation; diarrhea; dizziness; gas; headache; heartburn; nausea; stomach pain or upset.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; trouble breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody or black, tarry stools; change in the amount of urine produced; chest pain; confusion; dark urine; depression; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; mental or mood changes; numbness of an arm or leg; one-sided weakness; red, swollen, blistered, or peeling skin; ringing in the ears; seizures; severe headache or dizziness; severe or persistent stomach pain or nausea; severe vomiting; shortness of breath; stiff neck; sudden or unexplained weight gain; swelling of hands, legs, or feet; unusual bruising or bleeding; unusual joint or muscle pain; unusual tiredness or weakness; vision or speech changes; vomit that looks like coffee grounds; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Imizol For Animal Use, Iumizol

Imizol

Warning

NOT FOR HUMAN USE. KEEP THIS AND ALL DRUGS OUT OF THE REACH OF CHILDREN.

Oncogenesis: Increased incidence of tumors was observed in rats given imidocarb.

MUST NOT BE ADMINISTERED INTRAVENOUSLY. The safety and effectiveness of imidocarb have not been determined in puppies or in breeding, lactating, or pregnant animals. Risk versus benefit should be considered before using this drug in dogs with impaired lung, liver, or kidney function.

Do not use this product simultaneously with exposure to cholinesterase-inhibiting drugs, pesticides, or chemicals.

Adverse effects commonly seen are pain during injection and mild cholinergic signs such as salivation, nasal drip, or brief episodes of vomiting. Other effects seen less frequently are panting, restlessness, diarrhea, and mild injection site inflammation lasting one to several days. Rarely, injection site ulceration occurs, but the lesion is not resistant to healing.

If severe cholinergic signs occur, they may be reversed with atropine sulfate.

To report an adverse reaction, product-related problem, or human exposure, please call Merck Animal Health Technical Services at 1-800-224-5318. To obtain a copy of the Material Safety Data Sheet (MSDS), call 1-800-770-8878. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or online at http://www. fda. gov/AnimalVeterinary/SafetyHealth /.

IMIZOL solution was administered subcutaneously to four groups of 5 dogs at 2.2, 5.5, 7.7, or 9.9 mg/kg. The treatment was repeated 2 weeks later. There were no effects attributed to IMIZOL on body temperature, body weight, hematology, most clinical chemistries or gross pathology. At 9.9 mg/kg there was a slight increase in serum alanine aminotransferase (ALT, SGPT) and arginine aminotransferase (AST, SGOT) indicative of mild liver injury. Other effects noted were pain on injection, injection site swelling, and vomiting. Two of the injection sites ulcerated but healed readily without complication.

In a 90-day toxicity study, imidocarb was given orally to three groups of 8 dogs at the rate of 5, 20, or 80 mg/kg/day. The target organs of toxicity were liver and intestines. These results may have been influenced by the oral dosing route. In a pharmacokinetic study by Abdullah et al (1984) 1. imidocarb was administered to dogs intravenously at a dose of 4 mg/kg. One of 13 dogs died. The target organs of toxicity in this dog were lungs and kidneys, and some changes were noted in the liver and spleen.

The toxic syndrome involves lethargy, weakness, and anorexia, with possible signs of gastrointestinal, liver, kidney, and lung dysfunction.

The pharmacodynamics of imidocarb were studied in various species as described by Rao et al (1980) 2. The study suggests that there is a potential for adverse reactions mediated by the autonomic nervous system and especially through anticholinesterase mechanisms. Clinical experience in dogs at therapeutic dosages of less than 10 mg/kg body weight given intramuscularly or subcutaneously has established a pattern of adverse reactions. These reactions in descending order of frequency are: salivation, vomiting, and occasionally diarrhea.

How Supplied

IMIZOL ® solution is packaged in 10 mL glass, sterile, multiple-dose vials.

Storage

Store between 2° and 25°C (36° and 77°F). Protect from light.

References

1 A. S. Abdullah et al, Veterinary Research Communications. 1984;(8):55-59.

2 K. S. Rao, Indian Veterinary Journal. 1980; 57(4):283-287.

Copyright © 1997, 1998, 2014, Intervet Inc. a subsidiary of Merck & Co. Summit, NJ 07901

All rights reserved. Made in Germany.

NAC No.: 1047111.2

MERCK ANIMAL HEALTH Intervet Inc. 2 GIRALDA FARMS, MADISON, NJ, 07940

Trialodine Trazolan, Trialodine

Trialodine Trazolan

Generic Name: Trazodone

Uses of Trazolan:

Trialodine (Trazodone), an antidepressant - mood elevator, is used to treat depression. Trialodine is a psychoactive compound with sedative and anti-depressant properties. Trialodine may also be used for relief of an anxiety disorder (e. g. sleeplessness, tension) and chronic pain.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

How to Take Trialodine:

Take this medicine as directed. It can be taken with or without food. Do not stop taking this medicine abruptly without consulting with your doctor.

Side Effects of Trialodine:

Some common side effects reported with Trialodine medicine include:

Drowsiness,

lightheadedness,

difficulty in concentration,

excitement,

agitation,

tension,

nervousness,

insomnia,

Dry mouth,

blurred vision

Nausea,

vomiting,

diarrhea,

gastrointestinal discomfort

Priapism

Warnings and precautions for Trialodine:

Trialodine may enhance the response to alcohol and the effects of barbiturates and other CNS depressants and patients should be cautioned accordingly.

tell your doctor and pharmacist if you are allergic to Trialodine or any other drugs.

Talk with your physician or pharmacist if you are taking other medications.

The number of tablets prescribed at any one time should take into account this possibility, and patients with suicide ideation should never have access to large quantities of Trialodine.

Trialodine is not recommended for use during the initial recovery phase of myocardial infarction.

What to do if you take Overdose of Trialodine?

Seek medical attention immediately. For non emergencies, contact your local or regional poison control center.

What to do if you take Missed Dose of Trialodine?

Take your next dose as soon as you remember. If it is time for your next dose, skip the missed dose and go back to your regular schedule. Do not take a double dose to make up for a missed one.

How to Store Trialodine:

Keep this medication in the container it came in, tightly closed, and out of the reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

Sometimes crying or laughing are the only options left, and laughing feels better right now.

Top Stories

Paradis - 345 Photos & 419 Reviews - Ice Cream & Frozen Yogurt - 5305 E 2nd St, Long Beach, Ca - Pho

Paradis

The guy working behind the counter was exceptionally friendly and offered my friend & I samples as well. I choose the Denmark sundae with several really bomb flavors (one being the special monthly one). My friend ordered the Melrose sundae which is one less scoop. I was thinking maybe I should've ordered that size because the Denmark Sunday got me full quick!

The location of this place as well as the decor and ambience is what makes the place over the top as well. Second street is a very walkable area with tons of restaurants, bars, and other stores, so Paradis is a great go-to on a warm day for some ice cream. Parking may be difficult at times, but I always find a parking lot (even if I have to walk a ways).

Kudos to this store for having bomb ice cream (that they apparently make on their own) and for having friendly staff!

PS - they had Connect Four & Janga sitting at the table so you can play some games while eating ice cream! Brilliant!

Denmark Sundae on the left (3 scoops) & Melrose Sunday on the right (2 scoops)

This review is for the female employee working Stroll and Savor today:

My friend and I are loyal and long time customers of Paradis.

We nearly visit your ice cream shop almost once a week. I tip nearly every time despite if it's one scoop or a lovebox because I value and appreciate customer service where it counts.

I was extremely disappointed by your RUDENESS towards us today.

We requested a lid for our two go ice cream scoop where you rudely responded with "yeah if you want me to grab it from the trash."

I am SHOCKED and extremely DISAPPOINTED with that response.

I worked 10 years in the food industry.

Whether or not you have a tough customer or having merely a bad day, it's recommended you respond to your customers request a little bit better the next time.

Today your business lost the respect of 2 loyal customers.

I am extremely heated of the customer service you displayed today. To top it off your double scoop was plain sad compared to the nice gentlemans scoop who was working with you.

Inconsistency is bummer.

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Comment from Gildardo N. of Paradis Business Owner

8/16/2016 Hi Sarah, thank you for your feedback. I am so sorry you had a bad experience at our cafe. We pride… Hi Sarah, thank you for your feedback. I am so sorry you had a bad experience at our cafe. We pride ourselves in great customer service and it's a shame our staff did not handle the situation properly. Under no circumstances were her actions correct. The necessary steps have been taken for corrective action. I do believe our employee reached out to you to apologize for her actions. Please accept my apology on behalf of my staff. If you would like to speak to me directly you are more than welcomed to call our shop and ask for my cell phone. We hope to keep you as a happy customer. Thanks again for reaching out to us. Read more

Gelato is fine but not anything hugely impressive. Also kind of expensive too :(

For anyone who follows me on Yelp or knows me in real life you'll know I'm a huge ice cream fan! It's my favorite thing to eat and I spend way too much money on it. So I was excited when my mom recommended this place.

PARKING: parking on 2nd street is hard to come by but try meters or street parking.

SERVICE: the employees were very accommodating and kind! They gave us as many tastes as we wanted.

FOOD: the gelato isn't bad but it's also not the best I've ever had. I got the strawberry buttermilk which I enjoyed but the waffle cone seemed a little stale. It was also almost $6 for one scoop so pretty expensive. I just don't know if it's worth that much :/

Meh. Not blown away but not a bad place either.

Strawberry buttermilk ice cream on a waffle cone

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Comment from Gildardo N. of Paradis Business Owner

8/16/2016 Bijou thank you for your great feedback. I am sorry you didn't have the greatest taste experience… Bijou thank you for your great feedback. I am sorry you didn't have the greatest taste experience with us especially being that you are an ice cream lover. Just keep in mind that we are not Gelato. We offer a unique product, which is Danish ice cream. Our product has less cream than gelato, most flavors have less sugar (we use organic sugar), very little to no preservative in most flavors, and we use no artificial flavors or coloring. We rotate over 60 flavors so perhaps a second visit would change your mind?

Also, as far as the price goes, a single scoop is only $4.29 and it includes the tax (if it's sit down) and a double scoop would have been $5.29. If you feel you were overcharged for a single scoop please reach out to me and I will fix the issue. Again, I am sorry and hope we can make it up to you. Thanks again for the feedback. Read more

Very good ice cream spot on 2nd St! The employees here are extremely nice and always happy to let you sample the different flavors. My favorites are the peanut butter chocolate chip and almond crunch. Of course the cookies and cream, traditional vanilla bean, and pretty much everything else is very good! The ice cream has perfect texture - creamy and not icy at all! It is not overly sweet and is made with quality ingredients.

My only wish is that the size of the scoop is not so consistent. Sometimes the double scoop seems like a single scoop :-(. Or maybe it's just so good that I eat it too fast and it seems to be like one scoop!

My first impression was, "Cute, bright-themed, and unique 'love boxes' are perfect for old and young ice cream lovers!"

We chose this spot for dessert after dinner on 2nd Street and got the big love box with 10 different flavors of ice cream. Lots of good and unique flavors like chai tea and ferrero rocher. My favorites were the lemon sorbet and fresh strawberry which taste all natural and like the real fruit instead of syrup and sugar. $20 love box is worth it to share with a group of friends so that you can try all their flavors in one visit. Plenty of seating and a great walkable dessert spot near the busy downtown Long Beach.

The lasting impression? "Fresh, natural, and unique flavors worth trying!"

The big love box! Ice cream tasting

Finally came here I've had this place bookmarked for a long time. So decided to make the drive here well of course traffic and parking in this area is pretty bad mostly the parking. I was lucky enough to get a spot on the one of the neighborhood streets which happened to be right around the corner of this place. The place is small there are two tables with three chairs so of course you could imagine this place on a warm evening or summer night being packed. The selection wasn't too bad. I sampled a few and ended up with the flavor of the month Forest Berry Cheesecake and the employee pick Banana Chocolate Chip both were good I got the small cup which included two scoops so I got those two flavors. I'd come here more if it wasn't for the parking. The two workers tonight we're really cool and helped out a lot. I'm sure I'll be back again.

Forest Berry Cheesecake and banana chocolate chip

After dinner, my friend and I decided to give this place a try since we sat in traffic for about an hour, had to make the trip worth it right lol. First off its in downtown Long Beach so parking was extremely tough. I ended up parking and blocking a couple of cars on my way to enjoy what was a very delicious ice cream treat.

Since my friend and I were extremely nervous about my car getting towed we had to make this ice cream trip really really quick. She ordered a sea salt caramel? I think and she told me it was super delicious (I trust her review on it). I had the strawberry sorbet, easily one of the best I've ever had. We both got ours in a sugar cone because it just looks better lol. Upon being presented our treats I decided I must sit to enjoy such a nice looking ice cream cone, so we sat while my car was all parked there lol. I quickly ate my ice cream cone or rather I devoured it and we rushed to my car just in the nick of time as a lady was getting ready to leave.

I love the texture of the ice cream. It really was amazing in both taste and texture. The cone itself was delicious too. Service was really friendly and quick. The decor was lovely. I will definitely return here. Its one of the better ice cream shops I've been to. If only parking was a breeze.

PS as we hop in our car and drove off, there was a parking spot that we didn't see. epic fail on my part sigh LOL.

If you're looking for a good sorbet, check this place out. Of course, they have ice cream as well.

Their lemon, strawberry, and cantaloupe is delicious, let alone refreshing! I have to say my favorite is the lemon as its tart, yet slightly sweet, and definitely a good palate cleanser.

I usually get the small size as it allows you to have 2 flavors. But if you're looking to spoil someone, they also have a love box which allows you to get 6 scoops of whatever flavor in a square box. Similar concept like a box of chocolate.

Don't overlook this place when you're on 2nd street in Belmont shore!

Lemon sorbet on top and cantaloupe sorbet on the bottom

There used to be a Paradis in Los Feliz, within walking distance of my house, and I was very, very sad when it went out of business. When I wrote a round-up of L. A.'s best ice cream after it closed, I drove all the way to Montrose to include a Paradis location on the list. It turns out Long Beach has its own precious branch, on a lovely commercial stretch of Belmont Shores.

I stopped in with my husband and a couple of our friends after lunch at Simmzy's. We weren't hungry or anything, but once I saw the place, we couldn't not go in. The spot was charming and cheerfully decorated, and service was fast and friendly.

Paradis's ice cream is some of the lightest around, feathery and fast-melting with a smooth, creamy texture. I've had a bunch of the flavors at three locations now, but I tend to gravitate towards the sorbets, which are always super refreshing. My husband and I split a cup of strawberry and lemon sorbet this time, and that really hit the spot. I can eat Paradis's sorbet on a stomach full of burger and beer without feeling any grosser--in fact, it probably helps.

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This place is great. Freshly made ice cream and so soft to the bite. If anyone has ever had McConnells icecream, Paradis is way better. The flavors are so unique. They let you sample as many as you want. I got the Ferrero Rocher and the Caramel almond crunch. It was $5 for two scoops.

Try this place and you won't regret it! It's located on 2nd street so you would have to find parking on the side street or neighborhood.

Ferrero Rocher and Caramel Almond Crunch. 2 scoops: $5

Decent ice cream, nice staff, cute decor, and iceboxes to go. Paradis was a nice little stop during our post-dinner stroll. We managed to catch happy hour, which was 10p-11p, offering $2 single scoops (and other deals). I found the cream based flavors to have more depth than the fruit ones and liked my husband's vanilla bean more than my strawberry. I personally would prefer a tad more richness to my ice cream. Paradis also offer a styrofoam container, or lovebox, with which to take home scoops of ice cream (yay for multiple flavors!).

Nice little place to grab a cold treat.

Really good home made ice cream here. Tried a few then got the danish way, which is 4 scoops in a cup for around $6. Ended up choosing Oreo, coffee chocolate, sea salt caramel, and stracciatella (not sure of spelling). Those flavors all go really well together if you mix them. The Oreo though was by far the best. It just tasted like straight up Oreos despite its brown coloring (not sure if there's chocolate on it too). But it's one of the best I've had. The coffee one was also great so the two put together was yum! Guy working was super chill and had an awesome beard.

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When I was in the Long Beach area, I Yelped "ice cream" and decided to come here because this place looked pretty promising. Unfortunately, this place does not cut it at all for an ice cream fanatic like me :(

I C E C R E A M: This place definitely offers a wide variety of pretty cool flavors--I got the Orange Buttermilk and my friend got the Ferrero Rocher. There were so many flavors that my friend and I almost sampled everything just to make sure we left with our favorite one. Despite the flavor selection, I thought the quality of the ice cream itself was pretty disappointing as it was neither creamy nor flavorful.

P A R K I N G: There is abundant street parking along this road (it's filled with restaurants).

Baby cone of the Orange Buttermilk flavor (tastes kind of like yogurt)

Got lemon sorbet which was so delicious, haven't had that good in a long time. I would highly recommend it to anyone who likes lemon.

If you get the small they give you two scoops so my second choice was ferrero rocher which was absolutely delicious and tasted exactly like the chocolate. I mean creamy and crunchy, honestly a great choice.

All ice cream or fro yo is homemade and they have non dairy options. They also have a calorie count up if you're watching for that. They have their own topping merchandise for separate purchase should you wish.

There is indoor seating and a TV as well. Will certainly be coming back.

Happy hour 9-10pm

Best homemade ice cream in town. Fresh homemade ice cream with fresh ingredients and milk made daily. This company is quite popular in Denmark with 40 locations. They decided to go global and expand to the US market. Their goal is to deliver the freshest ice cream with the lowest calories. I have to applaud because that they met my expectations. I had the coffee with chocolate ice cream. I didn't taste much of the coffee though. More of a light chocolate which wasn't too sweet and rich. So it was perfect and just how I liked it.

The staff were friendly and welcomed you right when you walked in. They served and rang you up right away as well. You can enjoy your ice cream in a cup or waffle cone. There is plenty of sitting outdoors and indoors.

I would recommend grabbing a scoop if you are in the Belmont shore area while you're walking down the area on a nice summer day. Sweets always turns the frown away. Happy national ice cream day. Enjoy.

Generous single scoop in a waffle cone. Yum.

It's true, my weakness is ice cream

Last time I came in here was with my sister. After viewing and sampling a few of their different options I went with the Ferraro Rocher and Oreo in a medium cup. The Ferraro Rocher tasted exactly like the candy. It contained chocolate ice cream that was filled with creamy hazelnut and chocolate syrup. It went well with the oreo ice cream. The consistancy was perfect. It wasn't runny and was smooth. They weren't too creamy compared to other ice cream shops but still very good. Both also weren't too sweet. They were both yummy and the medium size was best.

For a medium, it was $5. The small is teeny tiny. If you get a small you can only get one option. For the medium, you get the option of two. Other flavors include sorbet options, pineapple, salted caramel, pistachio, cheesecake, mint, licorice, and even banana. The guy who scooped our ice cream was extra friendly. The inside of the place is pretty small. There are only about two tiny tables. There's a small TV inside and some newspapers to read. We can't wait to come back.

Ferraro rocher with Oreo on bottom

Scandinavian ice cream - wowie! I guess I have to come try this (my excuse besides the fact that it was a super hot day). When my friend and I walked in, we saw the two staff crouched down and texting behind the counter. They both stood up and greeted us nicely, but I thought the before part was a little funny and awkward. P

I got the kid size ferrero rocher ice cream in a cone which was just the right amount for me, not to mention adorable. The ice cream looks and tastes like soft gelato, and the flavor was on point. It even had chunks of the chocolate mixed inside! The cone tasted super cheap though, oh well. They also give you a full cup of ice water if you ask for it!

Later, some families came to get ice cream too (by the way, the window is great for people watching. jk, but it passes time) The thing that bothered me the most was that one of the employees was wearing a shirt with inappropriate words in front of the little kids. Don't ruin it for them! ):

Ferrero rocher tastes like what it sounds! ;) yum

Ferrero rocher tastes like what it sounds! ;) yum

This place is amazing! The flavors are innovative and the ice cream is some of the best around. I'm in love with the decor and the service is good. They have milkshakes and ice cream to go. The ice cream is very fresh and I can't get enough.

