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Lupimox Forte Capsule - Uses, Side-Effects, Reviews, Composition, Interactions, Precautions, Substit

Lupimox Forte Capsule

Lupimox Forte Capsule - Uses, Composition, Side Effects and Reviews

Lupimox Forte Capsule is indicated for the treatment of bacterial infections of urinary tract, bacterial infections of respiratory tract, bacterial infections of skin, bacterial infections of heart, bacterial infections of gums, bacterial infections of ear and other conditions. Lupimox Forte Capsule contains the following active ingredients: Amoxycillin, Dicloxacillin. It is available in capsule form. Lupin manufactures Lupimox Forte Capsule. Detailed information related to Lupimox Forte Capsule's uses, composition, dosage, side effects and reviews is listed below:

Lupimox Forte Capsule Uses

Lupimox Forte Capsule is used in the treatment, control, prevention, & improvement of the following diseases, conditions and symptoms:

Bacterial infections of urinary tract

Bacterial infections of respiratory tract

Bacterial infections of skin

Bacterial infections of heart

Bacterial infections of gums

Bacterial infections of ear

Bacterial infections

Learn more: Uses (in more detail)

Lupimox Forte Capsule Working, Mechanism of Action and Pharmacology

Lupimox Forte Capsule improves the patient's condition by performing the following functions:

Lupimox Forte Capsule Composition and Active Ingredients

Lupimox Forte Capsule is composed of the following active ingredients (salts)

Please note that this medicine may be available in various strengths for each active ingredient listed above.

Lupimox Forte Capsule Side-effects

The following is a list of possible side effects that may occur from all constituting ingredients of Lupimox Forte Capsule. This is not a comprehensive list. These side effects are possible, but do not always occur. Some of the side effects may be rare but serious. Consult your doctor if you observe any of the following side effects, especially if they do not go away.

Nausea

Skin rash

Severe skin allergies

Pain

Irritation at the site of injection

Vomiting

If you notice other side effects not listed above, contact your doctor for medical advice. You may also report side effects to your local food and drug administration authority.

Learn more: Side-effects (in more detail)

Lupimox Forte Capsule Precautions & How to Use

Before using this drug, inform your doctor about your current list of medications, over the counter products (e. g. vitamins, herbal supplements, etc.), allergies, pre-existing diseases, and current health conditions (e. g. pregnancy, upcoming surgery, etc.). Some health conditions may make you more susceptible to the side effects of the drug. Take as directed by your doctor or follow the direction printed on the product insert. Dosage is based on your condition. Tell your doctor if your condition persists or worsens. Important counseling points are listed below.

Birth control pills may not work

Do not take it for more than 2 weeks

Do periodic assessment of renal, hepatic or hematopoietic functions

Keep taking medicine until treatment is finished

Space the doses evenly during the day

Take by mouth either 1 hour before or 2 hours after eating

Learn more: Precautions & How to Use (in more detail)

Lupimox Forte Capsule Frequently asked Questions

Can Lupimox Forte Capsule be used for Bacterial infections of urinary tract and Bacterial infections of respiratory tract?

Yes, bacterial infections of urinary tract and bacterial infections of respiratory tract are among the most common reported uses for Lupimox Forte Capsule. Please do not use Lupimox Forte Capsule for bacterial infections of urinary tract and bacterial infections of respiratory tract without consulting first with your doctor. Click here to find out what other patients report as common uses for Lupimox Forte Capsule.

Should I consume Lupimox Forte Capsule empty stomach, before food or after food?

TabletWise. com website users have most commonly reported consuming Lupimox Forte Capsule after food. However, this may not be reflective of how you should consume this medicine. Please follow your doctor's advice on how you should eat this medicine. Click here to find out what other patients report as timing of using Lupimox Forte Capsule.

Is it safe to drive or operate heavy machinery when consuming?

If you experience drowsiness, dizziness, hypotension or headache as side-effects when eating Lupimox Forte Capsule medicine then it maybe not be safe to drive a vehicle or operate heavy machinery. One should not drive a vehicle if eating the medicine makes you drowsy, dizzy or lowers your blood-pressure extensively. Pharmacists also advise patients not to drink alcohol with medicines as alcohol intensifies drowsiness side-effects. Please check for these effects on your body when using Lupimox Forte Capsule. Always consult with your doctor for recommendations specific to your body and health conditions.

Is this medicine or product addictive or habit forming?

Most medicines don't come with a potential for addiction or abuse. Usually, government's categorizes medicines that can be addictive as controlled substances. Examples include schedule H or X in India and schedule II-V in the US. Please consult the product package to make sure that the medicine does not belong to such special categorizations of medicines. Lastly, do not self-medicate and increase your body's dependence to medicines without the advice of a doctor.

Can it be stopped immediately or do I have to slowly ween off consumption?

Some medicines need to be tapered or cannot be stopped immediately because of rebound effects. Please consult with your doctor for recommendations specific to your body, health and other medications that you may be using.

Is Lupimox Forte Capsule safe to consume or apply when pregnant?

Please consult with your doctor for case-specific recommendations.

Is Lupimox Forte Capsule safe while breastfeeding?

Please discuss the risks and benefits with your doctor.

Consumer Survey: Lupimox Forte Capsule

The following are the results of on-going survey on TabletWise. com for Lupimox Forte Capsule. These results only indicate the perceptions of the website users. Please base your medical decisions only on the advice of a doctor or a registered medical professional.

Uses, Effectiveness and Side-effects

Following are the uses, perceived effectiveness and perceived side-effects incidence information reported by website visitor for Lupimox Forte Capsule:

User reported uses

The most common reported use for this medicine is bacterial infections of urinary tract.

Lupimox Forte Capsule Drug Interactions

If you take other drugs or over the counter products at the same time, the effects of Lupimox Forte Capsule may change. This may increase your risk for side effects or cause your drug not to work properly. Tell your doctor about all the drugs, vitamins, and herbal supplements you are using, so that you doctor can help you prevent or manage drug interactions. Lupimox Forte Capsule may interact with the following drugs and products:

Learn more: Interactions (in more detail)

Lupimox Forte Capsule Contraindications

Hypersensitivity to Lupimox Forte Capsule is a contraindication. In addition, Lupimox Forte Capsule should not be taken if you have the following conditions:

Learn more: Contraindications (in more detail)

Other important Information on Lupimox Forte Capsule

Missing a dose

In case you miss a dose, take it as soon as you notice. If it is close to the time of your next dose, skip the missed dose and resume your dosing schedule. Do not take extra dose to make up for a missed dose. If you are regularly missing doses, consider setting an alarm or asking a family member to remind you. Please consult your doctor to discuss changes in your dosing schedule or a new schedule to make up for missed doses, if you have missed too many doses recently.

Overdosage of Lupimox Forte Capsule

Do not take more than prescribed dose. Taking more medication will not improve your symptoms; rather they may cause poisoning or serious side effects. If you suspect that you or anyone else who may have overdosed of Lupimox Forte Capsule, please go to the emergency department of the closest hospital or nursing home. Bring a medicine box, container, or label with you to help doctors with necessary information.

Do not give your medicines to other people even if you know that they have the same condition or it seems that they may have similar conditions. This may lead to overdosage.

Please consult your physician or pharmacist or product package for more information.

Storage of Lupimox Forte Capsule

Store medicines at room temperature, away from heat and direct light. Do not freeze medicines unless required by package insert. Keep medicines away from children and pets.

Do not flush medications down the toilet or pour them into drainage unless instructed to do so. Medication discarded in this manner may contaminate the environment. Please consult your pharmacist or doctor for more details on how to safely discard Lupimox Forte Capsule.

Expired Lupimox Forte Capsule

Taking a single dose of expired Lupimox Forte Capsule is unlikely to produce an adverse event. However, please discuss with your primary health provider or pharmacist for proper advice or if you feel unwell or sick. Expired drug may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to take expired drug. If you have a chronic illness that requires taking medicine constantly such as heart condition, seizures, and life-threatening allergies, you are much safer keeping in touch with your primary health care provider so that you can have a fresh supply of unexpired medications.

Dosage Information

Please consult your physician or pharmacist or refer to product package.

Lupimox Forte Capsule Packages and Strengths

Lupimox Forte Capsule is available in the following packages and strengths

Lupimox Forte Capsule Packages: 10 Capsule

Lupimox Forte Capsule Strengths: 250+250, 250MG+250MG

Lupimox Forte Capsule Manufacturers



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Do NOT use Chloramphenicol if:

you are allergic to any ingredient in Chloramphenicol

you have previously had serious side effects from Chloramphenicol

you have a low white or red blood cell count or decreased blood platelets

you have a minor infection such as a cold, flu, throat infection, or you are using Chloramphenicol to prevent a bacterial infection

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How to enable 'Hey, Cortana' on Windows 10

@MrCippy

July 30, 2015 9:10 AM PDT Updated: July 30, 2015 12:14 PM PDT

Editors' note: This post has been updated to reflect changes to Windows 10 and the process for activating "Hey, Cortana."

One of the standout new features found in Windows 10 is the addition of Cortana. For those unfamiliar, Cortana is a voice-activated personal assistant. Think of it as Siri, but for Windows. You can use it to get weather forecasts, set reminders, tell you jokes. send email, find files, search the Internet and so on.

One feature aimed at making Cortana a staple of your Windows 10 experience involves being able to summon the digital assistant using nothing but your voice with a simple "Hey, Cortana" command. The only thing is, at least as of right now in the technical preview, you have to enable this feature.

You can now go about using your computer as you normally would, and whenever you need Cortana to perform a task, start by saying, "Hey, Cortana," followed by your command. I've found you have to continue with your command immediately after the activation prompt, instead of waiting for Cortana to load and indicate that it's listening.

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Vagimycin is Ampoterecin Tetracycline and it is packaged in a gold foil.

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Ciprofloxacin is an antibacterial medication designed mainly for treating a variety of infection, such as urinary tract infection, skin infection, and diseases that are susceptible of bacteria. I took ciprofloxacin hydrochloride in 500mg many times in my life, which doctors prescribed for my skin infection and vaginal infection. First.

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The review was published as it's written by reviewer in August, 2010. The reviewer certified that no compensation was received from the reviewed item producer, trademark owner or any other institution, related with the item reviewed. The site is not responsible for the mistakes made. 2616081233990831/k2311a0816/8.16.10

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Biofloxin, Biofloxin

Ciplox is used to treat different types of bacterial infections. It may also be used to prevent or slow anthrax after exposure.

Take Cipro exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Take Cipro with a full glass of water (8 ounces). Drink several extra glasses of fluid each day while you are taking this medicine. Cipro may be taken with or without food, but take it at the same time each day. Shake the oral suspension (liquid) for at least 15 seconds just before you measure a dose. To be sure you get the correct dose, measure the liquid with a marked measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

When taking the Cipro oral liquid, swallow it without chewing the medicine beads you may notice in the liquid.

Do not crush, chew, or break an extended-release tablet. Swallow it whole. Breaking the pill may cause too much of the drug to be released at one time. Do not take Cipro with dairy products such as milk or yogurt, or with calcium-fortified juice. You may eat or drink these products as part of a regular meal, but do not use them alone when taking Cipro. They could make the medication less effective.

Take Cipro for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Cipro will not treat a viral infection such as the common cold or flu.

Store Cipro at room temperature away from moisture and heat. Do not allow the liquid medicine to freeze.

If you missed a dose - take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Take exactly as prescribed by your Health Provider.

Store this medicine at room temperature away from moisture and heat. Do not allow the liquid medicine to freeze.

You should not use Ciplox if you are taking tizanidine (Zanaflex), if you have a history of myasthenia gravis, or if you are allergic to ciprofloxacin or similar antibiotics such as gemifloxacin (Factive), levofloxacin (Levaquin), moxifloxacin (Avelox), norfloxacin (Noroxin), and others.

Before taking Ciplox, tell your doctor if you have a heart rhythm disorder, kidney or liver disease, joint problems, diabetes, muscle weakness or trouble breathing, a condition called pseudotumor cerebri, a history of seizures, a history of head injury or brain tumor, low levels of potassium in your blood, a personal or family history of Long QT syndrome, or if you have ever had an allergic reaction to an antibiotic.

Do not take Ciplox with dairy products such as milk or yogurt, or with calcium-fortified juice. Avoid taking antacids, vitamin or mineral supplements, sucralfate (Carafate), or didanosine (Videx) powder or chewable tablets within 6 hours before or 2 hours after you take Ciplox. Ciprofloxacin may cause swelling or tearing of a tendon (the fiber that connects bones to muscles in the body), especially in the Achilles' tendon of the heel. Stop taking Ciplox and call your doctor at once if you have sudden pain, swelling, tenderness, stiffness, or movement problems in any of your joints. Rest the joint until you receive medical care or instructions.

You should NOT take Ciplox if:

you are also taking tizanidine (Zanaflex);

you have a history of myasthenia gravis; or

you are allergic to ciprofloxacin or similar medications such as gemifloxacin (Factive), levofloxacin (Levaquin), moxifloxacin (Avelox), ofloxacin (Floxin), norfloxacin (Noroxin), and others.

To make sure you can safely take Ciplox, tell your doctor if you have any of these other conditions:

heart rhythm disorder, especially if you take quinidine (Quin-G), disopyramide (Norpace), bretylium (Bretylol), procainamide (Pronestyl, Procan SR), amiodarone (Cordarone, Pacerone), or sotalol (Betapace);

a history of head injury or brain tumor;

a condition called pseudotumor cerebri (high pressure inside the skull that may cause headaches, vision loss, or other symptoms);

a history of allergic reaction to an antibiotic;

joint problems;

kidney or liver disease;

epilepsy or seizures;

diabetes;

muscle weakness or trouble breathing;

low levels of potassium in your blood (hypokalemia); or

a personal or family history of Long QT syndrome.

FDA pregnancy category C. It is not known whether Ciplox will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using it. Ciprofloxacin passes into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Ciplox may cause swelling or tearing of a tendon (the fiber that connects bones to muscles in the body), especially in the Achilles' tendon of the heel. These effects may be more likely to occur if you are over 60, if you take steroid medication, or if you have had a kidney, heart, or lung transplant. Stop taking Ciplox and call your doctor at once if you have sudden pain, swelling, tenderness, stiffness, or movement problems in any of your joints. Rest the joint until you receive medical care or instructions. Do not share Ciplox with another person (especially a child), even if they have the same symptoms you have.

Get emergency medical help if you have any of these signs of an allergic reaction to Ciplox: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using Ciplox and call your doctor at once if you have a serious side effect such as:

severe dizziness, fainting, fast or pounding heartbeats;

sudden pain, snapping or popping sound, bruising, swelling, tenderness, stiffness, or loss of movement in any of your joints;

diarrhea that is watery or bloody;

confusion, hallucinations, depression, unusual thoughts or behavior;

seizure (convulsions);

severe headache, ringing in your ears, dizziness, nausea, vision problems, pain behind your eyes;

pale or yellowed skin, dark colored urine, fever, weakness;

urinating less than usual or not at all;

easy bruising or bleeding;

numbness, tingling, or unusual pain anywhere in your body;

the first sign of any skin rash, no matter how mild; or

severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Less serious side effects:

nausea, vomiting;

dizziness or drowsiness;

blurred vision;

feeling nervous, anxious, or agitated; or

sleep problems (insomnia or nightmares).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.



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Zinacef Intravenous Uses, Side Effects, Interactions, Pictures, Warnings - Dosing, Zinacef

Zinacef intravenous

Uses

Cefuroxime is used to treat a wide variety of bacterial infections. It may also be used to prevent infection from certain surgeries. This medication belongs to a class of drugs known as cephalosporin antibiotics. It works by stopping the growth of bacteria.

How to use Zinacef intravenous

This medication is given by injection into a muscle or vein as directed by your doctor, usually every 8 hours. The dosage is based on your medical condition and response to treatment.

If you are using this medication at home, learn all preparation and usage instructions from your health care professional. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard medical supplies safely.

If you are using the frozen pre-mixed solution, thaw the bag at room temperature or in the refrigerator. If the bag is thawed in the refrigerator, let it sit at room temperature at least 1 hour before using. Do not thaw by putting in a water bath or microwaving. After thawing, shake well and squeeze the bag to check for leaks. Discard solution if the bag leaks. Do not re-freeze the solution after thawing.

Antibiotics work best when the amount of medicine in your body is kept at a constant level. Use this drug at evenly spaced intervals.

Continue to use this medication for the full time prescribed, even if symptoms disappear after a few days. Stopping the medication too early may result in a return of the infection.

Tell your doctor if your condition lasts or gets worse.

Side Effects

Swelling, redness, or pain at the injection site may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: easy bruising/bleeding, unusual tiredness, uncontrollable movements, mental/mood changes (such as confusion), seizures. signs of kidney problems (such as change in the amount of urine), signs of liver problems (such as nausea /vomiting that doesn't stop, loss of appetite, stomach /abdominal pain. yellowing eyes /skin. dark urine).

This medication may rarely cause a severe intestinal condition (Clostridium difficile - associated diarrhea ) due to a type of resistant bacteria. This condition may occur during treatment or weeks to months after treatment has stopped. Tell your doctor right away if you develop: diarrhea that doesn't stop, abdominal or stomach pain/cramping, blood /mucus in your stool.

Do not use anti-diarrhea products or narcotic pain medications if you have any of these symptoms because these products may make them worse.

Use of this medication for prolonged or repeated periods may result in oral thrush or a new yeast infection. Contact your doctor if you notice white patches in your mouth. a change in vaginal discharge. or other new symptoms.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction. including: rash. itching /swelling (especially of the face/tongue /throat), severe dizziness. trouble breathing .

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before using cefuroxime, tell your doctor or pharmacist if you are allergic to it; or to other antibiotics (such as penicillins, other cephalosporins); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease. stomach /intestinal diseases (such as colitis ).

Cefuroxime may cause live bacterial vaccines (such as typhoid vaccine) not to work as well. Do not have any immunizations /vaccinations while using this medication without the consent of your doctor.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Tell your doctor if you are pregnant before using this medication.

This medication passes into breast milk in small amounts and is unlikely to harm a nursing infant. Consult your doctor before breast - feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Although most antibiotics are unlikely to affect hormonal birth control such as pills, patch, or ring, a few antibiotics (such as rifampin. rifabutin ) can decrease their effectiveness. This could result in pregnancy. If you use hormonal birth control. ask your doctor or pharmacist for more details.

This medication may interfere with certain lab tests (including certain urine glucose tests), possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug.

Overdose

If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: seizures.

Notes

Do not share this medication with others.

Lab and/or medical tests (such as complete blood count. kidney function tests) should be done while you are using this medication. Keep all medical and lab appointments.

Missed Dose

For the best possible benefit, it is important to receive each scheduled dose of this medication as directed. If you miss a dose, contact your doctor or pharmacist right away to establish a new dosing schedule. Do not double the dose to catch up.

Storage

Consult the product instructions and your pharmacist for storage details. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Information last revised April 2016. Copyright(c) 2016 First Databank, Inc.

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Panleef (Nolvadex) Spiegazione

attenzione Panleef su puo essere la riparazione del cancro del seno. Panleef puo essere garantita anche per curare la probabilita di cancro al seno di avanzamento, specialmente nelle donne subito dopo il trattamento chirurgico, cosi come i raggi a causa di carcinoma duttale in situ (cA?ncer duttale in situ all'interno). Di tanto in tanto Panleef e effettivamente consegnato per generare donna dopo e anche a che fare con i sintomi di McCune-Albright.

Panleef e in realta eseguendo attraverso ostacolare il risultato di donna spazzatura conosciuto come ormone femminile. E 'davvero e antiestrogeno.

Panleef puo essere indicato anche come Tamoxifen, Blastofen, Istubal, Valodex, SOLTAMOX, Genox, Tamofen.

titolo generale associato con Panleef e in realta Tamoxifen.

Marca associata con Panleef Panleef e in realta.

Panleef (Nolvadex) dosaggio

Panleef e disponibile in:

10mg Lower Dose materiale di attrito

La dose reale associato con Panleef dipende dal tipo della propria malattia e condizione di benessere materiale 20mg regolare dose di attrito .

Ottenere Panleef un paio di volte al giorno con o senza pasto.

Ottenere Panleef pillole per via orale contemporaneamente ogni giorno con acqua potabile.

Se volete ottenere migliori risultati di solito non smettere di usare Panleef tutto ad un tratto.

Panleef (Nolvadex) manca associato a dosaggio

Di solito non si ottiene doppia dose. Nel caso in cui si salta il dosaggio e necessario portare una volta di tenere a mente per quanto riguarda al tuo carente. Quando e il momento per il dosaggio e necessario per portare avanti la propria normale routine di dosaggio.

Panleef (Nolvadex) Overdose

In caso di overdose Panleef e anche di evitare grandi e necessario controllare il vostro medico o anche il medico immediatamente. Associata con Panleef sovradosaggio: fuori controllo tutto il corpo tremante, instabilita, problemi con passeggiata, provocazione, vertigini, riflessi esagerati, problemi con inspirare ed espirare, formicolio.

Panleef (Nolvadex) spazio di archiviazione

Shop a temperature spaziali tra i venti e venticinque livelli di D (68 e settantasette livelli F) da umidita, luce e temperatura. Mantenere testo saldamente chiuso. Rafforzare qualsiasi tipo di farmaco intatto successivo al giorno di scadenza. Mantenere da raggiungere di bambini.

Panleef (Nolvadex) Effetti negativi

Panleef offre gli effetti negativi. Il piu tipico tendono ad essere:

pancia crampi materiale di attrito

nausea o vomito materiale di attrito

Materiale congestione di attrito

materiale di attrito calvizie

mancanza di materiale di attrito peso corporeo

disagio associato con il tessuto osseo o anche materiale di attrito del tumore

Materiale emicrania di attrito

conflicto insieme con gli uomini intima materiale di attrito soggiorno

materiale di attrito di testa vuota

disturbi depressivi materiale di attrito

sfreccia molto calde materiale di attrito

grave attrito esaurimento Materiale

molto meno tipico e gravi effetti negativi in ??tutto con Panleef:

le risposte di reazione allergiche (orticaria, inspirando ed espirando problemi, allergie, cosi come eruzione ) materiale di attrito

la massa muscolare del materiale di attrito debolezza

Materiale desiderio di attrito

materiale di attrito caldo

materiale di attrito uneasyness

ridotto la fame materiale di attrito

problemi con materiale d'attrito vista

materiale di montaggio di attrito

materiale di attrito ittero

la perdita irregolare di sangue o anche gli urti materiale di attrito

Gli effetti negativi sono indicazioni si basano su farmaci che si potrebbero utilizzare ma in piu si basano su proprie condizioni di benessere e altri aspetti.

Panleef (Nolvadex) Controindicazioni

Di solito non si ottiene Panleef nel caso in cui siete sensibili al fine di elementi Panleef.

Di solito non si ottiene Panleef se vi aspettate in caso contrario si ha intenzione di avere un bambino, altrimenti sei davvero una mamma medico.

