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Product Description Common use This medicine is a proton pump inhibitor (PPI) used to treat ulcers, heartburn, gastroesophageal reflux, erosive esophagitis, or Zollinger-Ellison syndrome and also ulcers generated by long-term use of non-steroidal anti-inflammatory drugs (NSAIDs). To treat ulcers caused by bacterial infections this medicine may be used in combination with antibiotics such as amoxicillin or clarithromycin. Prilosek significantly alleviates such their symptoms as heartburn, difficulty swallowing, coughing, and sleep problems. Prilosek works by blocking acid production in the stomach. The medicine may be used to treat other conditions diagnosed by your doctor.

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El ISO 45001 sera la nueva norma internacional para los Sistemas de Gestion de Seguridad y Salud Ocupacional. Actualmente hay 50 paises y organizaciones internacionales, incluida la Organizacion Internacional del Trabajo, que participan en este trabajo. El nuevo estandar estaria listo para octubre del 2016.

En octubre de 2013, un comite del proyecto, ISO PC 283, se reunio en Londres para crear el primer borrador de trabajo del ISO 45001. Considerando la OHSAS 18001 – norma britanica internacionalmente reconocida y adoptada para la Salud y Seguridad en el Trabajo – como modelo, este proyecto tambien se alinea con la norma ISO 9001 (Gestion de Calidad) e ISO 14001 (Gestion Ambiental).

Este cambio tendra el siguiente desarrollo: a finales del presente ano (2014) se espera que el proyecto de la norma este disponible para una revision publica; a finales del 2015 se contaria con el Final Draft International Standard (FDIS); y finalmente la publicacion de la norma seria en el 2016. Las empresas tendran tiempo suficiente para adecuarse a la norma.

En esta nueva version se modificaran algunos conceptos fundamentales como ‘riesgo’, ‘lugar de trabajo’, ‘trabajador’. Otro cambio significativo, en comparacion con la norma OHSAS 18001, sera que el enfoque del sistema no estara en la identificacion de peligros, sino en la identificacion de riesgos y sus controles respectivos.

¿Quien se beneficiara con el ISO 45001?

Pequenas, medianas y grandes organizaciones de cualquier sector podran establecer un punto de referencia para la gestion de la salud y seguridad; las politicas y practicas a traves de las diferentes situaciones, paises, culturas y jurisdicciones.

Una vez implementado el sistema, las operaciones se podran alinear con la legislacion nacional e internacional y codigos de conducta; y la mejora de la gestion de riesgo y planificacion de emergencias. El ISO 45001 tambien permitira a las organizaciones establecer y evaluar las medidas de desempeno para los proveedores de servicios. Como resultado, las empresas seran capaces de reducir accidentes, sus costos relacionados, y a la vez garantizaran el bienestar de su empleados, visitantes y vecinos.

El ISO 45001 tambien tendra un impacto directo en la sociedad. Con mas sistemas de salud ocupacional y seguridad internacionalmente reconocidos; el numero de incidentes y accidentes se reduciran, con menor interrupcion de los procesos operativos. Este significa un menor numero de tratamientos de emergencias en el lugar de trabajo y en hospitales.

ISO 45001 Tiempo para un cambio global

El ISO 45001 apoyara nuevas areas de sistemas de gestion para garantizar una mejor compatibilidad y gobernabilidad de los sistemas. Una vez publicada, la norma se aplicara a cualquier organizacion que busque:

Establecer e implementar un sistema de gestion de la seguridad y salud reconocido internacionalmente para reducir o minimizar los riesgos para el personal y otras partes pertinentes.

Mantener y mejorar constantemente su desempeno en salud y seguridad.

Mantener todas las operaciones de acuerdo con las politicas de salud y seguridad que se declaran a una norma internacionalmente reconocida.

Chileprevencion. cl (14 de noviembre de 2014). OHSAS 18.001:2007 Cambia a ISO 45.001 en el ano 2016. www. chileprevencion. cl recuperado el 09 de noviembre de 2015 de http://www. chileprevencion. cl/ohsas-18-0012007-cambia-a-iso-45-001-en-el-ano-2016.html

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Esto es lo que dice la pagina del laboratorio que lo fabrica: Genomma Lab.

Metaboltonics es un producto indicado como auxiliar en el tratamiento de la reduccion, control y mantenimiento de peso en pacientes con sobrepeso moderado, causado por comer en exceso. Metaboltonics no provoca rebote, sin embargo, es importante llevar una dieta saludable y realizar ejercicio, recordando que Metaboltonics solo es un auxiliar para adelgazar, no es la base para hacerlo.

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Genomma Lab ademas de mantenerse preocupado por apoyarte para llegar a tu peso ideal, a traves de Metaboltonics ®, consiente a tu paladar con el delicioso sabor del Cafe Metaboltonics ® Termogenico, elaborado a base de una cuidadosa seleccion de granos de cafe, el cual puede ser disfrutado a cualquier hora del dia.

Despues de un experimentado proceso Genomma Lab logra concentrar en este producto una serie de ingredientes que ayudan a estimular el metabolismo e incrementar la temperatura corporal.

No debes perder de vista que Genomma Lab ha creado para ti este producto teniendo el objetivo de ser solo un auxiliar que te acompanara en el proceso para llegar a tu peso ideal, por tanto, una dieta balanceada y hacer ejercicio es indispensable, ahora es posible llegara a tu peso ideal disfrutando de su sabor y bajando de peso al mismo tiempo, si acostumbras tomar cafe 2 veces al dia esta es la mejor opcion para ti.

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La obesidad es un problema que puede traer consigo consecuencias de importancia, por ello, este producto esta sugerido solo para personas con sobrepeso moderado, si tu padeces obesidad lo sugerido es consultar a tu medico.

Asimismo, te recordamos que este producto esta indicado solo para personas mayores de 18 anos de edad, recuerda que no es un sustituto de tus alimentos.

Capsulas.

Solo basta con tomar 2 capsulas antes de las tres comidas diarias, en conjunto con una alimentacion balanceada, moderada en carbohidratos y grasas, de esta manera podras obtener efectos satisfactorios y duraderos. Puedes llevar a cabo el tratamiento Metabol ® Caps durante 3 meses continuos, descansar un mes y reiniciarlo, sin perder el proceso de llevar una dieta saludable y hacer ejercicio constante durante el “descanso” sin el tratamiento.

Genomma Lab consciente que uno de los problemas que mas aquejan al pais actualmente es la obesidad, por ello, preocupado por tu salud ha creado un auxiliar en el tratamiento de la reduccion, control y mantenimiento del peso en pacientes con sobrepeso moderado, causado por comer en exceso: Metabol ® Caps.

Si has decidido cuidar tu salud y cambiar tu estilo de vida, empezar por tu alimentacion es una excelente opcion, Genomma Lab ha creado la linea Metaboltonics ® como un apoyo durante este proceso. Es importante lleves una dieta saludable y hagas ejercicio de manera constante, recuerda que Metaboltonics es unicamente un auxiliar.

Genomma Lab y Metaboltonics ® unen una formula eficaz que concentra ingredientes de origen natural como lo es el extracto estandarizado de frutas de Garcinia Cambogia y Goma Guar, ayudandote a conseguir tu peso ideal de manera segura.

SEN.

Esta vez Genomma Lab a traves de la linea Metaboltonics ® innova Metabol ® Sen, indicado como auxiliar en la reduccion, mantenimiento y control de peso en personas con sobrepeso exogeno, ademas promueve la utilizacion de grasa acumulada en el organismo ayudando a reducir medidas ya que aumenta la capacidad de oxidacion de los lipidos.

Si sufres de extrenimiento Genomma Lab y Metabol ® Sen te brindan la posibilidad de modular el transito intestinal, coadyuvando en el alivio y la prevencion del estrenimiento y favoreciendo la sensacion de saciedad evitando comer en exceso, es decir, ejerce un efecto laxante suave.

Genomma Lab y Metaboltonics ® unen una formula eficaz que concentra ingredientes de origen natural como lo es el extracto estandarizado de frutas de Garcinia Cambogia, Cassia Angustifolia y Goma Guar, ayudandote a conseguir tu peso ideal de manera segura y sin problemas de estrenimiento.

Debes recordar que Metabol ® Sen, es unicamente un auxiliar que te ayudara en el proceso para conseguir tu peso ideal, lo sugerido es tomar dos capsulas tres veces al dia, media hora antes de cada alimento, debes llevar el tratamiento en conjunto con una alimentacion balanceada y tomar por lo menos 2 litros de agua al dia.

SOS.

Un evento importante y… ¿No te cierra el vestido?

Genomma Lab se preocupa por tu salud y procurar tu imagen, por ello, ha creado para ti Metabol ® SOS que te ayuda a bajar de peso desde el primer dia.

Genomma Lab y Metabol ® SOS unen esfuerzos para crear un concentrado liquido agradable al paladar con mas de 17 componentes funcionales en cantidades necesarias como: proteinas, fibra soluble, fibra dietetica, potasio y carbohidratos por mencionar algunos.

Despues de un proceso de desarrollo Genomma Lab logra innovar en Metaboltonics ® SOS un producto que da resultados en un corto periodo de tiempo, siendo este el inicio de una vida saludable, ya que unido a una dieta sana y ejercicio constante se puede lograr a bajar hasta una talla en tres dias.

Como su nombre lo dice, Metabol ® SOS fue disenado para casos especificos de emergencia; es importante tener en cuenta que el sobrepeso se da a partir de la ingesta de mas calorias de las que el cuerpo necesita, fusionado con la poca actividad fisica, por esto, Metabol ® SOS esta indicado unicamente como auxiliar en el tratamiento para la reduccion de peso, puedes apoyarte con este producto siempre y cuando lleves una dieta saludable y hagas ejercicio constante durante y despues del tratamiento, mismo que dura solo tres dias.

Si has decidido cuidar tu salud y cambiar tu estilo de vida, empezar por tu alimentacion es una excelente opcion, Genomma Lab y Metabol ® SOS te apoyan, recuerda que es solo un auxiliar. Si tienes una emergencia y te encantaria lucir con una talla menos para el evento mas esperado, no lo dudes, toma 30 ml de Metabol ® SOS en 500 ml. de agua, antes de cada alimento y listo.

Te PM.

Ahora puedes quemar grasa mientras duermes, esto es posible gracias a la constante innovacion en la que se concentra Genomma Lab dia a dia para proporcionarte el producto ideal para cubrir las distintas necesidades que requiere cada persona.

Metabol ® Te cuenta con distintos beneficios gracias a sus ingredientes de origen natural, entre los que destacan:

• Lima dulce que proporciona vitaminas y sales minerales como la vitamina C, que es un antioxidante que aumenta la actividad de las defensas naturales, neutraliza las toxinas e incrementa la capacidad de absorcion de hierro.

• Jamaica, que logra metabolizar las grasas a nivel intestinal, funcionando como laxante suave y accion diuretica.

• Tamarindo malvar (Garcinia cambogia), es la parte de la planta utilizada es la pulpa del fruto y su corteza, que contiene diferentes principios activos. El fruto puede desecarse o elaborar extractos fluidos que solo en combinacion con otros principios activos, sirven para controlar el peso.

Estos son solo algunos de los ingredientes naturales que Genomma Lab ha desarrollado dentro de Metabol ® Te para lograr el objetivo final: llegar a tu peso ideal, llevando una dieta saludable y haciendo ejercicio de manera constante, solo basta colocar en una taza de agua caliente 1 saco de Metabol ® Te, dejar reposar por tres minutos y tomarlo antes de dormir.

Como nos pudimos dar cuenta en esta publicacion, este laboratorio nos informa en su pagina todo sobre los productos que tiene actualmente en el mercado pero lamentablemente por lo que la mayoria de la poblacion se guia es por lo que sale en los medios de comunicacion y no busca mas alla, solo les importa bajar de peso de una manera facil, rapida y a un costo no muy elevado.

El problema es que en los comerciales de television todo el panorama es muy alentador, facil y feliz, sin decir en realidad cuales son los efectos secundarios, y como se muestra en el video que subi, no se tiene que hacer ningun tipo de actividad fisica ni cuidarte en ningun sentido, solo haz "trampa" y veras resultados.

Lo que debemos recordar es que si tomas la decision de consumir cualquier producto de estos debe ir en conjunto con una dieta equilibrada, suficiente, inocua, variada y completa y con una actividad fisica de 30-60 min diarios, ademas no debemos olvidar el consumo de agua natural (1.5-2 L al dia).

Estos productos no funcionan en personas con obesidad y son las personas que mas lo consumen.

¿USTEDES QUE OPINAN SOBRE "METABOLTONICS". ¿EN REALIDAD FUNCIONA?

ps io kreo k si aun no lo he probado pero tengo la curiosidad de hacerlo. es solo q el producto no hara todo obviamente tambien necesita su ayudadita por parte de cada uno de los usuarios como lo indican en cada especificacion de los productos. Si hacemos ejercicio, nos alimentamos balanceadamente o en porciones consideradas, tomamos bastante agua, y nos mantenemos activos la mayor parte del dia, claro k el producto nos ayudara. Suerte.

PUES YO COMENCE A TOMAR METABOLTONICS SEN Y SINCERAMENTE SI ME HA FUNCIONADO MI PRINCIPAL SUFRIMIENTO ES EL ESTRENIMIENTO Y REALMENTE YA NO ME SIENTO INFLAMADA, EN CUANTO AL PESO PUES SI HE ESTADO BAJANDO POCO A POCO

es en serio? oye cuantos anos tienes? yo tengo 17, estoy por cumplir los 18, y ya las compre metanoltonics sen pero yo no las compre por que me bajaran de peso, no, yo las compre por el estrenimiento, pero quie bien que si te han funcionado, pero tengo una duda, las pastillas las dejas de tomar despues de cuanto tiempo ?

TENGO UNA DUDA. YO ACABO DE COMPRAR LAS PASTILLAS ME METI AL BUSCADOR DE GOOGLE METABOL TONICS Y APARECIERON MUCHISIMAS PAGINAS DONDE MUCHAS PERSONAS DICEN QUE NO SIRVEN DE NADA QUE ES UN FRAUDE Y QUE DE HECHO GENOMA LAB FUE MULTADO POR PUBLICAR ALGO QUE NO ES CIERTO. POR FA DIGANME QUE ES VERDAD.

si Funciona. yo lo eh tomado y eh obtenido excelentes resultados consumi metabol capsulas y metabol SOS, la ultima vz q los consumi fue hace un ano y medio, Pero ahora los usare de nueva cuenta como axuliar ya q eh comenzado a hacer ejercicio :D de nueva cuenta ahora Provare con Metabol SEN Ahi Despues Les Aviso Si es = de efectivo ;)

llevo tomando metaboltonics sen por un mes, hago minimo una hora de spining y de vez en cuando media hora de pesas, tomo 2 litros de agua al dia, mi comidas son: en la manana un licuado con todos los cereales(avena, trigo, amaranto, etc), en la tarde una buena comida sin tortilla ni refresco y en la noche algun cereal con fruta, eso lo hago de lunes a viernes, he conbinado todo estas cosas y puedo decir que me ha funcionado muy bien, agregandole que padezco del estrenimiento, asi que yo lo recomiendo, claro debemos de tomar en cuenta que cada organismo es diferente, pero si eres constante en el ejercicio, veras los resultados. Saludos.

Si haces ejercicios y todo lo demas q dices q haces no tienes q tomar las pastillas porq de todas maneras te va a funcionar

Tengo 2 semanas tomando metaboltonic y he empezado a sentir un sensacion de piquetes en todo el cuerpo varias veces al dia mucho dolor de cabeza. La sensacion de piquetes es de verdad desesperante lo he suspendido. No me hizo nada al contrario intoxico mi organismo .

Tengo 3 semanas tomando metaboltonics sen y e bajado d peso ahora voy a tomar el cafe haber como me va si se siente el cambio te sientes maa ligera y no tienea problemas para ir al bano

que tal, yo he probado el metabol sos y como no tenia tiempo para la supuesta dieta q te ponen de 3 dias lo que hice fue desayunar comeer y cenar una lata de atun, y al parecer si ha funcionado, aunq claro si dejas de comer tan asi bajas porq bajas

las personas que dicen que estas pastillas no funciona es gente que NO a puesto de su parte y piensan que al tomar pastillas van a perder peso automatico y NO es asi uno tiene que comer saludable y moverse por lo menos 20 minutos diarios ya sea bailae o hacer ejersicio nadar o correr en visicleta

Me podrian informar si realmente Metaboltonics realmente funciona si es mejor k hydroxicute o lipozene en fin si alguien ha tenido la experiencia de poder compararlos gracias

SI FUNCIONA Y MUY BIEN. PERO CLARO CAMBIA TU FORMA DE COMER Y ADELANTE. TE LO DIGO POR EXPERIENCIA TENGO 3 MESES TOMANDOLO (cada caja me dura 5 dias). CUESTA 150 PESOS C/U. PERO VALE LA PENA. LLEVO 12 KILOS. Y ME SIENTO BIEN SIN MAREOS NI DESCOMPENSACION. NI NADA



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Cefadroxil fights bacteria in the body. Cefadroxil is used to treat many different types of bacterial infections such as bronchitis, tonsillitis, ear infections, skin infections, and urinary tract infections.

Use Cefadroxil as directed by your doctor.

Take Cefadroxil by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation. To clear up your infection completely, take Cefadroxil for the full course of treatment. Keep taking it even if you feel better in a few days. Ask your health care provider any questions you may have about how to use Cefadroxil. Drug Class and Mechanism

Cefadroxil is a cephalosporin antibiotic. It works by interfering with the bacteria's cell wall formation. This weakens the cell wall, causing it to rupture, resulting in death of the bacteria.

If you miss a dose of Cefadroxil, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Store Cefadroxil at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Keep Cefadroxil out of the reach of children and away from pets.

Do not use Cefadroxil if:

if you are pregnant, planning to become pregnant, or are breast-feeding; if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement; if you have allergies to medicines, foods, or other substances; if you have a blood clotting disorder, kidney problems, or stomach or bowel problems (e. g. inflammation); if you have had a severe allergic reaction (e. g. a severe rash, hives, breathing difficulties, or dizziness) to a penicillin antibiotic (e. g. amoxicillin) or other beta-lactam antibiotic (e. g. imipenem). Contact your doctor or health care provider right away if any of these apply to you.

Important : Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor. Be sure to use Cefadroxil for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future. Cefadroxil only works against bacteria; it does not treat viral infections (e. g. the common cold). Long-term or repeated use of Cefadroxil may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this. Diabetes patients - Cefadroxil may cause the results of some tests for urine glucose to be wrong. Ask your doctor before you change your diet or the dose of your diabetes medicine. Cefadroxil may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Cefadroxil. Pregnancy and breast-feeding: if you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Cefadroxil while you are pregnant. Cefadroxil is found in breast milk. If you are or will be breast-feeding while you use Cefadroxil. check with your doctor. Discuss any possible risks to your baby.

Possible Side Effects

Check with your doctor if any of these most common side effects persist or become bothersome:

diarrhea; nausea; stomach upset; vomiting. Seek medical attention right away if any of these severe side effects occur:

severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody diarrhea; dark urine; decreased urination; fever, chills, or sore throat; joint pain; red, swollen, or blistered skin; seizures; severe diarrhea; stomach pain or cramps; unusual bruising or bleeding; unusual tiredness or weakness; vaginal itching, odor, or discharge; yellowing of the skin or eyes. More Information

Cefadroxil is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor.

Cefadroxil fights bacteria in the body. Cefadroxil is used to treat many different types of bacterial infections such as bronchitis, tonsillitis, ear infections, skin infections, and urinary tract infections.

Use Cefadroxil as directed by your doctor.

Take Cefadroxil by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation. To clear up your infection completely, take Cefadroxil for the full course of treatment. Keep taking it even if you feel better in a few days. Ask your health care provider any questions you may have about how to use Cefadroxil. Drug Class and Mechanism

Cefadroxil is a cephalosporin antibiotic. It works by interfering with the bacteria's cell wall formation. This weakens the cell wall, causing it to rupture, resulting in death of the bacteria.

If you miss a dose of Cefadroxil, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Store Cefadroxil at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Keep Cefadroxil out of the reach of children and away from pets.

Do not use Cefadroxil if:

if you are pregnant, planning to become pregnant, or are breast-feeding; if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement; if you have allergies to medicines, foods, or other substances; if you have a blood clotting disorder, kidney problems, or stomach or bowel problems (e. g. inflammation); if you have had a severe allergic reaction (e. g. a severe rash, hives, breathing difficulties, or dizziness) to a penicillin antibiotic (e. g. amoxicillin) or other beta-lactam antibiotic (e. g. imipenem). Contact your doctor or health care provider right away if any of these apply to you.

Important : Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor. Be sure to use Cefadroxil for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future. Cefadroxil only works against bacteria; it does not treat viral infections (e. g. the common cold). Long-term or repeated use of Cefadroxil may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this. Diabetes patients - Cefadroxil may cause the results of some tests for urine glucose to be wrong. Ask your doctor before you change your diet or the dose of your diabetes medicine. Cefadroxil may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Cefadroxil. Pregnancy and breast-feeding: if you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Cefadroxil while you are pregnant. Cefadroxil is found in breast milk. If you are or will be breast-feeding while you use Cefadroxil. check with your doctor. Discuss any possible risks to your baby.

Possible Side Effects

Check with your doctor if any of these most common side effects persist or become bothersome:

diarrhea; nausea; stomach upset; vomiting. Seek medical attention right away if any of these severe side effects occur:

severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody diarrhea; dark urine; decreased urination; fever, chills, or sore throat; joint pain; red, swollen, or blistered skin; seizures; severe diarrhea; stomach pain or cramps; unusual bruising or bleeding; unusual tiredness or weakness; vaginal itching, odor, or discharge; yellowing of the skin or eyes. More Information

Cefadroxil is to be used only by the patient for whom it is prescribed. Do not share it with other people. If your symptoms do not improve or if they become worse, check with your doctor.



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Ergot Uses, Side Effects, Interactions And Warnings, Ergotan

ERGOT

Overview

Ergot is a fungus that grows on rye and less commonly on other grasses such as wheat.

Ergot has an interesting history. During the Middle Ages, ergotism, a severe reaction to ergot-contaminated food (such as rye bread), was common and was known as St. Anthony's fire. This illness was often cured by visiting the shrine of St. Anthony, which happened to be in an ergot-free region of France. Additionally, some historians believe that ergot played a role in the Salem witch hunt of 1692. They think that some women in Salem developed peculiar behaviors and accused other women of being witches as a result of eating ergot-contaminated food.