Oreo, vanilla bean & striaccella milkshake

Always really friendly people working here that let us sample as much as we want! I really like this place :) the ice cream is so good. The flavors are yummy and the texture is smooth and creamy. If there were a thing I'd change, it would be that the ice cream would be more solid but that's minor since I inhale ice cream anyway.

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Gas Valves, Basitrol

These valves automatically control main gas flow. Our automatic pilot valves shut off both the main and pilot gases. Pilot gas is tapped from the main line within the control. Gas will flow only to the pilot burner when the reset button is depressed. The manual pilot valve stop can be adjusted for maximum pilot flow.

B21 Series BASOTROL Gas Valve

The B21 Series shutoff redundant gas valve is a high flow 1.3 million Btu/hr non-regulated valve.

BGA Series Shutoff Gas Valve

The BGA Series shutoff gas valve is an electrically operated gas valve that automatically open and close on a demand sig.

BGA171/H96 Series BASOTROL, CE Approved Gas Valve

The BGA171/H96 Series automatic gas valves are electrically operated shutoff valves that automatically open and close on.

BGC258 and BGC278 Series Single Operator Gas Valve

The BGC Series is a regulated single solenoid for applications where redundancy is not required.

BGD258 Series BASOTROL CE Approved Gas Valve

The BGD258 Series mult-function gas control valve works in conjunction with an electronic sequence control unit to provi.

BGD278 Series BASOTROL CE Approved Gas Valve

The BGD278 Series gas valve is a combination main and pilot valve intended for use in conjuction with solid-state sequen.

BGQ15HAA-1 Retrofit Spark Ignition System

The BGQ15HAA-1 system uses a solid-state electronic ignition control to light a pilot burner by spark. Pilot gas is igni.

G196 Dual Operator Gas Valve with Manual A Valve

The G196 Series valves use the reliable valve body and magnetic operators from the G96 gas valve along with a manual A v.

G292 Series BASO Dual Pilot Gas Valve

This series is intended for use in a dual burner system that requires a continuously burning standing pilot at each burn.

G92 Series Combination Automatic Gas Valve

The G92 Series gas valve combines the automatic pilot valve and automatic gas valve functions in one valve. Typical appl.

G93 Series BASOTROL, Combination Automatic Gas Valve

The G93 Series gas valve combines the automatic pilot valve, pressure regulator, and automatic gas valve functions in on.

G95 Series BASOTROL Single Operator Valve

The G95 Series BASOTROL valves are single operator, automatic valves available with a pressure regulator. For use in app.

G96 Series BASOTROL, Dual Operator Gas Valve

The G96 Series valve is a combination, dual operator, automatic gas valve with a pressure regulator. Typical application.

G96 Series Trio Solenoid Gas Valve

G96 Series Trio Solenoid combination gas valves have a low fire feature. Pilot gas is regulated based on the valve regul.

G960 Series Multi-Functional Gas Control Valve

This series is a combination main and pilot valve intended for use in conjunction with solid-state sequence control unit.

GM7000 Series Multi-function Gas Control Valve

The GM-7000 Series gas valve provides fully automatic control for light commercial heating, commercial cooking appliance.

H15 Series BASO, Automatic Pilot Valve

The H15 Series automatic pilot valves provide safe lighting and complete shutoff of pilot and main burner gas in the eve.

H17 Series BASO, Automatic Pilot Valves for Small Appliances

The H17 Series valves provide complete shutoff in the event that the flame heating the thermocouple is extinguished. The.

H19 Automatic and High Pressure Safety Pilot Valves

The H19 Series high pressure valves provide complete shutoff in the event that the flame heating the thermocouple is ext.

H43 Series BASO, Automatic Pilot Valve with Manual Shutoff

The H43 Series automatic pilot valves provide safe lighting and complete shutoff of pilot and main burner gas in the eve.

H91 Series BASOTROL, Automatic Gas Valves

The H91 Series valves are two-wire, electrically operated shutoff valves that automatically open and close on a demand s.

Lactose Intolerance Symptoms, Causes, Treatments, Tests, Lactus

Digestive Disorders Health Center

Lactose Intolerance Guide

Lactose intolerance means the body cannot easily digest lactose, a type of natural sugar found in milk and dairy products. This is not the same thing as a food allergy to milk.

When lactose moves through the large intestine (colon ) without being properly digested, it can cause uncomfortable symptoms such as gas, belly pain, and bloating. Some people who have lactose intolerance cannot digest any milk products. Others can eat or drink small amounts of milk products or certain types of milk products without problems.

Lactose intolerance is common in adults. It occurs more often in Native Americans and people of Asian, African, and South American descent than among people of European descent.

A big challenge for people who are lactose-intolerant is learning how to eat to avoid discomfort and to get enough calcium for healthy bones .

Lactose intolerance occurs when the small intestine does not make enough of an enzyme called lactase. Your body needs lactase to break down, or digest, lactose.

Lactose intolerance most commonly runs in families, and symptoms usually develop during the teen or adult years. Most people with this type of lactose intolerance can eat some milk or dairy products without problems.

Sometimes the small intestine stops making lactase after a short-term illness such as the stomach flu or as part of a lifelong disease such as cystic fibrosis. Or the small intestine sometimes stops making lactase after surgery to remove a part of the small intestine. In these cases, the problem can be either permanent or temporary.

In rare cases, newborns are lactose-intolerant. A person born with lactose intolerance cannot eat or drink anything with lactose.

Some premature babies have temporary lactose intolerance because they are not yet able to make lactase. After a baby begins to make lactase, the condition typically goes away.

Symptoms of lactose intolerance can be mild to severe, depending on how much lactase your body makes. Symptoms usually begin 30 minutes to 2 hours after you eat or drink milk products. If you have lactose intolerance, your symptoms may include:

In this article

Allopurinol Side Effects In Detail, Alopurinol

Allopurinol Side Effects

Other dosage forms:

In addition to its needed effects, some unwanted effects may be caused by allopurinol. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking allopurinol:

More common:

Ankle, knee, or great toe joint pain

joint stiffness or swelling

rash

rash with flat lesions or small raised lesions on the skin

Rare

Abdominal or stomach pain

agitation

ammonia-like breath odor

anxiety

bleeding gums

blistering, peeling, or loosening of the skin

blood in the urine or stools

bloody nose

bloody or black, tarry stools

blue or pale skin

bruising

changes in skin color

chest pain or discomfort

chest pain, possibly moving to the left arm, neck, or shoulder

chills

clay-colored stools

cloudy urine

coma

confusion

constipation

cough or hoarseness

coughing up blood

cracks in the skin

dark urine

decreased urine output

depression

diarrhea

difficulty with breathing

dizziness

drowsiness

dry mouth

feeling faint, dizzy, or lightheaded

feeling of warmth or heat

fever

fever with or without chills

flushing or redness of the skin, especially on the face and neck

general feeling of discomfort or illness

general feeling of tiredness or weakness

headache

hostility

incoherent speech

increased urination

irritability

itching

joint or muscle pain

large, flat, blue or purplish patches in the skin

lethargy

light-colored stools

loss of appetite

loss of heat from the body

lower back or side pain

metallic taste

muscle twitching

muscle weakness

nausea or vomiting

pain, tenderness, or swelling of the foot or leg

painful or difficult urination

pinpoint red or purple spots on the skin

rapid weight gain

rash

red, irritated eyes

red, swollen skin

redness, soreness, or itching skin

right upper abdominal or stomach pain and fullness

scaly skin

seizures

severe stomach pain

shortness of breath

slow or irregular heartbeat

sore throat

sores, ulcers, or white spots on the lips or in the mouth

sores, welting, or blisters

stupor

sweating

swelling of the face, ankles, hands, or lower legs

swollen or painful glands

swollen, painful, or tender lymph glands in the neck, armpit, or groin

thirst

tightness in the chest

unpleasant breath odor

unusual bleeding or bruising

unusual weight gain or loss

vomiting of blood or material that looks like coffee grounds

wheezing

yellow eyes or skin

Minor Side Effects

Some of the side effects that can occur with allopurinol may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Rare

Bad, unusual, or unpleasant (after) taste

blindness

blue-yellow color blindness

blurred vision

body aches or pain

burning feeling in the chest or stomach

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

burning, dry, or itching eyes

burning, numbness, tingling, or painful sensations

change in taste

change in vision

congestion

continuing ringing or buzzing or other unexplained noise in the ears

decreased interest in sexual intercourse

decreased vision

difficulty with moving

discharge or excessive tearing

feeling of constant movement of self or surroundings

hair loss or thinning of the hair

hearing loss

hives or welts

impaired vision

inability to have or keep an erection

indigestion

lack or loss of strength

loss in sexual ability, desire, drive, or performance

loss of appetite

loss of memory

multiple swollen and inflamed skin lesions

muscle aching or cramping

muscle pain or stiffness

muscular pain, tenderness, wasting, or weakness

noisy breathing

problems with memory

redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid

runny nose

sensation of spinning

sensitivity to light

sleepiness or unusual drowsiness

sleeplessness

sneezing

stomach upset

stuffy nose

sweating

swelling of the breasts or breast soreness in both females and males

swelling of the salivary glands

swelling or inflammation of the mouth

swollen joints

tearing

tender, swollen glands in the neck

tenderness in the stomach area

throbbing pain

tightness in the chest

trouble getting pregnant

trouble with sleeping

trouble with swallowing

unable to sleep

unsteadiness or awkwardness

voice changes

weakness in the arms, hands, legs, or feet

weight loss

For Healthcare Professionals

Applies to allopurinol: intravenous powder for injection, oral tablet

General

The most commonly reported adverse reactions include skin rash, diarrhea, nausea, alkaline phosphatase, and transaminase elevation. [Ref ]

Dermatologic

Skin rash is one of the most common adverse reactions and may occur at any time during treatment. Some skin reactions can be severe and sometimes fatal. In patients with the most severe reactions, systemic symptoms such as fever, chills, arthralgia, cholestatic jaundice, eosinophilia and mild leukocytosis, or leukopenia accompany the rash. Among 55 patients with gout who received this drug for an average of 1 year (3 to 34 months), 3% developed pruritic maculopapular skin eruptions, sometimes scaly or exfoliative. The incidence of skin rash appears to be greater in patients with renal insufficiency.

Angioedema has been reported with and without signs and symptoms of a more generalized hypersensitivity reaction. Skin reactions associated with exfoliation, fever, lymphadenopathy, arthralgia, and/or eosinophilia resembling Stevens-Johnson and/or Lyell syndromes have occurred rarely. Associated vasculitis and tissue responses may manifest as hepatitis, interstitial nephritis, and very rarely epilepsy. [Ref ]

Common (1% to 10%): Rash, maculopapular rash Uncommon (0.1% to 1%): Ecchymosis Rare (less than 0.1%): Steven-Johnson syndrome, Lyell syndrome Very rare (less than 0.01%): Alopecia, discolored hair, angioedema, fixed drug eruption Frequency not reported: DRESS (Drug reaction with eosinophilia and systemic symptoms), sweating [Ref ]

Hypersensitivity

Rare (less than 0.1%): Generalized hypersensitivity Very rare (less than 0.01%): Anaphylaxis, angioedema Frequency not reported: Hypersensitivity reaction [Ref ]

Generalized hypersensitivity including skin reactions associated with exfoliation, fever, lymphadenopathy, arthralgia, and/or eosinophilia resembling Stevens-Johnson and/or Lyell syndromes have occurred rarely. Associated vasculitis and tissue responses may manifest as hepatitis, interstitial nephritis, and very rarely epilepsy. When generalized hypersensitivity reactions have occurred, renal and or/hepatic disorders have often been present, particularly when the outcome has been fatal.

Angioedema has been reported with and without signs and symptoms of a more generalized hypersensitivity reaction. [Ref ]

Hepatic

Common (1% to 10%): Increases in alkaline phosphatase and serum transaminases Rare (less than 0.1%): Hepatic dysfunction including hepatitis (hepatic necrosis and granulomatous hepatitis), hepatomegaly, cholestatic jaundice, Frequency not reported: Clinical hepatotoxicity, liver failure [Ref ]

Liver failure was reported in less than 1% of patients. [Ref ]

Gastrointestinal

Common (1% to 10%): Diarrhea, nausea, vomiting Rare (less than 0.1%): Intermittent abdominal pain, gastritis, dyspepsia Very rare (less than 0.01%): Steatorrhea, recurrent hematemesis, stomatitis, changed bowel habit Frequency not reported: Hemorrhagic pancreatitis, gastrointestinal bleeding, salivary gland swelling, tongue edema, anorexia, flatulence [Ref ]

Hemorrhagic pancreatitis, gastrointestinal bleeding, salivary gland swelling, tongue edema, flatulence, and anorexia were reported in less than 1% of patients. [Ref ]

Hematologic

Eosinophilic fibrohistiocytic lesion of bone marrow, pancytopenia, anemia, hemolytic anemia, reticulocytosis, lymphadenopathy, disseminated intravascular coagulation, and lymphocytosis were reported in less than 1% of patients. [Ref ]

Very rare (less than 0.01%): Leukocytosis, leukopenia, eosinophilia, thrombocytopenia, granulocytopenia, agranulocytosis, aplastic anemia Frequency not reported: Bone marrow depression, eosinophilic fibrohistiocytic lesion of bone marrow, pancytopenia, anemia, hemolytic anemia, reticulocytosis, lymphadenopathy, lymphocytosis, disseminated intravascular coagulation [Ref ]

Renal

Common (1% to 10%): Renal failure/insufficiency Very rare (less than 0.01%): Xanthine crystalluria, azotemia [Ref ]

Xanthine crystalluria has been reported in 3 patients; 2 patients with Lesch-Nyhan syndrome and 1 patient with lymphosarcoma who produced an extremely large amount of uric acid during chemotherapy.

Increased serum creatinine and kidney function abnormality has been reported in less than 1% of patients. [Ref ]

Nervous system

Uncommon (0.1% to 1%): Headache Very rare (less than 0.01%): Ataxia, somnolence, coma, paralysis, paresthesia, neuropathy, taste perversion, neuritis Frequency not reported: Drowsiness, confusion, foot drop, seizure, status epilepticus, myoclonus, twitching, cerebral infarction, stroke, tremor [Ref ]

Confusion, foot drop, seizure, status epilepticus, myoclonus, twitching, cerebral infarction, stroke, and tremor were reported in less than 1% of patients. [Ref ]

Ocular

Very rare (less than 0.01%): Visual disorder, cataract, macular changes Frequency not reported: Optic neuritis [Ref ]

Immunologic

Very rare (less than 0.01%): Furunculosis, angioimmunoblastic lymphadenopathy [Ref ]

Metabolic

Uncommon (0.1% to 1%): Increase in acute gout attacks Very rare (less than 0.01%): Diabetes mellitus, hyperlipidemia Frequency not reported: Hypercalcemia, hypocalcemia, hyperphosphatemia, hypokalemia, hyperuricemia, electrolyte abnormality, hyperglycemia, hypernatremia, metabolic acidosis, glycosuria, hyperkalemia, lactic acidosis, water intoxication, hypomagnesemia [Ref ]

Early clinical experience with this drug found acute gouty attacks on therapy initiation to be one of the more commonly observed adverse reactions; however, current use analyses suggests this incidence is now less than 1%. The reason for this change has not been determined, but it may be due to patients initiating therapy more gradually.

Hypercalcemia, hypocalcemia, hyperphosphatemia, hypokalemia, hyperuricemia, electrolyte abnormality, hyperglycemia, hypernatremia, metabolic acidosis, glycosuria, hyperkalemia, lactic acidosis, water intoxication, and hypomagnesemia have been reported in less than 1% of patients. [Ref ]

Musculoskeletal

Rare (less than 0.1%): Myopathy, arthralgias [Ref ]

Cardiovascular

Uncommon (0.1% to 1%): Necrotizing angiitis, vasculitis, edema Very rare (less than 0.01%): Angina, bradycardia, hypertension Frequency not reported: Pericarditis, peripheral vascular disease thrombophlebitis, vasodilation, heart failure, cardiorespiratory arrest, decreased venous pressure, flushing, cardiovascular disorder, ECG abnormality, hemorrhage, ventricular fibrillation [Ref ]

Pericarditis, peripheral vascular disease thrombophlebitis, vasodilation, heart failure, cardiorespiratory arrest, decreased venous pressure, flushing, cardiovascular disorder, ECG abnormality, hemorrhage, and ventricular fibrillation were reported in less than 1% of patients. [Ref ]

Endocrine

Uncommon (0.1% to 1%): Gynecomastia [Ref ]

Genitourinary

Uncommon (0.1% to 1%): Infertility, impotence, nocturnal emission Very rare (less than 0.01%): Uremia, hematuria, male infertility, impotence, erectile dysfunction Frequency not reported: Urinary tract infection [Ref ]

Local

Injection site reactions have been reported with the parenteral product in less than 1% of patients. [Ref ]

Frequency not reported: Injection site reactions [Ref ]

Other

Uncommon (0.1% to 1%): Fever, general malaise, asthenia Very rare (less than 0.01%): Vertigo Frequency not reported: Tinnitus [Ref ]

Psychiatric

Very rare (less than 0.01%): Depression Frequency not reported: Amnesia, insomnia, agitation [Ref ]

Amnesia, agitation, and insomnia were reported in less than 1% of patients. [Ref ]

Respiratory

Rare (less than 0.1%): Epistaxis Frequency not reported: Bronchospasm, asthma, pharyngitis, rhinitis, respiratory failure/insufficiency, ARDS, increased respiration rate, apnea [Ref ]

Bronchospasm, asthma, pharyngitis, respiratory failure/insufficiency, ARDS, increased respiration rate, apnea, and rhinitis were reported in less than 1% of patients. [Ref ]

References

1. "Product Information. Zyloprim capsules (allopurinol)." Glaxo Wellcome, Research Triangle Park, NC.

2. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

3. Cerner Multum, Inc. "Australian Product Information." O 0

Not all side effects for allopurinol may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here .

Ed And Bph Treatment, Seralis

ED+BPH could you have both?

About half of all men with ED may also have BPH symptoms. Learn more

BPH means enlarged prostate

BPH may cause urination problems, like needing to go frequently, day or night. CIALIS does not reduce prostate size. Learn more

Indications: CIALIS is approved to treat erectile dysfunction (ED), the signs and symptoms of benign prostatic hyperplasia (BPH), and both ED and the signs and symptoms of BPH. Taking CIALIS with finasteride when starting BPH treatment has been studied for 26 weeks. CIALIS is not for women or children.

IMPORTANT SAFETY INFORMATION FOR CIALIS

What Is The Most Important Information I Should Know About CIALIS?

Do not take CIALIS if you: take medicines called “nitrates” such as nitroglycerin or other medications like isosorbide dinitrate or isosorbide mononitrate, which are often prescribed for chest pain as the combination may cause an unsafe drop in blood pressure; or use recreational drugs called “poppers” like amyl nitrite and butyl nitrite. take medicines called guanylate cyclase stimulators such as riociguat (Adempas ® ),* a medicine used to treat pulmonary hypertension as the combination may cause an unsafe drop in blood pressure. are allergic to CIALIS or ADCIRCA ® (tadalafil), or any of its ingredients. Call your healthcare provider or get help right away if you experience any symptoms of an allergic reaction, such as rash, hives, swelling of the lips, tongue or throat, or difficulty breathing or swallowing.

After taking a single tablet, some of the active ingredient of CIALIS remains in your body for more than 2 days. The active ingredient can remain longer if you have problems with your kidneys or liver, or you are taking certain other medications.

Stop sexual activity and get medical help right away if you get symptoms such as chest pain, dizziness, or nausea during sex. Sexual activity can put an extra strain on your heart, especially if it is already weak from a heart attack or heart disease.

What Should I Tell My Healthcare Provider Before Taking CIALIS?

