Lovalip, Lovalip

Lovalip

Lovalip - General Information

A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (hydroxymethylglutaryl COA reductases), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver. [PubChem]

Pharmacology of Lovalip

Lovalip, an antilipemic agent produced by fermentation of Aspergillus terreus . is the first of a class of lipid-lowering agents known as the HMG-CoA reductase inhibitors. Lovalip is used to treat hypercholesterolemia, to slow coronary atherosclerosis, and to prevent myocardial infarction and stroke. Lovalip, like simvastin and unlike pravastatin, is a prodrug, concentrating active drug in the liver during first-pass circulation.

Lovalip for patients

Lovastatin is used to lower high cholesterol levels. This medication should not be taken if you are pregnant, nursing, or have liver disease. Lovastatin should be taken with the evening meal. This medication may cause increased sensitivity to sunlight. Use sunscreens and wear protective clothing until degree of sensitivity is determined. Notify your physician if you develop blurred vision; skin rash; muscle pain. weakness, or cramps; unexplained fever, or yellowing of the skin or eyes.

Patients should be advised about substances they should not take concomitantly with lovastatin and be advised to report promptly unexplained muscle pain , tenderness, or weakness (see list below and WARNINGS, Myopathy/Rhabdomyolysis ). Patients should also be advised to inform other physicians prescribing a new medication that they are taking MEVACOR.

Lovalip Interactions

Lovastatin is metabolized by CYP3A4 but has no CYP3A4 inhibitory activity; therefore it is not expected to affect the plasma concentrations of other drugs metabolized by CYP3A4. Potent inhibitors of CYP3A4 (below) increase the risk of myopathy by reducing the elimination of lovastatin.

Pharmacokinetics. Itraconazole Ketoconazole Erythromycin Clarithromycin Telithromycin HIV protease inhibitors Nefazodone Cyclosporine Large quantities of grapefruit juice (>1 quart daily)

Interactions with lipid-lowering drugs that can cause myopathy when given alone.

The risk of myopathy is also increased by the following lipid-lowering drugs that are not potent CYP3A4 inhibitors, but which can cause myopathy when given alone.

See WARNINGS, Myopathy/Rhabdomyolysis. Gemfibrozil Other fibrates Niacin (nicotinic acid) (=1 g/day)

Other drug interactions

Danazol: The risk of myopathy/rhabdomyolysis is increased by concomitant administration of danazol particularly with higher doses of lovastatin (see WARNINGS, Myopathy/Rhabdomyolysis).

Amiodarone or Verapamil: The risk of myopathy/rhabdomyolysis is increased when either amiodarone or verapamil is used concomitantly with a closely related member of the HMG-CoA reductase inhibitor class (see WARNINGS, Myopathy/Rhabdomyolysis).

Coumarin Anticoagulants: In a small clinical trial in which lovastatin was administered to warfarin treated patients, no effect on prothrombin time was detected. However, another HMG-CoA reductase inhibitor has been found to produce a less than two-second increase in prothrombin time in healthy volunteers receiving low doses of warfarin. Also, bleeding and/or increased prothrombin time have been reported in a few patients taking coumarin anticoagulants concomitantly with lovastatin. It is recommended that in patients taking anticoagulants, prothrombin time be determined before starting lovastatin and frequently enough during early therapy to insure that no significant alteration of prothrombin time occurs. Once a stable prothrombin time has been documented, prothrombin times can be monitored at the intervals usually recommended for patients on coumarin anticoagulants. If the dose of lovastatin is changed, the same procedure should be repeated. Lovastatin therapy has not been associated with bleeding or with changes in prothrombin time in patients not taking anticoagulants.

Propranolol: In normal volunteers, there was no clinically significant pharmacokinetic or pharmacodynamic interaction with concomitant administration of single doses of lovastatin and propranolol.

Digoxin: In patients with hypercholesterolemia, concomitant administration of lovastatin and digoxin resulted in no effect on digoxin plasma concentrations.

Oral Hypoglycemic Agents: In pharmacokinetic studies of MEVACOR in hypercholesterolemic noninsulin dependent diabetic patients, there was no drug interaction with glipizide or with chlorpropamide

Lovalip Contraindications

Hypersensitivity to any component of this medication.

Active liver disease or unexplained persistent elevations of serum transaminases

Pregnancy and Lactation: Atherosclerosis is a chronic process and the discontinuation of lipid-lowering drugs during pregnancy should have little impact on the outcome of long-term therapy of primary hypercholesterolemia. Moreover, cholesterol and other products of the cholesterol biosynthesis pathway are essential components for fetal development, including synthesis of steroids and cell membranes. Because of the ability of inhibitors of HMG-CoA reductase such as lovastatin to decrease the synthesis of cholesterol and possibly other products of the cholesterol biosynthesis pathway, lovastatin is contraindicated during pregnancy and in nursing mothers. Lovastatin should be administered to women of childbearing age only when such patients are highly unlikely to conceive. If the patient becomes pregnant while taking this drug, lovastatin should be discontinued immediately and the patient should be apprised of the potential hazard to the fetus

Additional information about Lovalip

Lovalip Indication: For management as an adjunct to diet to reduce elevated total-C, LDL-C, apo B, and TG levels in patients with primary hypercholesterolemia and mixed dyslipidemia; For primary prevention of coronary heart disease Mechanism Of Action: Lovalip is a lactone that is readily hydrolyzed in vivo to the corresponding b-hydroxyacid, a potent inhibitor of HMG-CoA reductase, the enzyme that catalyzes the conversion of HMG-CoA to mevalonate. The conversion of HMG-CoA to mevalonate is an early step in the biosynthetic pathway for cholesterol. Drug Interactions: Amprenavir Amprenavir can possibly increase the statin toxicity Anisindione The statin increases the anticoagulant effect Acenocoumarol The statin increases the anticoagulant effect Dicumarol The statin increases the anticoagulant effect Warfarin The statin increases the anticoagulant effect Atazanavir Increased risk of myopathy/rhabdomyolysis Azithromycin Azithromycin can possibly increase the statin toxicity Bezafibrate Increased risk of myopathy/rhabdomyolysis Bosentan Bosentan could decrease the statin effect Carbamazepine Carbamazepine decreases the effect of the statin Colchicine Increased risk of rhabdomyolysis with this combination Cyclosporine Possible myopathy and rhabdomyolysis Danazol Risk of severe myopathy/rhabdomyolysis with this combination Diltiazem Diltiazem increases the effect and toxicity of the statin Fenofibrate Increased risk of myopathy/rhabdomyolysis Fluconazole Increased risk of myopathy/rhabdomyolysis Fosamprenavir Amprenavir can possibly increase the statin toxicity Gemfibrozil Increased risk of myopathy/rhabdomyolysis Imatinib Imatinib increases the effect and toxicity of statin Itraconazole Increased risk of myopathy/rhabdomyolysis Ketoconazole Increased risk of myopathy/rhabdomyolysis Nefazodone Nefazodone increases the effect and toxicity of the statin Nelfinavir Nelfinavir increases the effect and toxicity of the statin Niacin Risk of severe myopathy/rhabdomyolysis with this combination Quinupristin This combination presents an increased risk of toxicity Ritonavir Ritonavir increases the effect and toxicity of the statin Verapamil Verapamil increases the effect and toxicity of statin Telithromycin Telithromycin may possibly increase statin toxicity Tacrolimus Tacrolimus increases the effect and toxicity of the statin Clarithromycin The macrolide possibly increases the statin toxicity Erythromycin The macrolide possibly increases the statin toxicity Josamycin The macrolide possibly increases the statin toxicity Delavirdine The NNRT inhibitor increases the effect and toxicity of the statin Efavirenz The NNRT inhibitor increases the effect and toxicity of the statin Nevirapine The NNRT inhibitor increases the effect and toxicity of the statin Rifabutin The rifamycin decreases the effect of statin drug Rifampin The rifamycin decreases the effect of statin drug Food Interactions: Avoid drastic changes in dietary habit. Avoid alcohol. Take with food, 50% increase in bioavailability when taken with food. Avoid taking with grapefruit juice. Generic Name: Lovastatin Synonyms: Lovastatina [Spanish]; Lovastatine [French]; Lovastatinum [Latin]; 6 alpha-Methylcompactin Drug Category: Antineoplastic Agents; Anticholesteremic Agents; HMG-CoA Reductase Inhibitors Drug Type: Small Molecule; Approved Other Brand Names containing Lovastatin: Altocor; Altoprev; Artein; Belvas; Cholestra; Closterol; Colevix; Hipolip; Hipovastin; Lestatin; Lipdip; Lipivas; Lipofren; Lovalip; Lovalord; Lovasterol; Lovastin; Lozutin; Mevacor; Mevinacor; Mevlor; Monacolin K; Nergadan; Paschol; Rodatin; Rovacor; Sivlor; Taucor; Tecnolip; Teroltrat; Absorption: 30% Toxicity (Overdose): LD 50 >1000 mg/kg (orally in mice) Protein Binding: >95% Biotransformation: hepatic Half Life: 5.3 hours Dosage Forms of Lovalip: Tablet Oral Chemical IUPAC Name: [(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate Chemical Formula: C24H36O5 Lovastatin on Wikipedia: http://en. wikipedia. org/wiki/Lovastatin Organisms Affected: Humans and other mammals

Buy Sertrapel - Sertraline - Online Without Prescriptions, Sertrapel

Zoloft (Sertrapel)

Zoloft is used for treating depression or obsessive-compulsive disorder (OCD). It may be used to treat panic disorder or posttraumatic stress disorder (PTSD). It may also be used to treat premenstrual dysphoric disorder (PMDD; a severe form of premenstrual syndrome) or social anxiety disorder. Zoloft is a selective serotonin reuptake inhibitor (SSRI). It works by restoring the balance of serotonin, a natural substance in the brain, which helps to improve certain mood problems.

Use Zoloft as directed by your doctor.

Take Zoloft by mouth with or without food.

Taking Zoloft at the same time each day will help you remember to take it.

Continue to take Zoloft even if you feel well. Do not miss any dose.

Do not suddenly stop taking Zoloft without checking with your doctor. Side effects may occur. They may include mental or mood changes, numbness or tingling of the skin, dizziness, confusion, headache, trouble sleeping, or unusual tiredness. You will be closely monitored when you start Zoloft and whenever a change in dose is made.

If you miss a dose of Zoloft, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Zoloft.

Store Zoloft at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Zoloft out of the reach of children and away from pets.

Active Ingredient: Sertraline hydrochloride.

Do NOT use Zoloft if:

you are allergic to any ingredient in Zoloft

you are taking or have taken a monoamine oxidase inhibitor (MAOI) (eg, phenelzine), selegiline, or St. John's wort within the last 14 days

you are taking a fenfluramine derivative (eg, dexfenfluramine), an H 1 antagonist (eg, astemizole, terfenadine), nefazodone, pimozide, sibutramine, or thioridazine.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Zoloft. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you or a family member has a history of bipolar disorder (manic-depression), other mental or mood problems, suicidal thoughts or attempts, or alcohol or substance abuse

if you have a history of seizures, heart problems, liver problems, stomach or bowel bleeding, or metabolism problems

if you are dehydrated, have low blood sodium levels, or drink alcohol

if you will be having electroconvulsive therapy (ECT).

Some medicines may interact with Zoloft. Tell your health care provider if you are taking any other medicines, especially any of the following:

Anorexiants (eg, phentermine), fenfluramine derivatives (eg, dexfenfluramine), linezolid, MAOIs (eg, phenelzine), metoclopramide, nefazodone, selegiline, serotonin 5-HT 1 receptor agonists (eg, sumatriptan), sibutramine, St. John's wort, or trazodone because severe side effects, such as a reaction that may include fever, rigid muscles, blood pressure changes, mental changes, confusion, irritability, agitation, delirium, and coma, may occur

Anticoagulants (eg, warfarin), aspirin, or nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen) because the risk of bleeding, including stomach bleeding, may be increased

Diuretics (eg, furosemide, hydrochlorothiazide) because the risk of high or low blood sodium levels may be increased

Tramadol because the risk of seizures may be increased

H 1 antagonists (eg, astemizole, terfenadine) or phenothiazines (eg, chlorpromazine, thioridazine) because severe heart problems, including irregular heartbeat, may occur

Carbamazepine or cyproheptadine because they may decrease Zoloft's effectiveness

Aripiprazole, clozapine, digoxin, flecainide, lithium, phenytoin, pimozide, propafenone, risperidone, tricyclic antidepressants (eg, amitriptyline), or valproate (eg, valproic acid) because the risk of their side effects may be increased by Zoloft.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Zoloft may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Zoloft may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Zoloft with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Do not drink alcohol while you are taking Zoloft.

Check with your doctor before you use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are taking Zoloft; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.

Several weeks may pass before your symptoms improve. Do NOT take more than the recommended dose, change your dose, or use Zoloft for longer than prescribed without checking with your doctor.

Children and teenagers who take Zoloft may be at increased risk for suicidal thoughts or actions. Adults may also be affected. The risk may be greater in patients who have had suicidal thoughts or actions in the past. The risk may also be greater in patients who have had bipolar (manic-depressive) illness, or if their family members have had it. Watch patients who take Zoloft closely. Contact the doctor at once if new, worsened, or sudden symptoms such as depressed mood; anxious, restless, or irritable behavior; panic attacks; or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur.

If your doctor tells you to stop taking Zoloft, you will need to wait for several weeks before beginning to take certain other medicines (eg, MAOIs, nefazodone). Ask your doctor when you should start to take your new medicines after you have stopped taking Zoloft.

Zoloft may rarely cause a prolonged, painful erection. This could happen even when you are not having sex. If this is not treated right away, it could lead to permanent sexual problems such as impotence. Contact your doctor right away if this happens.

Serotonin syndrome is a possibly fatal syndrome that can be caused by Zoloft. Your risk may be greater if you take Zoloft with certain other medicines (eg, "triptans," MAOIs). Symptoms may include agitation; confusion; hallucinations; coma; fever; fast or irregular heartbeat; tremor; excessive sweating; and nausea, vomiting, or diarrhea. Contact your doctor at once if you have any of these symptoms.

Neuroleptic malignant syndrome (NMS) is a possibly fatal syndrome that can be caused by Zoloft. Symptoms may include fever; stiff muscles; confusion; abnormal thinking; fast or irregular heartbeat; and sweating. Contact your doctor at once if you have any of these symptoms.

Caution is advised when using Zoloft in the elderly; they may be more sensitive to its effects, especially low blood sodium levels.

Caution is advised when using Zoloft in children; they may be more sensitive to its effects, especially increased risk of suicidal thoughts or actions.

Zoloft should be used with extreme caution in children younger 6 years; safety and effectiveness in these children have not been confirmed.

Zoloft may cause weight changes. Children and teenagers may need regular weight and growth checks while they take Zoloft.

Pregnancy and breast-feeding: Zoloft may cause harm to the fetus if it is used during the last 3 months of pregnancy. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Zoloft while you are pregnant. It is not known if Zoloft is found in breast milk. If you are or will be breast-feeding while you use Zoloft, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Anxiety; constipation; decreased sexual desire or ability; diarrhea; dizziness; drowsiness; dry mouth; increased sweating; loss of appetite; nausea; nervousness; stomach upset; tiredness; trouble sleeping; vomiting; weight loss.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bizarre behavior; black or bloody stools; chest pain; confusion; decreased bladder control; decreased concentration; decreased coordination; exaggerated reflexes; fainting; fast or irregular heartbeat; fever; hallucinations; memory loss; new or worsening agitation, panic attacks, aggressiveness, impulsiveness, irritability, hostility, exaggerated feeling of well-being, restlessness, or inability to sit still; persistent or severe ringing in the ears; persistent, painful erection; red, swollen, blistered, or peeling skin; seizures; severe or persistent anxiety or trouble sleeping; severe or persistent headache; stomach pain; suicidal thoughts or attempts; tremor; unusual bruising or bleeding; unusual or severe mental or mood changes; unusual weakness; vision changes; worsening of depression.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Lasix - Blood Pressure, Spmc Frusemide

Blood Pressure - Spmc frusemide (Brand name: lasix)

Furosemide is a loop diuretic causing fast and short diuresis. It possesses natriuretic effect and also decreases levels of Cl - in blood, increases excretion of K+, Ca2+, Mg2+. Penetrating into a renal tubule in ascending thick limb of Henle's loop it blocks re-absorption of Na+ and Cl-. Due to increased excretion of Na+ secondary intensified excretion of water occurs and as well as increased secretion of K+ in distal part of the renal tubule. Simultaneously excretion of Ca2+ and Mg2+ increases. Furosemide is used to treat edema syndrome in patients with chronic heart failure (degree II and III), cirrhosis, diseases of kidneys, acute heart failure (pulmonary edema), brain edema, hypertensive crisis, arterial hypertension and others.

Dosage and direction Take exactly as it was prescribed by your doctor.

Precautions Before using Furosemide, consult your doctor if you suffer from kidney disease, liver disease, gout, lupus, diabetes, or an allergy to sulfa drugs. Avoid becoming dehydrated as Furosemide makes you urinate more often. Do not stop taking the drug even if you feel fine as high blood pressure often has no symptoms. Avoid taking the drug if you are pregnant or breastfeeding.

Contraindications Hypersensitivity, acute kidney failure with anuria, severe liver failure, liver coma and precoma, stenois of urethra, acute glomerulonephritis, urinary tract obstruction, precoma, hyperglycemic coma, gout, arterial hypotension, heart attack, pancreatitis and others.

Possible side effect Contact your physician for medical attention if you have signs of allergy or any of the following conditions: dry mouth, thirst, nausea, vomiting; weakness, drowsiness, restless, or light-headed, fast or uneven heartbeat, muscle pain, less than usual urination or absence of urination, easy bruising or bleeding, red blistering skin rash, hair loss.

Drug interaction Hearing damage may occur if Furosemide is administered with aminoglycoside antibiotics (gentamicin and others) or Edecrin - another diuretic. Concomitant use of Furosemide and aspirin may cause high blood levels of aspirin and aspirin toxicity. Furosemide is able to reduce excretion of lithium by the kidneys. Sucralfate (Carafate) reduces the action of Furosemide. Intake of Ingestion of Furosemide and Sucralfate should be separated by two hours.

Missed dose The medication is sometimes administered for single use so you will not need a dosing schedule. If you take Furosemide regularly and forgot to take a dose, take it as soon as you remember. Skip the missed dose if it is almost time for the next intake. Resume your regular schedule. Do not compensate the missed dose by taking an extra one.

Overdose In case of loss of appetite, ringing in ears, severe weakness, dizziness, confusion, lightheadedness, or fainting, seek for immediate doctor's attention.

Storage Keep away from children at room temperature in a dry and dark place.

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Furosemide is a loop diuretic causing fast and short diuresis. It possesses natriuretic effect and also decreases levels of Cl - in blood, increases excretion of K+, Ca2+, Mg2+. Penetrating into a renal tubule in ascending thick limb of Henle's loop it blocks re-absorption of Na+ and Cl-. Due to increased excretion of Na+ secondary intensified excretion of water occurs and as well as increased secretion of K+ in distal part of the renal tubule. Simultaneously excretion of Ca2+ and Mg2+ increases. Furosemide is used to treat edema syndrome in patients with chronic heart failure (degree II and III), cirrhosis, diseases of kidneys, acute heart failure (pulmonary edema), brain edema, hypertensive crisis, arterial hypertension and others.

Dosage and direction Take exactly as it was prescribed by your doctor.

Precautions Before using Furosemide, consult your doctor if you suffer from kidney disease, liver disease, gout, lupus, diabetes, or an allergy to sulfa drugs. Avoid becoming dehydrated as Furosemide makes you urinate more often. Do not stop taking the drug even if you feel fine as high blood pressure often has no symptoms. Avoid taking the drug if you are pregnant or breastfeeding.

Contraindications Hypersensitivity, acute kidney failure with anuria, severe liver failure, liver coma and precoma, stenois of urethra, acute glomerulonephritis, urinary tract obstruction, precoma, hyperglycemic coma, gout, arterial hypotension, heart attack, pancreatitis and others.

Possible side effect Contact your physician for medical attention if you have signs of allergy or any of the following conditions: dry mouth, thirst, nausea, vomiting; weakness, drowsiness, restless, or light-headed, fast or uneven heartbeat, muscle pain, less than usual urination or absence of urination, easy bruising or bleeding, red blistering skin rash, hair loss.

Drug interaction Hearing damage may occur if Furosemide is administered with aminoglycoside antibiotics (gentamicin and others) or Edecrin - another diuretic. Concomitant use of Furosemide and aspirin may cause high blood levels of aspirin and aspirin toxicity. Furosemide is able to reduce excretion of lithium by the kidneys. Sucralfate (Carafate) reduces the action of Furosemide. Intake of Ingestion of Furosemide and Sucralfate should be separated by two hours.

Missed dose The medication is sometimes administered for single use so you will not need a dosing schedule. If you take Furosemide regularly and forgot to take a dose, take it as soon as you remember. Skip the missed dose if it is almost time for the next intake. Resume your regular schedule. Do not compensate the missed dose by taking an extra one.

Overdose In case of loss of appetite, ringing in ears, severe weakness, dizziness, confusion, lightheadedness, or fainting, seek for immediate doctor's attention.

Storage Keep away from children at room temperature in a dry and dark place.

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Hemokvin - Tablete Za Pritisak, Hemokvin

Hemokvin – tablete za pritisak

Lek Hemokvin kao aktivne supstance sadzi kvinapril i hidrohlorotiazid. Pomocne supstance su laktoza monohidrat, magnezijum karbonat, povidon K25, krospovidon i magnezium stearat.

Dejstvo leka

Hemokvin spada u grupu lekova inhibitora AKE koji uticu na krvne sudove i tako smanjuju krvni pritisak.

Koristi se kod pacijenata sa visokim krvnim pritiskom.

Kontraindikacije

Informisite se kod Vaseg lekara ako imate neku hronicnu bolest, ako koristite jos neke lekove, ako imate neki poremecaj u metabolizmu, jer je moguce da ce doze biti prilagodjene, ili ce Vam biti savetovana primena nekog drugog leka.

Nemojte da upotrebljavate Hemokvin ako:

-Ste alergicni (preosetlivi) na bilo koji od sostojaka leka, kao i na druge inhibitore AKE, tiazidne diuretike i na lekove koji su derivati sulfonamida;

-Ako ste imalu angioedem (otok koze, lica, usana, usana)

– U slucaju da imate aortalnu stenozu, bubreznu insuficijenciju, hiperkaliemiju (povecan nivo kalijuma u krvi).

Upotreba leka u trudnoci i dojenje

Nemojte koristiti Hemokvin tablete akoste u drugom stanju, planirate trudnocu ili dojite. Uzimanje leka tokom prvog i treceg trimestra trudnoce moze ostetiti plod. Mala kolicina leka se izlucuje u majcino mleko.