Despite serious safety concerns, ergot has been used as medicine. Women use it to treat excessive bleeding during menstrual periods, at the start of menopause. and before and after miscarriage. They also use ergot after childbirth to expel the placenta and contract the uterus. Historically, ergot was used to speed up labor, but its use was abandoned when people made a connection between the use of ergot and an increased number of stillbirths.

Certain chemicals in ergot are used in prescription medicines.

How does it work?

Ergot contains chemicals that can help reduce bleeding by causing a narrowing of the blood vessels.

Uses

Insufficient Evidence for

Reducing bleeding during menstruation. in menopause. and in connection with miscarriage.

Expelling the placenta after childbirth .

Other conditions.

More evidence is needed to rate the effectiveness of ergot for these uses.

Side Effects

Ergot is UNSAFE . There is a high risk of poisoning, and it can be fatal. Early symptoms of poisoning include nausea. vomiting. muscle pain and weakness. numbness, itching. and rapid or slow heartbeat. Ergot poisoning can progress to gangrene. vision problems, confusion, spasms, convulsions, unconsciousness, and death.

Special Precautions & Warnings:

It is UNSAFE for anyone to use ergot, but some people have extra reasons not to use it:

Pregnancy and breast - feeding . It’s UNSAFE to use ergot. Ergot has many effects that can be harmful during pregnancy and breast - feeding. Don’t use it.

Kidney disease . People with kidney problems are not able to flush ergot out of their bodies well enough. This can cause ergo to build up, and that increases the risk of ergot poisoning.

Liver disease . People with liver problems are not able to remove ergot from their bodies well enough. This can cause ergo to build up, and that increases the risk of ergot poisoning.

Narrowing of the blood vessels that supply the legs and feet (peripheral vascular disease) . Ergot can narrow blood vessels and make this condition worse.

Interactions

Major Interaction: Do not take this combination

Medications for depression (Antidepressant drugs) interacts with ERGOT

Ergot increases a brain chemical called serotonin. Some medications for depression also increase the brain chemical serotonin. Taking ergot along with these medications for depression might increase serotonin too much and cause serious side effects including heart problems, shivering, and anxiety. Do not take ergot if you are taking medications for depression. Some of these medications for depression include fluoxetine (Prozac), paroxetine (Paxil), sertraline (Zoloft), amitriptyline (Elavil), clomipramine (Anafranil), imipramine (Tofranil), and others.

Medications for depression (MAOIs) interacts with ERGOT

Ergot increases a chemical in the brain. This chemical is called serotonin. Some medications used for depression also increase serotonin. Taking ergot with these medications used for depression might cause serious side effects including heart problems, shivering, and anxiety. Some of these medications used for depression include phenelzine (Nardil), tranylcypromine (Parnate), and others.

Moderate Interaction: Be cautious with this combination

Dextromethorphan (Robitussin DM, and others) interacts with ERGOT

Ergot can affect a brain chemical called serotonin. Dextromethorphan (Robitussin DM, others) can also affect serotonin. Taking ergot along with dextromethorphan (Robitussin DM, others) might cause too much serotonin in the brain and serious side effects including heart problems, shivering, and anxiety. Do not take ergot if you are taking dextromethorphan (Robitussin DM, and others).

Ergot Derivatives interacts with ERGOT

Ergot contains the same chemicals as ergot derivatives in prescription medications. Taking ergot supplements with prescription ergot derivatives can increase the effects and side effects of ergot. Some of these ergot derivatives include bromocriptine (Parlodel), dihydroergotamine (Migranal, DHE-45), ergotamine (Cafergot), and pergolide (Permax).

Medications that decrease the breakdown of other medications in the liver (Cytochrome P450 3A4 (CYP3A4) inhibitors) interacts with ERGOT

Some medications are changed and broken down by the liver. Some medications might decrease how quickly the liver breaks down ergot. Taking ergot along with some medications that decrease the break-down of other medications in the liver can increase the effects and side effects of ergot. Before taking ergot, talk to your healthcare provider if you are taking any medications that are changed by the liver. Some medications that might decrease how quickly the liver breaks down ergot include amiodarone (Cordarone), clarithromycin (Biaxin), diltiazem (Cardizem), erythromycin (E-mycin, Erythrocin), indinavir (Crixivan), ritonavir (Norvir), saquinavir (Fortovase, Invirase), and many others.

Meperidine (Demerol) interacts with ERGOT

Ergot increases a chemical in the brain called serotonin. Meperidine (Demerol) can also increase serotonin in the brain. Taking ergot along with meperidine (Demerol) might cause too much serotonin in the brain and serious side effects including heart problems, shivering, and anxiety.

Pentazocine (Talwin) interacts with ERGOT

Ergot increases a brain chemical called serotonin. Pentazocine (Talwin) also increases serotonin. Taking ergot along with pentazocine (Talwin) might increase serotonin too much. Too much serotonin can cause serious side effects including heart problems, shivering, and anxiety. Do not take ergot if you are taking pentazocine (Talwin).

Stimulant drugs interacts with ERGOT

Stimulant drugs speed up the nervous system. Speeding up the nervous system can make you feel jittery and speed up your heartbeat. Ergot might also speed up the nervous system. Taking ergot along with stimulant drugs might cause serious problems including increased heart rate and high blood pressure. Avoid taking stimulant drugs along with ergot. Some stimulant drugs include diethylpropion (Tenuate), epinephrine, phentermine (Ionamin), pseudoephedrine (Sudafed), and many others.

Tramadol (Ultram) interacts with ERGOT

Tramadol (Ultram) can affect a chemical in the brain called serotonin. Ergot can also affect serotonin. Taking ergot along with tramadol (Ultram) might cause too much serotonin in the brain and side effects including confusion, shivering, stiff muscles, and other side effects.

Dosing

The appropriate dose of ergot depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for ergot. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

Conditions of Use and Important Information: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. © Therapeutic Research Faculty 2009.

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Diversification of an investment’s assets by fixed-income sector, arranged by weighting from largest to smallest positions for the date shown. Typically, Portfolio Diversification data is reflective of the fixed income holdings within a portfolio, but may be broader, depending on the product type and/or investment manager. The portfolio diversification may not be representative of the fund’s current or future investments and may change at any time.

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Diversification of an investment’s assets by fixed-income sector, arranged by weighting from largest to smallest positions for the date shown. Typically, Portfolio Diversification data is reflective of the fixed income holdings within a portfolio, but may be broader, depending on the product type and/or investment manager. The portfolio diversification may not be representative of the fund’s current or future investments and may change at any time.

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Top 10 Holdings

2 Top 10 Holdings

The 10 holdings in which this fund had its largest investments, as of the date shown. For Fidelity funds, this information is updated quarterly, with a one-month lag. For other funds, this information is updated based on the disclosure policy of each fund company.

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Top 10 Holdings

The 10 holdings in which this fund had its largest investments, as of the date shown. For Fidelity funds, this information is updated quarterly, with a one-month lag. For other funds, this information is updated based on the disclosure policy of each fund company.

Pennsylvania Econ Dev Fing Solid 5.375%

Berks Cnty Pa Mun Auth 5.5%

Commonwealth Fing Auth 5%

Butler Cnty Pa Hosp Auth 7.25%

Pennsylvania St Higher Edl Fac Fixed 5%

Philadelphia Pa Hosps & Higher Hos 6.65%

Chester Cnty Pa Go Nts An 5%

Allegheny Cnty Pa Port Auth 5.75%

Pennsylvania St Tpk Commn Tpk Rev Bds 5%

Pennsylvania St Higher Edl Fac Rev Bd 5%

% of Total Portfolio

Total # of holdings: 181 as of 7/31/2016

Credit Quality

2 Credit Quality_Help Text

For Fidelity Bond Funds & Multi-Asset Class Funds with a fixed income component, please see page footnote for Credit Quality methodology.

For Non-Fidelity Funds: Data provided by Morningstar, who surveys fund companies for the credit rating information on the funds underlying securities holdings on a periodic basis. Morningstar instructs fund companies to only use ratings that have been assigned by a Nationally Recognized Statistical Rating Organizations (NRSRO). If three or more NRSROs have rated the same security differently, fund companies are to report the middle rating; if two NRSROs have rated a security differently, fund companies are to report the lowest rating; if only one NRSRO has rated a security, fund companies are to report that rating. Securities not rated by an NRSRO are to be included in the Not Rated category. All U. S. Government Securities are included in the AAA category. If an NRSRO provides Morningstar with a short-term issue credit rating rather than a traditional fixed income credit rating for a cash security, Morningstar will translate that short-term issue rating to an equivalent fixed income credit rating as reflected in the Credit Quality Breakdown chart. Morningstar is not itself an NRSRO nor does it issue a credit rating on the fund or any securities held by the fund. For Money Market Funds: A Tier 1 security is a money market fund eligible security whose credit rating falls in the highest short-term rating category of the Nationally Recognized Statistical Rating Organizations. An unrated security is Tier 1 if it represents comparable quality to a rated security as defined by SEC Rule 2a-7 under the Investment Company Act of 1940. A Tier 2 Security is a money market fund eligible security that is not a Tier 1 security.

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Credit Quality_Help Text

For Fidelity Bond Funds & Multi-Asset Class Funds with a fixed income component, please see page footnote for Credit Quality methodology.

For Non-Fidelity Funds: Data provided by Morningstar, who surveys fund companies for the credit rating information on the funds underlying securities holdings on a periodic basis. Morningstar instructs fund companies to only use ratings that have been assigned by a Nationally Recognized Statistical Rating Organizations (NRSRO). If three or more NRSROs have rated the same security differently, fund companies are to report the middle rating; if two NRSROs have rated a security differently, fund companies are to report the lowest rating; if only one NRSRO has rated a security, fund companies are to report that rating. Securities not rated by an NRSRO are to be included in the Not Rated category. All U. S. Government Securities are included in the AAA category. If an NRSRO provides Morningstar with a short-term issue credit rating rather than a traditional fixed income credit rating for a cash security, Morningstar will translate that short-term issue rating to an equivalent fixed income credit rating as reflected in the Credit Quality Breakdown chart. Morningstar is not itself an NRSRO nor does it issue a credit rating on the fund or any securities held by the fund. For Money Market Funds: A Tier 1 security is a money market fund eligible security whose credit rating falls in the highest short-term rating category of the Nationally Recognized Statistical Rating Organizations. An unrated security is Tier 1 if it represents comparable quality to a rated security as defined by SEC Rule 2a-7 under the Investment Company Act of 1940. A Tier 2 Security is a money market fund eligible security that is not a Tier 1 security.

Portfolio Data

For Equity Funds, turnover rate is a measure of the fund’s trading activity calculated by dividing total purchases or sales of portfolio securities (whichever is lower) by the fund’s net assets. For the fixed income investments, duration estimates how much a bond fund’s price will change with a change in comparable interest rates. Weighted average maturity is a weighted average of all the maturities of the securities held in a fund. WAM can be used as a measure of sensitivity to interest rate changes and markets changes. For money market funds, weighted average life is the weighted average of the life of the securities held in a fund or portfolio and can be used as a measure of sensitivity to changes in liquidity and/or credit risk. Generally, the higher the value, the greater the sensitivity.

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Portfolio Data

For Equity Funds, turnover rate is a measure of the fund’s trading activity calculated by dividing total purchases or sales of portfolio securities (whichever is lower) by the fund’s net assets. For the fixed income investments, duration estimates how much a bond fund’s price will change with a change in comparable interest rates. Weighted average maturity is a weighted average of all the maturities of the securities held in a fund. WAM can be used as a measure of sensitivity to interest rate changes and markets changes. For money market funds, weighted average life is the weighted average of the life of the securities held in a fund or portfolio and can be used as a measure of sensitivity to changes in liquidity and/or credit risk. Generally, the higher the value, the greater the sensitivity.

Fixed Income StyleMap ® *

5 Fixed Income StyleMap ® *

StyleMap ® depictions of mutual fund characteristics are produced using data and calculations provided by Morningstar, Inc. StyleMaps SM estimate characteristics of a fund’s fixed income holdings over two dimensions: credit quality and interest rate sensitivity. Current StyleMap characteristics are calculated each time Morningstar receives updated portfolio holdings from a fund and are denoted with a dot. Historical StyleMap characteristics are calculated for the shorter of either the past 3 years or the life of the fund, and are represented by the shading of the box(es) previously occupied by the dot. StyleMap characteristics represent an approximate profile of the fund’s holdings, are based on historical data, and are not predictive of the fund’s future investments. Although the data are gathered from reliable sources, accuracy and completeness cannot be guaranteed.

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Fixed Income StyleMap ® *

StyleMap ® depictions of mutual fund characteristics are produced using data and calculations provided by Morningstar, Inc. StyleMaps SM estimate characteristics of a fund’s fixed income holdings over two dimensions: credit quality and interest rate sensitivity. Current StyleMap characteristics are calculated each time Morningstar receives updated portfolio holdings from a fund and are denoted with a dot. Historical StyleMap characteristics are calculated for the shorter of either the past 3 years or the life of the fund, and are represented by the shading of the box(es) previously occupied by the dot. StyleMap characteristics represent an approximate profile of the fund’s holdings, are based on historical data, and are not predictive of the fund’s future investments. Although the data are gathered from reliable sources, accuracy and completeness cannot be guaranteed.

Interest Rate Sensitivity

Medium Quality Moderate Sensitivity

Hold securities with a medium asset-weighted average credit rating and a moderate sensitivity to interest rate changes as defined by the fund's effective duration, both according to Morningstar's rating system.

*100.39% Fund Assets Covered

Country Diversification

2 Country Diversification

Holdings are presented to illustrate examples of the countries or regions which the fund may invest, and may not be representative of the fund’s current or future investments. Percentages are displayed for the top countries or regions as of the date stated. Percentages shown describe the portion of the fund’s total net assets, unless otherwise stated.

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Country Diversification

Holdings are presented to illustrate examples of the countries or regions which the fund may invest, and may not be representative of the fund’s current or future investments. Percentages are displayed for the top countries or regions as of the date stated. Percentages shown describe the portion of the fund’s total net assets, unless otherwise stated.

Fund Facts

This section provides specific information about a fund, such as the day it first opened to new investors, its fiscal year end, and its ticker, which is used for identification purposes.

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Fund Facts

This section provides specific information about a fund, such as the day it first opened to new investors, its fiscal year end, and its ticker, which is used for identification purposes.

The "Mutual Funds" area at the top of each page allows access to mutual fund holdings with individual and joint Fidelity non-retirement accounts. Individual stock positions, ETFs and 529 funds are not available through this view. For the full list of your holdings visit Portfolio Summary .

Mutual Funds are priced as of the previous business day's market close when the market is open. Mutual fund positions are priced as of the official market close (typically 4p. m.) and prices are generally available between 5 p. m. and 6p. m.

Watch a brief video to learn about using the new mutual fund library to evaluate funds

? 2016 Morningstar, Inc. All rights reserved. The Morningstar information contained herein: (1) is proprietary to Morningstar and/or its content providers; (2) may not be copied or redistributed; and (3) is not warranted to be accurate, complete or timely. Neither Morningstar nor its content providers are responsible for any damages or losses arising from any use of this information. Fidelity does not review the Morningstar data and, for fund performance, you should check the fund's current prospectus or other product materials for the most up-to-date information concerning applicable loads, fees and expenses.

1. Transaction Fee:

A transaction fee is similar to a brokerage fee or commission which you pay when you buy or sell a stock. For some funds available through Fidelity you are required to pay a transaction fee. However, you will not pay a sales load on Transaction Fee (TF) funds. You will only be charged a transaction fee when you buy a FundsNetwork TF fund, not when you sell one. All other fees and expenses described in a fund's prospectus still apply. You can choose to buy or sell shares directly from the fund itself or its principal underwriter or distributor without paying a transaction fee to Fidelity.

Online Transaction Fees: $49.95 for most funds. Certain funds will have a transaction fee of $75. To identify any applicable transaction fees associated with the purchase of a given fund, please refer to the "Fees and Distributions" tab.

Fidelity Automated Service Telephone (FAST): 25% off representative-assisted rates, Maximum: $187.50, Minimum:$75 Representative-Assisted: 0.75% of principal, Maximum: $250, Minimum: $100 Automatic Investment: $5 per transaction, after the initial investment.

A sales charge added to the price of the fund. Funds have different sales charge structures, including front-end loads, back-end loads (deferred), and no loads. Sales loads can either be charged when a fund is purchased, commonly known as a front-end load, or when a fund is sold, known as a deferred load. Not all funds charge a load. Refer to the Loads, Expense and Minimums section of the fund's prospectus for details on these amounts. Although no load funds do not have a front-end or deferred load, they may incur other fees, such as a 12b-1 fee.

2. Any holdings, asset allocation, diversification breakdowns or other composition data shown are as of the date indicated and are subject to change at any time. They may not be representative of the fund's current or future investments. Some breakdowns may be intentionally limited to a particular asset class or other subset of the fund's entire portfolio, particularly in multi-asset class funds where the attributes of the equity and fixed income portions are different.

Under the asset allocation section, international (or foreign) assets may be reported differently depending on how an investment options reports its holdings. Some do not report international (or foreign) holdings here, but instead report them in a "Regional Diversification" section. Some report them in this section as an to the equity, bond and other allocation shown. Others report international (or foreign) holding as a subset of the equity and bond allocations shown. If the allocation without the foreign component (or round to) 100%, then international (or foreign) is a subset of the equity and bond percentage shown.

3. The current yield reflects the current earnings of the fund, while the total return refers to a specific past holding period. The 7-Day Yield is the average income return over the previous seven days, assuming the rate stays the same for one year and that dividends are reinvested. It is the Fund's total income net of expenses, divided by the total number of outstanding shares and includes any applicable waiver or reimbursement.

4. A standard yield calculation developed by the Securities and Exchange Commission for bond funds. The yield is calculated by dividing the net investment income per share earned during the 30-day period by the maximum offering price per share on the last day of the period. The yield figure reflects the dividends and interest earned during the 30-day period, after the deduction of the fund's expenses. It is sometimes referred to as "SEC 30-Day Yield" or "standardized yield".

5. Fixed Income StyleMap ? StyleMap ? depictions of mutual fund characteristics are produced using data and calculations provided by Morningstar, Inc. StyleMaps SM estimate characteristics of a fund's fixed income holdings over two dimensions: credit quality and interest rate sensitivity. Current StyleMap characteristics are calculated each time Morningstar receives updated portfolio holdings from a fund and are denoted with a dot. Historical StyleMap characteristics are calculated for the shorter of either the past 3 years or the life of the fund, and are represented by the shading of the box(es) previously occupied by the dot. StyleMap characteristics represent an approximate profile of the fund's holdings, are based on historical data, and are not predictive of the fund's future investments. Although the data are gathered from reliable sources, accuracy and completeness cannot be guaranteed.

Generally, data on Fidelity mutual funds is provided by FMR, LLC, Morningstar ratings and data on non-Fidelity mutual funds is provided by Morningstar, Inc. and data on non-mutual fund products is provided by the product's investment manager, trustee or issuer or the plan sponsor whose plan is offering the product to participants. Although Fidelity believes the data gathered from these third-party sources is reliable, it does not review such information and cannot warrant it to be accurate, complete or timely. Fidelity is not responsible for any damages or losses arising from any use of this third-party information.

Before investing, consider the investment objectives, risks, charges and expenses of the fund or annuity and its investment options. Contact Fidelity for a free prospectus and, if available, summary prospectus containing this information. Read it carefully.



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Imperacin, Imperacin

Sumycin is used for treating infections caused by certain bacteria. Sumycin is a tetracycline antibiotic. It works by slowing the growth of sensitive bacteria by interfering with the production of proteins needed by the bacteria to grow. Slowing the bacteria's growth allows the body's defense mechanisms to destroy them.

Use Sumycin as directed by your doctor.

Take Sumycin by mouth on an empty stomach at least 1 hour before or 2 hours after eating.

Take Sumycin with a full glass of water (8 oz/240 mL). Do not lie down for 30 minutes after taking Sumycin.

If you also take antacids containing aluminum, calcium, or magnesium; preparations containing bismuth, iron, zinc, or sodium bicarbonate; or calcium rich foods (eg, milk, dairy products, calcium-enriched juices), do not take them within 2 to 3 hours before or after taking Sumycin. Check with your doctor if you have questions.

To clear up your infection completely, take Sumycin for the full course of treatment. Keep taking it even if you feel better in a few days.

If you miss a dose of Sumycin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Sumycin.

Store Sumycin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C), in a tightly closed, light-resistant container. Keep away from heat, moisture, and light. Do not store in the bathroom. Keep Sumycin out of the reach of children and away from pets.

Active Ingredient: Tetracycline hydrochloride.

Do NOT use Sumycin if:

you are allergic to any ingredient in Sumycin or other tetracycline antibiotics (eg, doxycycline)

you are taking acitretin or methoxyflurane.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Sumycin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have diarrhea, a stomach infection, or kidney problems.

Some medicines may interact with Sumycin. Tell your health care provider if you are taking any other medicines, especially any of the following:

Acitretin or isotretinoin because side effects, such as increased pressure in the fluid surrounding the brain, may occur

Digoxin, methotrexate, methoxyflurane, or oral anticoagulants (eg, warfarin) because the risk of their side effects may be increased by Sumycin

Atovaquone, lithium, oral contraceptives (birth control pills), or penicillins (eg, amoxicillin) because their effectiveness may be decreased by Sumycin.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Sumycin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Sumycin may cause dizziness or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Sumycin with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.

Be sure to use Sumycin for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.

Sumycin may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Sumycin. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.

Do not use after expiration date. Outdated medicine is highly toxic to the kidneys.

Long-term or repeated use of Sumycin may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.

Hormonal birth control (eg, birth control pills) may not work as well while you are using Sumycin. To prevent pregnancy, use an extra form of birth control (eg, condoms).

Lab tests may be performed while you use Sumycin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use of Sumycin in children may cause permanent discoloring of the teeth.

Sumycin should be used with extreme caution in children younger 8 years; safety and effectiveness in these children have not been confirmed.

Pregnancy and beast-feeding: Sumycin has been shown to cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Sumycin while you are pregnant. Sumycin is found in breast milk. Do not breast-feed while taking Sumycin.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Black hairy tongue; blurred vision; bulky loose stools; diarrhea; difficulty swallowing; fever; headache; hives; hoarseness; indigestion; inflammation or redness of tongue; joint pain; loss of appetite; mouth sores; nausea; rash; sensitivity to sunlight; sore throat; stomach pain; swelling and itching of the rectum.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); infection (fever, chills, sore throat); itching; nausea; severe skin reaction to the sun; vaginal irritation or discharge; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.