Di solito non si ottiene Panleef per coloro che hanno una breve storia associata con la parte inferiore della gamba o anche petto coaguli di sangue.

Di solito non si ottiene Panleef nel caso in cui si sta utilizzando anticoagulanti, anastrozolo.

Diventa cauti con Panleef nel caso in cui si e afflitti da e hanno una breve storia associata a problemi della vista, diabete, infarto del miocardio, ictus cuore, maggiori quantita di flusso sanguigno di colesterolo, ipertensione.

Siate cauti con Panleef nel caso in cui si utilizza il fenobarbital; aminoglutetimide (tale perche Cytadren); farmaci per il trattamento di radiazioni malignita (ciclofosfamide (tale perche Neosar, Cytoxan), Letrozolo (Femara tale perche), bromocriptina (ad esempio perche Parlodel), i farmaci citotossici malignita; inibitori dell'aromatasi, fluorouracile o anche mitomicina D, medrossiprogesterone (tale perche Provera, entro Prempro Depo - Provera), rifampicina (ad esempio perche Rimactane, Rifadin)

Evitare che le persone che hanno infezioni batteriche o anche il comune raffreddore

Evitare pillole anticoncezionali

Prevenire le bevande alcoliche e il fumo di sigaretta.

Prevenire viaggio o anche di lavoro attrezzature.

Di solito non smettere di usare Panleef tutto ad un tratto.

Panleef (Nolvadex) Domande generali

Queen: Che cosa e esattamente Panleef?

Il: Panleef puo essere la medicina di alta qualita, che si consuma in rimediare del cancro al seno. Panleef puo essere garantita anche per curare la probabilita di cancro al seno di avanzamento, specialmente nelle donne subito dopo il trattamento chirurgico, cosi come i raggi a causa di carcinoma duttale in situ (cA?ncer duttale in situ all'interno). Di tanto in tanto Panleef e effettivamente consegnato per generare donna dopo e anche a che fare con McCune-Albright symptoms. A

Queen: Esattamente cosa si deve fare arrivare Panleef?

Il: Panleef e disponibile in pillole (10 milligrammi, venti mg). La dose reale associato con Panleef dipende dal tipo della propria malattia e condizione di benessere. Ottenere Panleef un paio di volte al giorno con o senza pasto. Prendi pillole Panleef per via orale contemporaneamente ogni giorno con acqua potabile. Se volete ottenere migliori risultati di solito non smettere di usare Panleef tutto ad un sudden. A

Queen: Esattamente quello che devo FAG situazione associata a sovradosaggio?

Il: Di solito non si ottiene pillole Panleef in grandi quantita. In caso di Panleef sovradosaggio, si deve controllare medico o anche il medico instantly. A

Queen: Si puo consumare davvero alcol?

Il: Assolutamente no, e davvero apprezzare alcolica beverages. A

Queen inaccettabili: che cosa sono esattamente gli effetti negativi Panleef?

Il: Panleef offre gli effetti negativi tipici per esempio: pancia crampi, nausea o vomito, congestione, la calvizie, la mancanza di peso corporeo, disagio associato con il tessuto osseo o addirittura tumori, emicrania, conflicto insieme con gli uomini di vita intima. vertigini, disturbi depressivi, sfreccia molto calde, grave esaurimento. Tuttavia in situazione associata con l'essere respinta associati ai componenti Panleef si e in grado di incontrare piu gravi effetti negativi: la massa muscolare qualche debolezza, desiderio, caldo, irrequietezza, fame ridotta, problemi con la vista, montaggio, ittero, associato a risposta reazione allergica (orticaria. problemi di inspirare ed espirare, allergie, infiammazioni, chiudendo), perdita di sangue irregolari o addirittura bumps. A

Queen: Che cosa esattamente sono generali e marchi associati Panleef?

Il: titolo generale associato con Panleef e in realta Tamoxifen. Marchio associato con Panleef e in realta Panleef. A

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Suvalan Car Rental, Suvalan

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Rent a car for your Suvalan stay

Car rental offices near Suvalan

We search over 500 approved car hire suppliers to find you the very best rental prices available. Hiring a car in more than 22 000 locations across 159 countries around the world is made as simple as possible. You don't have to browse through several websites and compare prices to find cheap car hire at - we will do it for you!

You have two options . either fill in the pick-up location in the form below or choose one of the car rental locations near Suvalan from the list above (car rental locations are sorted by the approximate distance from Suvalan ).

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Detailed FAQ section

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Liability Insurance

CDW, Theft Protection & Airport Tax

VAT Local Tax

Road Fund Tax (RFT)

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Break Down Assist

Choose one of the car rental locations near Suvalan from the list or fill in the pick-up location in the form above.

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1. Quote: Specify the request and get quotes

Start your search using the form above – choose your pick up location and specify your request: enter pick-up and drop-off dates and choose your preferred car type. Click the search button.

2. Book: Choose the deal you like

List of quotes will be provided. Choose the deal you like. Click the „rate details“ link to check the rental conditions specific to related quotation. The conditions may vary from vehicle to vehicle, country to country and supplier to supplier. By moving your mouse over the inclusive sign above the price information the offer details will appear. Click the book button.

3. Confirm: Book & receive instant confirmation

Finish your booking by entering your credit card details. The connection is encrypted, secure . You will receive your car rental voucher containing the booking details and instructions on how to collect the car.

Advantages of hiring a car in Suvalan with us

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Allows you to find the best Suvalan car rental offer from more than 500 car rental suppliers

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Rent a car at Suvalan and discover Azerbaydzhan Territor, Azerbaijan . Car hire service Suvalan offers low prices and a wide range of vehicles. You can compare offers from leading car hire suppliers like Avis, Europcar, Sixt or Thrifty as well as budget rental deals from Holiday Autos, Budget, Economy, EasyCar, or 121 carhire. Choose Suvalan car rental supplier according to your preferences . Every one should find a vehicle convenient for their stay in this location in Azerbaydzhan Territor, Azerbaijan.

Car categories

Combining offers from several providers you can usually choose from wide variety of cars, depending on your preferences and your passenger and baggage quantity requirements. We offer both car with automatic and manual transmission, some cars are provided with satellite navigation and/or air conditioning. However, please note: not all of below listed card are available in all locations at all times.

Mini cars: Chevrolet Matiz, Toyota Aygo or similar

Economy cars: Nissan Micra, Ford Fiesta, Peugeot 207, Toyota Yaris, Chevrolet Aveo or similar

Compact cars: Volkswagen Golf, Ford Focus, Toyota Auris, Chevrolet Cobalt or similar

Intermediate cars: Toyota Avensis, Ford Mondeo or similar

Standard cars: Audi A4, Volkswagen Passat, Pontiac Grand Prix or similar

Fullsize cars: BMW 3 series, Saab 9-3, Chevrolet Impala or similar

Premium cars: Mercedes C Class, Audi A6, Volvo V70 or similar

Luxury cars: Mercedes E Class, BMW X3, Ford Lincoln or similar

Minivan cars: Ford Galaxy, Chrysler Voyager, Volkswagen Touran, Mercedes Vito, Toyota Minibus, Renault Espace or similar

SUV cars: Suzuki Jimny (small), Nissan Pathfinder or Toyota Rav4 (medium), Volvo XC90 (large) or similar

Oversize cars: Fiat Mulltipa, Renault Scenic, Citroen Berlingo, Ford Focus Stationwagon or similar

Car rental companies offering a car hire service in Suvalan, Azerbaydzhan Territor, Azerbaijan strive to offer service and price to your satisfaction .

The benefit of Suvalan car rentals service provided here is a summary of offers different car hire possibilites, from large international companies to quality local car rental suppliers. The winner of the competition of their Suvalan offers is YOU: find the best Suvalan car hire rate . choose the deal you like. The booking proccess is simple, fast and secure.

The booking process

Information required during the booking process

The process of booking a car in Suvalan is secured and is made as simple as possible.

You will be asked to complete information about the driver and your credit card (for the purposes of online booking of car in Suvalan, Azerbaydzhan Territor, Azerbaijan). Credit card information is needed both on account of the advance payment and because of the blocking deposit for the event causing the car accident. The deposit amount varies case to case so it is necessary to read the booking conditions . If you rent a car at the airport, you should also enter a flight number.

After completing your reservation you will instantly receive a confirmation email . Please visit suppliers office after the arrival: you will receive keys for the vehicle and pay the rest amount for rent. Your car will be already waiting in the parking lot and you are ready to go .

How to amend your booking

You may change your reservation later if your travel plans change. You will be asked to provide your booking ID and details of the changes you wish to make. You can change your booking.

How to cancel your booking

We understand, that you may sometimes need to cancel the booking. Please read Cancellation Policy in full. If you rental is post-paid, which means that entire car rental amount is due on arrival at the rental desk, there is no cancellation fee . However if your booking is prepaid, you may be charged cancellation fee depending on the timing advance of the cancellation. In general, if the booking is cancelled within 7 days of the car rental booking date and at least 48 hours before confirmed pick up time, all funds will be reimbursed . If the booking is cancelled outside 7 days of the car rental booking date and at least 48 hours before the pickup time, all funds except the cancellation fee of EUR 25.00 and the card processing fee (where applicable), will be reimbursed. In most cases, no funds will be reimbursed, if the booking is cancelled less than 48 hours before the pickup time.

Please visit detailed FAQ section if you need more informaion.

Car Hire Voucher

Your rental voucher is a document which will be emailed to you and must be printed and produced at the rental desk at Suvalan when you pick-up your vehicle. The voucher will contain instructions on how to collect the car and contain the car hire company address you will be using, along with all their contact details. The Car Rental Voucher will also display your Car Rental Agent confirmation number. If you do not produce your voucher at the time of collection of the vehicle, the car rental supplier may apply a different rate than quoted or refuse to rent the vehicle. We cannot accept any appeal for a refund if you do not produce your voucher at the rental desk.

You can always view and print your voucher. Please remember to take it to the rental counter together with your driving licence and the credit card.

Payment Method

The booking can be paid for by either credit card or debit card. Credit card is required to match the drivers name. A deposit will be held on the credit card until it is returned. When hiring higher class vehicles two credit cards might be requested to be presented at the Suvalan car rental office.

Generally, the amount authorized covers the fuel deposit and the insurance excess. The actual amount depends on the rental duration, the age of the driver or the size of the vehicle.

Suvalan car hiring guide

Insurance Conditions

You should carefully read the conditions of the booking as different offers may vary in terms of the insurance . Sometimes the insurance doesn't apply to all parts of the vehicle, e. g. the damage of tire or car chassis might not be covered by the insurance. Consider your Azerbaydzhan Territor, Azerbaijan travel plans when analysing various offers. Make sure that car insurance is valid at your destination too. This is particularly important if you plan crossing state borders of Azerbaijan.

Insurance Coverage

Information on various insurance (e. g. collision damage waiver, theft waiver or third party liability protection) is included in the rate details listed at each offer . The renter may be held responsible for damage to or loss of tyres, windscreens, glass and undercarriage. Please check with the car rental agent on arrival. Ask for the breakdown assistance too.

Before you set for a Suvalan journey

Before you start an engine of the car rented at Suvalan for the first time, check that the car corresponds to the conditions specified in the contract. In particular, check the amount of fuel in the tank. It should be full; otherwise ask for the refilling of the fuel or change of the contract details. Do not forget to examine the car body for any defects in the paint, wheel disk or other visible parts of the vehicle.

Fuel Policy

Usually the rule as follows: pick up full, return full. This means you pick up the car with a full fuel tank and you should also return the vehicle with a full fuel tank. Some suppliers will charge for this service initially but will refund the fee on return, if the fuel tank is full (otherwise you will be charged for the missing). As the fuel policies might change, please ask at the supplier in Suvalan for the confirmation.

Additional Driver

You can add additional drivers for your booking. All additional drivers must be physically present at the Suvalan rental counter at the time of rental with their own driver's licence to sign the rental agreement. Depending on rate conditions, additional driver fee may be charged - this fee is then also payable at the counter. Usually additional driver permission can be obtained also on arrival at a small charge per person and day.

You will find information about additional drivers on your booking voucher. This section also shows other additional extras you have booked, for example baby seats and booster seats. These extras are usually not included in the price quoted and must be paid for on arrival.

Driving in Suvalan, Azerbaydzhan Territor, Azerbaijan

Drivers Age

During the booking process you will be asked about your age (see the form above). See the rate details for information about young drivers surcharge as it may not be included in the rental price (then it is to be paid at the Suvalan rental desk in the local currency). As the young drivers statistically cause more car accidents, they may be charged an extra fee. Minimum driving age varies between 16 and 21 years depending upon countries and regions. Car supplier in Suvalan will be happy to assist you in meeting local Azerbaydzhan Territor, Azerbaijan requirements.

Drivers License in Azerbaijan

Drivers must hold a full license. Limit of minimal period of holding a licence might be required. See the rate details of individual Suvalan car rental offers.

If the national driver license of the renter is not in Roman alphabet . an International Driver’s License (IDL) might be required. International driver's license must be accompanied by the driver's original domestic driving license.

International Driving Licence

Please check with the your car hire supplier (please see your voucher) if international driving license is required in Azerbaijan. The International Driving Licence (IDL) is recognised worldwide as a document that identifies its holder as a licensed driver in countries with different official language than your domestic license was issued. You must also provide a National Driver's Licence together with the international licence, otherwise it may not be accepted.

Mileage limit

Some car rental suppliers may apply restrictions to the distance you can travel per one day - see the rate details.

Length of your Suvalan, Azerbaydzhan Territor, Azerbaijan car rental

Sometimes it is not possible to rent a car for less then three days. Usually, the price per day decreases with the increasing length of the rent period.

Popular destinations close to Suvalan

In the following list, popular destinations near Suvalan are sorted by the approximate distance to there.

Suvalan Car Rental link options

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Barkley, Alben William - Biographical Information, Alben

Library of Congress

BARKLEY, Alben William, a Representative and a Senator from Kentucky and a Vice President of the United States; born near Lowes, Graves County, Ky. November 24, 1877; attended the public schools and graduated from Marvin College, Clinton, Ky. in 1897; attended Emory College, Oxford, Ga. and the University of Virginia Law School, Charlottesville, Va.; admitted to the bar in 1901 and commenced practice in Paducah, McCracken County, Ky.; prosecuting attorney for McCracken County, Ky. 1905-1909; judge of McCracken County Court 1909-1913; elected as a Democrat to the Sixty-third and to the six succeeding Congresses (March 4, 1913-March 3, 1927); did not seek renomination in 1926, having become a candidate for United States Senator; elected to the United States Senate in 1926; reelected in 1932, 1938, and again in 1944, and served from March 4, 1927, until his resignation on January 19, 1949; majority leader 1937-1947; minority leader 1947-1949; elected Vice President of the United States on the Democratic ticket with President Harry S. Truman in 1948; inaugurated January 20, 1949, for the term ending January 20, 1953; again elected to the United States Senate and served from January 3, 1955, until his death in Lexington, Va. April 30, 1956; interment in Mount Kenton Cemetery, on Lone Oak Road, near Paducah, Ky.

Dictionary of American Biography ; Barkley, Alben. That Reminds Me. Garden City, N. Y. Doubleday, 1954; Davis, Polly. Alben Barkley: Senate Majority Leader and Vice President . New York: Garland Publishing, Inc. 1979.



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Alermuc, Alermuc

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Important Notice: The Drugs. com international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

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Loratadine (Loratadine)

What is your Risk Rating for this medicine?

The risk of serious side effects for taking this medicine can be different if you take other medicines or if you suffer from a condition. Get your Risk Rating by creating a profile in a few steps.

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DISCLAIMER: MediGuard is not intended to be a substitute for professional medical advice. MediGuard cannot and does not take into consideration every possible interaction or account for individual responses to medicine. Different individuals may respond to medication in different ways. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective, or appropriate for any given patient. Always seek the advice of a qualified health provider with any questions you may have before making any changes to your treatment. The use of the MediGuard site and its content is at your own risk. The MediGuard site and the information contained in it is intended for users in the United States and information in other countries may be different.

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Loratadine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. Alavert is used for relieving symptoms of seasonal allergies.

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Do not crush, chew, or break the regular loratadine tablet. Swallow the pill whole. Measure liquid medicine with a special dose-measuring spoon or medicine cup, not with a regular table spoon.

Alavert is usually taken once per day. Follow your doctor's instructions.

To take Alavert orally disintegrating tablet:

Keep the tablet in its blister pack until you are ready to take the medicine. Open the package and peel back the foil from the tablet blister. Do not push a tablet through the foil or you may damage the tablet.

Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing.

Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing.

Using dry hands, remove the tablet and place it on your tongue. It will begin to dissolve right away.

Take Alavert by mouth with food.

Store at room temperature between 20 and 25 degrees C and away from moisture, light and heat. Do not store in the bathroom. Keep in a tight, light-resistant container. Keep Alavert out of the reach of children and away from pets.

You should not take Alavert if:

You are allergic to loratadine or to desloratadine (Clarinex). Ask a doctor or pharmacist if it is safe for you to take this medicine if you have:

kidney disease; Ask a doctor or pharmacist if it is safe for you to take this medicine if you have:

You should not take this medication if you are allergic to loratadine or to desloratadine (Clarinex).

FDA pregnancy category B: This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Loratadine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Loratadine disintegrating tablets (Claritin Reditab, Alavert) may contain phenylalanine. Talk to your doctor before using this form of loratadine if you have phenylketonuria (PKU). Do not give this medication to a child younger than 6 years old without the advice of a doctor.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

fast or uneven heart rate;

feeling like you might pass out;

jaundice (yellowing of your skin or eyes);

seizures (convulsions).

Call your doctor at once if you noticed these serious side effects. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Less serious side effects may include:

headache;

skin rash;

nervousness;

nosebleed;

feeling tired or drowsy;

eye redness, blurred vision;

stomach pain, diarrhea;

dry mouth, sore throat hoarseness.

Loratadine

Click for further information on drug naming conventions and International Nonproprietary Names .

Important Notice: The Drugs. com international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

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Cefuroxime - Side Effects, Dosage, Interactions, Zinoximor

Cefuroxime

Cefuroxime is a prescription drug available under the brand names Ceftin and Zinacef.

It's an antibiotic used to treat certain infections caused by bacteria, such as sinus infections, throat infections, Lyme disease. and gonorrhea.

Cefuroxime was originally approved by the Food and Drug Administration (FDA) under the brand name Ceftin, manufactured by GlaxoSmithKline, in 1987.

Cefuroxime Warnings

You should not take cefuroxime if you:

Are allergic to cefuroxime or any of the other ingredients contained in the drug

Are taking Theracrys (BCG live intravesical)

Talk to your doctor before taking cefuroxime if you:

Are allergic to penicillin

Are allergic to other antibiotics such as ceflacor, cefdinir, Keflex (cephalexin), or antibiotics in the cephalosporin class

Have kidney or liver problems

Have seizures

Have poor eating habits or suffer from malnutrition

Have recently had an either infection or inflammation of your intestines while or after taking antibiotics

Cefuroxime may reduce the effects of your birth control (pills, patches, or injections).

You may need to use a back-up form of birth control while taking cefuroxime.

Pregnancy and Cefuroxime

Cefuroxime falls under the FDA's Pregnancy Category B, which means that it's generally safe for your unborn baby.

Regardless, you should tell your doctor if you are pregnant or plan to become pregnant before taking this medication.

Cefuroxime is found in breast milk. Tell your doctor if you are breastfeeding or plan to breastfeed before you take this medication.

Cefuroxime (Ceftin) Side Effects

Common side effects of cefuroxime include:

Nausea, vomiting, and diarrhea

Kidney problems

Diaper rash

Yeast infection

An allergic reaction

Serious side effects of cefuroxime include but are not limited to:

Life-threatening allergic reaction called anaphylaxis in which you may have trouble breathing, your throat closes up, and your skin breaks out into hives

Swelling of the face, including eyes, lips, mouth, tongue, and throat

Severe and possibly life-threatening skin-reactions like Steven-Johnsons syndrome or toxic epidermal necrolysis (TENs)

Blood disorders like low platelet count or low levels of all blood cells

Low levels of white blood cells

Seizures

A severe form of diarrhea noted by loose, watery stool and a foul smell that is much worse than normal

Cefuroxime (Ceftin) Interactions

It's always important to share with your doctor and pharmacist all of the medications you are taking.

This includes prescription and over-the-counter (OTC) medications, supplements like vitamins and other dietary supplements (nutritional shakes, protein powders, etc.), herbals, and any illegal or recreational drugs.

You should not take cefuroxime if you are taking Theracrys (BCG live intravesical).

Some other medications that have serious interactions with Cefuroxime include:

Acid-reflux medications like Tagamet (cimetidine), Dexilant (deslansoprazole), and Aciphex (rabeprazole)

Other acid-reflux medications like Pepcid (famotidine), Zantac (ranitidine), and Axid (nizatidine)

Vivotif (live typhoid vaccine)

Aluminum hydroxide, calcium carbonate, magnesium hydroxide, sodium bicarbonate

Cellcept (mycophenolate mofetil) and Myfortic (mycophenolic acid)

Cefuroxime and Alcohol

You should avoid or limit alcohol consumption while taking cefuroxime.

Cefuroxime and Grapefruit Juice

You should avoid eating grapefruit and drinking grapefruit juice while taking cefuroxime.

Grapefruit juice slows down how quickly the body is able to break down cefuroxime, which could cause levels in the blood to rise dangerously high.

Cefuroxime (Ceftin) Dosage

Cefuroxime comes in 250 mg and 500 mg tablets.

Doses typically range from 250 mg twice a day to 500 mg twice a day to be taken for 5 to 10 days for most infections.

Lyme disease symptoms may be treated for up to 20 days.

For gonorrhea, your doctor may prescribe a one-time dose of 1000 mg.

It is very important to take cefuroxime exactly as your doctor prescribes and to finish taking all of the medication -- even if you start to feel better or your symptoms disappear.

Otherwise, the infection might return and become much more difficult to treat.

Cefuroxime Overdose

If you suspect an overdose of cefuroxime you should contact a poison control center or emergency room immediately.

You can get in touch with a poison control center at (800) 222-1222.

Missed Dose of Cefuroxime

If you miss a dose of Cefuroxime, try to take it as soon as you remember.

If it's almost time for the next dose, skip the missed dose and take your next dose at the regular time.