Mere opreza

Lek se oprezno primenjuje ako imate oboljenje bubrega ili ste na dijalizi, ako uzimate jos neke lekove za pritisak . ako bolujete od lupusa, dermatomiozitisa, eritematodesa, poliarteritisa nodoze; zatim ako bolujete od gihta ili secerne bolesti, imate alergiju ili astmu.

Oprez je potreban i ako planirate postupak za odstranjivanje holesterola u krvi, ako lecite reakcije na ubod insekata, ako pijete alkohol u vecim kolicinama jer ovaj lek ce u tom slucaju imati pojacano dejstvo. Ne koristite alkohol za vreme terapije ovim lekom.

Ako ne podnosite laktozu, obratite se lakru za savet. Takodje, ako ovaj lek kod vasizazivavrtoglavicu ili zamor, nemojte voziti niti upravljati masinama.

Upotreba drugih lekova

Recite Vasem lekaru ako uzimate neki od sledecih lekova:

-lekovi za smanjenje krvnog pritiska, tetraciklini (antibiotici); litijum, soli kalijuma, sistemski kortikosteroidi (na primer: hidrokortizon, deksametazon ili prednizolon); ACTH; nesteroidni antiinflamatorni lekovi (primer: aspirin, ibuprofen ); prokainamid, citostatici ili imunosupresivi, alopurinol, diuretici, simpatikomimetici, antidijabetici, antacidni lekovi, sedativi.

Doziranje

Hemokvin tablete se piju uz obrok ili izmedju obroka sa malo tecnosti. Najbolje je da lek pijete svakog dana u isto vreme, ujutru.

Uobicajena doza je jedna tableta jednom dnevno.

Ako ste uzeli vecu kolicinu leka od propisane – odmah se javite lekaru.

Ako ste zaboravili da uzmete Hemokvin, ne duplirajte sledecu dozu vec lek uzmite cim se setite i nastavite uobicajenim rasporedom.

Nuspojave

Nezeljena dejstva na lek su: Angioedem, kada se odmah morate javiti lekaru, zatim neutropenija/agranulocitoza (smanjeni broj belih krvnih zrnaca), hipotenzija (nizak krvni pritisak), obojenost beonjaca, bol ustomaku, slabost u rukama i zglobovima, suvo grlo, nadutost stomaka, dijareja, poremecaj varenja, smanjena kolicina natrijuma u krvi, glavobolja, nesanica, crvenilo, bol u misicima, bronhitis, virusne infekcije, slabost, zamor, Steven-Johnson-ov sindrom i sistemski lupus eritematozus, oboljenja bubrega…

Proizvodjac leka je Hemofarm Vrsac.

Cena leka je oko 700 dinara.

Paralelni lek ( zamena ) je Kvinapril.

Napomena: Ovaj tekst je informativnog karaktera i ne zamenjuje misljenje strucnjaka. Pre primene leka, obavezno procitati uputstvo za upotrebu . O indikacijama, merama opreza i nezeljenim reakcijama na lek, posavetujte se sa lekarom ili farmaceutom.

SRODNI POSTOVI:

Trilipix Oral Uses, Side Effects, Interactions, Pictures, Warnings - Dosing, Trilipix

Trilipix

GENERIC NAME(S): FENOFIBRIC ACID (CHOLINE)

Uses

Fenofibric acid is used along with a proper diet to help lower "bad" cholesterol and fats (such as LDL. triglycerides ) and raise "good" cholesterol (HDL) in the blood. It works by increasing the natural substance (enzyme) that breaks down fats in the blood. Fenofibric acid belongs to a group of drugs known as "fibrates." Lowering triglycerides in people with very high triglyceride blood levels may decrease the risk of pancreas disease (pancreatitis ). However, fenofibric acid might not lower your risk of a heart attack or stroke. Talk to your doctor about the risks and benefits of fenofibric acid.

In addition to eating a proper diet (such as a low-cholesterol /low-fat diet), other lifestyle changes that may help this medication work better include exercising. losing weight if overweight. and stopping smoking. Consult your doctor for more details.

How to use Trilipix

Read the Medication Guide provided by your pharmacist before you start taking fenofibric acid and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth with or without food as directed by your doctor, usually once daily.

Swallow the capsules whole. Do not crush or chew the capsules. Doing so can release all of the drug at once, increasing the risk of side effects.

The dosage is based on your medical condition and response to treatment.

If you are also taking certain other drugs to lower your cholesterol (bile acid-binding resins such as cholestyramine or colestipol ), take fenofibric acid at least 1 hour before or at least 4 to 6 hours after taking these medications. These medications can bind to fenofibric acid, preventing your body from fully absorbing the drug.

Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. Do not increase your dose or use this drug more often or for longer than prescribed. Your cholesterol/triglycerides level will not lower faster, and your risk of side effects will increase. It is important to continue taking this medication even if you feel well. Most people with high cholesterol/triglycerides do not feel sick.

It is very important to continue to follow your doctor's advice about diet and exercise. It may take up to 2 months before you get the full benefit of this medication.

Side Effects

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

This medication may rarely cause gallstones and liver problems. If you notice any of the following unlikely but serious side effects, tell your doctor right away: persistent nausea /vomiting. loss of appetite, stomach /abdominal pain. yellowing eyes /skin. dark urine.

This drug may rarely cause muscle problems (which can rarely lead to a very serious condition called rhabdomyolysis ). Tell your doctor right away if you develop any of these symptoms: muscle pain /tenderness/weakness (especially with fever or unusual tiredness), signs of kidney problems (such as change in the amount of urine).

Rarely, this medication has caused severe lowering of HDL ("good" cholesterol) levels. This is the opposite of what should happen to your HDL levels (paradoxical reaction). Your HDL cholesterol levels should be checked regularly. Keep all of your laboratory appointments.

Tell your doctor right away if you have any serious side effects, including: easy bleeding/bruising, signs of infection (such as fever, persistent sore throat ), unusual tiredness.

Get medical help right away if you have any very serious side effects, including: chest pain. sudden pain/redness/swelling usually in the leg.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction. including: rash. itching /swelling (especially of the face/tongue /throat), severe dizziness. trouble breathing .

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking fenofibric acid, tell your doctor or pharmacist if you are allergic to it; or to other "fibrates" (such as fenofibrate ); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease (such as biliary cirrhosis. hepatitis ), gallbladder disease, alcohol use, kidney disease .

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

This medication is not recommended for use during pregnancy. It may harm an unborn baby. Discuss the risks and benefits with your doctor.

It is unknown if this medication passes into breast milk. Because of the possible risk to the infant, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.

Interactions

See also How to Use section.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: "blood thinners" (such as warfarin).

Fenofibric acid is very similar to fenofibrate. Do not use medications containing fenofibrate while using fenofibric acid.

Overdose

If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Notes

Do not share this medication with others.

Laboratory and/or medical tests (such as cholesterol/triglyceride levels, kidney/liver function tests, complete blood count) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details. (See also Side Effects section.)

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Information last revised May 2016. Copyright(c) 2016 First Databank, Inc.

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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Progesterone Gel Indications, Side Effects, Warnings, Progestogel

Progesterone gel

Treating certain women who do not menstruate. It may also be used for other conditions as determined by your doctor.

Progesterone gel is a hormone. It works by changing the lining of the uterus.

Do NOT use progesterone gel if:

you are allergic to any ingredient in progesterone gel

you have cancer of the breast, ovary, lining of the uterus, cervix, or vagina; a history of blood clots or clotting problems; vaginal bleeding of unknown cause; or liver disease; or you have had a stroke, a recent miscarriage, or bleeding in the brain

Contact your doctor or health care provider right away if any of these apply to you.

Before using progesterone gel:

Some medical conditions may interact with progesterone gel. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have heart or blood vessel problems, bleeding problems, high blood pressure, high cholesterol or lipid levels, diabetes, kidney problems, asthma, migraine headaches, or lupus

if you have a history of seizures, depression or other mental/mood problems, cancer, or tobacco use

if you have a family history of blood clots

if you are very overweight

Some MEDICINES MAY INTERACT with progesterone gel. Tell your health care provider if you are taking any other medicines, especially any of the following:

Rifampin because it may decrease progesterone gel's effectiveness

This may not be a complete list of all interactions that may occur. Ask your health care provider if progesterone gel may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use progesterone gel:

Use progesterone gel as directed by your doctor. Check the label on the medicine for exact dosing instructions.

An extra patient leaflet is available with progesterone gel. Talk to your pharmacist if you have questions about this information.

Review the patient insert for proper preparation and use of the vaginal applicator.

If you miss a dose of progesterone gel, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use progesterone gel.

Important safety information:

Progesterone gel may cause drowsiness, dizziness, blurred vision, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use progesterone gel with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

Progesterone gel may cause dark skin patches on your face. Exposure to the sun may make these patches darker. If patches develop, use a sunscreen or protective clothing when exposed to the sun, sunlamps, or tanning booths.

Do not use progesterone gel at the same time as other vaginal therapy without checking with your doctor. If other vaginal therapy is to be used, administer it 6 or more hours before or after progesterone gel, unless advised otherwise by your health care provider.

Progesterone gel may cause harm if it is swallowed. If you may have taken it by mouth, contact your poison control center or emergency room right away.

Diabetes patients - Progesterone gel may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

Lab tests, including monthly breast self-exams, yearly breast exams, Pap smears, and pelvic exams, may be performed while you use progesterone gel. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Progesterone gel should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.

PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using progesterone gel while you are pregnant. Progesterone gel is found in breast milk. If you are or will be breast-feeding while you use progesterone gel, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of progesterone gel:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Breast enlargement; breast pain; changes in sex drive; constipation; cramps; depression; diarrhea; difficult or painful sexual intercourse; drowsiness; fatigue; fluid retention/bloating; headache; increased appetite; joint pain; nausea; nervousness; pain around vaginal area; sleep disorder; urination at night; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal vaginal bleeding; breast lumps; calf/leg pain or tenderness; change in emotions, mood, or behavior; chest pain; coughing blood; dizziness; fainting; inflammation of the eye; numbness of arm or leg; one-sided weakness; pain in the groin; partial or complete loss of vision; seizure; stomach pain, swelling, or tenderness; sudden, severe headache, vomiting, dizziness, or fainting; sudden shortness of breath; swelling of hands, ankles, or feet; tremor; unusual vaginal discharge or odor; vaginal itching; visual or speech disturbances; weakness or numbness in an arm or leg; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA .

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center. or emergency room immediately.

Proper storage of progesterone gel:

Store progesterone gel at room temperature, below 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Keep progesterone gel out of the reach of children and away from pets.

General information:

If you have any questions about progesterone gel, please talk with your doctor, pharmacist, or other health care provider.

Progesterone gel is to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take progesterone gel or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about progesterone gel. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to progesterone gel. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using progesterone gel.

Review Date: August 8, 2016

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

More about progesterone

Vasodilan - Blood Pressure, Vasosuprina

Blood Pressure - Vasosuprina (Brand name: vasodilan)

Vasodilan is used for improving blood flow in some conditions (eg, cerebral vascular insufficiency, arteriosclerosis obliterans, Buerger disease, Raynaud disease). Vasodilan is a vasodilating agent. It works by relaxing and widening the blood vessels in muscles and other tissues, which helps to improve blood flow (circulation) in these muscles and tissues.

Use Vasodilan as directed by your doctor.

Vasodilan may be taken with or without food.

If you miss a dose of Vasodilan, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Vasodilan.

Store Vasodilan at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Vasodilan out of the reach of children and away from pets.

Active Ingredient: Isoxsuprine.

Do NOT use Vasodilan if:

you are allergic to any ingredient in Vasodilan

you have bleeding of the arteries

you are in labor or have just given birth.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Vasodilan. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have bleeding problems.

Some medicines may interact with Vasodilan. However, no specific interactions with Vasodilan are known at this time.

Important safety information:

Vasodilan may cause dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Vasodilan. Using Vasodilan alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.

Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Vasodilan.

Pregnancy and breast-feeding: If you become pregnant while taking Vasodilan, discuss with your doctor the benefits and risks of using Vasodilan during pregnancy. It is unknown if Vasodilan is excreted in breast milk. If you are or will be breast-feeding while you are using Vasodilan, check with your doctor or pharmacist to discuss the risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

When used in small doses, no common side effects have been reported with this product.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; fast or irregular heartbeat; severe or persistent dizziness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Vasodilan is used for improving blood flow in some conditions (eg, cerebral vascular insufficiency, arteriosclerosis obliterans, Buerger disease, Raynaud disease). Vasodilan is a vasodilating agent. It works by relaxing and widening the blood vessels in muscles and other tissues, which helps to improve blood flow (circulation) in these muscles and tissues.

Use Vasodilan as directed by your doctor.

Vasodilan may be taken with or without food.

If you miss a dose of Vasodilan, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Vasodilan.

Store Vasodilan at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Vasodilan out of the reach of children and away from pets.

Active Ingredient: Isoxsuprine.

Do NOT use Vasodilan if:

you are allergic to any ingredient in Vasodilan

you have bleeding of the arteries

you are in labor or have just given birth.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Vasodilan. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have bleeding problems.

Some medicines may interact with Vasodilan. However, no specific interactions with Vasodilan are known at this time.

Important safety information:

Vasodilan may cause dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Vasodilan. Using Vasodilan alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.

Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Vasodilan.

Pregnancy and breast-feeding: If you become pregnant while taking Vasodilan, discuss with your doctor the benefits and risks of using Vasodilan during pregnancy. It is unknown if Vasodilan is excreted in breast milk. If you are or will be breast-feeding while you are using Vasodilan, check with your doctor or pharmacist to discuss the risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

When used in small doses, no common side effects have been reported with this product.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; fast or irregular heartbeat; severe or persistent dizziness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Zovirax - Anti Viral, Renadinac

Product Description Common use Zovirax is an antiviral medication which used to treat herpes infections of the skin, lip, and genitals; herpes zoster; and chickenpox. Zovirax stops viral replication, but it does not work in treating certain virus infections, such as the common cold.

Dosage and direction Take it orally with or without food/milk. Commonly used dose is 200 mg every 4 hours, five times a day for ten days. If the herpes is recurrent, the recommended dose for adults is 400 mg two times a day for 1 year. Washing of your hands will help you to prevent passing the infection to others. Note: this instruction presented here just for review. It's very necessary to consult with your doctor before using. It help you to get best results.

Precautions Avoid letting infected areas come into contact with other people. Do not touch your eyes after touching an infected area. Do not use without doctor's permission if your medical history include: kidney disease or liver disease. Zovirax should not be used during pregnancy, becoming pregnant or lactating without doctor's advice. Do not use Zovirax before breast-feeding without doctor's advice.

Contraindications Zovirax is not allowed in patients with kidney disorders. Also Zovirax is contraindicated in people who are hypersensitive to Zovirax, Acyclovir or similar drugs.

Possible side effect They may include an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Also the most possible side effects include: pain in your lower back; urinating less than usual or not at all; easy bruising or bleeding; unusual weakness. Less serious include: nausea, vomiting, diarrhea, loss of appetite, stomach pain; headache, feeling light-headed; swelling in your hands or feet. If you experience one of them stop using Zovirax and tell your doctor as soon as possible. Also consult with your doctor about any side effect that seems unusual.

Drug interaction Zovirax interact with: probenecid (Benemid), Tizanidine, Varicella Virus Vaccine, Fosphenytoin, Phenytoin, Valproic Acid. Also note that interaction between two medications does not always mean that you must stop taking one of them. Usually it affects the effect of drugs, so consult your doctor about their interactions.

Missed dose If you forgot to take your dose in time, please do it as soon as possibe. But do not take if it is too late or almost time for your next dose. Do not take double or extra doses. Take your usual dose next day at the same time regularly.

Overdose Symptoms of Zovirax overdose include: seizure (convulsions), hallucinations, and urinating less than usually or not at all. If you experience one of them or any unusual symptom, call your doctor immediately.

Store at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture, kids and pets. Do not use after expiration term.

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care advisor or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Canaural Ear Drops (Canada) For Animal Use, Canoral

Canaural Ear Drops (Canada)

This page contains information on Canaural Ear Drops for veterinary use . The information provided typically includes the following:

Canaural Ear Drops Indications

Warnings and cautions for Canaural Ear Drops

Direction and dosage information for Canaural Ear Drops

Canaural Ear Drops

Ear drops suspension for dogs and cats

For Veterinary Use Only

Composition

Canaural ® is an oily suspension. Each gram suspension contains:

Properties: Canaural ® Ear Drops are specifically formulated for the treatment of otitis externa in the dog and cat.

Fusidic acid is an antibiotic which is highly active against Staphylococci . the most commonly found bacterial pathogen in otitis externa in the dog and cat. Fusidic acid has skin penetrating properties which enhances its antibacterial properties.

Framycetin sulphate is a broad spectrum antibiotic which has been incorporated for its activity against gram negative organisms associated with otitis externa, in particular Pseudomonas spp. and Proteus spp.

Nystatin is highly active against yeast. The yeast, Malassezia canis is associated with otitis externa in the dog and cat either by itself or with other organisms.

Prednisolone is incorporated for its anti-inflammatory activity.

Trials have determined that Canaural ® is effective in the treatment of the ear mite Otodectes cyonitis in the dog and cat. All four active ingredients are suspended in oil. A bland oil is used which softens and dissolves ceruminous material and readily penetrates the ear canal. Additionally the oil used does not matt the hair around the ear, which would prove objectionable to both the animal and owner.

Canaural Ear Drops Indications

Otitis externa in the dog and cat. Otodectes cynotis infestation in the dog and cat.

Contraindications

- Do not use in case of perforated eardrum.

- Do not use in case of hypersensitivity to the active substances or to the excipients.

- The safety of the veterinary medicinal product has not been established during pregnancy or lactation. The use is not recommended during pregnancy or lactation.

Canaural Ear Drops Cautions

- For external use only.

- The dogs scratching of the ears might need to be prevented.

- Where treatment is for a period longer than 7 days regular clinical re-evaluation should be carried out. Inappropriate use of the product might increase the prevalence of bacterial resistance and might lead to cross resistance.

- Hypersensitivity to any of the ingredients might develop. In case of hypersensitivity stop the treatment immediately.

- Anti-inflammatory corticosteroids such as prednisolone can exert a wide range of side effects. Dosage in medium to long term use should therefore generally be kept to the minimum. During therapy effective doses suppress the hypothalamic-pituiteal adrenal axis. Following end of treatment symptoms of adrenal insufficiency can arise and this may render the animal unable to deal adequately with stressful situations. Corticosteroids may delay wound healing and the immunosuppressant actions may weaken resistance to, or exacerbate existing infections.

Warnings

- KEEP OUT OF REACH OF CHILDREN.

- People with known hypersensitivity to the active ingredients should avoid contact with this product.

- Wash hands after use.

- Avoid contact with the eyes. If any splashes enter the eye, wash immediately with copious amounts of water.

Dosage and Administration

Shake the bottle before use.

5-10 drops of Canaural ® should be instilled into the ear canal twice daily. The ear flap should then be held and the ear canal gently massaged to ensure maximum penetration of the Canaural ® suspension.

Wash hands after use.

One 15 mL bottle will treat one ear for approximately two weeks.

The length of treatment will depend upon the individual case, but a maximum treatment period of 7 days is recommended.

Where ear mite infection is present, consideration should be given to treating both ears, even if infection is apparent in only one.

Treatment should continue for at least 3 weeks to ensure that successive generations of ear mites are killed. In contact animals should also be treated.

Following recovery the ears should be checked at regular intervals for any sign of re-infection.

Storage

Do not store above 25°C.

Protect from direct sunlight.

Presentation: Plastic squeeze dropper bottles, supplied in boxes of 1 x 15 mL or 1 x 25 mL.

Date of revision of the text: 03/2009

AVENTIX ANIMAL HEALTH CORP. . Burlington, Ontario L7L 5R7, Canada

Fluoxetine Advanced Patient Information, Anzolden

fluoxetine (Oral route)

Oral route(Capsule;Capsule, Delayed Release)

Antidepressants can increase the risk of suicidal thinking and behavior in children, adolescents, and young adults with major depressive disorder. Closely monitor patients of all ages for clinical worsening and emergence of suicidal thoughts and behaviors. When using Prozac and olanzapine in combination, also refer to the Boxed Warning section of the package insert for Symbyax(R) .

Antidepressants can increase the risk of suicidal thinking and behavior in children, adolescents, and young adults with major depressive disorder. Closely monitor patients of all ages for clinical worsening and emergence of suicidal thoughts and behaviors. Prozac(R) is approved for use in pediatric patients with MDD and obsessive compulsive disorder (OCD) .

Antidepressants can increase the risk of suicidal thinking and behavior in children, adolescents, and young adults with major depressive disorder. Closely monitor patients of all ages for clinical worsening and emergence of suicidal thoughts and behaviors. Sarafem(R) is not approved for use in pediatric patients .

Commonly used brand name(s)

Available Dosage Forms:

Therapeutic Class: Antidepressant

Pharmacologic Class: Serotonin Reuptake Inhibitor

Uses For fluoxetine

Fluoxetine is used to treat depression, obsessive-compulsive disorder (OCD), bulimia nervosa, premenstrual dysphoric disorder (PMDD), and panic disorder. It is also used together with olanzapine to treat depression that is part of bipolar disorder.

Fluoxetine is an antidepressant and belongs to a group of medicines known as selective serotonin reuptake inhibitors (SSRIs). fluoxetine works by increasing the activity of a chemical called serotonin in the brain.

fluoxetine is available only with your doctor's prescription.

Before Using fluoxetine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For fluoxetine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to fluoxetine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of fluoxetine in children. However, safety and efficacy have not been established to treat depression in children younger than 8 years of age, and to treat obsessive-compulsive disorder in children younger than 7 years of age.

Appropriate studies have not been performed on the relationship of age to the effects of fluoxetine in children with bulimia nervosa or panic disorder . Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of fluoxetine in the elderly. However, elderly patients are more likely to have hyponatremia (low sodium in the blood) than younger adults, which may require caution and an adjustment in the dose for patients receiving fluoxetine.