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Cefalexina, Compr, Cefalexinum

CEFALEXINA, compr. | cefalexinum

Indicatii:

Produsul se recomanda in tratamentul urmatoarelor infectii: Infectii ale tractului genito-urinar, inclusiv prostatita acuta, cauzate de urmatorii germeni: E. coli, Proteus mirabilis, Klebsiella. Infectii ale pielii si ale tesuturilor moi cauzate de stafilococi si streptococi. Infectii ale oaselor si articulatiilor, cauzate de stafilococi si Proteus mirabilis. Infectii la nivelul tractului respirator (bronsita, traheita, rinofaringita, sinuzita etc.) cauzate de S. pneumoniae si streptococi betahemolitici din grupa A. Otite medii cauzate de S. pneumoniae, H. influenzae, stafilococi, streptococi, Neisseria catarrhalis. Infectii dentare cauzate de stafilococi si streptococi. In cazul infectiilor grave si generalizate se recomanda administrarea Cefalexinei parenteral.

Contraindicatii:

Alergii la antibiotice din grupul cefalosporinelor. In cazul alergiilor la penicilina se va tine cont de riscul alergiilor incrucisate.

Administrare:

Adulti: Doza zilnica totala este intre 1 g si 4 g, fractionata in mai multe prize. Posologia recomandata in mod normal este de 250 mg la fiecare 6 ore. In cazul infectiilor curente si fara complicatii ale tractului urinar, ale pielii si ale tesuturilor moi, ca si in cazul faringitelor sau amigdalitelor streptococice, se pot administra 500 mg la fiecare 12 ore. Pentru tratarea cazurilor grave sau a celor cauzate de germeni mai putin sensibili sunt necesare doze mai mari, de pana la 4 g/zi. Copii: doza recomandata in mod normal este de 25 - 50 mg/kg/zi, fractionata in mai multe prize. Doza poate fi dublata in cazul infectiilor grave, sau a celor cauzate de germenii mai putin sensibili. In cazul infectiilor curente si fara complicatii ale tractului urinar, ale pielii si ale tesuturilor moi, ca si in cazul faringitelor sau amigdalitelor streptococice, doza cotidiana totala poate fi fractionata in doua prize egale, administrate la intervale de 12 ore. Studiile clinice au demonstrat ca tratamentul otitei medii necesita o doza cotidiana de 75 - 100 mg/kg, fractionate in patru prize.

Compozitie:

Produsul se prezinta sub forma de pulbere granulata conditionata in capsule operculate continand cefalexina monohidrat echivalent cu 250 mg, respectiv 500 mg cefalexina anhidra per capsula.

Precautii:

Medicamentul se va administra cu prudenta in cazul prezentei urticariei, eruptiilor cutanate, precum si la pacientii astmatici. Se va utiliza cu precautie in cazul afectiunilor gastro-intestinale, in special a colitei. Pacientele care iau contraceptive trebuie atentionate ca efectul acestora se diminueaza la administrarea de Cefalexina. In cazul unor tulburari gastro-intestinale grave, insotite de stari de voma si diaree, se recomanda administrarea parenterala. Daca diareea se prelungeste, se poate presupune instaurarea unei colite pseudomembranoase datorata tratamentului, si acesta trebuie intrerupt. Utilizarea prelungita a Cefalexinei poate duce la proliferarea germenilor rezistenti. Sarcina si alaptare: Nu a fost suficient evaluata eficacitatea si siguranta in folosire a acestui produs la femeile insarcinate sau care alapteaza; prin urmare se va evita administrarea medicamentului in aceste cazuri. La patru ore de la administrarea Cefalexinei, s-a gasit in laptele matern un nivel de 4 mg/ml; dupa opt ore nu s-a mai detectat nici o urma de cefalexina. In lipsa unor informatii suficiente privind efectul medicamentului asupra laptelui matern, se recomanda intreruperea alaptarii pe perioada tratamentului.

Reactii adverse:

Manifestari alergice, in special la pacientii cu hiper-sensibilitate la cefalosporine (urticarie, eruptii cutanate). Tulburari digestive (greturi, voma, diaree). Ameteli, senzatie de oboseala si dureri de cap, care dispar la intreruperea tratamentului.

Medicamente alternative (cu aceeasi substanta activa):

Medicamente cu indicatii asemanatoare (din aceeasi clasa):



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Amlodipino - Drug Review Dosage, Side Effects, Action, Buy Amlodipino, Amlodipino

Amlodipino

Amlodipino review

Amlodipino is a channel blocker, more specifically it is a calcium channel blocker that is used mainly for chest pain. also called angina, and high blood pressure. Since calcium makes the arteries contract and causes the arteries to become narrow, by blocking the calcium, Amlodipino helps the blood flow into the heart more smoothly. It also relaxes the muscle in the arteries to help the heart pump blood. Additionally, it reduces blood pressure and increases blood flow to other parts of the body. Chest pain is greatly reduced by the extra supply of blood to the heart. Usually the medicament of choice when treating high blood pressure and angina, Amlodipino helps the heart deal with high blood pressure by increasing the blood flow and relaxing the muscles, this way the heart doesn't have to work so hard.

Any prescription or non-prescription medicaments should be reported to your doctor before taking Amlodipino. Prescription medicaments for HIV or acquired immunodeficiency syndrome, prostate problems, seizures, fungal infections, bacterial infections. or diuretics might be harmful to your body if taken with Amlodipino. Even herbal medicaments, natural supplements, large amounts of calcium, or even vitamins might affect the effectiveness of the medicament. Also, if the patient has ever had liver illness or heart illness it might have left those organs weakened and thus more susceptible to the harmful Amlodipino effects. Inform your treating physician immediately if any of those illnesss have occurred. Patients who are already taking nitroglycerin for angina don't have to stop taking it when Amlodipino is prescribed, nitroglycerin can be taken with Amlodipino without any harmful effects.

Some side effects that can occur while taking Amlodipino are: edema, dizziness. headache. upset stomach. rashes, drowsiness, irregular heartbeat. swelling of the hands and feet, and excessive tiredness. These are negligible side effects that are common with most medicaments. Patients must be careful not to drive after taken Amlodipino because the drowsiness that comes with taking the medicament might cause problems on the road. Some more serious side effects are severe chest pain, irregular heartbeat and fainting. If any of these occur then it is best to go to a hospital immediately.

No concrete evidence suggests that Amlodipino is harmful to pregnant women, but if you are pregnant or become pregnant during the treatment please inform your doctor as a safety measure. Only take Amlodipino if the benefits outweigh the probable danger to the fetus. A warning to mothers: researchers have not yet confirmed if the medicament is passed on through breast milk, so as a precaution, nursing mothers should stop breastfeeding while on Amlodipino.

Amlodipino is commonly sold under the names Norvasc and Istin. It is usually sold as pills in 5-10 mg tablets. Doctors usually prescribe 5mg at the beginning of treatment then gradually increase the dosage as they see fit. Amlodipino usually is in effect for a full 24 hours, so the dosage is typically daily. A tip when using this medicament is to have a low-sodium diet because it helps the medicament with its course of action.

Amlodipino has the following structural formula:

• Molecular formula of amlodipino is C20H25ClN2O5 • Chemical IUPAC Name is methylethyl2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6- methyl-1,4-dihydropyridine-3,5-dicarboxylate • Molecular weight is 408.876 g/mol • Amlodipino available. 2.5mg tablets, 5mg tablets, 10mg tablets

Generic name: Amlodipine



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Ergotamine Medical Facts From, Ergotamina

ergotamine

What is ergotamine?

Ergotamine is in a group of drugs called ergot alkaloids (ER-got AL-ka-loids). It works by narrowing the blood vessels around the brain. Ergotamine also affects blood flow patterns that are associated with certain types of headaches.

Ergotamine is used to treat a migraine type headache.

This medication will only treat a headache that has already begun. It will not prevent migraine headaches or reduce the number of attacks.

Ergotamine should not be used to treat common tension headaches or any headache that seems to be different from your usual migraine headaches.

Ergotamine may also be used for purposes not listed in this medication guide.

What is the most important information I should know about ergotamine?

This medication can harm an unborn baby or a nursing baby. Do not take ergotamine if you are pregnant or breast-feeding.

Do not take this medication if you are allergic to ergotamine or other ergot medicines, or if you have a history of heart disease, angina (chest pain), blood circulation problems, history of a heart attack or stroke, coronary artery disease, uncontrolled high blood pressure, severe liver or kidney disease, or a serious infection.

Using certain medications together with ergotamine can cause even greater decreases in blood flow than ergotamine used alone, which can lead to dangerous side effects. Tell your doctor about all other medications you are using.

Also tell your doctor about all of your medical conditions, especially high blood pressure, liver or kidney disease, or risk factors for coronary artery disease (diabetes, high blood pressure or cholesterol, menopause or hysterectomy, smoking, taking birth control pills, being overweight, having a family history of coronary artery disease, or being a man older than 40).

This medication will only treat a headache that has already begun. It will not prevent headaches or reduce the number of attacks.

Never take more than your prescribed dose of ergotamine. An overdose can be fatal.

What should I discuss with my healthcare provider before taking ergotamine?

Do not take this medication if you are allergic to ergotamine or similar medications such as Cafergot, D. H.E. 45, Migergot, Migranal, or Methergine.

Do not take ergotamine if you are pregnant or breast-feeding, or if you have:

a history of heart disease, angina (chest pain), blood circulation problems, or history of a heart attack or stroke;

coronary artery disease or "hardening of the arteries";

uncontrolled high blood pressure;

severe liver disease;

severe kidney disease; or

a serious infection called sepsis.

Using certain medications together with ergotamine can cause even greater decreases in blood flow than ergotamine used alone, which can lead to dangerous side effects. Do not take ergotamine if you are also using any of the following medications:

conivaptan (Vaprisol), imatinib (Gleevec), isoniazid (for treating tuberculosis), or nefazodone (an antidepressant);

diclofenac (Arthrotec, Cataflam, Voltaren, Flector Patch, Solareze);

clarithromycin (Biaxin), erythromycin (E. E.S. EryPed, Ery-Tab, Erythrocin), or telithromycin (Ketek);

clotrimazole (Mycelex Troche), itraconazole (Sporanox), ketoconazole (Extina, Ketozole, Nizoral, Xolegal), or voriconazole (Vfend);

heart or blood pressure medication such as diltiazem (Cardizem, Dilacor, Tiazac), nicardipine (Cardene), quinidine (Quin-G), or verapamil (Calan, Covera, Isoptin, Verelan); or

HIV/AIDS medicine such as atazanavir (Reyataz), delavirdine (Rescriptor), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), saquinavir (Invirase, Fortovase), or ritonavir (Norvir).

Ergotamine can cause rare but serious side effects on the heart, including heart attack or stroke. To make sure you can safely take ergotamine, tell your doctor if you have any of these other conditions:

high blood pressure;

kidney disease; or

coronary artery disease (or risk factors that include diabetes, menopause, smoking, being overweight, having high blood pressure or high cholesterol, having a family history of coronary artery disease, being older than 40 and a man, or being a woman who has had a hysterectomy).

FDA pregnancy category X. Ergotamine can cause birth defects. Do not use if you are pregnant. Tell your doctor right away if you become pregnant during treatment. Use an effective form of birth control while you are using this medication.

Ergotamine can pass into breast milk and may harm a nursing baby. Ergotamine may also decrease milk production. Do not use if you are breast-feeding a baby.

How should I take ergotamine?

Take exactly as prescribed by your doctor. Never take more than your prescribed dose of ergotamine. Follow the directions on your prescription label. Tell your doctor if the medicine seems to stop working as well in treating your migraine attacks. Ergotamine is not for daily use.

Take the first dose of ergotamine as soon as you notice headache symptoms, or after an attack has already begun. Place 1 ergotamine tablet under your tongue.

If your headache does not completely go away, you may take a second tablet after at least 30 minutes have passed, and a third tablet if needed after another 30 minutes have passed (a total of 3 tablets).

If you still have migraine symptoms after taking a total of 3 tablets, call your doctor. Do not take more than a total of 3 tablets in any 24-hour period. Do not take more than a total of 5 tablets over a period of 7 days.

Do not give this medication to anyone else, even if they have the same headache symptoms you have. Ergotamine can be dangerous if it is used to treat headache in a person who has not been diagnosed by a doctor as having true migraine headaches.

Store at room temperature away from moisture, heat, and light. Do not take any stored ergotamine if the expiration date on the label has passed.

What happens if I miss a dose?

Since ergotamine is taken only when needed, you are not likely to miss a dose.

Do not take more than 3 ergotamine tablets per day or more than 5 tablets per week.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of ergotamine can be fatal.

Overdose can cause vomiting, confusion, drowsiness, weak pulses in your arms and legs, numbness and tingling or pain in your hands or feet, blue-colored fingers or toes, fainting, and seizure (convulsions).

What should I avoid while taking ergotamine?

Do not take ergotamine within 24 hours before or after using another migraine headache medicine, including:

dihydroergotamine (D. H.E. 45, Migranal), caffeine and ergotamine (Cafergot, Ercaf, Wigraine), ergonovine (Ergotrate), methylergonovine (Methergine), methysergide (Sansert); or

almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), sumatriptan (Imitrex), rizatriptan (Maxalt, Maxalt-MLT), or zolmitriptan (Zomig).

Grapefruit and grapefruit juice may interact with ergotamine and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.

Ergotamine side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop taking ergotamine and call your doctor at once if you have a serious side effect such as:

sudden numbness or weakness, especially on one side of the body;

sudden headache, confusion, problems with vision, speech, or balance;

fast or slow heart rate;

muscle pain in your arms or legs;

numbness or tingling and a pale or blue-colored appearance in your fingers or toes;

severe pain in your stomach or lower back;

urinating less than usual or not at all;

swelling or itching in any part of your body;

cough with stabbing chest pain and trouble breathing; or

dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).

Less serious side effects may include:

dizziness, spinning sensation;

nausea, vomiting; or

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Ergotamine dosing information

Usual Adult Dose for Migraine:

Initial dose: 2 mg under the tongue given as quickly as possible after the first symptom of headache.

Another 2 mg tablet may be taken at 30 minute intervals if necessary, but dosage must not exceed three tablets in any 24-hour period. Total weekly dosage should not exceed five tablets (10 mg). Ergotamine sublingual tablets should not be used for chronic daily administration.

What other drugs will affect ergotamine?

Many drugs can interact with ergotamine. Below is just a partial list. Talk with your doctor before taking ergotamine if you are also taking:

birth control pills;

cold or allergy medications;

nicotine (Nicoderm, Nicorette);

diet pills, stimulants, or medication to treat ADHD (such as Ritalin or Adderall);

an antidepressant such as fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), nefazodone (Serzone), paroxetine (Paxil), sertraline (Zoloft), and others;

an antibiotic such as metronidazole (Flagyl);

clotrimazole (Mycelex Troche), fluconazole (Diflucan), or other antifungal medication;

nitroglycerin or other nitrate medicines such as isosorbide (Isordil, Dilatrate, Imdur, Monoket); or

heart or blood pressure medication such as atenolol (Tenormin), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), and others.

This list is not complete and other drugs may interact with ergotamine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More about ergotamine

Consumer resources

Professional resources

Related treatment guides

Where can I get more information?

Your pharmacist can provide more information about ergotamine.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 5.02. Revision Date: 2010-12-15, 5:01:39 PM.

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Dikloferol Rezeptfrei Kaufen ? Qualitat; ? Mit Niedrigen Preisen; ? Lieferung, Dikloferol

Diclofenac ist in erster Linie fur die Behandlung von Entzundungen und Schmerzen durch Erkrankungen wie rheumatoide Arthritis, Osteoarthritis, Spondylitis ankylosans und verursacht sind. Es ist auch wirksam bei der Behandlung von Weichteil-Entzundungen durch Tendinitis und Bursitis und Behandlung von Dysmenorrhoe (Menstruationsschmerzen). Diclofenac ist ein NSAR. NSAIDs behandeln die Symptome von Schmerzen und Entzundungen. Sie behandeln nicht die Krankheit, die diese Symptome verursacht.

Verwenden Sie Diclofenac wie von Ihrem Arzt verordnet!

Nehmen Sie Diclofenac durch den Mund. Es kann mit der Nahrung aufgenommen werden, wenn es Ihren Magen belastet. Taking it mit dem Essen kann nicht das Risiko von Magen-oder Darmprobleme (zB Blutungen, Geschwure). Sprechen Sie mit Ihrem Arzt oder Apotheker, wenn Sie andauernde Magenbeschwerden haben.

Nehmen Sie Diclofenac mit einem vollen Glas Wasser (8 oz/240 mL), wie von Ihrem Arzt verordnet wurde.

Wenn Sie eine Dosis von Diclofenac, bringen Sie es so bald wie moglich. Wenn es fast Zeit fur Ihre nachste Dosis ist, uberspringen Sie die vergessene Dosis und gehen Sie zuruck zu Ihrem regelma?igen Dosierungsschema. Nehmen Sie nicht 2 Dosen auf einmal.

Fragen Sie Ihren Arzt Fragen konnen Sie sich daruber, wie Diclofenac oder wieder einnehmen.

Shop Diclofenac bei 77 Grad F (25 Grad C). Kurze Lagerung bei Temperaturen zwischen 59 und 86 Grad F (15 und 30 Grad C) ist nicht gestattet. Lager weg von der Hitze, Feuchtigkeit und Licht. Nicht im Bad. Halten Sie Diclofenac au?erhalb der Reichweite von Kindern und weg von Haustieren.

Verwenden Sie KEINE Diclofenac, wenn:

Sie sind allergisch gegen jegliche Zutaten in Diclofenac oder Rinder (Kuh)-Protein

Sie haben eine schwere allergische Reaktion (z. B. schweren Hautausschlag, Nesselsucht, Atembeschwerden, Wucherungen in der Nase, Schwindel) auf Aspirin oder ein NSAR (zB Ibuprofen, Celecoxib)

Sie vor kurzem oder werden mit Bypass-Herzoperation

Sie haben schwere Nierenprobleme

Sie sind in den letzten 3 Monaten der Schwangerschaft.

Fragen Sie Ihren Arzt oder Ihre Arztin sofort, wenn dies auf Sie zutrifft.

Einige medizinische Bedingungen konnen mit Diclofenac interagieren. Informieren Sie Ihren Arzt oder Apotheker, wenn Sie irgendwelche medizinischen Bedingungen haben, vor allem, wenn einer der folgenden Punkte auf Sie zutrifft:

wenn Sie schwanger sind, planen, schwanger zu werden, oder stillen

wenn Sie verschreibungspflichtige oder nicht verschreibungspflichtige Arzneimittel, pflanzliche Zubereitung oder Nahrungserganzungsmittel

wenn Sie Allergien gegen Medikamente, Nahrungsmittel oder andere Substanzen,

wenn Sie eine Geschichte der Nieren-oder Leberprobleme, Diabetes oder Magen-Darm-Probleme (zB Blutungen, Perforationen, Ulzera)

wenn Sie eine Geschichte von Schwellungen oder Flussigkeitsansammlungen, Asthma, Wucherungen in der Nase (Nasenpolypen) oder Entzundung der Mundschleimhaut

Wenn Sie hohen Blutdruck haben, Blutkrankheiten (z. B. Porphyrie), Blutungen oder Blutgerinnung Probleme, Herzbeschwerden (zB Herzinsuffizienz) oder Blutgefa?-Krankheit, oder wenn Sie mit einem Risiko fur eine dieser Krankheiten

wenn Sie schlechte Gesundheit, Dehydrierung oder niedrigen Flussigkeitsvolumen oder niedrige Blut-Natrium Ebenen, Sie rauchen, Alkohol trinken oder haben eine Geschichte des Alkoholmissbrauchs

wenn Sie nehmen ein Antibiotikum oder ein Anti-Anfall Medikamente. Das Risiko von Leberproblemen kann mit einigen dieser Medikamente erhoht werden.

Einige Arzneimittel konnen mit Diclofenac interagieren. Informieren Sie Ihren Arzt, wenn Sie andere Arzneimittel einnehmen, vor allem einer der folgenden Eigenschaften sind:

Antikoagulantien (zB Warfarin), Aspirin, Clopidogrel, Kortikosteroide (zB Prednison), Heparin und andere Blutverdunner (zB Dalteparin), oder selektive Serotonin-Wiederaufnahmehemmer (SSRI) (zB Fluoxetin), weil das Risiko von Magenblutungen kann gestiegen

Acetaminophen, weil das Risiko von Leberproblemen kann erhoht werden

Probenecid, weil es das Risiko von Diclofenac die Nebenwirkungen erhohen

Cyclosporin, Lithium, Metformin, Methotrexat, orale NSAR (zB Ibuprofen) oder Chinolone (zB Ciprofloxacin), weil das Risiko der Nebenwirkungen konnen durch Diclofenac erhoht werden

Angiotensin-Converting-Enzym (ACE)-Hemmer (zB Enalapril) oder Diuretika (zB Furosemid, Hydrochlorothiazid), weil ihre Wirksamkeit durch Diclofenac verringert werden kann.

Dies kann nicht eine vollstandige Liste aller Interaktionen, die auftreten konnen. Fragen Sie Ihren Arzt, wenn Diclofenac mit anderen Medikamenten, die Sie einnehmen. Prufen Sie mit Ihrem Arzt, bevor Sie starten, stoppen, oder andern Sie die Dosis einer Medizin.

Wichtige Sicherheitshinweise:

Diclofenac kann Schwindel oder Benommenheit. Diese Auswirkungen konnen noch schlimmer, wenn Sie es mit Alkohol oder bestimmte Medikamente. Verwenden Sie Diclofenac mit Vorsicht. Nicht Auto fahren oder andere moglicherweise unsichere Aufgaben, bis Sie, wie Sie darauf reagieren.

Serious Magengeschwur oder Blutungen konnen mit dem Einsatz von Diclofenac auftreten. Taking it in hohen Dosen fur eine lange Zeit, Rauchen oder Alkoholkonsum erhoht das Risiko fur diese Nebenwirkungen. Unter Diclofenac mit Lebensmitteln nicht zur Verringerung des Risikos dieser Effekte. Schwarzer, zaher Stuhl;; Erbrochenes, das wie Blut oder Kaffeesatz aussieht, wenn Sie an einer schweren Magen-oder Ruckenschmerzen haben oder ungewohnliche Gewichtszunahme oder Schwellungen, wenden Sie sich an Ihren Arzt oder Notaufnahme sofort.

Nehmen Sie nicht mehr als die empfohlene Dosis oder Verwendung langer als ohne Rucksprache mit Ihrem Arzt verordnet.

Diclofenac ist ein NSAR. Bevor Sie eine neue Medizin zu starten, uberprufen Sie das Etikett zu sehen, ob es ein NSAR (zB Ibuprofen) hat es auch. Ist dies der Fall, oder wenn Sie nicht sicher sind, mit Ihrem Arzt oder Apotheker.