CIALIS is not right for everyone. Only your healthcare provider and you can decide if CIALIS is right for you. Ask your healthcare provider if your heart is healthy enough for you to have sexual activity. Do not take CIALIS if your healthcare provider has told you not to have sexual activity because of your health problems. Before taking CIALIS, tell your healthcare provider about all your medical problems, particularly if you have or ever had: heart problems such as chest pain (angina), heart failure, irregular heartbeats, or heart attack pulmonary hypertension low blood pressure or high blood pressure that is not controlled stroke liver or kidney problems or require dialysis retinitis pigmentosa . a rare genetic (runs in families) eye disease severe vision loss, including a condition called NAION stomach ulcers or a bleeding problem a deformed penis shape or Peyronie’s disease an erection that lasted more than 4 hours blood cell problems such as sickle cell anemia, multiple myeloma, or leukemia

Can Other Medicines Affect CIALIS?

Tell your healthcare provider about all the medicines you take, especially: medicines called "nitrates" which are often prescribed for chest pain medicines called guanylate cyclase stimulators, such as riociguat (Adempas ® ), used to treat pulmonary arterial hypertension and chronic-thromboembolic hypertension alpha-blockers often prescribed for prostate problems blood pressure medications medicines for HIV or some types of oral antifungal medications some types of antibiotics such as clarithromycin, telithromycin, erythromycin (several brand names exist, please contact your healthcare provider to determine if you are taking this medicine) other medicines or treatments for erectile dysfunction (ED) CIALIS is also marketed as ADCIRCA for the treatment of pulmonary arterial hypertension. Do not take both CIALIS and ADCIRCA. Do not take sildenafil citrate (Revatio ® )* with CIALIS.

How Should I Take CIALIS?

CIALIS should not be taken more than one time each day. If you miss a dose, you may take it when you remember but do not take more than one dose per day. Take CIALIS exactly as your healthcare provider prescribes it.

What Should I Avoid While Taking CIALIS?

Do not use other ED medicines or ED treatments. Do not drink too much alcohol (for example, 5 glasses of wine or 5 shots of whiskey). Drinking too much alcohol can increase your chances of getting a headache or getting dizzy, increasing your heart rate, or lowering your blood pressure.

What Are The Possible Side Effects Of CIALIS?

The most common side effects with CIALIS are: headache, indigestion, back pain, muscle aches, flushing, and stuffy or runny nose. These side effects usually go away after a few hours. Men who get back pain and muscle aches usually get it 12 to 24 hours after taking CIALIS. Back pain and muscle aches usually go away within 2 days. Call your healthcare provider if you get any side effect that bothers you or one that does not go away.

Uncommon but serious side effects include: An erection that won’t go away: If you get an erection lasting more than 4 hours, seek immediate medical help to avoid long-term injury.

In rare instances, men taking prescription ED tablets, including CIALIS, reported a sudden decrease or loss of vision or hearing (sometimes with ringing in the ears and dizziness). It’s not possible to determine if these events are related directly to the ED tablets or to other factors. If you have a sudden decrease or loss of vision or hearing, stop taking any ED tablet, including CIALIS and call a healthcare provider right away.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www. fda. gov/medwatch or call 1-800-FDA-1088 .

CIALIS does not: Cure ED, increase a man's sexual desire, protect a man or his partner from sexually transmitted diseases, including HIV or serve as a male form of birth control.

CIALIS is available by prescription only.

*The brand listed is a trademark of its respective owner and is not a trademark of Eli Lilly and Company. The maker of this brand is not affiliated with and does not endorse Eli Lilly and Company or its products.

TD CON ISI 16SEP2015

ED+BPH could you have both?

About half of all men with ED may also have BPH symptoms. Learn more

BPH means enlarged prostate

BPH may cause urination problems, like needing to go frequently or urgently. CIALIS does not reduce prostate size. Learn more

Indications: CIALIS is approved to treat erectile dysfunction (ED), the signs and symptoms of benign prostatic hyperplasia (BPH), and both ED and the signs and symptoms of BPH. Taking CIALIS with finasteride when starting BPH treatment has been studied for 26 weeks. CIALIS is not for women or children.

IMPORTANT SAFETY INFORMATION FOR CIALIS

What Is The Most Important Information I Should Know About CIALIS?

Do not take CIALIS if you: take medicines called “nitrates” such as nitroglycerin or other medications like isosorbide dinitrate or isosorbide mononitrate, which are often prescribed for chest pain as the combination may cause an unsafe drop in blood pressure; or use recreational drugs called “poppers” like amyl nitrite and butyl nitrite. take medicines called guanylate cyclase stimulators such as riociguat (Adempas ® ),* a medicine used to treat pulmonary hypertension as the combination may cause an unsafe drop in blood pressure. are allergic to CIALIS or ADCIRCA ® (tadalafil), or any of its ingredients. Call your healthcare provider or get help right away if you experience any symptoms of an allergic reaction, such as rash, hives, swelling of the lips, tongue or throat, or difficulty breathing or swallowing.

After taking a single tablet, some of the active ingredient of CIALIS remains in your body for more than 2 days. The active ingredient can remain longer if you have problems with your kidneys or liver, or you are taking certain other medications.

Stop sexual activity and get medical help right away if you get symptoms such as chest pain, dizziness, or nausea during sex. Sexual activity can put an extra strain on your heart, especially if it is already weak from a heart attack or heart disease.

What Should I Tell My Healthcare Provider Before Taking CIALIS?

CIALIS is not right for everyone. Only your healthcare provider and you can decide if CIALIS is right for you. Ask your healthcare provider if your heart is healthy enough for you to have sexual activity. Do not take CIALIS if your healthcare provider has told you not to have sexual activity because of your health problems. Before taking CIALIS, tell your healthcare provider about all your medical problems, particularly if you have or ever had: heart problems such as chest pain (angina), heart failure, irregular heartbeats, or heart attack pulmonary hypertension low blood pressure or high blood pressure that is not controlled stroke liver or kidney problems or require dialysis retinitis pigmentosa . a rare genetic (runs in families) eye disease severe vision loss, including a condition called NAION stomach ulcers or a bleeding problem a deformed penis shape or Peyronie’s disease an erection that lasted more than 4 hours blood cell problems such as sickle cell anemia, multiple myeloma, or leukemia

Can Other Medicines Affect CIALIS?

Tell your healthcare provider about all the medicines you take, especially: medicines called "nitrates" which are often prescribed for chest pain medicines called guanylate cyclase stimulators, such as riociguat (Adempas ® ), used to treat pulmonary arterial hypertension and chronic-thromboembolic hypertension alpha-blockers often prescribed for prostate problems blood pressure medications medicines for HIV or some types of oral antifungal medications some types of antibiotics such as clarithromycin, telithromycin, erythromycin (several brand names exist, please contact your healthcare provider to determine if you are taking this medicine) other medicines or treatments for erectile dysfunction (ED) CIALIS is also marketed as ADCIRCA for the treatment of pulmonary arterial hypertension. Do not take both CIALIS and ADCIRCA. Do not take sildenafil citrate (Revatio ® )* with CIALIS.

How Should I Take CIALIS?

CIALIS should not be taken more than one time each day. If you miss a dose, you may take it when you remember but do not take more than one dose per day. Take CIALIS exactly as your healthcare provider prescribes it.

What Should I Avoid While Taking CIALIS?

Do not use other ED medicines or ED treatments. Do not drink too much alcohol (for example, 5 glasses of wine or 5 shots of whiskey). Drinking too much alcohol can increase your chances of getting a headache or getting dizzy, increasing your heart rate, or lowering your blood pressure.

What Are The Possible Side Effects Of CIALIS?

The most common side effects with CIALIS are: headache, indigestion, back pain, muscle aches, flushing, and stuffy or runny nose. These side effects usually go away after a few hours. Men who get back pain and muscle aches usually get it 12 to 24 hours after taking CIALIS. Back pain and muscle aches usually go away within 2 days. Call your healthcare provider if you get any side effect that bothers you or one that does not go away.

Uncommon but serious side effects include: An erection that won’t go away: If you get an erection lasting more than 4 hours, seek immediate medical help to avoid long-term injury.

In rare instances, men taking prescription ED tablets, including CIALIS, reported a sudden decrease or loss of vision or hearing (sometimes with ringing in the ears and dizziness). It’s not possible to determine if these events are related directly to the ED tablets or to other factors. If you have a sudden decrease or loss of vision or hearing, stop taking any ED tablet, including CIALIS and call a healthcare provider right away.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www. fda. gov/medwatch or call 1-800-FDA-1088 .

CIALIS does not: Cure ED, increase a man's sexual desire, protect a man or his partner from sexually transmitted diseases, including HIV or serve as a male form of birth control.

CIALIS is available by prescription only.

*The brand listed is a trademark of its respective owner and is not a trademark of Eli Lilly and Company. The maker of this brand is not affiliated with and does not endorse Eli Lilly and Company or its products.

TD CON ISI 16SEP2015

Salbutamol Advanced Patient Information, Salbutamolum

Salbutamol (Inhalation)

Accuneb

ProAir HFA

Proair Respiclick

Proventil

Proventil HFA

ReliOn Ventolin HFA

Ventolin

Ventolin HFA

Alti-Salbutamol Inhalation Aerosol

Apo-Salvent

Salbutamol

Salbutamol Nebuamp

Salbutamol Respirator Solution

Ventolin Inhaler

Ventolin Nebules P. F.

Ventolin Respirator

Ventolin Rotacaps

Available Dosage Forms:

Therapeutic Class: Bronchodilator

Pharmacologic Class: Sympathomimetic

Uses For Salbutamol

Albuterol is used to treat or prevent bronchospasm in patients with asthma, bronchitis, emphysema, and other lung diseases. This medicine is also used to prevent wheezing caused by exercise (exercise-induced bronchospasm).

Albuterol belongs to the family of medicines known as adrenergic bronchodilators. Adrenergic bronchodilators are medicines that are breathed in through the mouth to open up the bronchial tubes (air passages) in the lungs. They relieve cough, wheezing, shortness of breath, and troubled breathing by increasing the flow of air through the bronchial tubes.

This medicine is available only with your doctor's prescription.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, albuterol is used in certain patients with the following medical condition:

Hyperkalemia (too much potassium in the blood).

Before Using Salbutamol

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of albuterol inhalation aerosol (eg, Proair® HFA) in children 4 years of age and older, albuterol inhalation powder (eg, Proair® Respiclick™) in children 12 years of age and older, and albuterol inhalation solution (eg, Accuneb®) in children 2 years of age and older. However, safety and efficacy have not been established for the albuterol inhalation aerosol in children younger than 4 years of age, albuterol inhalation powder in children younger than 12 years of age, and albuterol inhalation solution in children younger than 2 years of age.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of albuterol inhalation aerosol (eg, Proair® HFA) and albuterol inhalation powder (eg, Proair® Respiclick™) in geriatric patients. However, elderly patients are more likely to have age-related heart, kidney, or liver problems, which may require caution and an adjustment in the dose for patients receiving albuterol inhalation aerosol and albuterol inhalation powder .

No information is available on the relationship of age to the effects of albuterol inhalation solution (eg, Accuneb®) in geriatric patients.

Pregnancy

Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acebutolol

Amineptine

Amitriptyline

Amitriptylinoxide

Amoxapine

Atenolol

Atomoxetine

Befunolol

Betaxolol

Bevantolol

Bisoprolol

Bopindolol

Carteolol

Carvedilol

Celiprolol

Clomipramine

Desipramine

Dibenzepin

Doxepin

Esmolol

Furazolidone

Imipramine

Iobenguane I 123

Iproniazid

Isocarboxazid

Labetalol

Landiolol

Levalbuterol

Levobunolol

Linezolid

Lofepramine

Melitracen

Mepindolol

Methylene Blue

Metipranolol

Metoprolol

Moclobemide

Nadolol

Nebivolol

Nipradilol

Nortriptyline

Opipramol

Oxprenolol

Pargyline

Penbutolol

Phenelzine

Pindolol

Procarbazine

Propranolol

Protriptyline

Rasagiline

Selegiline

Sotalol

Talinolol

Tertatolol

Tianeptine

Timolol

Tranylcypromine

Trimipramine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

Allergy to milk proteins, history or—Proair® Respiclick™ should not be used in patients with this condition.

Diabetes or

Heart or blood vessel disease or

Heart rhythm problems (eg, arrhythmia) or

Hypertension (high blood pressure) or

Hyperthyroidism (overactive thyroid) or

Hypokalemia (low potassium in the blood) or

Seizures, history of—Use with caution. May make these conditions worse.

Kidney disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Proper Use of albuterol

This section provides information on the proper use of a number of products that contain albuterol. It may not be specific to Salbutamol. Please read with care.

Use this medicine only as directed by your doctor . Do not use more of it and do not use it more often than your doctor ordered. Also, do not stop using this medicine or any asthma medicine without telling your doctor. To do so may increase the chance for breathing problems.

The albuterol inhalation solution (eg, Accuneb®) should be used with a jet nebulizer that is connected to an air compressor with good air flow. The inhalation solution and nebulizer will come with patient instructions. Read and follow these instructions carefully. Ask your doctor if you have any questions.

To use the inhalation solution in the nebulizer :

Use one container of solution or mix the exact amount of solution using the dropper provided for each dose.

Place the inhalation solution in the medicine reservoir or nebulizer cup on the machine.

Connect the nebulizer to the face mask or mouthpiece.

Use the face mask or mouthpiece to breathe in the medicine.

Use the nebulizer for about 5 to 15 minutes, or until the medicine in the nebulizer cup is gone.

Clean all the parts of the nebulizer after each use.

The albuterol inhalation aerosol (eg, Proair® HFA) and albuterol inhalation powder (eg, Proair® Respiclick™) is used with a special inhaler that comes with patient instructions. Read the directions carefully before using this medicine. If you or your child do not understand the directions or are not sure how to use the inhaler, ask your doctor to show you what to do. Also, ask your doctor to check you or your child on a regular basis to make sure you are using it properly.

To use the inhalation aerosol :

The inhaler should be at room temperature before you use it.

Insert the metal canister firmly and fully into the clear end of the Proair® HFA mouthpiece. This mouthpiece should not be used with other inhaled medicines.

Remove the cap and look at the mouthpiece to make sure it is clean.

Shake the inhaler well and test spray it in the air 3 times before using it for the first time or if the inhaler has not been used for more than 2 weeks.

To inhale this medicine, breathe out fully, trying to get as much air out of the lungs as possible. Put the mouthpiece just in front of your mouth with the canister upright.

Open your mouth and breathe in slowly and deeply (like yawning), and at the same time firmly press down once on the top of the canister.

Hold your breath for about 10 seconds, then breathe out slowly.

If you are supposed to use more than one puff, wait 1 minute before inhaling the second puff. Repeat these steps for the second puff, starting with shaking the inhaler.

When you have finished all of your doses, rinse your mouth with water and spit the water out.

Clean the inhaler mouthpiece at least once a week with warm running water for 30 seconds, and dry it completely.

If you need to use the inhaler before it is completely dry, shake off the excess water, replace the canister, and spray it 2 times in the air away from the face. Use your regular dose.

After using the inhaler, wash the mouthpiece again and dry it completely.

If the mouthpiece becomes blocked, washing it will help.

To use the inhalation powder :

Take the inhaler from the foil pouch before you use it for the first time.

The inhaler provides about 200 inhalations. The dose counter will change to red when there are "20" doses left. Call your doctor or pharmacist for a refill of prescription or medicine.

Make sure the cap is closed before using this medicine. Do not open the cap unless you are going to use it.

Hold the inhaler upright as you open the cap fully until you hear a "click". Your inhaler is now ready to use.

To inhale this medicine, breathe out fully, trying to get as much air out of the lungs as possible. Put the mouthpiece fully into your mouth and close your lips around it.

Breathe in through your mouth as deeply as you can until you have taken a full deep breath.

Do not block the vent above the mouthpiece with your lips or fingers.

Hold your breath for about 10 seconds or as long as you comfortably can.

Remove the inhaler from your mouth and check the dose counter to make sure you received the medicine.

Close the cap firmly over the mouthpiece after using the inhaler. Always close the cap after each use.

If you are supposed to use more than one puff, repeat these steps for the second puff, starting with opening the cap fully.

Keep the inhaler clean and dry at all times. Do not wash or put any part of the inhaler in water.

If you need to clean the mouthpiece, wipe it gently with a dry cloth or tissue.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For inhalation aerosol dosage form (inhaler):

For treatment or prevention of bronchospasm:

Adults, teenagers, and children 4 years of age and older—Two puffs every 4 to 6 hours as needed.

Children younger than 4 years of age—Use and dose must be determined by your child's doctor.

For prevention of exercise-induced bronchospasm:

Adults, teenagers, and children 4 years of age and older—Two puffs taken 15 to 30 minutes before exercise.

Children younger than 4 years of age—Use and dose must be determined by your child's doctor.

For inhalation powder dosage form (inhaler):

For treatment or prevention of bronchospasm:

Adults, teenagers, and children 12 years of age and older—Two puffs every 4 to 6 hours as needed.

Children younger than 12 years of age—Use and dose must be determined by your child's doctor.

For prevention of exercise-induced bronchospasm:

Adults, teenagers, and children 12 years of age and older—Two puffs taken 15 to 30 minutes before exercise.

Children younger than 12 years of age—Use and dose must be determined by your child's doctor.

For inhalation solution dosage form (used with a nebulizer):

For prevention of bronchospasm:

Adults and children older than 12 years of age—2.5 milligrams (mg) in the nebulizer 3 or 4 times per day as needed.

Children 2 to 12 years of age—0.63 to 1.25 mg in the nebulizer 3 or 4 times per day as needed.

Children younger than 2 years of age—Use and dose must be determined by your child's doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the canister at room temperature, away from heat and direct light. Do not freeze. Do not keep this medicine inside a car where it could be exposed to extreme heat or cold. Do not poke holes in the canister or throw it into a fire, even if the canister is empty.

Keep the medicine in the foil pouch until you are ready to use it. Store at room temperature, away from heat and direct light. Do not freeze.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Throw away Proair® Respiclick™ 13 months after opening the foil pouch, when the dose counter reaches "0", or after the expiration date, whichever comes first.

Precautions While Using Salbutamol

It is very important that your doctor check the progress of you or your child at regular visits . This will allow your doctor to see if the medicine is working properly and to check for any unwanted effects.

This medicine should not be used together with other inhaled medicines that are similar, such as isoproterenol (Isuprel®), levalbuterol (Xopenex™), metaproterenol (Alupent®), pirbuterol (Maxair®), or terbutaline (Brethaire®).

This medicine may cause paradoxical bronchospasm, which means your breathing or wheezing will get worse. Paradoxical bronchospasm may be life-threatening. Check with your doctor right away if you or your child have coughing, difficulty breathing, shortness of breath, or wheezing after using this medicine.

Talk to your doctor or get medical help right away if:

Your symptoms do not improve or they become worse after using this medicine.

Your inhaler does not seem to be working as well as usual and you need to use it more often.

You or your child may also be taking an antiinflammatory medicine, such as a steroid (cortisone-like medicine), together with this medicine. Do not stop taking the antiinflammatory medicine, even if your asthma seems better, unless you are told to do so by your doctor.

Albuterol may cause serious types of allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Check with your doctor right away if you or your child develop a skin rash, hives, itching, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using this medicine.

Hypokalemia (low potassium in the blood) may occur while you are using this medicine. Check with your doctor right away if you or your child have more than one of the following symptoms: convulsions, decreased urine, dry mouth, increased thirst, irregular heartbeat, loss of appetite, mood changes, muscle pain or cramps, nausea or vomiting, numbness or tingling in the hands, feet, or lips, shortness of breath, or unusual tiredness or weakness.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, and herbal or vitamin supplements.