Pregnancy

Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking fluoxetine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using fluoxetine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Amifampridine

Bepridil

Cisapride

Clorgyline

Dronedarone

Furazolidone

Iproniazid

Isocarboxazid

Levomethadyl

Linezolid

Mesoridazine

Methylene Blue

Metoclopramide

Moclobemide

Nialamide

Pargyline

Phenelzine

Pimozide

Piperaquine

Procarbazine

Rasagiline

Saquinavir

Selegiline

Sparfloxacin

Terfenadine

Thioridazine

Toloxatone

Tranylcypromine

Ziprasidone

Using fluoxetine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Abciximab

Abiraterone

Acecainide

Aceclofenac

Acemetacin

Acenocoumarol

Ajmaline

Alfuzosin

Almotriptan

Amineptine

Amiodarone

Amisulpride

Amitriptyline

Amitriptylinoxide

Amoxapine

Amphetamine

Amtolmetin Guacil

Anagrelide

Ancrod

Anisindione

Antithrombin III Human

Apixaban

Apomorphine

Aprindine

Ardeparin

Argatroban

Aripiprazole

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Using fluoxetine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of fluoxetine. Make sure you tell your doctor if you have any other medical problems, especially:

Bipolar disorder (mood disorder with mania and depression), or risk of or

Bleeding problems or

Diabetes or

Glaucoma (angle-closure type) or

Hyponatremia (low sodium in the blood) or

Mania, history of or

Seizures, history of—Use with caution. May make these conditions worse.

Heart attack or stroke, recent or history of or

Heart failure or

Heart rhythm problems (eg, QT prolongation), or history of or

Hypokalemia (low potassium in the blood) or

Hypomagnesemia (low magnesium in the blood)—May cause side effects to become worse.

Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Proper Use of fluoxetine

Take fluoxetine only as directed by your doctor . to benefit your condition as much as possible. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

fluoxetine should come with a Medication Guide. It is very important that you read and understand this information. Be sure to ask your doctor about anything you do not understand.

You may take the medicine with or without food.

For some conditions, it may take a month or longer before you begin to feel better.

If you are using the oral liquid . shake the bottle well before measuring each dose. Measure the liquid with a marked measuring spoon, oral syringe, or medicine cup. A regular household teaspoon will not measure the proper amount of medicine.

Dosing

The dose of fluoxetine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of fluoxetine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (delayed-release capsules, pulvules, or solution):

For bulimia nervosa:

Adults—60 milligrams (mg) per day as a single dose in the morning.

Children—Use and dose must be determined by your doctor.

For depression:

Adults—At first, 20 milligrams (mg) per day as a single dose in the morning. Your doctor may adjust your dose as needed. However, the dose is usually not more than 80 mg per day. After a few weeks, your doctor may change you to a weekly dose of 90 mg, taken as a single dose one day per week.

Children 8 years of age and older—At first, 10 to 20 mg per day as a single dose in the morning. Your doctor may adjust your dose as needed.

Children younger than 8 years of age—Use and dose must be determined by your doctor.

For obsessive-compulsive disorder:

Adults—At first, 20 milligrams (mg) per day as a single dose in the morning. Your doctor may adjust your dose as needed. However, the dose is usually not more than 80 mg per day.

Children 7 years of age and older—At first, 10 mg per day as a single dose in the morning. Your doctor may adjust your dose as needed. However, the dose is usually not more than 60 mg per day.

Children younger than 7 years of age—Use and dose must be determined by your doctor.

For panic disorder:

Adults—At first, 10 milligrams (mg) per day as a single dose in the morning. Your doctor may adjust your dose as needed. However, the dose is usually not more than 60 mg per day.

Children—Use and dose must be determined by your doctor.

For premenstrual dysphoric disorder:

Adults—At first, 20 milligrams (mg) per day as a single dose in the morning. Your doctor may have you take 20 mg every day of your menstrual cycle or for only 15 days of your cycle. Your doctor may adjust your dose as needed. However, the dose is usually not more than 80 mg per day.

Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of fluoxetine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using fluoxetine

It is important that your doctor check your progress at regular visits . to allow changes in your dose and help reduce any side effects. Blood tests may be needed to check for unwanted effects.

Do not take fluoxetine with a monoamine oxidase (MAO) inhibitor (eg, isocarboxazid [Marplan®], linezolid [Zyvox®], methylene blue injection, phenelzine [Nardil®], selegiline [Eldepryl®], tranylcypromine [Parnate®]). Do not start taking fluoxetine during the 2 weeks after you stop a MAO inhibitor and wait 5 weeks after stopping fluoxetine before you start taking a MAO inhibitor. If you take them together or do not wait the proper amount of time, you may develop confusion, agitation, restlessness, stomach or intestinal symptoms, a sudden high body temperature, an extremely high blood pressure, or severe convulsions.

Do not take thioridazine (Mellaril®) with fluoxetine and wait 5 weeks after stopping fluoxetine before you start taking thioridazine. Do not use pimozide (Orap®) with fluoxetine. Using these medicines together can cause very serious heart problems.

Fluoxetine may cause a serious condition called serotonin syndrome if taken together with some medicines. Do not use fluoxetine with buspirone (Buspar®), fentanyl (Abstral®, Duragesic®), lithium (Eskalith®, Lithobid®), tryptophan, St. John's wort, or some pain or migraine medicines (eg, rizatriptan, sumatriptan, tramadol, Frova®, Imitrex®, Maxalt®, Relpax®, Ultram®, Zomig®). Check with your doctor first before taking any other medicines with fluoxetine .

Fluoxetine may cause some teenagers and young adults to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. Some people may have trouble sleeping, get upset easily, have a big increase in energy, or start to act reckless. If you or your caregiver notice any of these unwanted effects, tell your doctor right away. Let the doctor know if you or anyone in your family has bipolar disorder (manic-depressive) or has tried to commit suicide.

Do not suddenly stop taking fluoxetine without checking first with your doctor . Your doctor may want you to gradually reduce the amount you are using before stopping it completely. This will decrease the chance of having withdrawal symptoms such as agitation, breathing problems, chest pain, confusion, diarrhea, dizziness or lightheadedness, fast heartbeat, headache, increased sweating, muscle pain, nausea, restlessness, runny nose, trouble in sleeping, trembling or shaking, unusual tiredness or weakness, vision changes, or vomiting.

Tell your doctor right away if you develop a rash or hives, swelling of the face, eyes, or mouth, or trouble breathing after taking fluoxetine.

fluoxetine may increase your risk for bleeding problems. Make sure your doctor knows if you are also taking other medicines that thin the blood, such as aspirin, nonsteroidal antiinflammatory agents, also called NSAIDs (eg, diclofenac, ibuprofen, naproxen, Advil®, Aleve®, Celebrex®, Voltaren®), or warfarin (Coumadin®, Jantoven®).

Hyponatremia (low sodium in the blood) may occur with fluoxetine. Check with your doctor right away if you have confusion, difficulty concentrating, headaches, memory problems, weakness, and unsteadiness.

Contact your doctor right away if you have dizziness, fainting, or a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you have ever had a heart rhythm problem, such as QT prolongation, or if you or a family member has had a heart attack, heart failure, low blood pressure, or a stroke.

The use of alcohol is not recommended in patients who are taking fluoxetine.

For diabetic patients:

fluoxetine may affect blood sugar levels. If you are diabetic and notice a change in the results of your blood or urine sugar tests, check with your doctor.

fluoxetine may cause some people to become drowsy or less able to think clearly, or to have poor muscle control. Make sure you know how you react to fluoxetine before you drive, use machines, or do anything else that could be dangerous if you are not alert and well able to control your movements .

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

fluoxetine Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Hives, itching, or skin rash

inability to sit still

restlessness

Less common

Chills or fever

joint or muscle pain

Rare

Anxiety

cold sweats

confusion

convulsions (seizures)

cool pale skin

diarrhea

difficulty with concentration

drowsiness

dryness of the mouth

excessive hunger

fast or irregular heartbeat

headache

increased sweating

increased thirst

lack of energy

mood or behavior changes

overactive reflexes

purple or red spots on the skin

racing heartbeat

shakiness or unsteady walk

shivering or shaking

talking, feeling, and acting with excitement and activity you cannot control

trouble with breathing

unusual or incomplete body or facial movements

unusual tiredness or weakness

Incidence not known

Abdominal or stomach pain

agitation

back or leg pains

bleeding gums

blindness

blistering, peeling, or loosening of the skin

bloating

blood in the urine or stools

bloody, black or tarry stools

blue-yellow color blindness

blurred vision

chest pain or discomfort

clay-colored stools

constipation

continuing vomiting

cough or dry cough

dark urine

decreased urine output

decreased vision

depression

difficulty with breathing

difficulty with swallowing

dizziness or lightheadedness

eye pain

fainting

fast, pounding, or irregular heartbeat or pulse

general body swelling

high fever

hives, itching, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

hostility

indigestion

irregular or slow heart rate

irritability

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

light-colored stools

loss of appetite

loss of bladder control

muscle twitching

nausea

nightmares

no blood pressure or pulse

noisy breathing

nosebleeds

pain in the ankles or knees

painful, red lumps under the skin, mostly on the legs

pains in the stomach, side, or abdomen, possibly radiating to the back

pinpoint red spots on the skin

rapid weight gain

red or irritated eyes

red skin lesions, often with a purple center

redness, tenderness, itching, burning, or peeling of the skin

severe muscle stiffness

severe sleepiness

slurred speech

sore throat

sores, ulcers, or white spots on the lips or in the mouth

stopping of heart

sudden shortness of breath or troubled breathing

sudden weakness in the arms or legs

sudden, severe chest pain

swelling of the face, ankles, or hands

swollen or painful glands

thoughts of killing oneself

tightness in the chest

tiredness

twitching, twisting, or uncontrolled repetitive movements of the tongue, lips, face, arms, or legs

unconsciousness

unpleasant breath odor

unusual bleeding or bruising

unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

unusually pale skin

use of extreme physical or emotional force

vomiting of blood

yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Decreased appetite

Less common or rare

Abnormal dreams

breast enlargement or pain

change in sense of taste

changes in vision

feeling of warmth or heat

flushing or redness of the skin, especially on face and neck

frequent urination

hair loss

increased appetite

increased sensitivity of the skin to sunlight

menstrual pain

stomach cramps, gas, or pain

unusual secretion of milk, in females

weight loss

yawning

Incidence not known

Cracks in the skin

loss of heat from the body

painful or prolonged erections of the penis

scaly skin

swelling of the breasts or breast soreness in both females and males

unusual milk production

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Truven Health Micromedex products as delivered by Drugs. com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs. com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products.

Copyright 2016 Truven Health Analytics, Inc. All Rights Reserved.

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Dostinex Uses: Dostinex belongs to a class of medicines known as prolactin inhibitors. Prolactin inhibitors such as Dostinex are used to treat different types of medical problems that occur when too much of the hormone prolactin is produced by the pituitary gland, which is found in the brain. An excess production of prolactin can result in menstrual problems in women and fertility problems in men and women.

Dostinex stops the brain from making and releasing prolactin from the pituitary gland. Dostinex is also used to prevent the onset of normal lactation (milk production) in cases where there is a medical need to prevent lactation.

Your doctor may choose to use Dostinex for other conditions not listed here. If you're unsure why you are taking Dostinex, please ask your doctor.

When used to prevent the onset of normal lactation, the dose is 1 mg of Dostinex given as a single dose on the first day after having a baby.

For prolactin disorders, the recommended starting dose of Dostinex for adults is 0.5 mg per week, given in one or two doses per week (for two doses, the tablet is cut in half). The dose may be increased by 0.5 mg per week until a maximum of 2 mg per week is reached. The dose should not be increased more often than every four weeks. The eventual dose of the drug will depend on the results of lab tests that measure the amount of prolactin in your blood. After the tests have been in the normal range for at least six months, the doctor may decide to stop the medication and continue to monitor the levels of prolactin in the blood.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.

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Active Ingredients

Each tablet contains Cetirizine Hydrochloride Ph Eur 10mg.

Product Description

Allerid C is a rapid acting antihistamine which provides non-drowsy allergy relief. Take Allerid C to relieve the symptoms of seasonal rhinitis (hayfever) and conjunctivitis, perennia allergic rhinitis, urticaria of allergic origin and insect bites. Allerid C is available in a pack of 30 tablets.

Dosage

Adults and children over 6 years: One tablet (10mg) daily. Children 2-6 years: Half (1/2) of a tablet (5mg) daily.

Warnings and Cautions

Consult with your doctor or pharmacist before using Allerid C if you are pregnant or breast-feeding.

Keep Allerid C out of the reach of children.

Keep Allerid C in a cool, dry place. Store below 25?C/75?F. Protect from direct sunlight.

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Currently there are no prices listed for this product. The product may be unavailable at this time, or discontinued. Please contact us to request more information.

Bidroxyl, Bidroxyl

Cefadroxil fights bacteria in the body. Cefadroxil is used to treat many different types of bacterial infections such as bronchitis, tonsillitis, ear infections, skin infections, and urinary tract infections.

Use Cefadroxil as directed by your doctor.

Take Cefadroxil by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation. To clear up your infection completely, take Cefadroxil for the full course of treatment. Keep taking it even if you feel better in a few days. Ask your health care provider any questions you may have about how to use Cefadroxil. Drug Class and Mechanism

Cefadroxil is a cephalosporin antibiotic. It works by interfering with the bacteria's cell wall formation. This weakens the cell wall, causing it to rupture, resulting in death of the bacteria.

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Important : Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor. Be sure to use Cefadroxil for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future. Cefadroxil only works against bacteria; it does not treat viral infections (e. g. the common cold). Long-term or repeated use of Cefadroxil may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this. Diabetes patients - Cefadroxil may cause the results of some tests for urine glucose to be wrong. Ask your doctor before you change your diet or the dose of your diabetes medicine. Cefadroxil may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Cefadroxil. Pregnancy and breast-feeding: if you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Cefadroxil while you are pregnant. Cefadroxil is found in breast milk. If you are or will be breast-feeding while you use Cefadroxil. check with your doctor. Discuss any possible risks to your baby.

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Check with your doctor if any of these most common side effects persist or become bothersome:

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Cefadroxil is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor.

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Cefadroxilo

Propiedades.

El cefadroxilo es una cefalosporina de primera generaciпїЅn. Desarrolla su acciпїЅn preferentemente sobre gпїЅrmenes grampositivos y, con mucho menos frecuencia sobre gramnegativos. La Neisseria gonorrhoeae es especialmente sensible a esta cefalosporina.

Indicaciones.

Infecciones de los tractos respiratorio y genitourinario. Infecciones de piel y tejidos blandos.

DosificaciпїЅn.

Dosis usual para adultos: oral: faringitis y tonsilitis por estreptococos betahemolпїЅticos del grupo A: 500mg, cada 12 horas durante 10 dпїЅas. Infecciones de la piel y tejidos blandos: 500mg, cada 12 horas, o 1g una vez al dпїЅa. Infecciones del tracto urinario: de 500mg a 1g cada 12 horas, o de 1g a 2g una vez al dпїЅa. NiпїЅos de menos de 40kg: 50mg/kg/dпїЅa, repartidos en 2 tomas. En infecciones graves puede administrarse hasta 100mg/kg/dпїЅa, repartidos en 2 o 3 tomas.

Reacciones adversas.

Trastornos gastrointestinales, nпїЅuseas, vпїЅmitos y diarrea. Reacciones dermatolпїЅgicas por hipersensibilidad. Sobreinfecciones por microorganismos no susceptibles (cпїЅndida, seudomonas). Ocasionalmente: nefrotoxicidad (cilindruria, proteinuria y hematuria).

Precauciones y advertencias.

Hipersensibilidad a las penicilinas. En insuficiencia renal grave, reducir las dosis; en especial si se usa en dosis elevadas o junto con agentes nefrotпїЅxicos.

Interacciones.

El probenecid potencia su acciпїЅn al disminuir su secreciпїЅn tubular. Puede inhibirse su acciпїЅn por la administraciпїЅn simultпїЅnea de agentes bacteriostпїЅticos (tetraciclinas, cloranfenicol, sulfamidas). Los antibiпїЅticos aminoglucпїЅsidos, la furosemida y el пїЅcido etacrпїЅnico aumentan su nefrotoxicidad.

Contraindicaciones.

Hipersensibilidad a las cefalosporinas. NiпїЅos menores de 1 mes.

Interacciones

Cefadroxilo interactuando con AcetilsalicпїЅlico пїЅcido

Cefadroxilo interactuando con Antiagregantes plaquetarios

Cefadroxilo interactuando con AntibiпїЅticos aminoglucпїЅsidos

Cefadroxilo interactuando con NefrotпїЅxicos, fпїЅrmacos

Commentator Vs, Comenter

Commentator vs. commenter

A commenter is someone who makes isolated comments. These days, the word most often refers to people who post comments on blogs and news websites. A commentator is someone who provides commentary. The term usually applies to professionals in sports broadcasting or television news. Commentators don’t just make one comment; commenting is what they do.

The difference between these words corresponds to the difference between a comment and commentary. A comment is an isolated remark, while a commentary is a series of remarks, explanations, and interpretations.

Examples

When we talked a bit about reducing food-related waste, one commenter mentioned that her main frustration was over produce packaging, especially organic produce. [Care2 ]

And when it was revealed that Channel Ten was not going to use her as an AFL commentator this season, there were plenty who relished another opportunity to stick the boot in. [Sydney Morning Herald ]

The scoop artist is edlharris, a frequent and often wise commenter in this blog.[Washington Post ]

Commentator Glenn Beck and others have repeatedly drawn parallels between Egypt and the Wisconsin protests. [Christian Science Monitor ]

Now though it has had to be moderated after it was hijacked by commenters who mocked both Natasha and the manner of her death heartlessly. [Telegraph ]

Many fans and NBA commentators have said that we are witnessing a point guard revolution. [Yahoo! Sports ]

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Silica, Amorphous, Manosil

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SILICA, AMORPHOUS

The Regulatory Information fields include information from the U. S. Environmental Protection Agency's Title III Consolidated List of Lists and the U. S. Department of Homeland Security's Chemical Facility Anti-Terrorism Standards (see more about these data sources ).

EPA Consolidated List of Lists

No regulatory information available.

DHS Chemical Facility Anti-Terrorism Standards (CFATS)

No regulatory information available.

Alternate Chemical Names

This section provides a listing of alternate names for this chemical, including trade names and synonyms.

ACTICEL

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CARPLEX CS 5

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CATALOID OSCAL 1432

CATALOID S 20L

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DEP 002

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FILLITE 200/7

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FINESIL B

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FK 320DS

FLORITE 700

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FUJIGEL B

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IMSIL 10

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IMSIL A 10

IMSIL A 108

IMSIL A 108H

IMSIL A 15

IMSIL A 25

IMSIL H

KAOWOOL RIGIDIZER

KESTREL 600

KOMSIL

KS 160

KS 300

KS 380

KS 404

LO-VEL 24

LO-VEL 27

LUDOX

LUDOX 40HS

LUDOX AS 40

LUDOX HS 30

LUDOX HS 40

LUDOX LS

LUDOX RS 40

LUDOX SM

LUDOX TM

LUFILEN E 100

MANOSIL VN 3

MAS 200

MICROSIL

MILOWHITE

MIN-U-SIL

MIN-U-SIL 15

MIN-U-SIL 30

MIN-U-SIL 5

MIZUKASIL

MIZUKASIL NP 8

MIZUKASIL P 526

MIZUKASIL P 527

MIZUKASIL P 73

MIZUKASIL P 78

MIZUKASIL P 78A

MIZUKASIL P 78F

MIZUKASIL P 801

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MIZUKASIL SK 7

MSP-X

NALCAST PLW

NALCO 1034A

NALCO 1115

NALCO 1129

NALCO 1140

NALCO 2SS374

NALCO 8455-258

NALCO 84SS258

NALCO CD 100

NALCOAG 1030

NALCOAG 1034A

NALCOAG 1050

NALCOAG 1060

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NALFLOC N 1030

NALFLOC N 1050

NEOSIL

NEOSIL A

NEOSIL XV

NEOSYL

NEOSYL 186

NEOSYL 224

NEOSYL 81

NEOSYL GP

NIPSIL 300A

NIPSIL AQ

NIPSIL B 220A

NIPSIL E 150

NIPSIL E 150J

NIPSIL E 150K

NIPSIL E 150V

NIPSIL E 200

NIPSIL E 200A

NIPSIL E 220A

NIPSIL ER

NIPSIL ES

NIPSIL G 300

NIPSIL L 300

NIPSIL LP

NIPSIL NA

NIPSIL NS

NIPSIL NST

NIPSIL SS 10

NIPSIL SS 50

NIPSIL SS 50A

NIPSIL VN 3

NIPSIL VN 3AQ

NIPSIL VN3LP

NOVAKUP

NUCLEOSIL 100-5

NYACOL 2034A

OSCAL

OSCAL 1132

OSCAL 1232

OSCAL 1432

OSCAL 1433

OSCAL 1434

P 2

P 2 (SILICA)

PC 100

PHOTOX

PORASIL

POSITIVE SOL 130M

POSITIVE SOL 232

PRECIPITATED AMORPHOUS SILICA

PREGEL

PROTEK-SORB 121

QUSO 51

QUSO G 30

QUSO G 32

QUSO WR 55

QUSO WR 82

REOLOSIL

REOLOSIL 202

REOLOSIL QS 102

ROMSIL

S 1-45D

S 600

S-CO

S-CO (FILLER)

SANTOCEL

SANTOCEL 54

SANTOCEL 62

SANTOCEL CS

SANTOCEL Z

SI-O-LITE

SIDENT 12

SIFLOX

SILANOX 101

SILCRON G 100

SILCRON G 640

SILEX

SILICA

SILICA GEL

SILICA, AMORPHOUS

SILICA, AMORPHOUS HYDRATED

SILICAFILM

SILICALITE

SILICON DIOXIDE

SILICON DIOXIDE (AMORPHOUS)

SILICON DIOXIDE (SIO2)

SILICON OXIDE (SIO2)

SILIKIL

SILIPUR

SILLIKOLLOID

SILMOS

SILNEX NP 8

SILOXID

SILTON A

SILTON A 2

SILTON AK

SILTON LP 75C

SILTON R 2

SIONOX

SIPERNAT 22

SIPUR 1500

SNOWTEX

SNOWTEX 20

SNOWTEX 30

SNOWTEX 40

SNOWTEX AK

SNOWTEX C

SNOWTEX N

SNOWTEX NCS 30

SNOWTEX O

SNOWTEX OL

SNOWTEX OXS

SOLEX (M)

SORBSIL MSG

SOX

SS 10

SS 50

SSA 1

SSK 5

ST 30

ST 30 (MINERAL)

SUPER-CEL

SUPERNAT 22LS

SUPERNAT 250S

SUPERNAT 50S

SX 10

SYLOBLOC 41

SYLOBLOC 44

SYLOBLOC 46

SYLOBLOC 47

SYLODENT 704

SYLOX 15

SYTON

SYTON 2X

SYTON 30X

SYTON FM

SYTON W 15

SYTON W 3

SYTON W 30

SYTON X 30

TARANOX 500

TIX-O-SIL 33J

TIX-O-SIL 375

TIX-O-SIL 38A

TK 900

TMC 200

TOKUSIL AL 1

TOKUSIL GU

TOKUSIL GU-N

TOKUSIL GV-N

TOKUSIL N

TOKUSIL NR

TOKUSIL P

TOKUSIL TPLM

TOKUSIL U

TOKUSIL UR

TOSIL

TOSIL P

TS 100

TS 100 (SILICA)

TULLANOX A 50

TULLANOX TM 500

U 333

ULTRASIL VH 3

ULTRASIL VN 2

ULTRASIL VN 3

ULTRASIL VN 3SP

UNISIL

UNISIL Q 30

VERTICURINE

VITASIL 1500

VITASIL 1600

VITASIL 220

VULKASIL C

VULKASIL S

WESSALON S

WHITE CARBON

XOB 075

ZEO 49

ZEODENT 113

ZEOFREE 80

ZEOPAN

ZEOSIL 1000V

ZEOSIL 175MP

ZEOSIL 75

ZEOSYL 100

ZEOSYL 200

ZEOSYL 2000

ZEOTHIX 265

ZEOTHIX 95

ZIPAX

ZORBAX PSM 1000

ZORBAX PSM 150

ZORBAX PSM 300

ZORBAX PSM 500

ZORBAX PSM 60

ZORBAX SIL

CAMEO Chemicals version 2.7.