Nehmen Sie kein Aspirin, wenn Sie mit Diclofenac werden, wenn Ihr Arzt Ihnen sagt.

Erkundigen Sie sich bei Ihrem Arzt oder Apotheker, bevor Sie Paracetamol nehmen, wahrend Sie unter Diclofenac. Das Risiko von Lebererkrankungen kann erhoht werden.

Nicht zwischen verschiedenen Formen von Diclofenac (zB magensaftresistente Tabletten, mit sofortiger Freisetzung Tabletten, Kapseln) zu wechseln, wenn Ihr Arzt Ihnen sagt. Sie durfen nicht die gleiche Menge der Medizin, um Ihren Korper.

Labortests, einschlie?lich der Nierenfunktion, Leberfunktion, Blut Elektrolyt-Niveau, Blutbild, Blutdruck, kann durchgefuhrt werden, wahrend Sie Diclofenac verwenden. Diese Tests konnen verwendet werden, um Ihren Zustand zu uberprufen oder auf Nebenwirkungen zu uberwachen. Achten Sie darauf, alle Arzt-und Labor-Terminen.

Verwenden Sie Diclofenac mit Vorsicht bei alteren Menschen, sie kann mehr empfindlich auf die Auswirkungen, insbesondere Magenblutungen und Nierenprobleme.

Diclofenac sollte mit au?erster Vorsicht bei Kindern angewendet werden, Sicherheit und Wirksamkeit bei Kindern wurden nicht bestatigt.

Schwangerschaft und Stillzeit: Diclofenac kann zu Schadigungen des Fotus. Verwenden Sie es nicht in den letzten 3 Monaten der Schwangerschaft. Wenn Sie glauben, schwanger zu sein, wenden Sie sich an Ihren Arzt. Sie mussen die Vorteile und Risiken der Verwendung von Diclofenac zu diskutieren, wahrend Sie schwanger sind. Es ist nicht bekannt, ob Diclofenac in der Muttermilch gefunden wird. Nicht stillen wahrend der Einnahme von Diclofenac.

Alle Arzneimittel konnen Nebenwirkungen haben, die aber viele Menschen haben keine oder nur geringfugige, Nebenwirkungen.

Erkundigen Sie sich bei Ihrem Arzt, wenn dieser am haufigsten auftretenden Nebenwirkungen fortbestehen oder storend empfunden werden:

Verstopfung, Durchfall, Schwindel, Benommenheit, Kopfschmerzen, leichte Bauchschmerzen oder Sodbrennen, Ubelkeit, Erbrechen.

Arztlich behandeln lassen, sofort, wenn dieser schwere Nebenwirkungen auftreten:

Schwere allergische Reaktionen (Hautausschlag, Nesselsucht, Juckreiz, Atembeschwerden, Engegefuhl in der Brust, Schwellungen im Mund-, Gesichts-, Lippen oder Zunge), blutig oder schwarz, Teerstuhle; Veranderung in Hohe von Urin produziert; Schmerzen in der Brust, Verwirrung. Depressionen, Ohnmacht, schneller oder unregelma?iger Herzschlag, Fieber, Schuttelfrost, oder anhaltende Halsschmerzen, psychische oder Stimmungsschwankungen, Taubheitsgefuhl in einem Arm oder Bein, einseitige Schwache, anhaltende Grippe-ahnliche Symptome, rot, geschwollen, Blasen, oder Schalen Haut, Klingeln in den Ohren, Krampfanfalle, schwere Kopfschmerzen oder Schwindel, schweren oder anhaltenden Bauchschmerzen oder Ubelkeit, starkem Erbrechen oder Durchfall, Atemnot, plotzlicher oder unerklarliche Gewichtszunahme, Schwellungen der Hande, Beine oder Fu?e; Symptome von Leber Probleme (zB, dunkler Urin, heller Stuhl, anhaltender Appetitlosigkeit, Gelbfarbung der Haut oder Augen), ungewohnliche blaue Flecken oder Blutungen, ungewohnliche Gelenk-oder Muskelschmerzen, ungewohnliche Mudigkeit oder Schwache; Vision oder Anderungen Rede, Erbrochenes, das wie Kaffeesatz aussieht .

Dies ist keine vollstandige Liste aller Nebenwirkungen, die auftreten konnen. Wenn Sie Fragen zu Nebenwirkungen haben, wenden Sie sich an Ihren Arzt.



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Zolmia, Zolmia

Zolpidem

Chemical Name

Foreign Names

Zolpidemum (Latin)

Zolpidem (German)

Zolpidem (French)

Zolpidem (Spanish)

Generic Names

Zolpidem (OS: BAN, DCF, DCIT)

SL 800750 (IS)

UNII-7K383OQI23 (IS)

Zolpidem Tartrate (OS: BANM, USAN, JAN)

HSDB 7045 (IS)

SL 800750-23N (IS)

UNII-WY6W63843K (IS)

Zolpidem hemitartrate (IS)

Zolpidem hydrogenotartras (IS)

Zolpidem (tartrat de) (PH: Ph. Eur. 8)

Zolpidem Tartrate (PH: BP 2016, JP XVI, USP 38)

Zolpidem tartrate (PH: Ph. Eur. 8)

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NORMATENS - 940678

TRADEMARK DETAILS Owner:

BGP Products B. V.

Type:

Word

Description:

NORMATENS

NORMATENS with trademark number 940678 was lodged on 20/01/2003 and has a status of Registered/Protected. The applicant/owner of the trademark is registered as BGP Products B. V. They used the trademark attorney firm Corrs Chambers Westgarth to file this trademark.

Australian trademark 940678 is one of over a million that we feature on IP in Australia which covers the entire spectrum of trademarks in Australia. BGP Products B. V. is also one of thousands of applicants we’ve analysed. We also understand who are the most prolific inventors in Australia with details on all the trademarks attributed to individuals.

Because we have insights into all the attorney firms that have been used across Australia including which specific trademark attorney worked on each trademark, we have access to unique analytics on the best attorney to use if you have specific trademark needs.

Filing trademarks is a time consuming and expensive exercise which is why care needs to be taken ensuring that you’re working with the right individual.

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Buy Clorampast - Chloramphenicol - Online Without Prescriptions, Clorampast

Chloramphenicol (Clorampast)

Chloramphenicol is used for treating serious infections caused by certain bacteria. Chloramphenicol is an antibiotic. It works by killing or slowing the growth of sensitive bacteria.

Use Chloramphenicol as directed by your doctor.

Take Chloramphenicol by mouth with or without food.

If you miss a dose of Chloramphenicol, use it as soon as possible. Then use your doses at evenly spaced times as directed by your doctor. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Chloramphenicol.

Store Chloramphenicol at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Keep Chloramphenicol out of the reach of children and away from pets.

Do NOT use Chloramphenicol if:

you are allergic to any ingredient in Chloramphenicol

you have previously had serious side effects from Chloramphenicol

you have a low white or red blood cell count or decreased blood platelets

you have a minor infection such as a cold, flu, throat infection, or you are using Chloramphenicol to prevent a bacterial infection

you are taking other medicines that may decrease your bone marrow (eg, cancer chemotherapy); check with your doctor or pharmacist if you are unsure if any of your other medicines may decrease your bone marrow.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Chloramphenicol. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have anemia, bone marrow problems, liver disease, or kidney problems.

Some medicines may interact with Chloramphenicol. Tell your health care provider if you are taking any other medicines, especially any of the following:

Anticoagulants (eg, warfarin) because side effects, including risk of bleeding, may be increased

Hydantoins (eg, phenytoin) or sulfonylureas (eg, glyburide) because the actions and side effects of these medicines may be increased.

Medicines that may decrease your bone marrow (eg, cancer chemotherapy ) because the risk of serious side effects, such as low blood platelet levels and low white blood cell counts, may be increased; check with your doctor or pharmacist if you are unsure if any of your medicines may decrease your bone marrow.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Chloramphenicol may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Do not exceed the recommended dose or use Chloramphenicol for longer than prescribed without checking with your doctor.

Chloramphenicol is effective only against bacteria. It is not effective for treating viral infections (eg, the common cold).

It is important to use Chloramphenicol for the full course of treatment. Failure to do so may decrease the effectiveness of Chloramphenicol and increase the risk that the bacteria will no longer be sensitive to Chloramphenicol and will not be able to be treated by this or certain other antibiotics in the future.

Long-term or repeated use of Chloramphenicol may cause a second infection. Your doctor may want to change your medicine to treat the second infection. Contact your doctor if signs of a second infection occur.

If symptoms of "gray syndrome" (swelling of the abdomen, pale or blue skin color, vomiting, shock, difficulty breathing, refusal to suck, loose green stools, limp muscles, low temperature) occur in a newborn or infant, contact your doctor. Death may occur within hours of the onset of symptoms. Stopping use of Chloramphenicol when symptoms first appear increases the chance for a complete recovery.

Chloramphenicol may lower your body's ability to fight infection. Prevent infection by avoiding contact with people with colds or other infections. Notify your doctor of any signs of infection, including fever, sore throat, rash, or chills.

Chloramphenicol may reduce the number of clot-forming cells (platelets) in your blood. To prevent bleeding, avoid situations in which bruising or injury may occur. Report any unusual bleeding, bruising, blood in stools, or dark, tarry stools to your doctor.

Diabetes patients - Chloramphenicol may affect your blood sugar. Check blood sugar levels closely and ask your doctor before adjusting the dose of your diabetes medicine.

LAB TESTS, including complete blood cell counts, may be performed to monitor your progress or check for side effects. Be sure to keep all doctor and lab appointments.

Use Chloramphenicol with extreme caution in children younger 1 year. Safety and effectiveness in this age group have not been confirmed.

Use Chloramphenicol with extreme caution in children younger 10 years who have diarrhea or a stomach or bowel infection.

Use Chloramphenicol with extreme caution in premature and full-term infants because they may be more sensitive to the effects of Chloramphenicol, especially the risk of "gray syndrome."

Pregnancy and breast-feeding: If you become pregnant while taking Chloramphenicol, discuss with your doctor the benefits and risks of using Chloramphenicol during pregnancy. Chloramphenicol should be used with extreme caution during full-term pregnancy and labor because the fetus may experience severe side effects. Chloramphenicol is excreted in breast milk. Do not breastfeed while taking Chloramphenicol.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Mild diarrhea, nausea, or vomiting.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; dark urine; delirium; depression; headache; fever, chills, or sore throat; pain, redness, or swelling at the injection site; symptoms of "gray syndrome" in an infant (swelling of the abdomen, pale or blue skin color, vomiting, shock, difficulty breathing, refusal to suck, loose green stools, limp muscles, low temperature); unusual bleeding or bruising; unusual tiredness; vision changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Delos - Delos Island, Greece, Delos

Delos, Delos Island

As the birthplace of Artemis and Apollo, the Greek island of Delos (Greek: Δηλος; Dhílos, "Brilliant") was a major sacred site for the ancient Greeks, second in importance only to Delphi. At its height, the sacred island was covered in a variety of temples and sanctuaries dedicated to a variety of gods. Today, it is a fascinating archaeological site located just two miles from Mykonos .

History of Delos

Remains of a settlement found on top of Mt. Kinthos show that Delos was inhabited since the 3rd millenium BC . Originally known as Ortygia (Quail Island), it was a religious center and busy port from ancient times. Although a barren island with virtually no natural resources, its harbors are protected by the three islands that circle around it (the Cyclades) and it is conveniently located between the Greek mainland and the Asian coast.

According to Greek mythology, Delos was the birthplace of Artemis and Apollo . the twin offspring of Zeus by Leto. When Leto was discovered to be pregnant, Zeus' jealous wife Hera banished her from the earth, but Poseidon took pity on her and provided Delos as a place for her to give birth in peace.

The Ionians colonized Delos around 1000 BC and made it their religious capital. The island was so sacred that, at one point, no one was allowed to be born or to die there - those about to do either were rushed off to the nearby islet of Rinia. A great festival, the Delia . was hosted here in honor of Apollo, Artemis and Leto, as described in Homeric Hymn 3 .

By the 7th century, Delos was also the political capital of the Amphictionic League. The Athenians soon joined the league and assumed control, giving the Delians trouble on a regular basis until around 315 BC, when the Egyptians became the rulers of the Aegean Sea.

Delos was most prosperous in Late Hellenistic and Roman times, when it was declared a free port and became the financial and trading center of the Mediterranean. By 100 BC the island had a population of 30,000, which included foreigners from as far away as Rome, Syria, and Egypt. Each group built its own shrines and lived in relative harmony despite their differences. By Roman times, the island's commercial role exceeded its previous religious importance.

But in 88 BC Mithridates, the king of Pontus, attack on the unfortified island as part of a revolt against Roman rule. The entire population of 20,000 was killed or sold into slavery, the sanctuary treasures were looted, and the city was razed to the ground. The Romans partially rebuilt the city, but revival was prevented by continous pirate raids.

A Roman legate built defensive walls around the city in 66 BC, but by then Delos was on its way out. It was gradually abandoned in the centuries that followed. In the 2nd century AD, Pausanius recorded that it was inhabited only by the temple guards.

Delos was never forgotten, however, which meant further destruction and looting by the successive rulers of the area - pirates, Knights of St. John, Venetians, Turks - as well as its neighbors Mykonos and Tinos. In the 17th century, Sir Kenelm Digby removed some marbles from Delos for the collection of Charles I.

Formal excavation work began in 1872 by the French School of Archaeology, which still continues today. The island is still uninhabited except for the French archaeologists and site guardians.

What to See at Delos

Boats from Mykonos arrive on the west coast of Delos Island, in the Commercial Harbor near the south end of the ruins. The island is small, only 1.2km wide and covering 5 sq km of barren, hilly landscape.

The ruins of ancient Delos extend north and south along the coast and consist of four main areas: the Maritime Quarter (next to the harbor); Theater District (southeast of the harbor); Sanctuary of Apollo (north of the harbor in the center of the site); and Lion District (north end of the ruins). A small tourist center in the Sanctuary of Apollo includes a pricey restaurant and bar, but no overnight accommodations. Informational signs among the ruins are in Greek and French.

The first major monument visitors encounter is the Agora of the Competialists (c.150 BC), an open area occupying the area between the Sacred Harbor and the Commercial Harbor. In the center of the ruins is a round shrine and a square base, where offerings were placed.

The Competialists were Roman merchants and freemen who conducted annual festivals in honor of the Lares Compitales . Roman gods of the crossroads associated with Hermes. These were minor gods, but as patrons of travelers and commerce, very important to the island's inhabitants. The nearby Ionic Naiskos . with a marble offertory box decorated with two snakes, also dates from about 150 BC and was probably built by the Competialists.

From the left side of the Agora, the Sacred Way (or Dromos) leads to the Sanctuary of Apollo. A paved road 45 feet wide, the Sacred Way is lined with marble bases that once supported statues and monuments donated by kings and generals. This was the route traveled by ancient pilgrims and the annual procession during the Delia festival.

On the left (coastal) side of the Sacred Way is the Stoa of Philip . a gift to Apollo from Philip V of Macedon (c.200 BC), who was then ruler of the Cyclades. The dedicatory inscription on the architrave has survived. The stoa had 16 Doric columns of grey marble, of which only one still stands. On the right side of the road is the South Stoa . built in the 3rd century BC.

The Sanctuary of Apollo was the ancient heart of Delos and is the most important area for today's visitors as well. It once contained three great temples dedicated to Apollo along with many other temples, altars and monuments. Also nearby are the Sacred Lake, Sanctuary of Dionysus, site museum and tourist pavilion.

Entrance to the sanctuary from the Sacred Way was marked by the Propylaea (c.150 BC) three portals made of white marble and supported by four Doric columns.

Sadly, little remains of the great temples today. The first of them is the Great Temple of Apollo . begun around 477 BC, neglected after the treasury was transferred to Athens in 454 BC, and finally completed in the 200s BC. It was a Doric peripteral structure with six rows of 13 columns measuring 29.6m by 13.4m. The metopes were left plain and the architrave was decorated only with palm leaves and lion spouts.

Next door is the Temple of the Athenians (425-17 BC), a Doric amphiprostyle building with six columns on the facade and a total area of 17.8m by 11.4m. In the cella, seven statues made of chryselephantine stood on a semicircular pedestal of Eleusinian marble. The temple was probably home to the Archaic statue of Apollo (see below).

The third great temple in the sanctuary is the Porinos Naos (6th century), measuring 15.7m by 10m, where the treasure of the Delian League was originally kept.

On the right side of the sanctuary is the ancient House of the Naxians (7th-6th century BC), a shrine where the sanctuary treasures were stored.

Against the north wall is the base of a colossal Statue of Apollo (7th century BC) made of Naxian marble, which Plutarch said was destroyed when a bronze palm tree blew over onto it in 417 BC. It was probably re-erected in its present position. A piece of the foot is in the British Museum, a hand is in the Delos site museum, and part of the trunk and the thighs are behind the Temple of Artemis on Delos.

The statue base bears several inscriptions: the original dedication in Archaic letters, which reads "I am of the same marble, statue and pedestal"; a 4th-century dedication reading "The Naxians to Apollo"; and later graffiti from Venetians and 17th-century travelers.

The granite base of the bronze palm tree . with a cylindrical hole in the center, can be seen on the west side of the Sacred Way. Part of the dedicatory inscription survives, naming Nikias as the donor.

Inland of the sanctuary is the tourist pavilion and site museum . which displays a variety of artifacts found during excavations. Admission is included in the site ticket. Next to the museum is the Sanctuary of Dionysus . best-known for its monumental phalluses.

On the north end of sanctuary was the Ionic Temple of Artemis (rebuilt c.179 BC), on a site that had been sacred since Mycenaean times. Many statues of Artemis were found here and are displayed in the museum. Ionic porticoes on the east and north side provide borders to the sanctuary of Apollo's twin sister. On the left side of the site is a curious semicircular platform . which may be a cult object from c.1500-1400 BC.

The Lion District, occupying the north end of the ruins, is named for the famous Terrace of the Lions (7th century BC). Here at least nine elegant lions made of Naxian marble guarded the sanctuary, looking out to the Sacred Lake. This arrangement recalls the avenues of guardian animals in Egypt, such as at Karnak. The lions on the site are replicas; five weathered originals are displayed in the museum. Another one has been at the Arsenal in Venice since the 17th century.

The oval Sacred Lake . drained since 1926, is where the sacred swans and geese of Apollo were kept. A palm tree has been planted in the center in honor of the one Leto clutched while giving birth to her divine twins.

Beyond the Terrace of the Lions is the Institution of the Poseidoniasts of Berytos . an association of merchants from Beirut who worshipped Baal, identifying him with the Greek god Poseidon. The complex includes several courtyards, chapels, meeting rooms, and shops.

The Maritime Quarter was the main residential area of Delos when the city was at its peak of prosperity, and the ruins of many beautiful mansions and villas can be seen here (south of the site entrance). Many of them were paved with fine mosaics ; some of these are still in situ . The House of the Masks has a mosaic of Dionysus riding a panther, and the House of Dionysus has another depiction of the popular god.

Further south in the Theater Quarter is the great classical theater of Delos (which could seat 5500 people) and more houses with mosaic floors. Especially notable is the House of the Dolphins (just east of the theater), with a fine mosaic depicting the gentle sea creatures.

The southeast end of the ruins is occupied by the various sanctuaries of both Greek and foreign gods.

A path from the southeast corner of the Theater Quarter leads steeply up Mount Kinthos, a conical hill rising 113m (370ft) in the center of the island. On the way is a Grotto of Hercules covered with stone slabs and there are fine views of the ruins and surrounding islands from the top.

Quick Facts on Delos

Note: This information was accurate when first published and we do our best to keep it updated, but details such as opening hours and prices can change without notice. To avoid disappointment, please check with the site directly before making a special trip.

References

More Information

© Uli Baecker © Uli Baecker Dolphin mosaic. © Zoe52 © Wally Gobetz Stoa of Philip. © Uli Baecker A short distance north of the Sanctuary of the Bulls is an oval indentation in the earth where the Sacred Lake. © Wally Gobetz © Howard Chalkley Phallus and related reliefs at the Shrine of Dionysus. © Zoe52 © Wally Gobetz Statues in the House of Cleopatra. © Xenica & Bliss Temple of Isis. © spinorbital © Zoe52 View of the Maritime Quarter and harbor of Delos and surrounding islands. © Charles Haynes

Map of Delos, Delos Island

Below is a location map and aerial view of Delos. Using the buttons on the left (or the wheel on your mouse), you can zoom in for a closer look, or zoom out to get your bearings. To move around, click and drag the map with your mouse.

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Except where indicated otherwise, all content and images © 2005-2016 Sacred Destinations. All rights reserved.



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Diethylpropion

70025263 Diethylpropion HCl USP C-IV Immediate-Release 25 mg Tablets Diethylpropion HCl USP C-IV Controlled-Release 75 mg Tablets Rx only Rev. March 2014

Diethylpropion Description

Diethylpropion hydrochloride is available for oral administration in immediate-release tablets containing 25 mg Diethylpropion hydrochloride and in controlled-release tablets containing 75 mg Diethylpropion hydrochloride. The inactive ingredients in each immediate-release tablet are: cornstarch, lactose, magnesium stearate, pregelatinized cornstarch, talc, and tartaric acid. The inactive ingredients in each controlled-release tablet are: carbomer 934P, mannitol, povidone, tartaric acid, zinc stearate. Diethylpropion hydrochloride is a sympathomimetic agent. The chemical name for Diethylpropion hydrochloride is 1-phenyl-2-diethylamino-1-propanone hydrochloride.

Its chemical structure is:

The Diethylpropion hydrochloride 75 mg formulation is dispersed in a hydrophilic matrix. On exposure to water, the Diethylpropion hydrochloride is released at a relatively uniform rate as a result of slow hydration of the matrix. The result is controlled release of the anorectic agent.

Diethylpropion - Clinical Pharmacology

Diethylpropion hydrochloride is a sympathomimetic amine with some pharmacologic activity similar to that of the prototype drugs of this class used in obesity, the amphetamines. Actions include some central nervous system stimulation and elevation of blood pressure. Tolerance has been demonstrated with all drugs of this class in which these phenomena have been looked for.

Drugs of this class used in obesity are commonly known as "anorectics" or "anorexigenics." It has not been established, however, that the action of such drugs in treating obesity is primarily one of appetite suppression. For example, other central nervous system actions or metabolic effects may be involved. Adult obese subjects instructed in dietary management and treated with "anorectic" drugs lose more weight on the average than those treated with placebo and diet, as determined in relatively short-term clinical trials. The magnitude of increased weight loss of drug-treated patients over placebo-treated patients averages some fraction of a pound a week. However, individual weight loss may vary substantially from patient to patient. The rate of weight loss is greatest in the first weeks of therapy for both drug and placebo subjects and tends to decrease in succeeding weeks. The possible origins of the increased weight loss due to the various drug effects are not established. The amount of weight loss associated with the use of an "anorectic" drug varies from trial to trial, and the increased weight loss appears to be related in part to variables other than the drug prescribed, such as the physician/investigator relationship, the population treated, and the diet prescribed. Studies do not permit conclusions as to the relative importance of the drug and non-drug factors on weight loss.

