Medofloxine Generic Name Ofloxacin Online, Medofloxine

Medofloxine General Information

Medofloxine acts on DNA gyrase, an enzyme which, like human topoisomerase, prevents the excessive supercoiling of DNA during replication or transcription.

Medofloxine for patients

PATIENT INFORMATION Patients should be advised:

- to drink fluids liberally;

- that mineral supplements, vitamins with iron or minerals, calcium-. aluminum-, or magnesium-based antacids, sucralfate or Videx, (Didanosine), chewable/buffered tablets or the pediatric powder for oral solution should not be taken within the two-hour period before or within the two-hour period after taking ofloxacin (See Drug Interactions);

- that ofloxacin can be taken without regard to meals;

- that ofloxacin may cause neurologic adverse effects (e. g. dizziness, lightheadedness) and that patients should know how they react to ofloxacin before they operate an automobile or machinery or engage in activities requiring mental alertness and coordination

- to discontinue treatment and inform their physician if they experience pain, inflammation, or rupture of a tendon, and to rest and refrain from exercise until the diagnosis of tendinitis or tendon rupture has been confidently excluded;

- that ofloxacin may be associated with hypersensitivity reactions, even following the first dose, to discontinue the drug at the first sign of a skin rash, hives or other skin reactions, a rapid heartbeat, difficulty in swallowing or breathing, any swelling suggesting angioedema (e. g. swelling of the lips, tongue, face; tightness of the throat, hoarseness), or any other symptom of an allergic reaction

- to avoid excessive sunlight or artificial ultraviolet light while receiving ofloxacin and to discontinue therapy if phototoxicity (e. g. skin eruption) occurs;

- that if they are diabetic and are being treated with insulin or an oral hypoglycemic drug, to discontinue ofloxacin immediately if a hypoglycemic reaction occurs and consult a physician

- that convulsions have been reported in patients taking quinolones, including ofloxacin, and to notify their physician before taking this drug if there is a history of this condition.

This description is suitable for active ingredient Ofloxacin

Medofloxine Interactions

Antacids, Sucralfate, Metal Cations, Multivitamins: Quinolones form chelates with alkaline earth and transition metal cations. Administration of quinolones with antacids containing calcium, magnesium, or aluminum, with sucralfate, with divalent or trivalent cations such as iron, or with multivitamins containing zinc or with Videx®, (Didanosine), chewable/buffered tablets or the pediatric powder for oral solution may substantially interfere with the absorption of quinolones resulting in systemic levels considerably lower than desired. These agents should not be taken within the two-hour period before or within the two-hour period after ofloxacin administration. Caffeine: Interactions between ofloxacin and caffeine have not been detected.

Cimetidine: Cimetidine has demonstrated interference with the elimination of some quinolones. This interference has resulted in significant increases in half-life and AUC of some quinolones. The potential for interaction between ofloxacin and cimetidine has not been studied.

Cyclosporine: Elevated serum levels of cyclosporine have been reported with concomitant use of cyclosporine with some other quinolones. The potential for interaction between ofloxacin and cyclosporine has not been studied.

Drugs metabolized by Cytochrome P450 enzymes: Most quinolone antimicrobial drugs inhibit cytochrome P450 enzyme activity. This may result in a prolonged half-life for some drugs that are also metabolized by this system (e. g. cyclosporine, theophylline/methylxanthines, warfarin) when co-administered with quinolones. The extent of this inhibition varies among different quinolones.

Non-steroidal anti-inflammatory drugs: The concomitant administration of a non-steroidal anti-inflammatory drug with a quinolone, including ofloxacin, may increase the risk of CNS stimulation and convulsive seizures.

Probenecid: The concomitant use of probenecid with certain other quinolones has been reported to affect renal tubular secretion. The effect of probenecid on the elimination of ofloxacin has not been studied.

Theophylline: Steady-state theophylline levels may increase when ofloxacin and theophylline are administered concurrently. As with other quinolones, concomitant administration of ofloxacin may prolong the half-life of theophylline, elevate serum theophylline levels, and increase the risk of theophylline-related adverse reactions. Theophylline levels should be closely monitored and theophylline dosage adjustments made, if appropriate, when ofloxacin is co-administered. Adverse reactions (including seizures) may occur with or without an elevation in the serum theophylline level.

Warfarin: Some quinolones have been reported to enhance the effects of the oral anticoagulant warfarin orits derivatives. Therefore, if a quinolone antimicrobial is administered concomitantly with warfarin or its derivatives, the prothrombin time or other suitable coagulation test should be closely monitored.

Antidiabetic agents (e. g. insulin, glyburide/glibenclamide): Since disturbances of blood glucose, including hyperglycemia and hypoglycemia, have been reported in patients treated concurrently with quinolones and an antidiabetic agent, careful monitoring of blood glucose is recommended when these agents are used concomitantly.

Medofloxine Contraindications

FLOXIN (ofloxacin) is contraindicated in persons with a history of hypersensitivity associated with the use of ofloxacin or any member of the quinolone group of antimicrobial agents.

This description is suitable for active ingredient Ofloxacin

Generic name, Overdose, Half Life Medofloxine, Food Interactions, Chemical, etc..

Medofloxine see also

Laevomycetin, Laevomycetin

Levomicetin

Roman name

Of drugs

Levomiietin antibiotic is a broad-spectrum; Effective for many grampolaugitionah and gramotricationah bacteria ricketsi, spirohet and some of the major viruses (disease trachoma / infectious eye disease that can lead to blindness / fever / acute infectious disease transmitted by humans from birds / chlamydia / IV venereal disease, a sexually transmitted disease; characterized by inflammation groin lymph nodes thereby festering sores / etc.); operates in strains of bacteria resistant to penitsillino, streptomitino, sulfanilamidam. In normal doses of bakteriostaticeski (prevents bacteria grow). Slaboakteven against acid bacteria, Escherichia Coli, claustridi and simple.

Indications

Typhoid fever, inc, dysentery, brucellosis, tularaemia, whooping cough, pneumonia, gonorrhoea, trachoma, psittakoz and other infectious diseases.

Contraindications

We can not allow uncontrolled levomicetina appointment and apply them in the light forms of the disease, especially in the child practice.

Side-Effects

When treating levomicetinom could experience despepsiceskie events (nausea, vomiting, liquid chair), irritation mucous membranes mouth, zev, skin rashes, dermatitis (skin inflammation), and skin irritation around the back passage and others.

Patient interaction

Incompatible with zitostatikami, sulfanilamidami, pirazolona derivatives.

Dosing and Administration

Inside for 20-30 minutes before meals-on 0,25-0,75 g 3-4 times a day, the highest daily intake - 3 and Non dose for children under 3 years 0,01-0,015 g / kg, 3-8 years ? grams over 8 years 0.2-0.3 g 3-4 times a day. The course of treatment is 10 days.

Storage conditions

caps. In the dark place at room temperature

Shelf life

The registration

Indications for use

Lswomiietin applied to bruchnom tife, paratifah, Generalized forms of salmonella, bruzelleze, tularemia and meningitis, riccetsnozah, hlamidiazah.

Form of

Answers to 0.25 and 0.5 g; Tablets, coated liner to 0.25 g; Levomicetina pill extended (long) acts, containing 0.65 grams of the drug (dwusloynye pills, the outer layer contains 0.25 g levomicetina internal 0.4 g), in a package of 10 pieces; Capsules containing 0.1; 0.25 and 0.5 g levomicetina, in a package of 10 or 16 capsules; 0.25% solution (eye drops) in the bottle for 10 ml. making exterior as antisepsis (decontamination) is used as a ready solution with levomicetina 2.5 g boric acid 1 g, ethyl alcohol 70% to 100 ml; levomicetina solution alcohol 0.25%; 1%; 3% and 5%.

All products of this group

Busta Brown, Bustab

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21 января в 2:42 · Доступно всем

GREENSBORO, N. C. – Greensboro police need your help in finding a missing teenager who could be in danger. Police are looking for Tyarra Cacique Williams, 19, who was last seen Thursday, January 7 with a group of friends in the area of Stoneybrook Apartments. A family member reported Williams missing the next day after being unable to get in contact with her. Family members told police this is out of character for the teenager. Williams was last seen wearing dark blue jeans, pink t-shirt, black…

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Two things you can't take back. A bullet and your words. Both has the ability to kill. The bullet. physic ally. The tongue. mental ly and spiritually. Anger will cause you to fire off both the tongue and the gun. So be slow to anger, because our lives matter. That's your Wonderful Wednesday Word for the day

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The Powerball jackpot continued to grow after no one was able to match the winning numbers Wednesday night. And Thursday the jackpot reached $700 million, the highest ever for Powerball. Players in North America have never had a chance to win a prize that size. At $675 million, it eclipses the previous record of $656 million set by a March 2012 Mega Millions jackpot. If claimed as a lump sum, the jackpot would be worth $413.1 million. The numbers, drawn late Wednesday night, were 2-11-47-62-63,…

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Polytrim - Fda Prescribing Information, Side Effects And Uses, Politrim

Polytrim

Polytrim Description

Polytrim ® (polymyxin B sulfate and trimethoprim ophthalmic solution, USP) is a sterile antimicrobial solution for topical ophthalmic use. It has pH of 4.0 to 6.2 and osmolality of 270 to 310 mOsm/kg.

Chemical Names:

Trimethoprim sulfate, 2,4-Diamino-5-(3,4,5-trimethoxybenzyl) pyrimidine sulfate, is a white, odorless, crystalline powder with a molecular weight of 678.72 and the following structural formula:

Polymyxin B sulfate is the sulfate salt of polymyxin B 1 and B 2 which are produced by the growth of Bacillus polymyxa (Prazmowski) Migula (Fam. Bacillaceae). It has a potency of not less than 6,000 polymyxin B units per mg, calculated on an anhydrous basis. The structural formulae are:

Contains: Actives: polymyxin B sulfate 10,000 units/mL; trimethoprim sulfate equivalent to 1 mg/mL. Preservative: benzalkonium chloride 0.04 mg/mL. Inactives: purified water; sodium chloride; and sulfuric acid. May also contain sodium hydroxide to adjust the pH.

Polytrim - Clinical Pharmacology

Trimethoprim is a synthetic antibacterial drug active against a wide variety of aerobic gram-positive and gram-negative ophthalmic pathogens. Trimethoprim blocks the production of tetrahydrofolic acid from dihydrofolic acid by binding to and reversibly inhibiting the enzyme dihydrofolate reductase. This binding is stronger for the bacterial enzyme than for the corresponding mammalian enzyme and therefore selectively interferes with bacterial biosynthesis of nucleic acids and proteins.

Polymyxin B, a cyclic lipopeptide antibiotic, is bactericidal for a variety of gram-negative organisms, especially Pseudomonas aeruginosa. It increases the permeability of the bacterial cell membrane by interacting with the phospholipid components of the membrane.

Blood samples were obtained from 11 human volunteers at 20 minutes, 1 hour and 3 hours following instillation in the eye of 2 drops of ophthalmic solution containing 1 mg trimethoprim and 10,000 units polymyxin B per mL. Peak serum concentrations were approximately 0.03μg/mL trimethoprim and 1 unit/mL polymyxin B.

Microbiology: In vitro studies have demonstrated that the anti-infective components of Polytrim ® are active against the following bacterial pathogens that are capable of causing external infections of the eye:

Trimethoprim: Staphylococcus aureus and Staphylococcus epidermidis, Streptococcus pyogenes, Streptococcus faecalis, Streptococcus pneumoniae, Haemophilus influenzae, Haemophilus aegyptius, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis (indole-negative). Proteus vulgaris (indole-positive). Enterobacter aerogenes and Serratia marcescens .

Polymyxin B: Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes and Haemophilus influenzae.

Indications and Usage for Polytrim

Polytrim ® Ophthalmic Solution is indicated in the treatment of surface ocular bacterial infections, including acute bacterial conjunctivitis, and blepharoconjunctivitis, caused by susceptible strains of the following microorganisms: Staphylococcus aureus. Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus viridans, Haemophilus influenzae and Pseudomonas aeruginosa. 1

1 Efficacy for this organism in this organ system was studied in fewer than 10 infections.

Contraindications

Polytrim ® Ophthalmic Solution is contraindicated in patients with known hypersensitivity to any of its components.

Warnings

NOT FOR INJECTION INTO THE EYE. If a sensitivity reaction to Polytrim ® occurs, discontinue use. Polytrim ® Ophthalmic Solution is not indicated for the prophylaxis or treatment of ophthalmia neonatorum.

Precautions

General:

As with other antimicrobial preparations, prolonged use may result in overgrowth of nonsusceptible organisms, including fungi. If superinfection occurs, appropriate therapy should be initiated.

Information for Patients:

Avoid contaminating the applicator tip with material from the eye, fingers, or other source. This precaution is necessary if the sterility of the drops is to be maintained.

If redness, irritation, swelling or pain persists or increases, discontinue use immediately and contact your physician. Patients should be advised not to wear contact lenses if they have signs and symptoms of ocular bacterial infections.

Carcinogenesis, Mutagenesis, Impairment of Fertility:

Carcinogenesis. Long-term studies in animals to evaluate carcinogenic potential have not been conducted with polymyxin B sulfate or trimethoprim.

Mutagenesis. Trimethoprim was demonstrated to be non-mutagenic in the Ames assay. In studies at two laboratories no chromosomal damage was detected in cultured Chinese hamster ovary cells at concentrations approximately 500 times human plasma levels after oral administration; at concentrations approximately 1,000 times human plasma levels after oral administration in these same cells, a low level of chromosomal damage was induced at one of the laboratories. Studies to evaluate mutagenic potential have not been conducted with polymyxin B sulfate.

Impairment of Fertility. Polymyxin B sulfate has been reported to impair the motility of equine sperm, but its effects on male or female fertility are unknown.

No adverse effects on fertility or general reproductive performance were observed in rats given trimethoprim in oral dosages as high as 70 mg/kg/day for males and 14 mg/kg/day for females.

Pregnancy:

Teratogenic Effects. Pregnancy Category C. Animal reproduction studies have not been conducted with polymyxin B sulfate. It is not known whether polymyxin B sulfate can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity.

Trimethoprim has been shown to be teratogenic in the rat when given in oral doses 40 times the human dose. In some rabbit studies, the overall increase in fetal loss (dead and resorbed and malformed conceptuses) was associated with oral doses 6 times the human therapeutic dose.

While there are no large well-controlled studies on the use of trimethoprim in pregnant women, Brumfitt and Pursell, in a retrospective study, reported the outcome of 186 pregnancies during which the mother received either placebo or oral trimethoprim in combination with sulfamethoxazole. The incidence of congenital abnormalities was 4.5% (3 of 66) in those who received placebo and 3.3% (4 of 120) in those receiving trimethoprim and sulfamethoxazole. There were no abnormalities in the 10 children whose mothers received the drug during the first trimester. In a separate survey, Brumfitt and Pursell also found no congenital abnormalities in 35 children whose mothers had received oral trimethoprim and sulfamethoxazole at the time of conception or shortly thereafter.

Because trimethoprim may interfere with folic acid metabolism, trimethoprim should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Nonteratogenic Effects. The oral administration of trimethoprim to rats at a dose of 70 mg/kg/day commencing with the last third of gestation and continuing through parturition and lactation caused no deleterious effects on gestation or pup growth and survival.

Nursing Mothers:

It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Polytrim ® Ophthalmic Solution is administered to a nursing woman.

Pediatric Use:

Safety and effectiveness in children below the age of 2 months have not been established (see WARNINGS ).

Geriatric Use:

No overall differences in safety or effectiveness have been observed between elderly and other adult patients.

Adverse Reactions

The most frequent adverse reaction to Polytrim ® Ophthalmic Solution is local irritation consisting of increased redness, burning, stinging, and/or itching. This may occur on instillation, within 48 hours, or at any time with extended use. There are also multiple reports of hypersensitivity reactions consisting of lid edema, itching, increased redness, tearing, and/or circumocular rash. Photosensitivity has been reported in patients taking oral trimethoprim.

Polytrim Dosage and Administration

In mild to moderate infections, instill one drop in the affected eye(s) every three hours (maximum of 6 doses per day) for a period of 7 to 10 days.

How is Polytrim Supplied

Polytrim ® (polymyxin B sulfate and trimethoprim ophthalmic solution, USP) is supplied sterile in opaque white low density polyethylene ophthalmic dispenser bottles and tips with white high impact polystyrene (HIPS) caps as follows:

10 mL in 10 mL bottle - NDC 0023-7824-10

Note. Store at 15˚ - 25˚ C (59˚ - 77˚ F) and protect from light.

Revised August 2004

© 2004 Allergan, Inc. Irvine, CA 92612, U. S.A. ® Marks owned by Allergan, Inc.

10 mL NDC 0023-7824-10 ALLERGAN Rx Only Polytrim® (POLYMYXIN B SULFATE AND TRIMETHOPRIM OPHTHALMIC SOULTION, USP) Sterile

NDC 0023-7824-10 Rx Only

Polytrim® (polymyxin B sulfate and trimethoprim ophthalmic solution, USP) sterile

Otolin 10 Ml, Lidokainijev Klorid

Otolin 10 ml

SESTAVA

Otolin kapljice vsebujejo etakridinijev laktat in lidokainijev klorid. Pomozne snovi glicerol, precišcena voda in propilenglikol.

PAKIRANJE

Škatla z 10 ml raztopine v kapalni plastenki.

DELOVANJE

Etakridinijev laktat deluje antisepticno, lidokainijev klorid pa je lokalni anestetik in blazi bolecino. Otolin kapljice blazijo bolecine v ušesu ob vnetju.

ODMERJANJE

Odrasli si vkapajo 4 do 5-krat dnevno 3 kapljice v obolelo uho. Otroci pa 2 do 3-krat dnevno 1 do 2 kapljici v obolelo uho po predhodnem posvetu z zdravnikom ali s farmacevtom.

PREVIDNOSTNI UKREPI IN OPOZORILA

Pri mocnejših bolecinah v ušesih je potreben posvet z zdravnikom. Otolin ni primeren za dolgotrajno uporabo. Otolin vsebuje propilenglikol, ki lahko povzroci drazenje koze.

Otolin shranjujte dobro zaprto pri temperaturi do 25 °C. Otolin se izdaja brez recepta v lekarnah. Za vec informacij nas obiscite v Dolenjskih lekarnah. Najblizjo lekarno lahko najdete tukaj

Deli vsebino s svojimi prijatelji

Oglejte si tudi

Ovelquin

OVELQUIN® está indicado para el tratamiento de adultos mayores de 18 años con infecciones leves, moderadas y severas causadas por microorganismos sensibles, como:

Sinusitis maxilar aguda debida a Streptococcus pneumo­­niae, Haemophilus influenzae o Moraxella catarrhalis.

Exacerbación bacteriana aguda de bronquitis crónica debida a: Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae, Haemophilus parain­fluenzae o Moraxella catarrhalis.

Neumonía adquirida en la comunidad debida a: Staphylo­co­ccus aureus, Streptococcus pneumoniae, Haemophilus influenzae, Haemophilus parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis, Chlamydia pneu­mo­niae, Legionella pneumophilia o Mycoplasma pneu­moniae.

Infecciones no complicadas de la piel y sus estructuras (de leve a moderado) incluyendo abscesos, celulitis, furunculosis, impétigo, piodermia debido a Staphylococcus aureus o Streptococcus pyogenes.

Infecciones del tracto urinario complicadas (leve a moderada) debido a: Enterococcus faecalis, Enterobacter cloacae, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis o Pseudomona aeruginosa.

Pielonefritis aguda (leve a moderada) causada por: Escherichia coli.

Infecciones del tracto urinario no complicadas (leve a moderada) debido a Escherichia coli, Klebsiella pneumoniae o Staphylococcus saprophyticus.

FARMACOCIN?TICA Y FARMACODINAMIA

El levofloxacino es rápida y casi completamente absorbido después de su administración oral. La concentración plasmática pico se alcanza usualmente en una a dos horas después de la dosis oral. La biodisponibilidad absolu­ta de una tableta de 500 mg y de 750 mg de levofloxacino es para ambas de 99%, lo que demuestra su casi completa absorción oral.

La farmacocinética del levofloxacino es lineal y predecible después de una dosis o múltiples dosis orales; las condiciones de estado estable se alcanzan en 48 horas después de una dosis de 500 ó 750 mg una vez al día. La administración oral de 500 mg de levofloxacino con los alimentos prolonga el tiempo de la concentración por aproximadamente 1 hora y disminuye la concentración pico en aproximadamente 14% en las tabletas.

Por lo tanto, las tabletas de levofloxacino se pueden administrar independientemente de los alimentos. El levofloxacino tiene una amplia distribución hacia los te­jidos. El levoflo­xacino alcanza sus niveles pico en los te­jidos de la piel y líquidos en aproximadamente 3 horas después de la dosis. In vitro, las concentraciones séricas/plasmáticas de levofloxacino están unidas a las proteínas plasmáticas en aproximadamente un 24 a 38%. El levofloxacino está unido principalmente a la albúmina sérica.

Es estable en plasma y orina y no se convierte metabólicamente a su enantiómero D-oflo­xacin. El levofloxacino sufre un limitado metabolismo y es excretado primariamente como fár­maco sin cambio por la orina. Después de la administración oral, aproximadamente el 87% de la dosis administrada es recobrada sin cambio en la orina dentro de las siguientes 48 horas, mientras que menos del 4% de la dosis es recuperada en heces en 72 horas. Menos del 5% de la dosis administrada fue recuperada en la orina como metabolitos desmetilados y N-óxido, únicos metabolitos identificados en los humanos.

El levofloxacino es excretado generalmente sin cambio en la orina. La vida media de eliminación plasmática terminal de levofloxacino oscila entre 6 a 8 horas después de una dosis única o múltiple. La depuración corporal total promedio y depuración renal es de aproximadamente 144 a 226 ml/min y 96 a 142 ml/min, respectivamente. La actividad antibacteriana de levofloxacino reside primariamente en el L-isómero. El mecanismo de acción del levofloxacino al igual que otras fluoroquinolonas involucra la inhibición de la topoisomerasa IV y DNA girasa bacteriana (ambas son del tipo II topoisomerasas), enzimas requeridas para la replicación, transcripción, reparación y recombinación del DNA.

El levofloxacino está contraindicado en personas con historia o hipersensibilidad al levofloxacino, agentes antimicrobianos quinolónicos, o a cualquier otro componente de este medicamento.

Debe administrarse con precaución en pacientes con presencia de insuficiencia renal, ya que la eliminación del levofloxacino se puede reducir. Reacciones de moderada a severa fototoxicidad se han presentado en pacientes expuestos a la luz del sol, por lo que la exposición al sol debe ser disminuida o evitada.

Como con otras quinolonas, el levofloxacino debe ser usado con precaución en pacientes con alteraciones del SNC conocidas o sospecha de éstas que pueden predis­poner a convulsiones o disminución del umbral a éstas.

Algunas quinolonas han sido asociadas con prolongación del intervalo QT en el electrocardiograma y en casos infrecuentes arritmias. Como con cualquier otro antimicrobiano potente, evaluaciones periódicas de las funciones de los sistemas, incluyendo renal, hepático y hematopoyético son recomendadas durante la terapia.

RESTRICCIONES DE USO DURANTE EL EMBARAZO Y LA LACTANCIA

No existen estudios adecuados bien controlados en mujeres embarazadas. Por lo ­tanto, el levofloxacino debe ser usado durante el embarazo únicamente si los efectos benéficos potenciales justifican los riesgos potenciales al feto.

Se presume que el levofloxacino puede ser excretado en la leche humana. Debido al potencial de reacciones adversas severas del levofloxacino en lactantes, se debe tomar la decisión de descontinuar la ingesta del medicamento.

REACCIONES SECUNDARIAS Y ADVERSAS

La in­ciden­cia de reacciones adversas relacionadas al medicamento es de 6.2% entre los pacientes que reciben levoflo­xacino, y solamente el 4.3% descontinúan el tra­ta­miento debido a estas reacciones adversas. La incidencia general, tipo y distribución de los eventos adversos fue similar en los pacientes que recibieron dosis de 750 mg una vez al día comparado con los pacientes que reciben dosis de 250 a 500 mg una o dos veces al día. Los siguientes eventos adversos están ­relacionados directamente con el medicamento: náusea 1.2%, diarrea 1.0%, vaginitis 0.6%, insomnio 0.4%, dolor abdo­minal 0.4%, flatulencia 0.3%, prurito 0.3%, mareo 0.3%, rash 0.3%, dispepsia 0.2%, moniliasis vaginal 0.2%, moniliasis 0.2%, alteraciones del sabor 0.2%, vómito 0.2%, constipación 0.1%, infecciones ­micóticas 0.1%, prurito general 0.1%, cefalea 0.1%, nerviosismo 0.1%, rash eritematoso 0.1%, urticaria 0.1%, anorexia 0.1%, somnolencia 0.1%,

INTERACCIONES MEDICAMENTOSAS Y DE OTRO G?NERO

La administración concomitante con cimetidina y/o probenecid produce aproximadamente un 24% y 35% de reducción en la depuración renal de levofloxacino, respectivamente, lo que indica que la secreción de levofloxacino ocurre en el túbulo proximal renal.

Otras potenciales interacciones medicamentosas farmacocinéticas pueden ocurrir entre levofloxacino y teofilina, warfarina, ciclosporina, digoxina, la administración concurrente de OVELQUIN® con antiácidos ­conteniendo calcio, magnesio o aluminio, asi como también sucralfato, cationes metálicos como hierro y preparaciones de multivitaminas como zinc pueden interferir con la absorción gastrointestinal de levofloxacino, ­obteniendo niveles sericos y en orina más bajos que los deseados. Estos agentes pueden ser tomados por lo menos 2 ­horas antes o 2 horas después de la administración de levofloxacino.

ALTERACIONES EN LOS RESULTADOS DE PRUEBAS DE LABORATORIO

Como con otras quinolonas se han reportado alteraciones de la glucosa sanguínea, incluyendo hiper e hipoglucemia sintomática, usualmente en pacientes diabéticos que reciben agentes hipoglucemiantes orales o insulina.