Melotec, Melotec

Over the past ten years Myelotec has developed, patented and successfully commercialized its steerable catheter and endoscope technology. Myelotec endoscopic technology enables physicians to diagnose and deliver a drug onto an inflamed nerve root with precision, resulting in less damage to surrounding tissues and minimal impact on the patient’s musculoskeletal structure.

Back pain is the number one medical complaint in the United States today. More than half of all Americans will suffer from back pain during some period of their life, and we currently spend more than $20 billion annually on disability claims, therapy, non-surgical devices and supports, and surgery to treat the pain.

The Myelotec line of interventional pain management devices can relieve debilitating pain with precision, resulting in less damage to surrounding tissues and minimal impact on the patient’s musculoskeletal structure.

The number of degenerative disc procedures in the U. S. and internationally is expected to increase from 1 million in 2005 to 1.7 million in 2008. Myelotec offers a complete line of steerable catheters, fiber optic endoscopes, light guides, and supporting devices which permit physicians to treat back pain with precision, resulting in less damage to surrounding tissues and minimal impact on the patient’s musculoskeletal structure.

Featured Guides

Contact Lens Care

Contact lenses come in many different varieties to address the vision correction needed. Millions of users wear contact lenses now.

Bipolar Disorder

According to World Health Organization, Bipolar disorder is the sixth leading cause of disability in the world.

Type 2 diabetes

Type 2 diabetes is a chronic disease that you and your doctor can manage with the right combination of medication, diet, and exercise.

Top Guides

Contact Lens Care

Contact lenses come in many different varieties to address the vision correction needed. Millions of users wear contact lenses now.

Bipolar Disorder

According to World Health Organization, Bipolar disorder is the sixth leading cause of disability in the world.

Type 2 diabetes

Type 2 diabetes is a chronic disease that you and your doctor can manage with the right combination of medication, diet, and exercise.

Top Guides

License & Identifications

A medical license is required for a doctor to practice medicine in a particular state. Requirements vary by state but most require, at a minimum, post-graduate training in the doctor’s specific specialty. An NPI number is a national identifier unique to an individual health care provider and is managed by the Center for Medicare & Medicaid Services (CMS).

Learn more about Dr. Alan Melotek:

View the full profile to get information on:

Patient Reviews

Patient comments (15)

The overall average patient rating of Dr. Alan Melotek is Good . Dr. Melotek has been reviewed by 31 patients who have provided 15 comments. The rating is 3.5 out of 5 stars.

Editrim, Editrim

Bactrim consists of two medications: sulfamethoxazole and trimethoprim. The first inhibits synthesis of dihydrofolic acid (the substance important for human and bacterial metabolism) while the last blocks next stage of its biochemical cycle: formation of tetrahydrofolic acid which occurs only in microorganisms. This medication is effective against streptococci, staphylococci, pneumococci, bacillus dysentery, typhoid fever, E. coli, Proteus, and ineffective against Mycobacterium tuberculosis, spirochetes, Pseudomonas aeruginosa. Bactrim is applied in treatment of pneumonia and other diseases of respiratory, gastrointestinal systems, urogenital systems caused by bacterial infections which develop after surgery and others.

Dosage and directions

Bactrim can be taken two or three times a day with or without a meal. Dosage depends on the type and severity of infection. Take with a glass of water. Patients with severe kidney failure require correction of Bactrim dosage.

Precautions Avoid exposure to sunlight or getting tanned. Antibiotic medicines can cause diarrhea, inform your doctor if you have it, it can mask other infection. Warn your doctor if you suffer from asthma or have severe kidney or liver disorders.

Contraindications Do not take Bactim if you are allergic to components of the medication, if you are pregnant, breastfeeding, have anemia caused by folic acid deficiency. This medication should not be administered to premature babies and newborns.

Possible side effect

If you have such signs of allergic reaction as hives, difficulty breathing, swelling of your face, lips, tongue, or throat or more serious signs of poor health as fever, sore throat, and headache with a severe blistering, pale skin, easy bruising or bleeding, diarrhea that is watery or bloody, hallucinations, slow heart rate, weak pulse, nausea, stomach pain, urinating less than usual or not at all then seek for immediate medical attention.

Drug interaction Bactim should be co-administered with dofetilide or methenamine. Bactrim is able to change effects of certain anti-diabetic medications, "blood thinners", cyclosporine, digoxin, drugs which can increase potassium levels, live vaccines, tricyclic antidepressants, some "water pills". So inform your doctor about all prescription and nonprescription/herbal products you may use.

Missed dose Never take a double dose of this medication. If it is almost time of the next dose just skip the missed portion and continue to take the medicine according to the schedule.

Overdose If you took too much of Bactim you may feel dizziness, drowsiness, nausea, vomiting, loss of appetite, stomach pain, headache, yellowing of your skin or eyes, blood in your urine, fainting. In case of serious side effects seek for immediate medical help.

Storage Store at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture, kids and pets.

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care advisor or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Bactrim consists of two medications: sulfamethoxazole and trimethoprim. The first inhibits synthesis of dihydrofolic acid (the substance important for human and bacterial metabolism) while the last blocks next stage of its biochemical cycle: formation of tetrahydrofolic acid which occurs only in microorganisms. This medication is effective against streptococci, staphylococci, pneumococci, bacillus dysentery, typhoid fever, E. coli, Proteus, and ineffective against Mycobacterium tuberculosis, spirochetes, Pseudomonas aeruginosa. Bactrim is applied in treatment of pneumonia and other diseases of respiratory, gastrointestinal systems, urogenital systems caused by bacterial infections which develop after surgery and others.

Dosage and directions

Bactrim can be taken two or three times a day with or without a meal. Dosage depends on the type and severity of infection. Take with a glass of water. Patients with severe kidney failure require correction of Bactrim dosage.

Precautions Avoid exposure to sunlight or getting tanned. Antibiotic medicines can cause diarrhea, inform your doctor if you have it, it can mask other infection. Warn your doctor if you suffer from asthma or have severe kidney or liver disorders.

Contraindications Do not take Bactim if you are allergic to components of the medication, if you are pregnant, breastfeeding, have anemia caused by folic acid deficiency. This medication should not be administered to premature babies and newborns.

Possible side effect

If you have such signs of allergic reaction as hives, difficulty breathing, swelling of your face, lips, tongue, or throat or more serious signs of poor health as fever, sore throat, and headache with a severe blistering, pale skin, easy bruising or bleeding, diarrhea that is watery or bloody, hallucinations, slow heart rate, weak pulse, nausea, stomach pain, urinating less than usual or not at all then seek for immediate medical attention.

Drug interaction Bactim should be co-administered with dofetilide or methenamine. Bactrim is able to change effects of certain anti-diabetic medications, "blood thinners", cyclosporine, digoxin, drugs which can increase potassium levels, live vaccines, tricyclic antidepressants, some "water pills". So inform your doctor about all prescription and nonprescription/herbal products you may use.

Missed dose Never take a double dose of this medication. If it is almost time of the next dose just skip the missed portion and continue to take the medicine according to the schedule.

Overdose If you took too much of Bactim you may feel dizziness, drowsiness, nausea, vomiting, loss of appetite, stomach pain, headache, yellowing of your skin or eyes, blood in your urine, fainting. In case of serious side effects seek for immediate medical help.

Storage Store at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture, kids and pets.

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care advisor or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Bactrim consists of two medications: sulfamethoxazole and trimethoprim. The first inhibits synthesis of dihydrofolic acid (the substance important for human and bacterial metabolism) while the last blocks next stage of its biochemical cycle: formation of tetrahydrofolic acid which occurs only in microorganisms. This medication is effective against streptococci, staphylococci, pneumococci, bacillus dysentery, typhoid fever, E. coli, Proteus, and ineffective against Mycobacterium tuberculosis, spirochetes, Pseudomonas aeruginosa. Bactrim is applied in treatment of pneumonia and other diseases of respiratory, gastrointestinal systems, urogenital systems caused by bacterial infections which develop after surgery and others.

Dosage and directions

Bactrim can be taken two or three times a day with or without a meal. Dosage depends on the type and severity of infection. Take with a glass of water. Patients with severe kidney failure require correction of Bactrim dosage.

Precautions Avoid exposure to sunlight or getting tanned. Antibiotic medicines can cause diarrhea, inform your doctor if you have it, it can mask other infection. Warn your doctor if you suffer from asthma or have severe kidney or liver disorders.

Contraindications Do not take Bactim if you are allergic to components of the medication, if you are pregnant, breastfeeding, have anemia caused by folic acid deficiency. This medication should not be administered to premature babies and newborns.

Possible side effect

If you have such signs of allergic reaction as hives, difficulty breathing, swelling of your face, lips, tongue, or throat or more serious signs of poor health as fever, sore throat, and headache with a severe blistering, pale skin, easy bruising or bleeding, diarrhea that is watery or bloody, hallucinations, slow heart rate, weak pulse, nausea, stomach pain, urinating less than usual or not at all then seek for immediate medical attention.

Drug interaction Bactim should be co-administered with dofetilide or methenamine. Bactrim is able to change effects of certain anti-diabetic medications, "blood thinners", cyclosporine, digoxin, drugs which can increase potassium levels, live vaccines, tricyclic antidepressants, some "water pills". So inform your doctor about all prescription and nonprescription/herbal products you may use.

Missed dose Never take a double dose of this medication. If it is almost time of the next dose just skip the missed portion and continue to take the medicine according to the schedule.

Overdose If you took too much of Bactim you may feel dizziness, drowsiness, nausea, vomiting, loss of appetite, stomach pain, headache, yellowing of your skin or eyes, blood in your urine, fainting. In case of serious side effects seek for immediate medical help.

Storage Store at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture, kids and pets.

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care advisor or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Antibiotics - Editrim (Brand name: bactrim)

Bactrim consists of two medications: sulfamethoxazole and trimethoprim. The first inhibits synthesis of dihydrofolic acid (the substance important for human and bacterial metabolism) while the last blocks next stage of its biochemical cycle: formation of tetrahydrofolic acid which occurs only in microorganisms. This medication is effective against streptococci, staphylococci, pneumococci, bacillus dysentery, typhoid fever, E. coli, Proteus, and ineffective against Mycobacterium tuberculosis, spirochetes, Pseudomonas aeruginosa. Bactrim is applied in treatment of pneumonia and other diseases of respiratory, gastrointestinal systems, urogenital systems caused by bacterial infections which develop after surgery and others.

Dosage and directions

Bactrim can be taken two or three times a day with or without a meal. Dosage depends on the type and severity of infection. Take with a glass of water. Patients with severe kidney failure require correction of Bactrim dosage.

Precautions Avoid exposure to sunlight or getting tanned. Antibiotic medicines can cause diarrhea, inform your doctor if you have it, it can mask other infection. Warn your doctor if you suffer from asthma or have severe kidney or liver disorders.

Contraindications Do not take Bactim if you are allergic to components of the medication, if you are pregnant, breastfeeding, have anemia caused by folic acid deficiency. This medication should not be administered to premature babies and newborns.

Possible side effect

If you have such signs of allergic reaction as hives, difficulty breathing, swelling of your face, lips, tongue, or throat or more serious signs of poor health as fever, sore throat, and headache with a severe blistering, pale skin, easy bruising or bleeding, diarrhea that is watery or bloody, hallucinations, slow heart rate, weak pulse, nausea, stomach pain, urinating less than usual or not at all then seek for immediate medical attention.

Drug interaction Bactim should be co-administered with dofetilide or methenamine. Bactrim is able to change effects of certain anti-diabetic medications, "blood thinners", cyclosporine, digoxin, drugs which can increase potassium levels, live vaccines, tricyclic antidepressants, some "water pills". So inform your doctor about all prescription and nonprescription/herbal products you may use.

Missed dose Never take a double dose of this medication. If it is almost time of the next dose just skip the missed portion and continue to take the medicine according to the schedule.

Overdose If you took too much of Bactim you may feel dizziness, drowsiness, nausea, vomiting, loss of appetite, stomach pain, headache, yellowing of your skin or eyes, blood in your urine, fainting. In case of serious side effects seek for immediate medical help.

Storage Store at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture, kids and pets.

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care advisor or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Nisamox Cat Tablets, Nisamox

Bayer Nisamox Tablets For Cats And Dogs

This Item Requires A Prescription From Your Vet.

Nisamox tablets are for the treatment of a range of infections such as skin, urinary tract, enteritis and respiratory in dogs.

Nisamox tablets come in 50mg and 250mg doses and require a veterinary prescription before we can dispense them. Nisamox is indicated for the treatment of a range of infections caused by b-lactamase producing strains of bacteria sensitive to amoxicillin.

Item will be sent once a prescription is received. Prescriptions should be posted to:

Manor House Merlin Way Quarry hill Road Ilkeston Derbyshire DE7 4RA.

Once received, item/s will be dispensed and sent to you. Alternatively the prescription can be faxed to 0115 930 8111. All medicines supplied are UK licensed products.

* We don't sell food to non-UK addresses ** Includes N. Ireland, Scottish Highlands, UK Offshore Islands, Isle of Man, Scilly Isles

UK, Channel Islands, N Ireland, Highlands and Islands - Standard delivery arrives 2-3 days after dispatch or for heavy parcels Courier next day after dispatch Mon-Thu. Europe - Royal Mail International Services or Courier arrives 7-10 days after dispatch.

Express delivery arrives 1-2 days after dispatch or for heavy parcels Courier 1-2 days after dispatch Mon-Thu.

24hr MON-FRI DELIVERY:

Non-Food - Light parcels, delivered Tue-Fri, signature required or for heavy parcels Courier next day Mon-Thu delivery after dispatch^. Food Mainland UK - If ordered before 12pm, next day courier delivery. Food Other UK - Two day courier delivery service.

^ Please note - Items usually dispatched within 24 - 72 hours.

Ailax - Summary Of Salient Adaptive Income Fd Cl A - Mutual Fund Profile, Ailax

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Enzimar, Enzimar

Gastrointestinal - Enzimar (Brand name: metoclopramide)

Metoclopramide is used for short term treatment of gastroesophageal reflux disease (GERD) in certain patients who do not respond to other therapy. It is used to treat symptoms of a certain digestive problem in diabetic patients (diabetic gastroparesis). Metoclopramide is a gastrointestinal stimulant and antinauseant. It works by increasing the movement of the stomach and intestines to help move food and acid out of the stomach more quickly. It also works in certain areas in the brain to decrease nausea.

Use Metoclopramide as directed by your doctor.

Take Metoclopramide by mouth 30 minutes before meals unless directed otherwise by your doctor.

It may take several days to weeks for Metoclopramide to work. Do not stop taking Metoclopramide without checking with your doctor.

If you miss a dose of Metoclopramide, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Metoclopramide.

Store Metoclopramide at room temperature, between 68 and 77 degrees F (20 and 25 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Metoclopramide out of the reach of children and away from pets.

Do NOT use Metoclopramide if:

you are allergic to any ingredient in Metoclopramide

you have seizures (eg, epilepsy); bleeding, blockage, or perforation in your stomach or intestines; or tumors on your adrenal gland (pheochromocytoma)

you are taking cabergoline or pergolide

you are taking medicines, such as phenothiazines (eg, chlorpromazine), that may cause extrapyramidal reactions (abnormal, involuntary muscle movements of the head, neck, or limbs). Check with your doctor if you are unsure if any of your medicines may cause extrapyramidal reactions.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Metoclopramide. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of mental or mood problems (eg, depression) or suicidal thoughts or actions

if you have a history of asthma, heart failure, high blood pressure, diabetes, Parkinson disease, blood problems (eg, porphyria), kidney problems, liver problems (eg, cirrhosis), breast cancer, or low levels of an enzyme called methemoglobin reductase

if you are taking another form of Enzimar (eg, syrup, orally disintegrating tablet).

Some medicines may interact with Metoclopramide. Tell your health care provider if you are taking any other medicines, especially any of the following:

Monoamine oxidase inhibitors (MAOIs) (eg, phenelzine) because the risk of serious side effects (eg, high blood pressure, seizures) may be increased

Anticholinergic medicine (eg, hyoscyamine) or narcotic pain medicines (eg, codeine) because they may decrease Metoclopramide's effectiveness

Acetaminophen, benzodiazepines (eg, diazepam), cyclosporine, insulin, levodopa, phenothiazines (eg, chlorpromazine), sedatives (eg, zolpidem), selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine), succinylcholine, or tetracycline because the risk of their side effects may be increased by Metoclopramide

Cabergoline, digoxin, or pergolide because their effectiveness may be decreased by Metoclopramide.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Metoclopramide may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Metoclopramide may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Metoclopramide with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Metoclopramide without first checking with your doctor; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.

Do NOT take more than the recommended dose or use Metoclopramide for longer than 12 weeks without checking with your doctor.

Diabetes patients - Metoclopramide may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

Tell your doctor or dentist that you take Metoclopramide before you receive any medical or dental care, emergency care, or surgery.

Neuroleptic malignant syndrome (NMS) is a possibly fatal syndrome that can be caused by Metoclopramide. Symptoms may include fever; stiff muscles; confusion; abnormal thinking; fast or irregular heartbeat; and sweating. Contact your doctor at once if you have any of these symptoms.

Some patients who take Metoclopramide may develop muscle movements that they cannot control. This is more likely to happen in elderly patients, especially women. The chance that this will happen or that it will become permanent is greater in those who take Metoclopramide in higher doses or for a long time. Muscle problems may also occur after short-term treatment with low doses. Tell your doctor at once if you have muscle problems with your arms; legs; or your tongue, face, mouth, or jaw (eg, tongue sticking out, puffing of cheeks, mouth puckering, chewing movements) while taking Metoclopramide.

Patients who take Metoclopramide may be at increased risk for new or worsening mental or mood changes (eg, depression) or suicidal thoughts or actions. Watch patients who take Metoclopramide closely. Contact the doctor at once if new, worsened, or sudden symptoms such as depressed mood or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur.

Metoclopramide may increase the amount of a certain hormone (prolactin) in your blood. Symptoms may include enlarged breasts, missed menstrual period, decreased sexual ability, or nipple discharge. Contact your doctor right away if you experience any of these symptoms.

Lab tests, including liver and kidney function tests, may be performed while you use Metoclopramide. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Metoclopramide with caution in the elderly; they may be more sensitive to its effects, especially drowsiness, confusion, and uncontrolled muscle movements, including tardive dyskinesia.

Metoclopramide should be used with extreme caution in children; safety and effectiveness in children have not been confirmed. The risk of developing uncontrolled muscle movements may be greater in children.

Pregnancy and breast feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Metoclopramide while you are pregnant. Metoclopramide is found in breast milk. If you are or will be breast-feeding while you use Metoclopramide, check with your doctor. Discuss any possible risks to your baby.

A small number of patients have experienced withdrawal symptoms when stopping Metoclopramide. These symptoms may include dizziness, nervousness, and headache.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Decreased energy; diarrhea; dizziness; drowsiness; headache; nausea; restlessness; tiredness; trouble sleeping.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); abnormal thinking; confusion; dark urine; decreased balance or coordination; decreased sexual ability; fast, slow, or irregular heartbeat; fever; hallucinations; loss of bladder control; mental or mood changes (eg, depression, anxiety, agitation, jitteriness); seizures; severe or persistent dizziness, headache, or trouble sleeping; severe or persistent restlessness, including inability to sit still; shortness of breath; stiff or rigid muscles; sudden increased sweating; sudden, unusual weight gain; suicidal thoughts or actions; swelling of the arms, legs, or feet; uncontrolled muscle spasms or movements (eg, of the arms, legs, tongue, jaw, cheeks; twitching; tremors); vision changes; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Nichoflam, Nichoflam

Diclofenac is used to treat pain or inflammation caused by arthritis or ankylosing spondylitis. Diclofenac may also be used for purposes other than those listed in this medication guide.

Use Diclofenac as directed by your doctor.

Take Diclofenac by mouth with or without food. Ask your health care provider any questions you may have about how to use Diclofenac.

Drug Class and Mechanism

Diclofenac is in a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Diclofenac works by reducing hormones that cause inflammation and pain in the body.

If you miss a dose of Diclofenac, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Store Diclofenac at room temperature between 68 and 77 degrees F (20 and 25 degrees C) in a tightly closed container. Brief periods at temperatures of 59 to 86 degrees F (15 to 30 degrees C) are permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Diclofenac out of the reach of children and away from pets.

Do not use Diclofenac if:

you are allergic to any ingredient in Diclofenac; you have had a severe allergic reaction (e. g. severe rash, hives, breathing difficulties, dizziness) to another NSAID (e. g. ibuprofen, naproxen, celecoxib) or aspirin. Contact your doctor or health care provider right away if any of these apply to you.

Important : Diclofenac may cause dizziness or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Diclofenac with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it. Before you start any new medicine, check the label to see if it has Nichoflam or another nonsteroidal anti-inflammatory drug (NSAID) medicine in it too. If it does or if you are not sure, check with your doctor or pharmacist. Diclofenac should not be used in children; safety and effectiveness in children have not been confirmed. Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Diclofenac while you are pregnant. It is not known if Diclofenac is found in breast milk. Do not breast-feed while using Diclofenac.

Possible Side Effects

Check with your doctor if any of these most common side effects persist or become bothersome:

burning or stinging; discharge; eye redness, irritation, or itching. Seek medical attention right away if any of these severe side effects occur:

severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred or distorted vision; eye infection; eyelid swelling or redness; sensitivity to glare or light.

Diclofenac is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor.