The natural history of obesity is measured in years, whereas most studies cited are restricted to a few weeks duration; thus, the total impact of drug-induced weight loss over that of diet alone is unknown. Diethylpropion is rapidly absorbed from the GI tract after oral administration and is extensively metabolized through a complex pathway of biotransformation involving N-dealkylation and reduction. Many of these metabolites are biologically active and may participate in the therapeutic action of Diethylpropion hydrochloride. Due to the varying lipid solubilities of these metabolites, their circulating levels are affected by urinary pH. Diethylpropion and/or its active metabolites are believed to cross the blood-brain barrier and the placenta.

Diethylpropion and its metabolites are excreted mainly by the kidney. It has been reported that between 75-106% of the dose is recovered in the urine within 48 hours after dosing. Using a phosphorescence assay that is specific for basic compounds containing a benzoyl group, the plasma half-life of the aminoketone metabolites is estimated to be between 4 to 6 hours.

The controlled-release characteristics of the Diethylpropion hydrochloride 75 mg formulation have been demonstrated by studies in humans in which plasma levels of Diethylpropion-related materials were measured by phosphorescence analysis. Plasma levels obtained with the 75 mg Diethylpropion hydrochloride formulation administered once daily indicated a more gradual release than an immediate-release formulation (three 25 mg tablets given in a single dose).

The Diethylpropion hydrochloride 75 mg controlled-release formulation has not been shown superior in effectiveness to the same dosage of the immediate-release formulation (one 25 mg tablet three times daily). After administration of a single dose of the Diethylpropion hydrochloride 75 mg formulation (one 75 mg controlled-release tablet) or Diethylpropion hydrochloride solution (75 mg dose) in a crossover study using normal human subjects, the amount of parent compound and its active metabolites recovered in the urine within 48 hours for the two dosage forms were not statistically different.

Indications and Usage for Diethylpropion

Diethylpropion hydrochloride is indicated in the management of exogenous obesity as a short-term adjunct (a few weeks) in a regimen of weight reduction based on caloric restriction in patients with an initial body mass index (BMI) of 30 kg/m 2 or higher and who have not responded to appropriate weight reducing regimen (diet and/or exercise) alone. Below is a chart of BMI based on various heights and weights. BMI is calculated by taking the patient’s weight, in kilograms (kg), divided by the patient’s height, in meters (m), squared. Metric conversions are as follows: pounds divided by 2.2 = kg; inches x 0.0254 = meters.

Body Mass Index (BMI), kg/m 2

The usefulness of agents of this class (see CLINICAL PHARMACOLOGY ) should be measured against possible risk factors inherent in their use such as those described below. Diethylpropion hydrochloride is indicated for use as monotherapy only.

Contraindications

Pulmonary hypertension, advanced arteriosclerosis, hyperthyroidism, known hypersensitivity or idiosyncrasy to the sympathomimetic amines, glaucoma, severe hypertension. (See PRECAUTIONS .)

Patients with a history of drug abuse.

Use in combination with other anorectic agents is contraindicated.

During or within 14 days following the administration of monoamine oxidase inhibitors, hypertensive crises may result.

Warnings

Diethylpropion hydrochloride should not be used in combination with other anorectic agents, including prescribed drugs, over-the-counter preparations, and herbal products.

In a case-control epidemiological study, the use of anorectic agents, including Diethylpropion, was associated with an increased risk of developing pulmonary hypertension, a rare, but often fatal disorder. The use of anorectic agents for longer than 3 months was associated with a 23-fold increase in the risk of developing pulmonary hypertension. Increased risk of pulmonary hypertension with repeated courses of therapy cannot be excluded.

The onset or aggravation of exertional dyspnea, or unexplained symptoms of angina pectoris, syncope, or lower extremity edema suggest the possibility of occurrence of pulmonary hypertension. Under these circumstances, Diethylpropion hydrochloride should be immediately discontinued, and the patient should be evaluated for the possible presence of pulmonary hypertension.

Valvular heart disease associated with the use of some anorectic agents such as fenfluramine and dexfenfluramine has been reported. Possible contributing factors include use for extended periods of time, higher than recommended dose, and/or use in combination with other anorectic drugs. Valvulopathy has been very rarely reported with Diethylpropion hydrochloride monotherapy, but the causal relationship remains uncertain. The potential risk of possible serious adverse effects such as valvular heart disease and pulmonary hypertension should be assessed carefully against the potential benefit of weight loss. Baseline cardiac evaluation should be considered to detect preexisting valvular heart diseases or pulmonary hypertension prior to initiation of Diethylpropion hydrochloride treatment. Diethylpropion hydrochloride is not recommended in patients with known heart murmur or valvular heart disease. Echocardiogram during and after treatment could be useful for detecting any valvular disorders which may occur.

To limit unwarranted exposure and risks, treatment with Diethylpropion hydrochloride should be continued only if the patient has satisfactory weight loss within the first 4 weeks of treatment (e. g. weight loss of at least 4 pounds, or as determined by the physician and patient).

Diethylpropion hydrochloride is not recommended for patients who used any anorectic agents within the prior year.

If tolerance develops, the recommended dose should not be exceeded in an attempt to increase the effect; rather, the drug should be discontinued. Diethylpropion hydrochloride may impair the ability of the patient to engage in potentially hazardous activities such as operating machinery or driving a motor vehicle; the patient should therefore be cautioned accordingly.

Prolonged use of Diethylpropion hydrochloride may induce dependence with withdrawal syndrome on cessation of therapy. Hallucinations have occurred rarely following high doses of the drug. Several cases of toxic psychosis have been reported following the excessive use of the drug and some have been reported in which the recommended dose appears not to have been exceeded. Psychosis abated after the drug was discontinued.

When central nervous system active agents are used, consideration must always be given to the possibility of adverse interactions with alcohol.

Precautions

General

Caution is to be exercised in prescribing Diethylpropion hydrochloride for patients with hypertension or with symptomatic cardiovascular disease, including arrhythmias. Diethylpropion hydrochloride should not be administered to patients with severe hypertension.

Reports suggest that Diethylpropion hydrochloride may increase convulsions in some epileptics. Therefore, epileptics receiving Diethylpropion hydrochloride should be carefully monitored. Titration of dose or discontinuance of Diethylpropion hydrochloride may be necessary.

The least amount feasible should be prescribed or dispensed at one time in order to minimize the possibility of overdosage.

Information for Patient

The patient should be cautioned about concomitant use of alcohol or other CNS-active drugs and Diethylpropion hydrochloride. (See WARNINGS .) The patient should be advised to observe caution when driving or engaging in any potentially hazardous activity.

Laboratory Tests

Drug Interactions

Because Diethylpropion hydrochloride is a monoamine, hypertension may result when this agent is used with monoamine oxidase (MAO) inhibitors (see CONTRAINDICATIONS ).

Efficacy of Diethylpropion with other anorectic agents has not been studied and the combined use may have the potential for serious cardiac problems; therefore, the concomitant use with other anorectic agents is contraindicated.

Antidiabetic drug requirements (i. e. insulin) may be altered. Concurrent use with general anesthetics may result in arrhythmias. The pressor effects of Diethylpropion and those of other drugs may be additive when the drugs are used concomitantly; conversely, Diethylpropion may interfere with antihypertensive drugs (i. e. guanethidine, α-methyldopa). Concurrent use of phenothiazines may antagonize the anorectic effect of Diethylpropion.

Carcinogenesis, Mutagenesis, and Impairment of Fertility

No long-term animal studies have been done to evaluate Diethylpropion hydrochloride for carcinogenicity. Mutagenicity studies have not been conducted. Animal reproduction studies have revealed no evidence of impairment of fertility (see Pregnancy ).

Pregnancy

Pregnancy Category B. Reproduction studies have been performed in rats at doses up to 1.6 times the human dose (based on mg/m 2 ) and have revealed no evidence of impaired fertility or harm to the fetus due to Diethylpropion hydrochloride. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.

Spontaneous reports of congenital malformations have been recorded in humans, but no causal relationship to Diethylpropion has been established.

Abuse with Diethylpropion hydrochloride during pregnancy may result in withdrawal symptoms in the human neonate.

Nursing Mothers

Since Diethylpropion hydrochloride and/or its metabolites have been shown to be excreted in human milk, caution should be exercised when Diethylpropion hydrochloride is administered to a nursing woman.

Geriatric Use

Clinical studies of Diethylpropion hydrochloride did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.

This drug is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function.

Pediatric Use

Since safety and effectiveness in pediatric patients below the age of 16 have not been established, Diethylpropion hydrochloride is not recommended for use in pediatric patients 16 years of age and under.

Adverse Reactions

Cardiovascular: Precordial pain, arrhythmia (including ventricular), ECG changes, tachycardia, elevation of blood pressure, palpitation and rare reports of pulmonary hypertension. Valvular heart disease associated with the use of some anorectic agents such as fenfluramine and dexfenfluramine, both independently and especially when used in combination, have been reported. Valvulopathy has been very rarely reported with Diethylpropion hydrochloride monotherapy, but the causal relationship remains uncertain.

Central Nervous System: In a few epileptics an increase in convulsive episodes has been reported; rarely psychotic episodes at recommended doses; dyskinesia, blurred vision, overstimulation, nervousness, restlessness, dizziness, jitteriness, insomnia, anxiety, euphoria, depression, dysphoria, tremor, mydriasis, drowsiness, malaise, headache, and cerebrovascular accident

Gastrointestinal: Vomiting, diarrhea, abdominal discomfort, dryness of the mouth, unpleasant taste, nausea, constipation, other gastrointestinal disturbances

Allergic: Urticaria, rash, ecchymosis, erythema

Endocrine: Impotence, changes in libido, gynecomastia, menstrual upset

Hematopoietic System: Bone marrow depression, agranulocytosis, leukopenia

Miscellaneous: A variety of miscellaneous adverse reactions has been reported by physicians. These include complaints such as dysuria, dyspnea, hair loss, muscle pain, increased sweating, and polyuria.

Drug Abuse and Dependence

Diethylpropion hydrochloride is a schedule IV controlled substance. Diethylpropion hydrochloride has some chemical and pharmacologic similarities to the amphetamines and other related stimulant drugs that have been extensively abused. There have been reports of subjects becoming psychologically dependent on Diethylpropion. The possibility of abuse should be kept in mind when evaluating the desirability of including a drug as part of a weight reduction program. Abuse of amphetamines and related drugs may be associated with varying degrees of psychologic dependence and social dysfunction which, in the case of certain drugs, may be severe. There are reports of patients who have increased the dosage to many times that recommended. Abrupt cessation following prolonged high dosage administration results in extreme fatigue and mental depression; changes are also noted on the sleep EEG. Manifestations of chronic intoxication with anorectic drugs include severe dermatoses, marked insomnia, irritability, hyperactivity, and personality changes. The most severe manifestation of chronic intoxication is psychosis, often clinically indistinguishable from schizophrenia.

Overdosage

Manifestations of acute overdosage include restlessness, tremor, hyperreflexia, rapid respiration, confusion, assaultiveness, hallucinations, panic states, and mydriasis.

Fatigue and depression usually follow the central stimulation.

Cardiovascular effects include tachycardia, arrhythmias, hypertension or hypotension and circulatory collapse. Gastrointestinal symptoms include nausea, vomiting, diarrhea, and abdominal cramps. Overdose of pharmacologically similar compounds has resulted in convulsions, coma and death.

The reported oral LD 50 for mice is 600 mg/kg, for rats is 250 mg/kg and for dogs is 225 mg/kg.

Management of acute Diethylpropion hydrochloride intoxication is largely symptomatic and includes lavage and sedation with a barbiturate. Experience with hemodialysis or peritoneal dialysis is inadequate to permit recommendation in this regard. Intravenous phentolamine (Regitine ® ) has been suggested on pharmacologic grounds for possible acute, severe hypertension, if this complicates Diethylpropion hydrochloride overdosage.

Diethylpropion Dosage and Administration

Diethylpropion hydrochloride immediate-release:

One immediate-release 25 mg tablet three times daily, one hour before meals, and in midevening if desired to overcome night hunger.

Diethylpropion hydrochloride controlled-release:

One controlled-release 75 mg tablet daily, swallowed whole, in midmorning.

This drug is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function. (See PRECAUTIONS, Geriatric Use .)

How is Diethylpropion Supplied

25 mg immediate-release tablets in bottles of 100.

Each white, round tablet is debossed Watson over 783 .

Keep tightly closed. Store at room temperature, below 30°C (86°F).

75 mg controlled-release tablets in bottles of 100.

Each white, capsule-shaped tablet is debossed Watson 782 .

Keep tightly closed. Store at room temperature, below 30°C (86°F).

Distributed By: Actavis Pharma, Inc. Parsippany, NJ 07054

Manufactured By: Patheon Pharmaceuticals Inc. Cincinnati, OH 45237 USA

Content Updated: March 2014

PRINCIPAL DISPLAY PANEL

Diethylpropion Hydrochloride Tablets USP CIV 25 mg NDC 0591-0783-01 Bottle label 100 tablets

PRINCIPAL DISPLAY PANEL

Diethylpropion Hydrochloride Controlled-release Tablets CIV 75 mg NDC 0591-0782-01 Bottle label 100 tablets

Diethylpropion HCL IMMEDIATE-RELEASE Diethylpropion hydrochloride tablet



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Cozaar (Loctenk)

Cozaar is used for treating high blood pressure alone or with other medicines. It is used in certain patients to decrease the risk of stroke. It is used in certain patients to treat kidney problems caused by diabetes (diabetic nephropathy). Cozaar is an angiotensin II receptor blocker (ARB). It works by relaxing blood vessels. This helps to lower blood pressure.

Use Cozaar as directed by your doctor.

Take Cozaar by mouth with or without food.

Take Cozaar on a regular schedule to get the most benefit from it. Taking Cozaar at the same time each day will help you remember to take it.

Continue to take Cozaar even if you feel well. Do not miss any dose.

If you miss a dose of Cozaar, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Cozaar.

Store Cozaar at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Cozaar out of the reach of children and away from pets.

Active Ingredient: Losartan potassium.

Do NOT use Cozaar if:

you are allergic to any ingredient in Cozaar

you are in your second or third trimester of pregnancy

the patient is a child with severe kidney problems.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Cozaar. Tell your health care provider if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you are able to become pregnant

if you have a history of angioedema (swelling of the hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; or hoarseness), including angioedema caused by treatment with an angiotensin-converting enzyme (ACE) inhibitor (eg, lisinopril)

if you have a history of heart problems (eg, heart failure), blood vessel problems, blood flow problems, liver or kidney problems, or diabetes

if you have a history of stroke or recent heart attack

if you are dehydrated or have low blood volume

if you have electrolyte problems (eg, high blood potassium levels, low blood sodium levels) or are on a low-salt (sodium) diet

if you are on dialysis or are scheduled to have major surgery.

Some medicines may interact with Cozaar. Tell your health care provider if you are taking any other medicines, especially any of the following:

Diuretics (eg, furosemide, hydrochlorothiazide) because the risk of low blood pressure may be increased

Potassium-sparing diuretics (eg, spironolactone, triamterene) or potassium supplements because the risk of high blood potassium levels may be increased

Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, indomethacin, celecoxib) or rifampin because they may decrease Cozaar's effectiveness

Lithium because the risk of its side effects may be increased by Cozaar.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Cozaar may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Cozaar may cause dizziness, lightheadedness, or fainting. These effects may be worse if you take it with alcohol or certain medicines. Use Cozaar with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Cozaar may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.

Cozaar may cause a serious side effect called angioedema. Contact your doctor at once if you develop swelling of the hands, face, lips, eyes throat, or tongue; difficulty swallowing or breathing; or hoarseness.

Cozaar may not work as well to reduce the risk of stroke in black patients. Discuss any questions or concerns with your doctor.

Dehydration, excessive sweating, vomiting, or diarrhea may increase the risk of low blood pressure. Contact your health care provider at once if any of these occur.

Check with your doctor before you use a salt substitute or a product that has potassium in it.

Tell your doctor or dentist that you take Cozaar before you receive any medical or dental care, emergency care, or surgery.

Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.

If you have high blood pressure, do not use nonprescription products that contain stimulants. These products may include diet pills or cold medicines. Contact your doctor if you have any questions or concerns.

Diabetes patients - This may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

Lab tests, including blood pressure, blood electrolyte levels, and heart, kidney, or liver function, may be performed while you use Cozaar. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Cozaar should not be used in children younger 6 years; safety and effectiveness in these children have not been confirmed.

Pregnancy and breast-feeding: Cozaar may cause birth defects or fetal death if you take it while you are pregnant. If you think you may be pregnant, contact your doctor right away. It is not known if Cozaar is found in breast milk. Do not breastfeed while taking Cozaar.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Diarrhea; dizziness; tiredness.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; hoarseness); change in the amount of urine produced; chest pain; dark urine; difficulty swallowing; fast, slow, or irregular heartbeat; muscle pain or cramps; severe or persistent stomach pain (with or without nausea or vomiting); symptoms of low blood pressure (eg, fainting, severe dizziness, lightheadedness); unusual bruising or bleeding; vision changes; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Cozaar (Loctenk)

Cozaar is used for treating high blood pressure alone or with other medicines. It is used in certain patients to decrease the risk of stroke. It is used in certain patients to treat kidney problems caused by diabetes (diabetic nephropathy). Cozaar is an angiotensin II receptor blocker (ARB). It works by relaxing blood vessels. This helps to lower blood pressure.

Use Cozaar as directed by your doctor.

Take Cozaar by mouth with or without food.

Take Cozaar on a regular schedule to get the most benefit from it. Taking Cozaar at the same time each day will help you remember to take it.

Continue to take Cozaar even if you feel well. Do not miss any dose.

If you miss a dose of Cozaar, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Cozaar.

Store Cozaar at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Cozaar out of the reach of children and away from pets.

Active Ingredient: Losartan potassium.

Do NOT use Cozaar if:

you are allergic to any ingredient in Cozaar

you are in your second or third trimester of pregnancy

the patient is a child with severe kidney problems.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Cozaar. Tell your health care provider if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you are able to become pregnant

if you have a history of angioedema (swelling of the hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; or hoarseness), including angioedema caused by treatment with an angiotensin-converting enzyme (ACE) inhibitor (eg, lisinopril)

if you have a history of heart problems (eg, heart failure), blood vessel problems, blood flow problems, liver or kidney problems, or diabetes

if you have a history of stroke or recent heart attack

if you are dehydrated or have low blood volume

if you have electrolyte problems (eg, high blood potassium levels, low blood sodium levels) or are on a low-salt (sodium) diet

if you are on dialysis or are scheduled to have major surgery.

Some medicines may interact with Cozaar. Tell your health care provider if you are taking any other medicines, especially any of the following:

Diuretics (eg, furosemide, hydrochlorothiazide) because the risk of low blood pressure may be increased

Potassium-sparing diuretics (eg, spironolactone, triamterene) or potassium supplements because the risk of high blood potassium levels may be increased

Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, indomethacin, celecoxib) or rifampin because they may decrease Cozaar's effectiveness

Lithium because the risk of its side effects may be increased by Cozaar.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Cozaar may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Cozaar may cause dizziness, lightheadedness, or fainting. These effects may be worse if you take it with alcohol or certain medicines. Use Cozaar with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Cozaar may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.

Cozaar may cause a serious side effect called angioedema. Contact your doctor at once if you develop swelling of the hands, face, lips, eyes throat, or tongue; difficulty swallowing or breathing; or hoarseness.

Cozaar may not work as well to reduce the risk of stroke in black patients. Discuss any questions or concerns with your doctor.

Dehydration, excessive sweating, vomiting, or diarrhea may increase the risk of low blood pressure. Contact your health care provider at once if any of these occur.

Check with your doctor before you use a salt substitute or a product that has potassium in it.

Tell your doctor or dentist that you take Cozaar before you receive any medical or dental care, emergency care, or surgery.

Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.

If you have high blood pressure, do not use nonprescription products that contain stimulants. These products may include diet pills or cold medicines. Contact your doctor if you have any questions or concerns.

Diabetes patients - This may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

Lab tests, including blood pressure, blood electrolyte levels, and heart, kidney, or liver function, may be performed while you use Cozaar. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Cozaar should not be used in children younger 6 years; safety and effectiveness in these children have not been confirmed.

Pregnancy and breast-feeding: Cozaar may cause birth defects or fetal death if you take it while you are pregnant. If you think you may be pregnant, contact your doctor right away. It is not known if Cozaar is found in breast milk. Do not breastfeed while taking Cozaar.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Diarrhea; dizziness; tiredness.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; hoarseness); change in the amount of urine produced; chest pain; dark urine; difficulty swallowing; fast, slow, or irregular heartbeat; muscle pain or cramps; severe or persistent stomach pain (with or without nausea or vomiting); symptoms of low blood pressure (eg, fainting, severe dizziness, lightheadedness); unusual bruising or bleeding; vision changes; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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Clarilind, Clarilind

Clarithromycin

Click for further information on drug naming conventions and International Nonproprietary Names .

Important Notice: The Drugs. com international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

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Product Description Common use Biaxin belongs to a group of macrolide antibiotics, which inhibit bacterial synthesis of protein. This action is mainly bacteriostatic, but can also be bactericidal. Macrolides tend to accumulate within leukocytes, and are transported into the site of infection. Biaxin is effective against Haemophilus influenzae, Streptococcus pneumoniae, Mycoplasma pneumoniae, Staphylococcus aureus, mycobacterium avium, and many others so it is used to treat many kinds of bacterial infections of skin and respiratory system, stomach ulcers caused by Helicobacter pylori.

Dosage and directions Biaxin tablets should be taken with or without food with a big glass of water. Swallow the pill whole. Do not take more of the medication than it was recommended to you. Continue to take the drug even if symptoms of your illness became less pronounced and you feel fine. Biaxin is usually given from 7 to 14 days or longer when stomach ulcers are treated.

Precautions Do not use this drug if you are allergic to erythromycin and any of its derivatives or related macrolide antibiotics. If you have diseases of liver or kidneys, mineral dis-balance (low levels of potassium or magnesium), certain heart disease, arrhythmias, discuss it with your doctor before taking Bizxin. This mediation is not recommended during pregnancy or breastfeeding.