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Tonal - Definition Of Tonal By The Free Dictionary, Tonal

tonal

adj → klanglich. Klang - ; (Mus: = regarding form ) → tonal ; (Art) → farblich. Farb - ; tonal variation → Klangvariation f ; (in colours) → Farbabstufung f ; tonal effects (in music) → Klangeffekte pl ; (in painting) → Farbeffekte pl ; tonal music → tonale Musik ; tonal value (Phot) → Farbwert m

tonal

tone

1. (the quality of) a sound, especially a voice. He spoke in a low/angry/gentle tone; He told me about it in tones of disapproval; That singer/violin/piano has very good tone. toon ???????? ????? тон tom ton, zvuk der Ton tone ?????. ???? tono toon, kola ??? aanensavy ton ???? ??? ton, boja glasa hang; tonus suara tonn tono ???? ?? tonas tonis nada toon klang. tone ton ????? ???? ??: ???? ( ????? ?? ????? ???? ??? )? ????: ???? ??? ????????? ???: ?????? ??????? ???? ( ?? ????? ?? tom ton, timbru тон ; тембр ton, zvuk ton ton ton, tonfall ?????????????? ton ??,?? тон ????? gi?ng ??,??

2. a shade of colour. various tones of green. skakering ??????? ?????? цвят tom ton der Farbton tone; nuance ???????? tono varvitoon ???? ?? ??? varisavy ton ???? ????-???? ton boje (szin)arnyalat sifat litbrig?i, tonn tono ?? ?? atspalvis tonis; nokrasa warna tint nyanse. fargetone odcien ??? tom ton, nuanta оттенок ton odtenek ton [farg]ton ????? ton ?? тон, відтінок ??? ?? ???? mau nh?t ??

3. firmness of body or muscle. Your muscles lack tone – you need exercise. tonus, styfheid ??????? здравина tonus tonus die Spannkraft styrke ?????? ????? tono pingus ?????? ????? kiinteys tonus ??????? ???? tonus, napetost tonus (izmoke stb.) kekekaran gott likamlegt astand tono ????? ?? stangrumas tonuss kepejalan tonus tonus elastycznosc ? ??? ?????? ???? tonus tonus тонус tonus tonus tonus spanst ????????????????????????????????????? ? ????????? guc. beden sagl?g? ?????? тонус; сила ??? ? ????? ?? ???? s? ch?c co ??????

4. in music, one of the larger intervals in an octave eg between C and D. toon ?????? ???????? цял тон tom ton der (Ganz-)Ton heltone ????? tono toon, suur sekund ?? kokosavelaskel ton ??? ??? ton egesz hang nada heiltonn tono ?? ??? tonacija tonis ton toon heltone ton ?? tom ton тон ton ton ton helton ?????????? ton. aral?k ??? тон ???? ????? ??? ??? ???? quang tru?ng ???

to fit in well; to blend. The brown sofa tones (in) well with the walls. vermeng, meng in ????????? ??? сливам се combinar ladit (s) harmonisieren harmonere ?????????????, ????????. ???? combinar. hacer juego. ir bien juntos sobima ??? ????? ????? ?? sopia s'harmoniser ?????????? ??? - ?????? slagati se, uklopiti se szinben osszeillik serasi fara (vel) vi? intonarsi ???? ? ???? dereti harmonet; pieskanoties; iedereties padan benar kleuren bij sta til. passe/harmonisere med harmonizowac ??? ?????? ???? ?????? ??? ????? combinar a se potrivi (cu) гармонировать ladit (s) ujemati se uklapati se ga ton i ton, harmoniera ???????????????? rengi uygun dusmek ???? гармоніювати ?? ????? ????? ????? ???? phu h?p ????

of musical tones. tonaal ?????? тонален tonal tonovy; tonalni Ton-. tone - ??????? tonal kola - ????? savel - tonal ???????? ???? ?????? tonski, tonalan hang-; tonalis nada musik tontegunda - tonale. di tono ??? ??? tonalus tonals nada tonaal tonal tonalny ???? ???? ??? tonal tonal тональный tonovy; tonalny tonski tonski tonal, ton - ??????????????????? ses perdesine/tonuna ait ??? тональний ?????? ?? ????? ?? ????? (thu?c) gi?ng ???

without tone; with no variation in sound etc . She spoke in a toneless voice. toonloos ????? ?????? ?? ?????????? ????????????? безизразен monotono nezvucny tonlos tonlos ?????? monotono kolatu ?? ???? ?? ???? variton atone ????? ?????? ???????, ??? ???? bezvucan, monoton hangtalan; szintelen datar aherslulaus monotono ??? ??, ??? ?? monotoniskas neskanigs; neizteiksmigs tdk bernada toonloos tonlos. monoton matowy. bezbarwny ?? ??? monotono inexpresiv монотонный nezvucny brezbarven bezizrazajan entonig, klanglos ???????????? tekduze. perdesiz, monoton ???? невиразний ?? ?????? ?? ?? thi?u sinh khi, khong co d? rung ???,????

toonloos ????? ?????????? ?? ?????????? ????????????? безизразно monotonamente bezvyrazne tonlos tonlost ????? monotonamente kolatult ?? ??? ??? varittomasti sans timbre ????????? ?????? ?????????? ??, ???????????? bezvucno, monotono hangtalanul; szintelenul secara datar aherslulaust in maniera monotona ??? ??, ??? ?? monotoniskai neskanigi; neizteiksmigi tanpa nada toonloos tonlost. monotont matowym glosem, matowo ?? ??? ???? ??? monotonamente inexpresiv монотонно bezvyrazne brezbarvno bezizrazajno entonigt, klanglost ????????????????? monoton bir sekilde ??? невиразно ?? ??? ??? ?? ????? y?u, thi?u sinh khi ???

to make or become softer, less harsh etc . He toned down some of his criticisms. minder erg maak ???????? ?????????? намалявам силата на abrandar zmirnit, zmekcit mildern nedtone; mildne ????????. ???????? reducir. suavizar pehmendama, mahenema ?? ??? ???? ????? pehmentaa attenuer. adoucir ?????????? ???? ???? ublaziti, umeksati letompit memperlunak draga ur, milda attenuare ???? (??, ??, ?? ??)? ???? ?? susvelninti, susvelneti notuset; mikstinat melembutkan verzachten tone ned. dempe. svekke lagodzic. lagodniec ? ?? ?? ?? ??? ??? ???? abrandar a (se) indulci; a (se) potoli смягчать zmiernit ublaziti (se) ublaziti tona ner ????????????????????????????? yumusatmak ??? пом'якшувати ??? ????? ????? ???? gi?m am d? ??

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Buy Cheap Pain Relief - Perdophen Pediatrie (Brand Name Motrin) (Ibuprofen) Buy Pain Relief - Perdop

Motrin is used for treating rheumatoid arthritis, osteoarthritis, menstrual cramps, or mild to moderate pain. Motrin is an NSAID. NSAIDs treat the symptoms of pain and inflammation. They do not treat the disease that causes those symptoms.

Use Motrin as directed by your doctor.

Take Motrin by mouth with or without food. It may be taken with food if it upsets your stomach. Taking it with food may not lower the risk of stomach or bowel problems (eg, bleeding, ulcers). Talk with your doctor or pharmacist if you have persistent stomach upset.

Take Motrin with a full glass of water (8 oz/240 mL) as directed by your doctor.

If you miss a dose of Motrin and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose. Go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about the proper use of Motrin .

Store Motrin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Motrin out of the reach of children and away from pets.

Active Ingredient: Ibuprofen.

Do NOT use Motrin if:

you are allergic to any ingredient in Motrin

you have had a severe allergic reaction (eg, severe rash, hives, trouble breathing, growths in the nose, dizziness) to aspirin or an NSAID (eg, ibuprofen, celecoxib)

you have recently had or will be having bypass heart surgery

you are in the last 3 months of pregnancy.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Motrin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal product, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a history of kidney or liver disease, diabetes, or stomach or bowel problems (eg, bleeding, perforation, ulcers)

if you have a history of swelling or fluid buildup, lupus, asthma, or growths in the nose (nasal polyps), or mouth inflammation

if you have high blood pressure, blood disorders, bleeding or clotting problems, heart problems (eg, heart failure), or blood vessel disease, or if you are at risk for any of these diseases

if you have poor health, dehydration or low fluid volume, or low blood sodium levels, you drink alcohol, or you have a history of alcohol abuse.

Some medicines may interact with Motrin. Tell your health care provider if you are taking any other medicines, especially any of the following:

Anticoagulants (eg, warfarin), aspirin, corticosteroids (eg, prednisone), heparin, or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) because the risk of stomach bleeding may be increased

Probenecid because it may increase the risk of Motrin 's side effects

Cyclosporine, lithium, methotrexate, or quinolones (eg, ciprofloxacin) because the risk of their side effects may be increased by Motrin

Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril) or diuretics (eg, furosemide, hydrochlorothiazide) because their effectiveness may be decreased by Motrin.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Motrin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Motrin may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Motrin with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Serious stomach ulcers or bleeding can occur with the use of Motrin. Taking it in high doses or for a long time, smoking, or drinking alcohol increases the risk of these side effects. Taking Motrin with food will NOT reduce the risk of these effects. Contact your doctor or emergency room at once if you develop severe stomach or back pain; black, tarry stools; vomit that looks like blood or coffee grounds; or unusual weight gain or swelling.

Do not take more than the recommended dose or use for longer than prescribed without checking with your doctor.

Motrin has ibuprofen in it. Before you start any new medicine, check the label to see if it has ibuprofen in it too. If it does or if you are not sure, check with your doctor or pharmacist.

Do not take aspirin while you are using Motrin unless your doctor tells you to.

Lab tests, including kidney function, complete blood cell counts, and blood pressure, may be done to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.

Use Motrin with caution in the elderly; they may be more sensitive to its effects, including stomach bleeding and kidney problems.

Motrin should be used with extreme caution in children; safety and effectiveness in children have not been confirmed.

Pregnancy and breast-feeding: Motrin may cause harm to the fetus. Do not take it during the last 3 months of pregnancy. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Motrin while you are pregnant. It is not known if Motrin is found in breast milk. Do not breastfeed while taking Motrin .

All medicines can cause side effects, but many people have no, or minor, side effects.

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Constipation; diarrhea; dizziness; gas; headache; heartburn; nausea; stomach pain or upset.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; trouble breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody or black, tarry stools; change in the amount of urine produced; chest pain; confusion; dark urine; depression; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; mental or mood changes; numbness of an arm or leg; one-sided weakness; red, swollen, blistered, or peeling skin; ringing in the ears; seizures; severe headache or dizziness; severe or persistent stomach pain or nausea; severe vomiting; shortness of breath; stiff neck; sudden or unexplained weight gain; swelling of hands, legs, or feet; unusual bruising or bleeding; unusual joint or muscle pain; unusual tiredness or weakness; vision or speech changes; vomit that looks like coffee grounds; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.



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Сновител" /> Латинское название: Snovitel Фармакологические группы: Снотворные средства Действующее вещество (МНН) Золпидем* (Zolpidem*)

Применение: Бессонница (аномальная, транзиторная, хроническая).

Противопоказания: Гиперчувствительность, острая или тяжелая дыхательная недостаточность, миастения, тяжелые нарушения функции печени, беременность, кормление грудью, детский возраст (до 15 лет).

Применение при беременности и кормлении грудью: Противопоказано при беременности. На время лечения следует прекратить грудное вскармливание.

Побочные действия: Дневная сонливость, антероградная амнезия, астенизация, головная боль, головокружение, спутанность сознания, нарушения зрения, диплопия, эйфория, изменение походки и поведенческих реакций (агрессивность, галлюцинации), кошмарные сновидения, боль в животе, икота, тошнота, рвота, диарея, кожные высыпания и зуд, лекарственная зависимость (при длительном применении).

Взаимодействие: Потенцирует депримирующий эффект наркотических анальгетиков, барбитуратов, антидепрессантов (с седативным компонентом), нейролептиков, антигистаминных препаратов, алкоголя. В сочетании с имипрамином или хлорпромазином действует аддитивно. Флумазенил устраняет снотворное влияние.

Передозировка: Симптомы: нарушение сознания (от полубессознательного состояния до легкой комы), кардиоваскулярные и респираторные нарушения. Лечение: немедленное промывание желудка, в качестве антидота рекомендуется флумазенил. Показан мониторинг жизненно важных функций (дыхание, пульс, АД и др.), при необходимости - симптоматическая терапия. При возбуждении следует воздержаться от введения любых седативных препаратов. Диализ малоэффективен.

Способ применения и дозы: Внутрь, непосредственно перед сном (уже лежа в постели), однократно. До 65 лет - 10 мг, старше 65 лет - 5 мг, при необходимости не более 10 мг. Курс лечения при аномальной бессоннице - 2-5 дней, при транзиторной - не более 4 нед.

Меры предосторожности: Поскольку нарушения сна могут быть предвестником серьезных соматических и психических заболеваний, симптоматическое лечение бессонницы может быть начато только после детального обследования пациента. В период лечения необходимо стремиться к созданию благоприятных условий для сна. Несоблюдение данной рекомендации или частое бесконтрольное использование высоких доз повышают риск формирования лекарственной зависимости. При нарушении функции печени препарат назначается в половинных дозах. В терминальной стадии почечной недостаточности может назначаться в обычных дозах в условиях адекватного мониторинга. Пожилым людям рекомендуется прием только малых доз (обязательно тщательное наблюдение). В период лечения необходимо отказаться от приема алкоголя. Не следует применять во время работы водителям транспортных средств и людям, профессия которых связана с повышенной концентрацией внимания.

Торговые названия препаратов с действующим веществом Золпидем* (Zolpidem*)

Гипноген (Hypnogen) Ивадал (Ivadal) Санвал (Sanval) Золпидема тартрат (Zolpidem tartrate) Нитрест (Nitrest) Сновител (Snovitel)

Copyright © MedCatalog. net All rights reserved Перед применением любого из вышеперечисленных препаратов обязательно Проконсультируйтесь со своим Лечащим Врачом



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Littman Drug Corp - Pharma Companies - Drug Usage - Diseases

Littman Drug Corp medicines list

Littman Drug Corp is a manufacturer of medicnes in India. The following are the list of medicines made by Littman Drug Corp

Anti-anginal drugs - brand named Angiozem is manufactured by Littman Drug Corp and mainly contains Diltiazem Hydrochloride Angiozem comes under medical category C08DB01 - Diltiazem Read More: Angiozem Tablets

Beetab - Tablets - Film-Coated

Vitamin B complex - brand named Beetab - Film-Coated is manufactured by Littman Drug Corp and mainly contains Vitamin B1 Beetab - Film-Coated comes under medical category A11EX - Vitamin B-complex, other combinations Read More: Beetab Tablets Film Coated

Drugs acting on musculo-skeletal system - brand named Begesic - Cream is manufactured by Littman Drug Corp and mainly contains Cajeput Oil Begesic - Cream comes under medical category D02AF - Salicylic Acid preparations Read More: Begesic Cream

Anti-anginal drugs - brand named Bezam is manufactured by Littman Drug Corp and mainly contains Amlodipine Besylate Bezam comes under medical category C08CA01 - Amlodipine Read More: Bezam Tablets

Dyslipidaemic agents - brand named Cholestad is manufactured by Littman Drug Corp and mainly contains Simvastatin Cholestad comes under medical category C10AA01 - Simvastatin Read More: Cholestad Tablets

Anti-anginal drugs - brand named Durabeta is manufactured by Littman Drug Corp and mainly contains Atenolol Durabeta comes under medical category C07AB03 - Atenolol Read More: Durabeta Tablets

Loop diuretics - brand named Edemann is manufactured by Littman Drug Corp and mainly contains Furosemide Edemann comes under medical category C03CA01 - Furosemide Read More: Edemann Tablets

Dyslipidaemic agents - brand named Lipigem - Capsules is manufactured by Littman Drug Corp and mainly contains Gemfibrozil Lipigem - Capsules comes under medical category C10AB04 - Gemfibrozil Read More: Lipigem Capsules

Aminopenicillins - brand named Littmox - Capsules is manufactured by Littman Drug Corp and mainly contains Amoxicillin Trihydrate Littmox - Capsules comes under medical category J01CA04 - Amoxicillin Read More: Littmox Capsules

Antidiabetic agents - brand named Lodulce is manufactured by Littman Drug Corp and mainly contains Glyburide Lodulce comes under medical category A10BB01 - Glibenclamide Read More: Lodulce Tablets

Hyperuricemia and gout preparations - brand named Loricid is manufactured by Littman Drug Corp and mainly contains Allopurinol Loricid comes under medical category M04AA01 - Allopurinol Read More: Loricid Tablets

Antidiabetic agents - brand named Neomet is manufactured by Littman Drug Corp and mainly contains Metformin Hydrochloride Neomet comes under medical category A10BA02 - Metformin Read More: Neomet Tablets

Antacids - brand named Opraz - Capsules is manufactured by Littman Drug Corp and mainly contains Omeprazole Opraz - Capsules comes under medical category A02BC01 - Omeprazole Read More: Opraz Capsules

Peptica - Tablets - Film-Coated

Antacids - brand named Peptica - Film-Coated is manufactured by Littman Drug Corp and mainly contains Ranitidine Hydrochloride Peptica - Film-Coated comes under medical category A02BA02 - Ranitidine Read More: Peptica Tablets Film Coated

Cough and cold preparations - brand named Phlemasol is manufactured by Littman Drug Corp and mainly contains Ambroxol Hydrochloride Phlemasol comes under medical category R05CB06 - Ambroxol Read More: Phlemasol Tablets

Antivertigo drugs - brand named Vertisin is manufactured by Littman Drug Corp and mainly contains Cinnarizine Vertisin comes under medical category N07CA02 - Cinnarizine Read More: Vertisin Tablets

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Kesium Chewable Tablets

Kesium Chewable Tablets are for the treatment of infections caused by ß-lactamase producing strains of bacteria sensitive to amoxicillin in combination with calvulanic acid and where clinical experience and/or sensitivity testing indicates the product as the drug of choice. The tablets are beige in colour, oblong and have an equal break line. They are available in 4 sizes: Kesium 50mg, Kesium 62.5mg, Kesium 250mg and Kesium 500mg.

Kesium Chewable Tablets are for the treatment of infections caused by ß-lactamase producing strains of bacteria sensitive to amoxicillin in combination with clavulanic acid and where. [More info]

Kesium Chewable Tablets are for the treatment of infections caused by ß-lactamase producing strains of bacteria sensitive to amoxicillin in combination with clavulanic acid and where. [More info]

Kesium Chewable Tablets are for the treatment of infections caused by ß-lactamase producing strains of bacteria sensitive to amoxicillin in combination with clavulanic acid and where. [More info]

Kesium Chewable Tablets are for the treatment of infections caused by ß-lactamase producing strains of bacteria sensitive to amoxicillin in combination with clavulanic acid and where. [More info]

Kesium Chewable Tablets are for the treatment of infections caused by ß-lactamase producing strains of bacteria sensitive to amoxicillin in combination with clavulanic acid and where. [More info]

Target Species: 50 and 62.5 mg tablets - cats and dogs 250 and 500 mg tablets - dogs

Indications for Use, Specifying the Target Species: For the treatment of the following infections caused by β lactamase producing strains of bacteria sensitive to amoxicillin in combination with clavulanic acid and where clinical experience and/or sensitivity testing indicates the product as the drug of choice: - Skin infections (including superficial and deep pyodermas) associated with Staphylococcus spp. - Urinary tract infections associated with Staphylococcus spp, Streptococcus spp , Escherichia coli and Proteus mirabilis . - Respiratory tract infections associated with Staphylococcus spp, Streptococcus spp and Pasteurella spp . - Digestive tract infections associated with Escherichia coli . - Infections of the oral cavity (mucous membrane) associated with Pasteurella spp, Streptococcus spp, Escherichia coli.

Contraindications Do not use in animals with known hypersensitivity to penicillins or other susbstances of the β-lactam group or to any excipients. Do not use in animals with serious dysfunction of the kidneys accompanied by anuria and oliguria. Do not administer to gerbils, guinea pigs, hamsters, rabbits and chinchillas. Do not use in horses and ruminating animals. Do not use where resistance to this combination is known to occur.

Special Warnings for each target species None known

Special Precautions for Use i) Special precautions for use in animals Official, national and regional antimicrobial policies with respect to the use of broad-spectrum antibiotics should be taken into account. Do not use in case of bacteria sensitive to narrow spectrum penicillins or to amoxicillin as single substance. It is advised that upon initiating therapy appropriate sensitivity testing is performed and that therapy is continued only after susceptibility to the combination has been established. Use of the product deviating from the instructions given in the SPC may increase the prevalence of bacteria resistant to the amoxicillin/clavulanate, and may decrease the effectiveness of treatment with beta-lactam antibiotics In animals with hepatic and renal dysfunction, the dosing regimen should be carefully evaluated and the use of the product based on a risk/benefit evaluation by the veterinary surgeon. Caution is advised in the use in small herbivores other than those in the section 4.3. The potential for allergic cross-reactions with other penicillin derivates and cephalosporins should be considered ii) Special precautions to be taken by the person administering the veterinary medicinal product to animals Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillins may lead to cross-reactions to cephalosporins and vice versa. Allergic reactions to these substances may occasionally be serious. Do not handle this product if you know you are sensitised, or if you have been advised not to work with such preparations. Handle this product with great care to avoid exposure, taking all recommended precautions. If you develop symptoms following exposure such as a skin rash, you should seek medical advice and show the doctor this warning. Swelling of the face, lips or eyes or difficulty with breathing are more serious symptoms and require urgent medical attention. Wash hands after use.

Adverse Reactions (Frequency and Seriousness) Mild gastrointestinal signs (diarrhoea, and vomiting) may occur after administration of the product. Treatment may be discontinued depending on the severity of the undesirable effects and a benefit/risk evaluation by the veterinary surgeon. Allergic reactions (skin reactions, anaphylaxis) may occasionally occur. In these cases, administration should be discontinued and a symptomatic treatment given.

Use during Pregnancy, Lactation or Lay Laboratory studies in rats and mice have not produced any evidence of teratogenic, foetotoxic or maternotoxic effects. In pregnant and lactating animals, use only according to the benefit/risk assessment by the responsible veterinarian.

Interaction with other Medicinal Products and Other Forms of Interaction Chloramphenicol, macrolides, sulfonamides and tetracyclines may inhibit the antibacterial effect of penicillins because of the rapid onset of bacteriostatic action. Penicillins may increase the effect of aminoglycosides.



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Nitroglycerin Sublingual Medlineplus Drug Information, Nitroglycerol

Nitroglycerin Sublingual

Nitroglycerin sublingual tablets are used to treat episodes of angina (chest pain) in people who have coronary artery disease (narrowing of the blood vessels that supply blood to the heart). It is also used just before activities that may cause episodes of angina in order to prevent the angina from occurring. Nitroglycerin is in a class of medications called vasodilators. It works by relaxing the blood vessels so the heart does not need to work as hard and therefore does not need as much oxygen.

How should this medicine be used?

Nitroglycerin comes as a sublingual tablet to take under the tongue. The tablets is usually taken as needed, either 5 to 10 minutes before activities that may cause attacks of angina or at the first sign of an attack. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take nitroglycerin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Nitroglycerin may not work as well after you have used it for some time or if you have taken many doses. Take the fewest tablets needed to relieve the pain of your attacks. If your angina attacks happen more often, last longer, or become more severe at any time during your treatment, call your doctor.