PRECAUCIONES EN RELACI?N CON EFECTOS DE CARCINOG?NESIS, MUTAG?NESIS, TERATOG?NESIS Y SOBRE LA FERTILIDAD

En estudios a largo plazo sobre carcinogenicidad en ratas, el levofloxacino no exhibe potencial carcinogénico después de la administración diaria durante 2 años, las dosis diarias más elevadas empleadas fueron de 2-10 veces la dosis recomendada en seres humanos.

El levofloxacino no ha mostrado efecto mutagénico en los siguientes estudios: estudio de mutación bacte­riana Ames, CHO/HGPRT, prueba de micronúcleos en ratón y en la prueba de intercambio de cromátides en ratones hermanas.

El levofloxacino no causa alteraciones sobre la fertilidad o capacidad reproductiva en ratas con dosis orales de 360 mg/kg/día.

DOSIS Y V?A DE ADMINISTRACI?N

MANIFESTACIONES Y MANEJO DE LA SOBREDOSIFICACI?N O INGESTA ACCIDENTAL

OVELQUIN® exhibe un bajo potencial para toxicidad aguda. Se pue­den presentar los siguientes signos clínicos después de recibir una dosis muy elevada de levofloxacino: ataxia, ptosis, disminución de la actividad motora, disnea, postración, tremor y convulsiones.

En caso de una sobredosificación se debe provocar el vómito o realizar un lavado gástrico. El paciente debe ser observado y mantener una hidratación adecuada e instaurar un tratamiento sintomático. El levofloxacino no es eficientemente eliminado por hemodiálisis o por diálisis peritoneal.

Caja con 7 tabletas de 500 mg.

Caja con 7 tabletas de 750 mg.

RECOMENDACIONES SOBRE ALMACENAMIENTO

Consérvese a temperatura ambiente a no más de 30°C y en lugar seco.

LEYENDAS DE PROTECCI?N

Su venta requiere receta médica. No se administre durante el embarazo, la lactancia, ni a menores de 18 años. No se deje al alcance de los niños. Literatura exclusiva para médicos.

PROBIOMED, S. A. de C. V.

Reg. Núm. 491M2005, SSA IV

Dozilax, Dozilax

Tag Archives: Dozilax

Donepezil is a centrally acting reversible acetylcholinesterase inhibitor. Donepezil is used to treat dementia (a brain disorder that affects the ability to remember, think clearly, communicate, and perform daily activities and may cause changes in mood and personality) associated with Alzheimer’s disease (a brain disease that slowly destroys the memory and the ability to think, learn, communicate and handle daily activities). It improves mental function (such as memory, attention, social interaction, reasoning and language abilities, and ability to perform activities of daily living) by increasing the amount of a certain naturally occurring substance in the brain. Donepezil may improve the ability to think and remember or slow the loss of these abilities in people who have Alzheimer’s disease. However, donepezil will not cure Alzheimer’s disease or prevent the loss of mental abilities at some time in the future.

Donepezil

Brand names:

A Rui Si, Alcept, Alchphil, Aldemiz, Aldigmod, Aldocept, Aldomer, Alzaimax, Alzancer, Alzdone, Alzepezil, Alzepil, Alzepil, Alzil, Alzim, Ameloss, Andepezil, Apezil, Apo-Donepezil, Apo-Doperil, Arcdone, Aricept, Aricept, Aricept D. A.C. Aricept Evess, Aricept Evess, Aricept Flas, Aridone, Ariknow, Aripez, Aripezil, Arypez, Asenta, Brencept, Calofra, Carencil, Carrier Plus (Donepezil and Memantine), Cebrocal, Ceptpezil, Cogiton, Cognezil, Cristaclar, Davia, Dazolin, Dement, Dentap, Depzil, Dimenta, Divare, Dizil, Doenza, Doenza-Sanovel, Domentac, Donecept, Donecept, Donecil, Donecleus, Donef, Donelet, Donelinn, Donemed, Donepecilo Richet, Donepes, Donepex, Donepex, Donepezil, Donepezil +pharma, Donepezil Accord, Donepezil Actavis, Donepezil Actavis, Donepezil Actavis ODT, Donepezil bluefish, Donepezil Genericon, Donepezil Generics, Donepezil Gerolymatos, Donepezil HCl Daewon, Donepezil HCl Hanlim, Donepezil Helvepharm, Donepezil Hydrochloride, Donepezil Hydrochloride Accord, Donepezil Hydrochloride Actavis, Donepezil Hydrochloride Apotex, Donepezil Hydrochloride Aurobindo, Donepezil Hydrochloride Barr, Donepezil Hydrochloride Cipla, Donepezil Hydrochloride Dr. Reddy’s, Donepezil Hydrochloride Hikma, Donepezil Hydrochloride Huahai, Donepezil Hydrochloride Jubilant, Donepezil Hydrochloride Matrix, Donepezil Hydrochloride Pliva, Donepezil Hydrochloride Ranbaxy, Donepezil Hydrochloride Roxane, Donepezil Hydrochloride Sandoz, Donepezil Hydrochloride Sun, Donepezil Hydrochloride Teva, Donepezil Hydrochloride Torrent, Donepezil Hydrochloride Wockhardt, Donepezil Hydrochloride Zydus, Donepezil Krka, Donepezil LPH, Donepezil Mylan, Donepezil Nucleus, Donepezil ODT, Donepezil Orifarm, Donepezil Orion, Donepezil Pliva, Donepezil Ratiopharm, Donepezil Rex, Donepezil Sandoz, Donepezil Synthon, Donepezil Synthon, Donepezil Teva, Donepezilijev klorid Mylan, Donepezilijev klorid Nucleus, Donepezilijev klorid Teva, Donepezil-Mepha, Donepezilo Farmoz, Donepezilo Generis, Donepezil-Teva, Doneratio, Donester, Donesyn, Donesyn, Donezil, Donopez, Donpethon, Dopaben, Dopezil, Dozept, Dozilax, Dozyl, Dozylen, Elzer, Endoclar, Epalon, Eranz, Eranz, Evimal, Fang Qing, Fincip, Fordesia, Fu Si Ke, Gai Fei, Garmisch Glix, Hania, Hicept, Iania, Jia Qi, Kibilis, Landex, Lirpan, Memac, Memac Orifarm, Memac Paranova, Memofit, Memorin, Nepes, Nepezil, Neurem, Neuropezil, Neutoin, Nomi-Nox, Nuo Chong, Oldinot, Onefin, Pezale, Pridia, Redumas, Remecin, Rewise, Si Bo Hai, Silversept, Symepezil, Synpezil, Tuadin, Valpex, Varopezil, Vastia, Whanin Donepezil, Yasnal, Yasnal, Zhedon, Zolpezil,

Side effects:

Donepezil uses:

Treatment of Alzheimer’s Disease, Lewy Body Dementia and Mild Cognitive Impairment.

Autism, traumatic brain injury, vascular dementia, poststroke aphasia, improvement in memory in multiple sclerosis patients.

Oral Mild to moderately severe dementia in Alzheimer’s disease Adult: Initially, 5 mg daily at bedtime, increase if necessary up to 10 mg once daily at bedtime after 4-6 weeks.

Elderly: Initially, 5 mg daily at bedtime, increase if necessary up to 10 mg once daily at bedtime after 4-6 weeks.

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Aricept is used for treating dementia (eg, impairment of memory, judgment, and abstract thinking; changes in personality) in patients with Alzheimer disease. Aricept is a cholinesterase inhibitor. It works by increasing the amount of a certain substance (acetylcholine) in the brain, which may help reduce the symptoms of dementia in patients with Alzheimer disease.

Use Aricept as directed by your doctor.

Take Aricept by mouth in the evening right before bed, unless your doctor tells you otherwise. Take Aricept with or without food.

Take Aricept on a regular schedule to get the most benefit from it.

Taking Aricept at the same time each day will help you remember to take it.

Continue to take Aricept even if you feel well. Do not miss any dose.

If you miss a dose of Aricept, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Contact your doctor if you miss several doses of Aricept. You may need to restart your medicine at a lower dose to avoid side effects.

Ask your health care provider any questions you may have about how to use Aricept.

Store Aricept at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Aricept out of the reach of children and away from pets.

Active Ingredient: Donepezil.

Do NOT use Aricept if:

you are allergic to any ingredient in Aricept.

Some medical conditions may interact with Aricept. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of certain heart problems (eg, slow or irregular heartbeat, sick sinus syndrome), stomach or bowel problems (eg, ulcer, blockage), lung or breathing problems (eg, asthma, chronic obstructive pulmonary disease [COPD]), or urinary blockage

if you have brain lesions or tumors, increased pressure in the brain, recent head injury, or a history of seizures (eg, epilepsy)

if you have Parkinson disease or metabolism problems.

Some medicines may interact with Aricept. Tell your health care provider if you are taking any other medicines, especially any of the following:

Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen) because the risk of stomach or bowel bleeding may be increased

Cholinergic agents (eg, bethanechol), cholinesterase inhibitors (eg, galantamine), or ketoconazole because they may increase the risk of Aricept's side effects

Carbamazepine, dexamethasone, phenobarbital, phenytoin, or rifampin because they may decrease Aricept's effectiveness

Anticholinergics (eg, scopolamine) because their effectiveness may be decreased by Aricept.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Aricept may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Aricept may cause drowsiness, dizziness, or fainting. These effects may be worse if you take it with alcohol or certain medicines. Use Aricept with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Do not take more than the recommended dose without checking with your doctor.

Tell your doctor or dentist that you take Aricept before you receive any medical or dental care, emergency care, or surgery.

Aricept is not approved for use in children; safety and effectiveness in children have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Aricept while you are pregnant. It is not known if Aricept is found in breast milk. Aricept is not approved for use in women who may be breast-feeding.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Abnormal dreams; diarrhea; dizziness; loss of appetite; muscle cramps; nausea; tiredness; trouble sleeping; vomiting; weight loss.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody or black, tarry stools; chest pain; decreased urination; depression; fainting; fever; seizures; severe dizziness or headache; shortness of breath; slow or irregular heartbeat; swelling of the hands, ankles, or feet; unusual bruising; tremor.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Piroxicam Medlineplus Drug Information, Feldegel

Piroxicam

People who take nonsteroidal anti-inflammatory medications (NSAIDs) (other than aspirin) such as piroxicam may have a higher risk of having a heart attack or a stroke than people who do not take these medications. These events may happen without warning and may cause death. This risk may be higher for people who take NSAIDs for a long time. Do not take an NSAID such as piroxicam if you have recently had a heart attack, unless directed to do so by your doctor. Tell your doctor if you or anyone in your family has or has ever had heart disease, a heart attack, or a stroke, if you smoke, and if you have or have ever had high cholesterol, high blood pressure, or diabetes. Get emergency medical help right away if you experience any of the following symptoms: chest pain, shortness of breath, weakness in one part or side of the body, or slurred speech.

If you will be undergoing a coronary artery bypass graft (CABG; a type of heart surgery), you should not take piroxicam right before or right after the surgery.

NSAIDs such as piroxicam may cause ulcers, bleeding, or holes in the stomach or intestine. These problems may develop at any time during treatment, may happen without warning symptoms, and may cause death. The risk may be higher for people who take NSAIDs for a long time, are older in age, have poor health, or drink large amounts of alcohol while you are taking piroxicam. Tell your doctor if you take any of the following medications: anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); aspirin; other NSAIDs such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); oral steroids such as dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos); selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), fluoxetine (Prozac, Sarafem, Selfemra, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft); or serotonin norepinephrine reuptake inhibitors (SNRIs) such as desvenlafaxine (Khedezla, Pristiq), duloxetine (Cymbalta), and venlafaxine (Effexor XR). Also tell your doctor if you have or have ever had ulcers or bleeding in your stomach or intestines or other bleeding disorders. If you experience any of the following symptoms, stop taking piroxicam and call your doctor: stomach pain, heartburn, vomiting a substance that is bloody or looks like coffee grounds, blood in the stool, or black and tarry stools.

Keep all appointments with your doctor and the laboratory. Your doctor will monitor your symptoms carefully and will probably order certain tests to check your body's response to piroxicam. Be sure to tell your doctor how you are feeling so that your doctor can prescribe the right amount of medication to treat your condition with the lowest risk of serious side effects.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with piroxicam and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www. fda. gov/Drugs/DrugSafety/ucm085729.htm ) or the manufacturer's website to obtain the Medication Guide.

Why is this medication prescribed?

Piroxicam is used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints) and rheumatoid arthritis (arthritis caused by swelling of the lining of the joints). Piroxicam is in a class of medications called NSAIDs. It works by stopping the body's production of a substance that causes pain, fever, and inflammation.

How should this medicine be used?

Piroxicam comes as a capsule to take by mouth. It is usually taken once or twice a day. Take piroxicam at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take piroxicam exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Piroxicam will help control your symptoms but will not cure your condition. It may take 8 to 12 weeks or longer before you feel the full benefit of piroxicam.

Other uses for this medicine

Piroxicam is also sometimes used to treat gouty arthritis (attacks of severe joint pain and swelling caused by a build-up of certain substances in the joints) and ankylosing spondylitis (arthritis that mainly affects the spine). It is also sometimes used to relieve muscle pain and swelling, menstrual pain, and pain after surgery or childbirth. Talk to your doctor about the risks of using this medication for your condition.

What special precautions should I follow?

Before taking piroxicam,

tell your doctor and pharmacist if you are allergic to piroxicam, aspirin, or other NSAIDs such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn), any other medications, or any of the inactive ingredients in piroxicam capsules. Ask your pharmacist for a list of the inactive ingredients.

tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin, in Lotrel), captopril, enalapril (Vasotec, in Vaseretic), fosinopril, lisinopril (in Zestoretic), moexipril (Univasc), perindopril (Aceon, in Prestalia), quinapril (Accupril, in Quinaretic), ramipril (Altace), and trandolapril (Mavik, in Tarka); angiotensin receptor blockers (ARBs) such as azilsartan (Edarbi, in Edarbyclor), candesartan (Atacand, in Atacand HCT), eprosartan (Teveten), irbesartan (Avapro, in Avalide), losartan (Cozaar, in Hyzaar), olmesartan (Benicar, in Azor, in Benicar HCT, in Tribenzor), telmisartan (Micardis, in Micardis HCT, in Twynsta), and valsartan (in Exforge HCT); beta blockers such as atenolol (Tenormin, in Tenoretic), labetalol (Trandate), metoprolol (Lopressor, Toprol XL, in Dutoprol), nadolol (Corgard, in Corzide), and propranolol (Hemangeol, Inderal, Innopran); diuretics ('water pills'); lithium (Lithobid); medications for diabetes; methotrexate (Otrexup, Rasuvo, Trexall); and phenytoin (Dilantin, Phenytek). Your doctor may need to change the doses of your medication or monitor you more carefully for side effects.

tell your doctor if you have or have ever had asthma, especially if you also have frequent stuffy or runny nose or nasal polyps (swelling of the lining of the nose); heart failure; swelling of the hands, feet, ankles, or lower legs ; or liver, or kidney disease.

tell your doctor if you are pregnant, especially if you are in the last few months of your pregnancy, you plan to become pregnant, or you are breastfeeding. If you become pregnant while taking piroxicam, call your doctor.

talk to your doctor about the risks and benefits of taking piroxicam if you are 65 years of age or older. Older adults should usually take lower doses of piroxicam for short periods of time because higher doses taken regularly may not be more effective and are more likely to cause serious side effects.

if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking piroxicam.

What special dietary instructions should I follow?

Piroxicam may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

Some side effects can be serious. If you experience any of the following symptoms or those mentioned in the IMPORTANT WARNING section, call your doctor immediately. Do not take any more piroxicam until you speak to your doctor.

vision problems

unexplained weight gain

shortness of breath or difficulty breathing

swelling in the abdomen, ankles, feet, or legs

fever

blisters

joint pain

rash

itching

hives

swelling of the eyes, face, lips, tongue, throat, arms, or hands

difficulty breathing or swallowing

hoarseness

pale skin

fast heartbeat

excessive tiredness

unusual bleeding or bruising

lack of energy

upset stomach

loss of appetite

pain in the upper right part of the stomach

flu-like symptoms

yellowing of the skin or eyes

cloudy, discolored, or bloody urine

back pain

difficult or painful urination

Piroxicam may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www. fda. gov/Safety/MedWatch ) or by phone (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo. gl/c4Rm4p ) for more information if you do not have access to a take-back program.

In case of emergency/overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Symptoms of overdose may include the following:

lack of energy

drowsiness

upset stomach

vomiting

stomach pain

bloody, black, or tarry stools

vomiting a substance that is bloody or looks like coffee grounds

difficulty breathing

coma (loss of consciousness for a period of time)

What other information should I know?

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand names

Buy Di Retard Retard - Fda Approved Prescription Drug At, Di Retard

FAQ. How to buy Di Retard Retard without Prescription Drugs? Q. Where is your drugstore situated? A. We have branches all over the world: in the south of the Pacific ocean, Europe and Middle East. All will depend on Di Retard Retard which you have ordered, manufacturer and from the wholesale seller who delivers Di Retard Retard.

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Q. Do I need a Di Retard Retard prescription to order a medicine? A. No, you do not. The recipe on Di Retard Retard is not necessary for you. We work under the laws of those countries from which we make dispatches.

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Mylac, Mylac

Mylac

Important Notice: The Drugs. com international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

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Louisiana Health Cooperative, Inc. in Rehabilitation (LAHC) is operating under a Permanent Order of Rehabilitation entered on September 21, 2015 by the 19th Judicial District Court, Baton Rouge, Louisiana. The Louisiana Insurance Commissioner was appointed by the Court as Rehabilitator and Billy Bostick as Receiver of LAHC. All LAHC policies terminated on December 31, 2015 by order of the court.

LEGAL NOTICE is hereby given that any and all claims against LAHC MUST BE FILED BY MARCH 31, 2016.

ANY CLAIM RECEIVED AFTER MARCH 31, 2016 will be considered untimely and will not be paid until all timely filed claims are paid.

All required premiums, deductibles, co-payments and co-insurance payments must be paid in full. If your coverage terminates, you will be fully responsible for the cost of health services that you received after the termination date.

For more information, including the Order of Rehabilitation, visit the Louisiana Department of Insurance website.

If you have any questions about your contractual obligations, please contact:

Louisiana Health Cooperative, Inc. (LAHC) in Receivership

3445 North Causeway Blvd.

Prednisolone Ophthalmic Medlineplus Drug Information, Prednisolonum

Prednisolone Ophthalmic

Ophthalmic prednisolone comes as a solution (liquid) and a suspension (eye drops) to instill in the eye and as an eye ointment to apply to the eye. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use prednisolone eye drops or eye ointment exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.

Continue to use prednisolone eye drops or eye ointment even if you feel well. Do not stop using prednisolone eye drops or eye ointment without talking to your doctor.

To use the eye drops, follow these instructions:

Wash your hands thoroughly with soap and water.

Check the label on your bottle to see if you should shake the eye drops before using. Shake the bottle well if the label says that you should

Check the dropper tip to make sure that it is not chipped or cracked.

Avoid touching the dropper tip against your eye or anything else; eye drops and droppers must be kept clean.

While tilting your head back, pull down the lower lid of your eye with your index finger to form a pocket.

Hold the dropper (tip down) with the other hand, as close to the eye as possible without touching it.

Brace the remaining fingers of that hand against your face.

While looking up, gently squeeze the dropper so that a single drop falls into the pocket made by the lower eyelid. Remove your index finger from the lower eyelid.

Close your eye for 2 to 3 minutes and tip your head down as though looking at the floor. Try not to blink or squeeze your eyelids.

Place a finger on the tear duct and apply gentle pressure.

Wipe any excess liquid from your face with a tissue.

If you are to use more than one drop in the same eye, wait at least 5 minutes before instilling the next drop.

Replace and tighten the cap on the dropper bottle. Do not wipe or rinse the dropper tip.

Wash your hands to remove any medication.

Toapply the eye ointment, follow these steps:

Wash your hands thoroughly with soap and water.

Use a mirror or have someone else apply the ointment.

Avoid touching the tip of the tube against your eye or anything else. The ointment must be kept clean.

Tilt your head forward slightly.

Holding the tube between your thumb and index finger, place the tube as near as possible to your eyelid without touching it.

Brace the remaining fingers of that hand against your cheek or nose.

With the index finger of your other hand, pull the lower lid of your eye down to form a pocket.

Place a small amount of ointment into the pocket made by the lower lid and the eye. A 1/2-inch (1.25-centimeter) strip of ointment usually is enough unless otherwise directed by your doctor.

Gently close your eyes and keep them closed for 1 to 2 minutes to allow the medication to be absorbed.

Replace and tighten the cap right away.

Wipe off any excess ointment from your eyelids and lashes with a clean tissue. Wash your hands again.

Your vision may be blurry for a short amount of time after using the eye ointment. Wait until you can see normally before you drive or do other activities that require good vision.

Other uses for this medicine

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before using prednisolone eye drops or eye ointment,

tell your doctor and pharmacist if you are allergic to prednisolone or any other drugs.

tell your doctor and pharmacist what prescription and nonprescription medications you are taking, including vitamins.

tell your doctor if you have or have ever had glaucoma or diabetes.

tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while using prednisolone eye drops or eye ointment, call your doctor immediately.

What should I do if I forget a dose?

Instill or apply the missed dose as soon as you remember it. Use any remaining doses for that day at evenly spaced intervals. However, if you remember a missed dose at the time the next one is due, use only the regularly scheduled dose. Do not instill or apply a double dose to make up for a missed one.

What side effects can this medication cause?

Prednisolone eye drops and eye ointment may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

temporary eye burning or stinging

temporary blurred vision

Some side effects can be serious. If you experience the following symptom, call your doctor immediately:

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www. fda. gov/Safety/MedWatch ) or by phone (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

What other information should I know?

Keep all appointments with your doctor.

Do not let anyone else use your medication. Ask your pharmacist any questions you have about refilling your prescription.

If you still have symptoms of eye irritation after you finish the prednisolone eye drops or eye ointment, call your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand names

Brand names of combination products

Blephamide ® (containing Prednisolone, Sulfacetamide)

Isopto Cetapred ® (containing Prednisolone, Sulfacetamide) ¶

Metimyd ® (containing Prednisolone, Sulfacetamide) ¶

Poly-Pred ® (containing Neomycin, Polymyxin B, Prednisolone)

Pred-G ® (containing Gentamicin, Prednisolone)

Predamide ® (containing Prednisolone, Sulfacetamide) ¶

Predsulfair ® (containing Prednisolone, Sulfacetamide) ¶

Sulphrin ® (containing Prednisolone, Sulfacetamide) ¶

Sulster ® (containing Prednisolone, Sulfacetamide) ¶

Vasocidin ® (containing Prednisolone, Sulfacetamide)

¶ This branded product is no longer on the market. Generic alternatives may be available.

Last Revised - 05/16/2011

American Society of Health-System Pharmacists, Inc. Disclaimer

AHFS ® Patient Medication Information. © Copyright, 2016. The American Society of Health-System Pharmacists, Inc. 7272 Wisconsin Avenue, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.

Rufen - Symptoms, Treatments And Resources For Rufen, Rufen

Rufen

Drug Name: IBUPROFEN - ORAL

Other Brand Names: Advil, Motrin, Nuprin

Uses: Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID), which relieves pain and swelling (inflammation). It is used to treat headaches, muscle aches, backaches, dental pain, menstrual cramps, arthritis, or athletic injuries. This medication is also used to reduce fever and to relieve minor aches and pains due to the common cold or flu. This drug works by blocking the enzyme in your body that makes prostaglandins. Decreasing prostaglandins helps to reduce pain, swelling, and fever.

Posts on Rufen (1)

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Acebel P Tablet - Uses, Side-Effects, Reviews, Composition, Interactions, Precautions, Substitutes,

Acebel P Tablet

Acebel P Tablet - Uses, Composition, Side Effects and Reviews

Acebel P Tablet is indicated for the treatment of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, headache, toothache, ear pain and other conditions. Acebel P Tablet contains the following active ingredients: Aceclofenac, Paracetamol. It is available in tablet form. Blubell Pharma manufactures Acebel P Tablet. Detailed information related to Acebel P Tablet's uses, composition, dosage, side effects and reviews is listed below:

Acebel P Tablet Uses

Acebel P Tablet is used in the treatment, control, prevention, & improvement of the following diseases, conditions and symptoms:

Learn more: Uses (in more detail)

Acebel P Tablet Working, Mechanism of Action and Pharmacology

Acebel P Tablet improves the patient's condition by performing the following functions:

Decreasing the chemical substances in the body.

Increasing the pain threshold and increases the blood flow across the skin, heat loss and sweating.

Acebel P Tablet Composition and Active Ingredients

Acebel P Tablet is composed of the following active ingredients (salts)

Please note that this medicine may be available in various strengths for each active ingredient listed above.

Acebel P Tablet Side-effects

The following is a list of possible side effects that may occur from all constituting ingredients of Acebel P Tablet. This is not a comprehensive list. These side effects are possible, but do not always occur. Some of the side effects may be rare but serious. Consult your doctor if you observe any of the following side effects, especially if they do not go away.

If you notice other side effects not listed above, contact your doctor for medical advice. You may also report side effects to your local food and drug administration authority.

Learn more: Side-effects (in more detail)

Acebel P Tablet Precautions & How to Use

Before using this drug, inform your doctor about your current list of medications, over the counter products (e. g. vitamins, herbal supplements, etc.), allergies, pre-existing diseases, and current health conditions (e. g. pregnancy, upcoming surgery, etc.). Some health conditions may make you more susceptible to the side effects of the drug. Take as directed by your doctor or follow the direction printed on the product insert. Dosage is based on your condition. Tell your doctor if your condition persists or worsens. Important counseling points are listed below.