Contraindications Biaxin cannot be administered in patients with a known hypersensitivity to clarithromycin, erythromycin, or any of the macrolide antibiotics.

Possible side effects If you have such signs of allergic reaction as hives, difficulty breathing, swelling of your face, lips, tongue, or throat or more serious signs of poor health as uneven heartbeats, chest pain, nausea, stomach pain, low fever, problems with hearing contact your doctor or pharmacist or seek for immediate medical help.

Biaxin may interact with cisapride, pimozide, ergot medicines and result in life-threatening heart rhythm disorders.

Never take a double dose of this medication. If it is almost time for the next dose just skip the missed portion and continue to take the medicine according to the schedule.

Signs of overdose may be: nausea, vomiting, diarrhea, and abdominal discomfort. If you suppose that you took too much of Biaxin contact your doctor for help.

Store at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture, kids and pets.

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information on the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care advisor or doctor in charge of the case. We disclaim all responsibility for the reliability of this information. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.



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Solodyn Oral Uses, Side Effects, Interactions, Pictures, Warnings - Dosing, Solodyn

Solodyn

Uses

This medication is used to treat moderate to severe acne in patients 12 years of age and older. It helps to reduce the number of pimples. Minocycline belongs to the class of antibiotics known as tetracyclines. It works by stopping the growth of bacteria that may worsen acne .

This antibiotic is approved to treat acne that is thought to be caused by a bacterial infection. It will not work for viral infections (e. g. common cold. flu ). Unnecessary use or overuse of any antibiotic can lead to its decreased effectiveness.

How to use Solodyn

Read the Patient Information Leaflet provided by your pharmacist before you start using this medication and each time you get a refill. If you have any questions, consult your doctor or pharmacist.

Take this medication by mouth with or without food, usually once daily or as directed by your doctor. Do not crush or chew extended-release tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split the tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.

Take each dose with a full glass of water (8 ounces or 240 milliliters) unless your doctor directs you otherwise. Do not lie down for 10 minutes after taking this medication. For this reason, do not take it right before bedtime. You may take this medication with food or milk to lower the chance of irritating the esophagus and stomach unless your doctor directs you otherwise.

Take this medication 2-3 hours before or after taking any medications containing magnesium. aluminum, or calcium. Some examples include antacids, quinapril. certain forms of didanosine (chewable/dispersible buffered tablets or pediatric oral solution), vitamins /minerals, and sucralfate. Follow the same instructions if you also take bismuth subsalicylate, iron, and zinc. They bind with minocycline preventing its full absorption.

Dosage is based on your medical condition, weight. and response to therapy.

Antibiotics work best when the amount of medicine in your body is kept at a constant level. Therefore, take this drug at evenly spaced intervals.

Continue to take this medication for the prescribed length of time. Do not skip doses. Stopping the medication too early or skipping doses may allow bacteria to continue to grow and increase the risk of developing resistant bacteria that are more difficult to treat.

Inform your doctor if your condition does not improve after 3 months of treatment or if it worsens.

Side Effects

Nausea. vomiting. diarrhea. lightheadedness, dizziness. unsteadiness, drowsiness, mild headache. mouth sores, or cough may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if any of these unlikely but serious side effects occur: sunburn (sun sensitivity), muscle pain. difficult/painful swallowing, signs of kidney problems (such as change in the amount of urine, pink urine), brown/gray tooth discoloration. blue/gray/brown discoloration of the skin /lips/tongue /gums, numbness/tingling of the hands/feet, unusual tiredness, stopping of menstrual periods, new signs of infection (e. g. fever, chills, persistent sore throat ).

Tell your doctor right away if any of these rare but very serious side effects occur: hearing changes (e. g. ringing in the ears. decreased hearing), easy bruising/bleeding.

Tetracycline drugs such as minocycline may rarely cause a serious increase in pressure inside the skull (intracranial hypertension - IH). The risk of this side effect is greater for women of childbearing age who are overweight or who have had IH in the past. If IH develops, it usually goes away after minocycline is stopped; however, there is a chance of permanent vision loss or blindness. Get medical help right away if you have: persistent/severe headache. vision changes (such as blurred/double vision. decreased vision. sudden blindness), persistent nausea/vomiting.

This medication may rarely cause a severe intestinal condition (Clostridium difficile - associated diarrhea) due to a type of resistant bacteria. This condition may occur during treatment or weeks to months after treatment has stopped. Do not use anti-diarrhea products or narcotic pain medications if you have any of the following symptoms because these products may make them worse. Tell your doctor right away if you develop: persistent diarrhea, abdominal or stomach pain /cramping, blood /mucus in your stool.

Use of this medication for prolonged or repeated periods may result in oral thrush or a new vaginal yeast infection (fungal infections). Contact your doctor if you notice white patches in your mouth. a change in vaginal discharge. or other new symptoms.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, skin lesions/sores, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing, new or worsening swelling/pain in the joints, swollen glands, loss of appetite/weight loss, chest pain, fast/irregular heartbeat, severe stomach/abdominal pain, yellowing eyes/skin, dark urine.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

See also Side Effects section.

Before taking minocycline, tell your doctor or pharmacist if you are allergic to it; or to tetracycline or related drugs (e. g. doxycycline); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, problems swallowing, esophagus problems (e. g. hiatal hernia, reflux disease-GERD), lupus.

This drug may make you dizzy or drowsy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

To minimize dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

This medication may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen and wear protective clothing when outdoors.

Before having surgery, tell your doctor or dentist that you are using minocycline.

Caution is advised when using this drug in the elderly because they may be more sensitive to its effects.

This medication should not be used in children younger than 8 years of age because it may cause permanent tooth discoloration and other problems. Tooth discoloration has also occurred in older children and young adults. Consult your doctor for more information.

This medication is not recommended for use during pregnancy because of possible harm to an unborn baby. Consult your doctor for more details. If you become pregnant or think you may be pregnant, tell your doctor right away.

This medication passes into breast milk in very small amounts. While there have been no reports of harm to nursing infants, consult your doctor before breast-feeding.

Interactions

See also How to Use section.

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

This drug should not be used with the following medications because very serious interactions may occur: retinoid medications taken by mouth (such as acitretin, isotretinoin).

If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting minocycline.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: digoxin, live bacterial vaccines, warfarin.

Although most antibiotics are unlikely to affect hormonal birth control such as pills, patch, or ring, a few antibiotics (such as rifampin, rifabutin) can decrease their effectiveness. This could result in pregnancy. If you use hormonal birth control, ask your doctor or pharmacist for more details.

This product can affect the results of certain lab tests. Make sure laboratory personnel and all your doctors know you use this drug.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

Overdose

If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Notes

Do not share this medication with others.

This medication has been prescribed for your current condition only. Do not use it later for another infection unless told to do so by your doctor. A different medication may be necessary in that case.

Laboratory and/or medical tests may be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up. Do not take more than one dose per day.

Storage

Store at room temperature at 77 degrees F (25 degrees C) away from light, moisture, and extreme heat. Brief storage between 59-86 degrees F (15-30 degrees C) is permitted. Do not store in the bathroom. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Taking outdated tetracycline-related drugs can result in serious illness. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Information last revised May 2016. Copyright(c) 2016 First Databank, Inc.

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Fucidin Cream, Fusidin Leo

FUCIDIN CREAM

Transcript

PACKAGE LEAFLET: INFORMATION FOR THE USER

FUCIDIN® CREAM (fusidic acid)

Read all of this leaflet carefully before you start using this medicine because it contains important information for you. ? ? ?

Keep this leaflet. You may need to read it again. If you have any further questions, ask your doctor, pharmacist or nurse. This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours. If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. See section 4.

What is in this leaflet

What Fucidin Cream is and what it is used for What you need to know before you use Fucidin Cream How to use Fucidin Cream Possible side effects How to store Fucidin Cream Contents of the pack and further information

1. What Fucidin Cream is and what it is used for

Warnings and precautions

Talk to your doctor, pharmacist or nurse before using Fucidin cream. ? Take special care if you are going to use this medicine near your eyes or the eyes of a child. ? If you use the cream over a long time or in large amounts it may make the chance of getting any side effects higher. Also your skin may get more sensitive to this medicine.

Other medicines and Fucidin Cream

Tell your doctor, pharmacist or nurse if you are taking, have recently taken or might take any other medicines.

Pregnancy and breast-feeding ?

Driving and using machines

Usually your medicine will have very little effect on your ability to drive or use machines. Check with your doctor if you feel any side effect that may stop you from driving or using machines.

Fucidin Cream contains ?

Fucidin Cream contains fusidic acid. It is a type of antibiotic. Fucidin Cream works by killing germs (bacteria) that cause infections. Fucidin Cream is used to treat conditions where the skin is infected by germs (bacteria), such as: ? Impetigo (a weeping, crusty and swollen patch of skin). ? Infected dermatitis (inflammation of the skin) and spots. ? Infected cuts and grazes.

2. What you need to know before you use Fucidin Cream Do not use Fucidin Cream ?

If you are allergic to fusidic acid or any of the other ingredients of this medicine (listed in section 6).

If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before using this medicine. Tell your doctor if you become pregnant while using this medicine. You must not use your medicine for a long time or in large amounts.

Butylated hydroxyanisole (E320). This may give you an itchy rash and inflammation on your skin where your medicine is used. This may also cause irritation to the eyes and mucous membranes (such as lips or genital area). Cetyl alcohol. This may give you an itchy rash and inflammation on your skin where your medicine is used. Potassium sorbate. This may give you an itchy rash and inflammation on your skin where your medicine is used.

Always wash your hands before using Fucidin Cream. Rub the medicine gently on the skin. If you use it on your face be careful to avoid your eyes. Unless you are using the cream to treat your hands, always wash your hands after using Fucidin Cream. If you accidentally get any medicine in your eye, wash it out with cold water straight away. Then bathe your eye with eyewash if possible. Your eye may sting. If you start to have any problems with your sight or your eye is sore, contact your doctor immediately.

How much Fucidin Cream to use

Your doctor will tell you how much Fucidin Cream to use. Usually, you should use this medicine three or four times each day. If you have been told to cover the skin with any dressings or bandages you may not need to use the medicine so often. A nappy on a baby may act as a dressing. Follow the advice of your doctor.

If you use more Fucidin Cream than you should

If you accidentally apply too much cream or a small quantity of the cream is accidentally swallowed, it is unlikely to cause any harm. If a larger quantity of the cream is accidentally swallowed or you are worried, contact your doctor, pharmacist or A&E department for advice.

If you forget to use Fucidin Cream

If you forget to use this medicine, use it as soon as you remember. Then next use this medicine at the usual time. If you have any further questions on the use of this medicine, ask your doctor, pharmacist or nurse.

4. Possible side effects

Please ask your doctor if you are worried about any of the ingredients in this medicine.

Like all medicines, this medicine can cause side effects, although not everybody gets them.

3. How to use Fucidin Cream

Important side effects to look out for:

Always use this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure.

Rare (may affect up to 1 in 1,000 people)

How to put on Fucidin Cream

This medicine is only for using on your skin or the skin of a child. Do not swallow it. Do not put it inside your body. Remove the cap. Check the seal is not broken before you first use the cream. Then push the spike in the cap through the seal on the tube.

You must get urgent medical help if you have any of the following symptoms.

You may be having an allergic reaction: ? ? ?

You have difficulty breathing Your face or throat swell Your skin develops a severe rash.

Other possible side effects: Uncommon side effects (may affect up to 1 in 100 people) ? ? ? ?

Irritation at site of application (including pain, burning, irritation, stinging and skin redness) Itching Rash Eczema.

You can find important information about some of the ingredients in your medicine near the end of section 2 of this leaflet.

What Fucidin Cream looks like and contents of the pack Fucidin Cream is a cream.

Fucidin Cream is supplied in tubes of 15g.

Rare side effects (may affect up to 1 in 1,000 people)

Reporting of side effects

Procured from within the EU and repackaged by: Doncaster Pharmaceuticals Group Ltd, Kirk Sandall, Doncaster, DN3 1QR.

Conjunctivitis Hives Skin swelling Blistering of the skin.

Your medicine is manufactured by: Leo Laboratories Limited, 285 Cashel Road, Dublin 12, Ireland.

If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www. mhra. gov. uk/yellowcard.

Product Licence holder: Landmark Pharma Ltd., 7 Regents Drive, Prudhoe, Northumberland, NE42 6PX.

By reporting side effects, you can help provide more information on the safety of this medicine.

Leaflet revision date: 18.12.15

PL No: 21828/0111

Fucidin® is a registered trademark of LEO Pharma A/S.

Do not use after the expiry date printed on the carton or tube. The expiry date is the last day of that month. There are no special storage instructions for Fucidin Cream. KEEP ALL MEDICINES OUT OF THE SIGHT AND REACH OF CHILDREN. If your doctor tells you to stop using this medicine, take any remaining medicine back to the pharmacist for safe disposal. Only keep the medicine if your doctor tells you to. If the cream becomes discoloured or shows signs of deterioration, you should seek the advice of your pharmacist. Medicines should not be thrown away in waste water or in household waste. Please ask your pharmacist how to throw away any medicine you do not need any more. If you do this you will help protect the environment.

6. Contents of the pack and further information What Fucidin Cream contains

Your medicine contains the active ingredient fusidic acid 2% W/W. Fucidin Cream also contains the following inactive ingredients: butylated hydroxyanisole, cetyl alcohol, glycerol, liquid paraffin, potassium sorbate, polysorbate 60, white soft paraffin, purified water.

Source: Medicines and Healthcare Products Regulatory Agency

Disclaimer: Every effort has been made to ensure that the information provided here is accurate, up-to-date and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This information has been compiled for use by healthcare practitioners and consumers in the United States. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective or appropriate for any given patient. If you have questions about the substances you are taking, check with your doctor, nurse or pharmacist.



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Blood Pressure

Lisinopril (Tivirlon)

Lisinopril is used for treating high blood pressure alone or with other medicines. It is used along with other medicines to manage heart failure or improve survival after a heart attack. Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor. It works by relaxing blood vessels. This helps to lower blood pressure.

Use Lisinopril as directed by your doctor.

Take Lisinopril by mouth with or without food.

If you miss a dose of Lisinopril, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Lisinopril.

Store Lisinopril at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Do not freeze. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Lisinopril out of the reach of children and away from pets.

Do NOT use Lisinopril if:

you are allergic to any ingredient in Lisinopril

you have a history of angioedema (swelling of the hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; or hoarseness), including angioedema caused by treatment with an ACE inhibitor

you are in your second or third trimester of pregnancy

the patient is a child with severe kidney problems.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Lisinopril. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you are able to become pregnant

if you have a history of heart problems (eg, heart failure, aortic stenosis), blood vessel problems, blood flow problems, bone marrow problems, kidney problems, or diabetes

if you have a history of stroke, recent heart attack, or kidney transplant

if you have an autoimmune disease (eg, rheumatoid arthritis, lupus, scleroderma)

if you are dehydrated or have low blood volume

if you have high blood potassium levels, low blood sodium levels, or are on a low salt (sodium) diet

if you are on dialysis or are scheduled to have major surgery.

Some medicines may interact with Lisinopril. Tell your health care provider if you are taking any other medicines, especially any of the following:

Diuretics (eg, furosemide, hydrochlorothiazide) because the risk of low blood pressure may be increased

Aldosterone blockers (eg, eplerenone), potassium-sparing diuretics (eg, spironolactone, triamterene), or potassium supplements because the risk of high blood potassium levels may be increased

Insulin, sulfonylureas (eg, glipizide), or other oral diabetes medicines (eg, metformin) because the risk of low blood sugar may be increased

Gold-containing medicines (eg, auranofin) because flushing, nausea, vomiting, and low blood pressure may occur

Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, indomethacin, celecoxib) or salicylates (eg, aspirin) because they may decrease Lisinopril's effectiveness

Lithium or thiopurines (eg, azathioprine) because the risk of their side effects may be increased by Lisinopril.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Lisinopril may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Lisinopril may cause dizziness, lightheadedness, or fainting. These effects may be worse if you take it with alcohol or certain medicines. Use Lisinopril with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Lisinopril may cause a serious side effect called angioedema. Contact your doctor at once if you develop swelling of the hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; or hoarseness.

Lisinopril may not work as well in black patients. They may also be at greater risk of side effects. Contact your doctor if your symptoms do not improve or if they become worse.

Dehydration, excessive sweating, vomiting, or diarrhea may increase the risk of low blood pressure. Contact your health care provider at once if any of these occur.

Rarely, Lisinopril may lower the ability of your body to fight infection. This risk may be greater if you have certain other health problems (eg, kidney problems, collagen vascular disease). Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.

Check with your doctor before you use a salt substitute or a product that has potassium in it.

Tell your doctor or dentist that you take Lisinopril before you receive any medical or dental care, emergency care, or surgery.

Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.

If you have high blood pressure, do not use nonprescription products that contain stimulants. These products may include diet pills or cold medicines. Contact your doctor if you have any questions or concerns.

Diabetes patients - Lisinopril may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

Lab tests, including blood pressure, blood electrolyte levels, heart function, or kidney or liver function, may be performed while you use Lisinopril. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Lisinopril with caution in the elderly; they may be more sensitive to its effects.

Lisinopril should not be used in children younger 6 years; safety and effectiveness in these children have not been confirmed.

Pregnancy and breast-feeding: Lisinopril may cause birth defects or fetal death if you take it while you are pregnant. If you think you may be pregnant, contact your doctor right away. It is not known if Lisinopril is found in breast milk. Do not breastfeed while taking Lisinopril.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Cough; diarrhea; dizziness; headache; tiredness.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the hands, eyes, mouth, face, lips, or tongue; hoarseness); chest pain; dark urine; decreased urination; difficulty swallowing; infection (eg, fever, chills, persistent sore throat); irregular or slow heartbeat; stomach pain (with or without nausea or vomiting); symptoms of low blood pressure (eg, fainting, severe dizziness, lightheadedness); yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Your order will be packed safely and secure and dispatched within 24 hours. This is how your parcel will look like, the images are photographs of real shipments. It has the size of a normal protected envelope and it does not disclose its contents.

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PROfertil®

PROfertil ® – unique, patented and clinically proven combination to support male fertility

Indications

Primary and secondary infertility

Accompanying/Preparation for IVF

What does PROfertil ® do?

Improvement of sperm quality and - quantity

Improvement of fertility in men with subclinical varicocele

Reduction of DNA fragmentation of sperm cells

PROfertil ® – the success can be measured

How to take PROfertil ® :

PROfertil ® is available as one-month supply (60 capsules) and as 3-month supply (180 capsules). It is recommended to take two capsules per day with some water, preferably with or after a meal. PROfertil ® should be taken for at least 3 months until a pregnancy occurs.

Mandatory Information/Particulars according Art. 9, Par. 1 Food Information Regulation (FIR) (EU 1169/2011 dated 25.10.2011) Download



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Unicycline, Unicycline

Sumycin is used for treating infections caused by certain bacteria. Sumycin is a tetracycline antibiotic. It works by slowing the growth of sensitive bacteria by interfering with the production of proteins needed by the bacteria to grow. Slowing the bacteria's growth allows the body's defense mechanisms to destroy them.

Use Sumycin as directed by your doctor.

Take Sumycin by mouth on an empty stomach at least 1 hour before or 2 hours after eating.

Take Sumycin with a full glass of water (8 oz/240 mL). Do not lie down for 30 minutes after taking Sumycin.

If you also take antacids containing aluminum, calcium, or magnesium; preparations containing bismuth, iron, zinc, or sodium bicarbonate; or calcium rich foods (eg, milk, dairy products, calcium-enriched juices), do not take them within 2 to 3 hours before or after taking Sumycin. Check with your doctor if you have questions.

To clear up your infection completely, take Sumycin for the full course of treatment. Keep taking it even if you feel better in a few days.

If you miss a dose of Sumycin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Sumycin.

Store Sumycin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C), in a tightly closed, light-resistant container. Keep away from heat, moisture, and light. Do not store in the bathroom. Keep Sumycin out of the reach of children and away from pets.

Active Ingredient: Tetracycline hydrochloride.

Do NOT use Sumycin if:

you are allergic to any ingredient in Sumycin or other tetracycline antibiotics (eg, doxycycline)

you are taking acitretin or methoxyflurane.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Sumycin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have diarrhea, a stomach infection, or kidney problems.

Some medicines may interact with Sumycin. Tell your health care provider if you are taking any other medicines, especially any of the following:

Acitretin or isotretinoin because side effects, such as increased pressure in the fluid surrounding the brain, may occur

Digoxin, methotrexate, methoxyflurane, or oral anticoagulants (eg, warfarin) because the risk of their side effects may be increased by Sumycin

Atovaquone, lithium, oral contraceptives (birth control pills), or penicillins (eg, amoxicillin) because their effectiveness may be decreased by Sumycin.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Sumycin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Sumycin may cause dizziness or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Sumycin with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.

Be sure to use Sumycin for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.

Sumycin may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Sumycin. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.

Do not use after expiration date. Outdated medicine is highly toxic to the kidneys.

Long-term or repeated use of Sumycin may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.

Hormonal birth control (eg, birth control pills) may not work as well while you are using Sumycin. To prevent pregnancy, use an extra form of birth control (eg, condoms).

Lab tests may be performed while you use Sumycin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use of Sumycin in children may cause permanent discoloring of the teeth.

Sumycin should be used with extreme caution in children younger 8 years; safety and effectiveness in these children have not been confirmed.

Pregnancy and beast-feeding: Sumycin has been shown to cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Sumycin while you are pregnant. Sumycin is found in breast milk. Do not breast-feed while taking Sumycin.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Black hairy tongue; blurred vision; bulky loose stools; diarrhea; difficulty swallowing; fever; headache; hives; hoarseness; indigestion; inflammation or redness of tongue; joint pain; loss of appetite; mouth sores; nausea; rash; sensitivity to sunlight; sore throat; stomach pain; swelling and itching of the rectum.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); infection (fever, chills, sore throat); itching; nausea; severe skin reaction to the sun; vaginal irritation or discharge; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Sumycin is used for treating infections caused by certain bacteria. Sumycin is a tetracycline antibiotic. It works by slowing the growth of sensitive bacteria by interfering with the production of proteins needed by the bacteria to grow. Slowing the bacteria's growth allows the body's defense mechanisms to destroy them.

Use Sumycin as directed by your doctor.

Take Sumycin by mouth on an empty stomach at least 1 hour before or 2 hours after eating.

Take Sumycin with a full glass of water (8 oz/240 mL). Do not lie down for 30 minutes after taking Sumycin.

If you also take antacids containing aluminum, calcium, or magnesium; preparations containing bismuth, iron, zinc, or sodium bicarbonate; or calcium rich foods (eg, milk, dairy products, calcium-enriched juices), do not take them within 2 to 3 hours before or after taking Sumycin. Check with your doctor if you have questions.