Talk to your doctor about how to use nitroglycerin tablets to treat angina attacks. Your doctor will probably tell you to sit down and take one dose of nitroglycerin when an attack begins. If your symptoms do not improve very much or if they worsen after you take this dose you may be told to call for emergency medical help right away. If your symptoms do not go away completely after you take the first dose, your doctor may tell you to take a second dose after 5 minutes have passed and a third dose 5 minutes after the second dose. Call for emergency medical help right away if your chest pain has not gone away completely 5 minutes after you take the third dose.

Do not chew, crush, or swallow nitroglycerin sublingual tablets. Instead, place the tablet under your tongue or between your cheek and gum and wait for it to dissolve. You may feel burning or tingling in your mouth as the tablet dissolves. This is normal but is not a sign that the tablet is working. Do not be concerned that the tablet is not working if you do not feel the burning or tingling.

Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking or using nitroglycerin,

tell your doctor and pharmacist if you are allergic to nitroglycerin patches, capsules, tablets, ointment, or spray; any other medications; or any of the ingredients in nitroglycerin sublingual tablets. Ask your pharmacist for a list of the ingredients.

tell your doctor if you are taking riociguat (Adempas) or if you are taking or have recently taken a phosphodiesterase inhibitor (PDE-5) such as avanafil (Stendra), sildenafil (Revatio, Viagra), tadalafil (Adcirca, Cialis), and vardenafil (Levitra, Staxyn). Your doctor may tell you not to take nitroglycerin if you are taking one of these medications.

tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: aspirin; beta blockers such as atenolol (Tenormin), carteolol. labetalol (Trandate), metoprolol (Lopressor), nadolol (Corgard), propranolol (Inderal), sotalol (Betapace), and timolol; calcium channel blockers such as amlodipine (Norvasc), diltiazem (Cardizem), felodipine (Plendil), isradipine (DynaCirc), nifedipine (Procardia), and verapamil (Calan, Isoptin); ergot-type medications such as bromocriptine (Parlodel), cabergoline, dihydroergotamine (D. H.E. 45, Migranal), ergoloid mesylates (Hydergine), ergonovine (Ergotrate), ergotamine (Cafergot), methylergonovine (Methergine), methysergide (Sansert), and pergolide (Permax); medications for high blood pressure, heart failure, or an irregular heartbeat. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

you should know that nitroglycerin sublingual tablets may not dissolve easily in your mouth if you are taking medications that cause dry mouth such as antihistamines; antidepressants including amitriptyline (Elavil), amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Adapin, Sinequan), imipramine (Tofranil), nortriptyline (Aventyl, Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil); ipratropium (Atrovent); or medications for irritable bowel disease, motion sickness, Parkinson's disease, ulcers, or urinary problems. If this happens, use an artificial saliva product or chew gum to increase the amount of saliva in your mouth so that the tablet will dissolve.

tell your doctor if you have recently had a heart attack and if you have anemia (low number of red blood cells) or any condition that causes increased pressure in your skull. Your doctor may tell you not to take nitroglycerin.

tell your doctor if you think you may be dehydrated and if you have or have ever had heart failure, low blood pressure, or hypertrophic cardiomyopathy (thickening of the heart muscles).

tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking nitroglycerin, call your doctor.

if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking nitroglycerin.

ask your doctor about the safe use of alcoholic beverages while you are taking nitroglycerin. Alcohol can make the side effects from nitroglycerin worse.

you should know that nitroglycerin may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position, or at any time, especially if you have been drinking alcoholic beverages. To avoid this problem, get up slowly, resting your feet on the floor for a few minutes before standing up. Take extra precautions to avoid falling during your treatment with nitroglycerin.

you should know that you may experience headaches during your treatment with nitroglycerin. These headaches may be a sign that the medication is working as it should. Do not try to change the times that you take nitroglycerin in order to avoid headaches because then the medication may not work as well.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I do if I forget a dose?

Nitroglycerin sublingual tablets are usually taken as needed to treat episodes of angina; do not take them on a regular basis.

What side effects can this medication cause?

Nitroglycerin may cause side effects. Tell your doctor if any of these symptoms or those listed in SPECIAL PRECAUTIONS section are severe or do not go away:

Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:

blurred vision

dry mouth

worsening chest pain

rash, blistering, or peeling of the skin

hives

itching

difficulty breathing or swallowing

nausea

vomiting

weakness

sweating

pale skin

Nitroglycerin sublingual may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www. fda. gov/Safety/MedWatch ) or by phone (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo. gl/c4Rm4p ) for more information if you do not have access to a take-back program.

In case of emergency/overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Symptoms of overdose may include the following:

headache

confusion

fever

dizziness

slow or pounding heartbeat

nausea

vomiting

bloody diarrhea

fainting

shortness of breath

sweating

flushing

cold, clammy skin

loss of ability to move the body

coma (loss of consciousness for a period of time)

seizures

What other information should I know?

Keep all appointments with your doctor

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

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Baclofen Oral Uses, Side Effects, Interactions, Pictures, Warnings - Dosing, Baclosan

baclofen

Uses

Baclofen is used to treat muscle spasms caused by certain conditions (such as multiple sclerosis. spinal cord injury/disease). It works by helping to relax the muscles.

How to use baclofen

Take this medication by mouth with or without food as directed by your doctor, usually 3 times a day. To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's instructions carefully.

The dosage is based on your medical condition and response to treatment. Do not increase your dose or take it more often than prescribed.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day. Do not stop taking this medication without consulting your doctor. Some conditions may become worse when this drug is suddenly stopped. Also, you may experience withdrawal symptoms such as hallucinations and seizures. To prevent withdrawal reactions, your doctor may reduce your dose gradually. Consult your doctor or pharmacist for more details, and report any withdrawal reactions right away.

Tell your doctor if your condition does not improve or if it worsens.

Side Effects

Drowsiness, dizziness. weakness. tiredness, headache. trouble sleeping. nausea. increased urination, or constipation may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: mental/mood changes (such as confusion, depression. hallucinations).

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction. including: rash. itching /swelling (especially of the face/tongue /throat), severe dizziness, trouble breathing .

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking baclofen, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease. mental/mood disorders (such as schizophrenia ), brain disorders (such as seizures, stroke ).

This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Avoid alcoholic beverages.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Older adults may be more sensitive to the side effects of this drug, especially drowsiness and mental/mood changes (such as confusion).

During pregnancy. this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

This drug passes into breast milk. Consult your doctor before breast - feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Tell your doctor or pharmacist if you are taking other products that cause drowsiness including alcohol, antihistamines (such as cetirizine. diphenhydramine ), drugs for sleep or anxiety (such as alprazolam. diazepam. zolpidem), other muscle relaxants, and narcotic pain relievers (such as codeine).

Check the labels on all your medicines (such as allergy or cough - and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.

Overdose

If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: vomiting. severe drowsiness, slow/shallow breathing, seizures.

Notes

Do not share this medication with others.

This medication has been prescribed for your current condition only. Do not use it later for another condition unless your doctor directs you to do so. A different medication may be necessary in that case.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Information last revised March 2016. Copyright(c) 2016 First Databank, Inc.

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Amoxypen, Amoxypen

amoxicillin

amoxicillin

an antibiotic that is a penicillin analogue similar in action to ampicillin but more efficiently absorbed from the gastrointestinal tract and therefore requiring less frequent dosage and not as likely to cause diarrhea.

a·mox·i·cil·lin

A semisynthetic penicillin antibiotic with an antimicrobial spectrum similar to that of ampicillin.

amoxicillin

/amox·i·cil·lin/ ( ah-mok″sĭ-sil?in ) a semisynthetic derivative of ampicillin effective against a broad spectrum of gram-positive and gram-negative bacteria.

amoxicillin

A semisynthetic penicillin, C 16 H 19 N 3 O 5 S, having an antibacterial spectrum of action similar to that of ampicillin.

amoxicillin

a beta-lactam semisynthetic oral penicillin antibiotic.

indication It is prescribed in the treatment of infections caused by a susceptible gram-negative or gram-positive bacteria.

contraindication Known hypersensitivity to any penicillin prohibits its use.

adverse effects Among the most serious adverse reactions are anaphylaxis, nausea, and diarrhea. Allergic reactions and rashes are common.

amoxicillin

Infectious disease A broad-spectrum semisynthetic penicillin with activity similar to that of ampicillin

amoxicillin

Amoxycillin, an AMPICILLIN - like penicillin antibiotic, effective in TYPHOID and many other infections. Brand names are Amoxil and Galenamox. Compounded with lansoprazol and clarithromycin it is marketed as Heliclear.

amoxicillin

penicillin antibiotic of similar action to ampicillin; usually administered as 250 mg by mouth every 8 hours (125 mg every 8 hours for a child) for soft-tissue infections

a·mox·i·cil·lin

A semisynthetic penicillin antibiotic with an antimicrobial spectrum similar to that of ampicillin.

amoxicillin, amoxycillin

an aminopenicillin, similar in action to ampicillin and susceptible to β-lactamase, but more efficiently absorbed from the gastrointestinal tract and with a longer duration of action.

addition of clavulanic acid widens the spectrum of activity and renders amoxicillin resistant to β-lactamase. A widely used antibiotic in dogs and cats.

Link to this page:

amoxicillin

amoxicillin

an antibiotic that is a penicillin analogue similar in action to ampicillin but more efficiently absorbed from the gastrointestinal tract and therefore requiring less frequent dosage and not as likely to cause diarrhea.

a·mox·i·cil·lin

A semisynthetic penicillin antibiotic with an antimicrobial spectrum similar to that of ampicillin.

amoxicillin

/amox·i·cil·lin/ ( ah-mok″sĭ-sil?in ) a semisynthetic derivative of ampicillin effective against a broad spectrum of gram-positive and gram-negative bacteria.

amoxicillin

A semisynthetic penicillin, C 16 H 19 N 3 O 5 S, having an antibacterial spectrum of action similar to that of ampicillin.

amoxicillin

a beta-lactam semisynthetic oral penicillin antibiotic.

indication It is prescribed in the treatment of infections caused by a susceptible gram-negative or gram-positive bacteria.

contraindication Known hypersensitivity to any penicillin prohibits its use.

adverse effects Among the most serious adverse reactions are anaphylaxis, nausea, and diarrhea. Allergic reactions and rashes are common.

amoxicillin

Infectious disease A broad-spectrum semisynthetic penicillin with activity similar to that of ampicillin

amoxicillin

Amoxycillin, an AMPICILLIN - like penicillin antibiotic, effective in TYPHOID and many other infections. Brand names are Amoxil and Galenamox. Compounded with lansoprazol and clarithromycin it is marketed as Heliclear.

amoxicillin

penicillin antibiotic of similar action to ampicillin; usually administered as 250 mg by mouth every 8 hours (125 mg every 8 hours for a child) for soft-tissue infections

a·mox·i·cil·lin

A semisynthetic penicillin antibiotic with an antimicrobial spectrum similar to that of ampicillin.

amoxicillin, amoxycillin

an aminopenicillin, similar in action to ampicillin and susceptible to β-lactamase, but more efficiently absorbed from the gastrointestinal tract and with a longer duration of action.

addition of clavulanic acid widens the spectrum of activity and renders amoxicillin resistant to β-lactamase. A widely used antibiotic in dogs and cats.

Link to this page:



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Cetraxal (Ciprofloxacin Otic Solution) Side Effects, Interactions, Warning, Dosage & Uses, Cetraxal

DRUG DESCRIPTION

CETRAXAL (ciprofloxacin otic solution) 0.2% contains the synthetic antimicrobial agent ciprofloxacin hydrochloride. CETRAXAL (ciprofloxacin otic solution) is a sterile, preservative-free solution for otic use. Each single use container of CETRAXAL delivers 0.25 mL of solution equivalent to 0.5 mg of ciprofloxacin. The inactive ingredients are povidone, glycerin, and water for injection. Sodium hydroxide and/or lactic acid may be added to adjust pH.

Ciprofloxacin, a fluroquinolone is available as the monohydrochloride, monohydrate salt of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid. Its molecular formula is C 17 H 18 FN 3 O 3 •HCl•H 2 O, and molecular weight is 385.82.

The chemical structure of ciprofloxacin hydrochloride is:

What are the possible side effects of ciprofloxacin otic (Cetraxal)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have a serious side effect such as:

the first sign of any skin rash, no matter how mild;

white patches in your mouth or throat; or

vaginal itching or discharge.

Less serious side effects may include:

headache; or

itching, pain, or mild irritation after using the ear drops.

What are the precautions when taking ciprofloxacin otic solution (Cetraxal)?

Before using this medication, tell your doctor or pharmacist if you are allergic to it or to other quinolone antibiotics (such as ofloxacin, levofloxacin), or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history.

This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor.

It is not known whether ciprofloxacin in this ear drop passes into breast milk and the effect on a nursing infant is unknown. Discuss the risks and benefits with your doctor before.

Last reviewed on RxList: 5/26/2009 This monograph has been modified to include the generic and brand name in many instances.



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Nizoral wird zur Behandlung von Pilzinfektionen verschrieben. Nizoral ist ein Azol-Antimykotika. Es totet empfindlichen Pilzen und stort die Bildung der Zellmembran des Pilzes.

Verwenden Sie Nizoral wie von Ihrem Arzt verordnet!

Nehmen Nizoral durch den Mund mit oder ohne Nahrung.

Nehmen Sie keine Antazida innerhalb von 1 Stunde vor oder 2 Stunden nach Nizoral nehmen.

Wenn Sie auch mit ein Anticholinergikum (zB, Hyoscyamin), einen H 2-Antagonisten (zB Famotidin) oder einen Protonenpumpeninhibitor (zB Omeprazol), nehmen Nizoral mindestens 2 Stunden vor dem H 2-Antagonisten, Protonenpumpen-Hemmer, oder anticholinergen.

Zur Klarung Ihrer Infektion vollstandig nehmen Nizoral fur das gesamte Verlauf der Behandlung. Halten Sie dabei, selbst wenn Sie sich besser in ein paar Tagen zu spuren.

Nizoral funktioniert am besten, wenn sie zur gleichen Zeit jeden Tag genommen wird.

Wenn Sie eine Dosis von Nizoral, bringen Sie es so bald wie moglich. Wenn es fast Zeit fur Ihre nachste Dosis ist, uberspringen Sie die vergessene Dosis und gehen Sie zuruck zu Ihrem regelma?igen Dosierungsschema. Nehmen Sie nicht 2 Dosen auf einmal.

Fragen Sie Ihren Arzt Fragen konnen Sie sich uber die Verwendung von Nizoral haben kann.

Shop Nizoral zwischen 59 und 77 Grad F (15 und 25 Grad C). Lager weg von der Hitze, Feuchtigkeit und Licht. Nicht im Bad. Halten Sie Nizoral au?erhalb der Reichweite von Kindern und weg von Haustieren.

Verwenden Sie KEINE Nizoral, wenn:

Sie sind allergisch gegen jegliche Zutaten in Nizoral

Sie haben eine Pilzinfektion im Gehirn Membranen (Pilzmeningitis)

Sie nehmen ein Aldosteron-Blocker (zB Eplerenon), Astemizol, Cisaprid, conivaptan, Dofetilid, ein Mutterkornalkaloid (zB Ergotamin), Erythromycin, Midazolam, Nevirapin, Pimozid, ein Chinazolin (zB Alfuzosin), Chinidin, Rifabutin, Rifampicin. Terfenadin, Triazolam, oder ein 5-HT-Rezeptor-Agonisten (z. B. Eletriptan).

Fragen Sie Ihren Arzt oder Ihre Arztin sofort, wenn einer dieser Punkte auf Sie zutreffen.

Einige medizinische Bedingungen konnen mit Nizoral interagieren. Informieren Sie Ihren Arzt oder Apotheker, wenn Sie irgendwelche medizinischen Bedingungen haben, vor allem, wenn einer der folgenden Punkte auf Sie zutrifft:

wenn Sie schwanger sind, planen, schwanger zu werden, oder stillen

wenn Sie verschreibungspflichtige oder nicht verschreibungspflichtige Arzneimittel, pflanzliche Zubereitung oder Nahrungserganzungsmittel

wenn Sie Allergien gegen Medikamente, Nahrungsmittel oder andere Substanzen,

wenn Sie allergisch auf andere Azol-Antimykotika (zB Itraconazol)

wenn Sie einen niedrigen Magensaure (zB hypochlorhydria)

wenn Sie eine Lebererkrankung, regelma?ige Alkoholkonsum, Alkoholmissbrauch oder-abhangigkeit, oder Blut Probleme (zB prophyria).

Einige Arzneimittel konnen mit Nizoral interagieren. Informieren Sie Ihren Arzt, wenn Sie andere Arzneimittel einnehmen, vor allem einer der folgenden Eigenschaften sind:

Viele verschreibungspflichtigen und rezeptfreien Medikamente (zB verwendet fur Infektionen, HIV, Krampfanfalle, Angst, Schlafstorungen, Sodbrennen, Diabetes, hoher Cholesterinspiegel, Herzerkrankungen, Bluthochdruck, Allergien, unregelma?iger Herzschlag, Schmerzen, Blutverdunnung, Asthma, Migrane, Stimmung oder psychische Probleme, Krebs, Prostata-Probleme, Schwachung des Immunsystems, erektile Dysfunktion, Harn-Probleme, oder Empfangnisverhutung [Geburtenkontrolle]), Multivitamin-Produkte und Krauter oder Nahrungserganzungsmittel konnen mit Nizoral interagieren, wodurch das Risiko von schweren Nebenwirkungen

Nevirapin, Rifabutin oder Rifampicin, weil sie verringern kann Nizoral die Wirksamkeit

Astemizol, Cisaprid, Dofetilid, Erythromycin, Pimozid, Chinidin, Terfenadin oder weil das Risiko von schweren Herz-Wirkung kann erhoht werden

Midazolam oder Triazolam, weil ihre Aktionen und das Risiko ihrer Nebenwirkungen durch Nizoral erhoht werden kann, was zu einem erhohten Risiko der Sedierung und Atembeschwerden

Aldosteron-Blocker (zB Eplerenon), Conivaptan, Mutterkorn-Alkaloide (zB Ergotamin), Chinazolinen (zB Alfuzosin) oder 5-HT-Rezeptor-Agonisten (zB Eletriptan), weil das Risiko der Nebenwirkungen konnen durch Nizoral erhoht werden.

Dies kann nicht eine vollstandige Liste aller Interaktionen, die auftreten konnen. Fragen Sie Ihren Arzt, wenn Nizoral mit anderen Medikamenten, die Sie einnehmen. Prufen Sie mit Ihrem Arzt, bevor Sie starten, stoppen, oder andern Sie die Dosis einer Medizin.

Wichtige Sicherheitshinweise:

Nizoral kann Schwindel oder Benommenheit. Diese Auswirkungen konnen noch schlimmer, wenn Sie es mit Alkohol oder bestimmte Medikamente. Verwenden Sie Nizoral mit Vorsicht. Nicht Auto fahren oder andere moglicherweise unsichere Aufgaben, bis Sie, wie Sie darauf reagieren.

In seltenen Fallen kann Nizoral verursachen eine schwere allergische Reaktion direkt nach der ersten Dosis zu nehmen. Symptome konnen Atemnot, Engegefuhl in der Brust, Schwellungen der Augenlider, des Gesichts, Lippen oder Hautausschlag oder Nesselsucht. Wenn dies geschieht, arztlichen Versorgung auf einmal.

Verwendung von Alkohol mit Nizoral selten verursacht Symptome wie Rotungen, Hautausschlag, Schwellung der Hande und Fu?e, Ubelkeit und Kopfschmerzen. Sprechen Sie mit Ihrem Arzt, bevor Sie Alkohol trinken, wahrend der Einnahme von Nizoral.

Nehmen Sie nicht mehr als die empfohlene Dosis oder Verwendung langer als ohne Rucksprache mit Ihrem Arzt verordnet.

Nizoral funktioniert nur gegen Pilze, es nicht zu behandeln virale Infektionen (zB eine Erkaltung) oder bakterielle Infektionen.

Verwenden Sie unbedingt fur die gesamte Verlauf der Behandlung Nizoral. Wenn Sie das nicht tun, kann die Medizin nicht klar, bis Ihre Infektion vollstandig. Die Infektion konnten auch weniger anfallig fur diese oder andere Arzneimittel. Dies konnte die Infektion schwerer zu behandeln in der Zukunft.

Diabetes-Patienten - Nizoral kann das Risiko eines zu niedrigen Blutzuckerspiegels von Ihrem Diabetes-Medikament. Check Blutzucker eng. Fragen Sie Ihren Arzt, bevor Sie die Dosis Ihres Diabetes Medizin zu andern.

Hormonelle Empfangnisverhutung (zB Pille) moglicherweise nicht so gut arbeiten, wahrend Sie mit Nizoral sind. Um eine Schwangerschaft zu verhindern, verwenden Sie eine zusatzliche Form der Empfangnisverhutung (zB Kondome).

Lab-Tests, einschlie?lich Leberwerte, kann durchgefuhrt werden, wahrend Sie Nizoral verwenden. Diese Tests konnen verwendet werden, um Ihren Zustand zu uberprufen oder auf Nebenwirkungen zu uberwachen. Achten Sie darauf, alle Arzt-und Labor-Terminen.

Nizoral sollte mit au?erster Vorsicht bei Kindern angewendet werden, Sicherheit und Wirksamkeit bei Kindern wurden nicht bestatigt.

Schwangerschaft und Stillzeit: Wenn Sie schwanger werden, wenden Sie sich an Ihren Arzt. Sie mussen die Vorteile und Risiken der Verwendung von Nizoral zu diskutieren, wahrend Sie schwanger sind. Nizoral ist in der Muttermilch gefunden. Nicht stillen, wahrend Sie Nizoral.



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Cipronax, Cipronax

Ciprofloxacin

Antibacterial: Fluoroquinolone (gyrase inhibitor)

Chemical Name

3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-

Foreign Names

Generic Names

Ciprofloxacin (OS: BAN, USAN, JAN)

Ciprofloxacine (OS: DCF)

Bay q 3939 (IS)

Ciprofloxacin Betaine (IS)

Ciprofloxacin (PH: BP 2016, Ph. Eur. 8, Ph. Int. 4, USP 38)

Ciprofloxacine (PH: Ph. Eur. 8)

Ciprofloxacinum (PH: Ph. Eur. 8, Ph. Int. 4)

Ciprofloxacin Hydrochloride (OS: USAN, BANM, JAN)

Bay o 9867 monohydrate (IS: Bayer)

UNII-4BA73M5E37 (IS)

Ciprofloxacin Hydrochloride (PH: BP 2016, Ph. Int. 4, USP 38)

Ciprofloxacin hydrochloride (PH: Ph. Eur. 8)

Ciprofloxacine (chlorhydrate de) (PH: Ph. Eur. 8)

Ciprofloxacinhydrochlorid (PH: Ph. Eur. 8)

Ciprofloxacini hydrochloridum (PH: Ph. Eur. 8, Ph. Int. 4)

Ciprofloxacin sulfate (IS)

Ciprofloxacin Lactate (OS: BANM)

Brand Names

Click for further information on drug naming conventions and International Nonproprietary Names .