Turbovas Tablet Micro Labs Use, Composition, Dosage, Side Effect, Price And Review - Tablet Tree, Tu

Turbovas

Turbovas Tablets - Uses, Composition, Dosage, Side Effects and Reviews

High cholesterol is quite prevalent among the people globally nowadays. It may be due to lack of physical activity and improper diet containing lot of fats. It is life threatening and can lead to stroke, heart attack and other heart problems if it is left untreated. Although this problem is curable with lot of medicines available in the market but these drugs have great side effects which can not be tolerated by the cholesterol patients. These patients need such a drug which can cure hypercholesterolemia effectively and with few side effects. Keeping in mind the requirements of patients, Turbovas has been launched in the market to give patients a faster recovery by not only curing hypercholesterolemia but also hyperlipidemia in which these is high level of lipids thus lowering their chances of heart attacks and strokes with very few side effects bothering them. It contains rosuvastatin as its active ingredient which belongs to a class of drugs called statins.

Now stop worrying about the problem of high cholesterols by using this medicine regularly as prescribed by your physician. Buy Turbovas online at discounted prices at Tablet tree.

Turbovas Tablets Uses

It contains rosuvastatin as its active ingredient. It belongs to a class of drugs called statins. It works by inhibiting the enzyme HMG-CoA reductase which further slows down the rate of producing mevalonate which is a molecule formed to produce cholesterol. As 80% of cholesterol is synthesized by liver, thus it inhibits the cholesterol synthesis by the liver.

Turbovas Tablets Composition

Turbovas Tablets Dosage

Consult your physician or doctor for the exact dose and duration. The recommended initial dose is 10 mg once daily. Please consult your doctor and follow his or her recommendations. Please do not self medicate.

Turbovas Tablets Side Effects

The common side effects which can occur after taking this medicine are:

Asthenia Insomnia

Dizziness Depression

Rash Proteinuria

Paraesthesia Rhabdomyolysis

Headache Constipation

Nausea Vomiting

Abdominal pain Myalgia

Chest pain Peripheral oedema

Consult your physician if any of these side effects bother you.

Other Information on Turbovas Tablets:

Pharmaceutical Form

Precautions

Read these precautions carefully before taking this medicine:

It may cause jaundice

Discontinue this drug:

if elevations in the serum transaminases persist

significant increase in creatinine phosphokinase

evidence of myopathy

Use this drug cautiously in case of renal impairment Control hypercholesterolemia while using this medicine

Drug-Drug Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This drug interacts with the following drugs:

Gemfibrozil Cimetidine

Fenofibrate Ketoconazole

Niacin Clofibrate

Spironolactone Alcohol

Mylanta Eluxadoline

Clopidogrel Atazanavir

Ritonavir Lopinavir

Cyclosporine Maalox

Warfarin

Overdose

An overdose of a drug may be accidental or intentional. The person may get his dose wrong or misread the label. Symptoms . Chest tightness blue or grey skin colour, fever, itching, seizures or swelling of face, lips, tongue, wheezing, bad cough, bad muscle pain or weakness, any bruising or bleeding, flu-like signs, dark urine or yellow skin or eyes. Management . Call your local poison control center right away or seek medical help immediately

Contraindications

This medicine is not recommended in these conditions:

Hypersensitivity to any component of the drug

Active liver disease

Elevations of serum transaminases

Storage

Store below 30°C. Keep it out from the reach of children and pets.

Manufacturer

Micro Labs Limited

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Disclaimer: In compliance with the Indian Government's Drug and Cosmetic Act and Rules, we do not process requests for Schedule X and other habit forming drugs. For Schedule H and H1 drugs, you will need to upload a valid prescription from a registered medical practitioner before we can process your order.

The information contained on this page is only an educational aid. This information does not intend to be medical advice for individual conditions or treatment. Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. This information is not a substitute for a medical exam, doctor visit or any services provided by medical or healing professionals. Only your doctor can provide you safe and effective advice based on your own physical conditions or symptoms. The use of the www. tablettree. com is at your risk. These products or information are provided as-is and without any warranties of any kind, either expressed or implied. www. tablettree. com makes no representation or warranty to the accuracy or completeness of any of the information. www. tablettree. com makes no warranties to the opinions or services or data that you may access as a result of using our website. All implied warranties are hereby excluded. www. tablettree. com does not assume any responsibility or risk for your use of www. tablettree. com.

Nifeslow, Nifeslow

Product Description Common use Prednisone is a corticosteroid used to reduce inflammation and alleviate symptoms in a variety of disorders, including rheumatoid arthritis and severe cases of asthma. Prednisone decreases or prevents tissues from responding to inflammation and also modifies the body's response to certain immune stimulation.

Dosage and direction Take it orally with or without food (it's recommended that prednisone be taken with food). Commonly used dosage is various from 5 to 60 mg per day and often is adjusted based on the response of the condition being treated. Corticosteroids should be used for several days for best result. Prolonged therapy with this drug causes the adrenal glands to atrophy and stop producing cortisol, so when Prednisone is discontinued after a period of prolonged therapy, the dose of Prednisone must be tapered to allow the adrenal glands time to recover. Note: this instruction presented here just for review. It's very necessary to consult your doctor before using. It will help you to get the best results.

Precautions You should not start taking Prednisone if you are suffering from a severe bacterial, fungal or viral infection. Do not use this drug without doctor's permission if your medical history includes: kidney disease, a psychiatric condition, heart disease or high blood pressure, liver disease, Diverticulitis, Ulcerative Colitis, or stomach ulcers, hypothyroidism, diabetes mellitus, Myasthenia gravis, osteoporosis or any other medical disorders. Do not stop taking Prednisone suddenly because your own adrenal glands cannot quickly produce enough cortisone. Also note that this drug increases appetite! So you must control your meal. Use caution in children because Prednisone can affect growth. Prednisone should not be used during pregnancy, becoming pregnant or lactating without doctor's advice. Do not use before breast-feeding without doctor's advice.

Contraindications Prednisone is not allowed to people who are hypersensitive to any components of this medicine. Also Prednisone contraindicated in the presence of infections, especially tuberculosis, fungal infectons, amebiasis, vaccinia and varicella, and antibiotic-resistant infections; lactation.

Possible side effect They may include all types of an allergic reaction. Also the most serious side effects include: problems with your vision; swelling, rapid weight gain, feeling short of breath; severe depression, unusual thoughts or behavior, seizure; bloody or tarry stools, coughing up blood; pancreatitis; low potassium; dangerously high blood pressure. Less serious include: sleep problems, mood changes; acne, dry skin, thinning skin, bruising or discoloration; slow wound healing; increased sweating; headache, dizziness, spinning sensation; nausea, stomach pain, bloating; changes in the shape or location of body fat. If you experience one of them stop using Prednisone and tell your doctor as soon as possible. Also consult with your doctor about any side effect that seems unusual.

Drug interaction Prednisine interacts with the following dugs: aspirin; a diuretic; a blood thinner such as warfarin; cyclosporine; insulin or diabetes medications you take by mouth; ketoconazole; rifampin; seizure medications such as phenytoin or phenobarbital. Also note that interaction between two medications does not always mean that you must stop taking one of them. As usual it affects the the effect of drugs, so consult with your doctor about how it interactions are being managed or should be managed.

Missed dose If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or almost time for your next dose. Do not increase your recommended dose. Take your usually dose next day in the same regularly time.

Overdose Symptoms of Prednisone overdose may include thinning skin, easy bruising, changes in the shape or location of body fat, increased acne or facial hair, menstrual problems, impotence, or loss of interest in sex. If you experience one of them or any unusual symptoms call your doctor immediately.

Storage Store at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture, kids and pets. Do not use after expiration term.

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Omepirex, Omepirex

Product Description Common use This medicine is a proton pump inhibitor (PPI) used to treat ulcers, heartburn, gastroesophageal reflux, erosive esophagitis, or Zollinger-Ellison syndrome and also ulcers generated by long-term use of non-steroidal anti-inflammatory drugs (NSAIDs). To treat ulcers caused by bacterial infections this medicine may be used in combination with antibiotics such as amoxicillin or clarithromycin. Prilosek significantly alleviates such their symptoms as heartburn, difficulty swallowing, coughing, and sleep problems. Prilosek works by blocking acid production in the stomach. The medicine may be used to treat other conditions diagnosed by your doctor.

Dosage and directions Follow all the directions provided by your doctor. Take this medication (15-30 mg) orally once a day in morning before a meal with a full glass of water or according to your doctor's recommendations. Swallow the tab whole, do not chew, crush, or open the capsule as may destroy the drug and/or increase side effects. Antacids drugs can be taken together with this medicine, if necessary. Dosage and duration of treatment depends on your medical condition and response to the therapy. Take it the same time each day to avoid missing a dose. In the case of aggravation or worsening of your illness notify your doctor immediately. It may take 1 - 4 days before Prilosek acts in full measure. Treatment with Prilosec should not be stopped even if certain amelioration is achieved. Improvement of symptoms is observed within 4 to 8 weeks in treatment of gastric ulcers or reflux disease. Treatment of heartburn usually lasts for 14 days. If heartburn persists after this period of time or even worsens, or if you need more than one course of treatment every 4 months, contact your doctor or pharmacist.

Precautions Prilosec is not recommended during pregnancy. Breastfeeding when using this drug is not recommended as it is not known whether it gets into breast milk. Tell your doctor if allergic reaction appears. Your doctor or pharmacist should be aware of your health problems, to provide health care, especially if you have problems such as liver disease, other stomach problems (e. g. tumors), heartburn over 3 months, unexplained weight loss, constant nausea/vomiting /stomach pain, blood in vomit or black stools. Some symptoms may witness about a more serious condition. This medicine may cause dizziness. Be careful performing work associated with concentration of attention, such as driving or operating mechanisms. Restrict consumption of alcoholic beverages. Start or interruption in taking any medicine should be be approved by your doctor. If you do not notice any improvement of your symptoms or if they even become worse, inform your doctor about it. Do not share this medicine with anybody with similar symptoms. Do not use this medicine to treat other diseases.

Possible side effects Adverse reactions that may disappear during treatment include headache, constipation, cough, dizziness, or rash. If they continue or are bothersome, let your doctor know about it. An allergic reaction to this medicine is not expected, but seek immediate medical help if it happens. Symptoms of an allergic reaction appear as rash, itching, dizziness, swelling, or difficult breathing. If you notice other reactions of your body which are not listed above, contact your doctor or pharmacist.

Prilosec can decreases elimination of diazepam, warfarin and phenytoin. These are medications metabolized in the liver by oxidation. Drugs which are metabolized with help of cytochrome P-450 system (e. g. cyclosporine, disulfiram, benzodiazepines) may also interact with Prilosec because it is metabolized the same way. Clarithromycin is also metabolized by cytochrome P450, concomitant administration of clarithromycin with Prilosec may result in increases in plasma levels of Prilosec. Concomitant use of Prilosec and clarithromycin may result in increases in plasma levels of erithromycin, and 14-hydroxy-clarithromycin. You may need additional monitoring of your condition if you are taking ampicillin, cilostazol, cyclosporine, diazepam, digoxin, disulfiram, iron, itraconazole, ketoconazole, moclobemide, phenytoin, sucralfate, vorconizole, or warfarin. This medicine may be combined with antacids if they were prescribed by your doctor. Potent acid-reducing drugs such as Prilosec diminish the effectiveness of sucralfate, and other medicaitons such as the antifungals ketoconazole and itraconazole. If instructed to take any of these medicines while taking Prilosec, consult your doctor or pharmacist regarding the proper timing of each dose, usually Prilosec is taken 30 minutes before sucralfate.

Missed dose If you missed a dose take the medication as soon as you remember. If it is almost time of your next dose, just skip its intake and return to your regular schedule.

Overdose If suppose that took too much of Prilosec contact your local poison control center or emergency room immediately. Symptoms of overdose are confusion, blurred vision, unusual sweating, or unusually fast heartbeat.

Storage Store at room temperature between 59-77 F (15-25 C). Do not expose to high humidity or keep in a bathroom. Hide Prilosec away from children and pets. If your treatment requires an extended period of time, take care about refills before your supply is over.

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

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Zenpro (Omeprazole)

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© Quintiles 2016

Product Description Common use This medicine is a proton pump inhibitor (PPI) used to treat ulcers, heartburn, gastroesophageal reflux, erosive esophagitis, or Zollinger-Ellison syndrome and also ulcers generated by long-term use of non-steroidal anti-inflammatory drugs (NSAIDs). To treat ulcers caused by bacterial infections this medicine may be used in combination with antibiotics such as amoxicillin or clarithromycin. Prilosek significantly alleviates such their symptoms as heartburn, difficulty swallowing, coughing, and sleep problems. Prilosek works by blocking acid production in the stomach. The medicine may be used to treat other conditions diagnosed by your doctor.

Dosage and directions Follow all the directions provided by your doctor. Take this medication (15-30 mg) orally once a day in morning before a meal with a full glass of water or according to your doctor's recommendations. Swallow the tab whole, do not chew, crush, or open the capsule as may destroy the drug and/or increase side effects. Antacids drugs can be taken together with this medicine, if necessary. Dosage and duration of treatment depends on your medical condition and response to the therapy. Take it the same time each day to avoid missing a dose. In the case of aggravation or worsening of your illness notify your doctor immediately. It may take 1 - 4 days before Prilosek acts in full measure. Treatment with Prilosec should not be stopped even if certain amelioration is achieved. Improvement of symptoms is observed within 4 to 8 weeks in treatment of gastric ulcers or reflux disease. Treatment of heartburn usually lasts for 14 days. If heartburn persists after this period of time or even worsens, or if you need more than one course of treatment every 4 months, contact your doctor or pharmacist.

Precautions Prilosec is not recommended during pregnancy. Breastfeeding when using this drug is not recommended as it is not known whether it gets into breast milk. Tell your doctor if allergic reaction appears. Your doctor or pharmacist should be aware of your health problems, to provide health care, especially if you have problems such as liver disease, other stomach problems (e. g. tumors), heartburn over 3 months, unexplained weight loss, constant nausea/vomiting /stomach pain, blood in vomit or black stools. Some symptoms may witness about a more serious condition. This medicine may cause dizziness. Be careful performing work associated with concentration of attention, such as driving or operating mechanisms. Restrict consumption of alcoholic beverages. Start or interruption in taking any medicine should be be approved by your doctor. If you do not notice any improvement of your symptoms or if they even become worse, inform your doctor about it. Do not share this medicine with anybody with similar symptoms. Do not use this medicine to treat other diseases.

Possible side effects Adverse reactions that may disappear during treatment include headache, constipation, cough, dizziness, or rash. If they continue or are bothersome, let your doctor know about it. An allergic reaction to this medicine is not expected, but seek immediate medical help if it happens. Symptoms of an allergic reaction appear as rash, itching, dizziness, swelling, or difficult breathing. If you notice other reactions of your body which are not listed above, contact your doctor or pharmacist.

Prilosec can decreases elimination of diazepam, warfarin and phenytoin. These are medications metabolized in the liver by oxidation. Drugs which are metabolized with help of cytochrome P-450 system (e. g. cyclosporine, disulfiram, benzodiazepines) may also interact with Prilosec because it is metabolized the same way. Clarithromycin is also metabolized by cytochrome P450, concomitant administration of clarithromycin with Prilosec may result in increases in plasma levels of Prilosec. Concomitant use of Prilosec and clarithromycin may result in increases in plasma levels of erithromycin, and 14-hydroxy-clarithromycin. You may need additional monitoring of your condition if you are taking ampicillin, cilostazol, cyclosporine, diazepam, digoxin, disulfiram, iron, itraconazole, ketoconazole, moclobemide, phenytoin, sucralfate, vorconizole, or warfarin. This medicine may be combined with antacids if they were prescribed by your doctor. Potent acid-reducing drugs such as Prilosec diminish the effectiveness of sucralfate, and other medicaitons such as the antifungals ketoconazole and itraconazole. If instructed to take any of these medicines while taking Prilosec, consult your doctor or pharmacist regarding the proper timing of each dose, usually Prilosec is taken 30 minutes before sucralfate.

Missed dose If you missed a dose take the medication as soon as you remember. If it is almost time of your next dose, just skip its intake and return to your regular schedule.

Overdose If suppose that took too much of Prilosec contact your local poison control center or emergency room immediately. Symptoms of overdose are confusion, blurred vision, unusual sweating, or unusually fast heartbeat.

Storage Store at room temperature between 59-77 F (15-25 C). Do not expose to high humidity or keep in a bathroom. Hide Prilosec away from children and pets. If your treatment requires an extended period of time, take care about refills before your supply is over.

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Vetrocloricin, Vetrocloricin

Chloramphenicol

Click for further information on drug naming conventions and International Nonproprietary Names .

Important Notice: The Drugs. com international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

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Chloramphenicol (Vetrocloricin)

Chloramphenicol is used for treating serious infections caused by certain bacteria. Chloramphenicol is an antibiotic. It works by killing or slowing the growth of sensitive bacteria.

Use Chloramphenicol as directed by your doctor.

Take Chloramphenicol by mouth with or without food.

If you miss a dose of Chloramphenicol, use it as soon as possible. Then use your doses at evenly spaced times as directed by your doctor. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Chloramphenicol.

Store Chloramphenicol at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Keep Chloramphenicol out of the reach of children and away from pets.

Do NOT use Chloramphenicol if:

you are allergic to any ingredient in Chloramphenicol

you have previously had serious side effects from Chloramphenicol

you have a low white or red blood cell count or decreased blood platelets

you have a minor infection such as a cold, flu, throat infection, or you are using Chloramphenicol to prevent a bacterial infection

you are taking other medicines that may decrease your bone marrow (eg, cancer chemotherapy); check with your doctor or pharmacist if you are unsure if any of your other medicines may decrease your bone marrow.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Chloramphenicol. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have anemia, bone marrow problems, liver disease, or kidney problems.

Some medicines may interact with Chloramphenicol. Tell your health care provider if you are taking any other medicines, especially any of the following:

Anticoagulants (eg, warfarin) because side effects, including risk of bleeding, may be increased

Hydantoins (eg, phenytoin) or sulfonylureas (eg, glyburide) because the actions and side effects of these medicines may be increased.

Medicines that may decrease your bone marrow (eg, cancer chemotherapy ) because the risk of serious side effects, such as low blood platelet levels and low white blood cell counts, may be increased; check with your doctor or pharmacist if you are unsure if any of your medicines may decrease your bone marrow.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Chloramphenicol may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Do not exceed the recommended dose or use Chloramphenicol for longer than prescribed without checking with your doctor.

Chloramphenicol is effective only against bacteria. It is not effective for treating viral infections (eg, the common cold).

It is important to use Chloramphenicol for the full course of treatment. Failure to do so may decrease the effectiveness of Chloramphenicol and increase the risk that the bacteria will no longer be sensitive to Chloramphenicol and will not be able to be treated by this or certain other antibiotics in the future.

Long-term or repeated use of Chloramphenicol may cause a second infection. Your doctor may want to change your medicine to treat the second infection. Contact your doctor if signs of a second infection occur.

If symptoms of "gray syndrome" (swelling of the abdomen, pale or blue skin color, vomiting, shock, difficulty breathing, refusal to suck, loose green stools, limp muscles, low temperature) occur in a newborn or infant, contact your doctor. Death may occur within hours of the onset of symptoms. Stopping use of Chloramphenicol when symptoms first appear increases the chance for a complete recovery.

Chloramphenicol may lower your body's ability to fight infection. Prevent infection by avoiding contact with people with colds or other infections. Notify your doctor of any signs of infection, including fever, sore throat, rash, or chills.

Chloramphenicol may reduce the number of clot-forming cells (platelets) in your blood. To prevent bleeding, avoid situations in which bruising or injury may occur. Report any unusual bleeding, bruising, blood in stools, or dark, tarry stools to your doctor.

Diabetes patients - Chloramphenicol may affect your blood sugar. Check blood sugar levels closely and ask your doctor before adjusting the dose of your diabetes medicine.

LAB TESTS, including complete blood cell counts, may be performed to monitor your progress or check for side effects. Be sure to keep all doctor and lab appointments.

Use Chloramphenicol with extreme caution in children younger 1 year. Safety and effectiveness in this age group have not been confirmed.

Use Chloramphenicol with extreme caution in children younger 10 years who have diarrhea or a stomach or bowel infection.

Use Chloramphenicol with extreme caution in premature and full-term infants because they may be more sensitive to the effects of Chloramphenicol, especially the risk of "gray syndrome."

Pregnancy and breast-feeding: If you become pregnant while taking Chloramphenicol, discuss with your doctor the benefits and risks of using Chloramphenicol during pregnancy. Chloramphenicol should be used with extreme caution during full-term pregnancy and labor because the fetus may experience severe side effects. Chloramphenicol is excreted in breast milk. Do not breastfeed while taking Chloramphenicol.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Mild diarrhea, nausea, or vomiting.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; dark urine; delirium; depression; headache; fever, chills, or sore throat; pain, redness, or swelling at the injection site; symptoms of "gray syndrome" in an infant (swelling of the abdomen, pale or blue skin color, vomiting, shock, difficulty breathing, refusal to suck, loose green stools, limp muscles, low temperature); unusual bleeding or bruising; unusual tiredness; vision changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Imigran Tablets 100 Mg, Amigren

IMIGRAN TABLETS 100 MG

Transcript

Package Leaflet: Information for the User

What is in this leaflet 1 What Imigran is and what it is used for 2 What you need to know before you use Imigran 3 How to use Imigran sumatriptan

50 mg or 100 mg tablets

Read all of this leaflet carefully before you start taking this medicine because it contains important information for you. • Keep this leaflet. You may need to read it again. • If you have any further questions, ask your doctor or pharmacist. • This medicine has been prescribed for you only. Do not pass it on to others - it may harm them, even if their signs of illness are the same as yours. • If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

4 Possible side effects 5 How to store Imigran 6 Contents of the pack and other information

1 What Imigran is and what it is used for

Each Imigran capsule-shaped tablet contains a single dose of sumatriptan, which belongs to a group of medicines called triptans (also known as 5-HT1 receptor agonists). Imigran is used to treat migraine headache. Migraine symptoms may be caused by the temporary widening of blood vessels in the head. Imigran is believed to reduce the widening of these blood vessels. This in turn helps to take away the headache and relieve other symptoms of a migraine attack, such as feeling or being sick (nausea or vomiting) and sensitivity to light and sound.

hat you need to know before 2W you use Imigran Don’t use Imigran:

• If you’re allergic to sumatriptan, or any of

the other ingredients of this medicine (listed in section 6) • If you have a heart problem such as narrowing of the arteries (Ischaemic heart disease) or chest pains (angina), or have already had a heart attack • If you have circulation problems in your legs that cause cramp-like pains when you walk (peripheral vascular disease)

• If you have had a stroke or a mini-stroke (also called a transient ischaemic attack or TIA)

• If you have high blood pressure. You may

be able to use Imigran if your high blood pressure is mild and is being treated • If you have serious liver disease • With other migraine medicines, including those which contain ergotamine, or similar medicines such as methysergide maleate; or any triptan or 5-HT1 agonist (such as naratriptan or zolmitriptan)

With any of the following anti-depressants: • • MAOIs (monoamine oxidase inhibitors) or if you have taken an MAOI in the last 2 weeks • SSRIs (selective serotonin reuptake inhibitors) including citalopram, fluoxetine, fluvoxamine, paroxetine and sertaline • SNRIs (serotonin noradrenaline reuptake inhibitors) including venlafaxine and duloxetine

F or • children under 18 years of age. If any of these apply to you:

• If you are a woman who has been through

the menopause. In very rare cases, people have developed serious heart conditions after using Imigran, even though they had no signs of heart disease before. If any of the points above applies to you it could mean you have a greater risk of developing heart disease - so:

? Tell your doctor so that your heart function

can be checked before Imigran is prescribed for you.