Alcohol

Avoid using it if allergic to paracetamol

Consult your doctor if you are suffering from crohn's disease, kidney disease, gastrointestinal disease, blood clotting problems, systemic lupus erythematosus, metabolism disturbances

Do not operate machinery or drive

Do not take paracetamol if you consume alcoholic beverages every day

Elderly

Learn more: Precautions & How to Use (in more detail)

Acebel P Tablet Frequently asked Questions

Can Acebel P Tablet be used for Osteoarthritis and Rheumatoid arthritis?

Yes, osteoarthritis and rheumatoid arthritis are among the most common reported uses for Acebel P Tablet. Please do not use Acebel P Tablet for osteoarthritis and rheumatoid arthritis without consulting first with your doctor. Click here to find out what other patients report as common uses for Acebel P Tablet.

Is it safe to drive or operate heavy machinery when consuming?

If you experience drowsiness, dizziness, hypotension or headache as side-effects when eating Acebel P Tablet medicine then it maybe not be safe to drive a vehicle or operate heavy machinery. One should not drive a vehicle if eating the medicine makes you drowsy, dizzy or lowers your blood-pressure extensively. Pharmacists also advise patients not to drink alcohol with medicines as alcohol intensifies drowsiness side-effects. Please check for these effects on your body when using Acebel P Tablet. Always consult with your doctor for recommendations specific to your body and health conditions.

Is this medicine or product addictive or habit forming?

Most medicines don't come with a potential for addiction or abuse. Usually, government's categorizes medicines that can be addictive as controlled substances. Examples include schedule H or X in India and schedule II-V in the US. Please consult the product package to make sure that the medicine does not belong to such special categorizations of medicines. Lastly, do not self-medicate and increase your body's dependence to medicines without the advice of a doctor.

Can it be stopped immediately or do I have to slowly ween off consumption?

Some medicines need to be tapered or cannot be stopped immediately because of rebound effects. Please consult with your doctor for recommendations specific to your body, health and other medications that you may be using.

Is Acebel P Tablet safe to consume or apply when pregnant?

Please consult with your doctor for case-specific recommendations.

Is Acebel P Tablet safe while breastfeeding?

Please discuss the risks and benefits with your doctor.

Consumer Survey: Acebel P Tablet

The following are the results of on-going survey on TabletWise. com for Acebel P Tablet. These results only indicate the perceptions of the website users. Please base your medical decisions only on the advice of a doctor or a registered medical professional.

Uses, Effectiveness and Side-effects

Following are the uses, perceived effectiveness and perceived side-effects incidence information reported by website visitor for Acebel P Tablet:

User reported uses

No data has been collected for this survey

User reported time for results

No data has been collected for this survey

Acebel P Tablet Drug Interactions

If you take other drugs or over the counter products at the same time, the effects of Acebel P Tablet may change. This may increase your risk for side effects or cause your drug not to work properly. Tell your doctor about all the drugs, vitamins, and herbal supplements you are using, so that you doctor can help you prevent or manage drug interactions. Acebel P Tablet may interact with the following drugs and products:

Alcohol

Anticoagulants

Digoxin

Diuretics

Interfere with certain laboratory tests

Juxtapid mipomersen

Learn more: Interactions (in more detail)

Acebel P Tablet Contraindications

Hypersensitivity to Acebel P Tablet is a contraindication. In addition, Acebel P Tablet should not be taken if you have the following conditions:

Allergic reaction

Bleeding or bleeding disorders

Heart attack

Hepatic impairment

Hypersensitivity

Liver failure

Learn more: Contraindications (in more detail)

Other important Information on Acebel P Tablet

Missing a dose

In case you miss a dose, take it as soon as you notice. If it is close to the time of your next dose, skip the missed dose and resume your dosing schedule. Do not take extra dose to make up for a missed dose. If you are regularly missing doses, consider setting an alarm or asking a family member to remind you. Please consult your doctor to discuss changes in your dosing schedule or a new schedule to make up for missed doses, if you have missed too many doses recently.

Overdosage of Acebel P Tablet

Do not take more than prescribed dose. Taking more medication will not improve your symptoms; rather they may cause poisoning or serious side effects. If you suspect that you or anyone else who may have overdosed of Acebel P Tablet, please go to the emergency department of the closest hospital or nursing home. Bring a medicine box, container, or label with you to help doctors with necessary information.

Do not give your medicines to other people even if you know that they have the same condition or it seems that they may have similar conditions. This may lead to overdosage.

Please consult your physician or pharmacist or product package for more information.

Storage of Acebel P Tablet

Store medicines at room temperature, away from heat and direct light. Do not freeze medicines unless required by package insert. Keep medicines away from children and pets.

Do not flush medications down the toilet or pour them into drainage unless instructed to do so. Medication discarded in this manner may contaminate the environment. Please consult your pharmacist or doctor for more details on how to safely discard Acebel P Tablet.

Expired Acebel P Tablet

Taking a single dose of expired Acebel P Tablet is unlikely to produce an adverse event. However, please discuss with your primary health provider or pharmacist for proper advice or if you feel unwell or sick. Expired drug may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to take expired drug. If you have a chronic illness that requires taking medicine constantly such as heart condition, seizures, and life-threatening allergies, you are much safer keeping in touch with your primary health care provider so that you can have a fresh supply of unexpired medications.

Dosage Information

Please consult your physician or pharmacist or refer to product package.

Quetiapine Indications, Side Effects, Warnings, Quetiap

Quetiapine

Generic Name: quetiapine (kwe-TYE-a-peen) Brand Name: Seroquel

Quetiapine is an antipsychotic. It may increase the risk of death when used to treat mental problems caused by dementia in elderly patients. Most of the deaths were linked to heart problems or infection. Quetiapine is not approved to treat mental problems caused by dementia.

Antidepressants may increase the risk of suicidal thoughts or actions in children, teenagers, and young adults. However, depression and certain other mental problems may also increase the risk of suicide. Talk with the patient's doctor to be sure that the benefits of using quetiapine outweigh the risks.

Family and caregivers must closely watch patients who take quetiapine. It is important to keep in close contact with the patient's doctor. Tell the doctor right away if the patient has symptoms like worsened depression, suicidal thoughts, or changes in behavior. Discuss any questions with the patient's doctor.

Quetiapine is not approved for use in all children. If quetiapine is prescribed for your child, talk with the doctor to be sure that quetiapine is right for your child.

Quetiapine is used for:

Treating schizophrenia or bipolar disorder. It may also be used for other conditions as determined by your doctor.

Quetiapine is an atypical antipsychotic. Exactly how it works is not known. It is thought to affect certain substances in the brain.

Do NOT use quetiapine if:

you are allergic to any ingredient in quetiapine

you have low blood potassium or magnesium levels

you have a history of certain types of irregular heartbeat (eg, QT prolongation, very slow heartbeat)

you are taking certain antiarrhythmic medicines (eg, amiodarone, procainamide, quinidine, sotalol), certain antipsychotic medicines (eg, ziprasidone), methadone, pentamidine, certain phenothiazines (eg, chlorpromazine, thioridazine), certain quinolone antibiotics (eg, moxifloxacin) or any other medicine that may increase the risk of a certain type of irregular heartbeat (prolonged QT interval). Check with your doctor or pharmacist if you are unsure if any of your medicines may increase the risk of this type of irregular heartbeat

Contact your doctor or health care provider right away if any of these apply to you.

Before using quetiapine:

Some medical conditions may interact with quetiapine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you or a family member has a history of suicidal thoughts or attempts, bipolar disorder (manic depression) or other mental or mood problems, a certain type of irregular heartbeat (prolonged QT interval), or diabetes or high blood sugar

if you drink alcohol or have a history of alcohol or substance abuse

if you have Alzheimer disease, dementia, poor health, or trouble swallowing, or you are very overweight

if you are dehydrated, have low blood volume, or will be exposed to very high temperatures

if you have a history of a heart attack or other heart problems (eg, enlargement of the heart, heart failure, irregular heartbeat), stroke, blood vessel problems (eg, in the brain), high blood cholesterol or triglyceride levels, or high or low blood pressure

if you have a history of low white blood cell levels, including low levels caused by medicine; kidney, liver, or pancreas problems; stomach or bowel problems; thyroid problems; cataracts; narrow-angle glaucoma; seizures; neuroleptic malignant syndrome (NMS); gallstones; or low blood magnesium or potassium levels

if you have had high blood prolactin levels or a history of certain types of cancer (eg, breast, pancreas, pituitary, brain), or if you are at risk of breast cancer

if you take medicines that may harm the liver (eg, acetaminophen, methotrexate, ketoconazole, isoniazid, certain medicines for HIV infection). Ask your doctor if you are unsure if any of your medicines might harm the liver

Some MEDICINES MAY INTERACT with quetiapine. Tell your health care provider if you are taking any other medicines, especially any of the following:

Many prescription and nonprescription medicines (eg, used for cancer, depression or other mental or mood problems, hepatitis C, high blood pressure, HIV, infections, inflammation, irregular heartbeat or other heart problems, narcotic abuse or dependence, nausea or vomiting, pain, Parkinson disease, restless legs syndrome, seizures, stomach or bowel problems, trouble sleeping), multivitamin products, or herbal or dietary supplements (eg, herbal teas, coenzyme Q10, garlic, ginseng, ginkgo, St. John's wort) because they may interact with quetiapine. Ask your doctor or pharmacist if you are unsure if any of your medicines might interact with quetiapine

This may not be a complete list of all interactions that may occur. Ask your health care provider if quetiapine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use quetiapine:

Use quetiapine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Quetiapine comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get quetiapine refilled.

Take quetiapine by mouth with or without food.

Continue to take quetiapine even if you feel well. Do not miss any doses.

Taking quetiapine at the same times each day will help you to remember to take it.

Do not suddenly stop taking quetiapine without first talking with your doctor. You may have an increased risk of side effects. If you need to stop quetiapine, your doctor will gradually lower your dose.

If you miss a dose of quetiapine, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. If you miss taking quetiapine for longer than 1 week, contact your doctor before you start to take it again. Your dose may need to be adjusted.

Ask your health care provider any questions you may have about how to use quetiapine.

Important safety information:

Quetiapine may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use quetiapine with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

Do not drink alcohol while you are using quetiapine.

Check with your doctor before you use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using quetiapine; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.

Quetiapine may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. This may be more likely to occur when you start to take quetiapine and also if your dose increases. To prevent these effects, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.

Do not become overheated or dehydrated in hot weather or while you are being active; heatstroke, dizziness, or fainting may occur.

Several weeks may pass before your symptoms improve. Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.

Children, teenagers, and young adults who take quetiapine may be at increased risk for suicidal thoughts or actions. Watch all patients who take quetiapine closely. Contact the doctor at once if new, worsened, or sudden symptoms, such as depressed mood; anxious, restless, or irritable behavior; panic attacks; or any unusual change in mood or behavior, occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur.

Quetiapine may rarely cause a prolonged, painful erection. This could happen even when you are not having sex. If this is not treated right away, it could lead to permanent sexual problems, such as impotence. Contact your doctor right away if this happens.

Quetiapine may raise your blood sugar. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away.

Diabetes patients - Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

NMS is a possibly fatal syndrome that can be caused by quetiapine. Symptoms may include fever; stiff muscles; confusion; abnormal thinking; fast or irregular heartbeat; and sweating. Contact your doctor at once if you have any of these symptoms.

Some patients who take quetiapine may develop muscle movements that they cannot control. This is more likely to happen in elderly patients, especially women. The chance that this will happen or that it will become permanent is greater in those who take quetiapine in higher doses or for a long time. Muscle problems may also occur after short-term treatment with low doses. Tell your doctor at once if you have muscle problems with your arms; legs; or your tongue, face, mouth, or jaw (eg, chewing movements, mouth puckering, puffing of cheeks, tongue sticking out) while taking quetiapine.

Rarely, quetiapine may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection, such as fever, sore throat, rash, or chills.

Quetiapine may increase the amount of a certain hormone (prolactin) in your blood. Symptoms may include enlarged breasts, missed menstrual period, decreased sexual ability, or nipple discharge. Contact your doctor right away if you experience any of these symptoms.

Tell your doctor or dentist that you take quetiapine before you receive any medical or dental care, emergency care, or surgery.

Quetiapine may interfere with certain lab tests, including certain urine drug screen tests. Be sure your doctor and lab personnel know you are taking quetiapine.

Lab tests, including complete blood cell counts, blood sugar or cholesterol levels, liver function, thyroid function, or eye exams, may be performed while you use quetiapine. You may also receive regular weight checks while you use quetiapine. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use quetiapine with caution in the ELDERLY; they may be more sensitive to its effects, especially uncontrolled muscle movements.

Increased blood pressure has been reported in CHILDREN and TEENAGERS who use quetiapine. Children and teenagers should receive regular blood pressure checks while they use quetiapine.

Quetiapine should be used with extreme caution in CHILDREN younger than 10 years old; safety and effectiveness in these children have not been confirmed.

PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking quetiapine while you are pregnant. Using quetiapine during the third trimester may result in uncontrolled muscle movements or withdrawal symptoms in the newborn. Discuss any questions or concerns with your doctor. Quetiapine is found in breast milk. Do not breast-feed while taking quetiapine.

If you stop taking quetiapine suddenly, you may have WITHDRAWAL symptoms. These may include diarrhea, dizziness, headache, irritability, nausea, trouble sleeping, or vomiting.

Possible side effects of quetiapine:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; dizziness; drowsiness; dry mouth; headache; increased appetite; indigestion; light-headedness; nausea; runny or stuffy nose; sluggishness; sore throat; stomach pain or upset; tiredness; vomiting; weakness; weight gain.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; difficult or painful urination; fainting; fast, slow, or irregular heartbeat; fever, chills, or persistent sore throat; hallucinations; increased saliva production or drooling; increased sweating; memory problems; menstrual changes; muscle pain, stiffness, or weakness; new or worsening mental or mood changes (eg, aggressiveness, agitation, anxiety, depression, exaggerated feeling of well-being, hostility, impulsiveness, inability to sit still, irritability, panic attacks, restlessness); numbness, burning, or tingling; persistent, painful erection; red, swollen, blistered, or peeling skin; seizures; severe or prolonged dizziness, light-headedness, or headache; severe stomach or back pain (with or without nausea or vomiting); shortness of breath; suicidal thoughts or actions; swelling of the arms, hands, legs, or feet; symptoms of high blood sugar (eg, increased thirst, hunger, or urination; unusual weakness); symptoms of high prolactin levels (eg, decreased sexual ability, enlarged breast size, missed menstrual period, nipple discharge); tremor; trouble concentrating, speaking, or swallowing; trouble sleeping; trouble walking or standing; uncontrollable or involuntary muscle movements (eg, loss of balance, twitching of the face or tongue, uncontrollable arm or leg movements); unusual bruising or bleeding; vision changes (eg, blurred vision, decreased vision).

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA .

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center. or emergency room immediately. Symptoms may include fainting; fast or irregular heartbeat; muscle pain, weakness, or cramping; seizures; severe dizziness, drowsiness, or light-headedness; uncontrolled muscle movements.

Proper storage of quetiapine:

Store quetiapine at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep quetiapine out of the reach of children and away from pets.

General information:

If you have any questions about quetiapine, please talk with your doctor, pharmacist, or other health care provider.

Quetiapine is to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take quetiapine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about quetiapine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to quetiapine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using quetiapine.

Review Date: August 8, 2016

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

More about quetiapine

Cool Offers From Divigel®, Divigel

Important Safety Information & Indication

Important Safety Information & Indication

Divigel ® (estradiol gel) 0.1% is indicated for the treatment of moderate to severe hot flashes due to menopause.

What is the most important information I should know about Divigel ® (an estrogen hormone)?

Using estrogen-alone increases your chance of getting cancer of the uterus (womb). Report any unusual vaginal bleeding right away while you are using Divigel ®. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Your healthcare provider should check any unusual bleeding to find out the cause.

Do not use estrogen-alone to prevent heart disease, heart attacks, strokes or dementia (decline of brain function)

Using estrogen-alone may increase your chances of getting strokes or blood clots

Using estrogen-alone may increase your chance of getting dementia, based on a study of women 65 years of age or older

Do not use estrogens with progestins to prevent heart disease, heart attacks, strokes or dementia

Using estrogens with progestins may increase your chances of getting heart attacks, strokes, breast cancer, or blood clots

Using estrogens with progestins may increase your chance of getting dementia, based on a study of women 65 years of age or older

You and your healthcare provider should talk regularly about whether you still need treatment with Divigel ®

Divigel ® should not be used if you have unusual vaginal bleeding, currently have or have had certain cancers, including cancer of the breast or uterus, had a stroke or heart attack; currently have or have had blood clots, currently have or have had liver problems, have been diagnosed with a bleeding disorder, are allergic to Divigel ® or any of its ingredients, or think you may be pregnant.

Tell your healthcare provider about all of your medical problems and the medicines you take, if you are going to have surgery or will be on bed rest, and if you are breastfeeding.

Call your healthcare provider right away if you get any of the following symptoms: new breast lumps, unusual vaginal bleeding, changes in vision or speech, sudden new severe headaches, or severe pains in your chest or legs with or without shortness of breath, weakness and fatigue.

Common side effects that may occur with Divigel ® include headache; breast pain; irregular vaginal bleeding or spotting; stomach or abdominal cramps, bloating; nausea and vomiting; hair loss; fluid retention and vaginal yeast infection.

Serious but less common side effects include heart attack, stroke, blood clots, dementia, breast cancer, cancer of the uterus, ovarian cancer, high blood pressure, high blood sugar, gallbladder disease, liver problems, and enlargement of benign uterus tumors (“fibroids”).

Alcohol-based gels are flammable. Avoid fire, flame or smoking until the gel has dried.

Please see Patient Information for Divigel ® and talk to your healthcare provider. For more information, call 732-721-0070 or visit www. divigel. com .

You are encouraged to report negative side effects to Vertical Pharmaceuticals, LLC at 1-877-95-VERTI (1-877-958-3784), or to the FDA by visiting www. fda. gov/medwatch or calling 1-800-FDA-1088.

Felodipine Oral Uses, Side Effects, Interactions, Pictures, Warnings - Dosing, Felodipinum

felodipine

Uses

OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.

This medication may also be used to prevent chest pain (angina ).

How to use felodipine

Take this medication by mouth usually once a day on an empty stomach. or as directed by your doctor. If stomach upset occurs, felodipine may be taken with a light meal. Dosage is based on your medical condition and response to therapy.

Do not crush or chew extended-release tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split the tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.

Use this medication regularly in order to get the most benefit from it. Remember to use it at the same time each day as directed. It is important to continue taking this medication even if you feel well. Most people with high blood pressure do not feel sick.

This drug is not effective if you use it only when chest pain occurs. It is very important to take this medication regularly as prescribed to help prevent chest pain.

Avoid eating grapefruit or drinking grapefruit juice while being treated with this medication unless your doctor instructs you otherwise. Grapefruit juice can increase the amount of this medication in your bloodstream. Consult your doctor or pharmacist for more details.

Do not stop taking this medication without consulting your doctor. Some conditions may become worse when the drug is suddenly stopped. Your dose may need to be gradually decreased.

Side Effects

Dizziness. lightheadedness, headache. flushing, or stomach upset may occur as your body adjusts to the medication. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if any of these serious side effects occur: swelling of the hands/ankles /feet (edema ).

Tell your doctor right away if any of these unlikely but serious side effects occur: fast/irregular heartbeat .

Although unlikely, felodipine may cause mild swelling of the gums. Massage your gums and brush and floss your teeth regularly to minimize this problem. See your dentist regularly.

Tell your doctor right away if this rare but very serious side effect occurs: fainting .

Although this medication is effective in preventing chest pain (angina), some people who already have severe heart disease may rarely develop worsening chest pain or a heart attack after starting this medication or increasing the dose. Get medical help right away if you experience: worsening chest pain, symptoms of a heart attack (such as chest/jaw/left arm pain, shortness of breath, unusual sweating ).

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction. including: rash. itching /swelling (especially of the face/tongue /throat), severe dizziness, trouble breathing .

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking felodipine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart disease (e. g. congestive heart failure ), liver disease, swelling of the arms and legs (edema).

Before having surgery, tell your doctor or dentist that you are taking this medication.

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

To minimize dizziness and lightheadedness, get up slowly when rising from a seated or lying position.

Caution is advised when using this drug in the elderly because they may be more sensitive to its side effects, especially dizziness.

This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.

It is not known whether this drug passes into breast milk. Consult your doctor before breast - feeding.

Interactions

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

See also How to Use section.

Before using this medication, it is important to tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: other medications for high blood pressure, intravenous (IV) calcium .

Also tell your doctor or pharmacist if you take drugs affecting the removal of felodipine from your system (CYP 3A4 substrates, inhibitors and inducers) such as: azole antifungals (e. g. itraconazole, ketoconazole), certain anti-seizure medications (e. g. carbamazepine. phenobarbital. phenytoin), cimetidine, macrolide antibiotics (e. g. erythromycin), tacrolimus.

Check the labels on all your medicines (such as cough-and-cold products, diet aids, or NSAIDs such as ibuprofen, naproxen) because they may contain ingredients that could increase your blood pressure. Ask your pharmacist for more details.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

Overdose

If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: severe dizziness, slow heartbeat, severe weakness.

Notes

Do not share this medication with others.

Lifestyle changes such as stress reduction programs, exercise, and dietary changes may increase the effectiveness of this medicine. Talk to your doctor or pharmacist about lifestyle changes that might benefit you.

Have your blood pressure checked regularly while taking this medication. It may be best to learn how to monitor your own blood pressure. Discuss with your doctor and inform him/her of your blood pressure readings.

Missed Dose

If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store the US product at room temperature below 86 degrees F (30 degrees C) away from light and moisture. Do not store in the bathroom.

Store the Canadian product at room temperature between 59 and 86 degrees F (15-30 degrees C) away from light and moisture. Do not store in the bathroom.

Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

MEDICAL ALERT: Your condition can cause complications in a medical emergency. For information about enrolling in MedicAlert, call 1-888-633-4298 (US) or 1-800-668-1507 (Canada).

Information last revised October 2015. Copyright(c) 2015 First Databank, Inc.

Images

Homemade Marshmallows Recipe Alton Brown Food Network, Amlow

Homemade Marshmallows

Ingredients

3 packages unflavored gelatin

1 cup ice cold water, divided

12 ounces granulated sugar, approximately 1 1/2 cups

1 cup light corn syrup

1/4 teaspoon kosher salt

1 teaspoon vanilla extract

1/4 cup confectioners' sugar

1/4 cup cornstarch

Nonstick spray

Directions

Place the gelatin into the bowl of a stand mixer along with 1/2 cup of the water. Have the whisk attachment standing by.

In a small saucepan combine the remaining 1/2 cup water, granulated sugar, corn syrup and salt. Place over medium high heat, cover and allow to cook for 3 to 4 minutes. Uncover, clip a candy thermometer onto the side of the pan and continue to cook until the mixture reaches 240 degrees F, approximately 7 to 8 minutes. Once the mixture reaches this temperature, immediately remove from the heat.

Turn the mixer on low speed and, while running, slowly pour the sugar syrup down the side of the bowl into the gelatin mixture. Once you have added all of the syrup, increase the speed to high. Continue to whip until the mixture becomes very thick and is lukewarm, approximately 12 to 15 minutes. Add the vanilla during the last minute of whipping. While the mixture is whipping prepare the pans as follows.

For regular marshmallows:

Combine the confectioners' sugar and cornstarch in a small bowl. Lightly spray a 13 by 9-inch metal baking pan with nonstick cooking spray. Add the sugar and cornstarch mixture and move around to completely coat the bottom and sides of the pan. Return the remaining mixture to the bowl for later use.

When ready, pour the mixture into the prepared pan, using a lightly oiled spatula for spreading evenly into the pan. Dust the top with enough of the remaining sugar and cornstarch mixture to lightly cover. Reserve the rest for later. Allow the marshmallows to sit uncovered for at least 4 hours and up to overnight.

Turn the marshmallows out onto a cutting board and cut into 1-inch squares using a pizza wheel dusted with the confectioners' sugar mixture. Once cut, lightly dust all sides of each marshmallow with the remaining mixture, using additional if necessary. Store in an airtight container for up to 3 weeks.

For miniature marshmallows:

Combine the confectioners' sugar and cornstarch in a small bowl. Line 4 half sheet pans with parchment paper, spray the paper with nonstick cooking spray and dust with the confectioners' sugar mixture.

Scoop the mixture into a piping bag fitted with a 1/2-inch round piping tip. Pipe the mixture onto the prepared sheet pans lengthwise, leaving about 1-inch between each strip. Sprinkle the tops with enough of the remaining cornstarch and sugar mixture to lightly cover. Let the strips set for 4 hours or up to overnight.

Cut into 1/2 inch pieces using a pizza wheel or scissors dusted with the confectioners' sugar mixture. Once cut, lightly dust all sides of each marshmallow with the remaining sugar mixture and store in an airtight container for up to a week.

Recipe courtesy of Alton Brown, 2007

What Is Lox Jewish Recipes, Lox

Lox is salmon, typically a filet, that has been cured, and then often it is cold smoked. The cold smoking does not cook the fish, resulting in its characteristic smooth texture similar to the raw product.

Variations on the name are lox (Yiddish), lax (Swedish), laks (Norwegian and Danish) and lachs (German). Also See: Lox Recipes

It is often served with cream cheese and / or on bagels .

Regular: Brined in a solution of water, salt, sometimes sugars and spices (the brine). This is called "wet brining". Then the fish may be cold smoked.

Nova or Nova Scotia lox: Similar to regular lox, but cured with a milder brine. The fish is then cold smoked. The name dates from a time when much of the salmon in New York came from Nova Scotia. Today, however, the name refers to the milder brining, as compared to regular lox, and the fish may come from other ocean areas than Nova Scotia, or even be raised on farms.

Scottish lox: A mixture of salt and sometimes sugars, spices and other flavorings are applied directly to the meat of the fish for a period of time. This is called "dry brining" or "Scottish style". The brine mixture is then rinsed off, and the fish is cold smoked.