Important Notice: The Drugs. com international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

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Ciplox is used to treat different types of bacterial infections. It may also be used to prevent or slow anthrax after exposure.

Take Cipro exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Take Cipro with a full glass of water (8 ounces). Drink several extra glasses of fluid each day while you are taking this medicine. Cipro may be taken with or without food, but take it at the same time each day. Shake the oral suspension (liquid) for at least 15 seconds just before you measure a dose. To be sure you get the correct dose, measure the liquid with a marked measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

When taking the Cipro oral liquid, swallow it without chewing the medicine beads you may notice in the liquid.

Do not crush, chew, or break an extended-release tablet. Swallow it whole. Breaking the pill may cause too much of the drug to be released at one time. Do not take Cipro with dairy products such as milk or yogurt, or with calcium-fortified juice. You may eat or drink these products as part of a regular meal, but do not use them alone when taking Cipro. They could make the medication less effective.

Take Cipro for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Cipro will not treat a viral infection such as the common cold or flu.

Store Cipro at room temperature away from moisture and heat. Do not allow the liquid medicine to freeze.

If you missed a dose - take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Take exactly as prescribed by your Health Provider.

Store this medicine at room temperature away from moisture and heat. Do not allow the liquid medicine to freeze.

You should not use Ciplox if you are taking tizanidine (Zanaflex), if you have a history of myasthenia gravis, or if you are allergic to ciprofloxacin or similar antibiotics such as gemifloxacin (Factive), levofloxacin (Levaquin), moxifloxacin (Avelox), norfloxacin (Noroxin), and others.

Before taking Ciplox, tell your doctor if you have a heart rhythm disorder, kidney or liver disease, joint problems, diabetes, muscle weakness or trouble breathing, a condition called pseudotumor cerebri, a history of seizures, a history of head injury or brain tumor, low levels of potassium in your blood, a personal or family history of Long QT syndrome, or if you have ever had an allergic reaction to an antibiotic.

Do not take Ciplox with dairy products such as milk or yogurt, or with calcium-fortified juice. Avoid taking antacids, vitamin or mineral supplements, sucralfate (Carafate), or didanosine (Videx) powder or chewable tablets within 6 hours before or 2 hours after you take Ciplox. Ciprofloxacin may cause swelling or tearing of a tendon (the fiber that connects bones to muscles in the body), especially in the Achilles' tendon of the heel. Stop taking Ciplox and call your doctor at once if you have sudden pain, swelling, tenderness, stiffness, or movement problems in any of your joints. Rest the joint until you receive medical care or instructions.

You should NOT take Ciplox if:

you are also taking tizanidine (Zanaflex);

you have a history of myasthenia gravis; or

you are allergic to ciprofloxacin or similar medications such as gemifloxacin (Factive), levofloxacin (Levaquin), moxifloxacin (Avelox), ofloxacin (Floxin), norfloxacin (Noroxin), and others.

To make sure you can safely take Ciplox, tell your doctor if you have any of these other conditions:

heart rhythm disorder, especially if you take quinidine (Quin-G), disopyramide (Norpace), bretylium (Bretylol), procainamide (Pronestyl, Procan SR), amiodarone (Cordarone, Pacerone), or sotalol (Betapace);

a history of head injury or brain tumor;

a condition called pseudotumor cerebri (high pressure inside the skull that may cause headaches, vision loss, or other symptoms);

a history of allergic reaction to an antibiotic;

joint problems;

kidney or liver disease;

epilepsy or seizures;

diabetes;

muscle weakness or trouble breathing;

low levels of potassium in your blood (hypokalemia); or

a personal or family history of Long QT syndrome.

FDA pregnancy category C. It is not known whether Ciplox will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using it. Ciprofloxacin passes into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Ciplox may cause swelling or tearing of a tendon (the fiber that connects bones to muscles in the body), especially in the Achilles' tendon of the heel. These effects may be more likely to occur if you are over 60, if you take steroid medication, or if you have had a kidney, heart, or lung transplant. Stop taking Ciplox and call your doctor at once if you have sudden pain, swelling, tenderness, stiffness, or movement problems in any of your joints. Rest the joint until you receive medical care or instructions. Do not share Ciplox with another person (especially a child), even if they have the same symptoms you have.

Get emergency medical help if you have any of these signs of an allergic reaction to Ciplox: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using Ciplox and call your doctor at once if you have a serious side effect such as:

severe dizziness, fainting, fast or pounding heartbeats;

sudden pain, snapping or popping sound, bruising, swelling, tenderness, stiffness, or loss of movement in any of your joints;

diarrhea that is watery or bloody;

confusion, hallucinations, depression, unusual thoughts or behavior;

seizure (convulsions);

severe headache, ringing in your ears, dizziness, nausea, vision problems, pain behind your eyes;

pale or yellowed skin, dark colored urine, fever, weakness;

urinating less than usual or not at all;

easy bruising or bleeding;

numbness, tingling, or unusual pain anywhere in your body;

the first sign of any skin rash, no matter how mild; or

severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Less serious side effects:

nausea, vomiting;

dizziness or drowsiness;

blurred vision;

feeling nervous, anxious, or agitated; or

sleep problems (insomnia or nightmares).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.



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Pantoprazole Oral Uses, Side Effects, Interactions, Pictures, Warnings - Dosing, Panprozole

pantoprazole

GENERIC NAME(S): PANTOPRAZOLE SODIUM

Uses

Pantoprazole is used to treat certain stomach and esophagus problems (such as acid reflux ). It works by decreasing the amount of acid your stomach makes. This medication relieves symptoms such as heartburn. difficulty swallowing, and persistent cough. It helps heal acid damage to the stomach and esophagus, helps prevent ulcers, and may help prevent cancer of the esophagus. Pantoprazole belongs to a class of drugs known as proton pump inhibitors (PPIs).

OTHER USES: This section contains uses of this drug that are not listed in the approved US professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.

This medication may also be used to treat and prevent stomach and intestinal ulcers.

How to use pantoprazole

Read the Medication Guide provided by your pharmacist before you start taking pantoprazole and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth as directed by your doctor, usually once daily. Dosage and length of treatment are based on your medical condition and response to treatment.

If you are taking the tablets, you may take them with or without food. Swallow the tablets whole. Do not split, crush, or chew the medication. Doing so may destroy the drug.

If you are taking the granules, take your dose 30 minutes before a meal. To take it by mouth. open the packet and mix the granules in applesauce or apple juice. Do not mix with other foods or liquids. Do not crush or chew the granules. Sprinkle the granules on 1 teaspoon (5 milliliters) of applesauce and swallow all of the mixture right away (within 10 minutes). Follow with sips of water. Or you can mix the granules with 1 teaspoon (5 milliliters) of apple juice in a small cup, stir for 5 seconds, and swallow all of the mixture right away. To make sure you take the entire dose, rinse the cup once or twice with apple juice to mix any remaining granules, and swallow the juice. Do not prepare the mixture ahead of time for later use.

If you are giving the granules through a tube into the stomach (nasogastric or gastric tube), ask your health care professional for detailed instructions on how to properly mix and give it.

If needed, antacids may be taken along with this medication. If you are also taking sucralfate, take pantoprazole at least 30 minutes before sucralfate.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. Continue to take this medication for the prescribed length of treatment even if you are feeling better.

Tell your doctor if your condition persists or worsens.

Side Effects

Headache or diarrhea may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: symptoms of a low magnesium blood level (such as unusually fast/slow/irregular heartbeat. persistent muscle spasms. seizures ).

This medication may rarely cause a severe intestinal condition (Clostridium difficile - associated diarrhea) due to a type of bacteria. Do not use anti-diarrhea products or narcotic pain medications if you have any of the following symptoms because these products may make them worse. Tell your doctor right away if you develop: persistent diarrhea, abdominal or stomach pain /cramping, fever, blood /mucus in your stool.

Rarely, proton pump inhibitors (such as pantoprazole) have caused vitamin B-12 deficiency. The risk is increased if they are taken every day for a long time (3 years or longer). Tell your doctor right away if you develop symptoms of vitamin B-12 deficiency (such as unusual weakness. sore tongue. or numbness/tingling of the hands/feet).

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction. including: rash. itching /swelling (especially of the face/tongue /throat), severe dizziness. trouble breathing. kidney problems (such as change in the amount of urine).

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking pantoprazole, tell your doctor or pharmacist if you are allergic to it; or to similar drugs (such as lansoprazole. omeprazole ); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease.

Some symptoms may actually be signs of a more serious condition. Get medical help right away if you have: heartburn with lightheadedness/sweating /dizziness, chest/jaw/arm/shoulder pain (especially with shortness of breath, unusual sweating ), unexplained weight loss .

Proton pump inhibitors (such as pantoprazole) may increase your risk for bone fractures. especially with longer use, higher doses, and in older adults. Talk with your doctor or pharmacist about ways to prevent bone loss /fracture, such as by taking calcium (such as calcium citrate ) and vitamin D supplements .

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

This medication passes into breast milk. Consult your doctor before breast-feeding.

Interactions

See also How to Use section.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

A product that may interact with this drug is: methotrexate (especially high-dose treatment).

Some products need stomach acid so that the body can absorb them properly. Pantoprazole decreases stomach acid, so it may change how well these products work. Some affected products include ampicillin, atazanavir, erlotinib, nelfinavir, pazopanib, rilpivirine, certain azole antifungals (itraconazole, ketoconazole, posaconazole), among others.

This medication may interfere with certain laboratory tests (including urine test for tetrahydrocannabinol-THC), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

Overdose

If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Notes

Do not share this medication with others.

If your doctor instructs you to use this medication regularly for a long time, laboratory and medical tests (such as a magnesium blood test, vitamin B-12 levels) may be performed periodically to monitor your progress or check for side effects. Keep all regular medical and laboratory appointments.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Information last revised October 2015. Copyright(c) 2015 First Databank, Inc.

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Contiflo Xl Capsules 400 Micrograms, Contiflo

Details

Tamsulosin is used to treat symptoms of an enlarged prostate gland in men. This enlargement of the prostate gland is called Benign Prostate Hypertrophy (BPH). The enlarged prostate gland may cause problems when you pass urine. Tamsulosin relaxes the muscles in the prostate gland and bladder. This helps to improve symptoms such as difficulty in passing urine, slow or interrupted flow of urine, frequent urination and dribbling after passing urine.

Directions

How do I take this medicine? Take Tamsulosin exactly as directed by your doctor. Do not take more or less than instructed by your doctor.

Take Tamsulosin 30 minutes after a meal. Try to take it at the same time each day. Swallow Tamsulosin whole with a glass of water. Do not cut, open, crush or chew the capsule or tablet.

Tamsulosin must be taken regularly for it to be effective. Continue taking Tamsulosin even when there are signs of improvement. Do not stop taking Tamsulosin unless instructed by the doctor. What should I do if I have forgotten to take this medicine? Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.

DO NOT double a dose under any circumstances.

If you often forget to take your medicine, let your doctor and pharmacist know. Can I take this with other medicines? Do not take medicines for treatment of erection problems such as sildenafil, tadalafil or vardenafil together with Tamsulosin.

Do not take Tamsulosin if you have taken similar medicines such as doxazosin or prazosin.

Alert your doctor if you are taking any other medicine especially those listed here:

- cimetidine (a gastric medicine) - high blood pressure medicines - fluoxetine (a mood medicine) - ketoconazole (an antifungal medicine)

Always inform your doctor and pharmacist if you are taking any other medicines, including herbal tonics, supplements and medicines that you buy without a prescription. How should I store this medicine? Store in a cool, dry place away from the reach of children.

Medicines must not be used past the expiry date.

Warnings

When should I not use this medicine? Alert your doctor if you have severe liver disease. Alert your doctor if you or your family members have ever had prostate cancer.

Do not take Tamsulosin if you have ever fainted or felt dizzy when getting up from a sitting or lying down position. What should I take note of while taking this medicine? Inform your doctor if you have kidney or liver disease, chest pain (angina), low blood pressure, allergy to sulphur medicines or any other medical conditions.

If you are going for an operation, including minor surgery, eye or dental operations, inform your doctor, surgeon or dentist that you are taking Tamsulosin. Are there any restrictions on the type of food I can take? Avoid alcohol.

Ingredients

Side Effects

What side effects could I experience? Tamsulosin may cause headache, weakness and ejaculation problems (less or no semen).

You may feel dizzy when getting up from a sitting or lying down position, especially if you are taking Tamsulosin for the first time or if your dose has recently been changed. This is normal and should improve gradually as you get used to the medicine. It will help if you get up slowly from a sitting or lying down position. If you feel dizzy, sit or lie down until you feel better. Do not drive or take part in any activity in which you need to be alert.

If you experience a prolonged, painful erection, alert your doctor and seek medical treatment immediately.

Let your doctor know if any side effects bother you or if they do not go away.

Less commonly, Tamsulosin may cause other side effects. Alert your doctor if you experience any unusual problems while being treated with Tamsulosin.



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Ofloxacin - Fda Prescribing Information, Side Effects And Uses, Oxacin

Ofloxacin

WARNING: SERIOUS ADVERSE REACTIONS INCLUDING TENDINITIS, TENDON RUPTURE, PERIPHERAL NEUROPATHY, CENTRAL NERVOUS SYSTEM EFFECTS AND EXACERBATION OF MYASTHENIA GRAVIS

Fluoroquinolones, including Ofloxacin, have been associated with disabling and potentially irreversible serious adverse reactions that have occurred together, including:

Tendinitis and tendon rupture

Peripheral neuropathy

Central nervous system effects (see WARNINGS )

Discontinue Ofloxacin immediately and avoid the use of fluoroquinolones, including Ofloxacin, in patients who experience any of these serious adverse reactions (see WARNINGS ).

Fluoroquinolones, including Ofloxacin, may exacerbate muscle weakness in persons with myasthenia gravis. Avoid Ofloxacin in patients with known history of myasthenia gravis (see WARNINGS ).

Because fluoroquinolones, including Ofloxacin, have been associated with serious adverse reactions (see WARNINGS ), reserve Ofloxacin for use in patients who have no alternative treatment options for the following indications:

Acute exacerbation of chronic bronchitis

Uncomplicated cystitis (see INDICATIONS AND USAGE )

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Ofloxacin tablets and other antibacterial drugs, Ofloxacin tablets should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.

Ofloxacin Description

Ofloxacin tablets are a synthetic broad-spectrum antimicrobial agent for oral administration. Chemically, Ofloxacin, USP, a fluorinated carboxyquinolone, is the racemate, (±)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7 H - pyrido[1,2,3- de ]-1,4-benzoxazine-6-carboxylic acid. The chemical structure is:

C 18 H 20 FN 3 O 4 MW= 361.4

Ofloxacin, USP is an off-white to pale yellow crystalline powder. The molecule exists as a zwitterion at the pH conditions in the small intestine. The relative solubility characteristics of Ofloxacin, USP at room temperature, as defined by USP nomenclature, indicate that Ofloxacin, USP is considered to be soluble in aqueous solutions with pH between 2 and 5. It is sparingly to slightly soluble in aqueous solutions with pH 7 (solubility falls to 4 mg/mL) and freely soluble in aqueous solutions with pH above 9. Ofloxacin, USP has the potential to form stable coordination compounds with many metal ions. This in vitro chelation potential has the following formation order: Fe +3 > Al +3 > Cu +2 > Ni +2 > Pb +2 > Zn +2 > Mg +2 > Ca +2 > Ba +2 .

INACTIVE INGREDIENTS

Ofloxacin tablets contain the following inactive ingredients: anhydrous lactose, modified corn starch, hydroxypropyl cellulose, hypromellose, magnesium stearate, polyethylene glycol, polysorbate 80, sodium starch glycolate, and titanium dioxide.

Ofloxacin - Clinical Pharmacology

Following oral administration, the bioavailability of Ofloxacin in the tablet formulation is approximately 98%. Maximum serum concentrations are achieved one to two hours after an oral dose. Absorption of Ofloxacin after single or multiple doses of 200 to 400 mg is predictable, and the amount of drug absorbed increases proportionately with the dose. Ofloxacin has biphasic elimination. Following multiple oral doses at steady-state administration, the half-lives are approximately 4 to 5 hours and 20 to 25 hours. However, the longer half-life represents less than 5% of the total AUC. Accumulation at steady-state can be estimated using a half-life of 9 hours. The total clearance and volume of distribution are approximately similar after single or multiple doses. Elimination is mainly by renal excretion. The following are mean peak serum concentrations in healthy 70 to 80 kg male volunteers after single oral doses of 200, 300, or 400 mg of Ofloxacin or after multiple oral doses of 400 mg.

Serum Concentration 2 Hours After Admin. (mcg /mL)

Area Under the Curve (AUC (0-∞) ) (mcg•h/mL)

Steady-state concentrations were attained after four oral doses, and the area under the curve (AUC) was approximately 40% higher than the AUC after single doses. Therefore, after multiple-dose administration of 200 mg and 300 mg doses, peak serum levels of 2.2 mcg/mL and 3.6 mcg/mL, respectively, are predicted at steady-state.

In vitro. approximately 32% of the drug in plasma is protein bound.

The single dose and steady-state plasma profiles of Ofloxacin injection were comparable in extent of exposure (AUC) to those of Ofloxacin tablets when the injectable and tablet formulations of Ofloxacin were administered in equal doses (mg/mg) to the same group of subjects. The mean steady-state AUC (0 to 12) attained after the intravenous administration of 400 mg over 60 min was 43.5 mcg•h/mL; the mean steady-state AUC (0 to 12) attained after the oral administration of 400 mg was 41.2 mcg•h/mL (two one-sided t-test, 90% confidence interval was 103 to 109) (see following chart).

Between 0 and 6 h following the administration of a single 200 mg oral dose of Ofloxacin to 12 healthy volunteers, the average urine Ofloxacin concentration was approximately 220 mcg/mL. Between 12 and 24 hours after administration, the average urine Ofloxacin level was approximately 34 mcg/mL.

Following oral administration of recommended therapeutic doses, Ofloxacin has been detected in blister fluid, cervix, lung tissue, ovary, prostatic fluid, prostatic tissue, skin, and sputum. The mean concentration of Ofloxacin in each of these various body fluids and tissues after one or more doses was 0.8 to 1.5 times the concurrent plasma level. Inadequate data are presently available on the distribution or levels of Ofloxacin in the cerebrospinal fluid or brain tissue.

Ofloxacin has a pyridobenzoxazine ring that appears to decrease the extent of parent compound metabolism. Between 65% and 80% of an administered oral dose of Ofloxacin is excreted unchanged via the kidneys within 48 hours of dosing. Studies indicate that less than 5% of an administered dose is recovered in the urine as the desmethyl or N-oxide metabolites. Four to eight percent of an Ofloxacin dose is excreted in the feces. This indicates a small degree of biliary excretion of Ofloxacin.

The administration of Ofloxacin tablets with food does not affect the C max and AUC ∞ of the drug, but T max is prolonged.

Clearance of Ofloxacin is reduced in patients with impaired renal function (creatinine clearance rate ≤ 50 mL/min), and dosage adjustment is necessary (see PRECAUTIONS, General and DOSAGE AND ADMINISTRATION ).

Following oral administration to healthy elderly subjects (65 to 81 years of age), maximum plasma concentrations are usually achieved one to two hours after single and multiple twice-daily doses, indicating that the rate of oral absorption is unaffected by age or gender. Mean peak plasma concentrations in elderly subjects were 9 to 21% higher than those observed in younger subjects. Gender differences in the pharmacokinetic properties of elderly subjects have been observed. Peak plasma concentrations were 114% and 54% higher in elderly females compared to elderly males following single and multiple twice-daily doses. [This interpretation was based on study results collected from two separate studies.] Plasma concentrations increase dose-dependently with the increase in doses after single oral dose and at steady-state. No differences were observed in the volume of distribution values between elderly and younger subjects. As in younger subjects, elimination is mainly by renal excretion as unchanged drug in elderly subjects, although less drug is recovered from renal excretion in elderly subjects. Consistent with younger subjects, less than 5% of an administered dose was recovered in the urine as the desmethyl and N-oxide metabolites in the elderly. A longer plasma half-life of approximately 6.4 to 7.4 hours was observed in elderly subjects, compared with 4 to 5 hours for young subjects. Slower elimination of Ofloxacin is observed in elderly subjects as compared with younger subjects which may be attributable to the reduced renal function and renal clearance observed in the elderly subjects. Because Ofloxacin is known to be substantially excreted by the kidney, and elderly patients are more likely to have decreased renal function, dosage adjustment is necessary for elderly patients with impaired renal function as recommended for all patients (see PRECAUTIONS, General and DOSAGE AND ADMINISTRATION ).

MICROBIOLOGY

Ofloxacin is a quinolone antimicrobial agent. The mechanism of action of Ofloxacin and other fluoroquinolone antimicrobials involves inhibition of bacterial topoisomerase IV and DNA gyrase (both of which are type II topoisomerases), enzymes required for DNA replication, transcription, repair and recombination.

Ofloxacin has in vitro activity against a wide range of Gram-negative and Gram-positive microorganisms. Ofloxacin is often bactericidal at concentrations equal to or slightly greater than inhibitory concentrations.

Fluoroquinolones, including Ofloxacin, differ in chemical structure and mode of action from aminoglycosides, macrolides and β-lactam antibiotics, including penicillins. Fluoroquinolones may, therefore, be active against bacteria resistant to these antimicrobials.

Resistance to Ofloxacin due to spontaneous mutation in vitro is a rare occurrence (range: 10 -9 to 10 -11 ). Although cross-resistance has been observed between Ofloxacin and some other fluoroquinolones, some microorganisms resistant to other fluoroquinolones may be susceptible to Ofloxacin.

Ofloxacin has been shown to be active against most strains of the following microorganisms both in vitro and in clinical infections as described in the INDICATIONS AND USAGE section:

Aerobic Gram-Positive Microorganisms

Staphylococcus aureus (methicillin-susceptible strains)

Streptococcus pneumoniae (penicillin-susceptible strains)

Aerobic Gram-Negative Microorganisms

Citrobacter (diversus) koseri

As with other drugs in this class, some strains of Pseudomonas aeruginosa may develop resistance fairly rapidly during treatment with Ofloxacin.

The following in vitro data are available, but their clinical significance is unknown.

Ofloxacin exhibits in vitro minimum inhibitory concentrations (MIC values) of 2 mcg/mL or less against most (≥ 90%) strains of the following microorganisms; however, the safety and effectiveness of Ofloxacin in treating clinical infections due to these microorganisms have not been established in adequate and well-controlled trials.