Salbutamol Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Fast, irregular, pounding, or racing heartbeat or pulse

shakiness in the legs, arms, hands, or feet

trembling or shaking of the hands or feet

Less common

Abdominal or stomach pain

bladder pain

bloody or cloudy urine

chest discomfort

chest pain

cough or hoarseness

cough producing mucus

diarrhea

difficult or labored breathing

difficulty with swallowing

dizziness

feeling of warmth

fever or chills

frequent urge to urinate

hives

itching

loss of appetite

lower back or side pain

nausea

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

redness of the face, neck, arms, and occasionally, upper chest

runny nose

shortness of breath

skin rash

sore throat

swollen, painful, or tender lymph glands in the neck, armpit, or groin

tightness in the chest

unusual tiredness or weakness

weakness

Rare

Hives or welts

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

noisy breathing

redness of the skin

swelling of the mouth or throat

trouble breathing

Incidence not known

Agitation

anxiety

arm, back, or jaw pain

chest tightness or heaviness

confusion

convulsions

decreased urine

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

drowsiness

dry mouth

extra heartbeats

fainting

flushed, dry skin

fruit-like breath odor

hallucinations

headache

increased hunger

increased thirst

increased urination

irritability

lightheadedness

muscle pain or cramps

nervousness

nightmares

numbness or tingling in the hands, feet, or lips

pounding in the ears

rapid, deep breathing

restlessness

shakiness

slow or fast heartbeat

stomach cramps

sweating

unexplained weight loss

unusual feeling of excitement

vomiting

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Body aches or pain

congestion

fever

runny nose

tender, swollen glands in the neck

trouble with swallowing

voice changes

Less common

Difficult, burning, or painful urination

earache

headache, severe and throbbing

muscle or bone pain

pain

redness of the skin

redness or swelling in the ear

redness, swelling, or soreness of the tongue

sleeplessness

sneezing

stuffy nose

swelling

tenderness

trouble in holding or releasing urine

trouble sleeping

unable to sleep

warmth on the skin

Rare

Sleepiness or unusual drowsiness

Incidence not known

Bad, unusual, or unpleasant (after) taste

change in taste

feeling of constant movement of self or surroundings

gagging

rough, scratchy sound to voice

sensation of spinning

tightness in the throat

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Truven Health Micromedex products as delivered by Drugs. com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs. com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products.

Copyright 2016 Truven Health Analytics, Inc. All Rights Reserved.

National Counterterrorism Center, Hartam

BACKGROUND

Boko Haram, which refers to itself as “Jama‘atu Ahl as-Sunnah li-Da‘awati wal-Jihad” (JASDJ; Group of the Sunni People for the Calling and Jihad) and “Nigerian Taliban”—other translations and variants are used—is a Nigeria-based group that seeks to overthrow the current Nigerian Government and replace it with a regime based on Islamic law. It is popularly known in Nigerian and Western media as “Boko Haram,” which means “Western education is forbidden” (the word boko is a holdover from the colonial English word for book). The group, which has existed in various forms since the late 1990s, suffered setbacks in July 2009 when clashes with Nigerian Government forces led to the deaths of hundreds of its members, including former leader Muhammad Yusuf.

In July 2010, Boko Haram’s former second-in-command, Abubakar Shekau, appeared in a video claiming leadership of the group and threatening attacks on Western influences in Nigeria. Later that month, Shekau issued a second statement expressing solidarity with al-Qa‘ida and threatening the United States. Under Shekau’s leadership, the group has continued to demonstrate growing operational capabilities, with an increasing use of improvised explosive device (IED), vehicle-borne IED (VBIED), and female suicide attacks against a wide range of targets. The group set off its first VBIED in June 2011. On 26 August 2011, Boko Haram conducted its first attack against a Western interest—a vehicle-bomb attack on UN headquarters in Abuja—killing at least 23 people and injuring more than 80. A purported Boko Haram spokesman claimed responsibility for the attack and promised future targeting of US and Nigerian Government interests.

Boko Haram’s capability increased in 2014, with the group conducting near-daily attacks against Christians, security and police forces, the media, schools, politicians, and Muslims perceived as collaborators. Boko Haram continued to raise its international profile in 2015, pledging allegiance to the Islamic State in Iraq and the Levant (ISIL) in March—and publicly using the name “ISIL-West Africa Province” and similar variants—and conducting simultaneous suicide bombings in N’Djamena, Chad, in June—the first such attack in that country’s capital.

Boko Haram’s violence—including the kidnapping of 276 schoolgirls in Borno State, Nigeria, in April 2014—brought international condemnation and in February 2015 provoked a large regional CT offensive against the group that displaced it from the majority of its strongholds in Nigeria. Nonetheless, Boko Haram remains resilient, conducting attacks in neighboring Cameroon, Chad, Niger, as well as Nigeria, emphasizing the threat it poses to Western and regional interests.

The US State Department designated Boko Haram a Foreign Terrorist Organization in November 2013.

Spelling of arabic names and terms

While there is no universally accepted transliteration of Arabic names and terms, this edition of the Counterterrorism Calendar adheres to a transliteration system that is generally used throughout the US Government. In this system, the letters “u” and “a” are preferred over “o” and “e.” For example, the name of the al-Qa‘ida operative who was detained on 1 March 2003 is Khalid Shaykh Muhammad, not Khalid Sheikh Mohammed; he was an associate of Usama Bin Ladin, not Osama Bin Laden. We have retained, however, the spellings used on the Rewards for Justice and FBI terrorism sites; spellings there are designed for easy recognition or are used in legal documents and therefore do not always conform to these rules.

Islamic calendar

The Islamic calendar is based on the movement and observation of the moon. The Islamic year contains 12 months, none of which can exceed 30 days. Each month starts when the lunar crescent is first seen after a new moon. Because 12 lunar months multiplied by 29.53 days equals 354.36 days, the Islamic calendar will always be approximately 11 days shorter than the Western (Gregorian) calendar. For example, 1 Muharram, the first day of Islamic year 1437 (known in the West by the Latin term Anno Hegirae, or A. H.), fell on 14 October 2015; in A. H. 1438, 1 Muharram falls on 2 October 2016. Because of lunar observation and differences in time zones, the observance of Islamic holidays and calendar dates may vary from region to region. Islamic dates and holidays are approximate, as they are determined by local lunar observation. Islamic and Jewish holidays begin the evening preceding the date shown unless stated otherwise.

Map boundaries

Boundary representation is not necessarily authoritative.

The information on this website is valid as of 29 August 2015. This website contains only information in the public domain that has been verified and disseminated by US Government sources.

Melovis 15 Mg ~ Pribalovy Letak, Skupina, Ucinky, Melovis

Melovis 15 Mg

Priloha k sp. zn. sukls163867/2011a priloha k sp. zn. sukls92132/2011

PRIBALOVA INFORMACE-INFORMACE PRO UZIVATELE

MELOVIS 15 mgTablety Meloxicamum

Prectete si prosim pozorne celou pribalovou informaci drive, nez zacnete tento pripravek uzivat. - Ponechte si pribalovou informaci pro pripad, ze si ji budete potrebovat precist znovu.- Mate-li jakekoli dalsi otazky, zeptejte se, prosim, sveho lekare nebo lekarnika.- Tento pripravek byl predepsan Vam, a proto jej nedavejte zadne dalsi osobe. Mohl by ji ublizit, a to i tehdy, ma-li stejne priznaky jako Vy. - Pokud se kterykoli z nezadoucich ucinku vyskytne v zavazne mire, nebo pokud si vsimnete jakychkoli nezadoucich ucinku, ktere nejsou uvedeny v teto pribalove informaci, prosim, sdelte svemu lekari nebo lekarnikovi.

V pribalove informaci naleznete: 1. Co je MELOVIS a k cemu se pouziva2. Cemu musite venovat pozornost, nez zacnete pripravek MELOVIS uzivat3. Jak se pripravek MELOVIS uziva4. Mozne nezadouci ucinky5. Jak pripravek MELOVIS uchovavat6. Dalsi informace

1. CO JE MELOVIS A K CEMU SE POUZIVA

Meloxicam je zanety tlumici lecivo s analgetickym ucinkem (NSAID: nesteroidni lecivo s protizanetlivym ucinkem) snizujici aktivitu bunek lidskeho imunitniho systemu, ktere jsou zodpovedne za vznik zanetu. Onemocneni se tedy zmirnuje a zanet se zmensuje. Otoky kloubu, ztuhlost a bolest se snizuji nebo uplne mizi. Melovis neleci revmatismus, ale zastavi vyvoj onemocneni.

MELOVIS se pouziva

ke kratkodobe lecbe bolesti pri akutnim zhorseni degradace chrupavky v kloubech

k dlouhodobemu leceni bolesti pri zanetlivych onemocnenich, ktere postihuji predevsim klouby (revmatoidni artritida) k lecbe bolesti pri chronickych zanetech malych kloubu mezi obratli vedouci k ztuhnuti zad

Vas lekar muze predepsat i jine vyuziti. Postupujte prosim podle pokynu sveho lekare.

2. CEMU MUSITE VENOVAT POZORNOST, NEZ ZACNETE PRIPRAVEK MELOVIS UZIVAT

Neuzivejte MELOVIS pokud:

jste precitliveli (alergicti) na meloxicam (leciva latka) nebo na kteroukoli pomocnou latku

obsazenou v pripravku MELOVIS nebo lecivou latku s podobnym ucinkem, napr. protizanetlive leky a

jste tehotna nebo planujete tehotenstvi nebo kojeni

mate astma, polypy v nose, trpite otoky, zpusobenymi alergii nebo koprivkou po poziti kyseliny acetylsalicylove nebo jinych protizanetlivych leku

mate aktivni vred nebo recidivujici vred zaludku nebo dvanactniku

trpite zavaznou poruchou funkce jater

trpite zavaznou poruchou funkce ledvin

mate zaludecni vred nebo dvanactnikovy vred nebo krvaceni do mozku nebo jine poruchy spojene s krvacenim

trpite zavaznym srdecnim selhanim

mate gastrointestinalni krvaceni nebo perforaci vredu, pepticky vred nebo krvaceni z vredu. Zvlastni opatrnosti pri pouziti pripravku MELOVIS je zapotrebi

Leky jako je pripravek MELOVIS mohou vest k mirnemu zvyseni rizika srdecniho zachvatu ("infarkt myokardu") nebo mozkove mrtvice (cevni mozkove prihody). Takove nebezpeci je vzdy pravdepodobnejsi u vysokych davek a dlouhodobejsiho podavani. Neprekracujte proto doporucene davkovani ani delku lecby.

Pokud trpite srdecnimi potizemi, prodelali jste mozkovou mrtvici (cevni mozkovou prihodu) nebo se domnivate, ze byste jimi mohli byt ohrozeni (napr. mate vysoky krevni tlak, diabetes/cukrovku, vysokou hladinu cholesterolu nebo jste kurak/kuracka), meli byste se o lecbe poradit s lekarem nebo lekarnikem.

Drive nez zacnete uzivat pripravek MELOVIS informujte sveho lekare ze:

trpite srdecnim selhanim, vysokym krevnim tlakem nebo postizenim funkce jater ci ledvin nebo pokud chodite na dialyzu

jste mel/a vred jicnu, zaludku nebo duodenalni vred

trpite gastrointestinalni dysfunkci (zaludecnimi ci strevnimi obtizemi)

mate poruchu, spojenou s krvacenim nebo jste nekdy trpeli krvacenim do zaludku nebo strev nebo krvacenim do mozku

mate nejakou mozkovou poruchu

trpite onemocnenim perifernich tepen

jiz berete nejaka analgetika

pokud u Vas doslo ke snizeni krevniho objemu (napr. po tezke operaci).

mate hypovolemii (snizeni objemu obihajici krve), ktera se muze vyskytnout po ztrate krve, pri popaleninach, po operaci nebo pri nizkem prijmu tekutin

mate vysoky krevni tlak a/nebo trpite mestnavym srdecnim selhanim

jste zena a chtela byste otehotnet.

Lecbu je nutno prerusit po konzultaci s lekarem, pokud

dojde ke krvaceni z traviciho ustroji nebo z vredu

se objevi zavazne kozni reakce nebo jine alergicke reakce, napriklad dusnost

se objevi infekce ledvin nebo ledvinne panvicky

mate zvysenou hladinu transaminazy, bilirubinu nebo jinych hodnot jaternich testu, zvysenou hladinu kreatininu a mocoviny stejne jako zmenene vysledky laboratornich vysetreni, ktere mohou byt vyznamne a trvale.

Pacienti s anamnezou gastrointestinalni toxicity, zvlaste pokud jde o starsi pacienty, musi hlasit jakekoli nezvykle abdominalni priznaky (zejmena gastrointestinalni krvaceni), a to zejmena na pocatku lecby.

Opatrnost se doporucuje u pacientu uzivajicich soubezne leky, ktere by mohly zvysit riziko ulcerace nebo krvaceni, jako jsou peroralni kortikosteroidy, leky redici krev jako napr. warfarin, selektivni inhibitory zpetneho vychytavani serotoninu nebo antiagregancia (leky pusobici proti srazeni krve) jako je kyselina acetylsalicylova.

Starsi pacienti Pokud trpite snizenou funkci ledvin, jater nebo srdecni nedostatecnosti, pokud chodite na dialyzu nebo jste podstoupili velky chirurgicky zakrok, je nezbytne zajistit behem lecby pripravkem MELOVIS peclivou kontrolu funkce ledvin. Vedlejsi ucinky pripravku jsou hure tolerovany u starsich pacientu, kteri maji zvyseny vyskyt nezadoucich ucinku, zejmena gastrointestinalni krvaceni nebo perforace, ktere mohou byt smrtelne..

Laboratorni vysledky Pri vysetreni krve informujte lekare, ze uzivate pripravek MELOVIS, protoze pripravek muze ovlivnit vysledky nekterych testu.

Vzajemne pusobeni s dalsimi lecivymi pripravky Prosim, informujte sveho lekare nebo lekarnika o vsech lecich, ktere uzivate nebo jste uzivali v nedavne dobe. vcetne leku bez lekarskeho predpisu.

Poradte se se svym lekarem, protoze bude mozna nutno upravit davkovani.

Opatrne je nutno postupovat pri soucasnem uzivani

jinych pripravku k lecbe revmatismu (napr. metotrexatu), ktere mohou zpusobit zmenu krevnich bunek

jinych analgetik, ktera mohou zvysit riziko gastrointestinalniho krvaceni

leku, ktere rozpousteji krevni srazeniny nebo leku zabranujicich srazlivosti krve (napr.

pentoxifylin), protoze hrozi zvysene nebezpeci krvaceni -

lithia (proti depresim), protoze se muze zvysit koncentrace lithia v krvi

cyclosporinu (antibiotikum), kde muze dojit k poklesu funkce ledvin

diuretik (pri nedostatecnem prijmu tekutin hrozi nebezpeci akutniho selhani ledvin)

zidovudinu (proti AIDS), coz muze vyvolat anemii

nitrodelozniho teliska (DANA), protoze by se jeho ucinek mohl snizit

tablet pri lecbe diabetu

kortikosteroidu, zvysuji riziko vzniku vredu a krvaceni traviciho ustrojiantikoagulantu. NSAIDs mohou zvysit ucinky antikoagulancii jako je napr. warfarin

antiagregancii (protidestickove leky snizujici krevni srazlivost) a selektivnich inhibitoru

zpetneho vychytavani serotoninu - SSRI (leky proti depresi), zvysuji riziko krvaceni do zazivaciho traktu -

nekolika nesteroidnich protizanetlivych pripravku dohromady, protoze muze dojit ke zvyseni gastrointestinalho krvaceni

ACE inhibitoru, antagoniste receptoru angiotensinu II a jine leky na snizeni krevniho tlaku: protizanetlive leky, mohou snizit jejich ucinnost

cholestyraminu, ktery vyznamne urychluje vylucovani meloxicamu, takze jeho mnozstvi v krvi bude nizsi a zustane v krvi po kratsi dobu.

Jine lecive pripravky mohou ovlivnit ucinek pripravku MELOVIS a pripravek MELOVIS muze ovlivnovat ucinek jinych lecivych pripravku. Obvykle to neni dulezite. V pripade potreby Vam dalsi informace poda Vas lekar nebo lekarnik.

Pouzivani pripravku MELOVIS s jidlem a pitim Pripravek MELOVIS je nutno brat behem jidla a zapijet vodou nebo jinou vhodnou tekutinou.

Tehotenstvi a kojeni Poradte se svym lekarem nebo lekarnikem drive, nez zacnete uzivat jakykoli lek.

TehotenstviNepouzivejte pripravek MELOVIS, pokud jste tehotna.

V prubehu prvniho a druheho trimestru tehotenstvi smi byt pripravek MELOVIS podavan pouze pokud je to nezbytne nutne, v nejmensi mozne davce a nejkratsi nutne dobe. Pri pouzivani pripravku MELOVIS behem posledniho trimestru tehotenstvi muze dojit k zavaznemu poskozeni plodu, napriklad se mohou objevit problemy se srdcem nebo plicemi nebo muze dojit k intoxikaci, zpusobene snizenou funkci ledvin. Proto je MELOVIS v prubehu tretiho trimestru kontraindikovan. U matky se muze snizit aktivita porodnich bolesti.

KojeniPripravek MELOVIS je vylucovan do materskeho mleka. Proto nesmi byt tento lek pouzivan behem kojeni.

Rizeni dopravnich prostredku a obsluha stroju Pri pouzivani pripravku MELOVIS se mohou objevit vedlejsi ucinky, ktere mohou vice nebo mene ovlivnit bezpecnost prace a schopnost ridit.

Dulezite informace o nekterych slozkach pripravku MELOVIS Pripravek MELOVIS obsahuje mlecny cukr (laktozu).

Pokud Vam lekar rekl, ze nesnasite urcite druhy cukru, informujte ho drive, nez zacnete pripravek MELOVIS uzivat.

3. JAK SE PRIPRAVEK MELOVIS UZIVA

Vzdy uzivejte pripravek presne podle pokynu sveho lekare. Pokud si nejste jisty/a, poradte se se svym lekarem nebo lekarnikem.

Celkovou denni davku, tj. jednu davku, uzijte vzdy behem jidla a zapijte ji vodou nebo jinou vhodnou tekutinou.

O uprave davkovani nebo preruseni lecby by mel vzdy rozhodnout Vas lekar.

Dospeli Kratkodoba lecba bolesti pri akutnim vzplanuti destrukce kloubni chrupavky (osteoartroza)Pul tablety 15 mg denne. Pokud se nedostavi ucinek, davka se muze zvysit na 1 tabletu 15 mg.

Dlouhodoba lecba bolesti zanetlivych onemocneni, postihujicich predevsim klouby (revmatoidni artritida)1 tableta 15 mg denne.

Lecba bolesti pri chronickem zanetu obratlu, majici za nasledek strnulost zad1 tableta 15 mg denne.

NIKDY NEPREKRACUJTE DAVKU 15 MG DENNE (odpovida 1 tablete 15 mg).

Starsi pacienti a pacienti se zvysenym rizikem vedlejsich ucinku

K dlouhodobe lecbe revmatoidni artritidy a ankylozujici spondylitidy (zanetu obratlu) u starsich pacientu se doporucuje davka 7,5 mg denne. Take pacienti s vysokym rizikem nezadoucich ucinku by meli zacit lecbu s davkou 7,5 mg meloxikamu denne.

Deti ve veku do 15 let U deti do 15 let se neprovadely zkousky bezpecnosti a ucinnosti lecby, proto se pripravek pro tuto vekovou skupinu nepouziva.

Porucha funkce ledvin a jater Je nutna uprava davky. Dodrzujte pokyny sveho lekare.

Pacienti na dialyze: denni davka nesmi prekrocit 7,5 mg (odpovida ? tablety 15 mg).

Pripravek Melovis se pacientum s tezkym poskozenim funkce ledvin a jater nesmi podavat!!

Jestlize jste pouzil/a vice pripravku MELOVIS, nez jste mel/a? Pokud jste uzil/a vice pripravku MELOVIS, nez je uvedeno v teto pribalove informaci nebo vice, nez Vam predepsal lekar, informujte okamzite sveho lekare, pohotovostni sluzbu nebo lekarnika.

Jestlize jste zapomnel/a uzit pripravek MELOVIS? Pokud jste zapomnel/a pouzit jednu davku pripravku, nezdvojujte nasledujici davku, abyste nahradil/a vynechanou davku. Pokracujte v lecbe dle pokynu sveho lekare. Mate-li jakekoliv dalsi otazky, tykajici se uzivani tohoto pripravku, zeptejte se sveho lekare nebo lekarnika.