Scandinavian lox: The fish is salt cured and cold smoked. Gravad lox: Also known as Gravad lax or Gravlax, this is a traditional Scandinavian means of preparing lox (salmon). Gravad lox is not smoked, but it can be served in a similar fashion. The salmon is coated with a spice mixture, which often includes dill, sugars, and spices like juniper berry. It is then weighted down to force the moisture from the fish and impart the flavorings. It is often served with a sweet mustard-dill sauce.

Amobay® Suspension, Amobay

Amobay® Suspension

AMOBAY® SUSPENSION: Cada 5 ml de SUSPENSION contienen: Amoxicilina trihidratada equivalente a 250 mg 500 mg de amoxicilina, Vehiculo, c. b.p. 5 ml 5 ml INDICACIONES TERAPEUTICAS: AMOBAY®, amoxicilina trihidratada, esta indicada para el tratamiento de infecciones causadas por microorganismos susceptibles en las vias respiratorias altas y bajas (rinosinusitis bacteriana aguda, otitis media aguda, faringitis, faringoamigdalitis, bronquitis bacteriana, neumonia); del tracto gastrointestinal (gastroenteritis bacteriana, fiebre tifoidea) y del tracto genitourinario (IVU no complicadas, pielonefritis, infecciones por Chlamydia en mujeres embarazadas, quienes no pueden tolerar la eritromicina; infecciones uretrales y anogenitales agudas no complicadas debidas a Neisseria gonorrhoeae); de la piel y tejidos blandos; estructuras dentales y adyacentes en la cavidad oral. Tambien esta indicado para el tratamiento de la borreliosis o enfermedad de Lyme (primer estadio de la infeccion temprana o infeccion localizada) y en la infeccion diseminada (2A° estadio). Amoxicilina, en asociacion con un inhibidor de la bomba de protones (lanzoprazol) y claritromicina, esta indicada como terapia triple para el tratamiento de ulcera peptica (duodenal) causada por H. pylori durante un regimen de 14 dias. Amoxicilina en combinacion con capsulas de liberacion modificada de lanzoprazol, esta indicada como terapia dual para el tratamiento de pacientes con infeccion por H. pylori y ulcera duodenal, quienes son alergicos o intolerantes a la claritromicina, o en quienes la resistencia a la claritromicina es conocida o sospechada. Tambien esta indicado como preventivo de endocarditis infecciosa posterior a procesos invasivos de diagnostico o de tratamiento quirurgicos en vias respiratorias, digestivas y en extraccion dental. Los procedimientos quirurgicos o de diagnostico sugeridos que requieren profilaxis son: extraccion dental, amigdalectomia, adenoidectomia, broncoscopia rigida incluyendo lavado o biopsia, escleroterapia de varices esofagicas y dilatacion del esofago.

AMOBAY® esta contraindicada en pacientes con hipersensibilidad conocida a las penicilinas o cualquier otro componente de la formula. La incidencia de hipersensibilidad cruzada entre penicilinas y otros antibioticos A?-lactamicos como cefalosporinas y carbapenems no es conocida precisamente, aunque algunos autores consideran es de 3 a 5%. Estas reacciones se han observado frecuentemente en pacientes con historia de hipersensibilidad a multiples alergenos, asma o fiebre del heno. Todos los pacientes deben ser cuidadosamente interrogados sobre historia de hipersensibilidad a las penicilinas y/o otros antibioticos A?-lactamicos o alergenos, la presencia del sindrome de Stevens-Johnson, eritrodermia o dermatitis exfoliativa independientemente de la intensidad de las reacciones antes de prescribir AMOBAY®. Reacciones de hipersensibilidad graves con resultados fatales despues de la administracion de penicilinas se han reportado raramente. Aunque la anafilaxia es generalmente menos frecuente (0.2% en 1,000 casos del tratamiento) y es mas comun cuando se usa la terapia parenteral, se han documentado reportes cuando se usa el tratamiento oral con penicilinas. Es preferible no indicar AMOBAY® si no se realizo un programa previo de desensibilizacion. Siempre que ocurra hipersensibilidad grave o reaccion alergica, la terapia con amoxicilina debe ser descontinuada e iniciar el tratamiento apropiado. Reacciones anafilacticas serias (respiracion rapida o irregular, brevedad de la respiracion [taquipnea], inflamacion o edema facial; disminucion de la presion sanguinea repentina y grave) requiere tratamiento inmediato de emergencia con adrenalina, oxigeno, esteroides intravenosos y manejo de las vias respiratorias, requiriendo a veces intubacion orotraqueal. Debido a que pacientes con leucemia linfocitica y mononucleosis infecciosa tiene rango creciente para desarrollar erupcion maculopapular (rash), AMOBAY® debe ser usado con precaucion o evitarlo si es posible. Lo mismo ocurre en los pacientes con infeccion por el VIH/SIDA, otras infecciones virales y especialmente en los pacientes con mononucleosis. La eliminacion de AMOBAY® puede retrasarse debido a la funcion renal inmadura en neonatos y ninos, por lo que, la dosificacion debe ser ajustada en pacientes pediatricos de 12 semanas o menores. Las penicilinas se han usado en pacientes geriatricos y ningun problema especifico en esta poblacion se ha documentado a la fecha. Sin embargo, los pacientes adultos mayores son mas propensos a tener alteraciones renales en funcion de la edad que pueden requerir un ajuste en la dosificacion, incluyendo AMOBAY®. El uso prolongado de penicilinas, incluyendo AMOBAY®, puede conducir al desarrollo de candidiasis vaginal y/u oral. RESTRICCIONES DE USO DURANTE EL EMBARAZO Y LA LACTANCIA: Las penicilinas son habitualmente usadas en mujeres embarazadas y no se han reportado eventos adversos. AMOBAY® se clasifica como categoria B de acuerdo a lo establecido en el sistema de calificacion del uso de medicamentos en el embarazo de la Administracion de Farmacos y Alimentos (FDA) de los EUA. Esto significa, que los estudios en animales no han demostrado riesgo alguno en el feto, pero no se han realizado estudios controlados en humanos; o los estudios en animales aunque han demostrado riesgo, en los humanos no se ha demostrado riesgo alguno. AMOBAY® atraviesa la placenta y alcanza concentraciones en suero del feto de 25-33% de la concentracion plasmatica materna. Durante la lactancia se pueden detectar bajas concentraciones de amoxicilina en la leche materna. Mujeres lactando bajo tratamiento con amoxicilina pueden provocar la sensibilizacion, erupcion en la piel (rash), diarrea o candidiasis en infantes. El riesgo debe ser considerado cuando se trate a un infante cuya madre lactante este bajo tratamiento con amoxicilina. Oriente a la madre sobre la baja posibilidad de cualquier reaccion de hipersensibilidad que el infante pueda presentar, cuando las penicilinas le sean administradas en el futuro. REACCIONES SECUNDARIAS Y ADVERSAS: Como con otros antibioticos, las reacciones adversas mas comunes estan relacionadas al tracto digestivo. Nauseas, vomito, anorexia, diarrea, dolor epigastrico, gastritis y dolor abdominal son las reacciones adversas mas comunes reportadas en el tracto gastrointestinal. Tambien se han observado lengua negra, glositis y estomatitis. La asociacion de antibioticos a la colitis seudomembranosa secundaria a Clostridium difficile puede aparecer durante o despues del tratamiento con AMOBAY® aunque esta reaccion adversa es muy rara. Tambien se han reportado dolor abdominal severo y diarrea con sangre asociada con enterocolitis aguda transitoria, pero sin evidencia de colitis seudomembranosa. Casos leves de colitis seudomembranosa usualmente responden al tratamiento de descontinuacion. Casos moderados a graves pueden requerir liquidos y electrolitos, suplementos proteinicos y cualquier antibacteriano recomendado para el tratamiento de colitis por C. difficile. En raras ocasiones se ha observado nefritis intersticial con necrosis tubular renal y sindrome nefrotico. Los efectos secundarios mas frecuentes son los asociados a reacciones de hipersensibilidad y pueden variar desde rash eritematoso morbiliforme leve hasta reacciones anafilacticas serias (vease abajo). Se ha descrito eritema multiforme, dermatitis exfoliativa, rash maculopapular con eritema (no mediada inmunologicamente), necrolisis epidermica toxica, sindrome de Stevens-Johnson, vasculitis, urticaria y reacciones de la enfermedad del suero. La incidencia total de rash en pacientes tomando amoxicilina es de 1.4 a 10%, siendo mayor a 65% las de tipo maculopapular. Los efectos adversos sobre el sistema nervioso central incluyen cefalea, agitacion psicomotriz, insomnio y confusion, aunque no son muy frecuentes. Se han descrito convulsiones en pacientes con insuficiencia renal a los que se administraron penicilinas a dosis altas, por lo que es recomendable ajustar las dosis y, por consiguiente, cuando se sabe o se sospecha de dano renal. Se han reportado durante la terapia con amoxicilina: eosinofilia y hemolisis, anemia (incluyendo anemia hemolitica), trombocitopenia, purpura trombocitopenica, neutropenia, leucopenia y agranulocitosis. Estas reacciones adversas son generalmente reversibles al descontinuar el tratamiento. En el higado se han reportado disfuncion hepatica incluyendo ictericia colestatica, colestasis hepatica y hepatitis citolitica severa. INTERACCIONES MEDICAMENTOSAS Y DE OTRO GENERO: La administracion concomitante de amilorida y amoxicilina reduce la biodisponibilidad del antibiotico en 27% y la Cmax. en 25%. No se observaron variaciones en la depuracion renal de la amoxicilina. Aunque se desconoce la significancia clinica de esta interaccion, se recomienda no administrar ambos farmacos simultaneamente dejando transcurrir unas dos horas como minimo entre uno y otro farmaco. El probenecid inhibe la excrecion tubular de muchos farmacos incluyendo la amoxicilina y aumentando los niveles plasmaticos del antibiotico. Aunque con esta interaccion se espera se aumenten las concentraciones del antibiotico en suero, no se han reportado problemas con esta interaccion, el uso de probenecid se debe evitar en pacientes con dano renal grave. Los aminoglucosidos se utilizan actualmente junto con amoxicilina debido a efecto sinergico contra enterococos y estreptococos del grupo B. Sin embargo, por existir incompatibilidad quimica, ambos antibioticos no se deben mezclar ni administrar al mismo tiempo. Algunas penicilinas inactivan los antibioticos aminoglucosidos cuando se mezclan en la misma infusion intravenosa. Pueden interferir con los efectos bacterianos de penicilina: cloranfenicol, macrolidos, sulfonamidas y tetraciclinas. Esto ha sido demostrado in vitro; sin embargo, la importancia clinica de esta interaccion no esta bien documentada. La neomicina inhibe parcialmente la absorcion de amoxicilina. La amoxicilina, a dosis altas, puede reducir la eficacia de los anticonceptivos orales que contienen estrogenos. Se han documentado casos de fracasos anticonceptivos en pacientes tratadas con amoxicilina, aunque se desconoce la naturaleza de esta interaccion. Por lo tanto, se recomienda advertir a las pacientes que se encuentren bajo tratamiento con anticonceptivos orales de la posibilidad de un fallo anticonceptivo durante el tratamiento con amoxicilina para que tomen medidas pertinentes. El nifedipino parece aumentar la absorcion de la amoxicilina estimulando el transporte activo del antibiotico a traves del epitelio intestinal. Sin embargo, esta interaccion factiblemente no tiene ninguna significancia clinica. La bromelina aumenta la absorcion de la amoxicilina. Se observo que 80 mg de bromelina administrada conjuntamente con la amoxicilina aumentaba los niveles plasmaticos del antibiotico, aunque se desconoce el mecanismo de interaccion. Se ha documentado que la bromelina mejora la accion antibacteriana de algunos antibioticos como la penicilina, el cloramfenicol y la eritromicina en el tratamiento de infecciones recurrentes y en pacientes que no habian respondido previamente a un tratamiento. Se observo que los pacientes respondieron al tratamiento al anadir bromelina 4 veces al dia. En algunos casos se prescriben dosis de bromelina de 2,400 u. d.g. (unidades disolventes de gelatina). ALTERACIONES EN LOS RESULTADOS DE PRUEBAS DE LABORATORIO: Se han observado falsos positivos en las determinaciones de glucosuria en pacientes tratados con penicilinas, en las pruebas que usan solucion de Benedict o de Fehling o Clinitest®. Sin embargo, esta interaccion no se produce con las tiras reactivas basadas en la glucosa-oxidasa. Se ha observado aumento transitorio y moderado en suero de la aspartato aminotransferasa (AST), fosfatasa alcalina y deshidrogenasa lactica, pero la importancia clinica de estas conclusiones es desconocida. Se ha observado con la administracion siguiente de ampicilina a mujeres embarazadas: disminucion transitoria en las concentraciones de plasma de estriol conjugado total, estriol-glucuronido, estrona conjugada y estradiol. Este efecto puede tambien ocurrir con amoxicilina.

Restricciones de uso durante el embarazo y la lactancia:

Las penicilinas son habitualmente usadas en mujeres embarazadas y no se han reportado eventos adversos. AMOBAY® se clasifica como categoria B de acuerdo a lo establecido en el sistema de calificacion del uso de medicamentos en el embarazo de la Administracion de Farmacos y Alimentos (FDA) de los EUA. Esto significa, que los estudios en animales no han demostrado riesgo alguno en el feto, pero no se han realizado estudios controlados en humanos; o los estudios en animales aunque han demostrado riesgo, en los humanos no se ha demostrado riesgo alguno. AMOBAY® atraviesa la placenta y alcanza concentraciones en suero del feto de 25-33% de la concentracion plasmatica materna. Durante la lactancia se pueden detectar bajas concentraciones de amoxicilina en la leche materna. Mujeres lactando bajo tratamiento con amoxicilina pueden provocar la sensibilizacion, erupcion en la piel (rash), diarrea o candidiasis en infantes. El riesgo debe ser considerado cuando se trate a un infante cuya madre lactante este bajo tratamiento con amoxicilina. Oriente a la madre sobre la baja posibilidad de cualquier reaccion de hipersensibilidad que el infante pueda presentar, cuando las penicilinas le sean administradas en el futuro.

Reacciones secundarias o adversas:

Como con otros antibioticos, las reacciones adversas mas comunes estan relacionadas al tracto digestivo. Nauseas, vomito, anorexia, diarrea, dolor epigastrico, gastritis y dolor abdominal son las reacciones adversas mas comunes reportadas en el tracto gastrointestinal. Tambien se han observado lengua negra, glositis y estomatitis. La asociacion de antibioticos a la colitis seudomembranosa secundaria a Clostridium difficile puede aparecer durante o despues del tratamiento con AMOBAY® aunque esta reaccion adversa es muy rara. Tambien se han reportado dolor abdominal severo y diarrea con sangre asociada con enterocolitis aguda transitoria, pero sin evidencia de colitis seudomembranosa. Casos leves de colitis seudomembranosa usualmente responden al tratamiento de descontinuacion. Casos moderados a graves pueden requerir liquidos y electrolitos, suplementos proteinicos y cualquier antibacteriano recomendado para el tratamiento de colitis por C. difficile. En raras ocasiones se ha observado nefritis intersticial con necrosis tubular renal y sindrome nefrotico. Los efectos secundarios mas frecuentes son los asociados a reacciones de hipersensibilidad y pueden variar desde rash eritematoso morbiliforme leve hasta reacciones anafilacticas serias (vease abajo). Se ha descrito eritema multiforme, dermatitis exfoliativa, rash maculopapular con eritema (no mediada inmunologicamente), necrolisis epidermica toxica, sindrome de Stevens-Johnson, vasculitis, urticaria y reacciones de la enfermedad del suero. La incidencia total de rash en pacientes tomando amoxicilina es de 1.4 a 10%, siendo mayor a 65% las de tipo maculopapular. Los efectos adversos sobre el sistema nervioso central incluyen cefalea, agitacion psicomotriz, insomnio y confusion, aunque no son muy frecuentes. Se han descrito convulsiones en pacientes con insuficiencia renal a los que se administraron penicilinas a dosis altas, por lo que es recomendable ajustar las dosis y, por consiguiente, cuando se sabe o se sospecha de dano renal. Se han reportado durante la terapia con amoxicilina: eosinofilia y hemolisis, anemia (incluyendo anemia hemolitica), trombocitopenia, purpura trombocitopenica, neutropenia, leucopenia y agranulocitosis. Estas reacciones adversas son generalmente reversibles al descontinuar el tratamiento. En el higado se han reportado disfuncion hepatica incluyendo ictericia colestatica, colestasis hepatica y hepatitis citolitica severa.

Interacciones Medicamentosas Y De Otro Genero:

La administracion concomitante de amilorida y amoxicilina reduce la biodisponibilidad del antibiotico en 27% y la Cmax. en 25%. No se observaron variaciones en la depuracion renal de la amoxicilina. Aunque se desconoce la significancia clinica de esta interaccion, se recomienda no administrar ambos farmacos simultaneamente dejando transcurrir unas dos horas como minimo entre uno y otro farmaco. El probenecid inhibe la excrecion tubular de muchos farmacos incluyendo la amoxicilina y aumentando los niveles plasmaticos del antibiotico. Aunque con esta interaccion se espera se aumenten las concentraciones del antibiotico en suero, no se han reportado problemas con esta interaccion, el uso de probenecid se debe evitar en pacientes con dano renal grave. Los aminoglucosidos se utilizan actualmente junto con amoxicilina debido a efecto sinergico contra enterococos y estreptococos del grupo B. Sin embargo, por existir incompatibilidad quimica, ambos antibioticos no se deben mezclar ni administrar al mismo tiempo. Algunas penicilinas inactivan los antibioticos aminoglucosidos cuando se mezclan en la misma infusion intravenosa. Pueden interferir con los efectos bacterianos de penicilina: cloranfenicol, macrolidos, sulfonamidas y tetraciclinas. Esto ha sido demostrado in vitro; sin embargo, la importancia clinica de esta interaccion no esta bien documentada. La neomicina inhibe parcialmente la absorcion de amoxicilina. La amoxicilina, a dosis altas, puede reducir la eficacia de los anticonceptivos orales que contienen estrogenos. Se han documentado casos de fracasos anticonceptivos en pacientes tratadas con amoxicilina, aunque se desconoce la naturaleza de esta interaccion. Por lo tanto, se recomienda advertir a las pacientes que se encuentren bajo tratamiento con anticonceptivos orales de la posibilidad de un fallo anticonceptivo durante el tratamiento con amoxicilina para que tomen medidas pertinentes. El nifedipino parece aumentar la absorcion de la amoxicilina estimulando el transporte activo del antibiotico a traves del epitelio intestinal. Sin embargo, esta interaccion factiblemente no tiene ninguna significancia clinica. La bromelina aumenta la absorcion de la amoxicilina. Se observo que 80 mg de bromelina administrada conjuntamente con la amoxicilina aumentaba los niveles plasmaticos del antibiotico, aunque se desconoce el mecanismo de interaccion. Se ha documentado que la bromelina mejora la accion antibacteriana de algunos antibioticos como la penicilina, el cloramfenicol y la eritromicina en el tratamiento de infecciones recurrentes y en pacientes que no habian respondido previamente a un tratamiento. Se observo que los pacientes respondieron al tratamiento al anadir bromelina 4 veces al dia. En algunos casos se prescriben dosis de bromelina de 2,400 u. d.g. (unidades disolventes de gelatina).

Alteraciones en los resultados de pruebas de laboratorio:

Se han observado falsos positivos en las determinaciones de glucosuria en pacientes tratados con penicilinas, en las pruebas que usan solucion de Benedict o de Fehling o Clinitest®. Sin embargo, esta interaccion no se produce con las tiras reactivas basadas en la glucosa-oxidasa. Se ha observado aumento transitorio y moderado en suero de la aspartato aminotransferasa (AST), fosfatasa alcalina y deshidrogenasa lactica, pero la importancia clinica de estas conclusiones es desconocida. Se ha observado con la administracion siguiente de ampicilina a mujeres embarazadas: disminucion transitoria en las concentraciones de plasma de estriol conjugado total, estriol-glucuronido, estrona conjugada y estradiol. Este efecto puede tambien ocurrir con amoxicilina.

Precauciones en relacion con efectos de carcinogenesis, mutagenesis, teratogenesis y sobre la fertilidad:

No se han realizado estudios a largo plazo en animales para evaluar el potencial carcinogenico. Estudios para detectar potencial mutagenico de la amoxicilina sola no se han llevado acabo. Todas las penicilinas atraviesan la placenta. No se han hecho estudios bien controlados en humanos para determinar si las penicilinas son teratogenicas. Estudios en ratones y ratas hasta 10 veces la dosis humana de amoxicilina, no revelan evidencia de dano al feto. Debido a que los estudios de reproduccion animal no son siempre predictivos de la respuesta humana, AMOBAY® debe ser usado en el embarazo solo si su requerimiento esta bien fundamentado.

Dosis y via de administracion:

AMOBAY® Capsulas son administradas por via oral con el estomago lleno o vacio y pueden ser administradas con formulas lacteas, leche, jugos de frutas, vegetales u otras bebidas (240 ml). La dosis actual para adultos o ninos de > 40 kg de peso corporal es de 250-500 mg/kg cada 8 horas de acuerdo a la gravedad de la infeccion. Ninos de 80 80-30 30-10

Trazodone, Desyrel Drug Facts, Side Effects And Dosing, Mesyrel

trazodone, Desyrel (discontinued brand)

Omudhome Ogbru, PharmD

Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

Jay W. Marks, MD

Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

Charles Patrick Davis, MD, PhD

Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

Quick Guide Depression Hurts: Physical Symptoms of Depression

Naproxen Oral Uses, Side Effects, Interactions, Pictures, Warnings - Dosing, Neoprox

naproxen

GENERIC NAME(S): NAPROXEN

Warnings

Nonsteroidal anti-inflammatory drugs (including naproxen ) may rarely increase the risk for a heart attack or stroke. The risk may be greater if you have heart disease or increased risk for heart disease (for example, due to smoking. family history of heart disease. or conditions such as high blood pressure or diabetes ), or with longer use. This drug should not be taken right before or after heart bypass surgery (CABG).

This drug may rarely cause serious (rarely fatal) bleeding from the stomach or intestines. This effect can occur without warning at any time while taking this drug. Older adults may be at higher risk for this effect.

Stop taking naproxen and get medical help right away if you notice any of these rare but serious side effects: black/tarry stools, persistent stomach /abdominal pain. vomit that looks like coffee grounds, chest/jaw/left arm pain, shortness of breath, unusual sweating. confusion, weakness on one side of the body, slurred speech, sudden vision changes.

Talk to your doctor or pharmacist about the benefits and risks of taking this drug.

Uses

Naproxen is used to relieve pain from various conditions such as headaches. muscle aches, tendonitis. dental pain, and menstrual cramps. It also reduces pain, swelling, and joint stiffness caused by arthritis. bursitis. and gout attacks. This medication is known as a nonsteroidal anti-inflammatory drug (NSAID). It works by blocking your body's production of certain natural substances that cause inflammation .

If you are treating a chronic condition such as arthritis. ask your doctor about non-drug treatments and/or using other medications to treat your pain. See also Warning section.

How to use naproxen

Read the Medication Guide provided by your pharmacist before you start using naproxen and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth as directed by your doctor, usually 2 or 3 times a day with a full glass of water (8 ounces/240 milliliters). Do not lie down for at least 10 minutes after taking this drug. To prevent stomach upset, take this medication with food, milk, or an antacid.

The dosage is based on your medical condition and response to treatment. To reduce your risk of stomach bleeding and other side effects, take this medication at the lowest effective dose for the shortest possible time. Do not increase your dose or take this drug more often than directed. For ongoing conditions such as arthritis, continue taking this medication as directed by your doctor.

For certain conditions (such as arthritis), it may take up to two weeks of taking this drug regularly until you get the full benefit.

If you are taking this drug "as needed" (not on a regular schedule), remember that pain medications work best if they are used as the first signs of pain occur. If you wait until the pain has worsened, the medication may not work as well.

Tell your doctor if your condition does not improve or if it worsens.

Side Effects

See also Warning section.

Upset stomach. nausea. heartburn. headache. drowsiness, or dizziness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

This medication may raise your blood pressure. Check your blood pressure regularly and tell your doctor if the results are high.

Tell your doctor right away if you have any serious side effects, including: easy bruising/bleeding, difficult/painful swallowing, hearing changes (such as ringing in the ears ), mental/mood changes, swelling of the ankles /feet/hands, sudden/unexplained weight gain. signs of kidney problems (such as change in the amount of urine), unexplained stiff neck. vision changes, unusual tiredness.

This drug may rarely cause serious (possibly fatal) liver disease. Get medical help right away if you have any symptoms of liver damage, including: dark urine, persistent nausea/vomiting/loss of appetite, stomach/abdominal pain, yellowing eyes /skin .

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction. including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing .

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking naproxen, tell your doctor or pharmacist if you are allergic to it; or to aspirin or other NSAIDs (such as ibuprofen, celecoxib); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before taking this medication, tell your doctor or pharmacist your medical history, especially of: asthma (including a history of worsening breathing after taking aspirin or other NSAIDs), blood disorders (such as anemia, bleeding/clotting problems), growths in the nose (nasal polyps), heart disease (such as previous heart attack), high blood pressure, liver disease, stroke, throat/stomach/intestinal problems (such as bleeding, heartburn, ulcers).

Kidney problems can sometimes occur with the use of NSAID medications, including naproxen. Problems are more likely to occur if you are dehydrated, have heart failure or kidney disease, are an older adult, or if you take certain medications (see also Drug Interactions section). Drink plenty of fluids as directed by your doctor to prevent dehydration and tell your doctor right away if you have any unusual change in the amount of urine.

This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely.

This medicine may cause stomach bleeding. Daily use of alcohol and tobacco, especially when combined with this medicine, may increase your risk for stomach bleeding. Limit alcohol and stop smoking. Consult your doctor or pharmacist for more information.

This medication may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen and wear protective clothing when outdoors.