To clear up your infection completely, take Sumycin for the full course of treatment. Keep taking it even if you feel better in a few days.

If you miss a dose of Sumycin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Sumycin.

Store Sumycin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C), in a tightly closed, light-resistant container. Keep away from heat, moisture, and light. Do not store in the bathroom. Keep Sumycin out of the reach of children and away from pets.

Active Ingredient: Tetracycline hydrochloride.

Do NOT use Sumycin if:

you are allergic to any ingredient in Sumycin or other tetracycline antibiotics (eg, doxycycline)

you are taking acitretin or methoxyflurane.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Sumycin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have diarrhea, a stomach infection, or kidney problems.

Some medicines may interact with Sumycin. Tell your health care provider if you are taking any other medicines, especially any of the following:

Acitretin or isotretinoin because side effects, such as increased pressure in the fluid surrounding the brain, may occur

Digoxin, methotrexate, methoxyflurane, or oral anticoagulants (eg, warfarin) because the risk of their side effects may be increased by Sumycin

Atovaquone, lithium, oral contraceptives (birth control pills), or penicillins (eg, amoxicillin) because their effectiveness may be decreased by Sumycin.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Sumycin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Sumycin may cause dizziness or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Sumycin with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.

Be sure to use Sumycin for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.

Sumycin may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Sumycin. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.

Do not use after expiration date. Outdated medicine is highly toxic to the kidneys.

Long-term or repeated use of Sumycin may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.

Hormonal birth control (eg, birth control pills) may not work as well while you are using Sumycin. To prevent pregnancy, use an extra form of birth control (eg, condoms).

Lab tests may be performed while you use Sumycin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use of Sumycin in children may cause permanent discoloring of the teeth.

Sumycin should be used with extreme caution in children younger 8 years; safety and effectiveness in these children have not been confirmed.

Pregnancy and beast-feeding: Sumycin has been shown to cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Sumycin while you are pregnant. Sumycin is found in breast milk. Do not breast-feed while taking Sumycin.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Black hairy tongue; blurred vision; bulky loose stools; diarrhea; difficulty swallowing; fever; headache; hives; hoarseness; indigestion; inflammation or redness of tongue; joint pain; loss of appetite; mouth sores; nausea; rash; sensitivity to sunlight; sore throat; stomach pain; swelling and itching of the rectum.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); infection (fever, chills, sore throat); itching; nausea; severe skin reaction to the sun; vaginal irritation or discharge; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

Sumycin is used for treating infections caused by certain bacteria. Sumycin is a tetracycline antibiotic. It works by slowing the growth of sensitive bacteria by interfering with the production of proteins needed by the bacteria to grow. Slowing the bacteria's growth allows the body's defense mechanisms to destroy them.

Use Sumycin as directed by your doctor.

Take Sumycin by mouth on an empty stomach at least 1 hour before or 2 hours after eating.

Take Sumycin with a full glass of water (8 oz/240 mL). Do not lie down for 30 minutes after taking Sumycin.

If you also take antacids containing aluminum, calcium, or magnesium; preparations containing bismuth, iron, zinc, or sodium bicarbonate; or calcium rich foods (eg, milk, dairy products, calcium-enriched juices), do not take them within 2 to 3 hours before or after taking Sumycin. Check with your doctor if you have questions.

To clear up your infection completely, take Sumycin for the full course of treatment. Keep taking it even if you feel better in a few days.

If you miss a dose of Sumycin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Sumycin.

Store Sumycin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C), in a tightly closed, light-resistant container. Keep away from heat, moisture, and light. Do not store in the bathroom. Keep Sumycin out of the reach of children and away from pets.

Active Ingredient: Tetracycline hydrochloride.

Do NOT use Sumycin if:

you are allergic to any ingredient in Sumycin or other tetracycline antibiotics (eg, doxycycline)

you are taking acitretin or methoxyflurane.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Sumycin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have diarrhea, a stomach infection, or kidney problems.

Some medicines may interact with Sumycin. Tell your health care provider if you are taking any other medicines, especially any of the following:

Acitretin or isotretinoin because side effects, such as increased pressure in the fluid surrounding the brain, may occur

Digoxin, methotrexate, methoxyflurane, or oral anticoagulants (eg, warfarin) because the risk of their side effects may be increased by Sumycin

Atovaquone, lithium, oral contraceptives (birth control pills), or penicillins (eg, amoxicillin) because their effectiveness may be decreased by Sumycin.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Sumycin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Sumycin may cause dizziness or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Sumycin with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Contact your doctor right away if stomach pain or cramps, severe diarrhea, or bloody stools occur. Do not treat diarrhea without first checking with your doctor.

Be sure to use Sumycin for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The bacteria could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.

Sumycin may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Sumycin. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.

Do not use after expiration date. Outdated medicine is highly toxic to the kidneys.

Long-term or repeated use of Sumycin may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.

Hormonal birth control (eg, birth control pills) may not work as well while you are using Sumycin. To prevent pregnancy, use an extra form of birth control (eg, condoms).

Lab tests may be performed while you use Sumycin. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use of Sumycin in children may cause permanent discoloring of the teeth.

Sumycin should be used with extreme caution in children younger 8 years; safety and effectiveness in these children have not been confirmed.

Pregnancy and beast-feeding: Sumycin has been shown to cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Sumycin while you are pregnant. Sumycin is found in breast milk. Do not breast-feed while taking Sumycin.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Black hairy tongue; blurred vision; bulky loose stools; diarrhea; difficulty swallowing; fever; headache; hives; hoarseness; indigestion; inflammation or redness of tongue; joint pain; loss of appetite; mouth sores; nausea; rash; sensitivity to sunlight; sore throat; stomach pain; swelling and itching of the rectum.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); infection (fever, chills, sore throat); itching; nausea; severe skin reaction to the sun; vaginal irritation or discharge; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.



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Common And Rare Side Effects For Robamol-Aspirin Oral, Robamol

Side Effects

List Robamol-Aspirin side effects by likelihood and severity.

The following side effects are associated with Robamol-Aspirin:

Common side effects of Robamol-Aspirin:

Problems with Eyesight Severe

Signs and Symptoms at Injection Site Severe

Blurred Vision Less Severe

Conditions of Excess Stomach Acid Secretion Less Severe

Dizzy Less Severe

Double Vision Less Severe

Feel Like Throwing Up Less Severe

Heartburn Less Severe

Irritation of the Stomach or Intestines Less Severe

Stomach Cramps Less Severe

Throwing Up Less Severe

Infrequent side effects of Robamol-Aspirin:

Fever caused by Administration of a Drug Severe

Pink Eye Severe

Slow Heartbeat Severe

Stuffy Nose Severe

Head Pain Less Severe

Involuntary Eye Movement Less Severe

Muscle Weakness Less Severe

Temporary Redness of Face and Neck Less Severe

Rare side effects of Robamol-Aspirin:

A Rupture in the Wall of the Stomach or Intestine Severe

Abnormally Low Blood Pressure Severe

Anemia Severe

Bleeding of the Stomach or Intestines Severe

Blood Clot in Vein Severe

Blood coming from Anus Severe

Bronchospasm Severe

Confused Severe

Decrease in the Ability of Platelet Cells to Clot Severe

Decreased Blood Platelets Severe

Decreased White Blood Cells Severe

Drowsiness Severe

Dyskinesia Severe

Feeling Faint Severe

Fit Severe

Giant Hives Severe

Hemolytic Anemia Severe

Hemorrhage Within the Skull Severe

Hepatitis caused by Drugs Severe

Hives Severe

Inflammation of Skin caused by an Allergy Severe

Interstitial Nephritis Severe

Itching Severe

Large Purple or Brown Skin Blotches Severe

Life Threatening Allergic Reaction Severe

Ringing in the Ears Severe

Seizures Severe

Small Skin Blister Severe

Stomach or Intestinal Ulcer Severe

Trouble Breathing Severe

Wheezing Severe

Yellowing of Skin or Eyes from Bile Flow Problems Severe

Yellowing of Skin or Eyes from Liver Problems Severe

Abnormal Liver Function Tests Less Severe

Burning Stomach Less Severe

Chronic Trouble Sleeping Less Severe

Collection of Clotted Blood in an Organ, Space or Tissue Less Severe

Indigestion Less Severe

Inducing of a Relaxed Easy State Less Severe

Loss of Appetite Less Severe

Loss of Memory Less Severe

Rash Less Severe

Redness of Skin Less Severe

Sensation of Spinning or Whirling Less Severe

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Super Gels - Scents, Pro-Cure

Super Gels

Super Gel has gotten more effective with the addition of UV enhancement. It's like attaching a lit light bulb to your lure or bait. The visibility brings fish in to investigate, and the scent gets them to feed. There is no other product on the market that even comes close to performing like Super Gel. Made from real bait and enhanced with powerful amino acids in a sticky base that sticks to lures, spoons, spinners, swim baits, soft baits, etc. for an exceptionally long time. Word of mouth has spread like wild fire, and in 26 years of making great products we've never had a product catch on like Super Gel. In both fresh and salt water formulas. Available in 2 oz. squeeze bottles or 8 oz. Guide Size squeeze bottles.

You can NOT inject gels with the bait injectors or the injector heads. The gel is too thick.

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Senexon-S Oral Uses, Side Effects, Interactions, Pictures, Warnings - Dosing, Senexon

Senexon-S

Uses

This product is used to treat constipation. It contains 2 medications. sennosides and docusate. Sennosides are known as stimulant laxatives. They work by keeping water in the intestines. which helps to cause movement of the intestines. Docusate is known as a stool softener. It helps increase the amount of water in the stool, making it softer and easier to pass.

How to use Senexon-S

Take this medication by mouth with a full glass of water (8 ounces/240 milliliters) as directed by your doctor. If you are self-treating, follow all directions on the product package. If you are uncertain about any of the information, ask your doctor or pharmacist.

Dosage is based on your age, medical condition, and response to treatment. Do not increase your dose or take this drug more often than directed. Do not take this medication for more than 7 days unless directed by your doctor. Serious side effects may occur with overuse of this medication (see also Side Effects section).

It may take 6 to 12 hours before this medication causes a bowel movement. Tell your doctor if your condition persists or worsens, or if bleeding from the rectum occurs. If you think you may have a serious medical problem, seek immediate medical attention.

Side Effects

Stomach /abdominal pain or cramping, nausea. diarrhea. or weakness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

This medication may cause your urine to turn reddish-brown. This effect is harmless and will disappear when the medication is stopped.

If your doctor has directed you to use this medication, remember that he or she has judged that the benefit to you is greater than the risk of side effects. Many people who use this medication correctly do not have serious side effects.

Tell your doctor right away if any of these unlikely but serious side effects occur: persistent nausea/vomiting /diarrhea, muscle cramps /weakness, irregular heartbeat. dizziness. decreased urination, mental/mood changes (such as confusion).

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction. including: rash. itching /swelling (especially of the face/tongue /throat), severe dizziness, trouble breathing .

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking this product, tell your doctor or pharmacist if you are allergic to senna, sennosides, or docusate; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: appendicitis or symptoms of appendicitis (such as nausea/vomiting, sudden or unexplained stomach /abdominal pain), a sudden change in bowel habits that lasts for longer than 2 weeks, bleeding from the rectum, intestinal blockage.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Tell your doctor if you are pregnant before using this medication. Using it for long periods during pregnancy is not recommended. Consult your doctor for more details.

This medication passes into breast milk, but is unlikely to harm a nursing infant. Consult your doctor before breast - feeding.

Interactions

The effects of some drugs can change if you take other drugs or herbal products at the same time. This can increase your risk for serious side effects or may cause your medications not to work correctly. These drug interactions are possible, but do not always occur. Your doctor or pharmacist can often prevent or manage interactions by changing how you use your medications or by close monitoring.

To help your doctor and pharmacist give you the best care, be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products) before starting treatment with this product. While using this product, do not start, stop, or change the dosage of any other medicines you are using without your doctor's approval.

A product that may interact with this drug is: mineral oil .

This document does not contain all possible drug interactions. Keep a list of all the products you use. Share this list with your doctor and pharmacist to lessen your risk for serious medication problems.

Overdose

If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: severe stomach/abdominal pain or cramping, persistent nausea/vomiting/diarrhea.

Notes

Keep all regular medical and laboratory appointments.

Lifestyle changes that may prevent or relieve constipation include exercising. drinking enough water, and eating a proper diet with fiber-rich foods such as bran, fresh fruits/vegetables. Talk to your doctor or pharmacist about lifestyle changes that might benefit you.

Missed Dose

If your doctor has directed you to take this medication on a regular schedule and you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Different brands of this medication have different storage needs. Check the product package for instructions on how to store your brand, or ask your pharmacist. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Information last revised October 2015. Copyright(c) 2015 First Databank, Inc.

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Hydrochlorothiazide is used for treating high blood pressure. It is also used to treat fluid buildup in the body caused by certain conditions (eg, heart failure, liver cirrhosis, kidney problems) or medicines (eg, corticosteroids, estrogen). It may be used alone or with other medicines. Hydrochlorothiazide is a thiazide diuretic. It helps the kidneys to remove fluid from the body.

Use Hydrochlorothiazide as directed by your doctor.

Take Hydrochlorothiazide by mouth with or without food.

Hydrochlorothiazide may increase the amount of urine or cause you to urinate more often when you first start taking it. To keep this from disturbing your sleep, try to take your dose before 6 pm.

If you miss a dose of Hydrochlorothiazide, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Hydrochlorothiazide.

Store Hydrochlorothiazide at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Hydrochlorothiazide out of the reach of children and away from pets.

Do NOT use Hydrochlorothiazide if:

you are allergic to any ingredient in Hydrochlorothiazide

you are unable to urinate

you are taking dofetilide or ketanserin.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Hydrochlorothiazide. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have had a severe allergic reaction (eg, rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue) to a sulfonamide medicine (eg, sulfamethoxazole)

if you have gout, liver problems, (eg, cirrhosis), lupus, kidney problems, diabetes, asthma, parathyroid gland problems, or high blood cholesterol or lipid levels

if you have high or low blood electrolyte levels (eg, sodium, potassium, magnesium, calcium)

if you are taking another medicine for high blood pressure.

Some medicines may interact with Hydrochlorothiazide. Tell your health care provider if you are taking any other medicines, especially any of the following:

Digoxin, dofetilide, or ketanserin because the risk of irregular heartbeat may be increased

Barbiturates (eg, phenobarbital), corticotropin, corticosteroids (eg, prednisone), or narcotic pain medicines (eg, codeine) because they may increase the risk of Hydrochlorothiazide's side effects

Cholestyramine, colestipol, or nonsteroidal anti-inflammatory medicines (NSAIDs) (eg, ibuprofen) because they may decrease Hydrochlorothiazide's effectiveness

Diazoxide or lithium because the risk of their side effects may be increased by Hydrochlorothiazide

Diabetes medicines (eg, glipizide, metformin) or insulin because their effectiveness may be decreased by Hydrochlorothiazide.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Hydrochlorothiazide may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

Hydrochlorothiazide may cause dizziness or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Hydrochlorothiazide with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.

Hydrochlorothiazide may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.

Your doctor may also prescribe a potassium supplement for you. If so, take the potassium supplement exactly as prescribed. Do not start taking additional potassium on your own or change your diet to include more potassium without first checking with your doctor.

Tell your doctor or dentist that you take Hydrochlorothiazide before you receive any medical or dental care, emergency care, or surgery.

Tell your doctor if you will be exposed to high temperatures. The risk of certain side effects (eg, low blood sodium levels) may be increased in hot weather.

Hydrochlorothiazide may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Hydrochlorothiazide. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.

Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.

Hydrochlorothiazide may raise your blood sugar. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away.

Diabetes patients - Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

Hydrochlorothiazide may interfere with certain lab tests, including parathyroid function tests. Be sure your doctor and lab personnel know you are taking Hydrochlorothiazide.

Lab tests, including kidney function, blood pressure, and electrolyte levels, may be performed while you use Hydrochlorothiazide. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

Use Hydrochlorothiazide with caution in the elderly; they may be more sensitive to its effects, especially dizziness.

Pregnancy and breast-feeding: Hydrochlorothiazide may cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Hydrochlorothiazide while you are pregnant. Hydrochlorothiazide is found in breast milk. If you are or will be breast-feeding while you use Hydrochlorothiazide, check with your doctor. Discuss any possible risks to your baby.

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Constipation; diarrhea; dizziness; lightheadedness (especially when sitting up or standing); loss of appetite; nausea; temporary blurred vision.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; dark urine; decreased urination; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; increased thirst; joint pain, swelling, warmth, or redness (especially of the big toe joint); mental or mood changes; muscle pain or cramps; numbness or tingling; red, swollen, blistered, or peeling skin; seizures; severe or persistent dizziness; severe or persistent nausea or stomach pain; shortness of breath; unusual bruising or bleeding; unusual drowsiness, restlessness, tiredness, or weakness; unusually dry mouth; vomiting; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.



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Especial antencion con menores de 2 anos

Tenga especial cuidado durante el embarazo .

No usar ELIPRIM con lactantes.

Revise siempre que no sea alergico a ninguno de los componentes de ELIPRIM . podria poner en peligro su salud

Recuerda antes de tomar este medicamento consultar siempre con su medico, la informacion que ofrecemos es orientativa y no sustituye en ningun caso la de su medico u otro profesional de la salud.

Prospecto e indicaciones

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Av. Separadora Industrial 1823 Mz. C2 Lt.4 Urb. El Artesano, Ate-Vitarte Tel: Central: 436-3699 Fax: 436-5480 [email protected] com

COMPOSICIÓN ELIPRIM PEDIÁTRICO SUSPENSIÓN Cada 5 mL contiene: Sulfametoxazol 200,0 mg Trimetoprima 40,0 mg Excipientes c. s. ELIPRIM FORTE SUSPENSIÓN Cada 5 mL contiene: Sulfametoxazol 400,0 mg Trimetoprima 80,0 mg Excipientes c. s.

INDICACIONES

INDICACIONES: ELIPRIM Suspensión está indicado en el tratamiento de las exacerbaciones agudas de bronquitis crónica en adultos; en infecciones bacterianas del tracto urinario; en enterocolitis causada por Shigella flexneri y S. sonnei; en otitis media aguda en niños; en la profilaxis y tratamiento de la neumonía por Pneumo­cystis carinii (considerado el tratamiento de elección) y en el tratamiento de la? diarrea del viajero? causada por Escherichia coli enterotoxi­génico y especies de Shigella. Además puede ser usado en el tratamiento de infecciones biliares, infecciones de huesos y articulaciones; isosporiasis; linfogranuloma venéreo, nocardiasis, sinusitis, paracoccidioidomicosis, e infecciones de la piel y tejido blando causados por organismos susceptibles. Es una alternativa en el tratamiento del chancro, infecciones de clamidia, endocarditis bacteriana, gonorrea, granuloma inguinal, meningitis, septicemia bacteriana, fiebres tifoidea y paratifoidea.

CONTRAINDICACIONES Y ADVERTENCIAS

CONTRAINDICACIONES En hipersensibilidad a las sulfonamidas, furosemida, diuréticos tiazídicos, sulfonilureas o inhibidores de la anhidrasa carbónica, sulfitos o trimetoprima. Evaluar relación riesgo-beneficio en casos de discrasias sanguíneas, fallas de la función hepática y renal, anemia megaloblástica debido a deficiencia de ácido fólico, porfiria y deficiencia de G6PD. Está contraindicado en niños menores de 2 meses de edad, excepto bajo circunstancias especiales.

PRECAUCIONES Y ADVERTENCIAS ESPECIALES

PRECAUCIONES Embarazo: Puede interferir en el metabolismo del ácido fólico en el feto. Su uso no es recomendado al término del embarazo porque puede causar ictericia, anemia hemolítica y kernicterus en neonatos. Lactancia: Ambos principios activos se distribuyen en la leche materna. El sulfametoxazol puede causar kernicterus en lactantes y la trimetoprima puede interferir en el metabolismo de ácido fólico. Geriatría: En pacientes de edad avanzada, especialmente aquellos que toman diuréticos, puede incrementarse el riesgo de aparición de efectos adversos. En caso de tratamientos prolongados visitar regularmente al médico para verificar los recuentos sanguíneos, si los recuentos no son normales tener cuidado al utilizar mondadientes, cepillos o hilos dentales. Evitar la excesiva exposición a la luz o lámparas solares. Consultar con el médico si no se observa mejoría en pocos días. ADVERTENCIAS Agitar bien el frasco antes de usar. Mantener alejado de los niños. Venta con receta médica. Puede causar mareos.

EFECTOS ADVERSOS

REACCIONES ADVERSAS Puede presentarse ciertas reacciones como hipersensibilidad, fotosensibilidad, discrasias sanguíneas, hepatitis colestática, pancreatitis, síndrome de Stevens? Johnson, necrólisis epidérmica tóxica, meningitis aséptica, toxicidad del SNC, colitis por Clostridium difficile, cristaluria, hematuria, disturbios de la función tiroidea, bocio, nefritis intersticial o necrosis tubular, metahemoglobinemia, rabdomio­lisis y tromboflebitis. En pacientes de edad avanzada que estén ingiriendo diuréticos concurrente­mente pueden presentarse problemas de la piel y sanguíneos.

INTERACCIONES MEDICAMENTOSAS

INTERACCIONES El uso concomitante con anticoagulantes derivados de la cumarina, indandiona, anticonvulsivantes como la hidantoína, agentes antidiabéticos orales, agentes hemolíticos y medicamentos hepatotóxicos puede incrementar o prolongar los efectos y/o toxicidad de los mismos. Con metenamina puede incrementarse el riesgo de cristaluria, con metrotrexato incrementarse la potencia de éste último, con fenilbutazona y sulfin­pirazona incrementar la concentración del sulfa­metoxazol, con depresores de la médula ósea incrementar los efectos leucopénicos o trombocito­pénicos, con contraceptivos orales que contienen estrógenos incrementar la incidencia del sangrado y embarazo a largo plazo, con ciclosporina disminuir la concentración plasmática de esta última, causar rechazo a un potencial transplante o causar nefrotoxicicidad, con penicilinas interferir el efecto bactericida de éstas en el tratamiento de la meningitis o en otras infecciones. Con antagonistas del folato como metotrexato o pirimetamina puede incrementarse el riesgo de anemia megalo­blástica, con dapsona incrementar la concentración plasmática de ambos medicamentos, con fenitoína inhibirse el metabolismo hepático de ésta, con procainamida incrementar la concentración plasmática de ella y de su metabolito, con rifam­picina incrementar la eliminación de la trimeto­prima, y con warfarina potenciar la actividad anticoagulante de ésta. Durante el uso del medicamento pueden darse falsos-positivos en los resultados de glucosa en orina con la prueba de Benedict o de proteínas en orina con la prueba del ácido sulfosalicílico, pueden aumentar los valores de creatinina en la prueba de Jaffé con picrato alcalino, interferir con los resultados de uribilinógeno en orina o de alanina aminotransferasa, aspartato aminotransferasa, bilirrubina, BUN y creatinina en el suero.