If you have a history of fits (seizures) Or if you have other conditions which might make it more likely that you’ll have a fit - for example, a head injury or alcoholism:

? Tell your doctor so that you can be supervised more closely.

If you have had high blood pressure Imigran may not be suitable for you

? Tell your doctor or pharmacist before using Imigran.

? Tell your doctor, and don’t use Imigran

If you have liver or kidney disease If either of these apply to you:

Take special care with Imigran

? Tell your doctor or pharmacist before using

Talk to your doctor or pharmacist before using Imigran.

If you have an intolerance to some sugars

If you have any extra risk factors • If you are a heavy smoker, or using nicotine replacement therapy, and especially • If you are a man aged over 40, or

? Tell your doctor so that you can be supervised more closely.

If you are allergic to antibiotics called sulphonamides If so, you may also be allergic to Imigran. If you know you are allergic to an antibiotic but you are not sure whether it is a sulphonamide:

? Tell your doctor or pharmacist before using Imigran.

If you are taking anti-depressants called SSRIs (Selective Serotonin Reuptake Inhibitors) or SNRIs (Serotonin Noradrenaline Reuptake Inhibitors)

? Tell your doctor or pharmacist before using Imigran. Also see Other medicines and Imigran, below.

If you use Imigran frequently. Using Imigran too often may make your headaches worse.

? Tell your doctor if this applies to you. He or she may recommend you stop using Imigran.

If you feel pain or tightness in your chest after you use Imigran These effects may be intense but they usually pass quickly. If they don’t pass quickly, or they become severe:

? Get medical help immediately. Section 4 (overleaf) has more information about these possible side effects.

Other medicines and Imigran Tell your doctor or pharmacist if you’re taking, have recently taken or might take any other medicines. This includes any herbal products or medicines you’ve bought without a prescription. Some medicines must not be taken with Imigran and others may cause adverse effects if they’re taken with Imigran. You must tell your doctor if you are taking: • ergotamine also used to treat migraine, or similar medicines such as methysergide (see section 2 Don’t use Imigran). Don’t use Imigran at the same time as these medicines. Stop taking these medicines at least 24 hours before using Imigran. Don’t take any medicines which contain ergotamine or compounds similar to ergotamine again for at least 6 hours after using Imigran. • other triptans/5-HT1 receptor agonists (such as naratriptan, rizatriptan, zolmitriptan), also used to treat migraine, (see section 2 Don’t use Imigran). Don’t use Imigran at the same time as these medicines. Stop taking these medicines at least 24 hours before using Imigran. Don’t take another triptan/5-HT1 receptor agonist again for at least 24 hours after using Imigran. • MAOIs used to treat depression. Don’t use Imigran if you have taken these in the last 2 weeks.

• SSRIs and SNRIs used to treat depression.

Using Imigran with these medicines can cause serotonin syndrome (a collection of symptoms which can include restlessness, confusion, sweating, hallucinations, increased reflexes, muscle spasms, shivering, increased heartbeat and shaking). Tell your doctor immediately if you are affected in this way. • St John’s Wort (Hypericum perforatum). Taking herbal remedies that contain St John’s Wort together with Imigran may make side effects more likely.

GSK-POL-Poznan-PLPZN United Kingdom-GBR Imigran

Pregnancy and breast-feeding

• If you are pregnant, think you may be

pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine. There is only limited information about the safety of Imigran for pregnant women, though up till now there is no evidence of any increased risk of birth defects. Your doctor will discuss with you whether or not you should use Imigran while you are pregnant

• Don’t breast-feed your baby for 12 hours after using Imigran. If you express any breast milk during this time, discard the milk and don’t give it to your baby.

Driving and using machines Either the symptoms of migraine or your medicine may make you drowsy. If you are affected, don’t drive or operate machinery.

Poznan – Additional Artwork Information Panel Leaflet / dimensions after folding

Point of sale code No.:

Leading: 9.3pt Horizontal Scale: 85% Smallest text size: 8.0pt Microtext: No

Always take this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure.

When to take Imigran

• It’s best to take Imigran as soon as you feel a migraine coming on, although - you can take it at any time during an attack

• Don’t use Imigran to try to prevent an attack - only use it after your migraine symptoms start.

How much to take Adults aged 18 to 65 • The usual dose for adults aged 18 to 65 is one Imigran 50 mg tablet, swallowed whole with water. Some patients may need a 100 mg dose - you should follow your doctor’s advice. Children under 18

• Imigran is not recommended for children under 18 years old.

Elderly (aged over 65)

• Imigran is not recommended for people aged over 65.

If your symptoms start to come back

• You can take a second Imigran tablet if at least 2 hours have passed since the first tablet. Don’t take more than 300 mg in total in 24 hours.

5 How to store Imigran

3 How to use Imigran If the first tablet has no effect

• Don’t take a second tablet or any other Imigran preparation for the same attack. Imigran can still be used for your next attack. If Imigran doesn’t give you any relief: ? Ask your doctor or pharmacist for advice. If you take more Imigran than you should

• Don’t take more than six 50 mg tablets or

three 100 mg tablets (300 mg in total) in any 24 hours. Taking too much Imigran could make you ill. If you have taken more than 300 mg in 24 hours:

? Contact your doctor for advice. If you have any further questions about the use of this medicine, ask your doctor or pharmacist.

4 Possible side effects Like all medicines, this medicine can cause side effects, but not everybody gets them. Some symptoms may be caused by the migraine itself. Allergic reaction: get doctor’s help straight away The following side effects have occurred but their exact frequency is not known. • The signs of allergy include rash, hives (itchy rash); wheezing; swollen eyelids, face or lips; complete collapse.

If you get any of these symptoms soon after using Imigran:

? Don’t use any more. Contact a doctor straight away.

Common side effects (affect up to 1 in 10 people) • Pain, heaviness, pressure or tightness in the chest, throat or other parts of the body, or unusual sensations, including numbness, tingling and warmth or cold. These effects may be intense but generally pass quickly. If these effects continue or become severe (especially the chest pain):

? Get medical help urgently. In a very small

number of people these symptoms can be caused by a heart attack.

Other common side effects include:

(vomiting), although this may be due to the migraine itself Tiredness or drowsiness Dizziness, feeling weak, or getting hot flushes Temporary increase in blood pressure Shortness of breath Aching muscles.

Very rare side effects (affect up to 1 in 10,000 people) • Liver function changes. If you have a blood test to check your liver function, tell your doctor or nurse that you are taking Imigran.

Some patients may get the following side effects but it is not known how often they occur • Seizures/fits, tremors, muscle spasm, neck stiffness • Visual disturbances such as flickering, reduced vision, double vision, loss of vision, and in some cases even permanent defects (although these may be due to the migraine attack itself)

• Heart problems, where your heartbeat may go faster, slower or change rhythm, chest pains (angina) or heart attack • Pale, blue-tinged skin and/or pain in your fingers, toes, ears, nose or jaw in response to cold or stress (Raynaud’s phenomenon)

• Feeling faint (blood pressure may go down) • Pain in the lower left side of the stomach and bloody diarrhoea (ischaemic colitis) • Diarrhoea • Pain in the joints • Feeling anxious • Excessive sweating Reporting of side effects If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www. mhra. gov. uk/yellowcard By reporting side effects you can help provide more information on the safety of this medicine.

Keep this medicine out of the sight and reach of children. Do not use this medicine after the expiry date shown on the carton. The expiry date refers to the last day of that month. Store below 30°C. Don’t throw away any medicines via waste water or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.

6 Contents of the pack and other information

What Imigran contains

• The active substance is sumatriptan (50 mg

Marketing authorisation holder and manufacturer Product Licence held by Glaxo Wellcome UK Ltd. Stockley Park West, Uxbridge, Middlesex UB11 1BT Manufactured by GlaxoSmithKline Pharmaceuticals S. A. ul. Grunwaldzka 189, 60-322 Poznan, Poland The information provided applies only to Imigran tablets.

To listen to or request a copy of this leaflet in Braille, large print or audio please call, free of charge:

0800 198 5000 (UK Only) Please be ready to give the following information: Product name Imigran 50 mg tablet

Imigran 100 mg tablet Reference number 10949/0222 This is a service provided by the Royal National Institute of Blind People. Leaflet date: March 2016

United Kingdom-GBR Imigran N/A

Imigran and the Imigran logo are registered trade marks of the GSK group of companies © 2016 GSK group of companies. All rights reserved

• The other ingredients in the tablets are lactose, microcrystalline cellulose, croscarmellose sodium, magnesium stearate, methylhydroxypropylcellulose (E464) and titanium dioxide (E171). The 50 mg tablet also contains triacetin and iron oxide (E172).

What Imigran looks like and contents of the pack

Imigran 50 mg tablets are pink and capsule-shaped. They are available in a blister pack containing 6 tablets. Imigran 100 mg tablets are white and capsule-shaped. They are available in a blister pack containing 6 tablets.

Poznan – Additional Artwork Information Panel Leaflet / dimensions after folding

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Colistin (Colistimethate Sodium) Injection Uses, Side Effects, Interactions, Pictures, Warnings - Do

colistin (colistimethate sodium) injection

GENERIC NAME(S): COLISTIN (AS COLISTIMETHATE SODIUM)

Uses

Colistimethate is an antibiotic used to treat certain bacterial infections. It works by stopping the growth of bacteria.

OTHER USES: This section contains uses of this drug that are not listed in the approved US professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.

In patients with cystic fibrosis. inhaled colistimethate may be used to treat serious bacterial lung infections (Pseudomonas aeruginosa ). See also the Storage section for information about important safety concerns when this medication is inhaled.

How to use colistin (colistimethate sodium) injection

Colistimethate for injection is usually given into a vein or a muscle as directed by your doctor. The dosage is based on your medical condition and response to treatment.

If you are giving this medication to yourself at home, learn all preparation and usage instructions from your health care professional. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard medical supplies safely.

If you are inhaling this medication, learn how to prepare the solution and use the nebulizer machine properly. See also the Storage section. If you have any questions, ask your health care professional.

Antibiotics work best when the amount of medicine in your body is kept at a constant level. Therefore, use this drug at evenly spaced intervals.

Continue to use this medication until the full prescribed amount is finished, even if symptoms disappear after a few days. Stopping the medication too early may result in a return of the infection.

Tell your doctor if your condition does not improve or if it worsens.

Side Effects

Stomach upset and itching may occur. If either of these effects persists or worsens, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: numbness/tingling (especially of the arms/legs, around the mouth /tongue ), strange feeling on the skin of the arms/legs, mental/mood changes (such as confusion, psychosis. seizures ), difficulty walking, unsteadiness, slow/shallow/troubled breathing, dizziness /feeling of spinning, unexplained fever. slurred speech, muscle weakness. signs of kidney problems (such as change in the amount of urine), red/pink urine.

This medication may rarely cause a severe intestinal condition (Clostridium difficile - associated diarrhea ) due to a type of resistant bacteria. This condition may occur during treatment or weeks to months after treatment has stopped. Do not use anti-diarrhea products or narcotic pain medications if you have any of the following symptoms because these products may make them worse. Tell your doctor right away if you develop: persistent diarrhea, abdominal or stomach pain /cramping, blood /mucus in your stool.

Use of this medication for prolonged or repeated periods may result in a new infection. Tell your doctor if you notice any symptoms of a new infection (such as white patches in your mouth. a change in vaginal discharge ).

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction. including: rash. itching /swelling (especially of the face/tongue /throat), severe dizziness, trouble breathing .

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before using colistimethate, tell your doctor or pharmacist if you are allergic to it; or to polymyxin B or colistin; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: diseases of the nerves/muscles (such as myasthenia gravis ), kidney disease .

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

Before having surgery or any procedure requiring anesthesia or medications that block nerve or muscle activity, tell your doctor or dentist that you are using this medication.

This medication may cause live bacterial vaccines (such as typhoid vaccine) not to work as well. Therefore, do not have any immunizations /vaccinations while using this medication without the consent of your doctor.

Older adults may be more sensitive to the side effects of this drug, especially kidney problems.

During pregnancy. this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this drug passes into breast milk. Consult your doctor before breast - feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: cephalothin.

Although most antibiotics are unlikely to affect hormonal birth control such as pills, patch, or ring, a few antibiotics (such as rifampin, rifabutin) can decrease their effectiveness. This could result in pregnancy. If you use hormonal birth control. ask your doctor or pharmacist for more details.

Overdose

If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: extreme drowsiness, slow/shallow breathing, muscle weakness, inability to move.

Notes

Do not share this medication with others.

Laboratory and/or medical tests (such as kidney tests) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

Missed Dose

For the best possible benefit, it is important to receive each scheduled dose of this medication as directed. If you miss an injection, contact your doctor or pharmacist right away to establish a new dosing schedule. Do not double the dose to catch up.

If you miss an inhaled dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

For colistimethate injection, consult the product instructions and your pharmacist for storage details.

If you are using colistimethate as an inhalation, store the unmixed vials at room temperature. Do not use premixed solution or prepare the solution ahead of time because this increases the risk of very serious breathing problems. Prepare the inhalation solution right before use. Discard any unused solution after 24 hours. Do not store for longer periods. Ask your health care professional for details.

Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Information last revised May 2016. Copyright(c) 2016 First Databank, Inc.

Images

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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Relied - Definition Of Relied By The Free Dictionary, Relide

2. To place or have faith or confidence: relied on them to tell him the truth.

Synonyms: rely , depend , trust These verbs share the meaning to place or have faith or confidence in someone or something: He relies on his parents for support. Our theater group depends on volunteers to act as ushers. I trust my sister's advice.

rely

1. to be dependent (on): he relies on his charm.

2. to have trust or confidence (in): you can rely on us.

[C14: from Old French relier to fasten together, repair, from Latin religare to tie back, from re - + ligare to tie]

re•ly

to depend confidently; put trust in (usu. fol. by on or upon ): Can I rely on your support?

[1300–50; Middle English < Middle French relier < Latin religāre to bind fast, hold firmly. See re -, ligament ]

rely

Past participle: relied Gerund: relying

(= be dependent ) to rely on sth → dependre de qch We're relying on good weather → Nous dependons du temps.

rely

vi to rely (up)on somebody/something → sich auf jdn /etw verlassen ; (= be dependent on) → auf jdn /etw angewiesen sein ; she relied on the trains being on time → sie verlie? sich darauf, dass die Zuge punktlich waren ; I rely on him for my income → ich bin finanziell auf ihn angewiesen ; you can rely (up)on my help or on me to help you → du kannst dich darauf verlassen. dass ich dir helfe ; she is not to be relied upon → man kann sich nicht auf sie verlassen

rely

[rɪˈlaɪ] vi to rely on sb/sth ( count on ) → contare su qn/qc ; ( be dependent on ) → dipendere da qn/qc you can rely on my discretion → puoi fidarti della mia discrezione you can't rely on the trains → non si puo fare affidamento sui treni she relies on him for financial support → dipende da lui finanziariamente

rely

1. to depend on or need. The people on the island relied on the supplies that were brought from the mainland; I am relying on you to help me. maak staat ????????? ??? разчитам contar com spolehat na sich verlassen auf v?re afh?ngig af ?????????, ????????? contar con toetuma ??? ????? ?????? ???? riippua compter sur ??????? ??????? ??????? ???? uzdati se u, osloniti se na szamit vkire, vmire tergantung rei?a sig a contare su* ?? ???? priklausyti but atkarigam; palauties bergantung vertrouwen op. zich verlaten op stole pa. v?re avhengig av zdac sie na ??? ???. ???? ?????????? ??????????? contar com a conta pe зависеть spoliehat sa na zanasati se osloniti se vara beroende av ????? guvenmek. itimat etmek ??,?? покладатися ?????? ???? ph? thu?c ??

2. to trust (someone) to do something; to be certain that (something will happen). Can he rely on him to keep a secret?; He can be relied on; That is what will probably happen, but we can't rely on it. vertrou ?????? ????????? разчитам confiar pocitat (s) vertrauen auf stole pa ????????????. ????????? ?? ??. confiar en. contar con lootma ?????? ???? luottaa compter sur ??????? ??? - ?????? ???? pouzdati se (meg)bizik vkiben, vmiben mempercayai treysta contare su* ????? ?? pasitiketi palauties; ticet mempercayai vertrouwen op. rekenen op stole pa polegac ?????? ??? confiar a conta pe; a se baza pe полагаться ; доверять pocitat (s) zanesti se pouzdati se lita pa ??????? guvenmek. itimat etmek ??, ?? довіряти ?????? ???? tin tu?ng ??. ??

re?liable ( - ?lai - ) adjective

( negative unreliable ) able to be trusted. Is he reliable?; Is this information reliable? betroubaar ??????? ???? ????????? ???????? надежден de confianca spolehlivy zuverlassig palidelig ?????????? fiable. de confianza usaldatav ???? ??????? luotettava fiable ???? ??????? ????? pouzdan, pouzdana osoba megbizhato bisa dipercaya arei?anlegur affidabile ????? ?? ? ?? patikimas uzticams; dross boleh dipercayai betrouwbaar palitelig. til a stole pa godny zaufania. rzetelny ???????? ????????? ??????? ???????? ????? de confianca de incredere; sigur надёжный; достоверный spolahlivy zanesljiv pouzdan palitlig ??????????? guvenilir ???? надійний; достовірний ???? ?????? co th? tin tu?ng ????

betroubaarheid ?????????????? ?????????? надеждност confianca spolehlivost die Zuverlassigkeit palidelighed ?????????? fiabilidad usaldatavus ??????? ?????? ??????? luotettavuus serieux ?????? ??????????? pouzdanost megbizhatosag sifat bisa dipercaya arei?anleiki affidabilita ??? ??? patikimumas uzticamiba; palaviba kebenaran betrouwbaarheid palitelighet niezawodnosc, rzetelnosc ???? ???? ????? ??? confianca trainicie; siguranta надежность; достоверность spolahlivost zanesljivost pouzdanost palitlighet ???????????? guvenilirlik ??? надійність; достовірність ?????? s? dang tin tu?ng ???

re?liably ( - ?lai - ) adverb

from a reliable source; by a reliable person. I am reliably informed that the Prime Minister is going to resign. betroubaar ?????? ??????? надеждно confiantemente spolehlive zuverlassig palideligt; fra en palidelig kilde ??? ????????? ???? por una fuente fiable, por medios fiables usaldusvaarselt ?? ??? ???? ?????? luotettavasti de source sure ??????? ???????? ?????????????, ???????? ???? ?? pouzdano megbizhato forrasbol dari sumber yang dipercaya eftir arei?anlegum heimildum (da fonte sicura) ??? ??? ? ?? patikimai ticami; drosi dari sumber yang boleh dipercayai betrouwbaar fra palitelig hold wiarogodnie ?? ??????? ?? ???? ??? seguramente din sursa sigura достоверно spolahlivy zanesljivo pouzdano tillforlitligt, vederhaftigt ?????????????????????? emin olarak ??? надійно ???? ?????? ????? ?? dang tin c?y ???

re?liance ( - ?lai - ) noun

a country's reliance on aid from other countries; a child's reliance on its mother. afhanklikheid ????????? ????? упование dependencia spolehani das Vertrauen afh?ngighed ???????? dependencia soltuvus ??????? ?????? riippuvaisuus dependance ???? ??? ?? ??????? ???? ???, ?????? ???? ???, ???????? pouzdanje, oslonac bizalom ketergantungan ?a? a? vera ha?ur/rei?a sig a dipendenza. affidamento ??? ?? priklausomybe palausanas (uz kaut ko) kebergantungan afhankelijkheid avhengighet poleganie, zaufanie ????? ??????? ????? ????? ??? dependencia sprijin доверие spoliehanie sa (na) odvisnost oslanjanje tillit, fortrostan ?????????? bag?ml?l?k ??,?? довіра, впевненість ????? s? nh? c?y ??

afhanklik ?????? ????????? ??? доверчив dependente odkazany, spolehajici se vertrauensvoll afh?ngig ??????????? dependiente soltuv ????? ?????? ????? riippuvainen dependant. confiant ???? ????? ???? ???? koji se uzda (oslanja) bizalommal levo tergantung ha?ur, sem rei?ir sig a e-?/e-n dipendente. fiducioso ?????? ???? ?? priklausomas palavigs bergantung afhankelijk avhengig ufny ???? dependente bazat pe уверенный; зависимый odkazany, spoliehajuci sa odvisen zavisan tillits-, fortrostansfull ??????????? bag?ml?. muhtac ??? упевнений ??? ?????? dang tin c?y ???

rely

v. depender, contar con, confiar en.

References in classic literature ?

Hawkeye, at the same time that he had presumed so far on the nature of the Indian superstitions, was not ignorant that they were rather tolerated than relied on by the wisest of the chiefs.

His gestures, his gait, his grizzled beard, his slightest and most indifferent acts, the very fashion of his garments, were odious in the clergyman's sight; a token implicitly to be relied on of a deeper antipathy in the breast of the latter than he was willing to acknowledge to himself.

I had not a little relied on Queequeg's sagacity to point out the whaler best fitted to carry us and our fortunes securely.

As a result of her desertion, two infants who relied upon her to prompt them (she knew the verses of all the children better than they did themselves) broke down ignominiously.

His attentive behaviour to herself and his sisters convinced her that their welfare was dear to him, and, for a long time, she firmly relied on the liberality of his intentions.

Lecount's statement is to be relied on, Magdalen has carried her mad resolution of recovering her father's fortune to the last and most desperate extremity -- she has married Michael Vanstone's son under a false name.

Moreover, it was the spot to which such French intelligence as was most to be relied upon, came quickest.

If I rang the bell impatiently, after half-a-dozen unavailing modest pulls, and she appeared at last - which was not by any means to be relied upon - she would appear with a reproachful aspect, sink breathless on a chair near the door, lay her hand upon her nankeen bosom, and become so ill, that I was glad, at any sacrifice of brandy or anything else, to get rid of her.

Therefore, when Herbert and I sat down with him by his fire, I asked him first of all whether he relied on Wemmick's judgment and sources of information?