Some naproxen products contain salt (sodium). Tell your doctor if you are on a salt-restricted diet.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Older adults may be more sensitive to the side effects of this drug, especially stomach/intestinal bleeding and kidney problems.

Before using this medication, women of childbearing age should talk with their doctor(s) about the benefits and risks (such as miscarriage, trouble getting pregnant). Tell your doctor if you are pregnant or if you plan to become pregnant. During pregnancy, this medication should be used only when clearly needed. It is not recommended for use during the first and last trimesters of pregnancy due to possible harm to the unborn baby and interference with normal labor/delivery.

This drug passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Products that may interact with this drug include: aliskiren, ACE inhibitors (such as captopril, lisinopril), angiotensin II receptor blockers (such as losartan, valsartan), cidofovir, corticosteroids (such as prednisone), lithium, "water pills" (diuretics such as furosemide).

This medication may increase the risk of bleeding when taken with other drugs that also may cause bleeding. Examples include anti-platelet drugs such as clopidogrel, "blood thinners" such as dabigatran/enoxaparin/warfarin, among others.

Check all prescription and nonprescription medicine labels carefully since many medications contain pain relievers/fever reducers (aspirin, NSAIDs such as celecoxib, ibuprofen, or ketorolac). These drugs are similar to naproxen and may increase your risk of side effects if taken together. However, if your doctor has directed you to take low-dose aspirin to prevent heart attack or stroke (usually at dosages of 81-325 milligrams a day), you should continue taking the aspirin unless your doctor instructs you otherwise. Daily use of naproxen may decrease aspirin's ability to prevent heart attack/stroke. Talk to your doctor about using a different medication (such as acetaminophen) to treat pain/fever. If you must take naproxen, talk to your doctor about possibly taking immediate-release aspirin (not enteric-coated/EC) and then taking your naproxen at a different time after your aspirin. Do not increase your daily dose of aspirin or change the way you take aspirin/other medications without your doctor's approval.

This medication can affect the results of certain laboratory tests, possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

Overdose

If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: severe stomach pain, extreme drowsiness, seizures.

Notes

Do not share this medication with others.

Laboratory and/or medical tests (such as blood pressure, complete blood count, liver/kidney function) may be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

If you have arthritis, lifestyle changes (such as weight loss if needed, strengthening/conditioning exercises) may help improve your flexibility and joint function. Consult your doctor for specific instructions.

Missed Dose

If you are taking this drug on a regular schedule (not just "as needed") and you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Information last revised May 2016. Copyright(c) 2016 First Databank, Inc.

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Anacin - Pain Relief, Minafen

Anacin is a pain reliever intended for the temporary relief of minor aches and pains. Anacin is a combination salicylate and stimulant. It works by blocking several different chemical processes within the body that cause pain, inflammation, and fever. It also reduces the tendency for blood to clot.

Availability: In Stock (17 packs)

Anacin is used for treating pain including, headache, muscle aches, sprains, tooth extraction and toothache, menstrual cramps, arthritis and rheumatism, and pain and fever of the common cold. It may also be used for other conditions as determined by your doctor.

Use Anacin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take Anacin by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation. Taking it with food may not decrease the risk of stomach or bowel problems (eg, bleeding, ulcers) that may occur while taking Anacin.

Take Anacin with a full glass of water (8 oz/240 mL). Do not lie down for 30 minutes after taking Anacin.

Use Anacin exactly as directed on the package, unless instructed differently by your doctor. If you are taking Anacin without a prescription, follow any warnings and precautions on the label.

If you miss a dose of Anacin and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Anacin.

Store Anacin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Anacin out of the reach of children and away from pets.

Anacin may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Anacin with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

Avoid large amounts of food or drink that have caffeine (eg, coffee, tea, cocoa, cola, chocolate). This includes any medicines that contain caffeine.

Anacin has aspirin in it. Before you start any new medicine, check the label to see if it has aspirin in it too. If it does or if you are not sure, check with your doctor or pharmacist.

Talk to your doctor before you take Anacin or other pain relievers/fever reducers if you drink more than 3 drinks with alcohol per day. Serious stomach ulcers or bleeding can occur with the use of Anacin. Taking it in high doses or for a long time, smoking, or drinking alcohol increases the risk of these side effects. Taking Anacin with food will NOT reduce the risk of these effects. Contact your doctor or emergency room at once if you develop severe stomach or back pain; black, tarry stools; vomit that looks like blood or coffee grounds; or unusual weight gain or swelling.

Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor. Taking more than the recommended dose or taking Anacin regularly may be habit-forming.

Anacin may reduce the number of clot-forming cells (platelets) in your blood. To prevent bleeding, avoid situations in which bruising or injury may occur. Report any unusual bleeding, bruising, blood in stools, or dark, tarry stools to your doctor.

Aspirin has been linked to a serious illness called Reye syndrome. Do not give Anacin to a child or teenager who has the flu, chickenpox, or a viral infection. Contact your doctor with any questions or concerns.

Diabetes patients - Anacin may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

If Anacin has a strong vinegar-like smell upon opening, do not use. It means the medicine is breaking down. Throw the bottle away safely and out of the reach of children; contact your pharmacist and replace.

Tell your doctor or dentist that you take Anacin before you receive any medical or dental care, emergency care, or surgery.

Do not take Anacin for at least 7 days after any surgery unless directed by your health care provider.

Do not take Anacin for more than 10 days for pain or for more than 3 days for fever unless directed to do so by your health care provider.

Different brands of Anacin may have different dosing instructions for CHILDREN. Follow the dosing instructions on the package labeling. If your doctor has given you instructions, follow those. If you are unsure of the dose to give a child, check with your doctor or pharmacist.

Do NOT use Anacin if:

you are allergic to any ingredient in Anacin

you are a child or teenager with influenza (flu) or chickenpox

you have bleeding problems such as hemophilia, von Willebrand disease, or low blood platelets, or you have active severe bleeding

you have had a severe allergic reaction (eg, severe rash, hives, breathing difficulties, dizziness) to aspirin, tartrazine, or a nonsteroidal anti-inflammatory drug (NSAID) (eg, ibuprofen, naproxen, celecoxib)

you are taking anticoagulants (eg, heparin, warfarin) or methotrexate

Before using Anacin:

Some medical conditions may interact with Anacin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have alcoholism or if you consume 3 or more alcohol-containing drinks every day

if you have asthma, bleeding or clotting problems, growths in the nose (nasal polyps), kidney or liver problems, stomach or intestinal problems (eg, ulcer, inflammation), heart problems, heartburn, upset stomach, stomach pain, hives, influenza (flu) or chickenpox, or vitamin K deficiency

if you have anxiety, trouble sleeping, or heart problems

if you are a child with a stroke, a weakened blood vessel (cerebral aneurysm) or bleeding in the brain, rheumatic disease (eg, rheumatoid arthritis), or Kawasaki syndrome (a rare inflammation causing heart problems in children)

Some MEDICINES MAY INTERACT with Anacin. Tell your health care provider if you are taking any other medicines.

PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Anacin while you are pregnant. Anacin is not recommended during the last 3 months (third trimester) of pregnancy because it may cause harm to the fetus. Anacin is found in breast milk. If you are or will be breast-feeding while you use Anacin, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects. Anacin's side effects may include dizziness, heartburn, irritability, nausea, nervousness, rashes, hives, bloody stools, drowsiness, hearing loss, ringing in the ears, and trouble sleeping.

Check with your doctor if any of the listed above most COMMON side effects persist or become bothersome.

Seek medical attention right away if any of these SEVERE side effects occur: severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black or bloody stools; confusion; diarrhea; drowsiness; hearing loss; ringing in the ears; severe or persistent dizziness; severe or persistent stomach pain or heartburn; shakiness; trouble sleeping; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects.

Sanaflu Xtra Trademark Of Grandall Distributing Co, Inc, Sanaflu

SANAFLU XTRA - Trademark Details

Classification Information

005 - Pharmaceutical, veterinary and sanitary preparations; dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides. - Pharmaceutical, veterinary and sanitary preparations; dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for stopping teeth, dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides.

006, 018, 044, 046, 051, 052

Kenalog Injection Uses, Side Effects, Interactions, Pictures, Warnings - Dosing, Kenalog

Kenalog injection

Uses

This medication is used in a variety of conditions such as allergic disorders, arthritis. blood diseases, breathing problems. certain cancers, eye diseases, intestinal disorders, collagen and skin diseases. Talk to your doctor about the risks and benefits of triamcinolone. especially if it is to be injected near your spine (epidural ). Rare but serious side effects may occur with epidural use.

Triamcinolone acetonide is known as a corticosteroid hormone (glucocorticoid). It works by decreasing your body's immune response to these diseases and reduces symptoms such as swelling.

How to use Kenalog injection

This medication may be given by injecting into different locations such as a muscle (intramuscularly), a skin lesion (intradermally), or a joint (intra-articularly). Injections are usually given by a trained healthcare professional. If you are giving yourself intramuscular injection, you will be taught by your healthcare professional on how to properly use this medication. If any of the information is unclear, consult your healthcare professional.

The injection site, schedule, dosage, and length of treatment are based on your medical condition and response to treatment. Do not inject this medication into a vein (intravenously) or into the spine (epidurally). This medication is not recommended for injection around/into the eye or certain parts of the nose due to the risk for blindness or damage to the eye (s). Consult your doctor for more details.

Use this medication and follow the dosing schedule exactly as directed by your doctor in order to get the most benefit from it. Do not change your dose or use this medication for a longer time than prescribed. Be sure to ask your doctor or pharmacist if you have any questions about your treatment.

Wash hands with soap and water before using this medication. Before using, check this product visually for clumpy particles or discoloration. If either is present, do not use the liquid.

Before injecting each dose intramuscularly, clean the injection site with rubbing alcohol. It is important to change the location of the injection site to avoid discomfort or problem areas. Your dose may need to be gradually decreased to reduce symptoms such as weakness. weight loss. nausea. and extreme fatigue .

Shake vial before use to evenly disperse the suspension. Inject the prescribed dose immediately after withdrawing it into the syringe to avoid settling of the medication in the syringe.

Learn how to store and discard syringes, needles, and medical supplies safely. Consult your pharmacist for more information.

If you have been using this medication for a long time, do not suddenly stop it without your doctor's approval. Some conditions may become worse when this drug is suddenly stopped.

This medication may be injected into a joint to treat conditions such as arthritis and bursitis. If you have received an injection into a joint, be careful how much stress you put on that joint, even if it is feeling better. Ask your doctor how much you can move the joint while it is healing.

Inform your doctor if your condition worsens or if you have new symptoms.

Side Effects

Redness or pain at the injection site, stomach upset, headache. dizziness. menstrual period changes, trouble sleeping. or weight gain may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if any of these unlikely but serious side effects occur: bone pain, easy bruising/bleeding, black stools, vomit that looks like coffee grounds, severe stomach /abdominal pain. increased thirst/urination, fast/pounding/irregular heartbeat. shortness of breath, swelling of the ankles /feet, persistent weight gain, puffy face, unusual hair growth, thinning skin, slow wound healing, signs of infection (e. g. persistent fever /cough /sore throat. painful urination. eye pain /discharge), muscle weakness/pain, mental/mood changes (e. g. mood swings, depression. agitation, confusion), vision changes, seizures. unusual skin growths.

If you have received injection of this medication into the joint, temporary discomfort of the joint may occur. Tell your doctor right away if you have fever, increased/severe pain with swelling of the joint, weakness in the joint, or decreased range of motion in the joint.

A very serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction may include: rash. itching /swelling (especially of the face/tongue /throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before using this medication, tell your doctor or pharmacist if you are allergic to it; or to other corticosteroids (e. g. methylprednisolone ); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: untreated active fungal infections.

If your have a certain bleeding disorder (idiopathic thrombocytopenic purpura ), consult your doctor before injecting this medication into a muscle.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: bleeding problems, history of blood clots, brittle bones (osteoporosis), high blood pressure. certain heart problems (e. g. congestive heart failure ), diabetes, certain eye diseases (e. g. cataracts, herpes infection, glaucoma), kidney disease, current infections (e. g. tuberculosis, threadworm), severe liver disease (cirrhosis), certain mental/mood conditions (e. g. psychosis, depression), head injury, previously infected joint, seizures, stomach/intestinal problems (e. g. diverticulitis, ulcer, ulcerative colitis), thyroid problems, untreated mineral problems (e. g. low potassium or calcium).

This medication may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely.

This medication may mask signs of infection or put you at greater risk of developing very serious infections. Report any injuries or signs of infection (e. g. persistent sore throat/cough/fever, pain during urination, muscle aches) that occur while using this medication or within 12 months after stopping it.

Using corticosteroid medications for a long time can make it more difficult for your body to respond to physical stress. Therefore, before having surgery or emergency treatment, or if you get a serious illness/injury, tell your doctor or dentist that you are using this medication or have used this medication within the past 12 months. Tell your doctor right away if you develop unusual/extreme tiredness or weight loss. If you will be using this medication for a long time, carry a warning card or medical ID bracelet that identifies your use of this medication.

Do not have immunizations, vaccinations, or skin tests while you are using this drug unless specifically directed by your doctor. Avoid contact with people who have recently received oral polio vaccine.

Avoid exposure to chickenpox or measles infection while using this medication. If you are exposed to these infections, seek immediate medical attention.

If you have a history of ulcers or take large doses of aspirin or other arthritis medication, limit alcoholic beverages while using this drug. Alcohol may increase the risk of stomach/intestinal bleeding.

If you have diabetes, this drug may increase your blood sugar levels. Check your blood glucose levels regularly as directed by your doctor. Tell your doctor right away if you have symptoms such as increased thirst and urination. Your anti-diabetic medication or diet may need to be adjusted.

Older adults may be more sensitive to the side effects of this drug, especially confusion, or poorer blood sugar control in diabetics.

This medication may slow down a child's growth if used for a long time. Consult the doctor or pharmacist for more details. See the doctor regularly so your child's height and growth can be checked.

Injecting this medication into a muscle is not recommended for children younger than six years. Consult your doctor for more details.

This medication should be used only when clearly needed during pregnancy. There have been rare reports of harm to an unborn baby when corticosteroids are used during pregnancy. Discuss the risks and benefits with your doctor. Infants born to mothers who have been using this medication for an extended time may have low levels of corticosteroid hormone. Tell your doctor right away if you notice symptoms such as persistent nausea/vomiting, severe diarrhea, or weakness in your newborn.

This medication passes into breast milk. While there have been no reports of harm to nursing infants, consult your doctor before breast-feeding.

Interactions

Your healthcare professionals (e. g. doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop or change the dosage of any medicine before checking with them first.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially: aldesleukin, mifepristone, drugs for diabetes, estrogens (e. g. birth control pills), drugs that can cause bleeding/bruising (including antiplatelet drugs such as clopidogrel, "blood thinners" such as dabigatran/warfarin, NSAIDs such as aspirin/celecoxib/ibuprofen), drugs affecting liver enzymes that remove triamcinolone from your body (rifamycins such as rifampin; certain anti-seizure medications such as phenytoin and phenobarbital), live vaccines, certain herbal products (e. g. licorice).

If your doctor has directed you to take low-dose aspirin for heart attack or stroke prevention (usually at dosages of 81-325 milligrams a day), you should continue taking it unless your doctor instructs you otherwise. Ask your doctor or pharmacist for more details.

This product may interfere with certain lab tests. Make sure laboratory personnel and your doctors know you use this drug.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

Overdose

If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Notes

Do not share this medication with others. Lifestyle changes that help reduce the risk of bone loss (osteoporosis) during long-term therapy include weight-bearing exercise, getting adequate calcium and vitamin D, stopping smoking, and limiting alcohol. Discuss lifestyle changes that might benefit you with your doctor.

Laboratory and/or medical tests (e. g. blood counts, blood glucose/mineral levels, blood pressure, bone density tests, height/weight measurements, eye examinations, x-rays) should be performed periodically to monitor your progress or check for side effects during long-term therapy. Consult your doctor for more details.

If you take this medication for prolonged periods, you should wear or carry identification stating that you are taking it.

Missed Dose

This medication should be used as scheduled. If you miss a dose, contact your doctor or pharmacist for instructions. Do not double the dose to catch up.

Storage

Store at room temperature away from light and moisture. Do not freeze. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Information last revised October 2015. Copyright(c) 2015 First Databank, Inc.

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Veranorm Online Without Prescriptions, Veranorm

Calan is used for treating supraventricular tachycardia, a rhythm disturbance of the heart. It is also used for controlling heart rate response to other rhythm disturbances, specifically atrial fibrillation and atrial flutter. Calan is a calcium channel blocker. It works by slowing the electrical conduction in the heart, slowing heart rate, and/or normalizing heart rhythm.

Use Calan as directed by your doctor.

Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results.

Do not crush, chew, break, or open Calan. Swallow it whole. Breaking or opening the pill may cause too much of the drug to be released at one time.

Do not stop taking this medication without first talking to your doctor. If you stop taking Calan suddenly, your condition may become worse.

If you miss a dose of Calan, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Calan.

Store Calan at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Calan out of the reach of children and away from pets.

Active Ingredient . Verapamil hydrochloride.

Do NOT use Calan if:

you are allergic to any ingredient in Calan

you have certain heart problems (eg, left ventricular dysfunction, sick sinus syndrome, second - or third-degree heart block and do not have a pacemaker), very low blood pressure, or moderate to severe congestive heart failure (CHF)

you have atrial fibrillation or flutter and a pre-excitation syndrome (extra conduction pathway in the heart), such as Wolff-Parkinson-White (WPW) syndrome or Lown-Ganong-Levine (LGL) syndrome

you have shock due to serious heart problems

you are taking dofetilide, or you have taken disopyramide within the past 48 hours.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Calan. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have heart failure or a recent heart attack with lung congestion, low blood pressure, or heart problems (eg, a very slow heart rate, heart block, heart valve disease)

if you have kidney or liver problems, muscular dystrophy, or a neuromuscular disease

if you are taking another blood pressure medicine or you are being treated for cancer.

Some medicines may interact with Calan. Tell your health care provider if you are taking any other medicines, especially any of the following:

Beta-blockers (eg, propranolol), clonidine, disopyramide, ketolides (eg, telithromycin), macrolides (eg, erythromycin), or ritonavir because they may increase the risk of Calan's side effects

Phenobarbital, rifampin, or St. John's wort because they may decrease Calan's effectiveness

Aldosterone blockers (eg, eplerenone), aspirin, carbamazepine, colchicine, cyclosporine, digoxin, dofetilide, doxorubicin, dronedarone, eletriptan, erythromycin, everolimus, flecainide, HMG-CoA reductase inhibitors (eg, lovastatin, simvastatin), lithium, narcotic pain relievers (eg, fentanyl), paclitaxel, quinazolines (eg, terazosin), quinidine, ranolazine, theophyllines, or tolvaptan because the risk of their side effects may be increased by Calan.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Calan may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Calan may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Calan with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Calan; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.

Calan may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.

Tell your doctor or dentist that you take Calan before you receive any medical or dental care, emergency care, or surgery.

Lab tests, including liver function, kidney function, complete blood cell counts, electrocardiogram (ECG), and blood pressure, may be performed while you use Calan. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Calan with caution in the elderly; they may be more sensitive to its effects.

Calan should not be used in childen; safety and effectiveness in children have not been confirmed.

Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Calan while you are pregnant. Calan is found in breast milk. If you are or will be breast-feeding while you use Calan, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Dizziness; fatigue; headache; lightheadedness.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; fainting; lightheadedness, especially when standing; severe dizziness; shortness of breath; swelling of the feet or hands; symptoms of liver problems (eg, yellowing of the skin or eyes, dark urine, pale stools, severe or persistent stomach pain, fever, general feeling of being unwell); unusually fast, slow, or irregular heartbeat.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Digoxin $0.47 for pill Digoxin is used for treating heart failure and slowing the heart rate in patients with chronic atrial fibrillation, a type of abnormal heart rhythm. More info Betapace $0.82 for pill Betapace is used for treating certain types of irregular heartbeat (ventricular arrhythmias). More info

Prinivil $0.23 for pill Prinivil is used for treating high blood pressure alone or with other medicines. More info Atorlip-10 $0.83 for pill Atorlip-10 is used to treat high cholesterol. More info

Prilozheniya Na Google Play – Memorit Reminder, Memorit

Описание

Remember anything, anywhere, anytime, anyone!

Memorit is a reminder app that can set reminders to trigger not only on time, but also on nearby (5-10 m) friends or any location. You can also send reminders to friends.

Please note. - Memorit requires Facebook login for robust contact alarm triggering. If you don't use Facebook, then please don't install Memorit, and please don't rate it. - Memorit requires Bluetooth to be turned on and visible without timeout. There is a bug in Android which prevents Memorit from setting no timeout on some phones. If you don't want Bluetooth turned on, then please don't install Memorit, and please don't rate it. - Memorit requires periodic background processing. Battery savers that kill or pause background processes, e. g. stamina mode on Xperia, should be configured to not kill or pause Memorit.

Memorit is an application developed as part of the Proximates research project at Lund University in partnership with Venturus institute in Brazil. By simply using the application you participate and contribute to a research project.

Запомнить ничего, в любом месте, в любое время, любой!

Memorit является напоминанием приложение, которое можно установить напоминания, чтобы вызвать не только от времени, но и на территории (5-10 м) друзей или в любом месте. Вы также можете направить напоминания друзей.

Обратите внимание. - Memorit требуется Facebook логин для надежной контактной тревожной сигнализации. Если вы не используете Facebook, то, пожалуйста, не устанавливайте Memorit, и пожалуйста, не оценить его. - Memorit требуется Bluetooth должен быть включен и видна без тайм-аута. Существует ошибка в Android, который предотвращает Memorit от не установив отсутствие таймаута на некоторых телефонах. Если вы не хотите Bluetooth включен, то, пожалуйста, не устанавливайте Memorit, и пожалуйста, не оценить его. - Memorit требуется периодической фоновой обработки. Хранители батарей, которые убивают или паузы фоновые процессы, например, Режим выносливость на Xperia, должен быть настроен на не убить или приостановить Memorit.

Memorit это приложение, разработанное в рамках научно-исследовательского проекта аппроксимирует Университета Лунда в партнерстве с Venturus института в Бразилии. Просто с помощью приложения вы участвовать и вносить вклад в научно-исследовательский проект.

Отзывы

Что нового

Дополнительная информация

Похожие

Описание

Remember anything, anywhere, anytime, anyone!

Memorit is a reminder app that can set reminders to trigger not only on time, but also on nearby (5-10 m) friends or any location. You can also send reminders to friends.

Please note. - Memorit requires Facebook login for robust contact alarm triggering. If you don't use Facebook, then please don't install Memorit, and please don't rate it. - Memorit requires Bluetooth to be turned on and visible without timeout. There is a bug in Android which prevents Memorit from setting no timeout on some phones. If you don't want Bluetooth turned on, then please don't install Memorit, and please don't rate it. - Memorit requires periodic background processing. Battery savers that kill or pause background processes, e. g. stamina mode on Xperia, should be configured to not kill or pause Memorit.

Memorit is an application developed as part of the Proximates research project at Lund University in partnership with Venturus institute in Brazil. By simply using the application you participate and contribute to a research project.

Запомнить ничего, в любом месте, в любое время, любой!

Memorit является напоминанием приложение, которое можно установить напоминания, чтобы вызвать не только от времени, но и на территории (5-10 м) друзей или в любом месте. Вы также можете направить напоминания друзей.

Обратите внимание. - Memorit требуется Facebook логин для надежной контактной тревожной сигнализации. Если вы не используете Facebook, то, пожалуйста, не устанавливайте Memorit, и пожалуйста, не оценить его. - Memorit требуется Bluetooth должен быть включен и видна без тайм-аута. Существует ошибка в Android, который предотвращает Memorit от не установив отсутствие таймаута на некоторых телефонах. Если вы не хотите Bluetooth включен, то, пожалуйста, не устанавливайте Memorit, и пожалуйста, не оценить его. - Memorit требуется периодической фоновой обработки. Хранители батарей, которые убивают или паузы фоновые процессы, например, Режим выносливость на Xperia, должен быть настроен на не убить или приостановить Memorit.

Memorit это приложение, разработанное в рамках научно-исследовательского проекта аппроксимирует Университета Лунда в партнерстве с Venturus института в Бразилии. Просто с помощью приложения вы участвовать и вносить вклад в научно-исследовательский проект.

Отзывы

Что нового

Дополнительная информация

Похожие

Drilyna, Drilyna

Colombia

DRILYNA пїЅ

ComposiciпїЅn.

DRILYNA пїЅ CпїЅpsulas, cada cпїЅpsula contiene 5 mg de Levocetirizina Diclorhidrato. DRILYNA пїЅ Jarabe, cada 5 mL contiene 2.50 mg de Levocetirizina Diclorhidrato.

Indicaciones.

DRILYNA пїЅ estпїЅ indicada para el manejo de sпїЅntomas asociados a enfermedades alпїЅrgicas como: Rinitis alпїЅrgica estacional (incluyendo sпїЅntomas oculares), Rinitis alпїЅrgica perenne, Urticaria crпїЅnica idiopпїЅtica.

DosificaciпїЅn.

Las CпїЅpsulas Blandas de Gelatina (CBG) se administra por vпїЅa oral, tragпїЅndola entera con ayuda de lпїЅquidos y se puede tomar tanto en ayunas como con alimentos.

Contraindicaciones.