4. MOZNE NEZADOUCI UCINKY

Podobne jako vsechny leky muze mit i pripravek MELOVIS nezadouci ucinky, ktere se ale nemusi vyskytnout u kazdeho.

Nejcasteji pozorovane nezadouci ucinky se tykaji zazivaciho traktu. Mohou se vyskytnout pepticke vredy, perforace vredu nebo krvaceni do zazivaciho traktu, ktere mohou byt nekdy az smrtelne, zejmena u starsichpacientu. Po podani leku byly hlaseny:nevolnost (nauzea), zvraceni, prujem, zvyseny odchod strevnich plynu(flatulence), zacpa, poruchy traveni (dyspepsie), bolesti bricha, krev ve stolici (melena), zvraceni krve (hematoemesis), ulcerozni zanet sliznice dutiny ustni (stomatitida), nove vzplanuti zanetu tracniku a Crohnova choroba (zanetlive strevni onemocneni). Mene casto se vyskytl zanet zaludku (gastritida).

Nezadouci ucinky byly serazeny podle frekvence vyskytu dle nasledujici zavedene klasifikace:Velmi caste: vice nez 1 z 10 pacientu Caste: 1 az 10 ze 100 pacientu Mene caste: 1 az 10 z 1000 pacientu Vzacne: mene nez 1 az 10 z 10 000 pacientu Velmi vzacne: mene nez 1 z 10 000 pacientu. Neznama frekvence: nelze z dostupnych dat zjistit

Caste nezadouci ucinky

snizeni poctu cervenych krvinek (anemie),

zavrate, bolest hlavy,

dyspepsie (poruchy traveni), priznaky nevolnosti zvraceni,

bolest bricha, zacpa, flatulence (plynatost, nadymani), prujem,

KVALITATIVNI A KVANTITATIVNI SLOZENI

Meloxicamum 15 mg v 1 tablete.

Obsahuje monohydrat laktozy. Uplny seznam pomocnych latek, viz bod 6.1.

Melovis 15 mg: svetle zlute, kulate, bikonvexni tablety se zkosenymi hranami, z jedne strany s pulici ryhou, nad pulici ryhou vyrazeno „B“ a pod pulici ryhou vyrazeno „19“, z druhe strany hladke.

Kratkodoba symptomaticka lecba exacerbace osteoartrozy. Dlouhodoba symptomaticka lecba revmatoidni artritidy nebo ankylozujici spondylitidy.

Davkovani a zpusob podani

Peroralni podani Exacerbace osteoartrozy: 7,5 mg jednou denne (? tablety 15 mg). V pripade, ze se ucinek nedostavi, lze davku zvysit na 15 mg jednou denne (1 tableta 15 mg).

Revmatoidni artritida, ankylozujici spondylitida: 15 mg jednou denne (1 tableta 15 mg). (Viz tez "Zvlastni skupiny pacientu").V zavislosti na terapeutickem efektu lze davku snizit na 7,5 mg jednou denne (? tablety 15 mg).

NEPREKRACUJTE DENNI DAVKU 15 mgPripravek je treba uzit v jedne davce behem jidla a zapit jej vodou nebo jinou tekutinou.

Nezadouci ucinky lze minimalizovat podavanim nejnizsi ucinne davky po nejkratsi dobu nutnou ke zlepseni symptomu (viz bod 4.4).Potreba symptomaticke lecby a odpoved pacienta na lecbu se ma pravidelne vyhodnocovat, zejmena u pacientu s osteoartrozou.

Zvlastni skupiny pacientu Starsi pacienti a pacienti se zvysenym rizikem nezadoucich ucinku (viz bod 5.2) U starsich pacientu cini doporucena davka pri dlouhodobe lecbe revmatoidni artritidy a ankylozujici spondylitidy 7,5 mg denne. U pacientu se zvysenym rizikem nezadoucich ucinku je treba zahajit lecbu denni davkou 7,5 mg (viz bod 4.4).

Selhani ledvin (viz bod 5.2)

U dialyzovanych pacientu s tezkym selhanim ledvin nesmi denni davka prekrocit 7,5 mg. U pacientu s mirnym az stredne zavaznym selhanim ledvin (tj. u pacientu s clearance kreatininu presahujicim 25 ml/min) neni treba davku snizovat. (Pro pacienty s tezkym selhanim ledvin bez dialyzy viz bod 4.3).

Jaterni selhani U pacientu s mirnym az stredne zavaznym jaternim selhanim neni nutne davku snizovat. (Pro pacienty s tezce poskozenou jaterni funkci viz bod 4.3).

Deti Melovis se nema pouzivat u deti mladsich 15 let.

Melovis je kontraindikovan v nasledujicich pripadech:?

treti trimestr tehotenstvi a kojeni (viz bod 4.6 Tehotenstvi a kojeni)

precitlivelost na meloxikam nebo na kteroukoli z pomocnych latek nebo precitlivelost na latky s obdobnym ucinkem, napr. NSAID (nesteroidni antirevmatika) a acetylsalicylova kyselina. Melovis se nema podavat pacientum, u nichz se po poziti acetylsalicylove kyseliny nebo nesteroidnich protizanetlivych pripravku projevily symptomy astmatu, nosni polypy, angioneuroticky edem nebo koprivka

anamnesticky gastrointestinalni krvaceni nebo perforace ve vztahu k predchozi lecbe NSAID. Aktivni nebo anamnesticky rekurentni pepticky vred/hemoragie (dve nebo vice epizod prokazane ulcerace nebo krvaceni)

tezka porucha jaterni funkce

nedialyzovane tezke selhani ledvin

gastrointestinalni krvaceni, cerebrovaskularni krvaceni nebo jine krvacive poruchy

tezke srdecni selhani.

Zvlastni upozorneni a zvlastni opatreni pro pouziti

Je nutne se vyvarovat soucasneho pouzivani pripravku Melovis a NSAID vcetne selektivnich inhibitoru cyklooxygenazy-2.

Nezadouci ucinky lze minimalizovat pouzitim nejmensi ucinne davky po nejkratsi moznou dobu, ktera je nezbytna k lecbe priznaku.

Starsi pacientiU starsich pacientu byva zvysena frekvence nezadoucich reakci na NSAID, zejmena krvaceni do gastrointestinalniho traktu a perforace vredu, ktere mohou byt i smrtelne (viz bod 4.2).

Krvaceni do gastrointestinalniho traktu, ulcerace nebo perforace vreduU vsech NSAID, a to kdykoli behem lecby, bylo hlaseno krvaceni do gastrointestinalniho traktu, ulcerace nebo perforace vredu, ktere mohou byt smrtelne. Tyto prihody se vyskytovaly s varovnymi symptomy nebo bez nich, i bez predchozi anamnezy zavaznych gastrointestinalnich prihod.

Riziko krvaceni do gastrointestinalniho traktu, ulcerace nebo perforace vredu stoupa se zvysujici se davkou NSAID, u pacientu s anamnezou vredove choroby, zejmena jestlize byla komplikovana krvacenim nebo perforaci (viz bod 4.3) a u starsich osob. U techto pacientu ma byt zahajena lecbanejnizsi moznou davkou.

U techto pacientu a dale u pacientu, u nichz je nutna soubezna lecba nizkou davkou kyseliny acetylsalicylove nebo jinymi leky, u kterych je pravdepodobnost zvyseni gastrointestinalniho rizika, je nutne zvazit kombinacni lecbu protektivnimi latkami (napr. misoprostolem nebo inhibitory protonove pumpy) (viz nize a bod 4.5).Pacienti s anamnezou gastrointestinalni toxicity, a to zejmena starsi pacienti, musi byt pouceni, aby vcas hlasili kazde neobvykle gastrointestinalni symptomy (zejmena krvaceni do gastrointestinalniho traktu), obzvlaste v pocatecnim stadiu lecby.

Opatrnost je nutna u pacientu uzivajicich soubezne leky, ktere by mohly zvysit riziko ulcerace nebo krvaceni, jako jsou peroralni kortikosteroidy, antikoagulancia (napr. warfarin), selektivni inhibitory zpetneho vychytavani serotoninu nebo antiagregancia (napr. kyselina acetylsalicylova) (viz bod 4.5).

Jestlize se vyskytne krvaceni do gastrointestinalniho traktu u pacientu uzivajicich Melovis, musi byt lecba ukoncena.

NSAID je treba davat s opatrnosti pacientum s anamnezou gastrointestinalniho onemocneni (ulcerozni kolitida, Crohnova choroba), protoze muze dojit k exacerbaci choroby (viz bod 4.8).

Vysetrit je treba vsechny predchozi pripady esofagitidy, gastritidy a/nebo peptickeho vredu, aby se zjistilo, zda byl pacient pred zacatkem lecby meloxikamem zcela vylecen. Je treba mit neustale na pameti, ze u zminenych onemocneni muze dojit k jejich recidive, pokud je pacient, ktery jimi trpel, lecen meloxikamem.

Velmi vzacne byly v souvislosti s pouzivanim NSAID hlaseny zavazne kozni reakce, nektere z nich az smrtelne, jako je exfoliativni dermatitida, Stevens-Johnsonuv syndrom a toxicka epidermalni nekrolyza (viz bod 4.8). Pacienti maji zjevne nejvetsi riziko techto reakci na zacatku lecby. K nastupu techto reakci dochazi ve vetsine pripadu v prvnim mesici lecby. Melovis je nutne vysadit pri prvnim objeveni se vyrazky, sliznicnich lezi nebo jine znamky precitlivelosti.

NSAID mohou ve vzacnych pripadech vyvolat intersticialni nefritidu, glomerulonefritidu, renalni medularni nekrozu nebo nefroticky syndrom.

Podobne, jako vetsina NSAID, muze i Melovis vyvolat prechodne zvyseni hladin serovych transaminaz, zvyseni seroveho bilirubinu nebo jinych funkcnich jaternich testu, stejne jako zvyseni seroveho kreatininu a

mocoviny v krvi, i jine patologicke laboratorni nalezy. Ve vetsine

zminenych pripadu dochazi k prechodnym a lehkym odchylkam. Pokud se zjisti, ze odchylky jsou zavazne nebo pretrvavaji, je treba podavani meloxikamu prerusit a provest prislusna vysetreni.

Opatrnost je zapotrebi u pacientu s anamnezou hypertenze nebo mirneho az stredne zavazneho srdecniho selhani, protoze v souvislosti s lecbou NSAID byly hlaseny pripady retence tekutin a otoky.

Udaje z klinickych a epidemiologickych studii ukazuji, ze pouzivani nekterych NSAID (zejmena ve vysokych davkach a pri dlouhodobe lecbe) muze byt spojeno s mirne vyssim rizikem arterialnich trombotickych prihod (napr. infarktu myokardu nebo cevni mozkove prihody). Neexistuji dostatecne udaje, ktere by mohly vyloucit toto riziko pro meloxikam.

Podavani meloxikamu je treba peclive zvazit u pacientu s nekompenzovanou hypertenzi, srdecnim selhanim, diagnostikovanou ischemickou chorobou srdecni, ischemickou chorobou dolnich koncetin, pripadne cerebrovaskularnim postizenim. Podobne je treba zvazit zahajeni dlouhodobe lecby u pacientu s rizikovymi faktory kardiovaskularnich chorob (napr. hypertenze, hyperlipidemie, diabetes mellitus a koureni).

Funkcni selhani ledvinNSAID mohou inhibici vasodilatacniho ucinku renalnich prostaglandinu indukovat funkcni selhani ledvin snizenim glomerularni filtrace. Tento nezadouci ucinek zavisi na davce. Na zacatku lecby nebo po zvyseni davky se u pacientu s nize uvedenymi rizikovymi faktory doporucuje peclive sledovani diurezy a funkce ledvin:?

pri soubezne lecbe inhibitory ACE, antagonisty angiotensinu II, sartany, diuretiky (viz bod 4.5)

hypovolemie (jakehokoli puvodu)

tezka porucha funkce jater (serovy albumin < 25 g/l nebo Child-Pugh skore ?10).

Retence sodiku a vodyRetence sodiku a vody s moznosti tvorby otoku, vzniku hypertenze nebo zhorseni hypertenze, zhorsene srdecniho selhani. Pri hypertenzi nebo srdecnim selhani je nutne provadet co nejdrive po zahajeni lecby klinicke sledovani. Muze se objevit pokles antihypertenzniho ucinku (viz bod 4.5).

HyperkalemieHyperkalemii muze napomahat diabetes nebo soubezna lecba leky, o nichz je znamo, ze zvysuji hladiny kalia (viz bod 4.5). V techto pripadech je treba provadet pravidelne sledovani hladin kalia.

Nezadouci ucinky casto hure snaseji starsi, subtilni nebo oslabeni pacienti; ty je proto treba peclive sledovat. Stejne, jako u ostatnich NSAID, je nutne venovat zvlastni pozornost starsim pacientum, kteri maji casto narusenu funkci ledvin, jater a srdce.

Doporucena maximalni denni davka by se v pripade nedostatecneho terapeutickeho ucinku nemela prekracovat a terapie by ani nemela byt doplnovana o dalsi NSAID, protoze by mohlo dojit ke zvyseni toxicity, aniz by se dosahlo prokazatelneho terapeutickeho prinosu. Pokud se stav pacienta behem nekolika dnu nezlepsi, je treba znovu zvazit klinickou prospesnost lecby.

Po dlouhodobe lecbe analgetiky (dele nez 3 mesice), pokud se uzivaji obden nebo casteji, se muze objevit nebo zhorsit bolest hlavy. Bolesti hlavy zpusobene nadmernym uzivanim analgetik se nemaji lecit zvysenim jejich davek. V techto pripadech se maji analgetika po konzultaci s lekarem vysadit.

Meloxikam, stejne jako jina NSAID, muze maskovat symptomy probihajiciho infekcniho onemocneni.

Podobne jako u jinych leku, o nichz je znamo, ze potlacuji syntezu cyklooxygenazy/prostaglandinu, muze uzivani meloxikamu ovlivnit fertilitu, a proto se lecba pripravkem nedoporucuje u zen, ktere hodlaji otehotnet. U zen, ktere maji potize s otehotnenim nebo ktere se chteji nechat vysetrit pro neplodnost, je treba zvazit vysazeni meloxikamu.

Opatrnost je nutna pri podavani meloxikamu pacientum s bronchialnim astmatem nebo anamnezou teto choroby, protoze existuje moznost, ze NSAID mohou u techto pacientu zpusobit bronchospazmus.

Pacienti se vzacnymi vrozenymi chorobami, jako je nesnasenlivost galaktozy, vrozenym deficitem laktazy nebo s malabsorpci glukozy-galaktozy by tento lek nemeli uzivat.

Interakce s jinymi lecivy a jine formy interakce

Farmakodynamicke interakce Ostatni NSAID pripravky vcetne salicylatu Pri soucasnem podavani nekolika NSAID se muze zvysit nebezpeci vzniku gastrointestinalnich vredu a krvaceni v dusledku synergickeho ucinku. Soucasna lecba meloxikamem a dalsimi NSAID se nedoporucuje (viz bod 4.4).

Diuretika, inhibitory ACE a antagoniste angiotensinu II NSAID mohou snizovat ucinek diuretik a dalsich antihypertenziv. U nekterych pacientu s poruchou funkce ledvin (napr. dehydratovani pacienti nebo starsi pacienti s poruchou funkce ledvin) muze kombinace inhibitoru ACE nebo antagonistu angiotensinu II a latek inhibujicich cyklooxygenazu vest k dalsimu zhorseni funkce ledvin, vcetne mozneho akutniho selhani ledvin, ktere je obvykle reverzibilni. Tuto kombinaci je treba proto podavat s opatrnosti, a to zejmena u starsich pacientu. Pacienti by meli byt adekvatne hydratovani a po zahajeni soucasne lecby by melo byt zvazeno sledovani funkce ledvin, ktere by melo byt dale provadeno v pravidelnych intervalech (viz bod 4.4).

Ostatni antihypertenziva (napr. beta-blokatory) Podobne, jako u posledne zminenych latek, muze dojit k poklesu antihypertenzniho ucinku beta-blokatoru (v dusledku inhibice prostaglandinu s vasodilatacnimi ucinky).

Cyklosporiny NSAID mohou zvysit nefrotoxicky ucinek cyklosporinu v dusledku ucinku, zpusobeneho prostaglandiny. Behem kombinovane lecby je treba sledovat a merit renalni funkce. Doporucuje se peclive sledovat renalni funkce zvlaste u starsich pacientu.

Nitrodelozni teliska Uvadi se, ze NSAID jsou schopny snizit ucinnost nitrodelozniho teliska. Pokles ucinnosti nitrodeloznich telisek, apod. v dusledku uzivani NSAID byl jiz zminovan v minulosti. Tato problematika vyzaduje dalsi zkoumani.

Kortikosteroidy Zvysene riziko gastrointestinalnich vredu nebo krvaceni (viz bod 4.4).

Antikoagulancia NSAID mohou zvysit ucinky antikoagulancii, napr. warfarinu (viz bod 4.4). Pokud neni mozne se tetokombinaci vyhnout, je nutne peclive sledovani INR.

Antiagregancia a selektivni inhibitory zpetneho vychytavani serotoninu (SSRI) Zvysene riziko krvaceni do gastrointestinalniho traktu (viz bod 4.4).

Farmakokineticke interakce (ucinek meloxikamu na farmakokinetiku jinych leku)

Lithium Uvadi se, ze NSAID zvysuji hladiny lithia v krvi (v dusledku snizeneho renalniho vylucovani lithia), ktere mohou dosahnout toxickych hodnot. Soucasna lecba lithiem a NSAID se nedoporucuje (viz bod 4.4). Pokud je nutno takovou kombinaci pripravku pouzit, je treba peclive sledovat koncentraci lithia v plazme na zacatku a pri ukonceni lecby.

Methotrexat NSAID mohou snizit tubularni sekreci methotrexatu, cimz se zvysi jeho koncentrace v plazme. Soucasna lecba NSAID se proto nedoporucuje u pacientu, lecenych vysokymi davkami methotrexatu (vice nez 15 mg/tyden) (viz bod 4.4).Riziko interakce mezi NSAID a methotrexatem je treba tez zvazovat u pacientu, uzivajicich nizke davky methotrexatu, zvlaste pokud trpi poruchou renalni funkce. V pripade, ze je kombinovana lecba nezbytna, je treba sledovat krevni obraz a funkci ledvin. Pozornost je treba venovat pripadum, kdy se NSAID i methotrexat aplikuji v rozmezi 3 dnu, protoze hladina methotrexatu v plazme se muze zvysit a zpusobit zvysenou toxicitu.

I kdyz farmakokinetika methotrexatu (15 mg/tyden) nebyla vyznamne ovlivnena soucasnympodavanim meloxikamu, je treba mit na pameti, ze hematologicka toxicita methotrexatu se muze v dusledku lecby NSAID zvysit (viz vyse). (Viz bod 4.8).

Farmakokineticke interakce (ucinek jinych leku na farmakokinetiku meloxikamu)

Cholestyramin Cholestyramin urychluje vylucovani meloxikamu tim, ze prerusuje jeho enterohepatalni cirkulaci, takze clearance meloxikamu se zvysuje o 50% a polocas se snizuje na 13?3 hodiny. Zminena interakce je klinicky vyznamna.

Nebyly zjisteny zadne klinicky relevantni farmakokineticke interakce mezi jednotlivymi leky s ohledem na soucasne podavani antacid, cimetidinu a digoxinu. 4.6

Tehotenstvi a kojeni

Tehotenstvi Inhibice syntezy prostaglandinu muze nezadoucim zpusobem ovlivnit tehotenstvi a/nebo vyvoj embrya ci plodu. Udaje z epidemiologickych studii naznacuji zvysene riziko spontanniho potratu, malformaci srdce a gastroschizy po podani inhibitoru syntezy prostaglandinu na zacatku gravidity. Absolutni riziko kardiovaskularnich vad se zvysilo z mene nez 1% na priblizne 1,5%. Riziko se muze zvysit s davkou a delkou lecby. Podani inhibitoru syntezy prostaglandinu u zvirat vedlo ke zvysenym pred a poimplantacnim ztratam a ke zvysene embryonalni/fetalni umrtnosti. Krome toho u zvirat, kterym byl podan inhibitor syntezy prostaglandinu v prubehu organogeneze, byla zaznamenana zvysena incidence ruznych malformaci, vcetne kardiovaskularnich. V prubehu prvniho a druhehotrimestru gravidity se meloxikam nema podavat, pokud to neni nevyhnutelne. V pripade lecby pacientky, ktera se snazi otehotnet, nebo pacientky behem prvniho nebo druheho trimestru gravidity je nutne podavat nizkou davku meloxikamu a lecba ma byt co nejkratsi.