Aerobic Gram-Positive Microorganisms

Staphylococcus epidermidis (methicillin-susceptible strains)

Streptococcus pneumoniae (penicillin-resistant strains)

Aerobic Gram-Negative Microorganisms

Ofloxacin is not active against Treponema pallidum (see WARNINGS ).

Many strains of other streptococcal species, Enterococcus species, and anaerobes are resistant to Ofloxacin.

Quantitative methods are used to determine antimicrobial minimum inhibitory concentrations (MIC values). These MIC values provide estimates of the susceptibility of bacteria to antimicrobial compounds. The MIC values should be determined using a standardized procedure. Standardized procedures are based on a dilution method 1,3 (broth or agar) or equivalent with standardized inoculum concentrations and standardized concentrations of Ofloxacin powder. The MIC values should be interpreted according to the following criteria:

For testing Enterobacteriaceae. methicillin-susceptible Staphylococcus aureus. and Pseudomonas aeruginosa :

For testing Haemophilus influenzae. a

a This interpretive standard is applicable only to broth microdilution susceptibility tests with Haemophilus influenzae using Haemophilus Test Medium. 1,3

The current absence of data on resistant strains precludes defining any results other than “Susceptible.” Strains yielding MIC results suggestive of a “nonsusceptible” category should be submitted to a reference laboratory for further testing.

For testing Neisseria gonorrhoeae. b

b These interpretive standards are applicable only to agar dilution tests using GC agar base and 1% defined growth supplement incubated in 5% CO 2 .

For testing Streptococcus pneumoniae and Streptococcus pyogenes. c

c These interpretive standards are applicable only to broth microdilution susceptibility tests using cation-adjusted Mueller-Hinton broth with 2 to 5% lysed horse blood.

A report of “Susceptible” indicates that the pathogen is likely to be inhibited if the antimicrobial compound in the blood reaches the concentration usually achievable. A report of “Intermediate” indicates that the result should be considered equivocal, and, if the microorganism is not fully susceptible to alternative, clinically feasible drugs, the test should be repeated. This category implies possible clinical applicability in body sites where the drug is physiologically concentrated or in situations where a high dosage of drug can be used. This category also provides a buffer zone which prevents small uncontrolled technical factors from causing major discrepancies in interpretation. A report of “Resistant” indicates that the pathogen is not likely to be inhibited if the antimicrobial compound in the blood reaches the concentration usually achievable; other therapy should be selected.

Standardized susceptibility test procedures require the use of laboratory control microorganisms to control the technical aspects of the laboratory procedures. Standard Ofloxacin powder should provide the following MIC values:

MIC Range (mcg/ mL)

d This quality control range is applicable only to H. influenzae ATCC 49247 tested by a microdilution procedure using Haemophilus Test Medium (HTM). 1,3

e This quality control range is applicable only to N. gonorrhoeae ATCC 49226 tested by an agar dilution procedure using GC agar base with 1% defined growth supplement incubated in 5% CO 2 .

f This quality control range is applicable only to S. pneumoniae ATCC 49619 tested by a microdilution procedure using cation-adjusted Mueller-Hinton broth with 2 to 5% lysed horse blood.

Quantitative methods that require measurement of zone diameters also provide reproducible estimates of the susceptibility of bacteria to antimicrobial compounds. One such standardized procedure 2 requires the use of standardized inoculum concentrations. This procedure uses paper disks impregnated with 5 mcg Ofloxacin to test the susceptibility of microorganisms to Ofloxacin.

Reports from the laboratory providing results of the standard single-disk susceptibility test with a 5 mcg Ofloxacin disk should be interpreted according to the following criteria:

For testing Enterobacteriaceae. methicillin-susceptible Staphylococcus aureus. and Pseudomonas aeruginosa :

Zone Diameter (mm)

j This quality control range is applicable only to H. influenzae ATCC 49247 tested by a disk diffusion procedure using Haemophilus Test Medium (HTM) 2 incubated in 5% CO 2 .

k This quality control range is applicable only to N. gonorrhoeae ATCC 49226 tested by a disk diffusion procedure using GC agar base with 1% defined growth supplement incubated in 5% CO 2 .

l This quality control range is applicable only to S. pneumoniae ATCC 49619 tested by a disk diffusion procedure using Mueller-Hinton agar supplemented with 5% defibrinated sheep blood and incubated in 5% CO 2 .

Indications and Usage for Ofloxacin

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Ofloxacin tablets and other antibacterial drugs, Ofloxacin tablets should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

Ofloxacin tablets are indicated for the treatment of adults with mild to moderate infections (unless otherwise indicated) caused by susceptible strains of the designated microorganisms in the infections listed below. Please see DOSAGE AND ADMINISTRATION for specific recommendations.

Acute Bacterial Exacerbations of Chronic Bronchitis (ABECB) due to Haemophilus influenzae or Streptococcus pneumoniae .

Because fluoroquinolones, including Ofloxacin, have been associated with serious adverse reactions (see WARNINGS ), and for some patients ABECB is self-limiting, reserve Ofloxacin for treatment of ABECB in patients who have no alternative treatment options.

Community-Acquired Pneumonia due to Haemophilus influenzae or Streptococcus pneumoniae.

Uncomplicated Skin and Skin Structure Infections due to methicillin-susceptible Staphylococcus aureus, Streptococcus pyogenes. or Proteus mirabilis .

Acute, Uncomplicated Urethral and Cervical Gonorrhea due to Neisseria gonorrhoeae (see WARNINGS ).

Nongonococcal Urethritis and Cervicitis due to Chlamydia trachomatis (see WARNINGS ).

Mixed Infections of the Urethra and Cervix due to Chlamydia trachomatis and Neisseria gonorrhoeae (see WARNINGS ).

Acute Pelvic Inflammatory Disease (including severe infection) due to Chlamydia trachomatis and/or Neisseria gonorrhoeae (see WARNINGS ).

NOTE: If anaerobic microorganisms are suspected of contributing to the infection, appropriate therapy for anaerobic pathogens should be administered.

Uncomplicated Cystitis due to Citrobacter diversus, Enterobacter aerogenes, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, or Pseudomonas aeruginosa.

Because fluoroquinolones, including Ofloxacin, have been associated with serious adverse reactions (see WARNINGS ), and for some patients uncomplicated cystitis is self-limiting, reserve Ofloxacin for treatment of uncomplicated cystitis in patients who have no alternative treatment options.

Complicated Urinary Tract Infections due to Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Citrobacter diversus, * or Pseudomonas aeruginosa .*

Prostatitis due to Escherichia coli .

* = Although treatment of infections due to this organism in this organ system demonstrated a clinically significant outcome, efficacy was studied in fewer than 10 patients.

Appropriate culture and susceptibility tests should be performed before treatment in order to isolate and identify organisms causing the infection and to determine their susceptibility to Ofloxacin, USP. Therapy with Ofloxacin, USP may be initiated before results of these tests are known; once results become available, appropriate therapy should be continued.

As with other drugs in this class, some strains of Pseudomonas aeruginosa may develop resistance fairly rapidly during treatment with Ofloxacin, USP. Culture and susceptibility testing performed periodically during therapy will provide information not only on the therapeutic effect of the antimicrobial agent but also on the possible emergence of bacterial resistance.

Contraindications

Ofloxacin tablets are contraindicated in persons with a history of hypersensitivity associated with the use of Ofloxacin or any member of the quinolone group of antimicrobial agents.

Warnings

Disabling and Potentially Irreversible Serious Adverse Reactions Including Tendinitis and Tendon Rupture, Peripheral Neuropathy, and Central Nervous System Effects:

Fluoroquinolones, including Ofloxacin, have been associated with disabling and potentially irreversible serious adverse reactions from different body systems that can occur together in the same patient. Commonly seen adverse reactions include tendinitis, tendon rupture, arthralgia, myalgia, peripheral neuropathy, and central nervous system effects (hallucinations, anxiety, depression, insomnia, severe headaches, and confusion). These reactions can occur within hours to weeks after starting Ofloxacin. Patients of any age or without pre-existing risk factors have experienced these adverse reactions (see WARNINGS )

Discontinue Ofloxacin immediately at the first signs or symptoms of any serious adverse reaction. In addition, avoid the use of fluoroquinolones, including Ofloxacin, in patients who have experienced any of these serious adverse reactions associated with fluoroquinolones.

Tendinitis and Tendon Rupture:

Fluoroquinolones, including Ofloxacin, have been associated with an increased risk of tendinitis and tendon rupture in all ages. This adverse reaction most frequently involves the Achilles tendon, and rupture of the Achilles tendon and has been reported with the rotator cuff (the shoulder), the hand, the biceps, the thumb, and other tendons. Tendinitis or tendon rupture can occur within hours or days of starting Ofloxacin, or as long as several months after completion of fluoroquinolone therapy. Tendinitis and tendon rupture can occur bilaterally.

The risk of developing fluoroquinolone-associated tendinitis and tendon rupture is increased in patients over 60 years of age, in those taking corticosteroid drugs, and in patients with kidney, heart or lung transplants. Other factors that may independently increase the risk of tendon rupture include strenuous physical activity, renal failure, and previous tendon disorders such as rheumatoid arthritis. Tendinitis and tendon rupture have been reported in patients taking fluoroquinolones who do not have the above risk factors.

Discontinue Ofloxacin immediately if the patient experiences pain, swelling, inflammation or rupture of a tendon. Avoid fluoroquinolones, including Ofloxacin, in patients who have a history of tendon disorders or have experienced tendinitis or tendon rupture (see ADVERSE REACTIONS ). Patients should be advised to rest at the first sign of tendinitis or tendon rupture, and to contact their healthcare provider regarding changing to a non-quinolone antimicrobial drug.

Peripheral Neuropathy:

Fluoroquinolones, including Ofloxacin, have been associated with an increased risk of peripheral neuropathy. Cases of sensory or sensorimotor axonal polyneuropathy affecting small and/or large axons resulting in paresthesias, hypoesthesias, dysesthesias and weakness have been reported in patients receiving fluoroquinolones, including Ofloxacin. Symptoms may occur soon after initiation of norfloxacin and may be irreversible in some patients (see WARNINGS ).

Discontinue Ofloxacin immediately if the patient experiences symptoms of peripheral neuropathy including pain, burning, tingling, numbness, and/or weakness, or other alterations in sensations including light touch, pain, temperature, position sense and vibratory sensation, and/or motor strength in order to minimize the development of an irreversible condition. Avoid fluoroquinolones, including Ofloxacin, in patients who have previously experienced peripheral neuropathy (see ADVERSE REACTIONS ).

Central Nervous System Effects:

Fluoroquinolones, including Ofloxacin, have been associated with an increased risk of central nervous system (CNS) effects, including convulsions, increased intracranial pressure (including pseudotumor cerebri), and toxic psychoses. Quinolones may also cause central nervous system (CNS) stimulation which may lead to tremors, restlessness, lightheadedness, confusion, and hallucinations. If these reactions occur in patients receiving Ofloxacin, the drug should be discontinued and appropriate measures instituted.

The effects of Ofloxacin on brain function or on the electrical activity of the brain have not been tested. Therefore, until more information becomes available, Ofloxacin, like all other quinolones, should be used with caution in patients with known or suspected CNS disorders, such as severe cerebral arteriosclerosis, epilepsy, and other factors which predispose to seizures (see ADVERSE REACTIONS ).

Exacerbation of Myasthenia Gravis:

Fluoroquinolones, including Ofloxacin, have neuromuscular blocking activity and may exacerbate muscle weakness in persons with myasthenia gravis. Postmarketing serious adverse events, including deaths and requirement for ventilatory support, have been associated with fluoroquinolone use in persons with myasthenia gravis. Avoid Ofloxacin in patients with known history of myasthenia gravis (see PRECAUTIONS, Information for Patients. and ADVERSE REACTIONS, Postmarketing Adverse Events ).

THE SAFETY AND EFFICACY OF Ofloxacin IN PEDIATRIC PATIENTS AND ADOLESCENTS (UNDER THE AGE OF 18 YEARS), PREGNANT WOMEN, AND LACTATING WOMEN HAVE NOT BEEN ESTABLISHED (see PRECAUTIONS, Pediatric Use. Pregnancy. and Nursing Mothers Subsections).

In the immature rat, the oral administration of Ofloxacin at 5 to 16 times the recommended maximum human dose based on mg/kg or 1 to 3 times based on mg/m 2 increased the incidence and severity of osteochondrosis. The lesions did not regress after 13 weeks of drug withdrawal.

Other quinolones also produce similar erosions in the weight-bearing joints and other signs of arthropathy in immature animals of various species (see ANIMAL PHARMACOLOGY ).

Hypersensitivity Reactions:

Serious and occasionally fatal hypersensitivity and/or anaphylactic reactions have been reported in patients receiving therapy with quinolones, including Ofloxacin. These reactions often occur following the first dose. Some reactions have been accompanied by cardiovascular collapse, hypotension/shock, seizure, loss of consciousness, tingling, angioedema (including tongue, laryngeal, throat, or facial edema/swelling), airway obstruction (including bronchospasm, shortness of breath, and acute respiratory distress), dyspnea, urticaria, itching, and other serious skin reactions. This drug should be discontinued immediately at the first appearance of a skin rash or any other sign of hypersensitivity. Serious acute hypersensitivity reactions may require treatment with epinephrine and other resuscitative measures, including oxygen, intravenous fluids, antihistamines, corticosteroids, pressor amines, and airway management, as clinically indicated (see PRECAUTIONS and ADVERSE REACTIONS ).

Other serious and sometimes fatal events, some due to hypersensitivity, and some due to uncertain etiology, have been reported rarely in patients receiving therapy with quinolones, including Ofloxacin. These events may be severe and generally occur following the administration of multiple doses. Clinical manifestations may include one or more of the following:

fever, rash, or severe dermatologic reactions (e. g. toxic epidermal necrolysis, Stevens-Johnson syndrome);

vasculitis; arthralgia; myalgia; serum sickness;

allergic pneumonitis;

interstitial nephritis; acute renal insufficiency or failure;

hepatitis; jaundice; acute hepatic necrosis or failure;

anemia, including hemolytic and aplastic; thrombocytopenia, including thrombotic thrombocytopenic purpura; leukopenia; agranulocytosis; pancytopenia; and/or other hematologic abnormalities.

The drug should be discontinued immediately at the first appearance of skin rash, jaundice, or any other sign of hypersensitivity and supportive measures instituted (see PRECAUTIONS, Information for Patients and ADVERSE REACTIONS ).

Clostridium difficile associated diarrhea (CDAD) has been reported with use of nearly all antibacterial agents, including Ofloxacin tablets, and may range in severity from mild diarrhea to fatal colitis. Treatment with antibacterial agents alters the normal flora of the colon leading to overgrowth of C. difficile .

C. difficile produces toxins A and B which contribute to the development of CDAD. Hypertoxin producing strains of C. difficile cause increased morbidity and mortality, as these infections can be refractory to antimicrobial therapy and may require colectomy. CDAD must be considered in all patients who present with diarrhea following antibiotic use. Careful medical history is necessary since CDAD has been reported to occur over two months after the administration of antibacterial agents.

If CDAD is suspected or confirmed, ongoing antibiotic use not directed against C. difficile may need to be discontinued. Appropriate fluid and electrolyte management, protein supplementation, antibiotic treatment of C. difficile, and surgical evaluation should be instituted as clinically indicated (see ADVERSE REACTIONS ).

Ofloxacin has not been shown to be effective in the treatment of syphilis.

Antimicrobial agents used in high doses for short periods of time to treat gonorrhea may mask or delay the symptoms of incubating syphilis. All patients with gonorrhea should have a serologic test for syphilis at the time of diagnosis. Patients treated with Ofloxacin for gonorrhea should have a follow-up serologic test for syphilis after three months and, if positive, treatment with an appropriate antimicrobial should be instituted.

Precautions

General

Prescribing Ofloxacin tablets in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria.

Adequate hydration of patients receiving Ofloxacin should be maintained to prevent the formation of a highly concentrated urine.

Administer Ofloxacin with caution in the presence of renal or hepatic insufficiency/impairment. In patients with known or suspected renal or hepatic insufficiency/impairment, careful clinical observation and appropriate laboratory studies should be performed prior to and during therapy since elimination of Ofloxacin may be reduced. In patients with impaired renal function (creatinine clearance ≤ 50 mg/mL), alteration of the dosage regimen is necessary (see CLINICAL PHARMACOLOGY and DOSAGE AND ADMINISTRATION ).

Moderate to severe photosensitivity/phototoxicity reactions, the latter of which may manifest as exaggerated sunburn reactions (e. g. burning, erythema, exudation, vesicles, blistering, edema) involving areas exposed to light (typically the face, “V” area of the neck, extensor surfaces of the forearms, dorsa of the hands), can be associated with the use of quinolones after sun or UV light exposure. Therefore, excessive exposure to these sources of light should be avoided. Drug therapy should be discontinued if photosensitivity/phototoxicity occurs (see ADVERSE REACTIONS. Postmarketing Adverse Events ).

As with other quinolones, Ofloxacin should be used with caution in any patient with a known or suspected CNS disorder that may predispose to seizures or lower the seizure threshold (e. g. severe cerebral arteriosclerosis, epilepsy) or in the presence of other risk factors that may predispose to seizures or lower the seizure threshold (e. g. certain drug therapy, renal dysfunction) (see WARNINGS and Drug Interactions ).

A possible interaction between oral hypoglycemic drugs (e. g. glyburide/glibenclamide) or with insulin and fluoroquinolone antimicrobial agents have been reported resulting in a potentiation of the hypoglycemic action of these drugs. The mechanism for this interaction is not known. If a hypoglycemic reaction occurs in a patient being treated with Ofloxacin, discontinue Ofloxacin immediately and consult a physician (see Drug Interactions and ADVERSE REACTIONS ).

As with any potent drug, periodic assessment of organ system functions, including renal, hepatic, and hematopoietic, is advisable during prolonged therapy (see WARNINGS and ADVERSE REACTIONS ).

Torsades de Pointes

Some quinolones, including Ofloxacin, have been associated with prolongation of the QT interval on the electrocardiogram and infrequent cases of arrhythmia. Rare cases of torsade de pointes have been spontaneously reported during postmarketing surveillance in patients receiving quinolones, including Ofloxacin. Ofloxacin should be avoided in patients with known prolongation of the QT interval, patients with uncorrected hypokalemia, and patients receiving Class IA (quinidine, procainamide), or Class III (amiodarone, sotalol) antiarrhythmic agents.

Information for Patients

Advise the patient to read the FDA-approved patient labeling (Medication Guide).

Serious Adverse Reactions

Advise patients to stop taking Ofloxacin if they experience an adverse reaction and to call their healthcare provider for advice on completing the full course of treatment with another antibacterial drug.

Inform patients of the following serious adverse reactions that have been associated with NOROXIN or other fluoroquinolone use:

Disabling and potentially irreversible serious adverse reactions that may occur together: Inform patients that disabling and potentially irreversible serious adverse reactions, includingtendinitis and tendon rupture, peripheral neuropathies, and central nervous system effects, havebeen associated with use of Ofloxacin and may occur together in the same patient. Inform patients to stop taking Ofloxacin immediately if they experience an adverse reaction and to calltheir healthcare provider.

Tendon Disorders: Instruct patients to contact their healthcare provider if they experience pain, swelling, or inflammation of a tendon, or weakness or inability to use one of their joints; rest and refrain from exercise; and discontinue Ofloxacin treatment. The risk of severe tendon disorders with fluoroquinolones is higher in older patients usually over 60 years of age, in patients taking corticosteroid drugs, and in patients with kidney, heart or lung transplants.

Peripheral Neuropathies: Inform patients that peripheral neuropathies have been associated with the use of Ofloxacin, that symptoms may occur soon after initiation of therapy and may be irreversible. If symptoms of peripheral neuropathy including pain, burning, tingling, numbness, and/or weakness develop, patients should immediately discontinue Ofloxacin and contact their physicians.

Central nervous system effects (for example, convulsions, dizziness, lightheadedness, increased intracranial pressure): Inform patients that convulsions have been reported in patients receiving fluoroquinolones, including Ofloxacin. Instruct patients to notify their physician before taking this drug if they have a history of convulsions. Inform patients that they should know how they react to Ofloxacin before they operate an automobile or machinery or engage in other activities requiring mental alertness and coordination. Instruct patients to notify their physician if persistent headache with or without blurred vision occurs.

Myasthenia gravis: Inform patients that fluoroquinolones like Ofloxacin may cause worsening of myasthenia gravis symptoms, including muscle weakness and breathing problems. Patients should call their healthcare provider right away if you have any worsening muscle weakness or breathing problems.

Hypersensitivity Reactions: Inform patients that Ofloxacin can cause hypersensitivity reactions, even following a single dose, and to discontinue the drug at the first sign of a skin rash, hives or other skin reactions, a rapid heartbeat, difficulty in swallowing or breathing, any swelling suggesting angioedema (for example, swelling of the lips, tongue, face, tightness of the throat, hoarseness), or other symptoms of an allergic reaction.

Hepatotoxicity: Inform patients that severe hepatotoxicity (including acute hepatitis and fatal events) has been reported in patients taking Ofloxacin. Instruct patients to inform their physician if they experience any signs or symptoms of liver injury including: loss of appetite, nausea, vomiting, fever, weakness, tiredness, right upper quadrant tenderness, itching, yellowing of the skin and eyes, light colored bowel movements or dark colored urine.

Diarrhea: Diarrhea is a common problem caused by antibiotics which usually ends when the antibiotic is discontinued. Sometimes after starting treatment with antibiotics, patients can develop watery and bloody stools (with or without stomach cramps and fever) even as late as two or more months after having taken the last dose of the antibiotic. If this occurs, instruct patients to contact their physician as soon as possible.

Photosensitivity/Phototoxicity: Inform patients that photosensitivity/phototoxicity has been reported in patients receiving fluoroquinolones. Patients should minimize or avoid exposure to natural or artificial sunlight (tanning beds or UVA/B treatment) while taking quinolones. If patients need to be outdoors while using quinolones, they should wear loosefitting clothes that protect skin from sun exposure and discuss other sun protection measures with their physician. If a sunburn-like reaction or skin eruption occurs, patients should contact their physician.

Other Information

Patients should be advised:

to drink fluids liberally.

that mineral supplements, vitamins with iron or minerals, calcium-, aluminum - or magnesium based antacids, sucralfate or didanosine, chewable/buffered tablets or the pediatric powder for oral solution should not be taken within the two-hour period before or within the two-hour period after taking Ofloxacin (see Drug Interactions );

that Ofloxacin can be taken without regard to meals;

Patients should be counseled that antibacterial drugs including Ofloxacin tablets should only be used to treat bacterial infections. They do not treat viral infections (e. g. the common cold). When Ofloxacin tablets are prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed. Skipping doses or not completing the full course of therapy may (1) decrease the effectiveness of the immediate treatment and (2) increase the likelihood that bacteria will develop resistance and will not be treatable by Ofloxacin tablets or other antibacterial drugs in the future.;

that if they are diabetic and are being treated with insulin or an oral hypoglycemic drug, to discontinue Ofloxacin immediately if a hypoglycemic reaction occurs and consult a physician (see PRECAUTIONS, General and Drug Interactions );

that convulsions have been reported in patients taking quinolones, including Ofloxacin, and to notify their physician before taking this drug if there is a history of this condition;

to inform their physician of any personal or family history of QT c prolongation or proarrhythmic conditions such as hypokalemia, bradycardia, or recent myocardial ischemia; if they are taking any class IA (quinidine, procainamide), or class III (amiodarone, sotalol) antiarrhythmic agents. Patients should notify their physicians if they have any symptoms of prolongation of the QT c interval including prolonged heart palpitations or a loss of consciousness.