Historia de hipersensibilidad a la Levocetirizina o a cualquier otro componente de la formulaciпїЅn o a cualquier derivado piperazпїЅnico. Pacientes con enfermedad renal terminal con una aclaraciпїЅn de creatinina inferior a 10 mL/min. Los pacientes con problemas de intolerancia a la galactosa, deficiencia de lactosa o mal absorciпїЅn de glucosa-galactosa no deberпїЅan tomar este medicamento. Precauciones y advertencias especiales: No se recomienda utilizar DRILYNA пїЅ en menores de un aпїЅo ya que no hay evidencia que demuestre su seguridad en estos pacientes. Se recomienda precauciпїЅn con la ingesta de alcohol en pacientes adultos. Embarazo y lactancia: Aunque los datos disponibles sobre un nпїЅmero limitado de embarazadas indican que Levocetirizina no tiene efectos adversos sobre el embarazo o sobre la salud del feto/reciпїЅn nacido, se deberпїЅn tomar precauciones al prescribirse a mujeres embarazadas. Se espera que la Levocetirizina se excrete por la leche materna, por lo que no se recomienda su uso durante la lactancia a menos que el beneficio sobre la madre sea mayor que cualquier riesgo teпїЅrico sobre el hijo.

Reacciones adversas.

En los estudios clпїЅnicos se observaron las siguientes reacciones adversas relacionadas con el fпїЅrmaco y con una incidencia igual o superior al 1% (comпїЅn: > 1/100, 1/1.000, пїЅ CпїЅpsula blanda de gelatina, caja por 10 cпїЅpsulas en blпїЅster PVDC/Aluminio (Reg. INVIMA 2009M-0009418). DRILYNA пїЅ Jarabe Frasco x 120 ml (Reg. INVIMA 2012M-0013619).

Further Recall Of Paracetamol Tablets, Paratabs

Further recall of paracetamol tablets

The Irish Medicines Board (IMB) has issued an urgent notice for patients who have been dispensed any batch of the paracetamol product, Paratabs 500mg Tablets.

This announcement is an extension of a recall announced last month, in which one batch of the tablets was recalled due to fears of contamination. Since then, 'contamination of several additional batches' has been identified. The cause of this contamination is being investigated, but it is likely to be a mould.

Paratabs 500mg Tablets could not have been purchased over the counter in grocery stores or in pharmacies. They would only have been dispensed by your pharmacist on foot of a prescription from your doctor.

Blister pack of Paratabs or other paracetamol products are not affected.

Details of the product distributed in Ireland are as follows:

-Product name: Paratabs 500mg Tablets.

-Active substance: Paracetamol.

-PA number: PA281/74/1.

-Batch number: 6022.

-Expiry date: 02/2008.

-Marketing authorisation holder: Pinewood Laboratories Ltd (trading as Pinewood Healthcare).

The IMB is calling on all patients who have been dispensed Paratabs 500mg Tablets since August 29 to immediately check the label of their drugs to see if they are part of the affected batch.

If they are, or if you are unsure about the drugs you have been dispensed, do not take any more of the tablets. Return them immediately to the pharmacist, who will be able to dispense alternative paracetamol tablets.

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Your #1 Choice For Boats For Sale In Maine, Glucofine

Your #1 Choice for Boats for Sale in Maine

Hamlin’s Marine wants you to enjoy every moment on the water.

For over twenty years Hamlin’s Marine has delivered on a simple promise… ”If you purchase a boat from Hamlin’s Marine, we’ll always be there when you need us.” Hamlin’s Marine offers convenience and assurance with our locations in Waterville and Hampden, staff of twenty-five dedicated employees, and a fleet of service trucks.

At Hamlin’s we only sell boats that we can stand behind. Our manufacturers include Bennington Pontoons. Stingray. Mastercraft. Cutwater. Northcoast. Puffin. Alumacraft. Achilles. Scout Boats. and Yamaha Outboards. These manufacturers lead the industry in quality construction, and make it easier to serve you when it matters most.

So come on in and choose from our selection of new and used Pontoon Boats, Tow Boats or any other fishing boats or family fun boats. With two easy locations in Waterville, Maine (Boat Sales and Service) or Hampden, Maine (Boat Sales, Service, and Marina) it couldn't get any more convenient. Choose Hamlin’s Marine as your boat dealer, service center, marina, and indoor storage facility, and we promise you’ll make wonderful memories on the water in Maine.

At Hamlin's Marine we stand behind all of our boats for sale in Maine .

Why Buy From Hamlin's Marine:

31 Years in Business

#1 Yamaha Outboard Dealer in New England for 5 Years in a Row

Alumacraft is America's #1 selling Deep V Aluminum Fishing Boat

Multiple Locations to serve you

Fleet of ten service and delivery trucks

Critica Profesional A Los Comerciales Analper - Fem, Plus Y Forte (Venezuela), Analper

yo tome ANALPER PLUS como antiespasmodico y cuando tome la tercera dosis, a los 45 min, me produjo una reaccion en donde se inflamo mi globo ocular izq. casi para explotar, no debe verse la parte publicitaria sino tambien los efectos secundarios y sus consecuencias, ahora tengo dolores de cabeza sin razon aparente

yo tome ANALPER PLUS como antiespasmodico y cuando tome la tercera dosis, a los 45 min, me produjo una reaccion en donde se inflamo mi globo ocular izq. casi para explotar, no debe verse la parte publicitaria sino tambien los efectos secundarios y sus consecuencias, ahora tengo dolores de cabeza sin razon aparente

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Ecofenac Generic Name Diclofenac Online, Ecofenac

Ecofenac General Information

Ecofenac - Pharmacology:

The antiinflammatory effects of diclofenac are believed to be due to inhibition of both leukocyte migration and the enzyme cylooxygenase (COX-1 and COX-2), leading to the peripheral inhibition of prostaglandin synthesis. As prostaglandins sensitize pain receptors, inhibition of their synthesis is responsible for the analgesic effects of ketoprofen. Antipyretic effects may be due to action on the hypothalamus, resulting in peripheral dilation, increased cutaneous blood flow, and subsequent heat dissipation.

Ecofenac for patients

Ecofenac, like other drugs of its class, is not free of side effects. The side effects of these drugs can cause discomfort and rarely, more serious side effects, such as gastrointestinal bleeding, and more rarely, liver toxicity which may result in hospitalization and even fatal outcomes.

NSAIDs are often essential agents in the management of arthritis and have a major role in the management of pain, but they also may be commonly employed for conditions that are less serious.

Physicians may w. s. to discuss with their patients the potential risks and likely benefits of NSAID treatment, particularly when the drugs are used for less serious conditions where treatment without NSAIDs may represent an acceptable alternative to both the patient and physician.

Because serious G. I. tract ulceration and bleeding can occur without warning symptoms, physicians should follow chronically treated patients for the signs and symptoms of ulceration and bleeding and should inform them of the importance of this follow-up. If diclofenac is used chronically, patients should also be instructed to report any signs and symptoms that might be due to hepatotoxicity of dictofenac; these symptoms may become evident between visits when periodic liver laboratory tests are performed

This description is suitable for active ingredient Diclofenac

Ecofenac Interactions

Aspirin: Concomitant administration of diclofenac and aspirin is not recommended because diclofenac is displaced from its binding sites during the concomitant administration of aspirin, resulting in lower plasma concentrations, peak plasma levels, and AUC values.

Anticoagulants: While studies have not shown diclofenac to interact with anticoagulants of the warfarin type, caution should be exercised, nonetheless, since interactions have been seen with other NSAIDs. Because prostaglandins play an important role in hemostasis, and NSAIDs affect platelet function as well, concurrent therapy with all NSAIDs, including diclofenac, and warfarin requires close monitoring of patients to be certain that no change in their anticoagulant dosage is required.

Digoxin, Methotrexate, Cyclosporine: Ecofenac, like other NSAIDs, may affect renal prostaglandins and increase the toxicity of certain drugs. Ingestion of diclofenac may increase serum concentrations of digoxin and methotrexate and increase cyclosporineis nephrotoxicity. Patients who begin taking diclofenac or who increase their diclofenac dose or any other NSAID while taking digoxin, methotrexate, or cyclosporine may develop toxicity characteristics for these drugs. They should be observed closely, particularly if renal function is impaired. In the case of digoxin, serum levels should be monitored.

Lithium: Ecofenac decreases lithium renal clearance and increases lithium plasma levels. In patients taking diclofenac and lithium concomitantly, lithium toxicity may develop.

Oral Hypoglycemics: Ecofenac does not alter glucose metabolism in normal subjects nor does it alter the effects of oral hypoglycemic agents. There are rare reports, however, from marketing experiences, of changes in effects of insulin or oral hypoglycemic agents in the presence of diclofenac that necessitated changes in the doses of such agents. Both hypo - and hyperglycemic effects have been reported. A direct causal relationship has not been established, but physicians should consider the possibility that diclofenac may alter a diabetic patientis response to insulin or oral hypoglycemic agents.

Diuretics: Ecofenac and other NSAIDs can inhibit the activity of diuretics. Concomitant treatment with potassium-sparing diuretics may be associated with increased serum potassium levels.

Other Drugs: In small groups of patients (7-10/interaction study), the concomitant administration of azathioprine, gold, chloroquine, D-penicillamine, prednisolone, doxycycline, or digitoxin did not significantly affect the peak levels and AUC values of diclofenac. Phenobarbital toxicity has been reported to have occurred in a patient on chronic phenobarbital treatment following the initiation of diclofenac therapy.

In vitro, diclofenac interferes minimally or not at all with the protein binding of salicylic acid (20% decrease in binding), tolbutamide, prednisolone (10% decrease in binding), or warfarin. Benzylpenicillin, ampicillin, oxacillin, chlortetracycline, doxycycline, cephalothin, erythromycin, and sulfamethoxazole have no influence in vitro on the protein binding of diclofenac in human serum.

Drug/Laboratory Test Interactions

Effect on Blood Coagulation: Ecofenac increases platelet aggregation time but does not affect bleeding time, plasma thrombin clotting time, plasma fibrinogen, or factors V and VII to XII. Statistically significant changes in prothrombin and partial thromboplastin times have been reported in normal volunteers. The mean changes were observed to be less than 1 second in both instances, however, and are unlikely to be clinically important. Ecofenac is a prostaglandin synthetase inhibitor, however, and all drugs that inhibit prostaglandin synthesis interfere with platelet function to some degree; therefore, patients who may be adversely affected by such an action should be carefully observed.

Ecofenac Contraindications

Ecofenac in all formulations, Cataflam, Voltaren, and Voltaren-XR, is contraindicated in patients with known hypersensitivity to diclofenac and diclofenac-containing products. Ecofenac should not be given to patients who have experienced asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal, anaphylactic-like reactions to diclofenac have been reported in such patients.

This description is suitable for active ingredient Diclofenac

Generic name, Overdose, Half Life Ecofenac, Food Interactions, Chemical, etc..

Ecofenac see also

Ecofenac General Information

Ecofenac - Pharmacology:

The antiinflammatory effects of diclofenac are believed to be due to inhibition of both leukocyte migration and the enzyme cylooxygenase (COX-1 and COX-2), leading to the peripheral inhibition of prostaglandin synthesis. As prostaglandins sensitize pain receptors, inhibition of their synthesis is responsible for the analgesic effects of ketoprofen. Antipyretic effects may be due to action on the hypothalamus, resulting in peripheral dilation, increased cutaneous blood flow, and subsequent heat dissipation.

Ecofenac for patients

Ecofenac, like other drugs of its class, is not free of side effects. The side effects of these drugs can cause discomfort and rarely, more serious side effects, such as gastrointestinal bleeding, and more rarely, liver toxicity which may result in hospitalization and even fatal outcomes.

NSAIDs are often essential agents in the management of arthritis and have a major role in the management of pain, but they also may be commonly employed for conditions that are less serious.

Physicians may w. s. to discuss with their patients the potential risks and likely benefits of NSAID treatment, particularly when the drugs are used for less serious conditions where treatment without NSAIDs may represent an acceptable alternative to both the patient and physician.

Because serious G. I. tract ulceration and bleeding can occur without warning symptoms, physicians should follow chronically treated patients for the signs and symptoms of ulceration and bleeding and should inform them of the importance of this follow-up. If diclofenac is used chronically, patients should also be instructed to report any signs and symptoms that might be due to hepatotoxicity of dictofenac; these symptoms may become evident between visits when periodic liver laboratory tests are performed

This description is suitable for active ingredient Diclofenac

Ecofenac Interactions

Aspirin: Concomitant administration of diclofenac and aspirin is not recommended because diclofenac is displaced from its binding sites during the concomitant administration of aspirin, resulting in lower plasma concentrations, peak plasma levels, and AUC values.

Anticoagulants: While studies have not shown diclofenac to interact with anticoagulants of the warfarin type, caution should be exercised, nonetheless, since interactions have been seen with other NSAIDs. Because prostaglandins play an important role in hemostasis, and NSAIDs affect platelet function as well, concurrent therapy with all NSAIDs, including diclofenac, and warfarin requires close monitoring of patients to be certain that no change in their anticoagulant dosage is required.

Digoxin, Methotrexate, Cyclosporine: Ecofenac, like other NSAIDs, may affect renal prostaglandins and increase the toxicity of certain drugs. Ingestion of diclofenac may increase serum concentrations of digoxin and methotrexate and increase cyclosporineis nephrotoxicity. Patients who begin taking diclofenac or who increase their diclofenac dose or any other NSAID while taking digoxin, methotrexate, or cyclosporine may develop toxicity characteristics for these drugs. They should be observed closely, particularly if renal function is impaired. In the case of digoxin, serum levels should be monitored.

Lithium: Ecofenac decreases lithium renal clearance and increases lithium plasma levels. In patients taking diclofenac and lithium concomitantly, lithium toxicity may develop.

Oral Hypoglycemics: Ecofenac does not alter glucose metabolism in normal subjects nor does it alter the effects of oral hypoglycemic agents. There are rare reports, however, from marketing experiences, of changes in effects of insulin or oral hypoglycemic agents in the presence of diclofenac that necessitated changes in the doses of such agents. Both hypo - and hyperglycemic effects have been reported. A direct causal relationship has not been established, but physicians should consider the possibility that diclofenac may alter a diabetic patientis response to insulin or oral hypoglycemic agents.

Diuretics: Ecofenac and other NSAIDs can inhibit the activity of diuretics. Concomitant treatment with potassium-sparing diuretics may be associated with increased serum potassium levels.

Other Drugs: In small groups of patients (7-10/interaction study), the concomitant administration of azathioprine, gold, chloroquine, D-penicillamine, prednisolone, doxycycline, or digitoxin did not significantly affect the peak levels and AUC values of diclofenac. Phenobarbital toxicity has been reported to have occurred in a patient on chronic phenobarbital treatment following the initiation of diclofenac therapy.

In vitro, diclofenac interferes minimally or not at all with the protein binding of salicylic acid (20% decrease in binding), tolbutamide, prednisolone (10% decrease in binding), or warfarin. Benzylpenicillin, ampicillin, oxacillin, chlortetracycline, doxycycline, cephalothin, erythromycin, and sulfamethoxazole have no influence in vitro on the protein binding of diclofenac in human serum.

Drug/Laboratory Test Interactions

Effect on Blood Coagulation: Ecofenac increases platelet aggregation time but does not affect bleeding time, plasma thrombin clotting time, plasma fibrinogen, or factors V and VII to XII. Statistically significant changes in prothrombin and partial thromboplastin times have been reported in normal volunteers. The mean changes were observed to be less than 1 second in both instances, however, and are unlikely to be clinically important. Ecofenac is a prostaglandin synthetase inhibitor, however, and all drugs that inhibit prostaglandin synthesis interfere with platelet function to some degree; therefore, patients who may be adversely affected by such an action should be carefully observed.

Ecofenac Contraindications

Ecofenac in all formulations, Cataflam, Voltaren, and Voltaren-XR, is contraindicated in patients with known hypersensitivity to diclofenac and diclofenac-containing products. Ecofenac should not be given to patients who have experienced asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal, anaphylactic-like reactions to diclofenac have been reported in such patients.

This description is suitable for active ingredient Diclofenac

Generic name, Overdose, Half Life Ecofenac, Food Interactions, Chemical, etc..

Ecofenac see also

Femtozone, Femtozone

Femtozone Applications

Bringing My Mobile Life Home, Bringing My Home Life to My Mobile

Beyond the “traditional” business drivers of improved indoor coverage and capacity savings, femtocells have a strong appeal as a delivery platform for a new class of value-added services. These services are referred to as femtozone services to distinguish them from the “vanilla” voice and data access services provided by the femtocell.

Femtocells are strategically located in the home and they are the only devices that are part of both the home network and the operator’s network. As such, they can play a crucial role in the home by bridging mobile and home devices and enabling a new class of tightly-converged services.

Femtozone Service Library

The femtozone service ecosystem is still at a nascent stage. However, several examples of femtozone applications are already available in various forms. A few of these services are starting to be commercially deployed.

In the following, we provide short summaries and links to some of the basic femtozone service examples, to give an idea of the type of services enabled by the femtocell.

Family Alert Service: When a family member arrives home or leaves, the femtocell automatically sends an SMS message. For example, a parent at work can be notified that their child has arrived home from school.

Virtual Home Number: A “home” phone number that rings on all the handsets at home when a call comes in to that number.

Media Synchronization: Ability to synchronize music tracks and video clips automatically between a mobile handset and a home PC.

Photo Upload: Ability to upload photos automatically from the handset to a home PC when handset arrives home and display the photos to a digital picture frame.

Contact/Calendar Synchronization: Ability to synchronize handset calendar/contacts with home personal and family calendars/contacts every time the handset arrives home.

Remote Control: Ability of the mobile phone to function as a remote control for home devices (DVR, DVD, TV) when it is in the home.

Mobile Video: Ability to stream videos from DVR/DVD player directly to your mobile phone.

Family Tablet: Ability to enable a group of family communication features on an in-home display to show the geographic locations of household members, display household calendar and reminder messages, access voicemail and text messages, and store and display pictures from the mobile phone.

Point-of-Sale promotion: Femtocells in retail spaces allow merchants to detect customers’ presence and provide welcome messages, coupons, and store directory services.

Virtual PBX: In an office setting, the femtocell combined with IP-PBX software on the corporate network can make mobile phones into virtual extensions on the office phone system.

The Seven Unique Traits of the Femtocell

Femtocell as a Game-Changing Device in the Connected Digital Home

Femtocells are potentially game-changing devices in the connected digital home, as they can play a major role in home entertainment services, family communications, and converged services.

Femtocells can enable new services because they have seven unique traits that set them apart from all the other devices in the home in terms of service delivery. They are:

Trait 1. Mobile/Home Network Bridging

Trait 2. Presence

Trait 3. Universal Anchor to Home Network

Trait 4. Managed Service Delivery Platform

Trait 5. Local Traffic Injection Point

Trait 6. Transparent Mobile Broadband

Trait 7. Social Networking Tool

Femtocell: A Unique Device Service Delivery Platform in the Connected Digital Home

When taken individually, each of the seven unique traits can potentially be achieved by other devices in the home. When thinking about each of these aspects in more detail, however, it becomes apparent that the femtocell can provide this functionality in a much more straightforward and natural manner than any other device in the home.

The great appeal and potential of the femtocell is therefore in the “package” of these characteristics. Each of these traits can be taken advantage of, individually or in combination, to create a new class of femtozone services. The following table gives a few representative examples of how each trait enables unique services.

Of course, these are just some basic examples of new femtozone services. As the femtozone service ecosystem is put in motion and a community of application developers is formed, we will see many more exciting applications that take advantage of the unique capabilities provided by the femtocell.

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Losar Date 2016 - When Is Losar 2016, Losar

When is Losar

Losar is considered to be the most significant festival of the Buddhist community in Tibet. The festival marks the Tibetan New Year and is celebrated with great splendor and grandeur. The word Losar has been derived from two Tibetan words, ?lo' meaning ?year' and ?sar' meaning ?new'. The Tibetan Buddhists observe the festival to ward off evil spirits and welcome the arrival of the New Year filled with happiness and prosperity. Though the Tibetan New Year is celebrated on the first day of the first month of the Tibetan lunar calendar, the date varies each year. Glance through the lines below to know the date of Losar festival in the year 2016.

When Is Tibetan New Year In 2016 The Tibetans follow the lunisolar calendar, which means that the date is indicative of the moon phase and the time of the solar year as well. Losar, the Tibetan New Year is celebrated on the first day of the first month of the calendar. The date usually falls in the months of January, February or March according to the Gregorian calendar. The date of this festival is likely to fall on Monday Feb 08 in the year 2016. The festival is celebrated from the first to the third of the first lunar month. Marked with immense opulence and radiance, some people even continue with their celebrations for the next ten to fifteen days as well.

The celebrations of the Tibetan New Year begin on the 29th day of the twelfth month, that is, the day before the Tibetan New Year's Eve. People get occupied with cleaning their homes and painting them new. The houses are adorned with different decorations and offerings are made known as ?Lama Losar'. On the New Year's Eve, a traditional noodle soup is made called guthuk. It contains dumplings made from flour and water. The dumplings are stuffed with each of nine different fortune symbols that determine the fortune of the person in the next year.

On the New Year's Day, people rise early and dress in their finest and new clothes. They make offerings to the household shrine to pay homage to the God. This day is restricted to the immediate family members only. On the second day, people move out and visit friends and relatives. They exchange greetings and wish one another ?tashi delek', which means ?good luck'. In the evening, people lit torches and move around in their homes warding off evil spirits from their abodes. The third day is marked by visits to the monasteries, shrines and stupas. Clothes and food are donated to the monks and nuns. Back home, different traditional foods are made to celebrate the occasion.

Losar 2016: Monday Feb 08

Erphathrocin, Erphathrocin

Erythromycin

Click for further information on drug naming conventions and International Nonproprietary Names .

Important Notice: The Drugs. com international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

Product Description Common use Erythromycin is in a group of drugs called macrolide antibiotics. Erythromycin is used to treat many different types of infections caused by bacteria. It is also used to prevent bacterial endocarditis and attacks of rheumatic fever.

Dosage and direction Take erythromycin exactly as it was prescribed for you. Take each dose with a full glass (8 ounces) of water. Erythromycin can be taken on an empty stomach or with food or milk. Do not crush, chew, break, or open an enteric-coated or delayed-release pill. Swallow the pill whole.

Precautions Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.

Contraindications Do not use this medication if you are allergic to erythromycin, or if you are also taking cisapride (Propulsid) or pimozide (Orap). If you have liver disease or myasthenia gravis, you may need a dose adjustment or special tests to safely take erythromycin. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Erythromycin can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Possible side effects Get emergency medical help if you have any of these signs of an allergic reaction to erythromycin: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects: chest pain, uneven heartbeats, feeling light-headed or fainting; nausea, stomach pain, low fever, lost appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or diarrhea that is watery or bloody. Less serious erythromycin side effects may include: mild nausea, vomiting, diarrhea, or stomach pain; dizziness, headache, feeling tired; vaginal itching or discharge; or mild itching or skin rash.

Drug interaction Many drugs can interact with erythromycin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Missed dose Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

Overdose Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include nausea, vomiting, diarrhea, stomach pain, or hearing loss.

Storage Store this medication at room temperature away from moisture and heat.

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. The specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Product Description Common use Erythromycin is in a group of drugs called macrolide antibiotics. Erythromycin is used to treat many different types of infections caused by bacteria. It is also used to prevent bacterial endocarditis and attacks of rheumatic fever.

Dosage and direction Take erythromycin exactly as it was prescribed for you. Take each dose with a full glass (8 ounces) of water. Erythromycin can be taken on an empty stomach or with food or milk. Do not crush, chew, break, or open an enteric-coated or delayed-release pill. Swallow the pill whole.

Precautions Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.

Contraindications Do not use this medication if you are allergic to erythromycin, or if you are also taking cisapride (Propulsid) or pimozide (Orap). If you have liver disease or myasthenia gravis, you may need a dose adjustment or special tests to safely take erythromycin. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Erythromycin can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Possible side effects Get emergency medical help if you have any of these signs of an allergic reaction to erythromycin: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects: chest pain, uneven heartbeats, feeling light-headed or fainting; nausea, stomach pain, low fever, lost appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or diarrhea that is watery or bloody. Less serious erythromycin side effects may include: mild nausea, vomiting, diarrhea, or stomach pain; dizziness, headache, feeling tired; vaginal itching or discharge; or mild itching or skin rash.

Drug interaction Many drugs can interact with erythromycin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Missed dose Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

Overdose Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include nausea, vomiting, diarrhea, stomach pain, or hearing loss.

Storage Store this medication at room temperature away from moisture and heat.

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. The specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Product Description Common use Erythromycin is in a group of drugs called macrolide antibiotics. Erythromycin is used to treat many different types of infections caused by bacteria. It is also used to prevent bacterial endocarditis and attacks of rheumatic fever.

Dosage and direction Take erythromycin exactly as it was prescribed for you. Take each dose with a full glass (8 ounces) of water. Erythromycin can be taken on an empty stomach or with food or milk. Do not crush, chew, break, or open an enteric-coated or delayed-release pill. Swallow the pill whole.

Precautions Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.

Contraindications Do not use this medication if you are allergic to erythromycin, or if you are also taking cisapride (Propulsid) or pimozide (Orap). If you have liver disease or myasthenia gravis, you may need a dose adjustment or special tests to safely take erythromycin. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Erythromycin can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Possible side effects Get emergency medical help if you have any of these signs of an allergic reaction to erythromycin: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects: chest pain, uneven heartbeats, feeling light-headed or fainting; nausea, stomach pain, low fever, lost appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or diarrhea that is watery or bloody. Less serious erythromycin side effects may include: mild nausea, vomiting, diarrhea, or stomach pain; dizziness, headache, feeling tired; vaginal itching or discharge; or mild itching or skin rash.

Drug interaction Many drugs can interact with erythromycin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Missed dose Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

Overdose Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include nausea, vomiting, diarrhea, stomach pain, or hearing loss.

Storage Store this medication at room temperature away from moisture and heat.

Disclaimer We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. The specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

Buy Cardiocor Online - Self Healing Centre, Cardiocor

Cardiocor

Medication guide about Cardiocor (Bisoprolol)

Brand name: Cardiocor Generic name: Bisoprolol

What is the most important information I should know about Cardiocor? Do not stop taking Cardiocor without first talking to your doctor. Stopping suddenly may make your condition worse. If you need to have any type of surgery, you may need to temporarily stop using Cardiocor. Be sure the surgeon knows ahead of time that you are using Cardiocor. Cardiocor can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol, which could increase drowsiness and dizziness while you are taking Cardiocor. Cardiocor is only part of a complete program of treatment for hypertension that may also include diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely if you are being treated for hypertension. Hypertension often has no symptoms, so you may not even feel that you have high blood pressure. Continue using this medicine as directed, even if you feel well. You may need to use blood pressure medication for the rest of your life.