V prubehu tretiho trimestru gravidity muze podavani vsech inhibitoru syntezy prostaglandinu vyvolat u plodu

kardiopulmonarni toxicitu (s predcasnym uzaverem arterialniho duktu a s plicni hypertenzi)

renalni dysfunkci, ktera se muze vyvinout do renalniho selhani s oligohydramniozou

u matky a novorozence, na konci gravidity

mozne prodlouzeni doby krvacivosti a antiagregacni ucinek, ktery se muze vyskytnout i pri malych davkach

inhibici kontrakci u matky, coz vede k oddalenemu nebo prodlouzenemu porodu.

V dusledku toho je meloxikam v prubehu tretiho trimestru gravidity kontraindikovan.

Kojeni I kdyz neexistuji konkretni zkusenosti s meloxikamem, je znamo, ze NSAID se vylucuji do materskeho mleka. Kojicim zenam se proto podavani meloxikamu z bezpecnostnich duvodu nedoporucuje.

Ucinky na schopnost ridit a obsluhovat stroje

Nebyly provedeny studie zabyvajici se ucinky meloxikamu na schopnost ridit a obsluhovat stroje. Podle farmakodynamickeho profilu a hlasenych nezadoucich reakci je vsak pravdepodobne, ze meloxikam nema zadny nebo pouze zanedbatelny vliv na vyse uvedene schopnosti. Pokud se vsak vyskytnou poruchy videni nebo ospalost, zavrate nebo jine poruchy centralni nervove soustavy, doporucuje se neridit a neobsluhovat stroje.

Nejcasteji pozorovane nezadouci ucinky jsou gastrointestinalni povahy. Mohou se vyskytnout pepticke vredy, perforace nebo krvaceni GI, ktere mohou byt nekdy fatalni, zejmena u starsich pacientu (viz bod 4.4). Po podani leku byly hlaseny nausea, zvraceni, prujem, flatulence, zacpa, dyspepsie, bolesti bricha, melena, hematemeze, ulcerozni stomatitida, exacerbace kolitidy a Crohnovy choroby (viz bod 4.4 Zvlastni upozorneni a zvlastni opatreni pro pouziti). Mene casto byla pozorovana gastritida.

Frekvence nezadoucich ucinku uvedenych nize, vychazeji z frekvence vyskytu nezadoucich ucinku hlasenych v klinickych studiich. Informace jsou zalozeny na klinickych studiich, zahrnujicich 3750

pacientu, kteri byli leceni dennimi peroralnimi davkami 7,5 nebo 15 mg meloxikamu v tabletach nebo tobolkach po dobu az 18 mesicu (prumerna delka lecby cinila 127 dnu).

Jsou uvedeny nezadouci ucinky leku, ktere se objevily ve zpravach obdrzenych v souvislosti s podavanim registrovaneho pripravku.

Nezadouci ucinky jsou rozdeleny podle frekvence jejich vyskytu takto:velmi caste (? 1/10); caste (? 1/100 a < 1/10); mene caste (? 1/1000 a < 1/100); vzacne (? 1/10.000 a < 1/1000); velmi vzacne (< 1/10,000).

b) Tabulka nezadoucich ucinku

Poruchy krevniho a lymfatickeho systemuCaste: anemie. Mene caste: abnormality krevniho obrazu: leukocytopenie, trombocytopenie, agranulocytoza (viz bod c).

Poruchy imunitniho systemuVzacne: anafylakticke/anafylaktoidni reakce.

Psychiatricke poruchyVzacne: zmeny nalady, nespavost a nocni mury.

Poruchy nervoveho systemuCaste: mirne zavrate, bolesti hlavy. Mene caste: silnejsi zavrate, huceni v usich, ospalost. Vzacne: zmatenost.

Poruchy okaVzacne: zrakove poruchy vcetne rozmazaneho videni.

Srdecni poruchy Mene caste: palpitace.

Cevni poruchyMene caste: zvyseny krevni tlak (viz bod 4.4), navaly.

Respiracni, hrudni a mediastinalni poruchyVzacne: astmaticke zachvaty u nekterych pacientu, alergickych na kyselinu acetylsalicylovou nebo NSAID.

Gastrointestinalni poruchyCaste: dyspepsie, nuceni na zvraceni, zvraceni, bolesti bricha, zacpa, nadymani, prujem. Mene caste: gastrointestinalni krvaceni, gastroduodenalni vredy, ezophagitida, stomatitida. Vzacne: gastrointestinalni perforace, gastritida, kolitida.

Pepticke vredy, perforace nebo gastrointestinalni krvaceni mohou byt zavazne zvlaste u starsich pacientu (viz bod 4.4).

Poruchy jater a zlucovych cestVzacne: hepatitida.

Poruchy kuze a podkozni tkaneCaste: pruritus, vyrazka. Mene caste: koprivka. Vzacne: angioedem, fotosenzitivni reakce.

Velmi vzacne: bulozni reakce, jako je Stevens-Johnsonuv syndrom a toxicka epidermalni nekrolyza.

Poruchy ledvin a mocovych cestMene caste: retence sodiku a vody, hyperkalemie (viz bod 4.4 a 4.5). Vzacne: akutni selhani ledvin u pacientu s rizikovymi faktory (viz bod 4.4).

Celkove poruchy a reakce v miste aplikaceCaste: edem vcetne edemu dolnich koncetin.

Vicenasobna vysetreniMene caste: prechodne zmeny u testu jaternich funkci (napr. zvysene hodnoty transaminaz nebo bilirubinu).Mene caste: patologicke laboratorni nalezy pri vysetreni funkce ledvin (napr. zvyseni kreatininu nebo mocoviny).

c) Informace charakterizujici individualni zavazne a/nebo casto se vyskytujici nezadouci reakce

Byly hlaseny izolovane pripady agranulocytozy u pacientu lecenych meloxikamem a jinymi potencialne myelotoxickymi lecivymi pripravky (viz bod 4.5).

d) Nezadouci ucinky, ktere zatim nebyly pozorovany v souvislosti s podavanim tohoto pripravku, ale ktere se obecne vyskytuji v souvislosti s podavanim jinych latek teto skupiny

Organicke poskozeni ledvin, jehoz dusledkem je pravdepodobne akutni renalni selhani: byly zaznamenany izolovane pripady intersticialni nefritidy, akutni tubularni nekrozy, nefrotickeho syndromu a papilarni nekrozy (viz bod 4.4).

V souvislosti s lecbou NSAID byly hlaseny edemy, hypertenze a srdecniho selhani. Udaje z klinickych a epidemiologickych studii ukazuji, ze pouzivani nekterych NSAID (zejmena ve vysokych davkach a pri dlouhodobe lecbe) muze byt spojeno s mirne vyssim rizikem arterialnich trombotickych prihod (napr. infarktu myokardu nebo cevni mozkove prihody) (viz bod 4.4).

Priznaky po akutnim predavkovani NSAID jsou obvykle omezeny na letargii, ospalost, nauseu, zvraceni a bolesti epigastria, ktere jsou pri podpurne lecbe obecne reverzibilni. Muze se objevit gastrointestinalni krvaceni. Tezka otrava muze vyvolat hypertenzi, akutni selhani ledvin, poruchy funkce jater, dechovy utlum, koma, krece, kardiovaskularni kolaps a srdecni zastavu. Anafylaktoidni reakce byly hlaseny pri terapeutickem uzivani NSAID a mohou se objevit po predavkovani. Pri predavkovani NSAID je nutno pacienty lecit symptomaticky a podpurne. V klinicke studii bylo demonstrovano urychlene odstraneni meloxikamu podavanim 4 g cholestyraminu trikrat denne.

Farmakoterapeuticka skupina: Nesteroidni protizanetliva a protirevmaticka leciva, oxikamy. ATC kod: M01AC06

Meloxikam je nesteroidni protizanetlive lecivo (NSAID) ze skupiny oxikamu s protizanetlivymi, analgetickymi a antipyretickymi vlastnostmi. Protizanetlive ucinky meloxikamu byly prokazany pomoci klasickych modelu zanetu. Stejne, jako u ostatnich NSAID, neni presny mechanizmus ucinku znam. Existuje ovsem alespon jeden

mechanizmus ucinku, spolecny vsem NSAID (vcetne meloxikamu), a to inhibice biosyntezy prostaglandinu, ktere jsou znamy jako mediatory zanetu.

AbsorpceMeloxikam se dobre absorbuje z gastrointestinalniho traktu, o cemz svedci vysoka absolutni biologicka dostupnost, ktera cini 89% po peroralnim podani (tobolka). Bylo prokazano, ze tablety, peroralni suspenze a tobolky jsou bioekvivalentni.

Po podani jednorazove davky je maximalni koncentrace v plazme dosazena za dve hodiny po podani suspenze a za 5-6 hodin po podani pevnych lekovych forem (tobolky a tablety). Po opakovanem podani bylo dosazeno ustaleneho stavu za 3-5 dni. Davkovani jednou denne vede k plazmatickym koncentracim meloxikamu s relativne malym kolisanim hranicnich koncentraci v rozsahu 0,4-1,0 µg/ml pri davkach 7,5 mg a 0,8-2,0 µg/ml pri davkach 15 mg (Cmin a Cmax v ustalenem stavu). Maximalni plazmaticke koncentrace meloxikamu v ustalenem stavu jsou dosazeny za 5-6 hodin po podani tablet, tobolek a peroralni suspenze. Dusledkem kontinualniho podavani po dobu delsi nez jeden rok mohou byt koncentrace podobne koncentracim dosazenym v pocatecnim ustalenem stavu. Rozsah absorpce meloxikamu po peroralnim podani neni ovlivnen soucasnym prijmem potravy.

Meloxikam se velmi silne vaze na plazmaticke bilkoviny, zejmena na albumin (99 %). Meloxikam pronika do synovialni tekutiny a dosahuje zde asi polovicnich koncentraci v porovnani s koncentraci v plazme. Distribucni objem je maly, v prumeru 11 litru. Interindividualni odchylky se pohybuji kolem 30-40%.

BiotransformaceMeloxikam prochazi rozsahlou biotransformaci v jatrech. V moci byly identifikovany ctyri ruzne metabolity meloxikamu, ktere jsou vsechny farmakodynamicky neaktivni. Hlavni metabolit 5'-karboxymeloxikam

hydroxymetylmeloxikamu, ktery je rovnez v mensi mire vylucovan (9% davky). Podle studii in vitro hraje v teto metabolicke premene dulezitou roli CYP 2C9, v mensi mire rovnez prispiva izoenzym CYP 3A4. Peroxidazova aktivita je u daneho pacienta pravdepodobne odpovedna za dalsi dva metabolity, ktere odpovidaji 16% a 4% podane davky.

Meloxikam je vylucovan prevazne ve forme metabolitu stejnym dilem do moci a stolice. Mene nez 5% denni davky se vylouci nezmeneno do stolice, zatimco do moci se vylouci pouze stopy vychozi slouceniny. Prumerny eliminacni polocas je priblizne 20 hodin. Celkova plazmaticka clearance je v prumeru priblizne 8 ml/min.

Pri terapeutickem davkovani 7,5 az 15 mg peroralne nebo intramuskularne ma meloxikam linearni farmakokinetiku.

Zvlastni populace Jaterni/ledvinova nedostatecnost Farmakokinetiku meloxikamu neovlivnuje podstatnym zpusobem ani jaterni, ani mirna nebo stredni ledvinova nedostatecnost. V terminalnim stadiu ledvinove nedostatecnosti muze zvyseni distribucniho objemu zpusobit vyssi koncentraci meloxikamu a proto se nesmi prekrocit davka 7,5 mg (viz bod 4.2).

Starsi pacienti Ve srovnani s mladsimi pacienty byla prumerna plazmaticka clearance u starsich pacientu v ustalenem stavu ponekud nizsi.

Predklinicke udaje vztahujici se k bezpecnosti

Preklinicke studie potvrdily, ze toxikologicky profil meloxikamu je identicky jako toxikologicky profil jinych NSAID: gastrointestinalni vredy a eroze, renalni papilarni nekroza pri vysokych davkach, podavanych dlouhodobe u dvou zivocisnych druhu.

Studie peroralni reprodukcni toxicity s podavanim meloxikamu potkanum prokazaly pokles poctu ovulaci, inhibici implantaci a embryotoxicke ucinky (zvyseni resorpce) pri davkach toxickych pro matky 1 mg/kg a vice. Studie reprodukcni toxicity u potkanu a kraliku nezjistily teratogenitu do peroralnich davek 4 mg/kg u potkanu a 80 mg/kg u kraliku.

Hladiny pouzivanych davek presahly klinickou davku (7,5 - 15 mg) 10x az 5x pri vyjadreni v mg/kg (osoba s telesnou hmotnosti 75 kg). Byly popsany fetotoxicke ucinky na konci tehotenstvi, zname v pripade vsech inhibitoru syntezy prostaglandinu. Znamky mutagenniho ucinku nebyly prokazany ani in vitro ani in vivo . U potkanu a mysi nebylo zjisteno nebezpeci karcinogenity pri davkach daleko prevysujicich davky klinicke.

Seznam pomocnych latek

Dihydrat natrium-citratu, monohydrat laktosy, mikrokrystalicka celulosa, krospovidon, koloidni bezvody oxid kremicity, magnesium-stearat.

Neuplatnuje se. 6.3

Zvlastni opatreni pro uchovavani

Tento lecivy pripravek nevyzaduje zadne zvlastni podminky uchovavani.

Druh obalu a velikost baleni

PVC/PVDC/Al blistry. Velikost baleni: 1, 2, 7, 10, 14, 15, 20, 28, 30, 50, 60, 100, 140, 280, 300, 500 nebo 1000 tablet. Na trhu nemusi byt vsechny velikosti baleni. 6.6

Navod k pouziti pripravku, zachazeni s nim

Zadne zvlastni pozadavky.

DRZITEL ROZHODNUTI O REGISTRACI

Actavis Group PTC ehf. Reykjavikurvegur 76-78220 Hafnarfjordur Island

DATUM PRVNI REGISTRACE/PRODLOUZENI REGISTRACE

Aciclovir - Anti Viral, Viralief

Common use Aciclovir is an antiviral drug, it is a synthetic ingredient with a similar molecular structure to purine nucleoside. Aciclovir is used to treat viral infections such as cold sores, to stop the growth of Herpes simplex virus, Varicella zoster virus (caused by chickenpox and shingles), Epstein Barr Virus (caused by glandular fever), and to a lesser extent Cytomegalovirus (CMV). It is also useful in preventing genital herpes and in preventing viral infections occurring in those with a lowered immune system. This medication may also help reduce the time when pain remains after the sores heal. In addition, in people with a weakened immune system, Aciclovir can decrease the risk of the virus spreading to other parts of the body and causing serious infections.

Dosage and direction

Take this medication by mouth with or without food, usually 2 to 5 times a day as directed by your doctor. Take this medicine by mouth with a glass of water. Take your medicine at regular intervals. Do not take your medicine more often than directed. Take all of your medicine as directed even if you think your are better. If you are using the liquid form of this medication, shake the bottle well before each dose. Carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose. Dosage is based on your medical condition and response to treatment. In children, dosage is also based on weight.

You should talk with your healthcare provider prior to taking Aciclovir if you have kidney disease, including kidney failure (renal failure), any allergies, including allergies to food, dyes, or preservatives. Let your healthcare provider know if you are pregnant or thinking of becoming pregnant, breastfeeding. Make sure to tell your healthcare provider about all medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. The medication passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug.

Aciclovir Injection is contraindicated for patients who develop hypersensitivity to Viralief or valaciclovir.

Possible side effects Side effects are potentially serious and you should report to your doctor or health care professional as soon as possible. These include, but are not limited to: allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue, chest pain, confusion, hallucinations, tremor, dark urine, increased sensitivity to the sun, redness, blistering, peeling or loosening of the skin (including inside the mouth), seizures, trouble passing urine or change in the amount of urine, unusual bleeding or bruising, or pinpoint red spots on the skin, unusually weak or tired, yellowing of the eyes or skin. Side effects that usually do not require medical attention: diarrhea, fever, headache, nausea, vomiting stomach upset. In this way report to your doctor or health care professional if they continue or are bothersome.

Drug interactions There are negative interactions that can occur when Aciclovir is combined with any of the drugs listed above. Phenytoin (Fosphenytoin) and Aciclovir: it may decrease the level of phenytoin in your blood, perhaps making it less effective. Your healthcare provider may need to measure the level of phenytoin in your blood (using a blood test) and adjust your dose as necessary. Probenecid can increase the level of Aciclovir in your blood, increasing your risk of acyclovir side effects. Your healthcare provider may need to decrease your acyclovir dosage to prevent this interaction from occurring. Acyclovir can increase the level of Tenofovir in your blood, potentially increasing your risk of side effects. Your healthcare provider may need to lower your tenofovir dosage to prevent drug interactions.

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include seizure (convulsions), hallucinations, and urinating less than usual or not at all.

Store at controlled room temperature of 15°C to 25°C (59°F to 77°F). Keep this medicine out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Calma - Definition Of Calma By The Free Dictionary, Calma

calmer

References in periodicals archive ?

In both Seinfeld and Calma. the Court acknowledged that a ratification defense would have been available if shareholders had been asked to approve a plan with "meaningful" limits, including "specific ceilings" based on the participant's specific position held and services performed.

Given that the topic at hand in Calma was compensation awarded to directors by directors, the case for self-interest was fairly easy for the plaintiffs to make.

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Spinning Wheels (cikrik) sendromu, koroner subklavyen calma sendromunun degisik bir formu olarak farkli anatomik gorunumlerde karsimiza cikabilir.

Calma - Heather Jensen and Edgar Calma. of Veneta, a daughter.

Specialist JanMichael Calma. Team Joint Base Lewis-McCord, Washington received best exhibit in show, culinary showpiece.

The unmet needs in Sindh are a tragedy waiting to happen," says Allan Calma. CWS-P/A's Deputy Director of the Disaster Management Program.

2 penalties ahead of Marina Kohncke, who is bidding to become Germany's first Badminton champion on Calma Schelly.

For the Australian context, chapters by Tom Calma and Marcia Langton situate Indigenous perspectives on communal land tenure within the broader policy setting.

Their portfolio of clients includes Roca Baaio, lighting companies such as Estiluz, Blauet and Metalarte and furniture firms such as Calma. Concepta and Arazzo.

Some are nationally prominent names such as Mick Dodson, Jackie Huggins, Warren Mundine, Larissa Behrendt and Tom Calma. while others are regionally and locally prominent.

Melbourne, Jan 15 (ANI): Aboriginal Social Justice Commissioner Tom Calma has said that there is "inherent racism" in Australia and that this attitude must change.

Doxylag Is A Treatment Of What - Answers On Healthtap, Doxylag

Eye to eye: It can help, when discussing it, to find things you mutually agree on that might benefit from consultation. Then approaching it curiously together, and perhaps offering to go with him, may be helpful. Also, there are some good websites that can help dispel certain myths about mental health treatment if that is applicable. Nami is good organization run by patients/"consumers" that provides info. . Read more

Community-Based: During the 1970s, there were multi-disciplinary community mental health centers established. These centers had therapists and groups and often offered occupational and recreational therapy to a broad range of individuals within their catchment area. On the other hand, there were far fewer options in terms of psychiatric medications than there are now. . Read more

R u on max meds. If you are on a maximal medical program such as nitrates. beta blockers and anti platelets and your already on the newer agent Ranexa then eecp is a nice option. If no other revascularization options are available such as angioplasty or bypass then( if a candidate qualifies) then transplant may be an option for refractory angina. . Read more

3 doctors agreed:

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PAWS: Post-acute withdrawal syndrome is persistent impairment that occurs after withdrawal from alcohol. opiates. benzos, antidepressants. & other substances. Full description is found by googling the phrase above. Good luck. . Read more

Tedral Advanced Patient Information, Tedol

Tedral (Oral)

Chemical Class: Methylxanthine

Uses For Tedral

Theophylline, ephedrine, and phenobarbital combination is used to treat the symptoms of bronchial asthma, asthmatic bronchitis, and other lung diseases. This medicine relieves cough, wheezing, shortness of breath, and troubled breathing. It works by opening up the bronchial tubes (air passages) of the lungs and increasing the flow of air through them.