Drug Interactions

Antacids, Sucralfate, Metal Cations, Multivitamins:

Quinolones form chelates with alkaline earth and transition metal cations. Administration of quinolones with antacids containing calcium, magnesium, or aluminum, with sucralfate, with divalent or trivalent cations such as iron, or with multivitamins containing zinc or with didanosine, chewable/buffered tablets or the pediatric powder for oral solution may substantially interfere with the absorption of quinolones resulting in systemic levels considerably lower than desired. These agents should not be taken within the two-hour period before or within the two-hour period after Ofloxacin administration (see DOSAGE AND ADMINISTRATION ).

Interactions between Ofloxacin and caffeine have not been detected.

Cimetidine has demonstrated interference with the elimination of some quinolones. This interference has resulted in significant increases in half-life and AUC of some quinolones. The potential for interaction between Ofloxacin and cimetidine has not been studied.

Elevated serum levels of cyclosporine have been reported with concomitant use of cyclosporine with some other quinolones. The potential for interaction between Ofloxacin and cyclosporine has not been studied.

Drugs Metabolized by Cytochrome P450 Enzymes:

Most quinolone antimicrobial drugs inhibit cytochrome P450 enzyme activity. This may result in a prolonged half-life for some drugs that are also metabolized by this system (e. g. cyclosporine, theophylline/methylxanthines, warfarin) when coadministered with quinolones. The extent of this inhibition varies among different quinolones (see other Drug Interactions ).

Non-Steroidal Anti-Inflammatory Drugs:

The concomitant administration of a non-steroidal anti-inflammatory drug with a quinolone, including Ofloxacin, may increase the risk of CNS stimulation and convulsive seizures (see WARNINGS and PRECAUTIONS, General ).

The concomitant use of probenecid with certain other quinolones has been reported to affect renal tubular secretion. The effect of probenecid on the elimination of Ofloxacin has not been studied.

Steady-state theophylline levels may increase when Ofloxacin and theophylline are administered concurrently. As with other quinolones, concomitant administration of Ofloxacin may prolong the half-life of theophylline, elevate serum theophylline levels, and increase the risk of theophylline-related adverse reactions. Theophylline levels should be closely monitored and theophylline dosage adjustments made, if appropriate, when Ofloxacin is co administered. Adverse reactions (including seizures) may occur with or without an elevation in the serum theophylline level (see WARNINGS and PRECAUTIONS, General ).

Some quinolones have been reported to enhance the effects of the oral anticoagulant warfarin or its derivatives. Therefore, if a quinolone antimicrobial is administered concomitantly with warfarin or its derivatives, the prothrombin time or other suitable coagulation test should be closely monitored.

Antidiabetic Agents (e. g. Insulin, Glyburide/Glibenclamide):

Since disturbances of blood glucose, including hyperglycemia and hypoglycemia, have been reported in patients treated concurrently with quinolones and an antidiabetic agent, careful monitoring of blood glucose is recommended when these agents are used concomitantly (see PRECAUTIONS, General and Information for Patients ).

Interaction With Laboratory or Diagnostic Testing

Some quinolones, including Ofloxacin, may produce false-positive urine screening results for opiates using commercially available immunoassay kits. Confirmation of positive opiate screens by more specific methods may be necessary.

Carcinogenesis, Mutagenesis, Impairment of Fertility

Long-term studies to determine the carcinogenic potential of Ofloxacin have not been conducted.

Ofloxacin was not mutagenic in the Ames bacterial test, in vitro and in vivo cytogenetic assay, sister chromatid exchange (Chinese Hamster and Human Cell Lines), unscheduled DNA Repair (UDS) using human fibroblasts, dominant lethal assays, or mouse micronucleus assay. Ofloxacin was positive in the UDS test using rat hepatocytes and Mouse Lymphoma Assay.

Pregnancy

Pregnancy category C

Ofloxacin has not been shown to have any teratogenic effects at oral doses as high as 810 mg/kg/day (11 times the recommended maximum human dose based on mg/m 2 or 50 times based on mg/kg) and 160 mg/kg/day (4 times the recommended maximum human dose based on mg/m 2 or 10 times based on mg/kg) when administered to pregnant rats and rabbits, respectively. Additional studies in rats with oral doses up to 360 mg/kg/day (5 times the recommended maximum human dose based on mg/m 2 or 23 times based on mg/kg) demonstrated no adverse effect on late fetal development, labor, delivery, lactation, neonatal viability, or growth of the newborn. Doses equivalent to 50 and 10 times the recommended maximum human dose of Ofloxacin (based on mg/kg) were fetotoxic (i. e. decreased fetal body weight and increased fetal mortality) in rats and rabbits, respectively. Minor skeletal variations were reported in rats receiving doses of 810 mg/kg/day, which is more than 10 times higher than the recommended maximum human dose based on mg/m 2 .

There are, however, no adequate and well-controlled studies in pregnant women. Ofloxacin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus (see WARNINGS ).

Nursing Mothers

In lactating females, a single oral 200 mg dose of Ofloxacin resulted in concentrations of Ofloxacin in milk that were similar to those found in plasma. Because of the potential for serious adverse reactions from Ofloxacin in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother (see WARNINGS and ADVERSE REACTIONS ).

Pediatric Use

Safety and effectiveness in pediatric patients and adolescents below the age of 18 years have not been established. Ofloxacin causes arthropathy (arthrosis) and osteochondrosis in juvenile animals of several species (see WARNINGS ).

Geriatric Use

Geriatric patients are at increased risk for developing severe tendon disorders including tendon rupture when being treated with a fluoroquinolone such as Ofloxacin. This risk is further increased in patients receiving concomitant corticosteroid therapy. Tendinitis or tendon rupture can involve the Achilles, hand, shoulder, or other tendon sites and can occur during or after completion of therapy; cases occurring up to several months after fluoroquinolone treatment have been reported. Caution should be used when prescribing Ofloxacin to elderly patients especially those on corticosteroids. Patients should be informed of this potential side effect and advised to discontinue Ofloxacin and contact their healthcare provider if any symptoms of tendinitis or tendon rupture occur (see Boxed Warning ; WARNINGS ; and ADVERSE REACTIONS. Postmarketing Adverse Event Reports ).

In phase 2/3 clinical trials with Ofloxacin, 688 patients (14.2%) were ≥ 65 years of age. Of these, 436 patients (9.0%) were between the ages of 65 and 74 and 252 patients (5.2%) were 75 years or older. There was no apparent difference in the frequency or severity of adverse reactions in elderly adults compared with younger adults. The pharmacokinetic properties of Ofloxacin in elderly subjects are similar to those in younger subjects. Drug absorption appears to be unaffected by age. Dosage adjustment is necessary for elderly patients with impaired renal function (creatinine clearance rate ≤ 50 mL/min) due to reduced clearance of Ofloxacin. In comparative studies, the frequency and severity of most drug-related nervous system events in patients ≥ 65 years of age were comparable for Ofloxacin and control drugs. The only differences identified were an increase in reports of insomnia (3.9% vs 1.5%) and headache (4.7% vs 1.8%) with Ofloxacin. It is important to note that these geriatric safety data are extracted from 44 comparative studies where the adverse reaction information from 20 different controls (other antibiotics or placebo) were pooled for comparison with Ofloxacin. The clinical significance of such a comparison is not clear (see CLINICAL PHARMACOLOGY and DOSAGE AND ADMINISTRATION ).

Elderly patients may be more sensitive to drug-associated effects on the QT interval. Therefore, precaution should be taken when using Ofloxacin with concomitant drugs that can result in prolongation of the QT interval (e. g. Class IA or Class III antiarrhythmics) or in patients with risk factors for Torsade de pointes (e. g. known QT prolongation, uncorrected hypokalemia) (see PRECAUTIONS, General. Torsades de Pointes ).

Adverse Reactions

The following is a compilation of the data for Ofloxacin based on clinical experience with both the oral and intravenous formulations. The incidence of drug-related adverse reactions in patients during Phase 2 and 3 clinical trials was 11%. Among patients receiving multiple-dose therapy, 4% discontinued Ofloxacin due to adverse experiences.

In clinical trials, the following events were considered likely to be drug-related in patients receiving multiple doses of Ofloxacin:

nausea 3%, insomnia 3%, headache 1%, dizziness 1%, diarrhea 1%, vomiting 1%, rash 1%, pruritus 1%, external genital pruritus in women 1%, vaginitis 1%, dysgeusia 1%.

In clinical trials, the most frequently reported adverse events, regardless of relationship to drug, were:

nausea 10%, headache 9%, insomnia 7%, external genital pruritus in women 6%, dizziness 5%, vaginitis 5%, diarrhea 4%, vomiting 4%.

In clinical trials, the following events, regardless of relationship to drug, occurred in 1 to 3% of patients:

abdominal pain and cramps, chest pain, decreased appetite, dry mouth, dysgeusia, fatigue, flatulence, gastrointestinal distress, nervousness, pharyngitis, pruritus, fever, rash, sleep disorders, somnolence, trunk pain, vaginal discharge, visual disturbances, and constipation.

Additional events, occurring in clinical trials at a rate of less than 1%, regardless of relationship to drug, were:

Body as a Whole:

In clinical trials using multiple-dose therapy, ophthalmologic abnormalities, including cataracts and multiple punctate lenticular opacities, have been noted in patients undergoing treatment with other quinolones. The relationship of the drugs to these events is not presently established.

CRYSTALLURIA and CYLINDRURIA HAVE BEEN REPORTED with other quinolones.

Overdosage

Information on overdosage with Ofloxacin is limited. One incident of accidental overdosage has been reported. In this case, an adult female received 3 grams of Ofloxacin intravenously over 45 minutes. A blood sample obtained 15 minutes after the completion of the infusion revealed an Ofloxacin level of 39.3 mcg/mL. In 7 h, the level had fallen to 16.2 mcg/mL, and by 24 h to 2.7 mcg/mL. During the infusion, the patient developed drowsiness, nausea, dizziness, hot and cold flushes, subjective facial swelling and numbness, slurring of speech, and mild to moderate disorientation. All complaints except the dizziness subsided within 1 h after discontinuation of the infusion. The dizziness, most bothersome while standing, resolved in approximately 9 h. Laboratory testing reportedly revealed no clinically significant changes in routine parameters in this patient.

In the event of an acute overdose, the stomach should be emptied. The patient should be observed and appropriate hydration maintained. Ofloxacin is not efficiently removed by hemodialysis or peritoneal dialysis.

Ofloxacin Dosage and Administration

The usual dose of Ofloxacin Tablets, USP is 200 mg to 400 mg orally every 12 h as described in the following dosing chart. These recommendations apply to patients with normal renal function (i. e. creatinine clearance > 50 mL/min). For patients with altered renal function (i. e. creatinine clearance ≤ 50 mL/min), see the Patients with Impaired Renal Function subsection.

When only the serum creatinine is known, the following formula may be used to estimate creatinine clearance.

Women: 0.85 × the value calculated for men.

The serum creatinine should represent a steady-state of renal function.

Patients with Cirrhosis

The excretion of Ofloxacin may be reduced in patients with severe liver function disorders (e. g. cirrhosis with or without ascites). A maximum dose of 400 mg of Ofloxacin per day should therefore not be exceeded.

How is Ofloxacin Supplied

Ofloxacin Tablets, USP 400 mg are white, modified capsule shaped, biconvex film coated tablets. Each tablet is distinguished by an imprint of “LL713” on one side and blank on the other side. They are available in bottles of 100 tablets (NDC 68047-713-01).

Ofloxacin Tablets, USP should be stored in well-closed containers. Store at 20°-25°C (68°-77°F) [See USP Controlled Room Temperature].

Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required).

KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDREN.

Animal Pharmacology

Ofloxacin, as well as other drugs of the quinolone class, has been shown to cause arthropathies (arthrosis) in immature dogs and rats. In addition, these drugs are associated with an increased incidence of osteochondrosis in rats as compared to the incidence observed in vehicle-treated rats (see WARNINGS ). There is no evidence of arthropathies in fully mature dogs at intravenous doses up to 3 times the recommended maximum human dose (on a mg/m 2 basis or 5 times based on mg/kg basis), for a one-week exposure period.

Long-term, high-dose systemic use of other quinolones in experimental animals has caused lenticular opacities; however, this finding was not observed in any animal studies with Ofloxacin.

Reduced serum globulin and protein levels were observed in animals treated with other quinolones. In one Ofloxacin study, minor decreases in serum globulin and protein levels were noted in female cynomolgus monkeys dosed orally with 40 mg/kg Ofloxacin daily for one year. These changes, however, were considered to be within normal limits for monkeys.

Crystalluria and ocular toxicity were not observed in any animals treated with Ofloxacin.

REFERENCES

Clinical and Laboratory Standards Institute (CLSI). Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically; Approved Standard - Ninth Edition. CLSI document M07-A9, Clinical and Laboratory Standards Institute, 950 West Valley Road, Suite 2500, Wayne, Pennsylvania 19087, USA, 2012.

Clinical and Laboratory Standards Institute (CLSI). Performance Standards for Antimicrobial Disk Diffusion Susceptibility Tests; Approved Standard – Eleventh Edition. CLSI document M02-A11, Clinical and Laboratory Standards Institute, 950 West Valley Road, Suite 2500, Wayne, Pennsylvania 19087, USA, 2012.

Clinical and Laboratory Standards Institute (CLSI). Performance Standards for Antimicrobial Susceptibility Testing; Twenty-third Informational Supplement, CLSI document M100-S24, Clinical and Laboratory Standards Institute, 950 West Valley Road, Suite 2500, Wayne, Pennsylvania 19087, USA, 2014.

Larken Laboratories, Inc.

Canton, Mississippi 39046

Toll Free: 1-888-527-5522

MEDICATION GUIDE

Ofloxacin TABLETS (oh floks' a sin)

Read the Medication Guide that comes with Ofloxacin before you start taking it and each time you get a refill. There may be new information. This Medication Guide does not take the place of talking to your healthcare provider about your medical condition or your treatment.

What is the most important information I should know about Ofloxacin tablets?

Ofloxacin belongs to a class of antibiotics called fluoroquinolones. Ofloxacin tablets can cause serious side effects. Some of these serious side effects can happen at the same time and could result in death. If you get any of the following serious side effects, get medical help right away. Talk with your healthcare provider about whether you should continue to take Ofloxacin tablets.

1. Tendon rupture or swelling of the tendon (tendinitis).

Tendon problems can happen in people of all ages who take Ofloxacin tablets. Tendons are tough cords of tissue that connect muscles to bones.

Pain, swelling, tears, and inflammation of tendons including the back of the ankle (Achilles), shoulder, hand, or other tendon sites.

The risk of getting tendon problems while you take Ofloxacin tablets is higher if you:

are over 60 years of age

are taking steroids (corticosteroids)

have had a kidney, heart or lung transplant.

Tendon problems can happen in people who do not have the above risk factors when they take Ofloxacin tablets. Other reasons that can increase your risk of tendon problems can include:

physical activity or exercise

kidney failure

tendon problems in the past, such as in people with rheumatoid arthritis (RA).

Stop taking Ofloxacin immediately and get medical help right away at the first sign of tendon pain, swelling or inflammation. Stop taking Ofloxacin tablets until tendinitis or tendon rupture has been ruled out by your healthcare provider. Avoid exercise and using the affected area. The most common area of pain and swelling is the Achilles tendon at the back of your ankle. This can also happen with other tendons.

Talk to your healthcare provider about the risk of tendon rupture with continued use of Ofloxacin tablets. You may need a different antibiotic that is not a fluoroquinolone to treat your infection.

Tendon rupture can happen while you are taking or after you have finished taking Ofloxacin tablets. Tendon ruptures have happened up to several months after patients have finished taking their fluoroquinolone.

Get medical help right away if you get any of the following signs or symptoms of a tendon rupture:

hear or feel a snap or pop in a tendon area

bruising right after an injury in a tendon area

unable to move the affected area or bear weight

2. Changes in sensation and possible nerve damage (Peripheral Neuropathy). Damage to the nerves in arms, hands, legs, or feet can happen in people who take fluoroquinolones, including Ofloxacin. Stop taking Ofloxacin immediately and talk to your healthcare provider right away if you get any of the following symptoms of peripheral neuropathy in your arms, hands, legs, or feet:

The nerve damage may be permanent.

3. Central Nervous System (CNS) effects. Seizures have been reported in people who take fluoroquinolone antibacterial medicines, including Ofloxacin. Tell your healthcare provider if you have a history of seizures before you start taking Ofloxacin. CNS side effects may happen as soon as after taking the first dose of Ofloxacin. Stop taking Ofloxacin immediately and talk to your healthcare provider right away if you get any of these side effects, or other changes in mood or behavior:

seizures

hear voices, see things, or sense things that are not there (hallucinations)

feel restless

tremors

feel anxious or nervous

confusion

depression

trouble sleeping

nightmares

feel lightheaded or dizzy

feel more suspicious (paranoia)

suicidal thoughts or acts

headaches that will not go away, with or without blurred vision

4. Worsening of myasthenia gravis (a disease that causes muscle weakness).

Fluoroquinolones like Ofloxacin tablets may cause worsening of myasthenia gravis symptoms, including muscle weakness and breathing problems. Call your healthcare provider right away if you have any worsening muscle weakness or breathing problems.

See the section "What are the possible side effects of Ofloxacin tablets?" for more information about side effects.

What is Ofloxacin?

Ofloxacin tablets are a fluoroquinolone antibiotic medicine used in adults to treat certain infections caused by certain germs called bacteria. It is not known if Ofloxacin tablets are safe and work in people under 18 years of age. Children less than 18 years of age have a higher chance of getting bone, joint, or tendon (musculoskeletal) problems such as pain or swelling while taking Ofloxacin tablets.

Sometimes infections are caused by viruses rather than by bacteria. Examples include viral infections in the sinuses and lungs, such as the common cold or flu. Antibiotics, including Ofloxacin tablets, do not kill viruses.

Call your healthcare provider if you think your condition is not getting better while you are taking Ofloxacin tablets.

Who should not take Ofloxacin tablets?

Do not take Ofloxacin tablets if you have ever had a severe allergic reaction to an antibiotic known as a fluoroquinolone, or if you are allergic to any of the ingredients in Ofloxacin. Ask your healthcare provider if you are not sure. See the list of the ingredients in Ofloxacin tablets at the end of this Medication Guide.

What should I tell my healthcare provider before taking Ofloxacin tablets?

See "What is the most important information I should know about Ofloxacin tablets?"

Tell your healthcare provider about all your medical conditions, including if you:

have tendon problems - Ofloxacin should not be used in patients who have a history of tendon problems

have a disease that causes muscle weakness (myasthenia gravis)

have central nervous system problems (such as epilepsy)

have nerve problems - Ofloxacin should not be used in patients who have a history of nerve problems called peripheral neuropathy

have or anyone in your family has an irregular heartbeat, especially a condition called "QT prolongation."

have low blood potassium (hypokalemia)

have a history of seizures

have kidney problems. You may need a lower dose of Ofloxacin tablets if your kidneys do not work well.

have liver problems

have rheumatoid arthritis (RA) or other history of joint problems

are pregnant or planning to become pregnant. It is not known if Ofloxacin tablets will harm your unborn child.

are breastfeeding or planning to breastfeed. Ofloxacin passes into breast milk. You and your healthcare provider should decide whether you will take Ofloxacin tablets or breastfeed.

Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, herbal and dietary supplements. Ofloxacin tablets and other medicines can affect each other causing side effects. Especially tell your healthcare provider if you take:

an NSAID (Non-Steroidal Anti-Inflammatory Drug). Many common medicines for pain relief are NSAIDs. Taking an NSAID while you take Ofloxacin tablets or other fluoroquinolones may increase your risk of central nervous system effects and seizures. See " What are the possible side effects of Ofloxacin tablets? "

theophylline

a blood thinner (warfarin, Coumadin ®. Jantoven ® )

an oral anti-diabetes medicine or insulin

a medicine to control your heart rate or rhythm (antiarrhythmics). See "What are the possible side effects of Ofloxacin tablets?" .

an anti-psychotic medicine

a tricyclic antidepressant

a water pill (diuretic)

a steroid medicine. Corticosteroids taken by mouth or by injection may increase the chance of tendon injury. See "What is the most important information I should know about Ofloxacin tablets?" .

Certain medicines may keep Ofloxacin tablets from working correctly. Take Ofloxacin tablets either 2 hours before or 2 hours after taking these products:

an antacid, multivitamin, or other product that has magnesium, aluminum, iron, or zinc.

sucralfate (Carafate ® )

didanosine (Videx ®,Videx ® EC)

Ask your healthcare provider if you are not sure if any of your medicines are listed above. Know the medicines you take. Keep a list of your medicines and show it to your healthcare provider and pharmacist when you get a new medicine.

How should I take Ofloxacin tablets?

Take Ofloxacin tablets exactly as prescribed by your healthcare provider.

Take Ofloxacin tablets at about the same time each day.

Drink plenty of fluids while taking Ofloxacin tablets.

Ofloxacin tablets can be taken with or without food.

Do not skip any doses, or stop taking Ofloxacin tablets even if you begin to feel better, until you finish your prescribed treatment, unless:

you have tendon effects (see "What is the most important information I should know about Ofloxacin tablets?"