Como tomar Y POSOLOGIA

DOSIS Y VÍA DE ADMINISTRACIÓN Oral, la medicación debe tomarse preferiblemente con un vaso lleno de agua con el estómago vacío (una hora antes o después de las comidas). No está recomendado en niños menores a los dos meses de edad, pues puede causarles kernicterus. ELIPRIM PEDIÁTRICO Suspensión ELIPRIM FORTE Suspensión 1. Adultos y adolescentes: 1.1. Antibacteriano: Administrar 800 mg de SMX y 160 mg de TMP cada 12 horas. 4 cucharaditas cada 12 horas. 2 cucharaditas cada 12 horas. 1.2. Antiprotozoario, en neumonía por Pneumocystis carinii: - Tratamiento: Cada 6 horas por 14 a 21 días administrar 18,75 a 25 mg de SMX y 3,75 a 5 mg de TMP por cada kg de peso corporal. - Profilaxis: Administrar 800 mg de SMX y 160 mg de TMP una vez al día. 4 cucharaditas una vez al día. 2 cucharaditas una vez al día. 2. Niños: 2.1. Antibacteriano: - Niños de hasta 40 kg de peso: Cada 12 horas administrar 20 a 30 mg de SMX y 4 a 6 mg de TMP por kg de peso corporal 2 a 5 meses: ? a 1 cucharadita. 6 meses a 5 años: 1 a 2 cucharadita. 6 a 12 años: 2 ? a 4 cucharaditas. 2 a 5 meses: 1/3 a ? cucharadita. 6 meses a 5 años: ? a 1 cucharadita. 6 a 12 años: 1 a 2 cucharaditas. - Niños de más de 40 kg de peso corporal: Administrar 800 mg de SMX y 160 mg de TMP cada 12 horas. 4 cucharaditas cada 12 horas. 2 cucharaditas cada 12 horas. 2.2. Antiprotozoario, en neumonía por Pneumocystis carinii: - Tratamiento: - Profilaxis: En niños de 4 semanas a más: Cada 6 horas por 14 a 21 días administrar 18,75 a 25 mg de SMX y 3,75 a 5 mg de TMP por cada kg de peso corporal. Administrar dos veces al día 375 mg de SMX y 75 mg de TMP por metro cuadrado de superficie corporal, tres veces por semana en días consecutivos.

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Thyrox

Warnings

This medication should not be used for weight loss. Normal doses of this medication will not work for weight loss, and large doses of this medication may cause serious, possibly fatal side effects, especially when taken with diet pills .

Uses

Levothyroxine is used to treat an underactive thyroid (hypothyroidism ). It replaces or provides more thyroid hormone, which is normally produced by the thyroid gland. Low thyroid hormone levels can occur naturally or when the thyroid gland is injured by radiation /medications or removed by surgery. Having enough thyroid hormone is important for maintaining normal mental and physical activity. In children, having enough thyroid hormone is important for normal mental and physical development.

This medication is also used to treat other types of thyroid disorders (such as certain types of goiters, thyroid cancer ).

This medication should not be used to treat infertility unless it is caused by low thyroid hormone levels.

How to use Thyrox

Take this medication by mouth as directed by your doctor, usually once daily on an empty stomach. 30 minutes to 1 hour before breakfast. Take this medication with a full glass of water unless your doctor directs you otherwise.

If you are taking the capsule form of this medication, swallow it whole. Do not split, crush, or chew. People who cannot swallow the capsule whole (such as infants or small children) should use the tablet form of the medication.

For infants or children who cannot swallow whole tablets, crush the tablet and mix in 1 to 2 teaspoons (5 to 10 milliliters) of water, and give using a spoon or dropper right away. Do not prepare a supply in advance or mix the tablet in soy infant formula. Consult your pharmacist for more information.

Dosage is based on your age, weight. medical condition, laboratory test results, and response to treatment.

Use this medication regularly in order to get the most benefit from it. To help you remember, take it at the same time each day.

Do not stop taking this medication without first consulting with your doctor. Thyroid replacement treatment is usually taken for life.

There are different brands of levothyroxine available. Do not change brands without first consulting your doctor or pharmacist.

Certain medications (such as cholestyramine. colestipol. colesevelam. antacids, sucralfate, simethicone. iron, sodium polystyrene sulfonate, calcium supplements. orlistat. sevelamer. among others) can decrease the amount of thyroid hormone that is absorbed by your body. If you are taking any of these drugs, separate them from this medication by at least 4 hours.

Symptoms of low thyroid hormone levels include tiredness, muscle aches, constipation. dry skin. weight gain, slow heartbeat, or sensitivity to cold. Tell your doctor if your condition worsens or persists after several weeks of taking this medication.

Side Effects

Hair loss may occur during the first few months of treatment. This effect is usually temporary as your body adjusts to this medication. If this effect persists or worsens, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if any of these unlikely but serious effects of high thyroid hormone levels occur: increased sweating. sensitivity to heat, mental/mood changes (such as nervousness, mood swings), tiredness, diarrhea. shaking (tremor), headache. shortness of breath.

Get medical help right away if any of these rare but serious effects of high thyroid hormone levels occur: chest pain. fast/pounding/irregular heartbeat. swelling hands/ankles /feet, seizures .

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction. including: rash. itching /swelling (especially of the face/tongue /throat), severe dizziness. trouble breathing .

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www. fda. gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking levothyroxine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: increased thyroid hormones (thyrotoxicosis), decreased adrenal gland function, heart disease (such as coronary artery disease, irregular heartbeat), high blood pressure, diabetes.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Current information shows that this drug may be used during pregnancy. Tell your doctor if you are pregnant because your dose may need to be adjusted.

Levothyroxine passes into breast milk but is unlikely to harm a nursing infant. Consult your doctor before breast-feeding.

Interactions

See also How to Use Section.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: "blood thinners" (such as warfarin), digoxin, sucroferric oxyhydroxide, theophylline.

Overdose

If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: fast/pounding/irregular heartbeat, loss of consciousness, confusion, seizures.

Notes

Do not share this medication with others.

Laboratory and/or medical tests (such as thyroid function tests) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up unless your doctor tells you to do so. Call your doctor if you miss 2 or more doses in a row. Ask your doctor ahead of time what to do about a missed dose and follow your doctor's specific directions.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Information last revised October 2015. Copyright(c) 2015 First Databank, Inc.

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No data available at this time.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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222 AF; 4'-Hydroxyacetanilide; 4-(Acetylamino)phenol; 4-Acetamidophenol; 4-Hydroxyanilid kyseliny octove [Czech]; A-Per; A. F. Anacin; APAP; Abenol; Abensanil; Abrol; Abrolet; Acamol; Acenol; Acenol (pharmaceutical); Acephen; Acertol; Acetaco; Acetagesic; Acetalgin; Acetamide, N-(p-hydroxyphenyl)-; Acetaminofen; Acetamol; Acetanilide, 4'-hydroxy-; Acetofen; Actron; Afebrin; Afebryl; Aferadol; Algesidal; Algina; Algomol; Algotropyl; Alpiny; Alvedon; Amadil; Anacin-3; Anadin dla dzieci; Anaflon; Analter; Andox; Anelix; Anhiba; Anti-Algos; Antidol; Apacet; Apamide; Apitrelal; Arfen; Asetam; Asomal; Aspac; Asplin; Atasol; Atralidon; Babikan; Bacetamol; Banesin; Ben-u-ron; Benmyo; Biocetamol; Cadafen; Calapol; Calmanticold; Calpol; Capital with Codeine; Captin; Causalon; Cefalex; Children's Acetaminophen Elixir Drops; Children's Acetaminophen Elixir Solution; Children's Acetaminophen Oral Solution; Children's Tylenol Chewable; Claradol Codeine; Clixodyne; Cod-Acamol Forte; Codabrol; Codalgin; Codapane; Codicet; Codisal; Codisal Forte; Codoliprane; Codral Pain Relief; Cofamol; Contra-Schmerz P; Cosutone; Crocin; Croix Blanche; Cuponol; Curadon; Curpol; Custodial; Dafalgan; Dafalgan Codeine; Darocet; Datril; Daygrip; Deminofen; Democyl; Demogripal; Desfebre; Dhamol; Dial-a-gesic; Dirox; Disprol; Dol-Stop; Dolcor; Dolefin; Dolegrippin; Dolgesic; Doliprane; Dolko; Dolofugin; Doloreduct; Dolorfug; Dolorol Forte; Dolorstop; Dolotec; Dolprone; Dorocoff; Dresan; Dristancito; Duaneo; Duorol; Duracetamol; Durapan; Dymadon; Dymadon Co; Dymadon Forte; Ecosetol; Enelfa; Eneril; Eu-Med; Excipain; Exdol; Fanalgic; Farmadol; Febranine; Febrectal; Febrectol; Febrex; Febricet; Febridol; Febrilix; Febrin; Febro-gesic; Febrolin; Fendon; Fensum; Fepanil; Fever All; Finimal; Finiweh; Fluparmol; Fortalidon P; Freka-cetamol; Gattaphen T; Gelocatil; Geluprane; Geralgine-P; Gripin Bebe; Grippostad; Gynospasmine; Hedex; Helon N; Homoolan; Ildamol; Inalgex; Infadrops; Infants' Feverall; Influbene N; Injectapap; Junior Disprol; Kataprin; Kinder Finimal; Kratofin simplex; Labamol; Lekadol; Lemgrip; Lemsip; Lestemp; Liquagesic; Liquigesic Co; Lonarid; Lonarid Mono; Lupocet; Lyteca; Magnidol; Malex N; Malgis; Malidens; Maxadol; Medinol Paediatric; Medocodene; Melabon Infantil; Mexalen; Migraleve Yellow; Minafen; Minoset; Miralgin; Momentum; Mono Praecimed; Multin; N-(4-Hydroxyphenyl)acetamide; N-Acetyl-p-aminophenol; Naprinol; Nebs; Neo-Fepramol; NeoCitran; Neodol; Neodolito; Neopap; Neuridon; New Cortal for Children; NilnOcen; Nina; No-Febril; Nodolex; Noral; Ofirmev; Oltyl; Oralgan; Ortensan; Oxycocet; PCM Paracetamol Lichtenstein; Paceco; Pacemo; Pacemol; Pacet; Pacimol; Paedialgon; Paedol; Paldesic; Pamol; Panacete; Panadeine; Panadeine Co; Panadiene; Panado-Co; Panado-Co Caplets; Panadol; Panamax; Panasorbe; Panets; Panodil; Pantalgin; Para-Suppo; Para-Tabs; Paracemol; Paracenol; Paracet; Paracetamol; Paracetamol AL; Paracetamol Antipanin P; Paracetamol BC; Paracetamol Basics; Paracetamol Dr. Schmidgall; Paracetamol Fecofar; Paracetamol Genericon; Paracetamol Hanseler; Paracetamol Harkley; Paracetamol Heumann; Paracetamol Hexal; Paracetamol Italfarmaco; Paracetamol Nycomed; Paracetamol PB; Paracetamol Raffo; Paracetamol Ratiopharm; Paracetamol Rosch; Paracetamol Saar; Paracetamol SmithKline Beecham; Paracetamol Stada; Paracetamol Winthrop; Paracetamol von ct; Paracetamolo [Italian]; Paracetamolum [INN-Latin]; Paracetol; Paracin; Paracod; Paracodol; Parador; Paradrops; Parakapton; Parake; Paralen; Paralief; Paralink; Paralyoc; Paramol; Paramolan; Paranox; Parasedol; Parasin; Parcetol; Parmol; Parogal; Paroma; Pe-Tam; Pediapirin; Pediatrix; Percocet-5; Percocet-Demi; Perdolan Mono; Perfalgan; Phenaphen; Phenaphen W/Codeine; Phenipirin; Phogoglandin; Pinex; Piramin; Pirinasol; Plicet; Polmofen; Predimol; Predualito; Prodol; Prontina; Puernol; Pulmofen; Pyregesic-C; Pyrigesic; Pyrinazine; Pyromed; Reliv; Remedol; Rockamol Plus; Rounox; RubieMol; Rubophen; Rupemol; Salzone; Sanicet; Sanicopyrine; Scanol; Scentalgyl; Scherzatabletten Rezeptur 534; Schmerzex; Sedalito; Semolacin; Servigesic; Seskamol; Setakop; Setamol; Setol; Sifenol; Sinaspril; Sinedol; Sinmol; Spalt N; Spalt fur die nacht; St Joseph Aspirin-Free; St Joseph Aspirin-Free for Children; Stanback; Stopain; Sunetheton; Supadol mono; Supofen; Suppap; Supramol-M; Tabalgin; Tachiprina; Tapar; Tazamol; Tempra; Termacet; Termalgin; Termalgine; Termofren; Tiffy; Titralgan; Toximer P; Tralgon; Treupel N; Treupel mon; Treuphadol; Tricoton; Tussapap; Tylenol; Tylenol (caplet); Tylenol (geltab); Tylenol 8-Hour; Tylex; Tylex CD; Tylol; Tymol; Upsanol; Utragin; Valadol; Valgesic; Veralgina; Vermidon; Verpol; Viclor Richet; Vips; Viruflu; Vivimed; Volpan; Zatinol; Zolben; p-Acetamidophenol; p-Acetaminophenol; p-Acetylaminophenol; p-Hydroxyacetanilide; Acetamide, N-(4-hydroxyphenyl)-; [ChemIDplus]

Colorless solid; [ICSC] Odorless white solid; [CAMEO] White powder; [Sigma-Aldrich MSDS]

Registered for use in the US for control of brown tree snakes; [NPIRS] Used to make azo dyes, photographic chemicals, and pharmaceuticals, as a stabilizer for hydrogen peroxide, and as a therapeutic analgesic and antipyretic; [HSDB]

Ingestion may cause injury to the liver and kidneys; [ICSC] Histopathological changes of the liver, kidney, reproductive organs, thymus, and lymph nodes observed in 13-week feeding study of rats at 25,000 ppm; No evidence of carcinogenicity in male rats, male mice, or female mice; Equivocal evidence in female rats; [NTP] High oral doses produce testicular toxicity in rats and impaired spermiogenesis and testicular atrophy in mice and rats; [REPROTOX] A skin and strong eye irritant; Harmful by ingestion; Targets the liver and kidney; [Sigma-Aldrich MSDS]

Major Category

Synonyms

222 AF; 4'-Hydroxyacetanilide; 4-(Acetylamino)phenol; 4-Acetamidophenol; 4-Hydroxyanilid kyseliny octove [Czech]; A-Per; A. F. Anacin; APAP; Abenol; Abensanil; Abrol; Abrolet; Acamol; Acenol; Acenol (pharmaceutical); Acephen; Acertol; Acetaco; Acetagesic; Acetalgin; Acetamide, N-(p-hydroxyphenyl)-; Acetaminofen; Acetamol; Acetanilide, 4'-hydroxy-; Acetofen; Actron; Afebrin; Afebryl; Aferadol; Algesidal; Algina; Algomol; Algotropyl; Alpiny; Alvedon; Amadil; Anacin-3; Anadin dla dzieci; Anaflon; Analter; Andox; Anelix; Anhiba; Anti-Algos; Antidol; Apacet; Apamide; Apitrelal; Arfen; Asetam; Asomal; Aspac; Asplin; Atasol; Atralidon; Babikan; Bacetamol; Banesin; Ben-u-ron; Benmyo; Biocetamol; Cadafen; Calapol; Calmanticold; Calpol; Capital with Codeine; Captin; Causalon; Cefalex; Children's Acetaminophen Elixir Drops; Children's Acetaminophen Elixir Solution; Children's Acetaminophen Oral Solution; Children's Tylenol Chewable; Claradol Codeine; Clixodyne; Cod-Acamol Forte; Codabrol; Codalgin; Codapane; Codicet; Codisal; Codisal Forte; Codoliprane; Codral Pain Relief; Cofamol; Contra-Schmerz P; Cosutone; Crocin; Croix Blanche; Cuponol; Curadon; Curpol; Custodial; Dafalgan; Dafalgan Codeine; Darocet; Datril; Daygrip; Deminofen; Democyl; Demogripal; Desfebre; Dhamol; Dial-a-gesic; Dirox; Disprol; Dol-Stop; Dolcor; Dolefin; Dolegrippin; Dolgesic; Doliprane; Dolko; Dolofugin; Doloreduct; Dolorfug; Dolorol Forte; Dolorstop; Dolotec; Dolprone; Dorocoff; Dresan; Dristancito; Duaneo; Duorol; Duracetamol; Durapan; Dymadon; Dymadon Co; Dymadon Forte; Ecosetol; Enelfa; Eneril; Eu-Med; Excipain; Exdol; Fanalgic; Farmadol; Febranine; Febrectal; Febrectol; Febrex; Febricet; Febridol; Febrilix; Febrin; Febro-gesic; Febrolin; Fendon; Fensum; Fepanil; Fever All; Finimal; Finiweh; Fluparmol; Fortalidon P; Freka-cetamol; Gattaphen T; Gelocatil; Geluprane; Geralgine-P; Gripin Bebe; Grippostad; Gynospasmine; Hedex; Helon N; Homoolan; Ildamol; Inalgex; Infadrops; Infants' Feverall; Influbene N; Injectapap; Junior Disprol; Kataprin; Kinder Finimal; Kratofin simplex; Labamol; Lekadol; Lemgrip; Lemsip; Lestemp; Liquagesic; Liquigesic Co; Lonarid; Lonarid Mono; Lupocet; Lyteca; Magnidol; Malex N; Malgis; Malidens; Maxadol; Medinol Paediatric; Medocodene; Melabon Infantil; Mexalen; Migraleve Yellow; Minafen; Minoset; Miralgin; Momentum; Mono Praecimed; Multin; N-(4-Hydroxyphenyl)acetamide; N-Acetyl-p-aminophenol; Naprinol; Nebs; Neo-Fepramol; NeoCitran; Neodol; Neodolito; Neopap; Neuridon; New Cortal for Children; NilnOcen; Nina; No-Febril; Nodolex; Noral; Ofirmev; Oltyl; Oralgan; Ortensan; Oxycocet; PCM Paracetamol Lichtenstein; Paceco; Pacemo; Pacemol; Pacet; Pacimol; Paedialgon; Paedol; Paldesic; Pamol; Panacete; Panadeine; Panadeine Co; Panadiene; Panado-Co; Panado-Co Caplets; Panadol; Panamax; Panasorbe; Panets; Panodil; Pantalgin; Para-Suppo; Para-Tabs; Paracemol; Paracenol; Paracet; Paracetamol; Paracetamol AL; Paracetamol Antipanin P; Paracetamol BC; Paracetamol Basics; Paracetamol Dr. Schmidgall; Paracetamol Fecofar; Paracetamol Genericon; Paracetamol Hanseler; Paracetamol Harkley; Paracetamol Heumann; Paracetamol Hexal; Paracetamol Italfarmaco; Paracetamol Nycomed; Paracetamol PB; Paracetamol Raffo; Paracetamol Ratiopharm; Paracetamol Rosch; Paracetamol Saar; Paracetamol SmithKline Beecham; Paracetamol Stada; Paracetamol Winthrop; Paracetamol von ct; Paracetamolo [Italian]; Paracetamolum [INN-Latin]; Paracetol; Paracin; Paracod; Paracodol; Parador; Paradrops; Parakapton; Parake; Paralen; Paralief; Paralink; Paralyoc; Paramol; Paramolan; Paranox; Parasedol; Parasin; Parcetol; Parmol; Parogal; Paroma; Pe-Tam; Pediapirin; Pediatrix; Percocet-5; Percocet-Demi; Perdolan Mono; Perfalgan; Phenaphen; Phenaphen W/Codeine; Phenipirin; Phogoglandin; Pinex; Piramin; Pirinasol; Plicet; Polmofen; Predimol; Predualito; Prodol; Prontina; Puernol; Pulmofen; Pyregesic-C; Pyrigesic; Pyrinazine; Pyromed; Reliv; Remedol; Rockamol Plus; Rounox; RubieMol; Rubophen; Rupemol; Salzone; Sanicet; Sanicopyrine; Scanol; Scentalgyl; Scherzatabletten Rezeptur 534; Schmerzex; Sedalito; Semolacin; Servigesic; Seskamol; Setakop; Setamol; Setol; Sifenol; Sinaspril; Sinedol; Sinmol; Spalt N; Spalt fur die nacht; St Joseph Aspirin-Free; St Joseph Aspirin-Free for Children; Stanback; Stopain; Sunetheton; Supadol mono; Supofen; Suppap; Supramol-M; Tabalgin; Tachiprina; Tapar; Tazamol; Tempra; Termacet; Termalgin; Termalgine; Termofren; Tiffy; Titralgan; Toximer P; Tralgon; Treupel N; Treupel mon; Treuphadol; Tricoton; Tussapap; Tylenol; Tylenol (caplet); Tylenol (geltab); Tylenol 8-Hour; Tylex; Tylex CD; Tylol; Tymol; Upsanol; Utragin; Valadol; Valgesic; Veralgina; Vermidon; Verpol; Viclor Richet; Vips; Viruflu; Vivimed; Volpan; Zatinol; Zolben; p-Acetamidophenol; p-Acetaminophenol; p-Acetylaminophenol; p-Hydroxyacetanilide; Acetamide, N-(4-hydroxyphenyl)-; [ChemIDplus]

Category

Description

Colorless solid; [ICSC] Odorless white solid; [CAMEO] White powder; [Sigma-Aldrich MSDS]

Sources/Uses

Registered for use in the US for control of brown tree snakes; [NPIRS] Used to make azo dyes, photographic chemicals, and pharmaceuticals, as a stabilizer for hydrogen peroxide, and as a therapeutic analgesic and antipyretic; [HSDB]

Comments

Ingestion may cause injury to the liver and kidneys; [ICSC] Histopathological changes of the liver, kidney, reproductive organs, thymus, and lymph nodes observed in 13-week feeding study of rats at 25,000 ppm; No evidence of carcinogenicity in male rats, male mice, or female mice; Equivocal evidence in female rats; [NTP] High oral doses produce testicular toxicity in rats and impaired spermiogenesis and testicular atrophy in mice and rats; [REPROTOX] A skin and strong eye irritant; Harmful by ingestion; Targets the liver and kidney; [Sigma-Aldrich MSDS]

Exposure Assessment

Vapor Pressure



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