Products containing theophylline, ephedrine, and phenobarbital were withdrawn from the U. S. market by Parke Davis in April, 1993.

Before Using Tedral

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Newborn infants may be especially sensitive to the effects of theophylline, ephedrine, and phenobarbital combination. This may increase the chance of side effects during treatment.

Geriatric

Patients older than 60 years of age may be especially sensitive to the effects of theophylline, ephedrine, and phenobarbital combination. This may increase the chance of side effects during treatment.

Pregnancy

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Artemether

Boceprevir

Cyclopropane

Halothane

Isocarboxazid

Lurasidone

Nifedipine

Praziquantel

Ranolazine

Rasagiline

Rilpivirine

Selegiline

Voriconazole

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Abiraterone Acetate

Acenocoumarol

Adinazolam

Alfentanil

Alprazolam

Amobarbital

Anileridine

Anisindione

Aprobarbital

Axitinib

Bortezomib

Bosutinib

Bromazepam

Brotizolam

Bupropion

Butabarbital

Butalbital

Cabazitaxel

Carisoprodol

Chloral Hydrate

Chlordiazepoxide

Chlorzoxazone

Cimetidine

Ciprofloxacin

Clobazam

Clonazepam

Clorazepate

Clorgyline

Cobicistat

Codeine

Crizotinib

Dantrolene

Dasatinib

Deferasirox

Delavirdine

Desogestrel

Diazepam

Dicumarol

Dienogest

Dronedarone

Drospirenone

Elvitegravir

Enoxacin

Enzalutamide

Erlotinib

Erythromycin

Estazolam

Estradiol Cypionate

Estradiol Valerate

Ethchlorvynol

Ethinyl Estradiol

Ethynodiol Diacetate

Etintidine

Etonogestrel

Etravirine

Everolimus

Fentanyl

Flunitrazepam

Flurazepam

Fluvoxamine

Furazolidone

Halazepam

Halothane

Hydrocodone

Hydromorphone

Idrocilamide

Ifosfamide

Imatinib

Imipenem

Iproniazid

Irinotecan

Ivacaftor

Ixabepilone

Ketazolam

Ketorolac

Lapatinib

Levofloxacin

Levonorgestrel

Levorphanol

Linagliptin

Lopinavir

Lorazepam

Lormetazepam

Maraviroc

Medazepam

Medroxyprogesterone Acetate

Meperidine

Mephenesin

Mephobarbital

Meprobamate

Mestranol

Metaxalone

Methocarbamol

Methohexital

Methoxyflurane

Mexiletine

Midazolam

Midodrine

Mifepristone

Morphine

Morphine Sulfate Liposome

Naproxen

Nialamide

Nilotinib

Nimodipine

Nitrazepam

Nordazepam

Norelgestromin

Norethindrone

Norgestimate

Norgestrel

Oxazepam

Oxycodone

Oxymorphone

Pargyline

Pefloxacin

Peginterferon Alfa-2a

Pentobarbital

Phenelzine

Phenindione

Phenobarbital

Phenprocoumon

Prazepam

Primidone

Procarbazine

Propoxyphene

Quazepam

Quetiapine

Remifentanil

Rivaroxaban

Rofecoxib

Roflumilast

Romidepsin

Secobarbital

Sirolimus

Sodium Oxybate

Sufentanil

Sunitinib

Tacrolimus

Tapentadol

Temazepam

Temsirolimus

Teniposide

Thiabendazole

Thiopental

Ticagrelor

Tolvaptan

Tranylcypromine

Triazolam

Troleandomycin

Vandetanib

Vemurafenib

Vincristine Sulfate

Vincristine Sulfate Liposome

Zileuton

Zolpidem

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Adenosine

Adinazolam

Alprazolam

Aminoglutethimide

Amiodarone

Amprenavir

Azithromycin

Betamethasone

Bexarotene

Bromazepam

Brotizolam

Cannabis

Carbamazepine

Chlordiazepoxide

Chlorpromazine

Clobazam

Clonazepam

Clorazepate

Clozapine

Cortisone

Desogestrel

Dexamethasone

Diazepam

Dienogest

Digitoxin

Disulfiram

Drospirenone

Estazolam

Estradiol Cypionate

Estradiol Valerate

Ethinyl Estradiol

Ethosuximide

Ethynodiol Diacetate

Etonogestrel

Febuxostat

Felodipine

Flunitrazepam

Flurazepam

Fosphenytoin

Ginkgo

Granisetron

Griseofulvin

Halazepam

Interferon Alfa-2a

Ipriflavone

Isoproterenol

Itraconazole

Ketazolam

Lamotrigine

Leucovorin

Levomethadyl

Levonorgestrel

Lorazepam

Lormetazepam

Medazepam

Medroxyprogesterone Acetate

Mestranol

Methotrexate

Methylprednisolone

Metoprolol

Midazolam

Nilutamide

Nitrazepam

Norelgestromin

Norethindrone

Norgestimate

Norgestrel

Oxazepam

Oxcarbazepine

Pancuronium

Pentoxifylline

Phenobarbital

Phenytoin

Piperine

Prazepam

Prednisone

Propafenone

Quazepam

Quinidine

Quinine

Rifampin

Rifapentine

Riluzole

Risperidone

Ritonavir

Rufinamide

Secobarbital

St John's Wort

Tacrine

Tacrolimus

Telithromycin

Temazepam

Theophylline

Thioridazine

Tiagabine

Ticlopidine

Tipranavir

Topiramate

Triazolam

Valproic Acid

Verapamil

Viloxazine

Warfarin

Zafirlukast

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

Angle-closure glaucoma or

Convulsions (seizures) or

Heart or blood vessel disease or

High blood pressure or

Underactive adrenal gland—May make these conditions worse.

Diabetes mellitus—Phenobarbital may make the condition worse; your doctor may need to change the dose of your diabetes medicine.

History of drug abuse or

Liver disease—The effects of phenobarbital or theophylline may be increased.

Kidney disease—The effects of phenobarbital may be increased.

Pain—Phenobarbital may cause unusual excitement in the presence of pain.

Proper Use of Tedral

This medicine works best when taken with a glass of water on an empty stomach (either 30 minutes to 1 hour before meals or 2 hours after meals) since that way it will get into the blood sooner. However, in some cases your doctor may want you to take this medicine with meals or right after meals to lessen stomach upset. If you have any questions about how you should be taking this medicine, check with your doctor.

Take this medicine only as directed. Do not take more of it and do not take it more often than recommended on the label, unless otherwise directed by your doctor. To do so may increase the chance of serious side effects. Also, if too much is taken, the phenobarbital in this medicine may become habit-forming.

In order for this medicine to help your medical problem, it must be taken every day in regularly spaced doses as recommended. This is necessary to keep a constant amount of this medicine in the blood. To help keep the amount constant, do not miss any doses.

Make certain your health care professional knows if you are on any special diet, such as a high-protein, low-carbohydrate or low-protein, high-carbohydrate diet.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For bronchial asthma, asthmatic bronchitis, and other lung diseases:

For oral dosage form (tablets):

Adults—1 or 2 tablets every 4 hours.

Children weighing more than 27 kilograms (kg)—1/2 or 1 tablet every 4 hours.

Children weighing less than 27 kg—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using Tedral

The theophylline in this medicine may add to the central nervous system stimulant effects of caffeine-containing foods or beverages such as chocolate, cocoa, tea, coffee, and cola drinks. Avoid eating or drinking large amounts of these foods or beverages while taking this medicine. If you have any questions about this, check with your doctor.

The phenobarbital in this medicine will add to the effects of alcohol and other CNS depressants (medicines that slow down the nervous system, possibly causing drowsiness). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; other barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are using this medicine.

A change in your usual behavior or physical well-being may affect the way this medicine works in your body. Check with your doctor if you:

have a fever of 102 °F or higher for at least 24 hours or higher than 100 °F for longer than 24 hours.

start or stop smoking.

start or stop taking another medicine.

change your diet for a long time.

Before you have myocardial perfusion studies (a medical test that shows how well blood is flowing to your heart), tell the medical doctor in charge that you are taking this medicine. The results of the test may be affected by this medicine.

This medicine may cause some people to become dizzy, lightheaded, drowsy, or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert.

Tedral Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Less common or rare

Heartburn and/or vomiting

Symptoms of toxicity

Abdominal pain, continuing or severe

confusion or change in behavior

convulsions (seizures)

dark or bloody vomit

diarrhea

dizziness or lightheadedness

fast and/or irregular heartbeat, continuing

nervousness or restlessness, continuing

trembling, continuing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Chest discomfort or pain

drowsiness

fast heartbeat

headache

muscle cramps

nausea

nervousness or restlessness

trembling

trouble in sleeping

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Truven Health Micromedex products as delivered by Drugs. com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs. com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products.

Copyright 2016 Truven Health Analytics, Inc. All Rights Reserved.

Visthesia - Soluciones Viscoelasticas - Catarata - Medical Technology, Visthesia

VISTHESIA

VISTHESIA® es el primer y unico OVD que combina un viscoelastico oftalmico con anestesia auxiliar, lo que proporciona mayor comodidad para los pacientes, sobre todo en procedimientos prolongados.

La lidocaina auxiliar garantiza la comodidad del paciente al inicio de la cirugia

La aplicacion topica preoperatoria con hialuronato sodico

cubre e hidrata las celulas epiteliales para una vision intraocular clara

minimiza la necesidad de hidratacion adicional durante la cirugia

VISTHESIA OVD cohesivo intracameral

Mantiene el espacio en la camara anterior

Proporciona proteccion endotelial 1 y mantiene la dilatacion de la pupila 2 para casos de cataratas rutinarios o complejos

Ademas, garantiza una dispersion uniforme de la lidocaina a traves del ojo hacia todos los tejidos

La liberacion precisa de lidocaina al 1 % combinada en un solo paso ahorra tiempo y la preparacion de un anestesico intracameral por separado

VISTHESIA – “Disenado para la sencillez”

VISTHESIA 1,0 % y VISTHESIA 1,5 % no se vende en el Reino Unido ni en Portugal.

VISTHESIA: el OVD que alivia el dolor

VISTHESIA incluye una solucion topica y otra intracameral en un mismo envase. VISTHESIA topico para la proteccion e hidratacion de la cornea contiene un 0,3 % de hialuronato sodico y un 2,0 % de clorhidrato de lidocaina. VISTHESIA intracameral se encuentra disponible con dos concentraciones de hialuronato sodico: 1,5 % y 1,0 %, ambas asociadas a un 1,0 % de clorhidrato de lidocaina.

Lipitor - Cholesterol Lowering, Dislipat

Common use Atorvastatin is a cholesterol-lowering used to treat high cholesterol or to lower the risk of stroke, heart attack or other heart complications in patients with coronary heart disease or second type of diabetes. Atorvastatin helps to clear harmful low-density lipoprotein cholesterol out of the blood and by limiting the body's ability to form new LDL cholesterol. Thus it can help prevent hardening of the arteries and heart disease, conditions that can lead to vascular disease, heart attack, stroke.

Dosage and direction Take it orally once a day with or without food. Atorvastatine should be taken with full glass of water. The common dose for adults is 10 mg once daily. The common dose for children from 10 to 17 years of age is 10 mg once daily. Using Atorvastatin in children less than 10 years of age is not recommended and dose must be determined by your family doctor.

Note: this instruction presented here just for review. It's very necessary to consult with your doctor before using. It help you to get best results.

Precautions People with diabetes, underactive thyroid glands, kidney disease, or muscle disease sometimes need additional tests before or during atorvastatin therapy since dosage adjustments may be required. Do not use large amounts of alcohol while taking this drug because it can worsen the adverse effects of this medicine on the liver. Atorvastatin should not be used during pregnancy, becoming pregnant or lactating without doctor's advice. Do not use Atorvastatin before breast-feeding without doctor's permission.

Contraindications Atorvastatin is not allowed to people who have liver problems or unexplained abnormal liver function tests. Do not use it if you are taking an HIV protease inhibitor (eg, ritonavir), itraconazole, or mibefradil. Also Atorvastatin contraindicated if you are hypersensitive to any components of this medication, pregnancy or breast-feeding.

Possible side effect They may include all types of an allergic reaction. Also the most possible side effects include: muscle pain, tenderness, or weakness with fever or flu symptoms; or nausea, clay-colored stools, stomach pain, low fever, jaundice, loss of appetite, dark urine. Less serious include: mild nausea or stomach pain, stomach upset, heartburn; constipation, bloating, gas; stuffy nose; itching, skin rash; headache. If you experience one of them stop using Atorvastatin and tell your doctor as soon as possible. Also consult with your doctor about any side effect that seems unusual.

Drug interaction Atrovastatin interact with the following drugs: digoxin; erythromycin or clarithromycin; gemfibrozil or fenofibrate; niacin; an antifungal medication such as itraconazole, fluconazole, or ketoconazole; drugs that weaken your immune system such as cancer medicine or steroids, cyclosporine, sirolimus, tacrolimus, and others; HIV or AIDS medication such as indinavir, nelfinavir, ritonavir, lopinavir-ritonavir, or saquinavir. Also note that interaction between two medications does not always mean that you must stop taking one of them. As usual it affects the the effect of drugs, so consult with your doctor about how it interactions are being managed or should be managed.

If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not increase your recommended dose. Take your usually dose next day in the same regularly time.

Symptoms of Atorvastatin are not known well but most possible of them include a severe drop in blood pressure and a faster heartbeat. If you experience one of them or any unusual symptoms, call your doctor immediately.

Store at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture, kids and pets. Do not use after expiration term.

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Common use Atorvastatin is a cholesterol-lowering used to treat high cholesterol or to lower the risk of stroke, heart attack or other heart complications in patients with coronary heart disease or second type of diabetes. Atorvastatin helps to clear harmful low-density lipoprotein cholesterol out of the blood and by limiting the body's ability to form new LDL cholesterol. Thus it can help prevent hardening of the arteries and heart disease, conditions that can lead to vascular disease, heart attack, stroke.

Dosage and direction Take it orally once a day with or without food. Atorvastatine should be taken with full glass of water. The common dose for adults is 10 mg once daily. The common dose for children from 10 to 17 years of age is 10 mg once daily. Using Atorvastatin in children less than 10 years of age is not recommended and dose must be determined by your family doctor.

Note: this instruction presented here just for review. It's very necessary to consult with your doctor before using. It help you to get best results.

Precautions People with diabetes, underactive thyroid glands, kidney disease, or muscle disease sometimes need additional tests before or during atorvastatin therapy since dosage adjustments may be required. Do not use large amounts of alcohol while taking this drug because it can worsen the adverse effects of this medicine on the liver. Atorvastatin should not be used during pregnancy, becoming pregnant or lactating without doctor's advice. Do not use Atorvastatin before breast-feeding without doctor's permission.

Contraindications Atorvastatin is not allowed to people who have liver problems or unexplained abnormal liver function tests. Do not use it if you are taking an HIV protease inhibitor (eg, ritonavir), itraconazole, or mibefradil. Also Atorvastatin contraindicated if you are hypersensitive to any components of this medication, pregnancy or breast-feeding.

Possible side effect They may include all types of an allergic reaction. Also the most possible side effects include: muscle pain, tenderness, or weakness with fever or flu symptoms; or nausea, clay-colored stools, stomach pain, low fever, jaundice, loss of appetite, dark urine. Less serious include: mild nausea or stomach pain, stomach upset, heartburn; constipation, bloating, gas; stuffy nose; itching, skin rash; headache. If you experience one of them stop using Atorvastatin and tell your doctor as soon as possible. Also consult with your doctor about any side effect that seems unusual.

Drug interaction Atrovastatin interact with the following drugs: digoxin; erythromycin or clarithromycin; gemfibrozil or fenofibrate; niacin; an antifungal medication such as itraconazole, fluconazole, or ketoconazole; drugs that weaken your immune system such as cancer medicine or steroids, cyclosporine, sirolimus, tacrolimus, and others; HIV or AIDS medication such as indinavir, nelfinavir, ritonavir, lopinavir-ritonavir, or saquinavir. Also note that interaction between two medications does not always mean that you must stop taking one of them. As usual it affects the the effect of drugs, so consult with your doctor about how it interactions are being managed or should be managed.

If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not increase your recommended dose. Take your usually dose next day in the same regularly time.

Symptoms of Atorvastatin are not known well but most possible of them include a severe drop in blood pressure and a faster heartbeat. If you experience one of them or any unusual symptoms, call your doctor immediately.

Store at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture, kids and pets. Do not use after expiration term.

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Common use Atorvastatin is a cholesterol-lowering used to treat high cholesterol or to lower the risk of stroke, heart attack or other heart complications in patients with coronary heart disease or second type of diabetes. Atorvastatin helps to clear harmful low-density lipoprotein cholesterol out of the blood and by limiting the body's ability to form new LDL cholesterol. Thus it can help prevent hardening of the arteries and heart disease, conditions that can lead to vascular disease, heart attack, stroke.

Dosage and direction Take it orally once a day with or without food. Atorvastatine should be taken with full glass of water. The common dose for adults is 10 mg once daily. The common dose for children from 10 to 17 years of age is 10 mg once daily. Using Atorvastatin in children less than 10 years of age is not recommended and dose must be determined by your family doctor.

Note: this instruction presented here just for review. It's very necessary to consult with your doctor before using. It help you to get best results.

Precautions People with diabetes, underactive thyroid glands, kidney disease, or muscle disease sometimes need additional tests before or during atorvastatin therapy since dosage adjustments may be required. Do not use large amounts of alcohol while taking this drug because it can worsen the adverse effects of this medicine on the liver. Atorvastatin should not be used during pregnancy, becoming pregnant or lactating without doctor's advice. Do not use Atorvastatin before breast-feeding without doctor's permission.

Contraindications Atorvastatin is not allowed to people who have liver problems or unexplained abnormal liver function tests. Do not use it if you are taking an HIV protease inhibitor (eg, ritonavir), itraconazole, or mibefradil. Also Atorvastatin contraindicated if you are hypersensitive to any components of this medication, pregnancy or breast-feeding.

Possible side effect They may include all types of an allergic reaction. Also the most possible side effects include: muscle pain, tenderness, or weakness with fever or flu symptoms; or nausea, clay-colored stools, stomach pain, low fever, jaundice, loss of appetite, dark urine. Less serious include: mild nausea or stomach pain, stomach upset, heartburn; constipation, bloating, gas; stuffy nose; itching, skin rash; headache. If you experience one of them stop using Atorvastatin and tell your doctor as soon as possible. Also consult with your doctor about any side effect that seems unusual.

Drug interaction Atrovastatin interact with the following drugs: digoxin; erythromycin or clarithromycin; gemfibrozil or fenofibrate; niacin; an antifungal medication such as itraconazole, fluconazole, or ketoconazole; drugs that weaken your immune system such as cancer medicine or steroids, cyclosporine, sirolimus, tacrolimus, and others; HIV or AIDS medication such as indinavir, nelfinavir, ritonavir, lopinavir-ritonavir, or saquinavir. Also note that interaction between two medications does not always mean that you must stop taking one of them. As usual it affects the the effect of drugs, so consult with your doctor about how it interactions are being managed or should be managed.

If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not increase your recommended dose. Take your usually dose next day in the same regularly time.

Symptoms of Atorvastatin are not known well but most possible of them include a severe drop in blood pressure and a faster heartbeat. If you experience one of them or any unusual symptoms, call your doctor immediately.