What is Cardiocor? Cardiocor is in a group of drugs called beta-blockers. Beta-blockers affect the heart and circulation (blood flow through arteries and veins). Cardiocor is used to treat hypertension (high blood pressure). Cardiocor may also be used for purposes other than those listed in this medication guide.

What should I discuss with my healthcare provider before taking Cardiocor? Before taking Cardiocor, tell your doctor if you have: asthma, bronchitis, emphysema; diabetes; low blood pressure; a heart problem such as heart block, sick sinus syndrome, slow heart rate, or congestive heart failure; depression; liver or kidney disease; a thyroid disorder; myasthenia gravis; pheochromocytoma; or problems with circulation (such as Raynaud’s syndrome). If you have any of these conditions, you may not be able to use Cardiocor, or you may need a dosage adjustment or special tests during treatment. FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether Cardiocor passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take Cardiocor? Take Cardiocor exactly as it was prescribed for you. Do not take the medication in larger amounts or for longer than recommended by your doctor. Take this medication with a full glass of water. Take Cardiocor at the same time every day. Do not skip doses or stop taking Cardiocor without first talking to your doctor. Stopping suddenly may make your condition worse. To be sure this medication is helping your condition, your blood pressure will need to be checked on a regular basis. It is important that you not miss any scheduled visits to your doctor. If you need to have any type of surgery, tell the surgeon that you are using Cardiocor. You may need to briefly stop using Cardiocor before having surgery. Cardiocor is only part of a complete program of treatment for hypertension that may also include diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely if you are being treated for hypertension. Hypertension often has no symptoms, so you may not even feel that you have high blood pressure. Continue using this medicine as directed, even if you feel well. You may need to use blood pressure medication for the rest of your life. Store Cardiocor at room temperature away from moisture and heat.

What happens if I miss a dose? Take the missed dose as soon as you remember. If your next dose is less than 4 hours away, skip the the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose? Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of an Cardiocor overdose may include uneven heartbeats, shortness of breath, bluish-colored fingernails, dizziness, weakness, fainting, or seizure (convulsions).

What should I avoid while taking Cardiocor? Cardiocor can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol, which could increase drowsiness and dizziness while you are taking Cardiocor.

What are the possible side effects of Cardiocor? Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects: slow or uneven heartbeats; feeling light-headed, fainting; feeling short of breath, even with mild exertion; swelling of your ankles or feet; nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); depression; or cold feeling in your hands and feet. Other less serious side effects are more likely to occur, such as: decreased sex drive, impotence, or difficulty having an orgasm; sleep problems (insomnia); tired feeling; or anxiety, nervousness. Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect Cardiocor? Before taking Cardiocor, tell your doctor if you are using: allergy treatments (or if you are undergoing allergy skin-testing); clonidine (Catapres); guanabenz (Wytensin); an MAO inhibitor such as isocarboxazid (Marplan), tranylcypromine (Parnate), phenelzine (Nardil), or selegiline (Eldepryl, Emsam); a diabetes medication such as insulin, glyburide (Diabeta, Micronase, Glynase), glipizide (Glucotrol), chlorpropamide (Diabinese), or metformin (Glucophage); a heart medication such as nifedipine (Procardia, Adalat), reserpine (Serpasil), verapamil (Calan, Verelan, Isoptin), diltiazem (Cartia, Cardizem); medicine for asthma or other breathing disorders, such as albuterol (Ventolin, Proventil), bitolterol (Tornalate), metaproterenol (Alupent), pirbuterol (Maxair), terbutaline (Brethaire, Brethine, Bricanyl), and theophylline (Theo-Dur, Theolair); or cold medicines, stimulant medicines, or diet pills. If you are using any of these drugs, you may not be able to take Cardiocor, or you may need dosage adjustments or special tests during treatment. There may be other drugs not listed that can affect Cardiocor. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

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Depo®-Estradiol (Estradiol Cipionate), Depo-Estradiol

DEPO®-ESTRADIOL (estradiol cipionate)

WARNINGS

ESTROGENS INCREASE THE RISK OF ENDOMETRIAL CANCER

Close clinical surveillance of all women taking estrogens is important. Adequate diagnostic measures including endometrial sampling, when indicated, should be undertaken to rule out malignancy in all cases of undiagnosed persistent or recurring abnormal vaginal bleeding. There is currently no evidence that the use of "natural" estrogens results in a different endometrial risk profile than "synthetic" estrogens at equivalent estrogen doses. (See WARNINGS, malignant neoplasms, Endometrial cancer .)

CARDIOVASCULAR AND OTHER RISKS

Estrogens with and without progestins should not be used for the prevention of cardiovascular disease. (See WARNINGS, Cardiovascular disorders .)

The Women's Health Initiative (WHI) study reported increased risks of myocardial infarction, stroke, invasive breast cancer, pulmonary emboli, and deep vein thrombosis in postmenopausal women (50 to 79 years of age) during 5 years of treatment with oral conjugated estrogens (CE 0.625 mg) combined with medroxyprogesterone acetate (MPA 2.5 mg) relative to placebo. (See CLINICAL PHARMACOLOGY, Clinical Studies. )

The Women's Health Initiative Memory Study (WHIMS), a substudy of WHI, reported increased risk of developing probable dementia in postmenopausal women 65 years of age or older during 4 years of treatment with oral conjugated estrogens plus medroxyprogesterone acetate relative to placebo. It is unknown whether this finding applies to younger postmenopausal women or to women taking estrogen-alone therapy. (See CLINICAL PHARMACOLOGY, Clinical Studies .)

Other doses of conjugated estrogens with medroxyprogesterone acetate, and other combinations and dosage forms of estrogens and progestins were not studied in the WHI clinical trials and, in the absence of comparable data, these risks should be assumed to be similar. Because of these risks, estrogens with or without progestins should be prescribed at the lowest effective doses and for the shortest duration consistent with treatment goals and risks for the individual woman.

WHAT IS THE MOST IMPORTANT INFORMATION I SHOULD KNOW ABOUT DEPO-ESTRADIOL (AN ESTROGEN HORMONE)?

Estrogens increase the chances of getting cancer of the uterus.

Report any unusual vaginal bleeding right away while you are taking estrogens. Vaginal bleeding after menopause may be a warning sign of cancer of the uterine (womb). Your healthcare provider should check any unusual vaginal bleeding to find out the cause.

Do not use estrogens with or without progestins to prevent heart disease, heart attacks, or strokes.

Using estrogens with or without progestins may increase your chances of getting heart attacks, strokes, breast cancer, and blood clots. You and your healthcare provider should talk regularly about whether you still need treatment with DEPO-Estradiol.

INDICATIONS AND USAGE

DEPO-Estradiol Injection is indicated in the treatment of:

Moderate to severe vasomotor symptoms associated with the menopause.

Hypoestrogenism due to hypogonadism.

DOSAGE AND ADMINISTRATION

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration whenever solution and container permit.

Warming and shaking the vial should redissolve any crystals that may have formed during storage at temperatures lower than recommended.

DEPO-Estradiol INJECTION IS FOR INTRAMUSCULAR USE ONLY.

When estrogen is prescribed for a woman with a uterus, progestin should also be initiated to reduce the risk of endometrial cancer. A woman without a uterus does not need progestin. Use of estrogen, alone or in combination with a progestin, should be with the lowest effective dose and for the shortest duration consistent with treatment goals and risks for the individual woman. Patients should be reevaluated periodically as clinically appropriate (e. g. 3-month to 6-month intervals) to determine if treatment is still necessary. (See BOXED WARNINGS and WARNINGS .) For women who have a uterus, adequate diagnostic measures, such as endometrial sampling, when indicated, should be undertaken to rule out malignancy in cases of undiagnosed persistent or recurring abnormal vaginal bleeding.

Short-term cyclic use for treatment of moderate to severe vasomotor symptoms, vulval and vaginal atrophy associated with the menopause, the lowest dose and regimen that will control symptoms should be chosen and medication should be discontinued as promptly as possible.

Attempts to discontinue or taper medication should be made at 3- to 6-month intervals. The usual dosage range is 1 to 5 mg injected every 3 to 4 weeks.

For treatment of female hypoestrogenism due to hypogonadism 1.5 to 2 mg injected at monthly intervals.

CONTRAINDICATIONS

Estrogens should not be used in individuals with any of the following conditions:

Undiagnosed abnormal genital bleeding.

Known or suspected cancer of the breast.

Known or suspected estrogen-dependent neoplasia.

Active deep vein thrombosis, pulmonary embolism or history of these conditions.

Active or recent (e. g. within the past year) arterial thromboembolic disease (e. g. stroke, myocardial infarction).

Liver dysfunction or disease.

DEPO-Estradiol should not be used in patients with known hypersensitivity to its ingredients.

Known or suspected pregnancy. There is no indication for DEPO-Estradiol in pregnancy.

There appears to be little or no increased risk of birth defects in children born to women who have used estrogens and progestins from oral contraceptives inadvertently during early pregnancy. (See PRECAUTIONS .)

WARNINGS

1. Cardiovascular disorders

Estrogen and estrogen/progestin therapy have been associated with an increased risk of cardiovascular events such as myocardial infarction and stroke, as well as venous thrombosis and pulmonary embolism (venous thromboembolism or VTE). Should any of these occur or be suspected, estrogens should be discontinued immediately.

Risk factors for arterial vascular disease (e. g. hypertension, diabetes mellitus, tobacco use, hypercholesterolemia, and obesity) and/or venous thromboembolism (e. g. personal history or family history of VTE, obesity, and systemic lupus erythematosus) should be managed appropriately.

a. Coronary heart disease and stroke

In the Women's Health Initiative (WHI) study, an increase in the number of myocardial infarctions and strokes has been observed in women receiving CE compared to placebo. These observations are preliminary, and the study is continuing. (See CLINICAL PHARMACOLOGY, Clinical Studies .)

In the CE/MPA substudy of WHI, an increased risk of coronary heart disease (CHD) events (defined as nonfatal myocardial infarction and CHD death) was observed in women receiving CE/MPA compared to women receiving placebo (37 vs. 30 per 10,000 women-years). The increase in risk was observed in year one and persisted.

In the same substudy of WHI, an increased risk of stroke was observed in women receiving CE/MPA compared to women receiving placebo (29 vs. 21 per 10,000 women-years). The increase in risk was observed after the first year and persisted.

In postmenopausal women with documented heart disease (n = 2,763, average age 66.7 years) a controlled clinical trial of secondary prevention of cardiovascular disease (Heart and Estrogen/Progestin Replacement Study; HERS) treatment with CE/MPA (0.625 mg/2.5 mg per day) demonstrated no cardiovascular benefit. During an average follow-up of 4.1 years, treatment with CE/MPA did not reduce the overall rate of CHD events in postmenopausal women with established coronary heart disease. There were more CHD events in the CE/MPA-treated group than in the placebo group in year 1, but not during the subsequent years. Two thousand three hundred and twenty-one women from the original HERS trial agreed to participate in an open-label extension of HERS, HERS II. Average follow-up in HERS II was an additional 2.7 years, for a total of 6.8 years overall. Rates of CHD events were comparable among women in the CE/MPA group and the placebo group in HERS, HERS II, and overall.

Large doses of estrogen (5 mg conjugated estrogens per day), comparable to those used to treat cancer of the prostate and breast, have been shown in a large prospective clinical trial in men to increase the risks of nonfatal myocardial infarction, pulmonary embolism, and thrombophlebitis.

b. Venous thromboembolism (VTE)

In the Women's Health Initiative (WHI) study, in women receiving CE compared to placebo, the risk of VTE (including both DVT and PE) was increased 33% (28 vs. 21 per 10,000 person-years) although only the increased rate of DVT reached statistical significance (p = 0.03). (See CLINICAL PHARMACOLOGY, Clinical Studies .)

In the CE/MPA treatment substudy of WHI, a 2-fold greater rate of VTE, including deep venous thrombosis and pulmonary embolism, was observed in women receiving treatment with CE/MPA compared to women receiving placebo. The rate of VTE was 34 per 10,000 woman-years in the CE/MPA group compared to 16 per 10,000 woman-years in the placebo group. The increase in VTE risk was observed during the first year and persisted.

If feasible, estrogens should be discontinued at least 4 to 6 weeks before surgery of the type associated with an increased risk of thromboembolism, or during periods of prolonged immobilization.

2. Malignant neoplasms

a. Endometrial cancer

The use of unopposed estrogens in women with intact uteri has been associated with an increased risk of endometrial cancer. The reported endometrial cancer risk among unopposed estrogen users was about 2-to-12-fold greater than in non-users, and appears dependent on duration of treatment and on estrogen dose. Most studies show no significant increased risk associated with use of estrogens for less than one year. The greatest risk appears associated with prolonged use, with increased risks of 15-to-24-fold for five to ten years or more and this risk has been shown to persist for at least 8 to 15 years after estrogen therapy is discontinued.

Clinical surveillance of all women taking estrogen/progestin combinations is important. Adequate diagnostic measures, including endometrial sampling when indicated, should be undertaken to rule out malignancy in all cases of undiagnosed persistent or recurring abnormal vaginal bleeding. There is no evidence that the use of natural estrogens results in a different endometrial risk profile than synthetic estrogens of equivalent estrogen dose. Adding a progestin to estrogen therapy has been shown to reduce the risk of endometrial hyperplasia, which may be a precursor to endometrial cancer.

b. Breast cancer

The use of estrogens and progestins by postmenopausal women has been reported to increase the risk of breast cancer. The most important randomized clinical trial providing information about this issue is the Women's Health Initiative (WHI) substudy of CE/MPA (see CLINICAL PHARMACOLOGY, Clinical Studies ). The results from observational studies are generally consistent with those of the WHI clinical trial and report no significant variation in the risk of breast cancer among different estrogens or progestins, doses, or routes of administration.

The CE/MPA substudy of WHI reported an increased risk of breast cancer in women who took CE/MPA for a mean follow-up of 5.6 years. Observational studies have also reported an increased risk for estrogen/progestin combination therapy, and a smaller increased risk for estrogen-alone therapy, after several years of use. In the WHI trial and from observational studies, the excess risk increased with duration of use. From observational studies, the risk appeared to return to baseline in about five years after stopping treatment. In addition, observational studies suggest that the risk of breast cancer was greater, and became apparent earlier, with estrogen/progestin combination therapy as compared to estrogen-alone therapy.

In the CE/MPA substudy, 26% of the women reported prior use of estrogen-alone and/or estrogen/progestin combination hormone therapy. After a mean follow-up of 5.6 years during the clinical trial, the overall relative risk of invasive breast cancer was 1.24 (95% confidence interval 1.01–1.54), and the overall absolute risk was 41 vs. 33 cases per 10,000 women-years, for CE/MPA compared with placebo. Among women who reported prior use of hormone therapy, the relative risk of invasive breast cancer was 1.86, and the absolute risk was 46 vs. 25 cases per 10,000 women-years, for CE/MPA compared with placebo. Among women who reported no prior use of hormone therapy, the relative risk of invasive breast cancer was 1.09, and the absolute risk was 40 vs. 36 cases per 10,000 women-years for CE/MPA compared with placebo. In the same substudy, invasive breast cancers were larger and diagnosed at a more advanced stage in the CE/MPA group compared with the placebo group. Metastatic disease was rare with no apparent difference between the two groups. Other prognostic factors such as histologic subtype, grade and hormone receptor status did not differ between groups.

The use of estrogen plus progestin has been reported to result in an increase in abnormal mammograms requiring further evaluation. All women should receive yearly breast examinations by a healthcare provider and perform monthly breast self-examinations. In addition, mammography examinations should be scheduled based on patient age, risk factors, and prior mammogram results.

3. Dementia

In the Women's Health Initiative Memory Study (WHIMS), 4,532 generally healthy postmenopausal women 65 years of age and older were studied, of whom 35% were 70 to 74 years of age and 18% were 75 or older. After an average follow-up of 4 years, 40 women being treated with CE/MPA (1.8%, n= 2,229) and 21 women in the placebo group (0.9%, n= 2,303) received diagnoses of probable dementia. The relative risk for CE/MPA versus placebo was 2.05 (95% confidence interval 1.21 – 3.48), and was similar for women with and without histories of menopausal hormone use before WHIMS. The absolute risk of probable dementia for CE/MPA versus placebo was 45 versus 22 cases per 10,000 women-years. It is unknown whether these findings apply to younger postmenopausal women. (See CLINICAL PHARMACOLOGY, Clinical Studies and PRECAUTIONS, Geriatric Use .)

4. Gallbladder disease

A 2- to 4-fold increase in the risk of gallbladder disease requiring surgery in postmenopausal women receiving estrogen has been reported.

5. Hypercalcemia

Estrogen administration may lead to severe hypercalcemia in patients with breast cancer and bone metastases. If hypercalcemia occurs, use of the drug should be stopped and appropriate measures taken to reduce the serum calcium level.

6. Visual abnormalities

Retinal vascular thrombosis has been reported in patients receiving estrogens. Discontinue medication pending examination if there is sudden partial or complete loss of vision, or a sudden onset of proptosis, diplopia, or migraine. If examination reveals papilledema or retinal vascular lesions, estrogens should be permanently discontinued.

PRECAUTIONS

A. General

1. Addition of progestin when a woman has not had a hysterectomy

Studies of the addition of a progestin for 10 or more days of a cycle of estrogen administration, or daily with estrogen in a continuous regimen, have reported a lowered incidence of endometrial hyperplasia than would be induced by estrogen treatment alone. Endometrial hyperplasia may be a precursor to endometrial cancer.

There are, however, possible risks that may be associated with the use of progestins with estrogens compared to estrogen-alone regimens. These include a possible increased risk of breast cancer, adverse effects on lipoprotein metabolism (e. g. lowering HDL, raising LDL) and impairment of glucose tolerance.

2. Elevated blood pressure

In a small number of case reports, substantial increases in blood pressure have been attributed to idiosyncratic reactions to estrogens. In a large, randomized, placebo-controlled clinical trial, a generalized effect of estrogens on blood pressure was not seen. Blood pressure should be monitored at regular intervals with estrogen use.

3. Hypertriglyceridemia

In patients with pre-existing hypertriglyceridemia, estrogen therapy may be associated with elevations of plasma triglycerides leading to pancreatitis and other complications.

4. Impaired liver function and past history of cholestatic jaundice

Estrogens may be poorly metabolized in patients with impaired liver function. For patients with a history of cholestatic jaundice associated with past estrogen use or with pregnancy, caution should be exercised and in the case of recurrence, medication should be discontinued.

5. Hypothyroidism

Estrogen administration leads to increased thyroid-binding globulin (TBG) levels. Patients with normal thyroid function can compensate for the increased TBG by making more thyroid hormone, thus maintaining free T 4 and T 3 serum concentrations in the normal range. Patients dependent on thyroid hormone replacement therapy who are also receiving estrogens may require increased doses of their thyroid replacement therapy. These patients should have their thyroid function monitored in order to maintain their free thyroid hormone levels in an acceptable range.

6. Fluid retention

Because estrogens may cause some degree of fluid retention, patients with conditions that might be influenced by this factor, such as a cardiac or renal dysfunction, require careful observation when estrogens are prescribed.

7. Hypocalcemia

Estrogens should be used with caution in individuals with severe hypocalcemia.

8. Ovarian cancer

The CE/MPA substudy of WHI reported that estrogen plus progestin increased the risk of ovarian cancer. After an average follow-up of 5.6 years, the relative risk for ovarian cancer for CE/MPA versus placebo was 1.58 (95% confidence interval 0.77 – 3.24) but was not statistically significant. The absolute risk for CE/MPA versus placebo was 20 versus 12 cases per 10,000 women-years. In some epidemiologic studies, the use of estrogen alone, in particular for ten or more years, has been associated with an increased risk of ovarian cancer. Other epidemiologic studies have not found these associations.

9. Exacerbation of endometriosis

Endometriosis may be exacerbated with administration of estrogens. A few cases of malignant transformation of residual endometrial implants have been reported in women treated post-hysterectomy with estrogen-alone therapy. For patients known to have residual endometriosis post-hysterectomy, the addition of progestin should be considered.

10. Exacerbation of other conditions

Estrogens may cause an exacerbation of asthma, diabetes mellitus, epilepsy, migraine or porphyria, systemic lupus erythematosus, and hepatic hemangiomas and should be used with caution in women with these conditions.

B. PATIENT INFORMATION

Physicians are advised to discuss the PATIENT INFORMATION leaflet with patients for whom they prescribe DEPO-Estradiol.

C. LABORATORY TESTS

Estrogen administration should be initiated at the lowest dose for the approved indication and then guided by clinical response, rather than by serum hormone levels (e. g. estradiol, FSH).

D. DRUG/LABORATORY TEST INTERACTIONS

Accelerated prothrombin time, partial thromboplastin time, and platelet aggregation time; increased platelet count; increased factors II, VII antigen, VIII antigen, VIII coagulant activity, IX, X, XII, VII-X complex, II-VII-X complex, and beta-thromboglobulin; decreased levels of anti-factor Xa and antithrombin III, decreased antithrombin III activity; increased levels of fibrinogen and fibrinogen activity; increased plasminogen antigen and activity.

Increased thyroid-binding globulin (TBG) levels leading to increased circulating total thyroid hormone, as measured by protein-bound iodine (PBI), T4 levels (by column or by radioimmunoassay) or T3 levels by radioimmunoassay. T3 resin uptake is decreased, reflecting the elevated TBG. Free T4 and free T3 concentrations are unaltered. Patients on thyroid replacement therapy may require higher doses of thyroid hormone.

Other binding proteins may be elevated in serum, i. e. corticosteroid binding globulin (CBG), sex-hormone binding globulin (SHBG), leading to increased circulating corticosteroids and sex steroids, respectively. Free or biologically active hormone levels concentrations are unchanged. Other plasma proteins may be increased (angiotensinogen/renin substrate, alpha-1-anti-trypsin, ceruloplasmin).

Increased plasma HDL and HDL - 2 subfraction concentrations, reduced LDL cholesterol concentration, increased triglycerides levels.

Impaired glucose tolerance.

Reduced response to metyrapone test.

Reduced serum folate concentration.

E. CARCINOGENESIS, MUTAGENESIS, IMPAIRMENT OF FERTILITY

Long-term continuous administration of natural and synthetic estrogens in certain animal species increases the frequency of carcinomas of the breast, uterus, cervix, vagina, testis, and liver. (See BOXED WARINGS. WARNINGS and PRECAUTIONS .)

F. PREGNANCY

DEPO-Estradiol should not be used during pregnancy. See CONTRAINDICATIONS and Boxed WARNINGS.

G. NURSING MOTHERS

Estrogen administration to nursing mothers has been shown to decrease the quantity and quality of the milk. Detectable amounts of estrogens have been identified in the milk of mothers receiving this drug. Caution should be exercised when DEPO-Estradiol is administered to a nursing woman.

H. GERIATRIC USE

In the Women's Health Initiative Memory Study, including 4,532 women 65 years of age and older, followed for an average of 4 years, 82% (n= 3,729) were 65 to 74 while 18% (n= 803) were 75 and over. Most women (80%) had no prior hormone therapy use. Women treated with conjugated estrogens plus medroxyprogesterone acetate were reported to have a two-fold increase in the risk of developing probable dementia. Alzheimer's disease was the most common classification of probable dementia in both the conjugated estrogens plus medroxyprogesterone acetate group and the placebo group. Ninety percent of the cases of probable dementia occurred in the 54% of women that were older than 70. (See WARNINGS, Dementia .)

ADVERSE REACTIONS

The following additional adverse reactions have been reported with estrogens and/or progestin therapy.

1. Genitourinary system Changes in vaginal bleeding pattern and abnormal withdrawal bleeding or flow; breakthrough bleeding, spotting; dysmenorrhea; increase in size of uterine leiomyomata; vaginitis including vaginal candidiasis; change in amount of cervical secretion; changes in cervical ectropion; ovarian cancer; endometrial hyperplasia; endometrial cancer. 2. Breasts Tenderness, enlargement pain, nipple discharge, galactorrhea; fibrocystic breast changes; breast cancer. 3. Cardiovascular Deep and superficial venous thrombosis; pulmonary embolism; thrombophlebitis; myocardial infarction; stroke; increase in blood pressure. 4. Gastrointestinal Nausea, vomiting; abdominal cramps, bloating; cholestatic jaundice; increased incidence of gallbladder disease; pancreatitis, enlargement of hepatic hemangiomas. 5. Skin Chloasma or melasma that may persist when drug is discontinued. Erythema multiforme; erythema nodosum; hemorrhagic eruption; loss of scalp hair; hirsutism; pruritus, rash. 6. Eyes Retinal vascular thrombosis; steepening of corneal curvature; intolerance to contact lenses. 7. Central nervous system Headache, migraine, dizziness; mental depression; chorea; nervousness; mood disturbances; irritability; exacerbation of epilepsy, dementia. 8. Miscellaneous Increase or decrease in weight; reduced carbohydrate tolerance; aggravation of porphyria; edema; changes in libido; arthralgias; leg cramps; anaphylactoid/anaphylactic reactions including urticaria and angioedema; hypocalcemia; exacerbation of asthma; increased triglycerides.