Scottish manners, Scottish dialect, and Scottish characters of note, being those with which the author was most intimately, and familiarly acquainted, were the groundwork upon which he had hitherto relied for giving effect to his narrative.

I relied on the fellow being a gentleman," said Sir Charles warmly.

She relied upon them to hold themselves prepared for any eventuality and to silence the adversaries, if, as she feared, they created a disturbance.

Flagyl Er, Strazyl

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What should my health care professional know before I take this medicine?

They need to know if you have any of these conditions: anemia or other blood disorders disease of the nervous system fungal or yeast infection if you drink alcohol containing drinks liver disease seizures an unusual or allergic reaction to metronidazole, or other medicines, foods, dyes, or preservatives pregnant or trying to get pregnant breast-feeding

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Take this medicine by mouth with a full glass of water. Take your medicine at regular intervals. Do not take your medicine more often than directed. Take all of your medicine as directed even if you think you are better. Do not skip doses or stop your medicine early.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following: alcohol or any product that contains alcohol amprenavir oral solution disulfiram paclitaxel injection ritonavir oral solution sertraline oral solution sulfamethoxazole-trimethoprim injection

This medicine may also interact with the following: cimetidine lithium phenobarbital phenytoin warfarin

This list may not describe all possible interactions. Give your health care providers a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while taking this medicine?

Tell your doctor or health care professional if your symptoms do not improve or if they get worse.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells.

Avoid alcoholic drinks while you are taking this medicine and for three days afterward. Alcohol may make you feel dizzy, sick, or flushed.

If you are being treated for a sexually transmitted disease, avoid sexual contact until you have finished your treatment. Your sexual partner may also need treatment.

What side effects may I notice from this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible: allergic reactions like skin rash or hives, swelling of the face, lips, or tongue confusion, clumsiness dark or white patches in the mouth fever, infection numbness, tingling, pain or weakness in the hands or feet pain when passing urine seizures if you are unusually weak or tired vaginal irritation or discharge

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome): diarrhea headache metallic taste nausea stomach pain or cramps

This list may not describe all possible side effects.

Where can I keep my medicine?

Keep out of the reach of children.

Store at room temperature below 25 degrees C (77 degrees F). Protect from light. Keep the container tightly closed. Throw away any unused medicine after the expiration date.

Article Page, Sucralfatum

Sucralfate

Richard Jewell

University of Southampton School of Medicine, Southampton, UK

Available online 8 January 2008.

Sucralfate, a basic aluminum complex of sulfated sucrose, has been shown to be beneficial in the treatment of gastrointestinal irritations including reflux esophagitis …

Name of the Clinical Form

Related Names Source: EMTREE

Alsucral; Andapsin; Antepsin; Calfate; Carafate; Citogel; Crafilm; Cralsanic; EINECS 259-018-4; Gastral; Gastrogel; Hexagastron; HSDB 3926; Ipagastril; Keal; Novo-Sucralate; SCF; Sucari; Succosa; Sucrabest; Sucrager; Sucrafen; Sucral; Sucralan; Sulcralbene; Sucralfate; Sucralfato; Sucralfatum; Sucralfin; Sucralose; Sucralum; Sulcralstad; Sucramal; Sucramed; Sucraphil; Sucrate; Sucroral; Sucrosehydrogen sulphate basic aluminum salt; Sucrose octakis (hydrogen sulfate)aluminum complex; Sugar; Sugast; Sulcrate; Suril; Tiblex; Ulcar; Ulcerban; Ulcefate; Ulcerimin; Ulcerlmin; Ulcertec; Ulcetab; Ulcetic; Ulcogant; Ulcrast; Ulcufato; Ulcyte; Ulsanic; Urbal; Zenodian; Carafate (trade); aluminium sucrose sulfate; aluminum sucrose sulfate; antepsin; carafate; hexagastron; keal; sucralfin; sucramal; sucrose octasulfate aluminium; sucrose sulfate aluminum; sulcrate; ulcar; ulcar keal; ulcerimin; ulcerlmin; ulcogant; ulsanic; urbal; venter

Hexadeca-?-hydroxytetracosahydroxy-[? 8 -[1,3,4,6-tetra - O - sulfo-beta-D-fructofuranosyl-alpha-D-glucopyranosidetetrakis(hydrogen sulfato)(8-)]]hexadeca-aluminum; beta-D-fructofuranosyl-alpha-D-glucopyranoside octakis-(hydrogen sulfate)aluminum complex O'Neil et al (2001)

Fusid Indication, Action Of Fusid, Interactions, Fusid

Fusid [in more detail]

Fusid Indication:

For the treatment of edema associated with congestive heart failure, cirrhosis of the liver, and renal disease, including the nephrotic syndrome. Also for the treatment of hypertension alone or in combination with other antihypertensive agents.

Fusid Mechanism Of Action:

Fusid, by inhibiting the reabsorption of sodium and chloride in the ascending limb of the loop of Henle, increases the urinary excretion of sodium, chloride, and water. Fusid also increases the excretion of potassium, hydrogen, calcium, magnesium, ammonium, and phosphate and, as it inhibits carbonic anhydrase, bicarbonate.

Fusid Drug Interactions:

Amikacin Increased ototoxicity Cisplatin Increased ototoxicity Gentamicin Increased ototoxicity Kanamycin Increased ototoxicity Tobramycin Increased ototoxicity Streptomycin Increased ototoxicity Netilmicin Increased ototoxicity Deslanoside Possible electrolyte variations and arrhythmias Digoxin Possible electrolyte variations and arrhythmias Digitoxin Possible electrolyte variations and arrhythmias Ethotoin The hydantoin decreases the effect of furosemide Fosphenytoin The hydantoin decreases the effect of furosemide Phenytoin The hydantoin decreases the effect of furosemide Mephenytoin The hydantoin decreases the effect of furosemide Ginseng Ginseng decreases the therapeutic effect Ibuprofen The NSAID decreases the diuretic and antihypertensive effects of the loop diuretic Indomethacin The NSAID decreases the diuretic and antihypertensive effects of the loop diuretic Sulindac The NSAID decreases the diuretic and antihypertensive effects of the loop diuretic

Food Interactions:

Avoid alcohol. Avoid excess salt/sodium unless otherwise instructed by your physician. Increase potassium intake; add a banana or orange juice; unless instructed otherwise. Take with food to reduce irritation.

Fusid Chemical Formula:

Dolmax - Manufacturer From Hosur, India, Dolmax

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Enalapril

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Acyclovir Tablets - Fda Prescribing Information, Side Effects And Uses, Vilerm

Acyclovir Tablets

Acyclovir Tablets Description

Acyclovir is a synthetic nucleoside analogue active against herpes viruses. Acyclovir Tablets are a formulation for oral administration. Each 800 mg tablet of acyclovir contains 800 mg of acyclovir and the inactive ingredients colloidal silicon dioxide, croscarmellose sodium, magnesium stearate and microcrystalline cellulose. Each 400 mg tablet of acyclovir contains 400 mg of acyclovir and the inactive ingredients colloidal silicon dioxide, croscarmellose sodium, magnesium stearate and microcrystalline cellulose.

Acyclovir is a white, crystalline powder with the molecular formula C 8 H 11 N 5 O 3 and a molecular weight of 225.2. The maximum solubility in water at 37°C is 2.5 mg/mL. The pKa’s of acyclovir are 2.27 and 9.25.

The chemical name of acyclovir is 2-amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6 H - purin-6-one; it has the following structural formula:

VIROLOGY

Mechanism of Antiviral Action

Acyclovir is a synthetic purine nucleoside analogue with in vitro and in vivo inhibitory activity against herpes simplex virus types 1 (HSV-1), 2 (HSV-2), and varicella-zoster virus (VZV).

The inhibitory activity of acyclovir is highly selective due to its affinity for the enzyme thymidine kinase (TK) encoded by HSV and VZV. This viral enzyme converts acyclovir into acyclovir monophosphate, a nucleotide analogue. The monophosphate is further converted into diphosphate by cellular guanylate kinase and into triphosphate by a number of cellular enzymes. I n vitro. acyclovir triphosphate stops replication of herpes viral DNA. This is accomplished in 3 ways: 1) competitive inhibition of viral DNA polymerase, 2) incorporation into and termination of the growing viral DNA chain, and 3) inactivation of the viral DNA polymerase. The greater antiviral activity of acyclovir against HSV compared to VZV is due to its more efficient phosphorylation by the viral TK.

Antiviral Activities

The quantitative relationship between the in vitro susceptibility of herpes viruses to antivirals and the clinical response to therapy has not been established in humans, and virus sensitivity testing has not been standardized. Sensitivity testing results, expressed as the concentration of drug required to inhibit by 50% the growth of virus in cell culture (IC 50 ), vary greatly depending upon a number of factors. Using plaque-reduction assays, the IC 50 against herpes simplex virus isolates ranges from 0.02 to 13.5 mcg/mL for HSV-1 and from 0.01 to 9.9 mcg/mL for HSV-2. The IC 50 for acyclovir against most laboratory strains and clinical isolates of VZV ranges from 0.12 to 10.8 mcg/mL. Acyclovir also demonstrates activity against the Oka vaccine strain of VZV with a mean IC 50 of 1.35 mcg/mL.

Drug Resistance

Resistance of HSV and VZV to acyclovir can result from qualitative and quantitative changes in the viral TK and/or DNA polymerase. Clinical isolates of HSV and VZV with reduced susceptibility to acyclovir have been recovered from immunocompromised patients, especially with advanced HIV infection. While most of the acyclovir-resistant mutants isolated thus far from immunocompromised patients have been found to be TK-deficient mutants, other mutants involving the viral TK gene (TK partial and TK altered) and DNA polymerase have been isolated. TK-negative mutants may cause severe disease in infants and immunocompromised adults. The possibility of viral resistance to acyclovir should be considered in patients who show poor clinical response during therapy.

Acyclovir Tablets - Clinical Pharmacology

Pharmacokinetics

The pharmacokinetics of acyclovir after oral administration have been evaluated in healthy volunteers and in immunocompromised patients with herpes simplex or varicella-zoster virus infection. Acyclovir pharmacokinetic parameters are summarized in Table 1.

Table 1: Acyclovir Pharmacokinetic Characteristics (Range)

* Bioavailability decreases with increasing dose.

There was no effect of food on the absorption of acyclovir (n = 6); therefore, Acyclovir Tablets may be administered with or without food. The only known urinary metabolite is 9-[(carboxymethoxy)methyl]guanine.

Special Populations

Adults with Impaired Renal Function

The half-life and total body clearance of acyclovir are dependent on renal function. A dosage adjustment is recommended for patients with reduced renal function (see DOSAGE AND ADMINISTRATION ).

Acyclovir plasma concentrations are higher in geriatric patients compared to younger adults, in part due to age-related changes in renal function. Dosage reduction may be required in geriatric patients with underlying renal impairment (see PRECAUTIONS: Geriatric Use ).

In general, the pharmacokinetics of acyclovir in pediatric patients is similar to that of adults. Mean half-life after oral doses of 300 mg/m 2 and 600 mg/m 2 in pediatric patients aged 7 months to 7 years was 2.6 hours (range 1.59 to 3.74 hours).

Drug Interactions

Coadministration of probenecid with intravenous acyclovir has been shown to increase the mean acyclovir half-life and the area under the concentration-time curve. Urinary excretion and renal clearance were correspondingly reduced.

Clinical Trials

Initial Genital Herpes

Double-blind, placebo-controlled studies have demonstrated that orally administered acyclovir significantly reduced the duration of acute infection and duration of lesion healing. The duration of pain and new lesion formation was decreased in some patient groups.

Recurrent Genital Herpes

Double-blind, placebo-controlled studies in patients with frequent recurrences (6 or more episodes per year) have shown that orally administered acyclovir given daily for 4 months to 10 years prevented or reduced the frequency and/or severity of recurrences in greater than 95% of patients.

In a study of patients who received acyclovir 400 mg twice daily for 3 years, 45%, 52%, and 63% of patients remained free of recurrences in the first, second, and third years, respectively. Serial analyses of the 3-month recurrence rates for the patients showed that 71% to 87% were recurrence free in each quarter.

Herpes Zoster Infections

In a double-blind, placebo-controlled study of immunocompetent patients with localized cutaneous zoster infection, acyclovir (800 mg 5 times daily for 10 days) shortened the times to lesion scabbing, healing, and complete cessation of pain, and reduced the duration of viral shedding and the duration of new lesion formation.

In a similar double-blind, placebo-controlled study, acyclovir (800 mg 5 times daily for 7 days) shortened the times to complete lesion scabbing, healing, and cessation of pain; reduced the duration of new lesion formation; and reduced the prevalence of localized zoster-associated neurologic symptoms (paresthesia, dysesthesia, or hyperesthesia).

Treatment was begun within 72 hours of rash onset and was most effective if started within the first 48 hours.

Adults greater than 50 years of age showed greater benefit.

Three randomized, double-blind, placebo-controlled trials were conducted in 993 pediatric patients aged 2 to 18 years with chickenpox. All patients were treated within 24 hours after the onset of rash. In 2 trials, acyclovir was administered at 20 mg/kg 4 times daily (up to 3,200 mg per day) for 5 days. In the third trial, doses of 10, 15, or 20 mg/kg were administered 4 times daily for 5 to 7 days. Treatment with acyclovir shortened the time to 50% healing; reduced the maximum number of lesions; reduced the median number of vesicles; decreased the median number of residual lesions on day 28; and decreased the proportion of patients with fever, anorexia, and lethargy by day 2. Treatment with acyclovir did not affect varicella-zoster virus-specific humoral or cellular immune responses at 1 month or 1 year following treatment.

Indications and Usage for Acyclovir Tablets

Herpes Zoster Infections

Acyclovir Tablets are indicated for the acute treatment of herpes zoster (shingles).

Genital Herpes

Acyclovir Tablets are indicated for the treatment of initial episodes and the management of recurrent episodes of genital herpes.

Chickenpox

Acyclovir Tablets are indicated for the treatment of chickenpox (varicella).

Contraindications

Acyclovir is contraindicated for patients who develop hypersensitivity to acyclovir or valacyclovir.

Warnings

Acyclovir Tablets are intended for oral ingestion only. Renal failure, in some cases resulting in death, has been observed with acyclovir therapy (see ADVERSE REACTIONS: Observed During Clinical Practice and OVERDOSAGE ). Thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS), which has resulted in death, has occurred in immunocompromised patients receiving acyclovir therapy.

Precautions

Dosage adjustment is recommended when administering acyclovir to patients with renal impairment (see DOSAGE AND ADMINISTRATION). Caution should also be exercised when administering acyclovir to patients receiving potentially nephrotoxic agents since this may increase the risk of renal dysfunction and/or the risk of reversible central nervous system symptoms such as those that have been reported in patients treated with intravenous acyclovir. Adequate hydration should be maintained.

Information for Patients

Patients are instructed to consult with their physician if they experience severe or troublesome adverse reactions, they become pregnant or intend to become pregnant, they intend to breastfeed while taking orally administered acyclovir, or they have any other questions.

Patients should be advised to maintain adequate hydration.

There are no data on treatment initiated more than 72 hours after onset of the zoster rash. Patients should be advised to initiate treatment as soon as possible after a diagnosis of herpes zoster.

Genital Herpes Infections

Patients should be informed that acyclovir is not a cure for genital herpes. There are no data evaluating whether acyclovir will prevent transmission of infection to others. Because genital herpes is a sexually transmitted disease, patients should avoid contact with lesions or intercourse when lesions and/or symptoms are present to avoid infecting partners. Genital herpes can also be transmitted in the absence of symptoms through asymptomatic viral shedding. If medical management of a genital herpes recurrence is indicated, patients should be advised to initiate therapy at the first sign or symptom of an episode.

Chickenpox in otherwise healthy children is usually a self-limited disease of mild to moderate severity. Adolescents and adults tend to have more severe disease. Treatment was initiated within 24 hours of the typical chickenpox rash in the controlled studies, and there is no information regarding the effects of treatment begun later in the disease course.

Drug Interactions

Carcinogenesis, Mutagenesis, Impairment of Fertility

The data presented below include references to peak steady-state plasma acyclovir concentrations observed in humans treated with 800 mg given orally 5 times a day (dosing appropriate for treatment of herpes zoster) or 200 mg given orally 5 times a day (dosing appropriate for treatment of genital herpes). Plasma drug concentrations in animal studies are expressed as multiples of human exposure to acyclovir at the higher and lower dosing schedules (see CLINICAL PHARMACOLOGY: Pharmacokinetics ).

Acyclovir was tested in lifetime bioassays in rats and mice at single daily doses of up to 450 mg/kg administered by gavage. There was no statistically significant difference in the incidence of tumors between treated and control animals, nor did acyclovir shorten the latency of tumors. Maximum plasma concentrations were 3 to 6 times human levels in the mouse bioassay and 1 to 2 times human levels in the rat bioassay.

Acyclovir was tested in 16 in vitro and in vivo genetic toxicity assays. Acyclovir was positive in 5 of the assays.

Acyclovir did not impair fertility or reproduction in mice (450 mg/kg/day, p. o.) or in rats (25 mg/kg/day, s. c.). In the mouse study, plasma levels were 9 to 18 times human levels, while in the rat study, they were 8 to 15 times human levels. At higher doses (50 mg/kg/day, s. c.) in rats and rabbits (11 to 22 and 16 to 31 times human levels, respectively) implantation efficacy, but not litter size, was decreased. In a rat peri - and post-natal study at 50 mg/kg/day, s. c. there was a statistically significant decrease in group mean numbers of corpora lutea, total implantation sites, and live fetuses.

No testicular abnormalities were seen in dogs given 50 mg/kg/day, IV for 1 month (21 to 41 times human levels) or in dogs given 60 mg/kg/day orally for 1 year (6 to 12 times human levels). Testicular atrophy and aspermatogenesis were observed in rats and dogs at higher dose levels.

Pregnancy

Pregnancy Category B. Acyclovir administered during organogenesis was not teratogenic in the mouse (450 mg/kg/day, p. o.), rabbit (50 mg/kg/day, s. c. and IV), or rat (50 mg/kg/day, s. c.). These exposures resulted in plasma levels 9 and 18, 16 and 106, and 11 and 22 times, respectively, human levels.

There are no adequate and well-controlled studies in pregnant women. A prospective epidemiologic registry of acyclovir use during pregnancy was established in 1984 and completed in April 1999. There were 749 pregnancies followed in women exposed to systemic acyclovir during the first trimester of pregnancy resulting in 756 outcomes. The occurrence rate of birth defects approximates that found in the general population. However, the small size of the registry is insufficient to evaluate the risk for less common defects or to permit reliable or definitive conclusions regarding the safety of acyclovir in pregnant women and their developing fetuses. Acyclovir should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Nursing Mothers

Acyclovir concentrations have been documented in breast milk in 2 women following oral administration of acyclovir and ranged from 0.6 to 4.1 times corresponding plasma levels. These concentrations would potentially expose the nursing infant to a dose of acyclovir up to 0.3 mg/kg/day. Acyclovir should be administered to a nursing mother with caution and only when indicated.

Pediatric Use

Safety and effectiveness of oral formulations of acyclovir in pediatric patients younger than 2 years of age have not been established.

Geriatric Use

Of 376 subjects who received acyclovir in a clinical study of herpes zoster treatment in immunocompetent subjects ≥50 years of age, 244 were 65 and over while 111 were 75 and over. No overall differences in effectiveness for time to cessation of new lesion formation or time to healing were reported between geriatric subjects and younger adult subjects. The duration of pain after healing was longer in patients 65 and over. Nausea, vomiting, and dizziness were reported more frequently in elderly subjects. Elderly patients are more likely to have reduced renal function and require dose reduction. Elderly patients are also more likely to have renal or CNS adverse events. With respect to CNS adverse events observed during clinical practice, somnolence, hallucinations, confusion, and coma were reported more frequently in elderly patients (see CLINICAL PHARMACOLOGY. ADVERSE REACTIONS: Observed During Clinical Practice. and DOSAGE AND ADMINISTRATION ).

Adverse Reactions

Herpes Simplex

The most frequent adverse events reported during clinical trials of treatment of genital herpes with acyclovir 200 mg administered orally 5 times daily every 4 hours for 10 days were nausea and/or vomiting in 8 of 298 patient treatments (2.7%). Nausea and/or vomiting occurred in 2 of 287 (0.7%) patients who received placebo.

The most frequent adverse events reported in a clinical trial for the prevention of recurrences with continuous administration of 400 mg (two 200-mg capsules) 2 times daily for 1 year in 586 patients treated with acyclovir were nausea (4.8%) and diarrhea (2.4%). The 589 control patients receiving intermittent treatment of recurrences with acyclovir for 1 year reported diarrhea (2.7%), nausea (2.4%), and headache (2.2%).

Herpes Zoster

The most frequent adverse event reported during 3 clinical trials of treatment of herpes zoster (shingles) with 800 mg of oral acyclovir 5 times daily for 7 to 10 days in 323 patients was malaise (11.5%). The 323 placebo recipients reported malaise (11.1%).

Chickenpox

The most frequent adverse event reported during 3 clinical trials of treatment of chickenpox with oral acyclovir at doses of 10 to 20 mg/kg 4 times daily for 5 to 7 days or 800 mg 4 times daily for 5 days in 495 patients was diarrhea (3.2%). The 498 patients receiving placebo reported diarrhea (2.2%).

Observed During Clinical Practice

In addition to adverse events reported from clinical trials, the following events have been identified during post-approval use of acyclovir. Because they are reported voluntarily from a population of unknown size, estimates of frequency cannot be made. These events have been chosen for inclusion due to either their seriousness, frequency of reporting, potential causal connection to acyclovir, or a combination of these factors.

General: Anaphylaxis, angioedema, fever, headache, pain, peripheral edema.

Nervous: Aggressive behavior, agitation, ataxia, coma, confusion, decreased consciousness, delirium, dizziness, dysarthria, encephalopathy, hallucinations, paresthesia, psychosis, seizure, somnolence, tremors. These symptoms may be marked, particularly in older adults or in patients with renal impairment (see PRECAUTIONS ).

Digestive: Diarrhea, gastrointestinal distress, nausea.

Hematologic and Lymphatic: Anemia, leukocytoclastic vasculitis, leukopenia, lymphadenopathy, thrombocytopenia.

Hepatobiliary Tract and Pancreas: Elevated liver function tests, hepatitis, hyperbilirubinemia, jaundice.

Skin: Alopecia, erythema multiforme, photosensitive rash, pruritus, rash, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria.

Special Senses: Visual abnormalities.

Urogenital: Renal failure, elevated blood urea nitrogen, elevated creatinine, hematuria (see WARNINGS).