Store at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture, kids and pets. Do not use after expiration term.

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Categor, Categor

category

noun. plural categories.

Metaphysics.

(in Aristotelian philosophy) any of the fundamental modes of existence, such as substance, quality, and quantity, as determined by analysis of the different possible kinds of predication.

(in Kantian philosophy) any of the fundamental principles of the understanding, as the principle of causation.

any classification of terms that is ultimate and not susceptible to further analysis.

categories, Also called Guggenheim. ( used with a singular verb ) a game in which a key word and a list of categories, as dogs, automobiles, or rivers, are selected, and in which each player writes down a word in each category that begins with each of the letters of the key word, the player writing down the most words within a time limit being declared the winner.

Mathematics. a type of mathematical object, as a set, group, or metric space, together with a set of mappings from such an object to other objects of the same type.

Hyaluron Hexal Zakazat Lekarstva Iz Germanii, Poisk Lekarstva Germaniya, Kupit Lekarstva, Poisk Leka

Поиск лекарства Германия по немецкой аптечной базе

Как правильно работать с поиском:

1. В строку поиска необходимо вписывать название лекарств медикаментов латинскими буквами или номер ( PZN ) например: 78597. 2. Если лекарство медикамент который Вы ищите искал кто то до вас то наша система поиска автоматически предложит Вам различные варианты. которые Вы можете выбрать из появившегося списка. 3. Так же для более удобного поиска Вы можете пользоваться "сортировкой" по названию . цене и производителю медикамента который Вы ищите.

Если Вы ничего не нашли отправьте нам свой запрос через форму заказа лекарства .

Beta Micoter, Betamethasone Dipropionate, Clotrimazole, Beta-Micoter

Beta Micoter

Feedback - Please use the form below to send your query or comment

You must sign in to use this servcie

Not to be used in * Acne vulgaris * Allergy to this medicine or similar medicines * Bacterial skin infections * Children under 12 years of age * Chronic inflammatory disorder of the facial skin (acne rosacea) * Inflammatory rash around the mouth (perioral dermatitis) * Nappy rash * Viral skin infections such as chickenpox or herpes simplex

* Rash * Skin darkening * Stinging and redness * Blistering * Excessive fluid retention in the body tissues, resulting in swelling (oedema) * Burning sensation * Excessive hair growth (hypertrichosis) * Skin thinning * Secondary infection * Inflammation of the hair follicles (folliculitis)

* You should not cover the area being treated with airtight dressings such as bandages or other dressings, including nappies, as these will enhance the absorption of the medicine into the body and may increase the risk of adverse effects. * Avoid contact of this medicine with the eyes. * In pregnancy, this medicine should not be applied extensively in large amounts, or for prolonged periods. * Continuous, long term use of this medicine should be avoided in children. * If skin irritation occurs, or an infection is not resolved, seek medical advice. * Long term use of this medicine on large areas of skin, particularly in skin folds or if the skin is damaged, may result in increased absorption of the medicine into the bloodstream, with an increased risk of side effects. * This medicine should not be used for longer than five days on the face or in children.

SOLUTION FOR INJECTION

Remena, Remena

Renewable Energy and Water Desalination are a Moral Commitment for the Prosperity of our Children and Grandchildren. we shall leave a Clean and Healthy Planet for them

?????? ?????? ?????? ????????? "??????" ???? ?? ?? ??????? ??????? ??????? ????? ?????

????? ?? ????? ?? ??? ??? ?????? ???? ??? ? ??? ??????

The REMENA team announces with sadness that the founder and promoter of the Master's Cours REMENA has passed

Renewable Energy and Energy Efficiency for the MENA Region an Intercultural Master's Programme for Young Professionals Click here

in collaboration between

Cairo University The University of University of

Faculty of Engineering Kassel Monastir

View Accreditation Certificates AR ASIIN

Over 35 Master's Theses published Click to download -------------------

3rd Group with Advisory Board at the Faculty of Engineering, Cairo University 30 Oct. 2011 Higher Resolution

Students of the second Group 2010 (full resolution)

REMENA Students in Kuraymat, Egypt 12 Oct. 2010

On 11 October 2009 start of the first course was celebrated in Cairo Students of the first Group 2009

For more information e-mail to: [email protected] de

see also the film MARHABA AFRICA to get an impression of the Cairo University

Aprinol - Buy Aprinol 180 Caps - Eca Stack, Aprinol

Aprinol 180 Caps by Klein Becker

Aprinol helps Men and Women lose those love handles! A solution for Upper Body (Apple-Shaped) Adiposity. Upper Body Adiposity (UBA) -- the "apple-shaped" condition characterized by the accumulation of unwanted, embarrassing adipose (fat) tissue in the center and upper parts of the body, primarily in the abdominal area, waist, upper arms, chest, and back. It's undeniable, unpleasant, and if you've been trying to rid yourself of UBA without much success, you already know it takes much more than some ordinary diet pill to defeat upper body fat accumulation. It takes Aprinol, the first weight-control compound specifically designed to reduce the resistant, large-cell "depot fat" that makes UBA so difficult to manage.

Aprinol is known all over the World as the "Granddaddy of all Fat-burners." The Aprinol is so effective in burning excess body fat without diet or exercise, it's become the most imitated fat loss product on the market. But the truth is there is only one, real Aprinol. Original Aprinol is protected by U. S. Patent, and clinically proven to eliminate excess body fat. The Patented Aprinol helps to get rid of figure-destroying fat without diet or exercise! Of course, regular exercise and a healthy diet is always a good thing.

Here are the benefits to using Aprinol :

Lose body fat 24 hours a day

Improved energy and endurance

Aprinol increases the body's metabolism

Enhances concentration and alertness

Aprinol is an ECA Stack that contains Ephedrine formula, Aspirin and Caffeine.

Aprinol Supplement Facts

Servings Per Container:

Amount Per Serving

Herbal ephedra formula Alkaloids

Aprinol Directions

Take 2 Aprinol caps with a full glass of water, three times per day. Do not exceed 6 caps daily.

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Ketotilon, Ketotilon

Why register with MediGuard?

We are a free monitoring service designed for patients like you who want to be in the driver seat of your medical treatment. We have a community of more than 2.6 million members and offer the services below.

Medication Information Personalized Risk Rating Easy to understand overview Serious Side Effects Printable Medication List

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Health condition information Easy to understand overview Commonly Used Medications

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Research participation Option to participate in medical surveys & studies*

Ketotifen (Ketotifen)

What is your Risk Rating for this medicine?

The risk of serious side effects for taking this medicine can be different if you take other medicines or if you suffer from a condition. Get your Risk Rating by creating a profile in a few steps.

Benefits:

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You can create profiles for you and your loved ones.

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Share your story! Tell us how MediGuard has helped you or someone you love. Download the MediGuard Mobile App to manage your prescription and over-the-counter medications, for free. Taking multiple medications puts you at risk for possible drug-drug interactions Monitor the medical treatment of you and your loved ones.

DISCLAIMER: MediGuard is not intended to be a substitute for professional medical advice. MediGuard cannot and does not take into consideration every possible interaction or account for individual responses to medicine. Different individuals may respond to medication in different ways. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective, or appropriate for any given patient. Always seek the advice of a qualified health provider with any questions you may have before making any changes to your treatment. The use of the MediGuard site and its content is at your own risk. The MediGuard site and the information contained in it is intended for users in the United States and information in other countries may be different.

© Quintiles 2016

Beclazone (Discontinued In The Uk - March 2010), Beclazone

Beclazone (discontinued in the UK - March 2010)

What is it used for?

How does it work?

Beclazone inhalers and Beclazone easi-breathe inhalers contain the active ingredient beclometasone dipropionate (previously spelt beclomethasone in the UK), which is a type of medicine known as a corticosteroid. (NB. Beclometasone inhalers are also available without a brand name, ie as the generic medicine.)

Corticosteroids are hormones that are produced naturally by the adrenal glands. They have many important functions, including control of inflammatory responses. Beclometasone is a synthetic corticosteroid and is used to decrease inflammation in the lungs. (NB. Corticosteroids are often simply called steroids, but it should be noted that they are very different from another group of steroids, called anabolic steroids, which have gained notoriety because of their abuse by some athletes and body builders.)

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When beclometasone is inhaled into the lungs it is absorbed into the cells of the lungs and airways. Here it works by preventing the release of certain chemicals from the cells. These chemicals are important in the immune system and are normally involved in producing immune and allergic responses that result in inflammation. By decreasing the release of these chemicals in the lungs and airways, inflammation is reduced.

In asthma, the airways tighten due to inflammation and can also be blocked by mucus. This makes it difficult for air to get in and out of the lungs. By preventing the inflammation and excess mucus formation, beclometasone makes it easier to breathe and helps prevent asthma attacks.

Beclometasone is taken using an inhaler device to treat asthma. Inhaling the medicine allows it to act directly in the lungs where it is needed most. It also reduces the potential for side effects occurring in other parts of the body, as the amount absorbed into the blood through the lungs is lower than if it is taken by mouth.

Beclometasone taken by inhaler is known as a preventer. This is because it is taken regularly to reduce the inflammation in the lungs and prevent asthma attacks. Symptoms usually start to get better between three to seven days after starting treatment. However, it is important to continue using this medicine regularly, even after your asthma symptoms have improved, in order to prevent them coming back.

Warning!

This medicine is known as a preventer and it should be taken regularly to prevent asthma attacks. It should not be used to relieve an asthma attack, as it will not work for this purpose. An asthma attack needs to be treated with a medicine that quickly opens the airways, such as salbutamol or terbutaline. These are known as relievers, and you should make sure you carry your reliever inhaler with you at all times to relieve an asthma attack if it happens. Consult your doctor if you need to use your reliever more frequently than normal, or if it becomes less effective at treating attacks, as this may indicate that your asthma is getting worse and your doctor may need to prescribe you another medicine.

Do not exceed the dose of this medicine that your doctor has prescribed for you.

You should not suddenly stop taking this medicine unless your doctor tells you otherwise, as your asthma symptoms are likely to return.

Inhalers may cause an unexpected increase in wheezing and difficulty breathing (paradoxical bronchospasm) straight after using them. If this happens, don't use the inhaler again, use your reliever inhaler to open your airways and consult your doctor immediately.

Inhaled corticosteroids can sometimes cause a fungal infection in the mouth called oral thrush. To minimise the chances of this you should rinse your mouth with water or clean your teeth after inhaling each dose. Using a spacer device can also help avoid this problem.

Inhaled corticosteroids have considerably fewer side effects than steroids taken by mouth. However, when taken for long periods of time at high doses, inhaled steroids do have the potential to cause side effects such as glaucoma. cataracts. thinning of the bones (osteoporosis ), slowed growth in children and adolescents, and to suppress the functioning of the adrenal glands (glands that produce natural steroid hormones). For this reason your doctor will prescribe the lowest effective dose to control your symptoms, and monitor for these side effects. Do not exceed the dose of this medicine that your doctor has prescribed for you. It is recommended that children receiving long-term treatment with corticosteroids have their growth monitored. If a child's growth appears to be slowed your doctor may refer them to a paediatrician. For further information talk to your doctor or pharmacist.

People with severe asthma should have regular blood tests to monitor the amount of potassium in their blood. This is because low oxygen levels in the blood (hypoxia) and various asthma medicines can lower blood potassium levels.

Use with caution in

Not to be used in

Known sensitivity or allergy to any ingredient.

Beclazone 250 microgram strength inhalers are not recommended for children.

This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.

If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

Pregnancy and Breastfeeding

Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

This medicine should be used with caution during pregnancy. However, it is important that asthma is well controlled in pregnant women. Wherever possible, asthma medications should be taken by inhaler, as this minimises the amount of medicine that enters the bloodstream and crosses the placenta to the baby. Seek medical advice from your doctor.

In general, the amount of corticosteroid that passes into the breast milk after using an inhaler is negligable and probably too small to be harmful to the baby. However, you should seek medical advice from your doctor before breastfeeding while using this medicine.

Label warnings

Do not stop taking this medication except on your doctor's advice.

Follow the printed instructions you have been given with this medication.

Side effects

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.

Yeast infection of the mouth (oral thrush)

Throat irritation

Hoarseness

Cough (if this inhaler makes you cough, using your reliever inhaler before using this one may help)

Unexpected narrowing of the airways (paradoxical bronchospasm)

Systemic effects (eg, Cushing's syndrome, adrenal suppression, slowed growth in children and adolescents, decreased bone mineral density, cataract and glaucoma) may occur after high doses for prolonged periods - see warning above.

The side effects listed above may not include all of the side effects reported by the drug's manufacturer.

For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

How can this medicine affect other medicines?

Tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to ensure that the combination is safe .

Beclometasone may potentially decrease the amount of potassium in the blood. If it is taken in combination with any of the following medicines, which can also lower potassium in the blood, the risk of a low blood potassium level (hypokalaemia) is increased:

xanthine derivates, such as theophylline or aminophylline

oral corticosteroids, such as prednisolone

beta 2 agonists, such as salbutamol, salmeterol

diuretics, such as bendroflumethiazide and furosemide.

A low blood potassium level can have serious effects, which is why people with severe asthma, who may be taking several of these medicines, should have their blood potassium level monitored regularly.

Other medicines containing the same active ingredient

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Zex™ Pro Safety Blow-Down Kit, Zitrofar

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Pro Safety Blow Down Kit (Fits ALL Valves)

Instructions

PRO SAFETY BLOW DOWN KIT, ZEX

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Details

Racetracks require your nitrous bottle to be vented to the outside of your race car; Do it with the ultimate in function & show stopping good looks

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Antibiotics Buy Doxycycline At, Doxyveto

Antibiotics

Doxycycline (Doxyveto)

Doxycycline is used for treating infections caused by certain bacteria. It may be used in combination with other medicines to treat certain amoeba infections. It may also be used to prevent or slow the progression of anthrax after exposure. Doxycycline is a tetracycline antibiotic. It works by slowing the growth of bacteria. Slowing bacteria's growth allows the body's immune system to destroy the bacteria.

Take Doxycycline exactly as it was prescribed for you.

Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Take Doxycycline with a full glass of water (8 ounces).

Do not take the medication with milk or other dairy products, unless your doctor has told you to. Dairy products can make it harder for your body to absorb the medicine.

Do not crush, break, or open a capsule. Swallow the pill whole. It is specially made to release medicine slowly in the body. Breaking or opening the pill would cause too much of the drug to be released at one time.

Take Doxycycline for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated.

Doxycycline will not treat a viral infection such as the common cold or flu.

Do not give this medicine to another person, even if they have the same condition you have.

If you need to have any type of surgery, tell the surgeon ahead of time that you are taking Doxycycline. You may need to stop using the medicine for a short time.

Do not take any Doxycycline after the expiration date printed on the label. Using expired Doxycycline can cause damage to your kidneys.

Do not give Doxycycline to a child younger 8 years. It can cause permanent yellowing or graying of the teeth, and it can affect a child's growth.

If you miss a dose of Doxycycline, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Doxycycline.

Store Doxycycline at room temperature between 68 and 77 degrees F (20 and 25 degrees C) in a tightly closed container. Brief periods at temperatures of 59 to 86 degrees F (15 to 30 degrees C) are permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Doxycycline out of the reach of children and away from pets.

Do NOT use Doxycycline if:

you are allergic to any ingredient in Doxycycline, or to similar medicines such as demeclocycline (Declomycin), minocycline (Dynacin, Minocin, Solodyn, Vectrin), or tetracycline (Brodspec, Panmycin, Sumycin, Tetracap)

you are taking acitretin, isotretinoin, or a penicillin (eg, amoxicillin)

you have recently received or will be receiving a live oral typhoid vaccine.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Doxycycline. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have diarrhea, a stomach or intestinal infection, a history of lupus, or the blood disease porphyria

if you have liver or kidney disease, you may need a dose adjustment or special tests to safely take Doxycycline.

Some medicines may interact with Doxycycline. Tell your health care provider if you are taking any other medicines, especially any of the following:

Barbiturates (eg, phenobarbital), carbamazepine, or hydantoins (eg, phenytoin) because they may decrease Doxycycline's effectiveness

Acitretin or isotretinoin because side effects, such as increased pressure inside the skull (resulting in severe headaches and vision problems) may occur

Anticoagulants (eg, warfarin), digoxin, methotrexate, or methoxyflurane because the risk of their side effects may be increased by Doxycycline

Live oral typhoid vaccine, hormonal birth control (eg, birth control pills), or penicillins (eg, amoxicillin) because their effectiveness may be decreased by Doxycycline.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Doxycycline may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Be sure to use Doxycycline for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.

Long-term or repeated use of Doxycycline may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.

Mild diarrhea is common with antibiotic use. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or blood stools occur. Do not treat diarrhea without first checking with your doctor.

Doxycycline may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Doxycycline. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.

Tell your doctor or dentist that you take Doxycycline before you receive any medical or dental care, emergency care, or surgery.

Hormonal birth control (eg, birth control pills) may not work as well while you are using Doxycycline. To prevent pregnancy, use an extra form of birth control (eg, condoms).

Doxycycline may interfere with certain lab tests. Be sure your doctor and lab personnel know you are using Doxycycline.

Pregnancy and breast-feeding: Doxycycline has been shown to cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Doxycycline while you are pregnant. Doxycycline is found in breast milk. Do not breastfeed while taking Doxycycline.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Loss of appetite; nausea; sensitivity to sunlight; vomiting.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); bloody stools; chest pain; dark urine; decreased urination; fever, chills, or sore throat; moderate to severe sunburn; severe diarrhea; severe or persistent headache; stomach pain or cramps; throat irritation; trouble swallowing; unusual bruising or bleeding; unusual joint pain; unusual tiredness; vaginal irritation or discharge; vision changes; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Comar Chemicals - Neodymium Versatate, Versatic

Our Neodymium Carboxylate is used to manufacture a Ziegler-Natta catalyst, required for the polymerisation of butadiene. The Neodymium Catalyst is reacted with a chlorine donor, such as a Di-alkyl Aluminium Chloride, or Ethyl Aluminium Sesquichloride (EASC), as well as an aluminium activator, such as a Di-alkyl Aluminium Hydride.

The product manufactured with our Neodymium catalyst is a high CIS content, high impact resistant Butadiene Rubber suitable for tyre manufacture and other applications. Comar Chemicals manufactures its Neodymium Catalyst with a unique chemical procedure, unlike the chemical processes which are used to manufacture other Neodymium Catalysts that are available commercially elsewhere.

TECHNICAL ADVANTAGES

Compared with commercially available Neodymium Catalysts, the advantages relating to Comar’s product are.

The catalyst exhibits a very high activity in polymerising butadiene. Typically over 95 % conversion efficiencies are achieved in 30 minute polymerisation tests.

The Butadiene Rubber has CIS contents in excess of 98 %, and the rubber molecules exhibit a high degree of linearity, leading to favourable physical properties.

The Butadiene Rubber molecular weight distribution is narrow, which has positive advantages in physical properties of the rubber, as well as allowing the long-term continuous runnability of the rubber manufacturing process.

The liquid Neodymium catalyst is stable at high solids contents over long time periods, and will maintain its catalytic efficiency in liquid storage for 2 years or longer. Precipitation of an inactive Neodymium Sludge from the liquid catalyst will not occur. In Comar’s Neodymium catalyst, no excess additives of any kind are used to manipulate product stability, and hence no concern exists as to how these additives may interfere with the formation of the active catalyst complex.

The high activity of Comar’s Neodymium Catalyst allows for the optimisation of the Neodymium to Aluminium ratios to levels not commonly reported in literature, thereby reducing overall catalysts system costs.

TRADE NAME

Comar’s Neodymium Catalysts are typically supplied with a Neodymium metal content of 8.8 %, and a total solids content of 40 %. The product is traded as COMCAT Nd-8.8 (V), in case of our Neodymium Neodecanoate. Other carboxylic acids may also be used for the manufacture of the Neodymium Carboxylate. Hexane, or Cyclohexane is used as a solvent for the catalyst. Other solvents may also be specified. Full Technical Specifications, Material Safety Data Sheets and samples of this material are available on request.

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