DRUG ABUSE AND DEPENDENCE

OVERDOSAGE

DESCRIPTION

CLINICAL PHARMACOLOGY

For those outcomes included in the "global index," the absolute excess risks per 10,000 person-years in the group treated with CE/MPA were 7 more CHD events, 8 more strokes, 8 more PEs, and 8 more invasive breast cancers, while absolute risk reductions per 10,000 person-years were 6 fewer colorectal cancers and 5 fewer hip fractures. The absolute excess risk of events included in the "global index" was 19 per 10,000 women-years. There was no difference between the groups in terms of all-cause mortality. (See BOXED WARNINGS. WARNINGS and PRECAUTIONS. )

Women's Health Initiative Memory Study

The Women's Health Initiative Memory Study (WHIMS), a substudy of WHI, enrolled 4,532 predominantly healthy postmenopausal women 65 years of age and older (47% were age 65 to 69 years, 35% were 70 to 74 years, and 18% were 75 years of age and older) to evaluate the effects of CE/MPA (0.625 mg conjugated estrogens plus 2.5 mg medroxyprogesterone acetate) on the incidence of probable dementia (primary outcome) compared with placebo.

After an average follow-up of 4 years, 40 women in the estrogen/progestin group (45 per 10,000 women-years) and 21 in the placebo group (22 per 10,000 women-years) were diagnosed with probable dementia. The relative risk of probable dementia in the hormone therapy group was 2.05 (95% CI, 1.21 to 3.48) compared to placebo. Differences between groups became apparent in the first year of treatment. It is unknown whether these findings apply to younger postmenopausal women. (See BOXED WARNINGS and WARNINGS, Dementia. )

Comparative clinical studies have demonstrated that estradiol cypionate produces estrogenic effects that are qualitatively the same as those produced by other estradiol esters. In menopausal women, the average duration of estrogenic effect (as measured by vaginal smear) following a single injection of 5 mg of estradiol cypionate was found to be approximately 3 to 4 weeks. Relief of vasomotor symptoms was observed to occur within 1 to 5 days and to be maintained for 1 to 8 weeks, with an average of approximately 5 weeks.

REFERENCES

Ziel HK, Finkle WD: Increased risk of endometrial carcinoma among users of conjugated estrogens. N Engl J Med 293 :1167–1170, 1975.

Smith DC, Prentice R, Thompson DJ, et al: Association of exogenous estrogen and endometrial carcinoma. N Engl J Med 293 :1164–1167, 1975.

Mack TM, Pike MC, Henderson BE, et al: Estrogens and endometrial cancer in a retirement community. N Engl J Med 294 :1262–1267, 1976.

Weiss NS, Szekely DR, Austin DF: Increasing incidence of endometrial cancer in the United States. N Engl J Med 294 :1259–1262, 1976.

Herbst AL, Ulfelder H, Poskanzer DC: Adenocarcinoma of the vagina. Association of maternal stilbestrol therapy with tumor appearance in young women. N Engl J Med 284 :878–881, 1971.

Greenwald P, Barlow JJ, Nasca PC, Burnett WS: Vaginal cancer after maternal treatment with synthetic estrogens. N Engl J Med 285 :390–392, 1971.

Lanier AP, Noller KL, Decker DG, Elveback LR, Kurland LT: Cancer and stilbestrol. A follow-up of 1,719 persons exposed to estrogens in utero and born 1943–1959. Mayo Clin Proc 48 :793–799, 1973.

Herbst AL, Kurman RJ, Scully RE: Vaginal and cervical abnormalities after exposure to stilbestrol in utero. Obstet Gynecol 40 :287–298, 1972.

Herbst AL, Robboy SJ, Macdonald GJ, Scully RE: The effects of local progesterone on stilbestrol-associated vaginal adenosis. Am J Obstet Gynecol 118 :607–615, 1974.

Herbst AL, Poskanzer DC, Robboy SJ, Friedlander L, Scully RE: Prenatal exposure to stilbestrol. A prospective comparison of exposed female offspring with unexposed control. N Engl J Med 292 :334–339, 1975.

Stafl A, Mattingly RF, Foley DV, Fetherston WC: Clinical diagnosis of vaginal adenosis. Obstet Gynecol 43 :118–128, 1974.

Sherman AL, Goldrath M, Berlin A, et al: Cervical-vaginal adenosis after in utero exposure to synthetic estrogens. Obstet Gynecol 44 :531545, 1974.

Gall, Kirman B, Stern J: Hormonal pregnancy tests and congenital malformation. Nature 216 :83, 1967.

Levy EP, Cohen A, Fraser FC: Hormone treatment during pregnancy and congenital heart defects. Lancet 1 :611, 1973.

Nora JJ, Nora AH: Birth defects and oral contraceptives. Lancet 1 :941–942, 1973.

Janerich DT, Piper JM, Glebatis DM: Oral contraceptives and congenital limb-reduction defects. N Engl J Med 291 :697–700, 1974.

Boston Collaborative Drug Surveillance Program: Surgically confirmed gall bladder disease, venous thromboembolism, and breast tumors in relation to post-menopausal estrogen therapy. N Engl J Med 290 :15–19, 1974.

Hoover R, Gray LA, Cole P, MacMahon B: Menopausal estrogens and breast cancer. N Engl J Med 295 :401–405, 1976.

Boston Collaborative Drug Surveillance Program: Oral contraceptives and venous thromboembolic disease, surgically confirmed gall bladder disease, and breast tumors. Lancet 1 :1399–1404, 1973.

Daniel DG, Campbell H, Turnbull AC: Puerperal thromboembolism and suppression of lactation. Lancet 2 :287–289, 1967.

The Veterans Administration Cooperative Urological Research Group: Carcinoma of the prostate: Treatment comparisons. J Urol 98 :516522, 1967.

Bailar JC: Thromboembolism and estrogen therapy. Lancet 2 :560, 1967.

Blackard CE, Doe RP, Mellinger GT, Byar DP: Incidence of cardiovascular disease and death in patients receiving diethylstilbestrol for carcinoma of the prostate. Cancer 26 :249–256, 1970.

Royal College of General Practitioners: Oral contraception and thromboembolic disease. J R Coll Gen Pract 13 :267–279, 1967.

Inman WHW, Vessey MP: Investigation of deaths from pulmonary, coronary, and cerebral thrombosis and embolism in women of childbearing age. Br Med J 2 :193–199, 1968.

Vessey MP, Doll R: Investigation of relation between use of oral contraceptives and thromboembolic disease. A further report. Br Med J 2 :651–657, 1969.

Sartwell PE, Masi AT, Arthes FG, et al: Thromboembolism and oral contraceptives: An epidemiologic case-control study. Am J Epidemiol 90 :365–380, 1969.

Collaborative Group for the Study of Stroke in Young Women: Oral contraception and increased risk of cerebral ischemia or thrombosis. N Engl J Med 288 :871–878, 1973.

Collaborative Group for the Study of Stroke in Young Women: Oral contraceptives and stroke in young women: Associated risk factors. JAMA 231 :718–722, 1975.

Mann JI, Inman WHW: Oral contraceptives and death from myocardial infarction. Br Med J 2 :245–248, 1975.

Mann JI, Vessey MP, Thorogood M, Doll R: Myocardial infarction in young women with special reference to oral contraceptive practice. Br Med J 2 :241–245, 1975.

Inman WHW, Vessey MP, Westerholm B, Engelund A: Thromboembolic disease and the steroidal content of oral contraceptives. Br Med J 2 :203–209, 1970.

Stolley PD, Tonascia JA, Tockman MS, et al: Thrombosis with low-estrogen oral contraceptives. Am J Epidemiol 102 :197–208, 1975.

Vessey MP, Doll R, Fairbairn AS, Glober G: Postoperative thromboembolism and the use of oral contraceptives. Br Med J 3 :123–126, 1970.

Greene GR, Sartwell PE: Oral contraceptive use in patients with thromboembolism following surgery, trauma or infection. Am J Public Health 62 :680–685, 1972.

Rosenberg L, Armstrong B, Phil D, Jick H: Myocardial infarction and estrogen therapy in post-menopausal women. N Engl J Med 294 :1256–1259, 1976.

Coronary Drug Project Research Group: The Coronary Drug Project: Initial findings leading to modifications of its research protocol. JAMA 214 :1303–1313, 1970.

Baum J, Holtz F, Bookstein JJ, Klein EW: Possible association between benign hepatomas and oral contraceptives. Lancet 2 :926–929, 1973.

Mays ET, Christopherson WM, Mahr MM, Williams HC: Hepatic changes in young women ingesting contraceptive steroids. Hepatic hemorrhage and primary hepatic tumors. JAMA 235 :730–732, 1976.

Edmondson HA, Henderson B, Benton B: Liver-cell adenomas associated with use of oral contraceptives. N Engl J Med 294 :470–472, 1976.

Pfeffer RI, VanDenNoort S: Estrogen use and stroke risk in post-menopausal women. Am J Epidemiol 103 :445–456, 1976.

HOW SUPPLIED

DEPO-Estradiol Injection is available in the following concentration containing per mL:

5 mg estradiol cypionate; also 5.4 mg chlorobutanol anhydrous (chloral deriv.) added as preservative; in 913 mg cottonseed oil — in 5 mL vials, NDC 0009-0271-01.

WARNING: Chlorobutanol may be habit forming.

Store at controlled room temperature 20° to 25° C (68° to 77° F) [see USP].

PATIENT INFORMATION

Brand of estradiol cypionate injection, USP

Read this PATIENT INFORMATION before you start taking DEPO-Estradiol and read what you get each time you refill DEPO-Estradiol. There may be new information. This information does not take the place of talking to your healthcare provider about your medical condition or your treatment.

The text of the patient insert for estrogen-containing drug products is set forth below.

What is DEPO-Estradiol?

Depo-Estradiol injection is an estrogen product. The information below is that which the U. S. Food and Drug Administration requires be provided for all patients taking estrogens. For further information ask your doctor.

What is DEPO-Estradiol used for?

DEPO-Estradiol is used during and after menopause to:

reduce moderate or severe menopausal symptoms. Estrogens are hormones made by a woman's ovaries. The ovaries normally stop making estrogens when a woman is between 45 to 55 years old. This drop in body estrogen levels causes the "change of life" or menopause (end of monthly menstrual periods). Sometimes both ovaries are removed during an operation before natural menopause takes place, the sudden drop in estrogen levels causes "surgical menopause."

When the estrogen levels begin dropping, some women develop very uncomfortable symptoms, such as feeling of warmth in the face, neck and chest or sudden strong feelings of heat and sweating ("hot flashes" or "hot flushes"). Using estrogen drugs can help the body adjust to lower estrogen levels and reduce these symptoms. Most women have only mild menopause symptoms or none at all and do not need estrogen drugs for these symptoms.

treat moderate to severe itching, burning, and dryness in or around the vagina. You and your healthcare provider should talk regularly about whether you still need treatment with DEPO-Estradiol to control these problems.

DEPO-Estradiol is also used to:

treat certain conditions in women before menopause if their ovaries do not make enough estrogen.

Who should not take DEPO-Estradiol?

Do not start taking DEPO-Estradiol if you:

have unusual vaginal bleeding.

currently have or have had certain cancers. Estrogens may increase the chances of getting certain types of cancers, including cancer of the breast or uterus. If you have or had cancer, talk with your healthcare provider about whether you should take DEPO-Estradiol.

had a stroke or heart attack in the past year.

currently have or have had blood clots.

are allergic to DEPO-Estradiol or any of its ingredients.

See the end of this leaflet for a list of ingredients in DEPO-Estradiol.

think you may be pregnant.

Tell your healthcare provider:

if you are breastfeeding.

The hormone in DEPO-Estradiol can pass into your milk.

about all of your medical problems. Your healthcare provider may need to check you more carefully if you have certain conditions, such as asthma (wheezing), epilepsy (seizures), migraine, endometriosis, or problems with your heart, liver, thyroid, kidneys, or have high calcium levels in your blood.

about all the medicines you take. This includes prescription and nonprescription medicines, vitamins, and herbal supplements. Some medicines may affect how DEPO-ESTRADIOL works. DEPO-ESTRADIOL may also affect how your other medicines work.

if you are going to have surgery or will be on bed rest. You may need to stop taking estrogens.

How should I take DEPO-Estradiol?

Take DEPO-Estradiol as directed by your healthcare provider.

Estrogens should be used only as long as needed. You and your healthcare provider should talk regularly (for example, every 3 to 6 months) about whether you still need treatment with DEPO-ESTRADIOL.

What are the possible side effects of estrogens?

Less common but serious side effects include:

Breast cancer

Cancer of the uterus

Stroke

Heart attack

Blood clots

Gallbladder disease

Ovarian cancer

These are some of the warning signs of serious side effects:

Breast lumps

Unusual vaginal bleeding

Dizziness and faintness

Changes in speech

Severe headaches

Chest pain

Shortness of breath

Pains in your legs

Changes in vision

Vomiting

Call your healthcare provider right away if you get any of these warning signs, or any other unusual symptom that concerns you.

Common side effects include:

Headache

Breast pain

Irregular vaginal bleeding or spotting

Stomach/abdominal cramps, bloating

Nausea and vomiting

Other side effects include:

High blood pressure

Liver problems

High blood sugar

Fluid retention

Enlargement of benign tumors of the uterus ("fibroids")

Vaginal yeast infections

Hair loss

These are not all the possible side effects of DEPO-Estradiol. For more information, ask your healthcare provider or pharmacist.

What can I do to lower my chances of getting a serious side effect with DEPO-Estradiol?

Talk with your healthcare provider regularly about whether you should continue taking DEPO-ESTRADIOL. If you have a uterus, talk to your healthcare provider about whether the addition of a progestin is right for you. See your healthcare provider right away if you get vaginal bleeding while taking DEPO-ESTRADIOL. Have a breast exam and mammogram (breast X-ray) every year unless your healthcare provider tells you something else. If members of your family have had breast cancer or if you have ever had breast lumps or an abnormal mammogram, you may need to have breast examinations more often. If you have high blood pressure, high cholesterol (fat in the blood), diabetes, are overweight, or if you use tobacco, you may have higher chances for getting heart disease. Ask your healthcare provider for ways to lower your chances for getting heart disease.

General information about safe and effective use of DEPO-Estradiol

Medicines are sometimes prescribed for conditions that are not mentioned in patient information leaflets. Do not take DEPO-Estradiol for conditions for which it was not prescribed. Do not give DEPO-Estradiol to other people, even if they have the same symptoms you have. It may harm them. Keep DEPO-Estradiol out of the reach of children.

This leaflet provides a summary of the most important information about DEPO-Estradiol. If you would like more information, talk with your healthcare provider or pharmacist. You can ask for information about DEPO-Estradiol that is written for health professionals. You can get more information by calling the toll free number 1-888-691-6813. You are cautioned to discuss very carefully with your doctor or healthcare provider all the possible risks and benefits of long-term estrogen and progestin treatment as they affect you personally.

Helpful Links for Consumers

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For all other inquiries, click here .

Important Notice

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Anabolic Steroids Sa Betasleep And Clen (1, Betasleep

TOPIC: Betasleep and clen

Anyways for those of you who are intersted, Im am definately sure now that betasleep keeps the beta receptors up far more than 1mg of ketotifen when cycling clenbuterol. I still experience shakes at 50 mcg of clen when cycled 2 days on and 2 days off and this has been occurring for over a month now. At 50mcg clen on ketotifen the shakes were only around for three days or so and disappeared even when i bumped it up to 80mcg.

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Betasleep and clen 19 Mar 2010 11:35 #40305

Oh cool, I would imagine you get Betasleep from the Pharmacy OTC? How much ydo you take per day?

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Betasleep and clen 19 Mar 2010 11:35 #40306

if using beta sleep why are u cycling the clen, u can use it daily with the beta sleep.

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Betasleep and clen 19 Mar 2010 11:39 #40307

Im cycling the clen because Im alternating between heat and clen. Yeah you can get it at the pharmacy and its OTC. I take two caps at night

Rosuvastatin Oral Uses, Side Effects, Interactions, Pictures, Warnings - Dosing, Rosuvastatine

rosuvastatin

GENERIC NAME(S): ROSUVASTATIN CALCIUM

Uses

Rosuvastatin is used along with a proper diet to help lower "bad" cholesterol and fats (such as LDL. triglycerides ) and raise "good" cholesterol (HDL) in the blood. It belongs to a group of drugs known as "statins ." It works by reducing the amount of cholesterol made by the liver. Lowering "bad" cholesterol and triglycerides and raising "good" cholesterol decreases the risk of heart disease and helps to prevent strokes and heart attacks .

In addition to eating a proper diet (such as a low cholesterol/low-fat diet), other lifestyle changes that may help this medication work better include exercising. losing weight if overweight. and stopping smoking. Talk with your doctor for more details.

How to use rosuvastatin

Read the Patient Information Leaflet if available from your pharmacist before you start taking rosuvastatin and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth with or without food as directed by your doctor, usually once daily.

The dosage is based on your medical condition, response to treatment, age, race, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). If you are of Asian descent, your doctor may direct you to start with a lower dose because you may be more sensitive to its effects.

Antacids containing aluminum or magnesium can reduce the absorption of this drug. Therefore, if taking this type of antacid, take it at least 2 hours after this medication.

Take this medication regularly in order to get the most benefit from it. Remember to take it at the same time each day. It is important to continue taking this medication even if you feel well. Most people with high cholesterol or triglycerides do not feel sick.

It is very important to continue to follow your doctor's advice about diet and exercise. It may take up to 4 weeks before you get the full benefit of this drug.

Side Effects

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A very small number of people taking rosuvastatin may have mild memory problems or confusion. If these rare effects occur, talk to your doctor.

Rarely, statins may cause or worsen diabetes. Talk to your doctor about the benefits and risks.

Tell your doctor right away if this unlikely but serious side effect occurs: foamy urine.

This drug may rarely cause muscle problems (which can rarely lead to very serious conditions called rhabdomyolysis and autoimmune myopathy). Tell your doctor right away if you develop any of these symptoms during treatment and if these symptoms persist after your doctor stops this drug: muscle pain /tenderness/weakness (especially with fever or unusual tiredness), signs of kidney problems (such as change in the amount of urine).

This medication may rarely cause liver problems. If you notice any of the following rare but serious side effects, tell your doctor right away: yellowing eyes /skin. dark urine, severe stomach /abdominal pain. persistent nausea /vomiting .

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction. including: rash. itching /swelling (especially of the face/tongue /throat), dizziness. trouble breathing .

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking rosuvastatin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease. alcohol use.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Limit alcoholic beverages. Daily use of alcohol may increase your risk for liver problems, especially when combined with rosuvastatin. Ask your doctor or pharmacist for more information.

Older adults may be more sensitive to the side effects of this drug, especially muscle problems.

This medication must not be used during pregnancy. Rosuvastatin may harm an unborn baby. Therefore, it is important to prevent pregnancy while taking this medication. Consult your doctor for more details and to discuss the use of reliable forms of birth control (such as condoms. birth control pills ) while taking this medication. If you become pregnant or think you may be pregnant, tell your doctor right away.

It is unknown if this medication passes into breast milk. Because of the possible risk to the infant. breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.

Interactions

See also How to Use section.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: "blood thinners" (such as warfarin), gemfibrozil.

Other medications can affect the removal of rosuvastatin from your body, which may affect how rosuvastatin works. Examples include ledipasvir, among others.

Do not take any red yeast rice products while you are taking rosuvastatin because some red yeast rice products may also contain a statin called lovastatin. Taking rosuvastatin and red yeast rice products together can increase your risk of serious muscle and liver problems.

Overdose

If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Notes

Do not share this medication with others.

Laboratory and/or medical tests (such as blood cholesterol/triglyceride levels) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose (within 12 hours), skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Information last revised April 2016. Copyright(c) 2016 First Databank, Inc.

Images

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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Buy Klarmyn - Clarithromycin - Online Without Prescriptions, Klarmyn

Biaxin (Klarmyn)

Biaxin is used for treating infections caused by certain bacteria. Biaxin is a macrolide antibiotic. It works by stopping the growth of or killing sensitive bacteria by reducing the production of important proteins needed by the bacteria to survive.

Use Biaxin as directed by your doctor.

Take Biaxin by mouth with or without food.

Biaxin works best if it is taken at the same time each day.

Continue to take Biaxin even if you feel well.

Do not miss any dose. If you miss a dose of Biaxin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Biaxin.

Store Biaxin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Biaxin out of the reach of children and away from pets.

Active Ingredient: Clarithromycin.

Do NOT use Biaxin if:

you are allergic to any ingredient in Biaxin or to any other macrolide (eg, erythromycin)

you are taking cisapride, cyclosporine, dofetilide, eletriptan, an ergot alkaloid (eg, dihydroergotamine, ergotamine), an H 1 antagonist (eg, astemizole, terfenadine), pimozide, a QT-prolonging agent (eg, quinidine, sotalol, thioridazine), a quinolone (eg, ciprofloxacin), or sumatriptan.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Biaxin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have diarrhea, a stomach infection, a blood disorder, severe kidney problems, or liver problems.

Some medicines may interact with Biaxin. Tell your health care provider if you are taking any other medicines, especially any of the following:

Aldosterone blockers (eg, spironolactone), anticoagulants (eg, warfarin), benzodiazepines (eg, alprazolam), buspirone, carbamazepine, cilostazol, cisapride, colchicine, corticosteroids (eg, hydrocortisone), cyclosporine, digoxin, disopyramide, eletriptan, ergot alkaloids (eg, ergotamine, dihydroergotamine), H 1 antagonists (eg, astemizole, terfenadine), HMG-CoA reductase inhibitors (eg, simvastatin), imatinib, macrolide immunosuppressants (eg, tacrolimus), macrolides and ketolides (eg, azithromycin, erythromycin), phosphodiesterase type 5 inhibitors (eg, sildenafil), rifampin, sumatriptan, theophyllines, or verapamil because their actions and the risk of their side effects may be increased by Biaxin

Dofetilide, macrolides and ketolides (eg, azithromycin, erythromycin), pimozide, QT-prolonging agents (eg, quinidine, sotalol, thioridazine), quinolones (eg, ciprofloxacin), or streptogramins (eg, mikamycin) because serious, possibly life-threatening side effects on the heart or irregular heartbeat may occur

Rifampin because it may decrease Biaxin's effectiveness.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Biaxin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Biaxin only works against bacteria; it does not treat viral infections (eg, the common cold).

Long-term or repeated use of Biaxin may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.

Be sure to use Biaxin for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.

Mild diarrhea is common with antibiotic use. However, a more serious form of diarrhea (pseudomembranous colitis) may rarely occur. This may develop while you use the antibiotic or within several months after you stop using it. Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.

Lab tests, including complete blood cell counts, may be performed while you use Biaxin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Biaxin should not be used in children younger 6 months; safety and effectiveness in these children have not been confirmed.

Pregnancy and breast-feeding: Biaxin has been shown to cause harm to the fetus. Biaxin is not recommended for use during pregnancy except when no other antibiotics can be used. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Biaxin while you are pregnant. It is not known if Biaxin is found in breast milk. If you are or will be breast-feeding while you use Biaxin, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Abnormal taste; diarrhea; headache; indigestion; nausea; stomach discomfort; vomiting.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody stools; confusion; decreased urination; depression; emotional or mood changes; hallucinations; nightmares; severe diarrhea; severe stomach pain/cramps; trouble sleeping.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Propecia (Zasterid)

Propecia is used for treating certain types of male pattern hair loss (androgenic alopecia) in men. Propecia is a steroid reductase inhibitor. It works by reducing the amount of the hormone dihydrotestosterone (DHT) in the body. This may block certain types of hair loss in men.

Use Propecia as directed by your doctor.

Take Propecia by mouth with or without food.

Continue to take Propecia even if you notice improvement of your symptoms. Do not miss any dose.

Taking Propecia at the same time each day will help your remember to take it.

If you miss a dose of Propecia, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Propecia.

Store Propecia at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Propecia out of the reach of children and away from pets.

Active Ingredient: Finasteride.

Inactive Ingredients: lactose monohydrate, microcrystalline cellulose, pregelatinized starch, sodium starch glycolate, hydroxypropyl methylcellulose, hydroxypropyl cellulose LF, titanium dioxide, magnesium stearate, talc, docusate sodium, yellow ferric oxide, and red ferric oxide.

Propecia can affect a blood test called PSA (Prostate-Specific Antigen) for the screening of prostate cancer. If you have a PSA test done, you should tell your doctor(s) that you are taking Propecia. Because Propecia decreases PSA levels, changes in PSA levels will need to be carefully evaluated by your doctor(s). Any increase in follow-up PSA levels from their lowest point should be carefully evaluated even if the test results are still within the normal range for men not taking Propecia. You should also tell your doctor if you have not been taking Propecia as prescribed because this may affect the PSA test results. For more information, talk to your doctor.

Do NOT use Propecia if:

you are allergic to any ingredient in Propecia

the patient is a woman or a child.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Propecia. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a narrowing or blockage in the urinary tract, prostate cancer, or trouble urinating

if you have a history of abnormal liver function tests or liver problems.

Some medicines may interact with Propecia. However, no specific interactions with Propecia are known at this time. Ask your health care provider if Propecia may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

You may need to take Propecia for up to 3 months before you notice any improvement. Do not take more than the recommended dose without checking with your doctor.

If your symptoms do not improve within 12 months, check with your doctor. You may need to discuss other treatment options.

Infrequently, Propecia may cause decreased sexual desire or ability. These effects usually decrease in men who continue to take Propecia. If they continue or become bothersome, check with your doctor.

Propecia may increase the risk of certain birth defects, including abnormal formation of genitalia in male fetuses. Propecia is coated to prevent contact with finasteride while handling undamaged tablets. The coating is not effective if the tablets are damaged, broken, or crushed. Women who are pregnant or may be pregnant should avoid contact with damaged, broken, or crushed tablets. If contact occurs, tell your doctor at once.

Propecia may interfere with certain lab tests, including prostate-specific antigen tests. Be sure your doctor and lab personnel know you are taking Propecia.

Propecia is for use by men only and should not be used by women or children.

All medicines may cause side effects, but many people have no, or minor, side effects.

No common side effects have been reported with Propecia.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); breast enlargement, lumps, pain, or tenderness; nipple discharge; testicular pain.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Your order will be packed safely and secure and dispatched within 24 hours. This is how your parcel will look like, the images are photographs of real shipments. It has the size of a normal protected envelope and it does not disclose its contents.

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