Buy Online Ofloxacin - Fda Prescribing Information, Side Effects And Uses, Oxacin

Etodolac Side Effects In Detail, Todolac

Etodolac Side Effects

For the Consumer

Applies to etodolac: oral capsule, oral tablet, oral tablet extended release

In addition to its needed effects, some unwanted effects may be caused by etodolac. In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking etodolac:

More common:

Abdominal or stomach bloating, burning, cramping, or pain

belching

bloody or black, tarry stools

blurred vision

body aches or pain

cloudy urine

congestion

constipation

cough or hoarseness

decrease in urine output or decrease in urine-concentrating ability

diarrhea

dizziness

dryness or soreness of throat

feeling of indigestion

fever or chills

headache

increased bleeding time

itching skin

loss of appetite

lower back or side pain

nausea and vomiting

nervousness

pain in the chest below the breastbone

painful or difficult urination

pale skin

pounding in the ears

rash

runny nose

severe stomach pain

slow or fast heartbeat

swelling

tender, swollen glands in neck

trouble in swallowing

troubled breathing with exertion

unusual bleeding or bruising

unusual tiredness or weakness

voice changes

vomiting of blood or material that looks like coffee grounds

weight loss

Symptoms of overdose:

Agitation

change in consciousness

confusion

depression

difficult or troubled breathing

hives

hostility

irregular, fast or slow, or shallow breathing

irritability

loss of consciousness

muscle twitching

pain or discomfort in chest, upper stomach, or throat

pale or blue lips, fingernails, or skin

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

rapid weight gain

seizures

shortness of breath

sleepiness

stupor

swelling of face, ankles, or hands

tightness in chest

unusual drowsiness, dullness, or feeling of sluggishness

wheezing

Minor Side Effects

Some of the side effects that can occur with etodolac may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:

Bloated, full feeling

continuing ringing or buzzing or other unexplained noise in ears

excess air or gas in stomach or intestines

hearing loss

lack or loss of strength

passing gas

sneezing

stuffy nose

For Healthcare Professionals

Applies to etodolac: oral capsule, oral tablet, oral tablet extended release

Gastrointestinal

Serious GI toxicity, such as inflammation, bleeding, ulceration, and perforation of the stomach, small intestine or large intestine, can occur at any time, with or without warning symptoms, in patients treated chronically with NSAIDs.

In one safety review, the overall incidence of serious GI side effects associated with etodolac use ranged from 0.3% to 0.6%. The manufacturer cites a higher incidence, 2% to 4%, of serious GI events in patients treated with NSAIDs for up to one year.

Patients with a history of serious GI events or alcohol abuse are at increased risk for severe GI side effects. [Ref ]

Gastrointestinal (GI) side effects have included dyspepsia (1% to 13%) and abdominal pain (3% to 11%). Heartburn, gastric ulcers (gastric/duodenal), GI bleeding/perforation, vomiting, nausea, diarrhea, and flatulence have been reported in 1% to 10% of patients. Melena, constipation, gastritis, abdominal distension, epigastric pain, and abnormal stools have been reported in greater than 1% and less than 3% of patients. Other side effects reported in less than 1% of patients have included GI discomfort, burning sensation, eructation, blood in stools, gastralgia, upper abdominal discomfort, thirst, dry mouth, intestinal ulceration, anorexia, duodenitis, and esophagitis with or without stricture or cardiospasm. More serious side effects reported in less than 1% of patients have included peptic ulcers with or without perforation, pancreatitis, and colitis. Gastritis, ulcerative stomatitis, and colonic strictures have been reported. In addition, glossitis, and hematemesis have also been reported with the use of NSAIDs. [Ref ]

Renal

Renal side effects including renal impairment, elevations in serum creatinine and blood urea nitrogen, renal insufficiency, renal failure, renal papillary necrosis, interstitial nephritis, and renal calculi have been reported in less than 1% of patients. Abnormal renal function and proteinuria have been reported. Oliguria/polyuria has also been reported with the use of NSAIDs. [Ref ]

Elevations in serum creatinine and blood urea nitrogen are typically minor and transient. However, in one safety review, abnormal renal function tests resulted in study withdrawal in 0.3% of patients treated with etodolac.

Etodolac may impair the ability of the kidney to cope with low renal blood flow states due to inhibition of prostaglandin-dependent afferent arteriolar vasodilation. Renal function may be further compromised in patients with heart failure, hypovolemia, cirrhosis, nephrotic syndrome, or hypoalbuminemia. Additional risk factors for etodolac-induced renal insufficiency are advanced age and concomitant use of diuretics.

A case-control study suggested that patients who consumed 5000 or more pills containing NSAIDs during their lifetime may be at increased risk of end-stage renal disease. [Ref ]

Hepatic

Hepatic side effects have included elevations in serum transaminases in up to 15% of patients. Hepatic failure, jaundice, cholestatic jaundice, elevated liver enzymes, hepatitis, and cholestatic hepatitis have been reported in less than 1% of patients. [Ref ]

Elevations in serum transaminases three times normal values are reported in less than 1% of patients treated with etodolac. In one safety review, etodolac was discontinued in 0.9% of patients due to elevations in liver function tests. [Ref ]

Hematologic

Hematologic side effects including anemia, thrombocytopenia, increased bleeding time, leukopenia, neutropenia, agranulocytosis, hemolytic anemia, pancytopenia, aplastic anemia, and ecchymosis have been reported in less than 1% of patients. Lymphadenopathy has also been reported with the use of NSAIDs. [Ref ]

Dermatologic

Dermatologic side effects including pruritus and rash have been reported in greater than 1% and less than 3% of patients. Exfoliative dermatitis, leukocytoclastic vasculitis, sweating, alopecia, photosensitivity, skin peeling, hyperpigmentation, vesiculobullous rash, and maculopapular rash have been reported in less than 1% of patients. [Ref ]

Hypersensitivity

Hypersensitivity side effects including urticaria, angioedema, cutaneous vasculitis with purpura, Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme, allergic reactions, anaphylactic/anaphylactoid reactions (including shock) have been reported in less in than 1% of patients. At least one case of hypersensitivity vasculitis mimicking temporal arteritis has also been reported. [Ref ]

Metabolic

Metabolic side effects have been reported rarely. Hyperglycemia has been reported in previously in controlled diabetic patients (less than 1%), although causality is unknown. Change in weight has also been reported in less than 1% of patients. [Ref ]

Nervous system

Nervous system side effects have included asthenia (2% to 9%), malaise (3% to 9%), headache (5%), and dizziness (3% to 9%). Fatigue and nervousness have been reported in greater than 1% and less than 3% of patients. Insomnia, somnolence, confusion, paresthesias, and irritability have been reported in less than 1% of patients. In addition, convulsions, coma, meningitis, tremors, vertigo, anxiety, dream abnormalities, and hallucinations have also been reported with the use of NSAIDs. [Ref ]

Psychiatric

Psychiatric side effects have included depression (greater than 1% and less than 3%), insomnia, and somnolence. In addition, anxiety, dream abnormalities, and hallucinations have also been reported with the use of NSAIDs. [Ref ]

Cardiovascular

Cardiovascular side effects have included worsening of heart failure and elevated blood pressure. Hypertension, edema, congestive heart failure, flushing, palpitations, syncope, vasculitis (including necrotizing and allergic), arrhythmias, myocardial infarction, and cerebrovascular accident have been reported in less than 1% of patients. Tachycardia has also been reported with the use of NSAIDs. [Ref ]

Genitourinary

Genitourinary side effects including dysuria and urinary frequency have been reported in greater than 1% and less than 3% of patients. Cystitis, hematuria, leukorrhea, and bleeding irregularities have been reported in less than 1% of patients. Intrauterine bleeding has also been reported. [Ref ]

Ocular

Ocular side effects including blurred vision have been reported in greater than 1% and less than 3% of patients. Photophobia, transient visual disturbances, and conjunctivitis have been reported in less than 1% of patients. [Ref ]

General

General side effects associated with the use of NSAIDs have included sepsis and death. [Ref ]

Respiratory

Respiratory side effects have included pulmonary infiltration. Bronchitis, dyspnea, asthma, pharyngitis, eosinophilia, rhinitis, bronchospasm, and sinusitis have been reported in less than 1% of patients. Respiratory depression and pneumonia have also been reported with the use of NSAIDs. [Ref ]

Musculoskeletal

Musculoskeletal side effects have included arthralgia (greater than 1% and less than 3%) and muscle pain (less than 1%).

Other

Other side effects including chills, fever, and tinnitus have been reported in greater than 1% and less than 3% of patients. Loss of taste, infection, and taste perversion have been reported in less than 1% of patients. Dysgeusia (altered taste) has also been reported. [Ref ]

References

1. Schattenkirchner M "An updated safety profile of etodolac in several thousand patients." Eur J Rheumatol Inflamm 10 (1990): 56-65

2. van Eeden A, Schotborgh RH, Tytgat GN "An endoscopic evaluation of the effects of etodolac and diclofenac on the gastric and duodenal mucosa." Clin Ther 12 (1990): 496-502

3. Taha AS, McLaughlin S, Holland PJ, Kelly RW, Sturrock RD, Russell RI "Effect on gastric and duodenal mucosal prostaglandins of repeated intake of therapeutic doses of naproxen and etodolac in rheumatoid arthritis." Ann Rheum Dis 49 (1990): 354-8

4. Singh G, Ramey DR, Morfeld D, Fries JF "Comparative toxicity of non-steroidal anti-inflammatory agents." Pharmacol Ther 62 (1994): 175-91

5. Eis MJ, Watkins BM, Philip A, Welling RE "Nonsteroidal-induced benign strictures of the colon: a case report and review of the literature." Am J Gastroenterol 93 (1998): 120-1

6. Salom IL, Jacob G, Jallad N, Perdomo CA, Mullane JF, Weidler D "Gastrointestinal microbleeding associated with the use of etodolac, ibuprofen, indomethacin, and naproxen in normal males." J Clin Pharmacol 24 (1984): 240-6

7. Bianchi Porro G, Caruso I, Petrillo M, Montrone F, Ardizzone S "A double-blind gastroscopic evaluation of the effects of etodolac and naproxen on the gastrointestinal mucosa of rheumatic patients." J Intern Med 229 (1991): 5-8

8. Lanza F, Rack MF, Lynn M, Wolf J, Sanda M "An endoscopic comparison of the effects of etodolac, indomethacin, ibuprofen, naproxen, and placebo on the gastrointestinal mucosa." J Rheumatol 14 (1987): 338-41

9. Weideman RA, Kelly KC, Kazi S, et al. "Risks of clinically significant upper gastrointestinal events with etodolac and naproxen: A historical cohort analysis." Gastroenterology 127 (2004): 1322-8

10. "Product Information. Lodine (etodolac)." Wyeth-Ayerst Laboratories, Philadelphia, PA.

11. Wilcox GM, Porensky RS "Acute colitis associated with etodolac." J Clin Gastroenterol 25 (1997): 367-8

12. Shand DG, Epstein C, Kinberg-Calhoun J, et al "The effect of etodolac administration on renal function in patients with arthritis." J Clin Pharmacol 26 (1986): 269-74

13. Brater DC, Brown-Cartwright D, Anderson SA, Uaamnuichai M "Effect of high-dose etodolac on renal function." Clin Pharmacol Ther 42 (1987): 283-9

14. Perneger TV, Whelton PK, Klag MJ "Risk of kidney failure associated with the use of acetaminophen, aspirin, and nonsteroidal antiinflammatory drugs." N Engl J Med 331 (1994): 1675-9

15. Brater DC, Anderson SA, Brown-Cartwright D, Toto RD, Chen A, Jacob GB "Effect of etodolac in patients with moderate renal impairment compared with normal subjects." Clin Pharmacol Ther 38 (1985): 674-9

16. Mabee CL, Mabee SW, Baker PB, Kirkpatrick RB, Levine EJ "Fulminant hepatic failure associated with etodolac use." Am J Gastroenterol 90 (1995): 659-61

17. Cramer RL, Aboko-Cole VC, Gualtieri RJ "Agranulocytosis associated with etodolac." Ann Pharmacother 28 (1994): 458-60

18. Romano A, Pietrantonio F, Difonso M, Garcovich A, Chiarelli C, Venuti A, Barone C "Positivity of patch tests in cutaneous reaction to diclofenac - two case reports." Allergy 49 (1994): 57-9

19. Lie JT, Dixit RK "Nonsteroidal antiinflammatory drug induced hypersensitivity vasculitis clinically mimicking temporal arteritis." J Rheumatol 23 (1996): 183-5

20. Gurwitz JH, Avron J, Bohn RL, Glynn RJ, Monane M, Mogun H "Initiation of antihypertensive treatment during nonsteroidal anti-inflammatory drug therapy." JAMA 272 (1994): 781-6

21. Johnson AG, Nguyen TV, Day RO "Do nonsteroidal anti-inflammatory drugs affect blood pressure? A meta-analysis." Ann Intern Med 121 (1994): 289-300

Not all side effects for etodolac may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here .



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Procetofen, Procetofen

Procetofen

Procetofen - General Information

An antilipemic agent which reduces both cholesterol and triglycerides in the blood. [PubChem]

Pharmacology of Procetofen

Procetofen is a lipid regulating agent indicated as adjunctive therapy to diet to reduce elevated LDL-C, Total-C, Triglycerides and Apo B, and to increase HDL-C in adult patients with primary hypercholesterolemia or mixed dyslipidemia (Fredrickson Types IIa and IIb). Procetofen is also indicated as adjunctive therapy to diet for treatment of adult patients with hypertriglyceridemia (Fredrickson Types IV and V hyperlipidemia). Fenofibric acid, the active metabolite of Procetofen, produces reductions in total cholesterol, LDL cholesterol, apolipoprotein B, total triglycerides and triglyceride rich lipoprotein (VLDL) in treated patients. In addition, treatment with fenofibrate results in increases in high density lipoprotein (HDL) and apoproteins apoAI and apoAII.

Procetofen for patients

Procetofen Interactions

CAUTION SHOULD BE EXERCISED WHEN COUMARIN ANTICOAGULANTS ARE GIVEN IN CONJUNCTION WITH TRICOR. THE DOSAGE OF THE ANTICOAGULANTS SHOULD BE REDUCED TO MAINTAIN THE PROTHROMBIN TIME/INR AT THE DESIRED LEVEL TO PREVENT BLEEDING COMPLICATIONS. FREQUENT PROTHROMBIN TIME/INR DETERMINATIONS ARE ADVISABLE UNTIL IT HAS BEEN DEFINITELY DETERMINED THAT THE PROTHROMBIN TIME/INR HAS STABILIZED.

HMG-CoA reductase inhibitors

The combined use of TRICOR and HMG-CoA reductase inhibitors should be avoided unless the benefit of further alterations in lipid levels is likely to outweigh the increased risk of this drug combination.

Since bile acid sequestrants may bind other drugs given concurrently, patients should take TRICOR at least 1 hour before or 4-6 hours after a bile acid binding resin to avoid impeding its absorption.

Because cyclosporine can produce nephrotoxicity with decreases in creatinine clearance and rises in serum creatinine, and because renal excretion is the primary elimination route of fibrate drugs including TRICOR, there is a risk that an interaction will lead to deterioration. The benefits and risks of using TRICOR with immunosuppressants and other potentially nephrotoxic agents should be carefully considered, and the lowest effective dose employed.

In vitro studies using human liver microsomes indicate that fenofibrate and fenofibric acid are not inhibitors of cytochrome (CYP) P450 isoforms CYP3A4, CYP2D6, CYP2E1, or CYP1A2. They are weak inhibitors of CYP2C19 and CYP2A6, and mild-to-moderate inhibitors of CYP2C9 at therapeutic concentrations.

Potentiation of coumarin-type anticoagulants has been observed with prolongation of the prothrombin time/INR.

Bile acid sequestrants have been shown to bind other drugs given concurrently. Therefore, fenofibrate should be taken at least 1 hour before or 4-6 hours after a bile acid binding resin to avoid impeding its absorption.

Concomitant administration of fenofibrate (equivalent to 145mg TRICOR) with pravastatin (40 mg) once daily for 10 days has been shown to increase the mean C max and AUC values for pravastatin by 36% (range from 69% decrease to 321% increase) and 28% (range from 54% decrease to 128% increase), respectively, and for 3α-hydroxy-iso-pravastatin by 55% (range from 32% decrease to 314% increase) and 39% (range from 24% decrease to 261% increase), respectively in 23 healthy adults.

A single dose of pravastatin had no clinically important effect on the pharmacokinetics of fenofibric acid.

Concomitant administration of fenofibrate (equivalent to 145 mg TRICOR) with atorvastatin (20 mg) once daily for 10 days resulted in approximately 17% decrease (range from 67% decrease to 44% increase) in atorvastatin AUC values in 22 healthy males. The atorvastatin C max values were not significantly affected by fenofibrate. The pharmacokinetics of fenofibric acid were not significantly affected by atorvastatin.

Procetofen Contraindications

TRICOR is contraindicated in patients who exhibit hypersensitivity to fenofibrate.

TRICOR is contraindicated in patients with hepatic or severe renal dysfunction, including primary biliary cirrhosis, and patients with unexplained persistent liver function abnormality.

TRICOR is contraindicated in patients with preexisting gallbladder disease.

Additional information about Procetofen

Procetofen Indication: For use as adjunctive therapy to diet to reduce elevated LDL-C, Total-C, Triglycerides and Apo B, and to increase HDL-C in adult patients with primary hypercholesterolemia or mixed dyslipidemia (Fredrickson Types IIa and IIb) Mechanism Of Action: Procetofen exerts its therapeutic effects through activation of peroxisome proliferator activated receptor a (PPARa). This increases lipolysis and elimination of triglyceride-rich particles from plasma by activating lipoprotein lipase and reducing production of apoprotein C-III. The resulting fall in triglycerides produces an alteration in the size and composition of LDL from small, dense particles, to large buoyant particles. These larger particles have a greater affinity for cholesterol receptors and are catabolized rapidly. Drug Interactions: Anisindione The fibrate increases the anticoagulant effect Dicumarol The fibrate increases the anticoagulant effect Acenocoumarol The fibrate increases the anticoagulant effect Warfarin The fibrate increases the anticoagulant effect Atorvastatin Increased risk of myopathy/rhabdomyolysis Cerivastatin Increased risk of myopathy/rhabdomyolysis Fluvastatin Increased risk of myopathy/rhabdomyolysis Lovastatin Increased risk of myopathy/rhabdomyolysis Pravastatin Increased risk of myopathy/rhabdomyolysis Simvastatin Increased risk of myopathy/rhabdomyolysis Rosuvastatin Rosuvastatin possibly increases the effect of the fibrate Ursodeoxycholic acid The fibric acid derivative decreases the effect of ursodiol Food Interactions: Increased absorption - take with meals. Generic Name: Fenofibrate Synonyms: Fenofibrato [Inn-Spanish]; Fenofibratum [Inn-Latin]; FNF; Finofibrate Drug Category: Antilipemic Agents; Fribic Acid Derivatives Drug Type: Small Molecule; Approved Other Brand Names containing Fenofibrate: Ankebin; Antara; Elasterate; Elasterin; Fenobrate; Fenogal; Fenotard; Lipanthyl; Lipantil; Lipidex; Lipidil; Lipidil Micro; Lipidil Supra; Lipifen; Lipirex; Lipoclar; Lipofene; Liposit; Lipsin; Lofibra; Luxacor; Nolipax; Procetofen; Proctofene; Protolipan; Secalip; Sedufen; Tricor; Triglide; Absorption: Fenofibrate is well absorbed from the gastrointestinal tract. After absorption, fenofibrate is mainly excreted in the urine in the form of metabolites, primarily fenofibric acid and fenofibric acid glucuronide Toxicity (Overdose): LD 50 =1600 mg/kg (Oral, in mice); Investigated as a teratogen and reproductive hazard. Protein Binding:

99% (Serum protein binding) Biotransformation: Not Available Half Life: 20 hours Dosage Forms of Procetofen: Tablet Oral Capsule Oral Chemical IUPAC Name: propan-2-yl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate Chemical Formula: C20H21ClO4 Fenofibrate on Wikipedia: http://en. wikipedia. org/wiki/Fenofibrate Organisms Affected: Humans and other mammals



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Rino-Clenil Generic Name Beclomethasone Online, Rino-Clenil

Rino-Clenil General Information

Rino-Clenil - Pharmacology:

Unbound corticosteroids cross cell membranes and bind with high affinity to specific cytoplasmic receptors. The result includes inhibition of leukocyte infiltration at the site of inflammation, interference in the function of mediators of inflammatory response, suppression of humoral immune responses, and reduction in edema or scar tissue. The antiinflammatory actions of corticosteroids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.

Rino-Clenil for patients

(beclomethasone dipropionate HFA)

It is important that you read these instructions before using QVAR. Correct and regular use of the inhaler will prevent or lessen the severity of asthma attacks.

1. Remove the plastic cap and be sure there are no foreign objects in the mouthpiece.

2. As with all aerosol medications, it is recommended to prime the QVAR inhaler before using for the very first time after purchase, and in cases where the inhaler has not been used for more than ten days. Prime by releasing two actuations into the air, away from your eyes and face. Be sure the canister is firmly seated in the plastic mouthpiece adapter before each use.

3. BREATHE OUT AS FULLY AS YOU COMFORTABLY CAN. Close your lips around the mouthpiece, keeping your tongue below it.

4. WHILE BREATHING IN DEEPLY AND SLOWLY, PRESS DOWN ON THE CAN WITH YOUR FINGER. When you have finished breathing in, hold your breath as long as you comfortably can (i. e. 5 - 10 seconds).

5. TAKE YOUR FINGER OFF THE CAN and remove the inhaler from your mouth. Breathe out gently.

6. If your physician has told you to take more than one inhalation per treatment repeat steps 3 through 5.

7. You should rinse your mouth with water after treatment.

8. For normal hygiene, the mouthpiece of your inhaler should be cleaned weekly with a clean, dry tissue or cloth. DO NOT WASH OR PUT ANY PART OF YOUR INHALER IN WATER.

9. DISCARD THE CANISTER AFTER the date calculated by your physician or pharma-cist. The correct amount of medication in each inhalation cannot be assured after 100 actuations from the 7. 3 g canister even though the canister is not completely empty. The canister should be discarded when the labeled number of actuations have been used. Before the discard date you should consult your physician to determine whether a refill is needed. It is advisable to keep track of the number of doses taken from the canister to better predict when a refill is necessary.

Just as you should not take extra doses without consulting your physician, you also should not stop taking QVAR without consulting your physician.

IMPORTANT QVAR is preventive therapy for asthma and must be used regularly and at the times your physician has prescribed.

DO NOT CONFUSE QVAR WITH OTHER ASTHMA MEDICATION. QVAR WILL NOT PROVIDE IMMEDIATE RELIEF IF YOU ARE HAVING AN ASTHMA ATTACK.

Your physician will decide whether other medication is needed should you require immediate relief. If you also use another medicine by inhalation, you should consult your physician for instructions on when to use it in relation to using QVAR. If this is the first time you will be using QVAR, it may take from 1 to 4 weeks before you feel the full benefits.

QVAR Inhalation Aerosol canister should only be used with the QVAR Inhalation Aerosol mouthpiece and the mouthpiece should not be used with any other inhalation drug product.

DOSAGE . Use only as directed by your physician.

CONTENTS UNDER PRESSURE Do not puncture. Do not use or store near heat or open flame. Exposure to temperatures above 49?C (120?F) may cause bursting. Never throw container into fire or incinerator.

Keep out of reach of children.

Avoid spraying in eyes.

Store at 25?C (77?F). For optimal results, the canister should be at room temperature when used.

Store QVAR Inhalation Aerosol when not being used, so that the product rests on the concave end of the canister with the plastic actuator on top.

This description is suitable for active ingredient Beclomethasone



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