Overdosage

Overdoses involving ingestion of up to 100 capsules (20 g) have been reported. Adverse events that have been reported in association with overdosage include agitation, coma, seizures, and lethargy. Precipitation of acyclovir in renal tubules may occur when the solubility (2.5 mg/mL) is exceeded in the intratubular fluid. Overdosage has been reported following bolus injections or inappropriately high doses and in patients whose fluid and electrolyte balance were not properly monitored. This has resulted in elevated BUN and serum creatinine and subsequent renal failure. In the event of acute renal failure and anuria, the patient may benefit from hemodialysis until renal function is restored (see DOSAGE AND ADMINISTRATION ).

Acyclovir Tablets Dosage and Administration

Acute Treatment of Herpes Zoster

800 mg every 4 hours orally, 5 times daily for 7 to 10 days.

Genital Herpes

Treatment of Initial Genital Herpes

200 mg every 4 hours, 5 times daily for 10 days.

Chronic Suppressive Therapy for Recurrent Disease

400 mg 2 times daily for up to 12 months, followed by re-evaluation. Alternative regimens have included doses ranging from 200 mg 3 times daily to 200 mg 5 times daily.

The frequency and severity of episodes of untreated genital herpes may change over time. After 1 year of therapy, the frequency and severity of the patient’s genital herpes infection should be re-evaluated to assess the need for continuation of therapy with acyclovir.

200 mg every 4 hours, 5 times daily for 5 days. Therapy should be initiated at the earliest sign or symptom (prodrome) of recurrence.

Treatment of Chickenpox

Children (2 years of age and older)

20 mg/kg per dose orally 4 times daily (80 mg/kg/day) for 5 days. Children over 40 kg should receive the adult dose for chickenpox.

Adults and Children over 40 kg

800 mg 4 times daily for 5 days.

Intravenous acyclovir is indicated for the treatment of varicella-zoster infections in immunocompromised patients.

When therapy is indicated, it should be initiated at the earliest sign or symptom of chickenpox. There is no information about the efficacy of therapy initiated more than 24 hours after onset of signs and symptoms.

Patients With Acute or Chronic Renal Impairment

In patients with renal impairment, the dose of acyclovir should be modified as shown in Table 3:

Table 3. Dosage Modification for Renal Impairment

Hemodialysis

For patients who require hemodialysis, the mean plasma half-life of acyclovir during hemodialysis is approximately 5 hours. This results in a 60% decrease in plasma concentrations following a 6-hour dialysis period. Therefore, the patient’s dosing schedule should be adjusted so that an additional dose is administered after each dialysis.

Peritoneal Dialysis

No supplemental dose appears to be necessary after adjustment of the dosing interval.

How is Acyclovir Tablets Supplied

Acyclovir Tablets, USP 800 mg are available for oral administration as white to off-white, oval, unscored tablets imprinted "Apotex Logo 5307" on one side and plain on the other side. They are supplied as follows:

300 TABLET in a BOTTLE (0440-7033-81)

Store at 20° to 25°C (68° to 77°F); excursions permitted from 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature] and protect from moisture.

Acyclovir Tablets, USP

400 MG & 800 MG

Viartril-S And The Healing Of Knee Joints In Asia, Viartril

FROM A 58 YEAR OLD JANUARY 2009:

ARTHRITIS & MINISCUS KNEE PROBLEMS

I have a bad left knee after a ski injury when I was young and playing Rugby. I had torn minisus in my knee so was rubbing bone to bone. The pain was unreal and I used Voltarens over the space of time on and off for 4 years but tried to keep away from pills till eventually it seemed to mend itself apart from the actual pain area when it jumped out. Fom time toi time the knee would jump out when I walked on uneven surfaces and I would hear a crack then sharp pain which wasn't pleasant. However I was determined to get better and I laid off the pills: tried to eat good foods and exercise more. It seemed to work. I could no go to the gym and work out even on the treadmill and walked a lot. However some 10 years later I walked on my farm and tripped and this must have dislodged the flap once again in 2008 and I was in agony again. Nothing seemed to help. I went to the Bangkok Hospital and ended up strapping my leg in a brace. I was also prescribed Viartril-S to take one packet every day for 3 months which I did. It seemed to work as well but then no exercise on top.

The research shows that 1500mg per day of Glucosamine Sulphate is the most effective way to rebuild cartilage in the knee. But you have to take 1500mg (usually 500mg with breakfast, lunch, and dinner), otherwise the effects will be negligable. Viartril-S (powder for oral solution, 1500mg glucosamine sulphate) daily. The recommended duration of the therapy is 3 months and the treatment course may be repeated at intervals of 2 months.

VIARTRIL-S is OK. Take one packet per day well brfore a meal for approx 2-3 months and watch how the compound feeds on your cartilage. It has worked for me and I took it daily before meals in a glass of water. Theres not much taste but its pleasant enough. Cost in Thailand at a pharmacy is 1200-1500baht per 1 month supply. The hospitals charge you 2500baht. VIARTRIL-S is a shelldish derivative from the shell & supposedly helps to rejuvenate the tissues in your knee. I had a scan and was going to have an operation but after 1month with a brace on my leg I started to feel better. Within 4 months my knee is back to walking Ok again but the odd times if I accidentally clip my leg on something that knee gets distorted and I get a sharp pain once again. VIARTRIL-S is is good for all forms of degenerative osteoarticular disease eg gonarthrosis, spondyloarthrosis, coxarthrosis, lumbosacral arthrosis

My ankles & knees get better when avoid foods with a lot of salt, especially Chinese food and stay away from MSG.

.

You also buy in tablet form 80 tablets. Internet sells for

PLEASE NOTE THE ABOVE INFORMATION IS FOR SUFFERERS ONLY. WE ARE NOT A LICENSED SUPPLIER OF THESE PRODUCTS as we do not hold a Pharmaceutical License.

Check out Pattaya/Bangkok Shipping & Transport services

DO YOURSELF AND BODY A FAVOUR:

HERE HOW TO AVOID HEART ATACKS:

To prevent heart attack it is important to eat the foods and have the drinks according to your Blood group. Eating the wrobng foods just increases heart attacks so check below on your blood groups and stick to this diet of foods. I found that whenever I ate roast meals with gravies or steaks with gravies I had to go to the toilet. I blamed the restaurant for the food but all along it was my body so once I changed my eating habits and I love vegetables (with small amounts of meats) I never had this problem. It works!

Read about Serious potential Yasmin side effects

deep vein thrombosis; gallbladder disease; hepatic neoplasia (liver cancer); hypertension (high blood pressure)

myocardial infarction ( heart attack) and other heart-related problems; stroke

thromboembolism [when a blood clot that formed in a blood vessel travels through the blood stream and plugs up another blood vessel in, for example, the lungs (a pulmonary embolism), the brain (a stroke), a leg or elsewhere

Alerte Spiramycine - Elevage Melhankozia, Buccoval

MDR1. Alerte Spiramycine (source CFBA)

La spiramycine, molécule active du Spiraphar, est un substrat de la P-Gp. La prise simultanée de spiramycine avec un inhibiteur de la P-Gp peut provoquer de graves effets secondaires chez l'être humain. Le même risque existe chez les chiens concernés par la mutation MDR1 et ce, de manière permanente s'ils sont homozygotes pour la mutation. La prudence voudrait qu'il ne soit pas donné à des chiens homozygotes (-/-) pour la mutation MDR1 et que toutes les précautions soient prises quant à son utilisation chez des chiens hétérozygotes (+/-) ou au profil MDR1 inconnu. Suite à suspicion de graves effets neurologiques causés par ce médicament chez une chienne Colley, nous le classons dans la catégorie "A éviter" compte-tenu du risque potentiel qu'il engendre en relation avec la mutation MDR1. Un avis qui pourra être modulé ultérieurement en fonction de nouvelles informations à ce sujet.

Médicaments à usage vétérinaire contenant de la spiramycine: BUCCOVAL CHIEN (Spiramycine + Métronidazole) HISTACETYL G. M. (Spiramycine + Dimétridazole) STOMORGYL (Spiramycine + Métronidazole) SPIRAPHAR CHIENS (Spiramycine + Dimétridazole)

Médicaments (médecine humaine), et génériques : RODOGYL (Métronidazole + Spiramycine) et MISSILOR Générique du Rodogyl) BIRODOGYL (Métronidazole + Spiramycine) et BI MISSILOR Générique du Birodogyl)

Synonymes : Rovamycine (Spiramycine) ou Rovamycin (Gb), Foromacidin, Leucomycin, Provamycin, Sequamycin, Selectomycin, Rovomycin.

1- Spiraphar. Un médicament à utiliser avec beaucoup de précautions chez les races concernées par la mutation MDR1 suite à suspicion de graves effets neurologiques causés par ce médicament. La prudence voudrait qu'il ne soit pas donné à des chiens homozygotes (-/-) pour la mutation MDR1 et que toutes les précautions soient prises quant à son utilisation chez des chiens hétérozygotes (+/-) ou au profil MDR1 inconnu. La spiramycine (antibiotique de la famille des macrolides), substrat de la P-Gp est probablement responsable des effets neurologiques, dont la violence ne peut trouver explication que par la conjonction d'effets aggravants: âge et chienne hétérozygote pour la mutation MDR1. Un avis qui pourra être modulé ultérieurement en fonction de nouvelles informations à ce sujet.

Autres médicaments (médecine humaine), génériques ou synonymes :

RODOGYL (Métronidazole + Spiramycine) et MISSILOR Générique du Rodogyl)

BIRODOGYL (Métronidazole + Spiramycine) et BI MISSILOR Générique du Birodogyl)

Synonymes. Rovamycine (Spiramycine) ou Rovamycin (Gb), Foromacidin, Leucomycin, Provamycin, Sequamycin, Selectomycin, Rovomycin.

2-Compte-tenu de l'augmentation importante des molécules identifiées comme étant un substrat de la P-Gp (154 molécules listées dans le dossier MDR1) : Nous ne pouvons que recommander aux propriétaires de chiens des races concernées par MDR1 de faire tester leurs chiens.

3- Nous recommandons dorénavant aux vétérinaires de demander aux propriétaires de chiens de ces races de connaitre le profil MDR1 de leur chien afin de minimiser, ou éviter, tout risque lié à la modification de la pharmacocinétique des médicaments pouvant être donnés à l'animal.

4- Enfin, l'âge de l'animal doit être pris en compte dans l'évaluation d'un risque médicamenteux lié à la mutation MDR1.

Prescolite Aktil Wh White Straight Mini-Joiner For Architrack Track Rail System, Aktil

Prescolite AKTIL WH

Prescolite AKTIL WH ArchiTrak Straight Mini-Joiner for ArchiTrack Track Rail System

Prescolite AKTIL WH Features:

Shown In Zet Metallic Silver Finish

Compatible With ArchiTrak One / Two Circuit Rails

Prescolite AKTIL WH Specifications:

Straight mini-joiner to mechanically and electrically couple any two trak lengths in a straight line. Add .078” (2mm) for the straight mini-joiner when calculating overall trak lengths.

Our SKU: AKTIL WH

This product is listed under the following manufacturer number(s):

Prescolite AKTIL WH White

*Denotes a finish or option that has been discontinued.

Inyeccion De Medroxiprogesterona Medlineplus Medicinas, Prodasone

Inyeccion de medroxiprogesterona

La inyeccion de medroxiprogesterona puede reducir la cantidad de calcio almacenado en sus huesos. El uso de este medicamento por largo tiempo, hara que sea mayor la reduccion de calcio en sus huesos. La cantidad de calcio en sus huesos podria no volver a normalizarse incluso despues de que usted deje de usar la inyeccion de medroxiprogesterona.

La perdida del calcio en sus huesos puede causar osteoporosis (una condicion en que los huesos se vuelven finos y debiles) y puede aumentar el riesgo de que usted tenga fracturas en algun momento de su vida, especialmente despues de la menopausia (cambio de vida).

La cantidad de calcio en los huesos generalmente aumenta durante la adolescencia. Una disminucion en el calcio de los huesos durante esta epoca importante del fortalecimiento oseo, puede ser especialmente grave. No se sabe si el riesgo de contraer osteoporosis en etapas posteriores de la vida aumentara si usted comienza a usar la inyeccion de medroxiprogesterona durante la adolescencia o a la edad de adulto joven. Digale a su doctor si usted o alguien en su familia tiene osteoporosis; si usted tiene o alguna vez ha tenido otra enfermedad osea o anorexia nerviosa (un trastorno de los habitos alimentarios); o si usted bebe mucho alcohol o fuma mucho. Digale a su doctor si usted toma cualquiera de los siguientes medicamentos: corticosteroides como dexametasona (Decadron, Dexone), metilprednisolona (Medrol) y prednisona (Deltasone), o medicamentos para las crisis convulsivas como carbamazepina (Tegretol), fenitoina (Dilantin) o fenobarbital (Luminal, Solfoton).

Usted no debe usar la inyeccion de medroxiprogesterona durante mucho tiempo (por ejemplo, por mas de 2 anos) a menos que ningun otro metodo de prevencion del embarazo sea adecuado para usted o que ningun otro medicamento funcione para tratar su condicion. Su doctor examinara sus huesos para estar seguro de que no se estan debilitando antes de que usted siga usando la inyeccion de medroxiprogesterona.

Cumpla con todas las citas con su doctor y el laboratorio. Su doctor vigilara su salud cuidadosamente para estar seguro de que usted no desarrolle osteoporosis.

Converse con su doctor acerca de los riesgos de usar la inyeccion de medroxiprogesterona.

?Para cuales condiciones o enfermedades se prescribe este medicamento?

La inyeccion intramuscular (en un musculo) o subcutanea (debajo de la piel) de medroxiprogesterona se usan para prevenir el embarazo. La inyeccion subcutanea de medroxiprogesterona es tambien usada para tratar la endometriosis [una condicion en la cual el tipo de tejido que reviste el utero (matriz), crece en otras areas del cuerpo y causa dolor, menstruacion (periodos) abundante o irregular, y otros sintomas]. La medroxiprogesterona pertenece a una clase de medicamentos llamados progestinas. Funciona para prevenir el embarazo al impedir la ovulacion (liberacion de huevos producidos por los ovarios). La medroxiprogesterona tambien hace mas delgado el recubrimiento del utero. Esto ayuda a prevenir el embarazo en las mujeres y enlentecer la difusion de tejido del utero a otras parte del cuerpo en mujeres que tienen endometriosis. La inyeccion de medroxiprogesterona es un metodo muy eficaz de prevencion del embarazo, pero no previenen la propagacion del virus de la inmunodeficiencia humana [VIH, el virus que causa el Sindrome de Inmunodeficiencia Adquirido (SIDA)], ni previene la transmision de otro tipo de enfermedades de transmision sexual.

?Como se debe usar este medicamento?

La inyeccion intramuscular de medroxiprogesterona viene como una suspension (liquido) para ser inyectada en las nalgas o en el brazo. Por lo general la inyeccion le sera administrada una vez cada 3 meses (13 semanas) por el personal medico en el consultorio o la clinica. La inyeccion subcutanea de medroxiprogesterona viene envasada en forma de una suspension para ser inyectada debajo de la piel. Por lo general es inyectada por el personal medico una vez cada 12 a 14 semanas en el consultoria o la clinica.

Usted debe recibir su primera inyeccion de medroxiprogesterona subcutanea o intramuscular solo en un momento en el que no haya ninguna posibilidad de que este embarazada. Por consiguiente, usted solo puede recibir su primera inyeccion durante los primeros 5 dias de una menstruacion normal, durante los primeros 5 dias despues de que usted ha dado a luz si no esta planificando amamantar a su bebe, o durante la sexta semana despues de dar a luz si usted esta planificando amamantar a su bebe. Si usted ha estado usando otro metodo de prevencion del embarazo y esta cambiando a la inyeccion de medroxiprogesterona, su doctor le dira cuando debera recibir la primera inyeccion.

?Que otro uso se le da a este medicamento?

Este medicamento tambien puede ser prescrito para otros usos; pidale mas informacion a su doctor o farmaceutico.

?Cuales son las precauciones especiales que debo seguir?

Antes de comenzar a usar la inyeccion de medroxiprogesterona:

digale a su doctor y a su farmaceutico si usted es alergico a la medroxiprogesterona (Depo-Provera, depo-subQ provera 104, Provera en Prempro, en Premphase) o a otros medicamentos.

digale a su doctor y a su farmaceutico que medicamentos con y sin prescripcion esta tomando o planea tomar, como por ejemplo vitaminas, suplementos nutricionales y productos fabricados a base de hierbas. Asegurese de mencionar los enumerados en la seccion de ADVERTENCIA y la aminoglutetimida (Cytadren). Su doctor podria necesitar cambiar la dosis de sus medicamentos o vigilarle cuidadosamente para evitar efectos secundarios.

digale a su doctor si usted o alguien en su familia tiene o alguna vez ha tenido cancer de seno o diabetes. Tambien digale a su doctor si tiene o alguna vez ha tenido problemas en sus senos como bultos, sangrando de sus pezones, un mamograma (radiografia de los senos) anormal, o enfermedades fibrocisticas en los senos (senos hinchados, sensibles y/o bultos en los senos que no son cancer); hemorragia vaginal sin causa aparente; menstruaciones irregulares o muy livianas; aumento de peso excesivo o retencion de liquido antes de su periodo; coagulacion de sangre en sus piernas, pulmones, cerebro u ojos; accidente cerebrovascular o miniaccidente cerebrovascular; migranas; crisis convulsivas; depresion; hipertension; ataques cardiacos; asma; o enfermedades al corazon, higado o rinon.

digale a su doctor si usted piensa que esta embarazada, si esta embarazada o si tiene planes de quedar embarazada. Si queda embarazada mientras usa este medicamento, llame a su doctor de inmediato. La medroxiprogesterona puede danar al feto.

digale a su doctor si usted esta amamantando. Usted podria usar la inyeccion de medroxiprogesterona mientras esta amamantando siempre que su bebe tenga 6 semanas cuando usted reciba su primera inyeccion. Cierta cantidad de medroxiprogesterona puede ser pasada a su bebe a traves de la leche materna, pero no se ha demostrado que esto pudiera ser perjudicial. Los estudios de los bebes que fueron amamantados mientras sus madres estaban usando la inyeccion de medroxiprogesterona revelaron que los bebes no sufrieron danos debido al medicamento.

si va a ser sometida a cualquier cirugia, incluida la dental, digale al doctor o dentista que esta tomando medroxiprogesterona.

usted debe saber que su ciclo menstrual probablemente cambiara mientras usa la inyeccion de medroxiprogesterona. Al principio, sus periodos probablemente seran irregulares, y puede experimentar manchado entre un periodo y otro. Si usted sigue usando este medicamento, sus periodos pueden detenerse completamente. Su ciclo menstrual probablemente se normalizara algun tiempo despues de que deje de usar este medicamento.

?Que dieta especial debo seguir mientras tomo este medicamento?

Usted debe comer alimentos ricos en calcio y vitamina D en abundancia mientras esta recibiendo la inyeccion de medroxiprogesterona, para ayudar a reducir la perdida de calcio de sus huesos. Su doctor le dira que alimentos son buenas fuentes de estos nutrientes y cuanto necesitara cada dia. Su doctor tambien podria prescribirle o recomendarle suplementos de calcio o de vitamina D.

?Que tengo que hacer si me olvido de tomar una dosis?

Si usted pierde una cita para recibir una inyeccion de medroxiprogesterona, llame a su doctor. Usted podria estar sin proteccion de prevencion del embarazo si no recibe sus inyecciones a tiempo. Si usted no recibe la inyeccion de acuerdo a lo programado, su doctor probablemente le dira que debe recibir la dosis perdida. Su doctor probablemente le realizara una prueba de embarazo para estar seguro de que usted no esta embarazada antes de administrarle la inyeccion que ha perdido. Usted deberia usar otro metodo de prevencion del embarazo, como condones, hasta que reciba la inyeccion que ha perdido.

?Cuales son los efectos secundarios que podria provocar este medicamento?

Aunque los efectos secundarios de este medicamento no son comunes, podrian llegar a presentarse. Digale a su doctor si cualquiera de estos sintomas se vuelve severo o si no desaparece:

cambios en el periodo menstrual (vea PRECAUCIONES ESPECIALES)

aumento de peso

debilidad

cansancio

nerviosismo

irritabilidad

depresion

dificultad para quedarse o permanecer dormida

sofocaciones

dolor, inflamacion o sensibilidad en los senos

retortijones o hinchazon abdominales

calambres en las piernas

dolor en la espalda o en las articulaciones

acne

perdida de cabello en el cuero cabelludo

hinchazon, enrojecimiento, irritacion, ardor, o prurito en la vagina

secresion vaginal blanca

cambios en el deseo sexual

sintomas de resfrio o gripe

dolor, irritacion, abultamientos, enrojecimiento o cicatrices en el lugar donde inyecto el medicamento

Algunos efectos secundarios pueden ser graves. Los siguientes sintomas son poco comunes, pero si usted experimenta cualquiera de ellos, llame a su doctor de inmediato:

respiracion entrecortada subita

dolor en el pecho subito, agudo o aplastante

tos con sangre

cefalea grave (dolor de cabeza grave)

malestar estomacal

vomitos

mareos o debilidad

cambio o perdida de la vision

vision doble

ojos protuberantes

dificultad para hablar

debilidad o adormecimiento en un brazo o pierna

crisis convulsivas

coloracion amarillenta de la piel o los ojos

cansancio extremo

dolor, hinchazon, calor, enrojecimiento o sensibilidad en una sola pierna

sangrado menstrual mas abundante o que dura mas tiempo que lo normal

dolor intenso o sensibilidad por debajo de la cintura

sarpullido (erupciones en la piel)

urticarias

prurito (picazon)

dificultad para respirar o tragar

hinchazon de las manos, pies, tobillos o piernas

coloracion amarillenta de la piel o los ojos

dificultad, dolor o aumento de la frecuencia para orinar

dolor constante, pus, calor, infamacion o sangrado en el lugar donde inyecto el medicamento

Si usted tiene menos de 35 anos de edad y empezo a recibir la inyeccion de medroxiprogesterona en los ultimos 4 o 5 anos, puede tener un riesgo algo mayor de desarrollar cancer de seno. La inyeccion de medroxiprogesterona tambien puede aumentar la oportunidad de que usted desarrolle coagulos sanguineos que pueden moverse hacia sus pulmones o cerebro. Converse con su doctor acerca de los riesgos de usar este medicamento.

La inyeccion de medroxiprogesterona es un metodo de prevencion del embarazo de accion prolongada. Usted podria no quedar embarazada por algun tiempo despues de recibir la ultima inyeccion. Converse con su doctor acerca de los efectos de usar esta medicamento si usted tiene planes de quedar embarazada en un futuro proximo.

La inyeccion de medroxiprogesterona puede provocar otros efectos secundarios. Llame a su doctor si tiene cualquier problema inusual mientras usa este medicamento.

?Como debo almacenar o desechar este medicamento?

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